HOXD13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesenchymal cell apoptotic process (GO:2001053)7.01539623
2embryonic forelimb morphogenesis (GO:0035115)6.53624337
3forelimb morphogenesis (GO:0035136)6.50523558
4embryonic skeletal joint morphogenesis (GO:0060272)6.40264958
5lymph vessel development (GO:0001945)6.10806466
6* branching involved in prostate gland morphogenesis (GO:0060442)5.98395569
7ribosomal small subunit biogenesis (GO:0042274)5.94323496
8maturation of SSU-rRNA (GO:0030490)5.86041204
9peripheral nervous system neuron development (GO:0048935)5.84531910
10proximal/distal pattern formation (GO:0009954)5.81525290
11lateral sprouting from an epithelium (GO:0060601)5.28489759
12cranial suture morphogenesis (GO:0060363)5.19448028
13mesenchymal cell proliferation (GO:0010463)5.13786085
14endothelial cell morphogenesis (GO:0001886)5.08029569
15outer ear morphogenesis (GO:0042473)5.07682560
16positive regulation of cartilage development (GO:0061036)4.92983824
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.88144925
18negative regulation of DNA repair (GO:0045738)4.79298194
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.79087641
20positive regulation of chondrocyte differentiation (GO:0032332)4.78542737
21regulation of mammary gland epithelial cell proliferation (GO:0033599)4.75347796
22limb morphogenesis (GO:0035108)4.74704830
23appendage morphogenesis (GO:0035107)4.74704830
24hindlimb morphogenesis (GO:0035137)4.74020659
25cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.69071413
26midgut development (GO:0007494)4.63241830
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.60719038
28DNA replication checkpoint (GO:0000076)4.58781976
29* embryonic digit morphogenesis (GO:0042733)4.56554559
30embryonic limb morphogenesis (GO:0030326)4.56479546
31embryonic appendage morphogenesis (GO:0035113)4.56479546
32cell migration involved in heart development (GO:0060973)4.56415757
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.50498863
34bone trabecula formation (GO:0060346)4.41680272
35craniofacial suture morphogenesis (GO:0097094)4.36433785
36embryonic cranial skeleton morphogenesis (GO:0048701)4.29851340
37paraxial mesoderm development (GO:0048339)4.23758111
38viral transcription (GO:0019083)4.22647519
39positive regulation of transcription regulatory region DNA binding (GO:2000679)4.22193766
40heterochromatin organization (GO:0070828)4.21671615
41regulation of chondrocyte differentiation (GO:0032330)4.16259439
42embryonic hindlimb morphogenesis (GO:0035116)4.14594173
43organ induction (GO:0001759)4.12901547
44negative regulation of mRNA processing (GO:0050686)4.10103340
45regulation of heart morphogenesis (GO:2000826)4.09245473
46eyelid development in camera-type eye (GO:0061029)4.08841638
47regulation of transforming growth factor beta2 production (GO:0032909)4.07411003
48regulation of cartilage development (GO:0061035)4.05565575
49translational termination (GO:0006415)4.02702311
50uterus development (GO:0060065)4.00047225
51* male genitalia development (GO:0030539)3.99506944
52DNA unwinding involved in DNA replication (GO:0006268)3.99243771
53negative regulation of chondrocyte differentiation (GO:0032331)3.99149337
54chondrocyte proliferation (GO:0035988)3.98091282
55embryonic heart tube development (GO:0035050)3.93618435
56negative regulation of RNA splicing (GO:0033119)3.88413176
57hippo signaling (GO:0035329)3.86025513
58negative regulation of axon extension involved in axon guidance (GO:0048843)3.85692606
59* prostate gland epithelium morphogenesis (GO:0060740)3.83456327
60middle ear morphogenesis (GO:0042474)3.81647614
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.78933999
62body morphogenesis (GO:0010171)3.76522157
63polarized epithelial cell differentiation (GO:0030859)3.73378515
64sequestering of extracellular ligand from receptor (GO:0035581)3.73235346
65regulation of mitochondrial translation (GO:0070129)3.72634281
66ribosomal large subunit biogenesis (GO:0042273)3.69968071
67DNA strand elongation involved in DNA replication (GO:0006271)3.69805280
68thyroid gland development (GO:0030878)3.69496934
69ribonucleoprotein complex biogenesis (GO:0022613)3.67685495
70Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.64641186
71mitotic sister chromatid cohesion (GO:0007064)3.63106313
72DNA strand elongation (GO:0022616)3.62604533
73regulation of organ formation (GO:0003156)3.61142327
74nuclear pore complex assembly (GO:0051292)3.58900285
75translational elongation (GO:0006414)3.58472857
76mitotic chromosome condensation (GO:0007076)3.56953958
77nuclear pore organization (GO:0006999)3.56129583
78ribosomal small subunit assembly (GO:0000028)3.55525886
79endocardial cushion development (GO:0003197)3.55329133
80DNA replication initiation (GO:0006270)3.54890575
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54747955
82cochlea morphogenesis (GO:0090103)3.54293171
83G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.53558162
84regulation of establishment of planar polarity (GO:0090175)3.53316895
85neuron projection extension involved in neuron projection guidance (GO:1902284)3.52585152
86axon extension involved in axon guidance (GO:0048846)3.52585152
87negative regulation of mRNA metabolic process (GO:1903312)3.51317667
88outflow tract septum morphogenesis (GO:0003148)3.49702399
89notochord development (GO:0030903)3.49205976
90cell surface receptor signaling pathway involved in heart development (GO:0061311)3.48474933
91collagen fibril organization (GO:0030199)3.47707145
92cartilage morphogenesis (GO:0060536)3.47439113
93mesenchyme morphogenesis (GO:0072132)3.46615513
94establishment of planar polarity (GO:0001736)3.46572917
95establishment of tissue polarity (GO:0007164)3.46572917
96neuron fate specification (GO:0048665)3.45147863
97regulation of chromatin binding (GO:0035561)3.44776217
98protein complex localization (GO:0031503)3.44481412
99glucocorticoid receptor signaling pathway (GO:0042921)3.42018313
100positive regulation of epithelial to mesenchymal transition (GO:0010718)3.41540501
101cell proliferation involved in metanephros development (GO:0072203)3.40809609
102rRNA processing (GO:0006364)3.39824093
103chondrocyte development (GO:0002063)3.38395975
104positive regulation of mesenchymal cell proliferation (GO:0002053)3.37358417
105protein localization to chromosome, centromeric region (GO:0071459)3.37355526
106mitotic sister chromatid segregation (GO:0000070)3.35688717
107non-canonical Wnt signaling pathway (GO:0035567)3.35521644
108SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.34522905
109formation of translation preinitiation complex (GO:0001731)3.32834380
110viral mRNA export from host cell nucleus (GO:0046784)3.31991173
111negative regulation of cartilage development (GO:0061037)3.31847298
112regulation of translational fidelity (GO:0006450)3.29558455
113mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.29538473
114cellular protein complex localization (GO:0034629)3.28644999
115head development (GO:0060322)3.27608610
116dorsal/ventral axis specification (GO:0009950)3.27350084
117cranial nerve morphogenesis (GO:0021602)3.27227185
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24657026
119cotranslational protein targeting to membrane (GO:0006613)3.24455255
120muscle cell fate commitment (GO:0042693)3.23040767
121rRNA metabolic process (GO:0016072)3.22655739
122lung-associated mesenchyme development (GO:0060484)3.21356295
123telomere maintenance via semi-conservative replication (GO:0032201)3.20870175
124protein targeting to ER (GO:0045047)3.20566051
125translational initiation (GO:0006413)3.19434845
126negative regulation of embryonic development (GO:0045992)3.18214163
127endocardial cushion morphogenesis (GO:0003203)3.16622385
128negative regulation of catenin import into nucleus (GO:0035414)3.16452347
129embryonic skeletal system morphogenesis (GO:0048704)3.15126160
130mesenchymal-epithelial cell signaling (GO:0060638)3.14843873
131viral life cycle (GO:0019058)3.13442857
132rRNA transcription (GO:0009303)3.12073305
133anterior/posterior axis specification, embryo (GO:0008595)3.11948621
134regulation of mesenchymal cell proliferation (GO:0010464)3.11521332
135negative regulation of axon guidance (GO:1902668)3.10315690
136cellular protein complex disassembly (GO:0043624)3.09897252
137pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.09174402
138regulation of cardioblast proliferation (GO:0003264)3.09152217
139regulation of secondary heart field cardioblast proliferation (GO:0003266)3.09152217
140sister chromatid segregation (GO:0000819)3.06905151
141convergent extension (GO:0060026)3.06303287
142establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06193479
143regulation of cellular senescence (GO:2000772)3.05480338
144anatomical structure regression (GO:0060033)3.05324875
145ventricular septum development (GO:0003281)3.03998799
146regulation of translational termination (GO:0006449)3.02734370
147folic acid-containing compound biosynthetic process (GO:0009396)3.01914761
148pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.99557118
149pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.99531980
150muscle organ morphogenesis (GO:0048644)2.99264194
151mammary gland epithelial cell differentiation (GO:0060644)2.98588290
152spliceosomal tri-snRNP complex assembly (GO:0000244)2.98241771
153positive regulation of smoothened signaling pathway (GO:0045880)2.96929794
154spliceosomal snRNP assembly (GO:0000387)2.96101011
155ribosome biogenesis (GO:0042254)2.95982958
156protein localization to endoplasmic reticulum (GO:0070972)2.95059330
157termination of RNA polymerase II transcription (GO:0006369)2.94275990
158organ formation (GO:0048645)2.90689396
159* reproductive system development (GO:0061458)2.90489789
160folic acid metabolic process (GO:0046655)2.89502608
161pseudouridine synthesis (GO:0001522)2.89420483
162cardiac muscle cell proliferation (GO:0060038)2.88622983
163protein complex disassembly (GO:0043241)2.88219529
164mitotic metaphase plate congression (GO:0007080)2.87554371
165UTP biosynthetic process (GO:0006228)2.87492048
166epithelial to mesenchymal transition (GO:0001837)2.86817344
167regulation of sister chromatid cohesion (GO:0007063)2.84534382
168coronary vasculature morphogenesis (GO:0060977)2.83381118
169cellular component biogenesis (GO:0044085)2.83011418
170purine nucleobase biosynthetic process (GO:0009113)2.81445459
171positive regulation of hormone biosynthetic process (GO:0046886)2.80871631
172regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.80579089
173branching involved in ureteric bud morphogenesis (GO:0001658)2.79288855
174mesenchyme development (GO:0060485)2.78596072
175kidney mesenchyme development (GO:0072074)2.77634879
176protein localization to kinetochore (GO:0034501)2.77558717
177regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.77414944
178guanosine-containing compound biosynthetic process (GO:1901070)2.76733772
179IMP biosynthetic process (GO:0006188)2.75511956
180regulation of cardioblast differentiation (GO:0051890)2.75215863
181CTP metabolic process (GO:0046036)2.74819318
182CTP biosynthetic process (GO:0006241)2.74819318
183chaperone-mediated protein transport (GO:0072321)2.74771941
184pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.74405970
185mitotic nuclear envelope disassembly (GO:0007077)2.74017624
186ventricular trabecula myocardium morphogenesis (GO:0003222)2.73709764
187nucleobase biosynthetic process (GO:0046112)2.73287750
188macromolecular complex disassembly (GO:0032984)2.72171364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.19896021
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.72574318
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.71586730
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.40688520
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39476811
6XRN2_22483619_ChIP-Seq_HELA_Human3.28793365
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.26792835
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.18442670
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.10002871
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.05426591
11STAT6_21828071_ChIP-Seq_BEAS2B_Human3.02892968
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97762554
13* TP63_19390658_ChIP-ChIP_HaCaT_Human2.90822716
14E2F7_22180533_ChIP-Seq_HELA_Human2.85987231
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.81017567
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72622103
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.71557304
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.69752990
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.69526363
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.67799888
21TTF2_22483619_ChIP-Seq_HELA_Human2.64083763
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.63102737
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62040805
24* TP53_20018659_ChIP-ChIP_R1E_Mouse2.61478173
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60673077
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60140419
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.53412911
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50059114
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48356135
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46264366
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.45033536
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41667569
33ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28111795
34* EED_16625203_ChIP-ChIP_MESCs_Mouse2.23060774
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19615086
36* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16970075
37* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12686164
38ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11289563
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11059800
40* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09429120
41* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09429120
42DCP1A_22483619_ChIP-Seq_HELA_Human2.06792004
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.99524639
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98945036
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.98278714
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97210525
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97082163
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.96949071
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.94711191
50* EZH2_27304074_Chip-Seq_ESCs_Mouse1.92977225
51CLOCK_20551151_ChIP-Seq_293T_Human1.88444553
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.88351219
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.88240321
54KDM5A_27292631_Chip-Seq_BREAST_Human1.87249551
55GABP_19822575_ChIP-Seq_HepG2_Human1.85691495
56* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83855647
57AR_21909140_ChIP-Seq_LNCAP_Human1.81804739
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79331043
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79065960
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.79013312
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77606609
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76507414
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.75682793
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71148835
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.68187135
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68137072
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.68108166
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67918055
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.67769789
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67658869
71* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67438294
72* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66507027
73* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64250298
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63935237
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62509996
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62319616
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62205987
78* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62004867
79* CBX2_27304074_Chip-Seq_ESCs_Mouse1.61944603
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57858479
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57121142
82* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55245986
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53720458
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53092621
85* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51946548
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51327961
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50875787
88* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50545402
89* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50460703
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49835249
91CIITA_25753668_ChIP-Seq_RAJI_Human1.48776258
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48664686
93* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46294264
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46281890
95* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45828530
96* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41096458
97* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40861869
98VDR_21846776_ChIP-Seq_THP-1_Human1.39020678
99BRD4_25478319_ChIP-Seq_HGPS_Human1.36745900
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.35621110
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35180878
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33971088
103FOXP3_21729870_ChIP-Seq_TREG_Human1.33745171
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32740093
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31865643
106* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31732019
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31500887
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31225366
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30935472
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.28604787
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.27876022
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27027580
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26099204
114CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25962621
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25934648
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.22691327
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.22346873
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21410807
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21402776
120VDR_23849224_ChIP-Seq_CD4+_Human1.20091331
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20046841
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19466152
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18269308
124* NANOG_16153702_ChIP-ChIP_HESCs_Human1.18018133
125SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17813863
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17771907
127* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17369060
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15054145
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14114450
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14049728
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13589109
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13094946
133TFEB_21752829_ChIP-Seq_HELA_Human1.12235284
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11968137
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10986282
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10946649
137ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10436812
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10365851
139NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10079609
140CHD1_26751641_Chip-Seq_LNCaP_Human1.09795273
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09541033
142KDM2B_26808549_Chip-Seq_DND41_Human1.09203348
143FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08505265
144TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07719842
145SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07654938
146HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07644368
147ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07240398
148MYC_22102868_ChIP-Seq_BL_Human1.06744092
149KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06407404
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06197430
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06152078
152KDM2B_26808549_Chip-Seq_K562_Human1.05370990
153NANOG_21062744_ChIP-ChIP_HESCs_Human1.05004030
154KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03423958
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03423958
156KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03423958
157TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02687590
158SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01669095
159SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01669095
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01645918
161MYC_18940864_ChIP-ChIP_HL60_Human1.01069527
162RNF2_27304074_Chip-Seq_NSC_Mouse0.99268914
163EP300_21415370_ChIP-Seq_HL-1_Mouse0.99165418
164ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98718160
165HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98307484
166* SOX2_16153702_ChIP-ChIP_HESCs_Human0.96830972
167* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95216721
168ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95151218
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95125398
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94849348
171FOXP1_21924763_ChIP-Seq_HESCs_Human0.93906672
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89973724
173PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89703728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0009053_abnormal_anal_canal6.61153697
2MP0000537_abnormal_urethra_morphology5.86955859
3MP0001346_abnormal_lacrimal_gland4.14980052
4MP0003693_abnormal_embryo_hatching3.63748952
5MP0003111_abnormal_nucleus_morphology3.50140140
6MP0003315_abnormal_perineum_morphology3.41131728
7MP0005503_abnormal_tendon_morphology3.35027256
8MP0010030_abnormal_orbit_morphology3.34322252
9MP0009250_abnormal_appendicular_skeleto3.07209908
10MP0003123_paternal_imprinting3.03649870
11MP0003385_abnormal_body_wall3.02434730
12MP0008438_abnormal_cutaneous_collagen2.98094676
13MP0005367_renal/urinary_system_phenotyp2.92567185
14MP0000516_abnormal_urinary_system2.92567185
15MP0010094_abnormal_chromosome_stability2.91905220
16MP0003705_abnormal_hypodermis_morpholog2.87276263
17* MP0005187_abnormal_penis_morphology2.83622692
18MP0003077_abnormal_cell_cycle2.79072546
19* MP0003937_abnormal_limbs/digits/tail_de2.79053233
20MP0002163_abnormal_gland_morphology2.78186268
21MP0003122_maternal_imprinting2.63444896
22MP0000678_abnormal_parathyroid_gland2.51255074
23MP0008932_abnormal_embryonic_tissue2.44749006
24MP0004957_abnormal_blastocyst_morpholog2.42627853
25MP0008057_abnormal_DNA_replication2.36942229
26MP0003942_abnormal_urinary_system2.36521365
27MP0006054_spinal_hemorrhage2.24023625
28MP0002234_abnormal_pharynx_morphology2.20578512
29MP0002877_abnormal_melanocyte_morpholog2.17457052
30MP0008058_abnormal_DNA_repair2.15239158
31MP0001188_hyperpigmentation2.11564094
32MP0002282_abnormal_trachea_morphology2.08706880
33* MP0002932_abnormal_joint_morphology1.98157859
34MP0000428_abnormal_craniofacial_morphol1.84143199
35* MP0002115_abnormal_skeleton_extremities1.83923867
36MP0000049_abnormal_middle_ear1.80025738
37MP0005508_abnormal_skeleton_morphology1.77265815
38* MP0002109_abnormal_limb_morphology1.73894692
39MP0003121_genomic_imprinting1.73487960
40MP0002009_preneoplasia1.73456111
41MP0003283_abnormal_digestive_organ1.73289171
42MP0005275_abnormal_skin_tensile1.72695653
43MP0001730_embryonic_growth_arrest1.67953005
44MP0008007_abnormal_cellular_replicative1.67816349
45MP0000566_synostosis1.66926640
46MP0003941_abnormal_skin_development1.66728680
47MP0000534_abnormal_ureter_morphology1.65583818
48MP0000733_abnormal_muscle_development1.64859801
49MP0005248_abnormal_Harderian_gland1.60151142
50MP0001849_ear_inflammation1.59252769
51MP0010234_abnormal_vibrissa_follicle1.58981760
52MP0002249_abnormal_larynx_morphology1.58648080
53MP0001270_distended_abdomen1.57829749
54MP0003755_abnormal_palate_morphology1.55669749
55MP0002822_catalepsy1.54793299
56MP0010307_abnormal_tumor_latency1.52915189
57MP0005379_endocrine/exocrine_gland_phen1.50088829
58MP0000681_abnormal_thyroid_gland1.49492254
59MP0004858_abnormal_nervous_system1.41199779
60MP0003567_abnormal_fetal_cardiomyocyte1.40601630
61MP0005623_abnormal_meninges_morphology1.39114146
62MP0009384_cardiac_valve_regurgitation1.38569477
63MP0003115_abnormal_respiratory_system1.38484823
64MP0000538_abnormal_urinary_bladder1.37209947
65MP0010352_gastrointestinal_tract_polyps1.31097231
66MP0002938_white_spotting1.30829938
67MP0003935_abnormal_craniofacial_develop1.30219064
68* MP0002114_abnormal_axial_skeleton1.28270823
69MP0000163_abnormal_cartilage_morphology1.25846535
70MP0002116_abnormal_craniofacial_bone1.25341953
71MP0001299_abnormal_eye_distance/1.24888192
72MP0002233_abnormal_nose_morphology1.22328124
73MP0005257_abnormal_intraocular_pressure1.21711104
74MP0003279_aneurysm1.19657729
75MP0004272_abnormal_basement_membrane1.18030736
76MP0005389_reproductive_system_phenotype1.17060727
77MP0003119_abnormal_digestive_system1.15024578
78MP0005076_abnormal_cell_differentiation1.14284383
79MP0003786_premature_aging1.14154430
80MP0000313_abnormal_cell_death1.13101289
81MP0002277_abnormal_respiratory_mucosa1.12284009
82MP0000432_abnormal_head_morphology1.12218792
83* MP0002113_abnormal_skeleton_development1.11857035
84MP0004185_abnormal_adipocyte_glucose1.11368712
85MP0000762_abnormal_tongue_morphology1.10029766
86MP0002177_abnormal_outer_ear1.09294834
87MP0002111_abnormal_tail_morphology1.08819745
88* MP0002085_abnormal_embryonic_tissue1.07283993
89MP0000462_abnormal_digestive_system1.05444333
90MP0009379_abnormal_foot_pigmentation1.04840296
91MP0005197_abnormal_uvea_morphology1.02801810
92MP0000579_abnormal_nail_morphology1.01497388
93MP0002084_abnormal_developmental_patter0.99920499
94* MP0002080_prenatal_lethality0.99916901
95MP0004197_abnormal_fetal_growth/weight/0.99242561
96MP0000003_abnormal_adipose_tissue0.93350529
97MP0002751_abnormal_autonomic_nervous0.93131524
98MP0002210_abnormal_sex_determination0.92649091
99* MP0000767_abnormal_smooth_muscle0.91107314
100MP0001293_anophthalmia0.88133088
101MP0001958_emphysema0.86135494
102MP0001879_abnormal_lymphatic_vessel0.86034038
103MP0006292_abnormal_olfactory_placode0.85961568
104MP0001919_abnormal_reproductive_system0.85829481
105* MP0001672_abnormal_embryogenesis/_devel0.85302580
106* MP0005380_embryogenesis_phenotype0.85302580
107MP0001340_abnormal_eyelid_morphology0.84395388
108MP0004134_abnormal_chest_morphology0.83659647
109MP0009703_decreased_birth_body0.82317497
110MP0010678_abnormal_skin_adnexa0.81101011
111MP0003938_abnormal_ear_development0.80915883
112MP0002896_abnormal_bone_mineralization0.80889285
113MP0009333_abnormal_splenocyte_physiolog0.80834334
114MP0005670_abnormal_white_adipose0.80156823
115MP0009672_abnormal_birth_weight0.79735618
116MP0002092_abnormal_eye_morphology0.79536874
117* MP0001145_abnormal_male_reproductive0.78459119
118MP0002060_abnormal_skin_morphology0.77947052
119MP0000467_abnormal_esophagus_morphology0.76788433
120MP0002697_abnormal_eye_size0.76306462
121MP0000631_abnormal_neuroendocrine_gland0.75783478
122* MP0003861_abnormal_nervous_system0.75649560
123MP0001697_abnormal_embryo_size0.75199681
124MP0005646_abnormal_pituitary_gland0.74845796
125MP0002098_abnormal_vibrissa_morphology0.74507007
126MP0002086_abnormal_extraembryonic_tissu0.73415139
127MP0002925_abnormal_cardiovascular_devel0.73400030
128MP0000759_abnormal_skeletal_muscle0.72196149
129MP0002108_abnormal_muscle_morphology0.71173450
130MP0005023_abnormal_wound_healing0.71113478
131MP0004264_abnormal_extraembryonic_tissu0.70056561
132MP0004233_abnormal_muscle_weight0.68182753
133MP0008789_abnormal_olfactory_epithelium0.66729076
134MP0005390_skeleton_phenotype0.65913177
135MP0001286_abnormal_eye_development0.63544614
136MP0000350_abnormal_cell_proliferation0.63144634
137MP0002081_perinatal_lethality0.62353076
138MP0002160_abnormal_reproductive_system0.61906443
139MP0005193_abnormal_anterior_eye0.60137407
140MP0000383_abnormal_hair_follicle0.59653086
141MP0003091_abnormal_cell_migration0.59452884
142MP0002088_abnormal_embryonic_growth/wei0.59232768
143MP0003984_embryonic_growth_retardation0.56666072

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)6.48224051
2Short 1st metacarpal (HP:0010034)6.48224051
3Abnormality of the 2nd finger (HP:0004100)6.21963788
4Abnormality of the 1st metacarpal (HP:0010009)5.77603265
5Mesomelia (HP:0003027)5.05374295
6Congenital malformation of the right heart (HP:0011723)4.67112110
7Double outlet right ventricle (HP:0001719)4.67112110
8Short phalanx of the thumb (HP:0009660)4.55523329
9Abnormality of the phalanges of the 2nd finger (HP:0009541)4.44066035
10* Short 5th finger (HP:0009237)4.33565016
11Shallow orbits (HP:0000586)4.32421734
12Aplasia/Hypoplasia of the sacrum (HP:0008517)4.31034306
13Short hallux (HP:0010109)4.14966325
14Periauricular skin pits (HP:0100277)4.07309491
15Preauricular pit (HP:0004467)4.07309491
16Septate vagina (HP:0001153)4.01913709
17* Aplasia/Hypoplasia of the 5th finger (HP:0006262)4.00107651
18Aplastic anemia (HP:0001915)3.96334336
19Abnormal number of incisors (HP:0011064)3.95692517
20Birth length less than 3rd percentile (HP:0003561)3.90693748
21Abnormal tarsal ossification (HP:0008369)3.81994988
22Aplasia/Hypoplasia of the hallux (HP:0008362)3.81430080
23Unilateral renal agenesis (HP:0000122)3.80128857
24Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.74200063
25* Deviation of the hallux (HP:0010051)3.65685042
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.58833987
27Short 4th metacarpal (HP:0010044)3.58833987
28Fibular aplasia (HP:0002990)3.54533166
29Abnormality of the aortic arch (HP:0012303)3.52256592
30Hypoplastic left heart (HP:0004383)3.49172714
31Synostosis of carpal bones (HP:0005048)3.47835837
32Microretrognathia (HP:0000308)3.43298816
33Calcaneovalgus deformity (HP:0001848)3.41871816
34Protrusio acetabuli (HP:0003179)3.37263136
35* Short middle phalanx of finger (HP:0005819)3.32085056
36* Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.29147799
37Broad toe (HP:0001837)3.25025864
38Renal duplication (HP:0000075)3.24970147
39Rectal fistula (HP:0100590)3.24562377
40Rectovaginal fistula (HP:0000143)3.24562377
41Radial bowing (HP:0002986)3.23825884
42* Transposition of the great arteries (HP:0001669)3.19980307
43* Abnormal connection of the cardiac segments (HP:0011545)3.19980307
44* Abnormal ventriculo-arterial connection (HP:0011563)3.19980307
45Premature rupture of membranes (HP:0001788)3.18047147
46Progressive muscle weakness (HP:0003323)3.16108750
47Intestinal fistula (HP:0100819)3.15703775
48Truncus arteriosus (HP:0001660)3.12625478
49Abnormality of carpal bone ossification (HP:0006257)3.09258751
50* Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.06492082
51Rectal prolapse (HP:0002035)3.05420440
52Abnormal foot bone ossification (HP:0010675)3.02717716
53* Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.98395735
54Atresia of the external auditory canal (HP:0000413)2.95353316
55Asymmetry of the thorax (HP:0001555)2.94446324
56Coronal craniosynostosis (HP:0004440)2.93020096
57Skin pits (HP:0100276)2.92163696
58* Abnormality of the 4th metacarpal (HP:0010012)2.91661408
59Abnormality of chromosome segregation (HP:0002916)2.89577834
60Abnormal ossification of hand bones (HP:0005921)2.84458651
61Microglossia (HP:0000171)2.83578404
62* Abnormality of the phalanges of the 5th finger (HP:0004213)2.82213852
63* Ureteral stenosis (HP:0000071)2.82163085
64* Carpal synostosis (HP:0009702)2.79162220
65Buphthalmos (HP:0000557)2.78672780
66Tarsal synostosis (HP:0008368)2.77682230
67Spontaneous abortion (HP:0005268)2.76839735
68Cutaneous melanoma (HP:0012056)2.76166632
69Deformed tarsal bones (HP:0008119)2.75082480
70* Abnormality of the phalanges of the hallux (HP:0010057)2.73799299
71Vaginal fistula (HP:0004320)2.71160002
72Breast hypoplasia (HP:0003187)2.70105534
73Hypoplastic heart (HP:0001961)2.66399924
74* Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.65915934
75* Short middle phalanx of the 5th finger (HP:0004220)2.65272976
76Abnormality of the proximal phalanges of the hand (HP:0009834)2.64995570
77* Ureteral obstruction (HP:0006000)2.64504540
78* Hallux valgus (HP:0001822)2.63890987
79Reticulocytopenia (HP:0001896)2.63255305
80Bowed forearm bones (HP:0003956)2.62007340
81Bowing of the arm (HP:0006488)2.62007340
82* Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.60606140
83Broad hallux (HP:0010055)2.60142310
84Macrocytic anemia (HP:0001972)2.59353428
85Microvesicular hepatic steatosis (HP:0001414)2.56104788
86Synostosis involving bones of the lower limbs (HP:0009138)2.54450055
87Synostosis involving bones of the feet (HP:0009140)2.54450055
88Abnormal hand bone ossification (HP:0010660)2.54226152
89Preauricular skin tag (HP:0000384)2.50119075
90Synostosis involving the elbow (HP:0003938)2.49222607
91Humeroradial synostosis (HP:0003041)2.49222607
92* Abnormality of the fetal cardiovascular system (HP:0010948)2.48583629
93* Abnormal umbilical cord blood vessels (HP:0011403)2.48583629
94* Single umbilical artery (HP:0001195)2.48583629
95* Ulnar deviation of finger (HP:0009465)2.48146030
96Ulnar bowing (HP:0003031)2.46360702
97Turricephaly (HP:0000262)2.46153127
98* Abnormality of the middle phalanges of the hand (HP:0009833)2.43650538
99* Short metatarsal (HP:0010743)2.42036354
100Deviation of the thumb (HP:0009603)2.41986944
101Midline defect of the nose (HP:0004122)2.40933019
102Partial duplication of thumb phalanx (HP:0009944)2.40584114
103Abnormality of the parietal bone (HP:0002696)2.39958223
104Concave nail (HP:0001598)2.39829626
105Partial duplication of the phalanx of hand (HP:0009999)2.38998442
106Proximal placement of thumb (HP:0009623)2.38959563
107* Synostosis involving bones of the hand (HP:0004278)2.38721060
108Selective tooth agenesis (HP:0001592)2.38517554
109Aortic dissection (HP:0002647)2.36848592
110Hyperthyroidism (HP:0000836)2.34277987
111Abnormality of the calcaneus (HP:0008364)2.32969138
112Facial cleft (HP:0002006)2.32602147
113Duplication of thumb phalanx (HP:0009942)2.32440277
114* Abnormality of the middle phalanges of the toes (HP:0010183)2.28467400
115Skin tags (HP:0010609)2.26603196
116Broad metatarsal (HP:0001783)2.22830806
117Testicular atrophy (HP:0000029)2.20806975
118Ragged-red muscle fibers (HP:0003200)2.19785360
119* Broad thumb (HP:0011304)2.19778249
120Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17873560
121Abnormality of cells of the erythroid lineage (HP:0012130)2.14711163
122Trismus (HP:0000211)2.13665131
123Wrist flexion contracture (HP:0001239)2.13195062
124High anterior hairline (HP:0009890)2.10005958
125Hepatoblastoma (HP:0002884)2.09828413
126Optic nerve coloboma (HP:0000588)2.07428601
127Bladder diverticulum (HP:0000015)2.07274634
128Patellar aplasia (HP:0006443)2.06685992
129Abnormality of the parathyroid morphology (HP:0011766)2.06001589
130Mitral valve prolapse (HP:0001634)2.04949551
131Aplasia/Hypoplasia of the patella (HP:0006498)2.03701724
132Abnormality of the columella (HP:0009929)2.03057497
133Hypoplasia of the iris (HP:0007676)2.02591082
134Abnormality of the anterior horn cell (HP:0006802)2.01799688
135Degeneration of anterior horn cells (HP:0002398)2.01799688
136Chromsome breakage (HP:0040012)2.00732798
137Abnormal number of erythroid precursors (HP:0012131)1.97643082
138Cleft eyelid (HP:0000625)1.97376596
139Posterior embryotoxon (HP:0000627)1.97121001
140Abnormal delivery (HP:0001787)1.97039538
141Hypoplastic labia majora (HP:0000059)1.96818641
142Wide anterior fontanel (HP:0000260)1.96380096
143Spinal cord lesions (HP:0100561)1.95952129
144Syringomyelia (HP:0003396)1.95952129
145Squamous cell carcinoma (HP:0002860)1.94399981
146Lip pit (HP:0100267)1.93334009
147Atrophic scars (HP:0001075)1.93182336
148Self-mutilation (HP:0000742)1.92656559
149Bicornuate uterus (HP:0000813)1.91176584
150Gout (HP:0001997)1.90883027
151* Absent phalangeal crease (HP:0006109)1.90235059
152Sacral dimple (HP:0000960)1.89897929
153* Broad long bones (HP:0005622)1.89279427
154Camptodactyly of toe (HP:0001836)1.87798742
155Abnormality of cochlea (HP:0000375)1.85076856
156Bell-shaped thorax (HP:0001591)1.83732360
157Increased nuchal translucency (HP:0010880)1.83280052
158Horseshoe kidney (HP:0000085)1.83072475
159Patellar dislocation (HP:0002999)1.82869091
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82844554
161* Broad phalanges of the hand (HP:0009768)1.82574543
162* Symphalangism affecting the phalanges of the hand (HP:0009773)1.82461264
163* Broad phalanx (HP:0006009)1.81255055
164Abnormality of the line of Schwalbe (HP:0008048)1.80030815
165Aortic aneurysm (HP:0004942)1.79243487
166Absent toe (HP:0010760)1.78714077
167* Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.78417160
168Slender long bone (HP:0003100)1.78358733
169Cervical subluxation (HP:0003308)1.78230829
170Dilatation of the ascending aorta (HP:0005111)1.77115851
171* Broad finger (HP:0001500)1.76611210
172* Abnormality of the umbilical cord (HP:0010881)1.76460367
173Volvulus (HP:0002580)1.75554946
174Dislocated radial head (HP:0003083)1.75441670
175* Triphalangeal thumb (HP:0001199)1.72534942
176Abnormality of the radial head (HP:0003995)1.70722490
177Progressive external ophthalmoplegia (HP:0000590)1.70647847
178Nonimmune hydrops fetalis (HP:0001790)1.70589607
179Dysphonia (HP:0001618)1.66766420
180Urethral obstruction (HP:0000796)1.65550004
181Exotropia (HP:0000577)1.65257697
182Sensory axonal neuropathy (HP:0003390)1.64834234
183* Radioulnar synostosis (HP:0002974)1.62011850
184Abnormality of the astrocytes (HP:0100707)1.60264046
185Astrocytoma (HP:0009592)1.60264046
186* Abnormality of the distal phalanx of the thumb (HP:0009617)1.60095825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.11503335
2NME24.29913236
3LATS24.05234183
4BUB13.96851108
5DDR23.87135749
6PDGFRA3.76071285
7MAP3K103.24945033
8MKNK13.01280146
9TRIB32.92217977
10SMG12.69525222
11IRAK32.58036064
12PKN22.56387940
13EPHB22.53259557
14TTN2.53066609
15PTK62.35197199
16MKNK22.20622560
17FGFR22.03540127
18CHEK21.93048622
19RIPK11.91797037
20PLK41.91196942
21ERBB31.88219125
22STK161.87987562
23STK31.87599046
24STK38L1.87571353
25VRK21.83911875
26PAK41.78455705
27KDR1.73134743
28FER1.73014667
29CDC71.57259280
30ATR1.54916080
31PNCK1.51974454
32TRIM281.51483463
33FGFR11.49481863
34PAK21.48751810
35CAMK1G1.47703865
36EEF2K1.41865026
37CDK61.35438262
38CDK121.29317460
39TGFBR11.28664823
40STK41.27053575
41AURKA1.26619665
42ERBB21.26023298
43PASK1.23895696
44PRPF4B1.23132220
45PTK21.18706929
46PLK11.18655417
47PDGFRB1.14716403
48BRSK11.13832388
49MET1.13654878
50IRAK21.13199491
51CAMK1D1.11880549
52CSNK1A1L1.10232191
53LRRK21.09232943
54EIF2AK11.08282165
55BMX1.05949917
56ICK1.05725187
57PRKD31.03588556
58CDK31.00885705
59AKT21.00659460
60TAOK21.00622404
61NEK91.00082067
62MTOR0.99919320
63BRAF0.98631606
64FRK0.95689307
65TYRO30.93101318
66CSNK1G10.92120366
67RPS6KB20.89065563
68PAK30.88335926
69MAP3K80.88099402
70ATM0.87072241
71CSNK1G30.86266945
72NME10.84087408
73ALK0.81956795
74SRPK10.80830473
75KSR10.80814454
76PBK0.77872718
77TESK10.77368792
78CDK80.76039382
79RPS6KA50.75230287
80TAF10.74803177
81TTK0.73900889
82CDK70.73533965
83PLK30.71493824
84RPS6KL10.68729336
85RPS6KC10.68729336
86PIM10.68680250
87CSNK1G20.68593739
88MAP2K30.64784274
89VRK10.64389699
90RPS6KA60.64182460
91BCKDK0.63064116
92CDK11A0.61964528
93LIMK10.61631197
94MELK0.59371442
95RPS6KA40.59117493
96NEK20.58626501
97SCYL20.56131961
98DYRK1B0.54937698
99TLK10.53657416
100CLK10.52703784
101CSNK2A10.52366340
102CSNK2A20.52237399
103CDK40.49939527
104CDK180.49500959
105ILK0.47894146
106STK380.47674737
107PRKDC0.47279922
108SIK10.46958727
109BRD40.46665539
110TESK20.46589124
111AKT30.46395972
112EPHA30.46269149
113STK100.45358724
114CAMK40.45251504
115PIM20.44686066
116PLK20.43997361
117MAPK110.43355965
118RPS6KA10.43221751
119ARAF0.43060200
120IRAK40.42982870
121MAP2K20.41464384
122ADRBK10.41218559
123CSNK1E0.41159191
124SRC0.39259650
125PRKD10.38722947
126ERN10.38198175
127FLT30.38008405
128TGFBR20.38004914
129CDK20.37509309
130WEE10.36992128
131ABL20.35206960
132CDK10.35022724
133MAPK10.34911130
134PAK10.34197228
135MAPK90.33497089
136KSR20.32745359
137PIK3CA0.32688484
138DMPK0.32453529
139ROCK20.32377881
140RAF10.32280678
141ROCK10.32061419
142AKT10.31595876
143CHEK10.31595679
144MAPK140.31311427
145RET0.31136815
146CDK140.31014634
147DYRK30.29875804
148AURKB0.29874173
149NEK10.29819362
150GSK3A0.29765038
151CDK90.28497129
152MAPK80.27885613
153CDK150.27106773

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.48423824
2Basal cell carcinoma_Homo sapiens_hsa052174.32283711
3Hedgehog signaling pathway_Homo sapiens_hsa043403.52469273
4Hippo signaling pathway_Homo sapiens_hsa043903.51529610
5Sulfur relay system_Homo sapiens_hsa041223.49103356
6One carbon pool by folate_Homo sapiens_hsa006703.04493991
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.02825668
8Base excision repair_Homo sapiens_hsa034102.97815908
9Mismatch repair_Homo sapiens_hsa034302.88129267
10RNA polymerase_Homo sapiens_hsa030202.87381835
11TGF-beta signaling pathway_Homo sapiens_hsa043502.86122544
12Proteoglycans in cancer_Homo sapiens_hsa052052.74057260
13Adherens junction_Homo sapiens_hsa045202.40694208
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34034179
15Pyrimidine metabolism_Homo sapiens_hsa002402.33560133
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.30672406
17Wnt signaling pathway_Homo sapiens_hsa043102.21017390
18MicroRNAs in cancer_Homo sapiens_hsa052062.15703325
19Nucleotide excision repair_Homo sapiens_hsa034202.13069580
20Homologous recombination_Homo sapiens_hsa034402.09366208
21Chronic myeloid leukemia_Homo sapiens_hsa052202.04291240
22ECM-receptor interaction_Homo sapiens_hsa045122.01618790
23Focal adhesion_Homo sapiens_hsa045101.99352772
24Cell cycle_Homo sapiens_hsa041101.86240430
25Melanogenesis_Homo sapiens_hsa049161.84498091
26Axon guidance_Homo sapiens_hsa043601.82563293
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.81762351
28Bladder cancer_Homo sapiens_hsa052191.81017873
29Colorectal cancer_Homo sapiens_hsa052101.68008244
30Non-homologous end-joining_Homo sapiens_hsa034501.65603412
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55435035
32Prostate cancer_Homo sapiens_hsa052151.53571528
33Small cell lung cancer_Homo sapiens_hsa052221.52529509
34Thyroid cancer_Homo sapiens_hsa052161.51405824
35HTLV-I infection_Homo sapiens_hsa051661.50609525
36Spliceosome_Homo sapiens_hsa030401.49491356
37Fanconi anemia pathway_Homo sapiens_hsa034601.49441801
38Folate biosynthesis_Homo sapiens_hsa007901.48584673
39Oxidative phosphorylation_Homo sapiens_hsa001901.48365667
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48002773
41Tight junction_Homo sapiens_hsa045301.46815968
42Endometrial cancer_Homo sapiens_hsa052131.46645820
43Pathways in cancer_Homo sapiens_hsa052001.44115588
44Parkinsons disease_Homo sapiens_hsa050121.42687189
45RNA degradation_Homo sapiens_hsa030181.39634152
46Huntingtons disease_Homo sapiens_hsa050161.38944468
47Melanoma_Homo sapiens_hsa052181.34461252
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32946709
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32542860
50Purine metabolism_Homo sapiens_hsa002301.31047621
51Basal transcription factors_Homo sapiens_hsa030221.29327829
52Vitamin B6 metabolism_Homo sapiens_hsa007501.29169941
53Glioma_Homo sapiens_hsa052141.27410871
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.26320293
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21706795
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20171891
57mRNA surveillance pathway_Homo sapiens_hsa030151.17791508
58Pancreatic cancer_Homo sapiens_hsa052121.12085323
59p53 signaling pathway_Homo sapiens_hsa041151.11348665
60Viral myocarditis_Homo sapiens_hsa054161.11057220
61Amoebiasis_Homo sapiens_hsa051461.10625885
62Non-small cell lung cancer_Homo sapiens_hsa052231.08944989
63Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08615499
64Rap1 signaling pathway_Homo sapiens_hsa040151.06993781
65Gap junction_Homo sapiens_hsa045401.05005969
66Biosynthesis of amino acids_Homo sapiens_hsa012301.03610407
67RNA transport_Homo sapiens_hsa030131.03344472
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02024686
69PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01823769
70Proteasome_Homo sapiens_hsa030500.99341506
71Oocyte meiosis_Homo sapiens_hsa041140.96287383
72Protein digestion and absorption_Homo sapiens_hsa049740.95503493
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.95387972
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95034591
75Dilated cardiomyopathy_Homo sapiens_hsa054140.94134341
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94071736
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92249046
78Viral carcinogenesis_Homo sapiens_hsa052030.90719362
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89930089
80Notch signaling pathway_Homo sapiens_hsa043300.88791393
81Estrogen signaling pathway_Homo sapiens_hsa049150.87462031
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85369612
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.84929947
84Renal cell carcinoma_Homo sapiens_hsa052110.82701118
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.80441487
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79951824
87Lysine degradation_Homo sapiens_hsa003100.78575409
88Alzheimers disease_Homo sapiens_hsa050100.77485438
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75885162
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74015543
91Hepatitis B_Homo sapiens_hsa051610.73464411
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70076522
93Arginine and proline metabolism_Homo sapiens_hsa003300.69570133
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69467692
95ErbB signaling pathway_Homo sapiens_hsa040120.68896890
96Pyruvate metabolism_Homo sapiens_hsa006200.67255978
97Shigellosis_Homo sapiens_hsa051310.66437686
98mTOR signaling pathway_Homo sapiens_hsa041500.64778507
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.64496602
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64432610
101Thyroid hormone synthesis_Homo sapiens_hsa049180.63325052
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61727575
103VEGF signaling pathway_Homo sapiens_hsa043700.61563902
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59780701
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58207900
106Malaria_Homo sapiens_hsa051440.57539434
107Platelet activation_Homo sapiens_hsa046110.56847498
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56082186
109Dorso-ventral axis formation_Homo sapiens_hsa043200.54680703
110FoxO signaling pathway_Homo sapiens_hsa040680.53807449
111GnRH signaling pathway_Homo sapiens_hsa049120.52015708
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.51869126
113Epstein-Barr virus infection_Homo sapiens_hsa051690.50734572
114Systemic lupus erythematosus_Homo sapiens_hsa053220.50644458
115Alcoholism_Homo sapiens_hsa050340.49523580
116MAPK signaling pathway_Homo sapiens_hsa040100.45671958
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45559192
118N-Glycan biosynthesis_Homo sapiens_hsa005100.44574786
119Prion diseases_Homo sapiens_hsa050200.43993447
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.43964419
121Sulfur metabolism_Homo sapiens_hsa009200.42930241
122Vibrio cholerae infection_Homo sapiens_hsa051100.42762001
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41288527
124Ras signaling pathway_Homo sapiens_hsa040140.40771945
125Carbon metabolism_Homo sapiens_hsa012000.39706332
126Herpes simplex infection_Homo sapiens_hsa051680.36438687
127Choline metabolism in cancer_Homo sapiens_hsa052310.35905418
128Toxoplasmosis_Homo sapiens_hsa051450.35542106
129TNF signaling pathway_Homo sapiens_hsa046680.34105360
130Endocytosis_Homo sapiens_hsa041440.33813700
131Selenocompound metabolism_Homo sapiens_hsa004500.33304192
132Metabolic pathways_Homo sapiens_hsa011000.33134295
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33016545
134AMPK signaling pathway_Homo sapiens_hsa041520.32773201
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32687121
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32337241
137Renin-angiotensin system_Homo sapiens_hsa046140.30984257
138HIF-1 signaling pathway_Homo sapiens_hsa040660.30340234
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29737440
140Fatty acid elongation_Homo sapiens_hsa000620.28986924
141Cocaine addiction_Homo sapiens_hsa050300.28340952
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27263836
143DNA replication_Homo sapiens_hsa030300.26880087
144Glucagon signaling pathway_Homo sapiens_hsa049220.26380378
145Apoptosis_Homo sapiens_hsa042100.23483293
146Pentose phosphate pathway_Homo sapiens_hsa000300.23169551
147Phenylalanine metabolism_Homo sapiens_hsa003600.20192049
148Insulin signaling pathway_Homo sapiens_hsa049100.20182288
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20155519
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20069517
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19411237

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