HOXD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cranial nerve structural organization (GO:0021604)5.06442369
2cranial nerve morphogenesis (GO:0021602)5.01876581
3short-term memory (GO:0007614)4.96722977
4receptor recycling (GO:0001881)4.86538000
5proximal/distal pattern formation (GO:0009954)4.80880622
6facial nerve structural organization (GO:0021612)4.79151000
7polarized epithelial cell differentiation (GO:0030859)4.74695797
8outer ear morphogenesis (GO:0042473)4.58357879
9pattern specification involved in kidney development (GO:0061004)4.56820672
10regulation of secondary heart field cardioblast proliferation (GO:0003266)4.37596654
11regulation of cardioblast proliferation (GO:0003264)4.37596654
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.33902226
13collecting duct development (GO:0072044)4.20843646
14skeletal muscle organ development (GO:0060538)4.20417063
15negative regulation of axon extension involved in axon guidance (GO:0048843)4.20302273
16enteric nervous system development (GO:0048484)4.13099314
17negative regulation of axon guidance (GO:1902668)4.07507386
18* thyroid gland development (GO:0030878)4.04918503
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.02289282
20axon extension involved in axon guidance (GO:0048846)4.02289282
21diaphragm development (GO:0060539)3.99386618
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.97592387
23axon ensheathment in central nervous system (GO:0032291)3.95443082
24central nervous system myelination (GO:0022010)3.95443082
25lymph vessel development (GO:0001945)3.94462735
26anatomical structure arrangement (GO:0048532)3.92696522
27cell migration in hindbrain (GO:0021535)3.91440643
28metanephric nephron tubule development (GO:0072234)3.91174494
29metanephric tubule development (GO:0072170)3.91174494
30* embryonic skeletal system morphogenesis (GO:0048704)3.91164986
31kidney mesenchyme development (GO:0072074)3.90080377
32respiratory tube development (GO:0030323)3.89520857
33positive regulation of gastrulation (GO:2000543)3.83268414
34metanephric mesenchyme development (GO:0072075)3.82870512
35bone trabecula formation (GO:0060346)3.82349596
36cochlea morphogenesis (GO:0090103)3.80098466
37regulation of heart morphogenesis (GO:2000826)3.77707670
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.65569363
39cell migration involved in heart development (GO:0060973)3.64985874
40forelimb morphogenesis (GO:0035136)3.63226041
41embryonic forelimb morphogenesis (GO:0035115)3.59187975
42hindlimb morphogenesis (GO:0035137)3.57758428
43pyrimidine nucleobase catabolic process (GO:0006208)3.52770739
44mesenchymal cell proliferation (GO:0010463)3.50877975
45lung-associated mesenchyme development (GO:0060484)3.50785625
46mesenchymal cell differentiation involved in renal system development (GO:2001012)3.50403160
47mesenchymal cell differentiation involved in kidney development (GO:0072161)3.50403160
48negative regulation of catenin import into nucleus (GO:0035414)3.50374570
49embryonic skeletal joint morphogenesis (GO:0060272)3.50086914
50metanephric nephron epithelium development (GO:0072243)3.48338934
51myoblast migration (GO:0051451)3.44724576
52regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.44575356
53lateral sprouting from an epithelium (GO:0060601)3.43326669
54motor neuron axon guidance (GO:0008045)3.40987066
55paraxial mesoderm development (GO:0048339)3.39131060
56establishment of monopolar cell polarity (GO:0061162)3.38557982
57establishment or maintenance of monopolar cell polarity (GO:0061339)3.38557982
58outflow tract septum morphogenesis (GO:0003148)3.37200870
59* skeletal system morphogenesis (GO:0048705)3.35303360
60establishment of apical/basal cell polarity (GO:0035089)3.33055294
61artery development (GO:0060840)3.31620114
62cartilage morphogenesis (GO:0060536)3.29269154
63regulation of organ formation (GO:0003156)3.27474930
64body morphogenesis (GO:0010171)3.27293003
65mesonephros development (GO:0001823)3.26939376
66metanephric epithelium development (GO:0072207)3.26360029
67apical protein localization (GO:0045176)3.23510957
68generation of neurons (GO:0048699)3.17903394
69positive regulation of chondrocyte differentiation (GO:0032332)3.16732778
70nephron tubule formation (GO:0072079)3.13091216
71neuron fate specification (GO:0048665)3.12825700
72hippo signaling (GO:0035329)3.12365576
73endocardial cushion development (GO:0003197)3.10955078
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.10380690
75regulation of mesenchymal cell apoptotic process (GO:2001053)3.10283683
76regulation of axon guidance (GO:1902667)3.10250597
77embryonic hindlimb morphogenesis (GO:0035116)3.09724436
78embryonic skeletal system development (GO:0048706)3.07877148
79regulation of cardioblast differentiation (GO:0051890)3.07395375
80establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.06131994
81chondrocyte proliferation (GO:0035988)3.06012778
82negative regulation of kidney development (GO:0090185)3.05515148
83regulation of axon extension involved in axon guidance (GO:0048841)3.04959957
84mesenchyme development (GO:0060485)3.03997845
85regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.03419120
86regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.03316744
87organ induction (GO:0001759)3.02120541
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.02036681
89mesenchymal-epithelial cell signaling (GO:0060638)3.01934400
90dorsal/ventral neural tube patterning (GO:0021904)3.01263694
91head development (GO:0060322)3.00905647
92negative regulation of axon extension (GO:0030517)2.98943846
93ganglion development (GO:0061548)2.98673476
94regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98040189
95myoblast fusion (GO:0007520)2.97754053
96aorta morphogenesis (GO:0035909)2.95191888
97regulation of establishment of planar polarity (GO:0090175)2.94680228
98urogenital system development (GO:0001655)2.94441023
99mesenchymal to epithelial transition (GO:0060231)2.92465568
100protein heterotrimerization (GO:0070208)2.92368261
101regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.92157804
102nephron tubule development (GO:0072080)2.88344270
103positive regulation of actin filament depolymerization (GO:0030836)2.88249230
104non-canonical Wnt signaling pathway (GO:0035567)2.87070705
105middle ear morphogenesis (GO:0042474)2.86709309
106positive regulation of cartilage development (GO:0061036)2.86383949
107* anterior/posterior pattern specification (GO:0009952)2.85823167
108muscle cell migration (GO:0014812)2.84936190
109peripheral nervous system neuron development (GO:0048935)2.84314231
110embryonic cranial skeleton morphogenesis (GO:0048701)2.83788199
111neurofilament cytoskeleton organization (GO:0060052)2.83404648
112cell differentiation involved in metanephros development (GO:0072202)2.82967963
113eyelid development in camera-type eye (GO:0061029)2.79967803
114skeletal muscle tissue development (GO:0007519)2.79950659
115establishment of planar polarity (GO:0001736)2.79550481
116establishment of tissue polarity (GO:0007164)2.79550481
117cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.79536785
118coronary vasculature morphogenesis (GO:0060977)2.79260959
119mesenchyme morphogenesis (GO:0072132)2.78502954
120* embryonic organ morphogenesis (GO:0048562)2.76470388
121embryonic limb morphogenesis (GO:0030326)2.76242238
122embryonic appendage morphogenesis (GO:0035113)2.76242238
123metanephros development (GO:0001656)2.75971422
124cell proliferation involved in metanephros development (GO:0072203)2.73585712
125pre-miRNA processing (GO:0031054)2.72978510
126asymmetric protein localization (GO:0008105)2.72698965
127regulation of NFAT protein import into nucleus (GO:0051532)2.66760082
128endocardial cushion morphogenesis (GO:0003203)2.65358618
129urinary tract smooth muscle contraction (GO:0014848)2.65255568
130neuromuscular synaptic transmission (GO:0007274)2.64827600
131positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.63871650
132negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.63662855
133dendritic spine organization (GO:0097061)2.63605420
134syncytium formation by plasma membrane fusion (GO:0000768)2.55863812
135vascular endothelial growth factor signaling pathway (GO:0038084)2.55602493
136limb morphogenesis (GO:0035108)2.51996611
137appendage morphogenesis (GO:0035107)2.51996611
138pharyngeal system development (GO:0060037)2.51736727
139collagen fibril organization (GO:0030199)2.51172395
140regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.51121663
141axon extension (GO:0048675)2.50125631
142developmental induction (GO:0031128)2.49612471
143lymphangiogenesis (GO:0001946)2.45401912
144segment specification (GO:0007379)2.45084004
145extracellular fibril organization (GO:0043206)2.44228543
146muscle cell fate commitment (GO:0042693)2.43837144
147mammary gland development (GO:0030879)2.43532570
148artery morphogenesis (GO:0048844)2.43217768
149positive regulation of protein kinase C signaling (GO:0090037)2.43003504
150regulation of apoptotic process involved in morphogenesis (GO:1902337)2.41936462
151regulation of chondrocyte differentiation (GO:0032330)2.41282359
152limb development (GO:0060173)2.41129192
153appendage development (GO:0048736)2.41129192
154positive regulation of mesonephros development (GO:0061213)2.40776053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_27304074_Chip-Seq_ESCs_Mouse3.42834925
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.41980112
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.33458231
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19631930
5* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.19466984
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.19466984
7PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.13658497
8* SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.03138041
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.96534672
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.84919718
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59910957
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59290062
13* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.58805349
14RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.53243363
15* CBX2_27304074_Chip-Seq_ESCs_Mouse2.52222103
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.50709608
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50186754
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.49799075
19* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46574463
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.46276711
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.44948145
22STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39440308
23EZH2_22144423_ChIP-Seq_EOC_Human2.39418136
24TP53_20018659_ChIP-ChIP_R1E_Mouse2.37889277
25ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36525475
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35582781
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32926235
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29237339
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.20116237
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.16236671
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11324234
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05879539
33* RING1B_27294783_Chip-Seq_NPCs_Mouse1.97227355
34* RING1B_27294783_Chip-Seq_ESCs_Mouse1.89060533
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.86717404
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85800551
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85800551
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85800551
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.76235104
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74208210
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74169011
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70830872
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70105077
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70041309
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69776699
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69172826
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65252514
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.64478645
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56301896
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54026209
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51250767
52* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48524541
53RNF2_27304074_Chip-Seq_NSC_Mouse1.46731991
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.41840178
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41453249
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.41248716
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41158168
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40604764
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.36695163
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36201649
61* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35472672
62* KDM2B_26808549_Chip-Seq_K562_Human1.33098877
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.32871688
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32313299
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30170479
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27744590
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24528678
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23944648
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22391462
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20857070
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20785459
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20398881
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.20292983
74* LXR_22292898_ChIP-Seq_THP-1_Human1.19030881
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.14130240
76CLOCK_20551151_ChIP-Seq_293T_Human1.13476432
77* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12874305
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10546145
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.10540244
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.08338391
81STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06508869
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04416143
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01746923
84SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99447918
85CTCF_27219007_Chip-Seq_Bcells_Human0.96428890
86MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.95952474
87DROSHA_22980978_ChIP-Seq_HELA_Human0.95701612
88NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95525851
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.95100155
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94644522
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.94393246
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.93804942
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93168327
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92891749
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92054043
96RACK7_27058665_Chip-Seq_MCF-7_Human0.91883283
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91824710
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.91260259
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90904529
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90610097
101CREB1_26743006_Chip-Seq_LNCaP_Human0.88391339
102AR_21572438_ChIP-Seq_LNCaP_Human0.87290917
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86846433
104PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85834000
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84364471
106ZNF274_21170338_ChIP-Seq_K562_Hela0.84100358
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83895356
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83327845
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83111336
110TP53_22127205_ChIP-Seq_IMR90_Human0.82711410
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.82132107
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82037683
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.81598286
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81567075
115ZNF263_19887448_ChIP-Seq_K562_Human0.81161848
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.79470887
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78896790
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78483372
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78196171
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77965464
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77396325
122XRN2_22483619_ChIP-Seq_HELA_Human0.77087017
123* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.76945654
124* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76869741
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76126144
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74011310
127AHR_22903824_ChIP-Seq_MCF-7_Human0.73615628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.96699063
2MP0003385_abnormal_body_wall3.19391269
3MP0000534_abnormal_ureter_morphology3.11422431
4MP0009250_abnormal_appendicular_skeleto2.94706917
5MP0005623_abnormal_meninges_morphology2.94520408
6MP0003122_maternal_imprinting2.80061716
7MP0002249_abnormal_larynx_morphology2.69333397
8MP0003942_abnormal_urinary_system2.67260451
9MP0009053_abnormal_anal_canal2.65435517
10MP0010030_abnormal_orbit_morphology2.49221428
11MP0005503_abnormal_tendon_morphology2.47484268
12MP0008438_abnormal_cutaneous_collagen2.32893877
13MP0002638_abnormal_pupillary_reflex2.27075599
14MP0003123_paternal_imprinting2.21497534
15MP0000049_abnormal_middle_ear2.16468790
16MP0003315_abnormal_perineum_morphology2.12045213
17MP0002282_abnormal_trachea_morphology2.11980872
18MP0004272_abnormal_basement_membrane2.08474805
19MP0005083_abnormal_biliary_tract2.06341546
20* MP0002932_abnormal_joint_morphology1.95547701
21MP0004233_abnormal_muscle_weight1.86150721
22MP0003938_abnormal_ear_development1.81229731
23MP0000778_abnormal_nervous_system1.80631426
24MP0003937_abnormal_limbs/digits/tail_de1.76957665
25MP0001346_abnormal_lacrimal_gland1.72425252
26MP0001502_abnormal_circadian_rhythm1.68127792
27* MP0002114_abnormal_axial_skeleton1.66613286
28MP0010386_abnormal_urinary_bladder1.61743430
29MP0003705_abnormal_hypodermis_morpholog1.61703700
30MP0003755_abnormal_palate_morphology1.61469457
31MP0000566_synostosis1.60927029
32MP0003121_genomic_imprinting1.59888199
33MP0004145_abnormal_muscle_electrophysio1.58759109
34MP0000955_abnormal_spinal_cord1.58465985
35MP0002822_catalepsy1.58317810
36MP0003941_abnormal_skin_development1.56098764
37MP0002160_abnormal_reproductive_system1.50102727
38MP0005508_abnormal_skeleton_morphology1.47962361
39MP0002938_white_spotting1.44415683
40MP0000762_abnormal_tongue_morphology1.43822196
41MP0000428_abnormal_craniofacial_morphol1.43621002
42MP0003115_abnormal_respiratory_system1.43024220
43MP0005409_darkened_coat_color1.39436615
44MP0001348_abnormal_lacrimal_gland1.38559788
45MP0002184_abnormal_innervation1.38269241
46MP0003935_abnormal_craniofacial_develop1.36548511
47MP0009672_abnormal_birth_weight1.35990097
48MP0005367_renal/urinary_system_phenotyp1.33566598
49MP0000516_abnormal_urinary_system1.33566598
50MP0002751_abnormal_autonomic_nervous1.33438605
51* MP0002116_abnormal_craniofacial_bone1.32201910
52MP0004858_abnormal_nervous_system1.30103244
53MP0002127_abnormal_cardiovascular_syste1.29405866
54MP0000681_abnormal_thyroid_gland1.28185784
55MP0003861_abnormal_nervous_system1.27409622
56MP0002108_abnormal_muscle_morphology1.27337915
57MP0004270_analgesia1.23603059
58MP0004197_abnormal_fetal_growth/weight/1.21444739
59MP0002653_abnormal_ependyma_morphology1.21269678
60MP0000538_abnormal_urinary_bladder1.20931229
61MP0005670_abnormal_white_adipose1.20381339
62MP0001299_abnormal_eye_distance/1.19385943
63MP0000467_abnormal_esophagus_morphology1.19314201
64MP0005187_abnormal_penis_morphology1.18723862
65MP0001340_abnormal_eyelid_morphology1.18714543
66MP0002177_abnormal_outer_ear1.15695485
67MP0001958_emphysema1.15657865
68MP0000462_abnormal_digestive_system1.15265343
69MP0005275_abnormal_skin_tensile1.14129189
70MP0002111_abnormal_tail_morphology1.13876773
71MP0000749_muscle_degeneration1.13847030
72MP0003119_abnormal_digestive_system1.12424118
73MP0009780_abnormal_chondrocyte_physiolo1.11859331
74MP0001188_hyperpigmentation1.08978520
75MP0005084_abnormal_gallbladder_morpholo1.07431680
76MP0002233_abnormal_nose_morphology1.07071769
77MP0002081_perinatal_lethality1.05885266
78MP0002896_abnormal_bone_mineralization1.05242121
79MP0000678_abnormal_parathyroid_gland1.04483767
80MP0005257_abnormal_intraocular_pressure1.04419962
81MP0002109_abnormal_limb_morphology1.03678003
82MP0009703_decreased_birth_body1.03234712
83MP0005171_absent_coat_pigmentation1.02934099
84* MP0002752_abnormal_somatic_nervous1.02895861
85MP0004084_abnormal_cardiac_muscle1.02521480
86MP0000003_abnormal_adipose_tissue1.01162530
87MP0006138_congestive_heart_failure1.00725497
88MP0008961_abnormal_basal_metabolism1.00331359
89MP0001879_abnormal_lymphatic_vessel0.99737193
90MP0004142_abnormal_muscle_tone0.99519377
91MP0003136_yellow_coat_color0.98091659
92MP0003279_aneurysm0.97978913
93MP0001661_extended_life_span0.97099470
94MP0000631_abnormal_neuroendocrine_gland0.96911117
95MP0000751_myopathy0.96712916
96MP0003011_delayed_dark_adaptation0.94293903
97MP0000733_abnormal_muscle_development0.93527438
98MP0000163_abnormal_cartilage_morphology0.92894180
99MP0001270_distended_abdomen0.92005307
100MP0005595_abnormal_vascular_smooth0.91730856
101MP0006054_spinal_hemorrhage0.91678445
102MP0004885_abnormal_endolymph0.91250341
103MP0002269_muscular_atrophy0.90420481
104MP0004087_abnormal_muscle_fiber0.90281819
105MP0002882_abnormal_neuron_morphology0.89935059
106MP0008932_abnormal_embryonic_tissue0.89835674
107MP0009384_cardiac_valve_regurgitation0.89816309
108MP0005369_muscle_phenotype0.89721374
109MP0002085_abnormal_embryonic_tissue0.89026010
110MP0010368_abnormal_lymphatic_system0.88824701
111MP0004134_abnormal_chest_morphology0.87650569
112MP0002115_abnormal_skeleton_extremities0.87323068
113MP0004036_abnormal_muscle_relaxation0.85798375
114MP0000432_abnormal_head_morphology0.85443600
115MP0002877_abnormal_melanocyte_morpholog0.84721025
116MP0002928_abnormal_bile_duct0.84257901
117MP0002102_abnormal_ear_morphology0.81485619
118MP0002734_abnormal_mechanical_nocicepti0.81333193
119MP0001664_abnormal_digestion0.81101681
120MP0002152_abnormal_brain_morphology0.80192393
121MP0003646_muscle_fatigue0.79966254
122MP0002697_abnormal_eye_size0.78787458
123MP0000759_abnormal_skeletal_muscle0.78111037
124MP0000767_abnormal_smooth_muscle0.77671039
125MP0003943_abnormal_hepatobiliary_system0.75294384
126MP0002089_abnormal_postnatal_growth/wei0.74962483
127MP0002084_abnormal_developmental_patter0.74917730
128MP0008789_abnormal_olfactory_epithelium0.74175004
129MP0001177_atelectasis0.73425849
130MP0002092_abnormal_eye_morphology0.73029993
131MP0005375_adipose_tissue_phenotype0.72825198
132MP0002733_abnormal_thermal_nociception0.72732343
133MP0002113_abnormal_skeleton_development0.72424509
134MP0001286_abnormal_eye_development0.72134403
135MP0005197_abnormal_uvea_morphology0.70062600
136MP0003879_abnormal_hair_cell0.70018232
137MP0005620_abnormal_muscle_contractility0.69999003
138MP0000613_abnormal_salivary_gland0.68943999
139MP0003634_abnormal_glial_cell0.68862183
140MP0003566_abnormal_cell_adhesion0.67007897

Predicted human phenotypes

RankGene SetZ-score
1Bicornuate uterus (HP:0000813)4.38478004
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.10907128
3Short 4th metacarpal (HP:0010044)4.10907128
4Septate vagina (HP:0001153)4.02340926
5Aplasia/Hypoplasia of the sacrum (HP:0008517)3.63216281
6Renal duplication (HP:0000075)3.61789093
7Concave nail (HP:0001598)3.46266605
8Abnormality of the 4th metacarpal (HP:0010012)3.41836638
9Abnormality of the phalanges of the hallux (HP:0010057)3.27577794
10Spinal rigidity (HP:0003306)3.24175012
11Aortic dissection (HP:0002647)3.08695745
12Shallow orbits (HP:0000586)3.05478177
13Broad face (HP:0000283)2.94839204
14Lip pit (HP:0100267)2.94344113
15Midline defect of the nose (HP:0004122)2.90273916
16Buphthalmos (HP:0000557)2.87751348
17Premature rupture of membranes (HP:0001788)2.83005257
18Aortic aneurysm (HP:0004942)2.76927642
19Bifid scrotum (HP:0000048)2.67376873
20Coronal craniosynostosis (HP:0004440)2.67364351
21Protrusio acetabuli (HP:0003179)2.64708303
22Hand muscle atrophy (HP:0009130)2.56641141
23Calcaneovalgus deformity (HP:0001848)2.56028164
24Distal upper limb amyotrophy (HP:0007149)2.43526291
25Upper limb amyotrophy (HP:0009129)2.43526291
26Arnold-Chiari malformation (HP:0002308)2.43311331
27Cerebral aneurysm (HP:0004944)2.39920852
28Ulnar bowing (HP:0003031)2.38853154
29Genu recurvatum (HP:0002816)2.37656021
30Neoplasm of the heart (HP:0100544)2.35669700
31Bladder diverticulum (HP:0000015)2.33531676
32Abnormality of the distal phalanges of the toes (HP:0010182)2.33516137
33Broad metatarsal (HP:0001783)2.33290503
34Cutaneous finger syndactyly (HP:0010554)2.33036607
35Wide anterior fontanel (HP:0000260)2.32486240
36Ankle contracture (HP:0006466)2.31471686
37Generalized hypotonia (HP:0001290)2.30728995
38Overriding aorta (HP:0002623)2.30091600
39Chin dimple (HP:0010751)2.28210411
40Deformed tarsal bones (HP:0008119)2.27919280
41Germ cell neoplasia (HP:0100728)2.24038918
42Rectal fistula (HP:0100590)2.23848542
43Rectovaginal fistula (HP:0000143)2.23848542
44Down-sloping shoulders (HP:0200021)2.23728032
45Facial shape deformation (HP:0011334)2.21558182
46Potter facies (HP:0002009)2.21558182
47Hypoventilation (HP:0002791)2.19872988
48Myelomeningocele (HP:0002475)2.19701100
49Alacrima (HP:0000522)2.19380835
50Elbow flexion contracture (HP:0002987)2.19128592
51Shawl scrotum (HP:0000049)2.18723201
52Bifid tongue (HP:0010297)2.16104678
53Periauricular skin pits (HP:0100277)2.15374919
54Preauricular pit (HP:0004467)2.15374919
55Broad toe (HP:0001837)2.14202169
56Mitral valve prolapse (HP:0001634)2.13160766
57Ankle clonus (HP:0011448)2.11731747
58Abnormality of the parietal bone (HP:0002696)2.11464752
59Hepatoblastoma (HP:0002884)2.10147881
60Atrophic scars (HP:0001075)2.08983133
61Hyperacusis (HP:0010780)2.07840469
62Soft skin (HP:0000977)2.07718427
63Lymphangioma (HP:0100764)2.06345818
64Vertebral compression fractures (HP:0002953)2.05915663
65Abnormality of the lower motor neuron (HP:0002366)2.05574109
66Anal stenosis (HP:0002025)2.02984057
67Abnormality of the fetal cardiovascular system (HP:0010948)2.00991158
68Abnormal umbilical cord blood vessels (HP:0011403)2.00991158
69Single umbilical artery (HP:0001195)2.00991158
70Wormian bones (HP:0002645)1.99366174
71Cutaneous syndactyly (HP:0012725)1.99179483
72Hyperextensible skin (HP:0000974)1.97058451
73Elfin facies (HP:0004428)1.96915708
74Horseshoe kidney (HP:0000085)1.96586301
75Hypoplasia of the iris (HP:0007676)1.95994599
76Back pain (HP:0003418)1.94278693
77Broad distal phalanx of finger (HP:0009836)1.93971834
78Abnormality of the distal phalanx of the thumb (HP:0009617)1.93574503
79Turricephaly (HP:0000262)1.93199284
80Renal hypoplasia (HP:0000089)1.92867660
81Asymmetry of the thorax (HP:0001555)1.92054334
82Vaginal fistula (HP:0004320)1.88717866
83Achilles tendon contracture (HP:0001771)1.88641608
84Deviation of the hallux (HP:0010051)1.88451813
85Intestinal fistula (HP:0100819)1.88278166
86Abnormality of the 2nd finger (HP:0004100)1.88044829
87Ulnar claw (HP:0001178)1.86773883
88Round ear (HP:0100830)1.85001511
89Renal dysplasia (HP:0000110)1.84671437
90Type 1 muscle fiber predominance (HP:0003803)1.84521367
91Renovascular hypertension (HP:0100817)1.84272494
92Vascular tortuosity (HP:0004948)1.84142739
93Vesicoureteral reflux (HP:0000076)1.83578933
94Insomnia (HP:0100785)1.82516216
95Abnormality of the vocal cords (HP:0008777)1.82254349
96Severe Myopia (HP:0011003)1.81788909
97Abnormality of the calcaneus (HP:0008364)1.81689215
98Partial agenesis of the corpus callosum (HP:0001338)1.81278105
99Ectopia lentis (HP:0001083)1.80032127
100Megalencephaly (HP:0001355)1.79839618
101Septo-optic dysplasia (HP:0100842)1.79739582
102Wrist flexion contracture (HP:0001239)1.79579563
103Aplasia/Hypoplasia of the clavicles (HP:0006710)1.78884001
104Thin bony cortex (HP:0002753)1.78787776
105Morphological abnormality of the middle ear (HP:0008609)1.78265302
106Fragile skin (HP:0001030)1.77599724
107Asymmetric growth (HP:0100555)1.76708134
108Limb-girdle muscle weakness (HP:0003325)1.76463286
109Abnormality of the Achilles tendon (HP:0005109)1.74685206
110Flat cornea (HP:0007720)1.73972174
111Bulbar palsy (HP:0001283)1.73617078
112Myokymia (HP:0002411)1.73476481
113Hypercalcemia (HP:0003072)1.73346841
114Sensory axonal neuropathy (HP:0003390)1.73034845
115Hallux valgus (HP:0001822)1.71257863
116Arterial tortuosity (HP:0005116)1.71247986
117Sacral dimple (HP:0000960)1.70858391
118Anophthalmia (HP:0000528)1.69460101
119Abnormal ventriculo-arterial connection (HP:0011563)1.69322879
120Transposition of the great arteries (HP:0001669)1.69322879
121Abnormal connection of the cardiac segments (HP:0011545)1.69322879
122Wide cranial sutures (HP:0010537)1.69008141
123Hypercortisolism (HP:0001578)1.68955893
124Abnormality of the diencephalon (HP:0010662)1.68760768
125Spinal cord lesions (HP:0100561)1.68486788
126Syringomyelia (HP:0003396)1.68486788
127Camptodactyly of toe (HP:0001836)1.68352440
128Persistence of primary teeth (HP:0006335)1.68232685
129Hypoplastic pelvis (HP:0008839)1.67992023
130Segmental peripheral demyelination/remyelination (HP:0003481)1.67686437
131Broad hallux (HP:0010055)1.67664661
132Lower limb amyotrophy (HP:0007210)1.67199338
133Mildly elevated creatine phosphokinase (HP:0008180)1.66060201
134Sprengel anomaly (HP:0000912)1.65518761
135Stridor (HP:0010307)1.64673877
136Bowel diverticulosis (HP:0005222)1.64197142
137Overgrowth (HP:0001548)1.63841484
138Abnormality of dentin (HP:0010299)1.63765907
139Lower limb asymmetry (HP:0100559)1.63737633
140Increased circulating renin level (HP:0000848)1.63118776
141High anterior hairline (HP:0009890)1.63035391
142Long toe (HP:0010511)1.62483941
143Broad thumb (HP:0011304)1.61952241
144Bronchomalacia (HP:0002780)1.61905949
145Synostosis of carpal bones (HP:0005048)1.61686615
146Increased variability in muscle fiber diameter (HP:0003557)1.61555308
147Hypercalciuria (HP:0002150)1.60681325
148Adducted thumb (HP:0001181)1.59677645
149Onion bulb formation (HP:0003383)1.58982039
150Abnormality of the parathyroid morphology (HP:0011766)1.58506098
151Atresia of the external auditory canal (HP:0000413)1.58243863
152Follicular hyperkeratosis (HP:0007502)1.57990359
153Disproportionate tall stature (HP:0001519)1.57730678
154Hypoplastic left heart (HP:0004383)1.57570553
155Short middle phalanx of the 5th finger (HP:0004220)1.57359029
156Congenital glaucoma (HP:0001087)1.57357335
157Tubular atrophy (HP:0000092)1.57212592
158Short clavicles (HP:0000894)1.56748004
159Abnormality of the umbilical cord (HP:0010881)1.56721438
160Generalized amyotrophy (HP:0003700)1.56636459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.58213524
2LIMK14.45818843
3EPHB23.44864523
4TESK22.75646456
5NME12.72588756
6TESK12.62261077
7WNK42.61980715
8STK392.51609844
9LATS22.45130065
10CDK122.29253061
11MARK11.99533082
12OXSR11.91815276
13WNK11.88064315
14CASK1.82872026
15ICK1.79004287
16PAK21.77279335
17NME21.76674790
18TIE11.75631237
19CDK191.71468166
20STK381.69853561
21MKNK21.69801836
22PDGFRA1.66591902
23WNK31.65607356
24FER1.64880848
25MKNK11.64183558
26MET1.48929562
27NTRK11.47630230
28CSNK1A1L1.46835279
29MYLK1.41407018
30UHMK11.40692940
31TRIB31.40549576
32CAMK1D1.39267628
33ALK1.35199327
34PKN11.32515527
35ROCK21.31158669
36DYRK21.28792823
37LATS11.25451538
38MARK21.24906610
39CSNK1G31.21114603
40PINK11.19061212
41MAP3K101.18222919
42BCR1.16325932
43ILK1.12860072
44PTK61.11394763
45PAK61.09356803
46PTK21.08633545
47STK38L1.05873025
48RIPK11.05641107
49TRPM71.05410812
50DDR21.03505013
51FGFR21.01250589
52ERBB30.99384567
53TTN0.98388022
54ERBB20.96508731
55PIK3CG0.96227166
56CSNK1G10.94450987
57PHKG10.94273331
58PHKG20.94273331
59DAPK30.93315226
60PAK30.88283788
61MOS0.86996451
62MINK10.86899619
63EEF2K0.86746913
64LMTK20.86138612
65CDK140.83004418
66CSNK1G20.82956016
67OBSCN0.82192455
68PNCK0.82142315
69CDK70.81770850
70AKT20.80169133
71NEK20.80101486
72RPS6KL10.79844180
73RPS6KC10.79844180
74NTRK20.79027693
75ROCK10.78608728
76PRPF4B0.76594948
77CSNK1E0.76278189
78RET0.74275763
79DYRK30.73959053
80MTOR0.71718855
81CAMK1G0.70502510
82DMPK0.70410983
83ERBB40.70333934
84PRKCI0.70084029
85PRKD10.70058833
86SRPK10.69915332
87PLK40.68129784
88PAK10.66872758
89RPS6KA60.66167633
90CAMK40.63357083
91DYRK1B0.63174258
92MAPK130.62510760
93CDK150.61613753
94BMX0.61522538
95AKT30.61075934
96MAP3K60.61072802
97EPHA20.60997233
98PRKAA10.59943389
99FGFR10.59328349
100PRKCZ0.58998595
101CDK11A0.58964966
102SGK30.58058068
103MAP2K20.57262461
104CAMK2B0.57221954
105CDK180.57196942
106ADRBK10.56800987
107RPS6KA20.56417064
108PRKD20.56128071
109CAMK2G0.54168137
110KSR10.53323724
111CLK10.52443357
112EPHB10.51902938
113CDK80.51359625
114ABL20.51121515
115PDGFRB0.51008265
116SGK20.50885432
117MAP3K70.49789774
118BRSK10.49530314
119TSSK60.49275321
120PDPK10.48395086
121TGFBR10.48024014
122CDK30.47842050
123SRC0.47424697
124PRKD30.46959625
125NEK90.46947203
126BRD40.46942358
127SGK4940.46912734
128SGK2230.46912734
129TYRO30.46846106
130CAMKK10.46804976
131MST1R0.46565232
132ARAF0.45272017
133TAOK20.44813273
134PIM20.44294411
135PKN20.43908798
136PRKCH0.43143363
137CDK50.42052952
138LRRK20.41991228
139CDC42BPA0.41657289
140PTK2B0.41016092
141PRKAA20.40737667
142PAK40.40486732
143CHEK10.40418908
144KDR0.40136385
145PRKCG0.39671112
146IRAK20.36618470
147AURKA0.35114208
148CAMK2D0.34991136
149EIF2AK10.34266921
150GSK3A0.34237162

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.76174559
2Hedgehog signaling pathway_Homo sapiens_hsa043403.44981248
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.43103220
4Basal cell carcinoma_Homo sapiens_hsa052173.24736402
5Axon guidance_Homo sapiens_hsa043602.93972088
6Steroid biosynthesis_Homo sapiens_hsa001002.52606412
7Hippo signaling pathway_Homo sapiens_hsa043902.43581544
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.24707469
9Tight junction_Homo sapiens_hsa045301.99347266
10Melanogenesis_Homo sapiens_hsa049161.91115192
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81468568
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79554020
13Wnt signaling pathway_Homo sapiens_hsa043101.63824209
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.61945045
15ECM-receptor interaction_Homo sapiens_hsa045121.57680312
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52508221
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51772990
18Proteoglycans in cancer_Homo sapiens_hsa052051.48254636
19Fatty acid biosynthesis_Homo sapiens_hsa000611.47131012
20Butanoate metabolism_Homo sapiens_hsa006501.44538354
21Fatty acid elongation_Homo sapiens_hsa000621.39932648
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29834456
23Focal adhesion_Homo sapiens_hsa045101.29788788
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27585087
25Bladder cancer_Homo sapiens_hsa052191.26077159
26Gap junction_Homo sapiens_hsa045401.24669259
27MicroRNAs in cancer_Homo sapiens_hsa052061.24496828
28Synaptic vesicle cycle_Homo sapiens_hsa047211.23615467
29Renal cell carcinoma_Homo sapiens_hsa052111.19936725
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19349232
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17724890
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17538779
33Protein digestion and absorption_Homo sapiens_hsa049741.16987578
34Lysine degradation_Homo sapiens_hsa003101.13824849
35ErbB signaling pathway_Homo sapiens_hsa040121.13057114
36Oocyte meiosis_Homo sapiens_hsa041141.12749023
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10236312
38mTOR signaling pathway_Homo sapiens_hsa041501.09290634
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08636745
40Circadian rhythm_Homo sapiens_hsa047101.05345754
41Cocaine addiction_Homo sapiens_hsa050301.05055677
42Inositol phosphate metabolism_Homo sapiens_hsa005621.04638000
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04579842
44TGF-beta signaling pathway_Homo sapiens_hsa043501.02370147
45Estrogen signaling pathway_Homo sapiens_hsa049151.02003254
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01287744
47Vibrio cholerae infection_Homo sapiens_hsa051101.01122042
48Pathways in cancer_Homo sapiens_hsa052001.00553192
49Endometrial cancer_Homo sapiens_hsa052131.00378064
50Rap1 signaling pathway_Homo sapiens_hsa040151.00064536
51Cholinergic synapse_Homo sapiens_hsa047250.99892211
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98674900
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97421378
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95968404
55mRNA surveillance pathway_Homo sapiens_hsa030150.95052502
56Glioma_Homo sapiens_hsa052140.94744408
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91381363
58Prion diseases_Homo sapiens_hsa050200.90304493
59Notch signaling pathway_Homo sapiens_hsa043300.88876431
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86337849
61Melanoma_Homo sapiens_hsa052180.86295784
62Calcium signaling pathway_Homo sapiens_hsa040200.86025769
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85303248
64Chronic myeloid leukemia_Homo sapiens_hsa052200.85207739
65Dopaminergic synapse_Homo sapiens_hsa047280.84145830
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83664649
67Long-term depression_Homo sapiens_hsa047300.83627666
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82895969
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82743364
70Sulfur relay system_Homo sapiens_hsa041220.82484990
71One carbon pool by folate_Homo sapiens_hsa006700.81043992
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.78200216
73Adherens junction_Homo sapiens_hsa045200.74260643
74Prostate cancer_Homo sapiens_hsa052150.74184310
75Thyroid cancer_Homo sapiens_hsa052160.73175093
76GnRH signaling pathway_Homo sapiens_hsa049120.70986058
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70808482
78Ras signaling pathway_Homo sapiens_hsa040140.70769752
79Spliceosome_Homo sapiens_hsa030400.69698602
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.68978656
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.68925415
82Renin secretion_Homo sapiens_hsa049240.68523895
83Endocytosis_Homo sapiens_hsa041440.67271453
84Phenylalanine metabolism_Homo sapiens_hsa003600.66826089
85Oxytocin signaling pathway_Homo sapiens_hsa049210.65324898
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62897147
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61587722
88AMPK signaling pathway_Homo sapiens_hsa041520.60866340
89Non-small cell lung cancer_Homo sapiens_hsa052230.60717026
90Gastric acid secretion_Homo sapiens_hsa049710.60312138
91Circadian entrainment_Homo sapiens_hsa047130.58746579
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58229816
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57547760
94Taste transduction_Homo sapiens_hsa047420.56992012
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56616458
96Alcoholism_Homo sapiens_hsa050340.56327120
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.55855276
98Salivary secretion_Homo sapiens_hsa049700.55781198
99HTLV-I infection_Homo sapiens_hsa051660.55272914
100Arginine and proline metabolism_Homo sapiens_hsa003300.55049041
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55009134
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.53741263
103Sphingolipid metabolism_Homo sapiens_hsa006000.52779863
104Colorectal cancer_Homo sapiens_hsa052100.51600269
105Prolactin signaling pathway_Homo sapiens_hsa049170.50844803
106Type II diabetes mellitus_Homo sapiens_hsa049300.50818782
107Acute myeloid leukemia_Homo sapiens_hsa052210.50116122
108cAMP signaling pathway_Homo sapiens_hsa040240.48731858
109Dilated cardiomyopathy_Homo sapiens_hsa054140.46796012
110Glucagon signaling pathway_Homo sapiens_hsa049220.46686751
111Tyrosine metabolism_Homo sapiens_hsa003500.46440804
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46184069
113Fatty acid metabolism_Homo sapiens_hsa012120.45859604
114Collecting duct acid secretion_Homo sapiens_hsa049660.45563853
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43977397
116Insulin signaling pathway_Homo sapiens_hsa049100.43948314
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.43636787
118Small cell lung cancer_Homo sapiens_hsa052220.43434157
119Amoebiasis_Homo sapiens_hsa051460.42569564
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42167186
121VEGF signaling pathway_Homo sapiens_hsa043700.41266481
122Thyroid hormone synthesis_Homo sapiens_hsa049180.41252558
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41073352
124Choline metabolism in cancer_Homo sapiens_hsa052310.40150806
125MAPK signaling pathway_Homo sapiens_hsa040100.39364698
126Dorso-ventral axis formation_Homo sapiens_hsa043200.36422595
127Cell cycle_Homo sapiens_hsa041100.35863925
128Pancreatic cancer_Homo sapiens_hsa052120.35433404
129Glutamatergic synapse_Homo sapiens_hsa047240.34697927
130Amphetamine addiction_Homo sapiens_hsa050310.34376032

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