HOXD12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060529.78652434
2branching involved in prostate gland morphogenesis (GO:0060442)9.22713944
3proximal/distal pattern formation (GO:0009954)7.35454426
4embryonic skeletal joint morphogenesis (GO:0060272)7.33872355
5regulation of mesenchymal cell apoptotic process (GO:2001053)6.93684258
6forelimb morphogenesis (GO:0035136)6.67097992
7male genitalia development (GO:0030539)6.66891588
8embryonic forelimb morphogenesis (GO:0035115)6.57725121
9branch elongation of an epithelium (GO:0060602)5.95939054
10morphogenesis of an epithelial fold (GO:0060571)5.78430643
11axis elongation (GO:0003401)5.70397367
12organ induction (GO:0001759)5.62710433
13mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.46702008
14prostate gland epithelium morphogenesis (GO:0060740)5.23909809
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.22144895
16mesenchymal cell proliferation (GO:0010463)5.18948948
17reproductive system development (GO:0061458)5.16058286
18outer ear morphogenesis (GO:0042473)5.12422548
19positive regulation of chondrocyte differentiation (GO:0032332)5.12400371
20lateral sprouting from an epithelium (GO:0060601)5.04977042
21positive regulation of cartilage development (GO:0061036)4.92982327
22paraxial mesoderm development (GO:0048339)4.90367472
23limb morphogenesis (GO:0035108)4.84804264
24appendage morphogenesis (GO:0035107)4.84804264
25* embryonic digit morphogenesis (GO:0042733)4.77173207
26embryonic limb morphogenesis (GO:0030326)4.75600710
27embryonic appendage morphogenesis (GO:0035113)4.75600710
28hindlimb morphogenesis (GO:0035137)4.70266972
29midgut development (GO:0007494)4.66040108
30regulation of organ formation (GO:0003156)4.63649988
31cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.57206762
32planar cell polarity pathway involved in neural tube closure (GO:0090179)4.42595843
33cranial suture morphogenesis (GO:0060363)4.17398884
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.14684403
35negative regulation of DNA repair (GO:0045738)4.12425068
36middle ear morphogenesis (GO:0042474)4.07014385
37body morphogenesis (GO:0010171)4.00265852
38uterus development (GO:0060065)3.98516470
39embryonic cranial skeleton morphogenesis (GO:0048701)3.92884251
40regulation of heart morphogenesis (GO:2000826)3.92197952
41embryonic hindlimb morphogenesis (GO:0035116)3.89816964
42endothelial cell morphogenesis (GO:0001886)3.85995704
43cell migration involved in heart development (GO:0060973)3.85836624
44regulation of chondrocyte differentiation (GO:0032330)3.85274156
45genitalia development (GO:0048806)3.85271511
46positive regulation of transcription regulatory region DNA binding (GO:2000679)3.81393479
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76188607
48metanephros development (GO:0001656)3.70849206
49regulation of cartilage development (GO:0061035)3.70812940
50epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.67184680
51cell proliferation involved in metanephros development (GO:0072203)3.62615504
52embryonic skeletal system morphogenesis (GO:0048704)3.57422621
53craniofacial suture morphogenesis (GO:0097094)3.56138895
54cochlea morphogenesis (GO:0090103)3.53430095
55regulation of transforming growth factor beta2 production (GO:0032909)3.53385493
56glucocorticoid receptor signaling pathway (GO:0042921)3.49355855
57negative regulation of axon extension involved in axon guidance (GO:0048843)3.49198122
58developmental induction (GO:0031128)3.46960601
59bone trabecula formation (GO:0060346)3.41449377
60branching involved in ureteric bud morphogenesis (GO:0001658)3.40720034
61mesenchymal to epithelial transition (GO:0060231)3.38152136
62cell-cell signaling involved in cell fate commitment (GO:0045168)3.33107003
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31879032
64lung-associated mesenchyme development (GO:0060484)3.31018098
65hippo signaling (GO:0035329)3.30468160
66regulation of secondary heart field cardioblast proliferation (GO:0003266)3.30069834
67regulation of cardioblast proliferation (GO:0003264)3.30069834
68negative regulation of chondrocyte differentiation (GO:0032331)3.23768562
69negative regulation of RNA splicing (GO:0033119)3.23192558
70regulation of morphogenesis of a branching structure (GO:0060688)3.22681011
71establishment of planar polarity (GO:0001736)3.21601611
72establishment of tissue polarity (GO:0007164)3.21601611
73metanephric mesenchyme development (GO:0072075)3.20874874
74regulation of establishment of planar polarity (GO:0090175)3.19703235
75notochord development (GO:0030903)3.18828331
76negative regulation of mRNA processing (GO:0050686)3.18037251
77cartilage morphogenesis (GO:0060536)3.15882607
78non-canonical Wnt signaling pathway (GO:0035567)3.14812754
79eyelid development in camera-type eye (GO:0061029)3.14526919
80positive regulation of mesenchymal cell proliferation (GO:0002053)3.13971812
81cell surface receptor signaling pathway involved in heart development (GO:0061311)3.13133207
82neuron projection extension involved in neuron projection guidance (GO:1902284)3.12540777
83axon extension involved in axon guidance (GO:0048846)3.12540777
84G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.10669664
85polarized epithelial cell differentiation (GO:0030859)3.05962414
86mesenchyme morphogenesis (GO:0072132)3.05811607
87positive regulation of smoothened signaling pathway (GO:0045880)3.01585004
88negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.98853368
89endocardial cushion development (GO:0003197)2.97902650
90kidney mesenchyme development (GO:0072074)2.96314202
91skeletal system morphogenesis (GO:0048705)2.96256375
92chondrocyte proliferation (GO:0035988)2.93565674
93mesenchyme development (GO:0060485)2.91466889
94regulation of mesenchymal cell proliferation (GO:0010464)2.88548280
95DNA unwinding involved in DNA replication (GO:0006268)2.87805095
96regulation of sister chromatid cohesion (GO:0007063)2.86839102
97mesenchymal-epithelial cell signaling (GO:0060638)2.83450697
98negative regulation of epidermis development (GO:0045683)2.81123628
99positive regulation of hormone biosynthetic process (GO:0046886)2.80971508
100regulation of branching involved in prostate gland morphogenesis (GO:0060687)10.7589707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.10358092
2TP63_19390658_ChIP-ChIP_HaCaT_Human5.06473868
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.36578852
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.29435604
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.83182829
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.44987855
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.21950806
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.86346645
9PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.83701839
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.81553833
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.72704067
12* TP53_20018659_ChIP-ChIP_R1E_Mouse2.64252850
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.60784818
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53795885
15* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53525675
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50360007
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.47313951
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.41673461
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.38538229
20* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.30352391
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29651376
22ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27688281
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20561798
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18199215
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.14136876
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.12019223
27* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09352952
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09352952
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98332548
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95633543
31* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.95287547
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.91060099
33AR_21909140_ChIP-Seq_LNCAP_Human1.84879405
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82228145
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.81440759
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81359421
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79375726
38* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79041835
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.78861503
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.77450450
41* RING1B_27294783_Chip-Seq_NPCs_Mouse1.76679214
42* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73510133
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.69065506
44* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67201110
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65802791
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61501946
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.60067489
48MYC_22102868_ChIP-Seq_BL_Human1.56338743
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55504810
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.49185603
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47028915
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46207611
53* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45410162
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.44513068
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43331255
56* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38770524
57CLOCK_20551151_ChIP-Seq_293T_Human1.36768574
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36651270
59STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.35462548
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32902084
61* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30876025
62XRN2_22483619_ChIP-Seq_HELA_Human1.29663245
63* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29468790
64* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29393651
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28817875
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28334993
67* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22459770
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.22189343
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.22170026
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.18693953
71CHD1_26751641_Chip-Seq_LNCaP_Human1.09591366
72* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03513656
73* KDM2B_26808549_Chip-Seq_JURKAT_Human1.02254325
74CIITA_25753668_ChIP-Seq_RAJI_Human1.01762686
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01469520
76VDR_21846776_ChIP-Seq_THP-1_Human1.01463125
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99855234
78ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99780423
79TRIM28_21343339_ChIP-Seq_HEK293_Human0.95928371
80* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95785560
81* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95733838
82NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95697362
83* EZH2_27294783_Chip-Seq_ESCs_Mouse0.95188573
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94796820
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93939314
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93667855
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93059983
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93059983
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93059983
90* KDM2B_26808549_Chip-Seq_DND41_Human0.92943736
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92076685
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91731356
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91682630
94TTF2_22483619_ChIP-Seq_HELA_Human0.90076237
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87270098
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87083730
97CREB1_26743006_Chip-Seq_LNCaP_Human0.86242804
98* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85414671
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85117328
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84964320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0009053_abnormal_anal_canal6.78360213
2MP0005187_abnormal_penis_morphology5.54147145
3MP0000537_abnormal_urethra_morphology5.29580543
4MP0010030_abnormal_orbit_morphology3.70667008
5MP0003123_paternal_imprinting3.66753300
6MP0003937_abnormal_limbs/digits/tail_de3.53568442
7MP0003315_abnormal_perineum_morphology3.51376773
8MP0003385_abnormal_body_wall3.24434085
9MP0009250_abnormal_appendicular_skeleto3.14372938
10MP0003122_maternal_imprinting2.93519450
11MP0005503_abnormal_tendon_morphology2.85413719
12MP0003942_abnormal_urinary_system2.85158290
13MP0002932_abnormal_joint_morphology2.61716712
14MP0005367_renal/urinary_system_phenotyp2.37929611
15MP0000516_abnormal_urinary_system2.37929611
16MP0000049_abnormal_middle_ear2.09799640
17MP0002282_abnormal_trachea_morphology2.06235407
18MP0003941_abnormal_skin_development1.95113178
19MP0000534_abnormal_ureter_morphology1.94476607
20MP0000428_abnormal_craniofacial_morphol1.93897466
21MP0003121_genomic_imprinting1.93127920
22MP0000566_synostosis1.90534767
23MP0002249_abnormal_larynx_morphology1.88232794
24* MP0002109_abnormal_limb_morphology1.82122062
25* MP0002115_abnormal_skeleton_extremities1.81871799
26MP0003567_abnormal_fetal_cardiomyocyte1.74343390
27MP0003705_abnormal_hypodermis_morpholog1.71646797
28MP0005248_abnormal_Harderian_gland1.64939633
29MP0002938_white_spotting1.59775185
30MP0006054_spinal_hemorrhage1.59140343
31MP0001849_ear_inflammation1.55909464
32MP0005508_abnormal_skeleton_morphology1.54362803
33MP0003755_abnormal_palate_morphology1.53100076
34MP0003115_abnormal_respiratory_system1.50048636
35MP0000733_abnormal_muscle_development1.45625481
36MP0003938_abnormal_ear_development1.40474297
37* MP0002114_abnormal_axial_skeleton1.39174742
38MP0003935_abnormal_craniofacial_develop1.38318589
39MP0000767_abnormal_smooth_muscle1.37325350
40MP0002233_abnormal_nose_morphology1.27962597
41MP0003119_abnormal_digestive_system1.23823604
42MP0002116_abnormal_craniofacial_bone1.22966349
43* MP0002085_abnormal_embryonic_tissue1.18918541
44MP0008438_abnormal_cutaneous_collagen1.17448828
45MP0002113_abnormal_skeleton_development1.14960808
46MP0000163_abnormal_cartilage_morphology1.14297704
47MP0000647_abnormal_sebaceous_gland1.12463786
48MP0002177_abnormal_outer_ear1.10395859
49MP0002111_abnormal_tail_morphology1.10069290
50MP0005623_abnormal_meninges_morphology1.07265327
51MP0001299_abnormal_eye_distance/1.06156983
52MP0002084_abnormal_developmental_patter1.04776544
53MP0004197_abnormal_fetal_growth/weight/1.04228489
54MP0004233_abnormal_muscle_weight1.03882896
55MP0000432_abnormal_head_morphology1.03505686
56MP0000762_abnormal_tongue_morphology1.03076012
57MP0009672_abnormal_birth_weight1.01120914
58MP0001293_anophthalmia0.98806985
59* MP0001672_abnormal_embryogenesis/_devel0.96793975
60* MP0005380_embryogenesis_phenotype0.96793975
61MP0009703_decreased_birth_body0.90651057
62* MP0003861_abnormal_nervous_system0.90420733
63MP0000538_abnormal_urinary_bladder0.90163587
64MP0000579_abnormal_nail_morphology0.89740451
65MP0003283_abnormal_digestive_organ0.89021170
66MP0005197_abnormal_uvea_morphology0.88828605
67MP0001340_abnormal_eyelid_morphology0.87709400
68MP0002160_abnormal_reproductive_system0.86645990
69MP0001697_abnormal_embryo_size0.84242843
70MP0004272_abnormal_basement_membrane0.83645830
71MP0002092_abnormal_eye_morphology0.82534138
72MP0005076_abnormal_cell_differentiation0.79299397
73MP0001270_distended_abdomen0.76839322
74MP0008789_abnormal_olfactory_epithelium0.75153485
75MP0002081_perinatal_lethality0.74847029
76MP0008007_abnormal_cellular_replicative0.73963179
77MP0001286_abnormal_eye_development0.72681332
78MP0002697_abnormal_eye_size0.71461456
79MP0002086_abnormal_extraembryonic_tissu0.70608785
80MP0002925_abnormal_cardiovascular_devel0.68336280
81MP0000350_abnormal_cell_proliferation0.67265407
82MP0010234_abnormal_vibrissa_follicle0.66698386
83MP0004957_abnormal_blastocyst_morpholog0.66374492
84MP0003111_abnormal_nucleus_morphology0.65399675
85MP0002088_abnormal_embryonic_growth/wei0.65021119
86MP0000462_abnormal_digestive_system0.64787478
87MP0002108_abnormal_muscle_morphology0.64571235
88MP0001346_abnormal_lacrimal_gland0.64068343
89MP0003077_abnormal_cell_cycle0.63842391
90MP0003984_embryonic_growth_retardation0.63817028
91MP0000477_abnormal_intestine_morphology0.62552989
92* MP0002080_prenatal_lethality0.60825566
93MP0002751_abnormal_autonomic_nervous0.59198313
94MP0008932_abnormal_embryonic_tissue0.57393595
95MP0002396_abnormal_hematopoietic_system0.55947076
96MP0000467_abnormal_esophagus_morphology0.55743696
97MP0009384_cardiac_valve_regurgitation0.55011484
98MP0010368_abnormal_lymphatic_system0.53656430
99MP0001175_abnormal_lung_morphology0.53053043
100MP0004134_abnormal_chest_morphology0.51219761

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)7.36146226
2Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)6.02763105
3Abnormality of the 4th metacarpal (HP:0010012)5.78361892
4Short 5th finger (HP:0009237)5.72622671
5Abnormality of the phalanges of the hallux (HP:0010057)5.64811583
6Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)5.51654992
7Broad distal phalanx of finger (HP:0009836)5.49687742
8Aplasia/Hypoplasia of the 5th finger (HP:0006262)5.33030627
9Abnormality of the middle phalanx of the 5th finger (HP:0004219)5.29942971
10Abnormality of the middle phalanges of the toes (HP:0010183)5.29540438
11Abnormality of the phalanges of the 5th finger (HP:0004213)4.91337454
12Ureteral stenosis (HP:0000071)4.61173198
13Short 1st metacarpal (HP:0010034)4.60189286
14Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.60189286
15Abnormality of the 2nd finger (HP:0004100)4.48320546
16Absent phalangeal crease (HP:0006109)4.33694014
17Ureteral obstruction (HP:0006000)4.31001444
18Abnormal umbilical cord blood vessels (HP:0011403)4.28471554
19Single umbilical artery (HP:0001195)4.28471554
20Abnormality of the fetal cardiovascular system (HP:0010948)4.28471554
21Short middle phalanx of finger (HP:0005819)4.20113383
22Abnormality of the 1st metacarpal (HP:0010009)4.04800033
23Esophageal atresia (HP:0002032)3.88105031
24Mesomelia (HP:0003027)3.87792011
25Abnormality of the distal phalanges of the toes (HP:0010182)3.86588254
26Symphalangism affecting the phalanges of the hand (HP:0009773)3.81916888
27Abnormal finger flexion creases (HP:0006143)3.64662909
28Deviation of the hallux (HP:0010051)3.64196581
29Abnormality of the distal phalanx of the thumb (HP:0009617)3.57541015
30Abnormality of the phalanges of the 2nd finger (HP:0009541)3.38219891
31Broad thumb (HP:0011304)3.36634741
32Cutaneous finger syndactyly (HP:0010554)3.26386190
33Carpal synostosis (HP:0009702)3.25336285
34Renal duplication (HP:0000075)3.22672174
35Short phalanx of the thumb (HP:0009660)3.21670351
36Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)3.18817071
37Ulnar deviation of finger (HP:0009465)3.15839607
38Bifid scrotum (HP:0000048)3.02418239
39Short 4th metacarpal (HP:0010044)3.02063218
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02063218
41Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.99559987
42Short hallux (HP:0010109)2.97638494
43Short metatarsal (HP:0010743)2.96832836
44Occipital encephalocele (HP:0002085)2.96437265
45Hallux valgus (HP:0001822)2.95156360
46Ectopic kidney (HP:0000086)2.94303253
47Cutaneous syndactyly (HP:0012725)2.87083948
48Septate vagina (HP:0001153)2.85458023
49Abnormality of the middle phalanges of the hand (HP:0009833)2.84784101
50Shallow orbits (HP:0000586)2.77814432
51Synostosis involving bones of the hand (HP:0004278)2.77316429
52Broad toe (HP:0001837)2.75305183
53Broad phalanges of the hand (HP:0009768)2.72478647
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.71394007
55Aplasia/Hypoplasia of the hallux (HP:0008362)2.70140164
56Abnormality of the intervertebral disk (HP:0005108)2.63069519
57Renal dysplasia (HP:0000110)2.59546480
58Broad finger (HP:0001500)2.59417845
59Fibular aplasia (HP:0002990)2.59166251
60Short clavicles (HP:0000894)2.56117686
61Broad phalanx (HP:0006009)2.51864904
62Preaxial foot polydactyly (HP:0001841)2.50785128
63Abnormal tarsal ossification (HP:0008369)2.50574260
64Abnormality of the umbilical cord (HP:0010881)2.45446137
65Synostosis of carpal bones (HP:0005048)2.44400260
66Aplasia/Hypoplasia of the clavicles (HP:0006710)2.44076340
67Broad long bones (HP:0005622)2.38739040
68Radial bowing (HP:0002986)2.37839299
69Asymmetry of the thorax (HP:0001555)2.36662707
70Abnormal ventriculo-arterial connection (HP:0011563)2.35378216
71Transposition of the great arteries (HP:0001669)2.35378216
72Abnormal connection of the cardiac segments (HP:0011545)2.35378216
73Deformed tarsal bones (HP:0008119)2.35337293
74Ulnar deviation of the hand or of fingers of the hand (HP:0001193)2.31545315
75Gastrointestinal atresia (HP:0002589)2.27068331
76Humeroradial synostosis (HP:0003041)2.24680615
77Synostosis involving the elbow (HP:0003938)2.24680615
78Hypoplasia of the radius (HP:0002984)2.13723636
79Abnormality of carpal bone ossification (HP:0006257)2.13706001
80Microglossia (HP:0000171)2.13469801
81Tracheal stenosis (HP:0002777)2.09972481
82Concave nail (HP:0001598)2.08995951
83Broad hallux (HP:0010055)2.08796033
84Coronal craniosynostosis (HP:0004440)2.05653850
85Selective tooth agenesis (HP:0001592)2.01073978
86Short thumb (HP:0009778)1.96788326
87Hepatoblastoma (HP:0002884)1.96624906
88Ulnar bowing (HP:0003031)1.95565165
89Abnormal ossification of hand bones (HP:0005921)1.95201242
90Abnormal foot bone ossification (HP:0010675)1.94366555
91Bowing of the arm (HP:0006488)1.92805877
92Bowed forearm bones (HP:0003956)1.92805877
93Partial duplication of the phalanx of hand (HP:0009999)1.89000372
94Tarsal synostosis (HP:0008368)1.87716916
95Abnormality of the proximal phalanges of the hand (HP:0009834)1.84814205
96Radioulnar synostosis (HP:0002974)1.83144888
97Spontaneous abortion (HP:0005268)1.81770176
98Asymmetric growth (HP:0100555)1.79870734
99Synostosis involving bones of the lower limbs (HP:0009138)1.75881556
100Synostosis involving bones of the feet (HP:0009140)1.75881556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK14.30476976
2LATS13.75523227
3MAP3K103.71475715
4LATS23.59501873
5MKNK23.07987336
6PDGFRA3.03302240
7DDR22.97110445
8TRIB32.80115657
9ERBB32.43354294
10CDC72.39282021
11PASK2.33203521
12PKN22.28939772
13EPHB22.27047107
14TLK12.18610625
15PTK62.11831275
16TTN1.84390988
17SRPK11.83102339
18PAK41.69482948
19FGFR21.67918804
20FGFR11.63482931
21TGFBR11.58426210
22CLK11.47915566
23TTK1.42410594
24STK31.39447075
25STK38L1.32917200
26ERBB21.22951568
27RIPK11.22764040
28CSNK1A1L1.20427849
29CDK61.13696116
30CDK81.10839696
31CDK71.08875293
32CSNK1G31.08817425
33PAK21.08598693
34CDK121.08584449
35NEK91.08215577
36PLK31.06897761
37FER1.06240632
38LRRK21.00189076
39MAP3K80.99907192
40NEK20.98821662
41ICK0.98003955
42CSNK1G10.97909460
43ALK0.96184714
44BMX0.93502485
45EEF2K0.91839593
46MTOR0.86228177
47BUB10.85255269
48RPS6KB20.85252469
49PDGFRB0.84017766
50TYRO30.79841698
51UHMK10.76549560
52KSR10.76442024
53ILK0.74318854
54PRKD30.72075413
55EPHA40.68089571
56CSNK1G20.65522139
57PLK10.63557020
58BRD40.63465579
59CDK40.62125037
60BRSK20.61010352
61MET0.60274465
62TAOK20.59945389
63WEE10.59660957
64CDK20.59009380
65TSSK60.58764990
66DYRK1B0.58251814
67CDK10.56910088
68PTK20.56743529
69CHEK20.53889455
70CSNK1E0.53782556
71DYRK30.53588760
72ADRBK10.52390862
73MAPK90.51324651
74ATR0.51175524
75CHEK10.50058582
76WNK10.48418445
77RPS6KA40.48026902
78TESK20.46191674
79AURKB0.45973105
80ATM0.45081765
81PLK20.42147564
82CDK140.40868250
83STK40.38035321
84CDK150.37280434
85ROCK20.37122874
86MAPK80.37011338
87CDK11A0.35064141
88CDK180.34579733
89SRC0.34304508
90PRKDC0.33473426
91AKT10.32897422
92MAPK10.32754980
93MAPK140.32734587
94PAK30.31880444
95STK380.31141641
96CSNK1D0.31133220
97CDK90.30779394
98MELK0.29467383
99NEK10.28989983
100DYRK20.28743087

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.74568796
2Hedgehog signaling pathway_Homo sapiens_hsa043403.94176067
3Hippo signaling pathway_Homo sapiens_hsa043903.51215081
4Spliceosome_Homo sapiens_hsa030403.24872520
5Cell cycle_Homo sapiens_hsa041102.57988381
6TGF-beta signaling pathway_Homo sapiens_hsa043502.50549012
7Proteoglycans in cancer_Homo sapiens_hsa052052.50510652
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.37355301
9Wnt signaling pathway_Homo sapiens_hsa043102.23134314
10MicroRNAs in cancer_Homo sapiens_hsa052062.01848812
11Melanogenesis_Homo sapiens_hsa049161.97912987
12Chronic myeloid leukemia_Homo sapiens_hsa052201.92622913
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.92577512
14RNA transport_Homo sapiens_hsa030131.90512904
15mRNA surveillance pathway_Homo sapiens_hsa030151.87636514
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.83272352
17Adherens junction_Homo sapiens_hsa045201.80100937
18Thyroid cancer_Homo sapiens_hsa052161.79285016
19Axon guidance_Homo sapiens_hsa043601.74001660
20HTLV-I infection_Homo sapiens_hsa051661.71564786
21DNA replication_Homo sapiens_hsa030301.64472298
22Oocyte meiosis_Homo sapiens_hsa041141.63784742
23Colorectal cancer_Homo sapiens_hsa052101.57397174
24Prostate cancer_Homo sapiens_hsa052151.54658067
25Bladder cancer_Homo sapiens_hsa052191.47380381
26Pathways in cancer_Homo sapiens_hsa052001.33395415
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31877750
28Selenocompound metabolism_Homo sapiens_hsa004501.29780129
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23642318
30Endometrial cancer_Homo sapiens_hsa052131.23141167
31Melanoma_Homo sapiens_hsa052181.22439454
32Systemic lupus erythematosus_Homo sapiens_hsa053221.22020836
33Base excision repair_Homo sapiens_hsa034101.21801209
34Focal adhesion_Homo sapiens_hsa045101.19550237
35Lysine degradation_Homo sapiens_hsa003101.17727362
36Tight junction_Homo sapiens_hsa045301.17185671
37Non-small cell lung cancer_Homo sapiens_hsa052231.16775838
38Mismatch repair_Homo sapiens_hsa034301.13332284
39Glioma_Homo sapiens_hsa052141.13237113
40Viral myocarditis_Homo sapiens_hsa054161.13182609
41Ribosome_Homo sapiens_hsa030101.10468827
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06467947
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.04318458
44Notch signaling pathway_Homo sapiens_hsa043301.02855662
45Alcoholism_Homo sapiens_hsa050340.99611582
46Small cell lung cancer_Homo sapiens_hsa052220.97187672
47Viral carcinogenesis_Homo sapiens_hsa052030.97051504
48Gap junction_Homo sapiens_hsa045400.95947518
49Rap1 signaling pathway_Homo sapiens_hsa040150.91796655
50RNA degradation_Homo sapiens_hsa030180.82769450
51Renal cell carcinoma_Homo sapiens_hsa052110.81641109
52ECM-receptor interaction_Homo sapiens_hsa045120.79044954
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77250153
54Pancreatic cancer_Homo sapiens_hsa052120.75847646
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75506390
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73830689
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70416159
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69802052
59Estrogen signaling pathway_Homo sapiens_hsa049150.68362625
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.67336901
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67199173
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66573042
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65985732
64One carbon pool by folate_Homo sapiens_hsa006700.64211571
65Hepatitis B_Homo sapiens_hsa051610.63541090
66p53 signaling pathway_Homo sapiens_hsa041150.61357542
67Herpes simplex infection_Homo sapiens_hsa051680.59684462
68Nucleotide excision repair_Homo sapiens_hsa034200.58265329
69Epstein-Barr virus infection_Homo sapiens_hsa051690.57222325
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54794401
71Dilated cardiomyopathy_Homo sapiens_hsa054140.51448697
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49731160
73VEGF signaling pathway_Homo sapiens_hsa043700.46906920
74ErbB signaling pathway_Homo sapiens_hsa040120.45672362
75mTOR signaling pathway_Homo sapiens_hsa041500.42956802
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39588331
77MAPK signaling pathway_Homo sapiens_hsa040100.39588243
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39494797
79Non-homologous end-joining_Homo sapiens_hsa034500.38271442
80FoxO signaling pathway_Homo sapiens_hsa040680.36609660
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34870061
82Insulin signaling pathway_Homo sapiens_hsa049100.32976995
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.32957634
84Amoebiasis_Homo sapiens_hsa051460.31650917
85Protein digestion and absorption_Homo sapiens_hsa049740.30544375
86Shigellosis_Homo sapiens_hsa051310.30017172
87GnRH signaling pathway_Homo sapiens_hsa049120.29279102
88Thyroid hormone synthesis_Homo sapiens_hsa049180.28757377
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.27385486
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26964782
91AMPK signaling pathway_Homo sapiens_hsa041520.26436849
92Long-term potentiation_Homo sapiens_hsa047200.26397568
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26287287
94Cocaine addiction_Homo sapiens_hsa050300.24197818
95Glucagon signaling pathway_Homo sapiens_hsa049220.23634458
96Ras signaling pathway_Homo sapiens_hsa040140.23448394
97Long-term depression_Homo sapiens_hsa047300.22632776
98Insulin resistance_Homo sapiens_hsa049310.22533613
99Retinol metabolism_Homo sapiens_hsa008300.21988536
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21873741

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