HP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.81518955
2omega-hydroxylase P450 pathway (GO:0097267)9.10601603
3epoxygenase P450 pathway (GO:0019373)8.94166236
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.95614872
5L-phenylalanine catabolic process (GO:0006559)6.95614872
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.67896705
7L-phenylalanine metabolic process (GO:0006558)6.67896705
8drug metabolic process (GO:0017144)6.26819855
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26427274
10aromatic amino acid family catabolic process (GO:0009074)6.17661305
11oxidative demethylation (GO:0070989)6.04925877
12complement activation, alternative pathway (GO:0006957)5.82155118
13negative regulation of fibrinolysis (GO:0051918)5.58239852
14regulation of protein activation cascade (GO:2000257)5.57791122
15alpha-linolenic acid metabolic process (GO:0036109)5.53848909
16tryptophan catabolic process (GO:0006569)5.51932931
17indole-containing compound catabolic process (GO:0042436)5.51932931
18indolalkylamine catabolic process (GO:0046218)5.51932931
19urea cycle (GO:0000050)5.49645974
20urea metabolic process (GO:0019627)5.49645974
21glucuronate metabolic process (GO:0019585)5.48506579
22uronic acid metabolic process (GO:0006063)5.48506579
23ethanol metabolic process (GO:0006067)5.43941527
24kynurenine metabolic process (GO:0070189)5.38571113
25bile acid biosynthetic process (GO:0006699)5.38543279
26glyoxylate metabolic process (GO:0046487)5.32434528
27peptidyl-glutamic acid carboxylation (GO:0017187)5.31691144
28protein carboxylation (GO:0018214)5.31691144
29regulation of plasminogen activation (GO:0010755)5.30986109
30high-density lipoprotein particle remodeling (GO:0034375)5.30416923
31regulation of fibrinolysis (GO:0051917)5.28261160
32regulation of complement activation (GO:0030449)5.22337804
33regulation of humoral immune response (GO:0002920)5.18961580
34sulfur amino acid catabolic process (GO:0000098)5.17644220
35tryptophan metabolic process (GO:0006568)5.16851893
36positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.13327463
37disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.11538599
38killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.11538599
39regulation of triglyceride catabolic process (GO:0010896)5.06818791
40nitrogen cycle metabolic process (GO:0071941)5.04926852
41cysteine metabolic process (GO:0006534)4.93906282
42phenylpropanoid metabolic process (GO:0009698)4.87573062
43S-adenosylmethionine metabolic process (GO:0046500)4.86357843
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85495830
45negative regulation of blood coagulation (GO:0030195)4.74128851
46negative regulation of hemostasis (GO:1900047)4.74128851
47reverse cholesterol transport (GO:0043691)4.73796465
48protein-lipid complex remodeling (GO:0034368)4.72444673
49macromolecular complex remodeling (GO:0034367)4.72444673
50plasma lipoprotein particle remodeling (GO:0034369)4.72444673
51regulation of cholesterol esterification (GO:0010872)4.72251515
52bile acid metabolic process (GO:0008206)4.68231058
53plasma lipoprotein particle clearance (GO:0034381)4.68101138
54acylglycerol homeostasis (GO:0055090)4.65384577
55triglyceride homeostasis (GO:0070328)4.65384577
56serine family amino acid catabolic process (GO:0009071)4.61599444
57phospholipid efflux (GO:0033700)4.54623962
58tyrosine metabolic process (GO:0006570)4.44516962
59aromatic amino acid family metabolic process (GO:0009072)4.44348595
60homocysteine metabolic process (GO:0050667)4.42593925
61amino-acid betaine metabolic process (GO:0006577)4.32971859
62negative regulation of coagulation (GO:0050819)4.30582728
63negative regulation of wound healing (GO:0061045)4.29129145
64alpha-amino acid catabolic process (GO:1901606)4.21834663
65negative regulation of cholesterol transport (GO:0032375)4.21436982
66negative regulation of sterol transport (GO:0032372)4.21436982
67lysine metabolic process (GO:0006553)4.20069574
68lysine catabolic process (GO:0006554)4.20069574
69cholesterol efflux (GO:0033344)4.10888523
70alkaloid metabolic process (GO:0009820)4.10221901
71positive regulation of blood coagulation (GO:0030194)4.09855015
72positive regulation of hemostasis (GO:1900048)4.09855015
73fibrinolysis (GO:0042730)4.05258775
74positive regulation of lipid catabolic process (GO:0050996)3.99651549
75coenzyme catabolic process (GO:0009109)3.97283416
76positive regulation of triglyceride lipase activity (GO:0061365)3.93489268
77positive regulation of lipoprotein lipase activity (GO:0051006)3.93489268
78cellular ketone body metabolic process (GO:0046950)3.92576466
79complement activation (GO:0006956)3.91703787
80bile acid and bile salt transport (GO:0015721)3.91301607
81plasma lipoprotein particle assembly (GO:0034377)3.91258631
82* acute-phase response (GO:0006953)3.91148211
83negative regulation of complement activation (GO:0045916)3.90697839
84negative regulation of lipase activity (GO:0060192)3.90283073
85imidazole-containing compound metabolic process (GO:0052803)3.89665512
86cellular amino acid catabolic process (GO:0009063)3.89310036
87complement activation, classical pathway (GO:0006958)3.88253724
88ethanol oxidation (GO:0006069)3.85536710
89opsonization (GO:0008228)3.84995836
90indolalkylamine metabolic process (GO:0006586)3.84217643
91hormone catabolic process (GO:0042447)3.84028620
92protein activation cascade (GO:0072376)3.81821083
93flavonoid metabolic process (GO:0009812)3.81314234
94glycine metabolic process (GO:0006544)3.79939539
95response to mercury ion (GO:0046689)3.78596711
96positive regulation of coagulation (GO:0050820)3.76767177
97benzene-containing compound metabolic process (GO:0042537)3.76504202
98positive regulation of fatty acid beta-oxidation (GO:0032000)3.76086234
99amine catabolic process (GO:0009310)3.75610085
100cellular biogenic amine catabolic process (GO:0042402)3.75610085
101glutamate metabolic process (GO:0006536)3.73476021
102phospholipid homeostasis (GO:0055091)3.73232973
103arginine metabolic process (GO:0006525)3.73185459
104cytolysis (GO:0019835)3.72189511
105low-density lipoprotein particle remodeling (GO:0034374)3.71512100
106intestinal cholesterol absorption (GO:0030299)3.70777320
107regulation of apoptotic cell clearance (GO:2000425)3.68323638
108heme transport (GO:0015886)3.67897873
109blood coagulation, intrinsic pathway (GO:0007597)3.67891218
110serine family amino acid metabolic process (GO:0009069)3.67737239
111cellular glucuronidation (GO:0052695)3.67594205
112aldehyde catabolic process (GO:0046185)3.65211520
113cellular modified amino acid catabolic process (GO:0042219)3.64971576
114plasma lipoprotein particle organization (GO:0071827)3.64909371
115cholesterol homeostasis (GO:0042632)3.64123442
116regulation of acute inflammatory response (GO:0002673)3.61537183
117negative regulation of protein activation cascade (GO:2000258)3.61457843
118* acute inflammatory response (GO:0002526)3.59214098
119sterol homeostasis (GO:0055092)3.58609883
120dicarboxylic acid biosynthetic process (GO:0043650)3.56491281
121regulation of cholesterol homeostasis (GO:2000188)3.53327825
122acetyl-CoA metabolic process (GO:0006084)3.53098627
123protein-lipid complex assembly (GO:0065005)3.52861112
124fatty acid beta-oxidation (GO:0006635)3.52425235
125very-low-density lipoprotein particle assembly (GO:0034379)3.52153088
126fatty acid oxidation (GO:0019395)3.51899336
127carboxylic acid catabolic process (GO:0046395)3.51877564
128organic acid catabolic process (GO:0016054)3.51877564
129cofactor catabolic process (GO:0051187)3.49059546
130drug catabolic process (GO:0042737)3.45999788
131lipid oxidation (GO:0034440)3.45508686
132fat-soluble vitamin biosynthetic process (GO:0042362)3.45205490
133xenobiotic metabolic process (GO:0006805)3.44387916
134serine family amino acid biosynthetic process (GO:0009070)3.39781907
135positive regulation of fatty acid biosynthetic process (GO:0045723)3.38257125
136sodium-independent organic anion transport (GO:0043252)3.37309815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.79758893
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74588004
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.35776773
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.31394808
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.10914218
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.95004722
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89829597
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86415318
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74639389
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63383104
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36887430
12CLOCK_20551151_ChIP-Seq_293T_Human2.17605955
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2224955
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95244231
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83399515
16GATA1_22025678_ChIP-Seq_K562_Human1.79746147
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68829969
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58401618
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.55056945
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42229157
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34824552
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30994883
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.26512697
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.23187315
25HTT_18923047_ChIP-ChIP_STHdh_Human1.18592097
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16661916
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15857806
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13207500
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11594783
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11367654
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10186764
32RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10047821
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04643296
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98522668
35SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98352249
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96785589
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95325208
38TRIM28_21343339_ChIP-Seq_HEK293_Human0.94524217
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93771371
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86511915
41ESR2_21235772_ChIP-Seq_MCF-7_Human0.86345058
42GATA4_25053715_ChIP-Seq_YYC3_Human0.84831776
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84309226
44BCAT_22108803_ChIP-Seq_LS180_Human0.84198000
45CBP_21632823_ChIP-Seq_H3396_Human0.82344951
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80149237
47HNFA_21074721_ChIP-Seq_CACO-2_Human0.79504524
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78318725
49SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76576819
50LXR_22292898_ChIP-Seq_THP-1_Human0.76369799
51IRF1_19129219_ChIP-ChIP_H3396_Human0.74858518
52SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73333372
53PHF8_20622853_ChIP-Seq_HELA_Human0.73290841
54ZNF263_19887448_ChIP-Seq_K562_Human0.71184720
55NFE2_27457419_Chip-Seq_LIVER_Mouse0.71102075
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71046564
57NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71046564
58TP53_18474530_ChIP-ChIP_U2OS_Human0.69707456
59AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69659324
60PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69475035
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68783429
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68178652
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67987031
64SOX2_21211035_ChIP-Seq_LN229_Human0.67123533
65ESR1_21235772_ChIP-Seq_MCF-7_Human0.65794519
66NFYA_21822215_ChIP-Seq_K562_Human0.65557867
67FOXO3_23340844_ChIP-Seq_DLD1_Human0.65221841
68PIAS1_25552417_ChIP-Seq_VCAP_Human0.65056824
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65015412
70PPAR_26484153_Chip-Seq_NCI-H1993_Human0.64414084
71RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63638363
72RARA_24833708_ChIP-Seq_LIVER_Mouse0.63461447
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62760303
74GATA6_21074721_ChIP-Seq_CACO-2_Human0.62291425
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62174961
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62171090
77CEBPB_22108803_ChIP-Seq_LS180_Human0.61814817
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61015254
79GATA1_19941826_ChIP-Seq_K562_Human0.60880270
80BRD4_27068464_Chip-Seq_AML-cells_Mouse0.60149646
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59973931
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.59810197
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.59321121
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.59116962
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.57646766
86RAC3_21632823_ChIP-Seq_H3396_Human0.56795870
87CBX2_22325352_ChIP-Seq_293T-Rex_Human0.56695172
88SPI1_20517297_ChIP-Seq_HL60_Human0.56678609
89EGR1_19032775_ChIP-ChIP_M12_Human0.56633309
90GATA2_19941826_ChIP-Seq_K562_Human0.55998193
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55922462
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.55458269
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55064359
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.55020398
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.54662973
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.54164341
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.53942042
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.53360710
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52470049
100* SOX2_20726797_ChIP-Seq_SW620_Human0.52307128
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52228837
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.51469715
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51445149
104ETV1_20927104_ChIP-Seq_GIST48_Human0.51085535
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.50542138
106MYC_19829295_ChIP-Seq_ESCs_Human0.50076366
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49823057
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.49613561
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49367823
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.49319343
111ER_23166858_ChIP-Seq_MCF-7_Human0.49304155
112RACK7_27058665_Chip-Seq_MCF-7_Human0.49145467
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.48803203
114IRF8_27001747_Chip-Seq_BMDM_Mouse0.48643550
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.48551491
116AR_20517297_ChIP-Seq_VCAP_Human0.48517862
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.47654958
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47506800
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.47447103
120SMC4_20622854_ChIP-Seq_HELA_Human0.46934570
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.46495144
122CDX2_22108803_ChIP-Seq_LS180_Human0.46488936
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.46269630
124POU5F1_16518401_ChIP-PET_MESCs_Mouse0.46196256
125MYC_19915707_ChIP-ChIP_AK7_Human0.46069551
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.45918754
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.45777100
128OCT4_18555785_Chip-Seq_ESCs_Mouse0.45312569
129CSB_26484114_Chip-Seq_FIBROBLAST_Human0.45136269
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.45020285
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.45007163
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.44433112
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.43566165
134P53_21459846_ChIP-Seq_SAOS-2_Human0.43545618
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.43301700
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43139121
137CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.42716613
138TAF2_19829295_ChIP-Seq_ESCs_Human0.42493044
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.42398514
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.42398514
141GATA6_25053715_ChIP-Seq_YYC3_Human0.42311044
142BCOR_27268052_Chip-Seq_Bcells_Human0.42107452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.70309392
2MP0005360_urolithiasis6.90646871
3MP0005085_abnormal_gallbladder_physiolo5.80677610
4MP0005365_abnormal_bile_salt5.78095067
5MP0008875_abnormal_xenobiotic_pharmacok4.67692201
6MP0010329_abnormal_lipoprotein_level3.81173136
7MP0003806_abnormal_nucleotide_metabolis3.70666590
8MP0003252_abnormal_bile_duct3.45562683
9MP0009840_abnormal_foam_cell3.36073820
10MP0005083_abnormal_biliary_tract2.90263377
11MP0005332_abnormal_amino_acid2.58883281
12MP0003195_calcinosis2.48268999
13MP0001666_abnormal_nutrient_absorption2.34880385
14MP0002118_abnormal_lipid_homeostasis2.25012724
15* MP0003191_abnormal_cellular_cholesterol2.23914633
16MP0000609_abnormal_liver_physiology2.23173527
17MP0002138_abnormal_hepatobiliary_system1.93926271
18MP0004019_abnormal_vitamin_homeostasis1.92026067
19MP0005319_abnormal_enzyme/_coenzyme1.82197092
20MP0005670_abnormal_white_adipose1.73422610
21MP0001764_abnormal_homeostasis1.65982255
22MP0003705_abnormal_hypodermis_morpholog1.63421720
23MP0005584_abnormal_enzyme/coenzyme_acti1.56457650
24MP0003868_abnormal_feces_composition1.53370943
25MP0003186_abnormal_redox_activity1.47730011
26MP0003011_delayed_dark_adaptation1.44274252
27MP0009643_abnormal_urine_homeostasis1.28937241
28MP0004130_abnormal_muscle_cell1.28377169
29MP0000604_amyloidosis1.25751752
30MP0003656_abnormal_erythrocyte_physiolo1.23594779
31MP0000598_abnormal_liver_morphology1.18762861
32MP0005451_abnormal_body_composition1.18525382
33MP0010368_abnormal_lymphatic_system1.17614944
34MP0009697_abnormal_copulation1.16113732
35MP0002254_reproductive_system_inflammat1.15386511
36MP0003724_increased_susceptibility_to1.12686404
37MP0002971_abnormal_brown_adipose1.11248147
38* MP0009763_increased_sensitivity_to1.10799721
39MP0005666_abnormal_adipose_tissue1.09968458
40MP0002876_abnormal_thyroid_physiology1.07729014
41MP0005647_abnormal_sex_gland1.05026081
42* MP0009764_decreased_sensitivity_to1.04188238
43MP0008469_abnormal_protein_level1.03752627
44MP0003690_abnormal_glial_cell1.03137895
45MP0003436_decreased_susceptibility_to0.98835800
46MP0005334_abnormal_fat_pad0.96738768
47MP0002282_abnormal_trachea_morphology0.90067154
48MP0004782_abnormal_surfactant_physiolog0.89475805
49* MP0009642_abnormal_blood_homeostasis0.87901656
50MP0001915_intracranial_hemorrhage0.87173778
51MP0005636_abnormal_mineral_homeostasis0.86323656
52MP0001661_extended_life_span0.85846949
53MP0008438_abnormal_cutaneous_collagen0.85368552
54MP0002078_abnormal_glucose_homeostasis0.81460213
55MP0005376_homeostasis/metabolism_phenot0.80952625
56MP0005535_abnormal_body_temperature0.80203181
57MP0002837_dystrophic_cardiac_calcinosis0.78602969
58MP0005464_abnormal_platelet_physiology0.78149103
59MP0006036_abnormal_mitochondrial_physio0.75986224
60MP0009115_abnormal_fat_cell0.74622157
61MP0008872_abnormal_physiological_respon0.73714330
62MP0004185_abnormal_adipocyte_glucose0.73667235
63MP0005187_abnormal_penis_morphology0.72006642
64MP0002249_abnormal_larynx_morphology0.71687162
65MP0005448_abnormal_energy_balance0.70474164
66MP0003075_altered_response_to0.69673995
67MP0001756_abnormal_urination0.69298924
68MP0005408_hypopigmentation0.68977022
69* MP0009765_abnormal_xenobiotic_induced0.66466326
70MP0003879_abnormal_hair_cell0.65147971
71MP0002796_impaired_skin_barrier0.64973159
72MP0003329_amyloid_beta_deposits0.63755234
73MP0005375_adipose_tissue_phenotype0.62949957
74MP0005164_abnormal_response_to0.62313144
75MP0005167_abnormal_blood-brain_barrier0.62204182
76MP0005220_abnormal_exocrine_pancreas0.60880377
77MP0009053_abnormal_anal_canal0.58748088
78MP0002970_abnormal_white_adipose0.58489011
79MP0005058_abnormal_lysosome_morphology0.57531616
80MP0005266_abnormal_metabolism0.57419045
81MP0000249_abnormal_blood_vessel0.56738931
82MP0004883_abnormal_blood_vessel0.56562352
83MP0005084_abnormal_gallbladder_morpholo0.56329603
84MP0000639_abnormal_adrenal_gland0.55397872
85MP0005166_decreased_susceptibility_to0.55329985
86MP0002136_abnormal_kidney_physiology0.54966805
87MP0002060_abnormal_skin_morphology0.54021679
88MP0009785_altered_susceptibility_to0.53486209
89MP0005275_abnormal_skin_tensile0.51440456
90MP0005395_other_phenotype0.50918331
91MP0005023_abnormal_wound_healing0.50850358
92MP0003638_abnormal_response/metabolism_0.49473805
93MP0001881_abnormal_mammary_gland0.48325549
94MP0002168_other_aberrant_phenotype0.48034065
95MP0008873_increased_physiological_sensi0.47457766
96MP0001845_abnormal_inflammatory_respons0.46738726
97MP0001853_heart_inflammation0.45549445
98MP0001533_abnormal_skeleton_physiology0.45446567
99MP0000579_abnormal_nail_morphology0.45202028
100MP0003303_peritoneal_inflammation0.44518116
101MP0002132_abnormal_respiratory_system0.43307678
102MP0002419_abnormal_innate_immunity0.42389436
103MP0008874_decreased_physiological_sensi0.42046083
104MP0001243_abnormal_dermal_layer0.41792547
105MP0003953_abnormal_hormone_level0.40780796
106MP0000467_abnormal_esophagus_morphology0.39643606
107MP0003453_abnormal_keratinocyte_physiol0.39528019
108MP0000566_synostosis0.35725126
109MP0002332_abnormal_exercise_endurance0.34514325
110MP0001851_eye_inflammation0.32548604
111MP0005397_hematopoietic_system_phenotyp0.32244744
112MP0001545_abnormal_hematopoietic_system0.32244744
113MP0002128_abnormal_blood_circulation0.24898657
114MP0000920_abnormal_myelination0.19035268
115MP0003633_abnormal_nervous_system0.18352915
116MP0003632_abnormal_nervous_system0.18188068
117MP0005197_abnormal_uvea_morphology0.17530635

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.27660683
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.72411647
3Intrahepatic cholestasis (HP:0001406)6.50499268
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.19028109
5Prolonged partial thromboplastin time (HP:0003645)6.18305318
6Xanthomatosis (HP:0000991)6.16700852
7Complement deficiency (HP:0004431)6.12565902
8Hypobetalipoproteinemia (HP:0003563)5.76736308
9Hyperlipoproteinemia (HP:0010980)5.75161326
10Joint hemorrhage (HP:0005261)4.83390665
11Abnormality of the common coagulation pathway (HP:0010990)4.78530630
12Hypolipoproteinemia (HP:0010981)4.63317582
13Abnormality of complement system (HP:0005339)4.53627297
14Epidermoid cyst (HP:0200040)4.47407477
15Hyperammonemia (HP:0001987)4.40965851
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38644684
17Hypoalphalipoproteinemia (HP:0003233)4.36851255
18Ketosis (HP:0001946)4.05393928
19Hyperglycinemia (HP:0002154)4.03520376
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92993428
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.87103025
22Hyperglycinuria (HP:0003108)3.86939092
23Abnormality of methionine metabolism (HP:0010901)3.85590804
24Hypoglycemic coma (HP:0001325)3.82993822
25Abnormality of glycine metabolism (HP:0010895)3.76522916
26Abnormality of serine family amino acid metabolism (HP:0010894)3.76522916
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75864500
28Abnormality of the intrinsic pathway (HP:0010989)3.72531918
29Fat malabsorption (HP:0002630)3.69073438
30Hypercholesterolemia (HP:0003124)3.60630828
31Spontaneous abortion (HP:0005268)3.47645056
32Abnormality of pyrimidine metabolism (HP:0004353)3.43660227
33Systemic lupus erythematosus (HP:0002725)3.42493106
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35885363
35Abnormality of fatty-acid metabolism (HP:0004359)3.35504733
36Myocardial infarction (HP:0001658)3.24124324
37Recurrent gram-negative bacterial infections (HP:0005420)3.17189105
38Conjugated hyperbilirubinemia (HP:0002908)3.09311553
39Amyloidosis (HP:0011034)3.03853937
40Hyperbilirubinemia (HP:0002904)2.96619439
41Abnormality of nucleobase metabolism (HP:0010932)2.91169025
42Skin nodule (HP:0200036)2.86959172
43Ketoacidosis (HP:0001993)2.86506012
44Glomerulonephritis (HP:0000099)2.85183480
45Hepatocellular carcinoma (HP:0001402)2.82357808
46Steatorrhea (HP:0002570)2.80273317
47Abnormality of serum amino acid levels (HP:0003112)2.74498669
48Delayed CNS myelination (HP:0002188)2.71410386
49Abnormality of purine metabolism (HP:0004352)2.64923425
50Gingival bleeding (HP:0000225)2.63629150
51Osteomalacia (HP:0002749)2.61339232
52Metabolic acidosis (HP:0001942)2.56785461
53Purpura (HP:0000979)2.55502975
54Neonatal hypoglycemia (HP:0001998)2.54856652
55Hypochromic microcytic anemia (HP:0004840)2.50054737
56Vascular calcification (HP:0004934)2.49017424
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48930512
58Dicarboxylic aciduria (HP:0003215)2.48930512
59Rickets (HP:0002748)2.45843774
60Spastic diplegia (HP:0001264)2.41627984
61Esophageal varix (HP:0002040)2.39606491
62Mitral stenosis (HP:0001718)2.39373970
63Lethargy (HP:0001254)2.37057434
64Fair hair (HP:0002286)2.36502037
65Hypertriglyceridemia (HP:0002155)2.36175700
66Thrombophlebitis (HP:0004418)2.33401761
67Hemorrhage of the eye (HP:0011885)2.32976695
68Hypoglycemic seizures (HP:0002173)2.31624291
69Gout (HP:0001997)2.30544334
70Abnormal gallbladder morphology (HP:0012437)2.26969747
71Cardiovascular calcification (HP:0011915)2.26646257
72Pancreatitis (HP:0001733)2.24952280
73Cholelithiasis (HP:0001081)2.24457369
74Joint swelling (HP:0001386)2.21362367
75Cholecystitis (HP:0001082)2.20064863
76Abnormal gallbladder physiology (HP:0012438)2.20064863
77Menorrhagia (HP:0000132)2.19895961
78Neonatal onset (HP:0003623)2.19759984
79Nephritis (HP:0000123)2.18148208
80Acanthocytosis (HP:0001927)2.15397894
81Abnormality of iron homeostasis (HP:0011031)2.14348604
82Irritability (HP:0000737)2.13218035
83Sensorimotor neuropathy (HP:0007141)2.10744404
84Late onset (HP:0003584)2.09824053
85Cerebral edema (HP:0002181)2.08562518
86Abnormal cartilage morphology (HP:0002763)2.06777977
87Abnormality of transition element cation homeostasis (HP:0011030)2.05112267
88Vomiting (HP:0002013)2.01099536
89Brushfield spots (HP:0001088)1.99167905
90Hydroxyprolinuria (HP:0003080)1.96405206
91Abnormality of proline metabolism (HP:0010907)1.96405206
92Reduced antithrombin III activity (HP:0001976)1.95868170
93Malnutrition (HP:0004395)1.95641810
94Elevated alkaline phosphatase (HP:0003155)1.95124794
95Generalized aminoaciduria (HP:0002909)1.90628632
96Hyperphosphaturia (HP:0003109)1.87687379
97Abnormality of the gallbladder (HP:0005264)1.86416666
98Enlarged kidneys (HP:0000105)1.85991838
99Opisthotonus (HP:0002179)1.85599888
100Pulmonary embolism (HP:0002204)1.83271247
101Abnormal delivery (HP:0001787)1.82932970
102Arthropathy (HP:0003040)1.80187749
103Polycythemia (HP:0001901)1.80038980
104Hyperinsulinemic hypoglycemia (HP:0000825)1.79567880
105Abnormality of alkaline phosphatase activity (HP:0004379)1.78737890
106Elevated hepatic transaminases (HP:0002910)1.78158441
107Abnormality of vitamin metabolism (HP:0100508)1.77596296
108Gangrene (HP:0100758)1.77225341
109Nausea (HP:0002018)1.76712503
110Increased serum ferritin (HP:0003281)1.75549719
111Abnormal enzyme/coenzyme activity (HP:0012379)1.71155042
112Increased mean platelet volume (HP:0011877)1.71134534
113Glycosuria (HP:0003076)1.70569852
114Abnormality of urine glucose concentration (HP:0011016)1.70569852
115Poikilocytosis (HP:0004447)1.68394788
116Cerebral palsy (HP:0100021)1.68361107
117Hyperglycemia (HP:0003074)1.66224299
118Abnormality of the Achilles tendon (HP:0005109)1.65190461
119Epistaxis (HP:0000421)1.65007543
120Generalized hypopigmentation of hair (HP:0011358)1.64029799
121Hypophosphatemic rickets (HP:0004912)1.61785917
122Bifid scrotum (HP:0000048)1.59627950
123Increased serum pyruvate (HP:0003542)1.58196475
124Abnormal platelet volume (HP:0011876)1.55398625
125Abnormal platelet function (HP:0011869)1.51199172
126Impaired platelet aggregation (HP:0003540)1.51199172
127Atrioventricular block (HP:0001678)1.51155124
128Abnormal urine phosphate concentration (HP:0012599)1.49512359
129Abnormal biliary tract physiology (HP:0012439)1.46911338
130Bile duct proliferation (HP:0001408)1.46911338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.18282310
2ERN15.45446799
3FGFR44.22268730
4SIK14.00823340
5TRIB33.31235770
6TAOK32.47696053
7PIK3CA2.44866454
8INSRR2.28510273
9MST1R2.21134466
10ERBB42.18618152
11PKN21.93112234
12PRPF4B1.89440653
13MAP2K41.79400353
14EPHB11.76901819
15TYK21.76418154
16NTRK31.66433482
17MAPK111.61966763
18MAP2K31.59803995
19PTK61.59714610
20CAMK1D1.58299677
21NEK91.54731024
22DAPK21.54649719
23NLK1.51690185
24PIK3CG1.50141384
25TIE11.45846782
26RIPK11.43800075
27FGFR21.42580594
28FLT31.42462323
29TGFBR21.40942835
30KDR1.36020334
31LATS11.35180803
32ABL21.32924592
33JAK21.31349563
34FRK1.27687898
35JAK11.24224312
36EPHA31.24141556
37TNK21.23719825
38PRKCG1.17851694
39TBK11.16318114
40PRKAA21.15863108
41MAP3K31.15654705
42CSK1.08111680
43FGFR31.05749032
44PDK21.04514945
45GRK61.03807337
46MAP3K21.02964437
47CAMKK21.02898796
48CDK60.95261486
49PRKG10.94803812
50MET0.90221589
51MAPK40.89141555
52CAMK1G0.89093304
53IRAK30.88731023
54MAP3K110.85086064
55MAP3K70.84710712
56MAP3K140.83443950
57ERBB20.79247635
58PRKACA0.76708371
59EPHA40.74702124
60GSK3A0.71335681
61PRKACG0.70030188
62AKT30.68246710
63PRKCZ0.67823416
64PTK20.67385582
65MAP3K60.66798348
66MAPK120.66193386
67PINK10.65686313
68IKBKE0.65130611
69PDPK10.65069780
70KSR20.64836544
71PDGFRA0.61701108
72CSF1R0.61430659
73MAP2K10.57592350
74CSNK1E0.57103628
75ZAP700.56210024
76PRKACB0.54841991
77MAP2K60.53693300
78MAP3K130.53603205
79MAP3K100.53585894
80TAOK20.53428023
81PRKCB0.53112190
82EPHB20.51384466
83PRKAA10.51059202
84SGK30.50864236
85RPS6KA30.50842940
86CSNK1D0.50806729
87CAMKK10.50036380
88IGF1R0.49874677
89GRK10.48548678
90SGK4940.47001232
91SGK2230.47001232
92SCYL20.46597485
93SRC0.46457428
94BLK0.46434042
95RET0.46264653
96PRKCA0.46122991
97SGK10.45003719
98KIT0.44905548
99CAMK2G0.44658241
100BRSK20.42905099
101PDK40.41370543
102PDK30.41370543
103EGFR0.41168851
104BMX0.40768176
105CDK40.39555727
106MAP3K10.39224606
107DYRK1B0.37974187
108FER0.37862034
109MAP4K10.37265123
110CSNK2A10.37138164
111EPHA20.36324877
112PDK10.36314775
113LRRK20.35064588
114MYLK0.34867562
115JAK30.33513939
116IRAK10.33149985
117MAPK150.33045214
118MTOR0.32479899
119PRKCH0.30763542
120CSNK2A20.30753424
121ABL10.30479989
122MAPKAPK30.30300021
123MAPK30.30087005
124STK38L0.29122120
125PRKCQ0.28704002
126MAP3K50.28530996
127ITK0.27129407
128BTK0.26021365
129MAPK70.25920489
130CAMK40.24334041
131LATS20.23111284
132PKN10.21477695
133SGK20.20239089
134ICK0.20026548

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38568081
2Nitrogen metabolism_Homo sapiens_hsa009103.58201722
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20633201
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10203374
5Complement and coagulation cascades_Homo sapiens_hsa046103.07139126
6Arginine biosynthesis_Homo sapiens_hsa002203.06660621
7Tryptophan metabolism_Homo sapiens_hsa003802.60331198
8Fatty acid degradation_Homo sapiens_hsa000712.57723236
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55948762
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55233038
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46188296
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45340387
13PPAR signaling pathway_Homo sapiens_hsa033202.23081117
14Staphylococcus aureus infection_Homo sapiens_hsa051502.21576466
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11574790
16Peroxisome_Homo sapiens_hsa041462.11257232
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06487019
18Propanoate metabolism_Homo sapiens_hsa006402.04926577
19Butanoate metabolism_Homo sapiens_hsa006501.98851351
20Fatty acid metabolism_Homo sapiens_hsa012121.94382986
21Caffeine metabolism_Homo sapiens_hsa002321.89515338
22Chemical carcinogenesis_Homo sapiens_hsa052041.88127894
23Histidine metabolism_Homo sapiens_hsa003401.87334372
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84474992
25beta-Alanine metabolism_Homo sapiens_hsa004101.77578323
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.69765102
27Phenylalanine metabolism_Homo sapiens_hsa003601.65868042
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.60413750
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60265282
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60210246
31Retinol metabolism_Homo sapiens_hsa008301.56402474
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54094997
33Tyrosine metabolism_Homo sapiens_hsa003501.47407084
34Selenocompound metabolism_Homo sapiens_hsa004501.46990262
35Bile secretion_Homo sapiens_hsa049761.39638342
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39532299
37Pyruvate metabolism_Homo sapiens_hsa006201.37720839
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36987837
39Fat digestion and absorption_Homo sapiens_hsa049751.31235890
40Fatty acid elongation_Homo sapiens_hsa000621.27605905
41Starch and sucrose metabolism_Homo sapiens_hsa005001.25791621
42Sulfur metabolism_Homo sapiens_hsa009201.24385408
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.23103238
44ABC transporters_Homo sapiens_hsa020101.20690807
45Carbon metabolism_Homo sapiens_hsa012001.18558873
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17709428
47Folate biosynthesis_Homo sapiens_hsa007901.10584380
48Steroid biosynthesis_Homo sapiens_hsa001001.01989308
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97719173
50Vitamin B6 metabolism_Homo sapiens_hsa007500.94104957
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93809678
52Sulfur relay system_Homo sapiens_hsa041220.91912494
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90558100
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87780728
55Glycerolipid metabolism_Homo sapiens_hsa005610.86569109
56Arginine and proline metabolism_Homo sapiens_hsa003300.82841469
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.82243937
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.81359358
59Vitamin digestion and absorption_Homo sapiens_hsa049770.81333326
60Fatty acid biosynthesis_Homo sapiens_hsa000610.81079259
61Lysine degradation_Homo sapiens_hsa003100.73989417
62Pentose phosphate pathway_Homo sapiens_hsa000300.72499729
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71681084
64Glutathione metabolism_Homo sapiens_hsa004800.70116317
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59701219
66One carbon pool by folate_Homo sapiens_hsa006700.53005285
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52146637
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.46956059
69Prion diseases_Homo sapiens_hsa050200.44628294
70Metabolic pathways_Homo sapiens_hsa011000.40560665
71Insulin resistance_Homo sapiens_hsa049310.38152175
72Fructose and mannose metabolism_Homo sapiens_hsa000510.29491168
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27046229
74Galactose metabolism_Homo sapiens_hsa000520.23970302
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.21303502
76AMPK signaling pathway_Homo sapiens_hsa041520.19263866
77Linoleic acid metabolism_Homo sapiens_hsa005910.17445374
78Glucagon signaling pathway_Homo sapiens_hsa049220.13032340
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04984152
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01081509
81Insulin signaling pathway_Homo sapiens_hsa049100.00104592
82FoxO signaling pathway_Homo sapiens_hsa04068-0.2727521
83N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2576790
84Type II diabetes mellitus_Homo sapiens_hsa04930-0.2368585
85Sphingolipid metabolism_Homo sapiens_hsa00600-0.2332376
86Circadian rhythm_Homo sapiens_hsa04710-0.2277017
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2174692
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1610044
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1609511
90Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1557036
91Bladder cancer_Homo sapiens_hsa05219-0.1548313
92Malaria_Homo sapiens_hsa05144-0.1513605
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1495570
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1403453
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1076073
96Lysosome_Homo sapiens_hsa04142-0.1012803
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1000665
98African trypanosomiasis_Homo sapiens_hsa05143-0.0958338
99Renin-angiotensin system_Homo sapiens_hsa04614-0.0941183
100Amoebiasis_Homo sapiens_hsa05146-0.0823813
101Hepatitis C_Homo sapiens_hsa05160-0.0818044
102Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0815543
103Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0696196
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0684954
105Mineral absorption_Homo sapiens_hsa04978-0.0386917
106Serotonergic synapse_Homo sapiens_hsa04726-0.0329067
107Pertussis_Homo sapiens_hsa05133-0.0210002
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0192013
109Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0173405
110Other glycan degradation_Homo sapiens_hsa00511-0.0011781

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