HPCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.99767023
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67522424
3vocalization behavior (GO:0071625)5.67036081
4locomotory exploration behavior (GO:0035641)5.65420710
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.64977910
6regulation of glutamate receptor signaling pathway (GO:1900449)5.34418369
7sodium ion export (GO:0071436)5.32046977
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.31170429
9synaptic vesicle maturation (GO:0016188)5.16572509
10regulation of long-term neuronal synaptic plasticity (GO:0048169)5.14232234
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.05545116
12regulation of neuronal synaptic plasticity (GO:0048168)4.99681061
13synaptic vesicle exocytosis (GO:0016079)4.94766973
14protein localization to synapse (GO:0035418)4.89376955
15regulation of synapse structural plasticity (GO:0051823)4.83840881
16L-amino acid import (GO:0043092)4.75169711
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.73815602
18exploration behavior (GO:0035640)4.69699708
19glutamate receptor signaling pathway (GO:0007215)4.69153229
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.67403656
21synaptic transmission, glutamatergic (GO:0035249)4.51383857
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50361967
23regulation of dendritic spine morphogenesis (GO:0061001)4.50218905
24regulation of synaptic vesicle exocytosis (GO:2000300)4.46774347
25glutamate secretion (GO:0014047)4.43958871
26regulation of excitatory postsynaptic membrane potential (GO:0060079)4.43945647
27cerebellar granule cell differentiation (GO:0021707)4.40857161
28neuron-neuron synaptic transmission (GO:0007270)4.40801485
29neuronal action potential propagation (GO:0019227)4.37421382
30long-term memory (GO:0007616)4.35053841
31neurotransmitter-gated ion channel clustering (GO:0072578)4.28755871
32dendritic spine morphogenesis (GO:0060997)4.24979397
33negative regulation of dendrite morphogenesis (GO:0050774)4.22726913
34amino acid import (GO:0043090)4.21862512
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.21539489
36regulation of synaptic plasticity (GO:0048167)4.20778472
37regulation of synaptic vesicle transport (GO:1902803)4.14683385
38regulation of postsynaptic membrane potential (GO:0060078)4.11305862
39G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.09352402
40synaptic transmission, dopaminergic (GO:0001963)4.07699986
41behavioral fear response (GO:0001662)4.07101461
42behavioral defense response (GO:0002209)4.07101461
43long-term synaptic potentiation (GO:0060291)4.03820933
44neuron cell-cell adhesion (GO:0007158)4.03378119
45positive regulation of membrane potential (GO:0045838)4.02572796
46positive regulation of synapse maturation (GO:0090129)3.99365582
47positive regulation of neurotransmitter secretion (GO:0001956)3.96900272
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.95403663
49neurotransmitter secretion (GO:0007269)3.92024085
50regulation of ARF protein signal transduction (GO:0032012)3.85594240
51dendritic spine organization (GO:0097061)3.84899786
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.83620472
53regulation of female receptivity (GO:0045924)3.81894605
54positive regulation of neurotransmitter transport (GO:0051590)3.80733839
55regulation of glutamate secretion (GO:0014048)3.78854835
56postsynaptic membrane organization (GO:0001941)3.72044521
57potassium ion homeostasis (GO:0055075)3.71660212
58fear response (GO:0042596)3.71294317
59response to histamine (GO:0034776)3.71209606
60response to amphetamine (GO:0001975)3.68235920
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.67901685
62behavioral response to cocaine (GO:0048148)3.67419052
63regulation of dendritic spine development (GO:0060998)3.66401783
64transmission of nerve impulse (GO:0019226)3.62833212
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.61771242
66cerebellar Purkinje cell differentiation (GO:0021702)3.60458220
67neuromuscular process controlling balance (GO:0050885)3.59987979
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.58275687
69potassium ion import (GO:0010107)3.53809684
70chemosensory behavior (GO:0007635)3.51787047
71neuron recognition (GO:0008038)3.50400949
72positive regulation of dendritic spine development (GO:0060999)3.50366955
73calcium ion-dependent exocytosis (GO:0017156)3.49664797
74female mating behavior (GO:0060180)3.48299840
75prepulse inhibition (GO:0060134)3.46932956
76auditory behavior (GO:0031223)3.46654437
77long term synaptic depression (GO:0060292)3.46010493
78membrane depolarization during action potential (GO:0086010)3.45819253
79cell communication by electrical coupling (GO:0010644)3.45232812
80synaptic vesicle endocytosis (GO:0048488)3.45140581
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44951986
82learning (GO:0007612)3.44856619
83striatum development (GO:0021756)3.42947201
84layer formation in cerebral cortex (GO:0021819)3.41465423
85neuromuscular synaptic transmission (GO:0007274)3.41090953
86cellular potassium ion homeostasis (GO:0030007)3.40939448
87negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40695790
88central nervous system myelination (GO:0022010)3.40369627
89axon ensheathment in central nervous system (GO:0032291)3.40369627
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.40346346
91acidic amino acid transport (GO:0015800)3.38219700
92regulation of vesicle fusion (GO:0031338)3.35625694
93membrane depolarization (GO:0051899)3.35349954
94innervation (GO:0060384)3.31607767
95cytoskeletal anchoring at plasma membrane (GO:0007016)3.29669454
96synaptic transmission (GO:0007268)3.25148125
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24388697
98vesicle docking involved in exocytosis (GO:0006904)3.23799171
99neuronal ion channel clustering (GO:0045161)3.22489473
100activation of protein kinase A activity (GO:0034199)3.21364134
101positive regulation of synaptic transmission (GO:0050806)3.20740455
102negative regulation of amino acid transport (GO:0051956)3.19617028
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19308433
104regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.19267267
105regulation of neurotransmitter secretion (GO:0046928)3.17703353
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.17284506
107neurotransmitter transport (GO:0006836)3.17220383
108gamma-aminobutyric acid transport (GO:0015812)3.16311561
109synaptic vesicle transport (GO:0048489)3.16106845
110establishment of synaptic vesicle localization (GO:0097480)3.16106845
111cellular sodium ion homeostasis (GO:0006883)3.15576894
112regulation of exocytosis (GO:0017157)3.14390083
113regulation of synaptic transmission (GO:0050804)3.14254573
114neuromuscular process controlling posture (GO:0050884)3.12727654
115response to auditory stimulus (GO:0010996)3.12488401
116dopamine receptor signaling pathway (GO:0007212)3.12330416
117axonal fasciculation (GO:0007413)3.10706772
118vesicle transport along microtubule (GO:0047496)3.09256091
119regulation of voltage-gated calcium channel activity (GO:1901385)3.07386908
120signal release (GO:0023061)3.05508068
121positive regulation of dendrite development (GO:1900006)3.05223688
122visual learning (GO:0008542)3.05004951
123detection of calcium ion (GO:0005513)3.04572172
124neuromuscular process (GO:0050905)3.04444310
125regulation of neurotransmitter levels (GO:0001505)3.04380662
126regulation of neurotransmitter transport (GO:0051588)3.04007860
127regulation of synapse maturation (GO:0090128)3.03478047
128serotonin metabolic process (GO:0042428)3.03079938
129dicarboxylic acid transport (GO:0006835)3.02553318
130L-glutamate transport (GO:0015813)3.02124019
131positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00629241
132membrane hyperpolarization (GO:0060081)3.00044038
133proline transport (GO:0015824)2.99273073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.37306868
2GBX2_23144817_ChIP-Seq_PC3_Human3.71425654
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.34843823
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.32709605
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.29845854
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.25973664
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.88410947
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87150917
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87150917
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.85658586
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82784286
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.77128355
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.66111191
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63254545
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61211280
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61013436
17DROSHA_22980978_ChIP-Seq_HELA_Human2.53293010
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.51497713
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49128886
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38659893
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32685641
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.31374697
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.30824168
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.28987218
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.28208750
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85892113
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79129036
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77786499
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77571047
30AR_21572438_ChIP-Seq_LNCaP_Human1.76269042
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74843477
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.70546660
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69308373
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66218759
35TAF15_26573619_Chip-Seq_HEK293_Human1.64219599
36SMAD4_21799915_ChIP-Seq_A2780_Human1.64214534
37TET1_21490601_ChIP-Seq_MESCs_Mouse1.41994173
38P300_19829295_ChIP-Seq_ESCs_Human1.38862462
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36721964
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36321058
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34819190
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34555731
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.34477240
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.33992739
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32648442
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31781789
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30680103
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30238207
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27445078
50ZNF274_21170338_ChIP-Seq_K562_Hela1.27381222
51LXR_22292898_ChIP-Seq_THP-1_Human1.26427852
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25744368
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25411768
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.24052100
55AR_25329375_ChIP-Seq_VCAP_Human1.22913232
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21529890
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20948267
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19712162
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18639275
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18404820
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15388975
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14268531
63* AR_19668381_ChIP-Seq_PC3_Human1.14259580
64STAT3_23295773_ChIP-Seq_U87_Human1.14060764
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13180635
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.11651403
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.11072227
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10946944
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10787590
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09905924
71SMC4_20622854_ChIP-Seq_HELA_Human1.08302661
72TP53_16413492_ChIP-PET_HCT116_Human1.07575570
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06396428
74OCT4_19829295_ChIP-Seq_ESCs_Human1.05871438
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03251046
76TCF4_23295773_ChIP-Seq_U87_Human1.03164370
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02993514
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02796688
79FUS_26573619_Chip-Seq_HEK293_Human1.02570830
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.02463119
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.01889017
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01764951
83* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01491149
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01170206
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01118080
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01088402
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.00376567
88SMAD_19615063_ChIP-ChIP_OVARY_Human0.99986886
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.99534433
90* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97884350
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97499192
92* KDM2B_26808549_Chip-Seq_K562_Human0.97241216
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97211114
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97199472
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.97032925
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96462341
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96416010
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96197369
99VDR_22108803_ChIP-Seq_LS180_Human0.95764071
100DPY_21335234_ChIP-Seq_ESCs_Mouse0.95522124
101RUNX2_22187159_ChIP-Seq_PCA_Human0.95248501
102JUN_21703547_ChIP-Seq_K562_Human0.94804827
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94775599
104* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94398611
105KLF4_19829295_ChIP-Seq_ESCs_Human0.94173184
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92685025
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92653058
108POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91253715
109RXR_22108803_ChIP-Seq_LS180_Human0.90674100
110AHR_22903824_ChIP-Seq_MCF-7_Human0.89698667
111BCAT_22108803_ChIP-Seq_LS180_Human0.89629309
112TP53_18474530_ChIP-ChIP_U2OS_Human0.88429840
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88416006
114* RNF2_27304074_Chip-Seq_NSC_Mouse0.87749748
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87728008
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.87694785
117P68_20966046_ChIP-Seq_HELA_Human0.87550792
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87228801
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87228801
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.86454975
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85614925
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84901931
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.84607560
124* CTCF_27219007_Chip-Seq_Bcells_Human0.84425236
125RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84424141
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84095758
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83355454
128SMAD4_21741376_ChIP-Seq_ESCs_Human0.80997425
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.79871804
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79017587
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73802933
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73170554
133* CREB1_26743006_Chip-Seq_LNCaP_Human0.71882847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.59117265
2MP0003880_abnormal_central_pattern5.79787951
3MP0002822_catalepsy4.64802530
4MP0003635_abnormal_synaptic_transmissio4.43557357
5MP0009745_abnormal_behavioral_response3.77349888
6MP0002063_abnormal_learning/memory/cond3.74575227
7MP0004270_analgesia3.71683728
8MP0002064_seizures3.23582907
9MP0002572_abnormal_emotion/affect_behav2.99133019
10MP0001968_abnormal_touch/_nociception2.96505338
11MP0002272_abnormal_nervous_system2.65601119
12MP0001486_abnormal_startle_reflex2.54474010
13MP0001501_abnormal_sleep_pattern2.54167401
14MP0009046_muscle_twitch2.53597260
15MP0002736_abnormal_nociception_after2.47606195
16MP0002734_abnormal_mechanical_nocicepti2.19201067
17MP0001440_abnormal_grooming_behavior2.09639297
18MP0005423_abnormal_somatic_nervous2.08332992
19MP0002735_abnormal_chemical_nociception2.03186447
20MP0001529_abnormal_vocalization2.00732273
21MP0009780_abnormal_chondrocyte_physiolo1.93627660
22MP0002909_abnormal_adrenal_gland1.87713289
23MP0003329_amyloid_beta_deposits1.85868893
24MP0001970_abnormal_pain_threshold1.78777434
25MP0002733_abnormal_thermal_nociception1.75113838
26MP0002067_abnormal_sensory_capabilities1.72025033
27MP0005646_abnormal_pituitary_gland1.70205053
28MP0005386_behavior/neurological_phenoty1.65597350
29MP0004924_abnormal_behavior1.65597350
30MP0008569_lethality_at_weaning1.64321366
31* MP0004811_abnormal_neuron_physiology1.63602269
32MP0002557_abnormal_social/conspecific_i1.62169004
33MP0002184_abnormal_innervation1.56335801
34MP0000778_abnormal_nervous_system1.52507835
35MP0003879_abnormal_hair_cell1.52037121
36MP0003787_abnormal_imprinting1.44407594
37MP0001188_hyperpigmentation1.43730934
38MP0004858_abnormal_nervous_system1.42031924
39MP0003123_paternal_imprinting1.41298075
40MP0001905_abnormal_dopamine_level1.40689154
41MP0001984_abnormal_olfaction1.40077662
42MP0005409_darkened_coat_color1.37065137
43MP0002066_abnormal_motor_capabilities/c1.34758705
44MP0000955_abnormal_spinal_cord1.33662934
45MP0003075_altered_response_to1.32509580
46MP0003633_abnormal_nervous_system1.31760544
47MP0005410_abnormal_fertilization1.31448796
48MP0006276_abnormal_autonomic_nervous1.25835532
49MP0004885_abnormal_endolymph1.25282662
50* MP0002882_abnormal_neuron_morphology1.24093401
51MP0001502_abnormal_circadian_rhythm1.14868251
52MP0002837_dystrophic_cardiac_calcinosis1.10160623
53MP0008874_decreased_physiological_sensi1.09787083
54MP0003631_nervous_system_phenotype1.08492563
55MP0008872_abnormal_physiological_respon1.06675901
56MP0001348_abnormal_lacrimal_gland1.02102781
57MP0000013_abnormal_adipose_tissue0.97724712
58MP0005535_abnormal_body_temperature0.97713332
59* MP0002152_abnormal_brain_morphology0.96541202
60MP0002069_abnormal_eating/drinking_beha0.96033567
61MP0000751_myopathy0.91045639
62MP0001177_atelectasis0.89440154
63MP0008877_abnormal_DNA_methylation0.89163585
64MP0004510_myositis0.89126662
65MP0001346_abnormal_lacrimal_gland0.88265745
66MP0004085_abnormal_heartbeat0.88034737
67MP0000604_amyloidosis0.87726181
68MP0004142_abnormal_muscle_tone0.86568418
69MP0005645_abnormal_hypothalamus_physiol0.85014713
70MP0010234_abnormal_vibrissa_follicle0.83211619
71MP0010386_abnormal_urinary_bladder0.81943072
72MP0005167_abnormal_blood-brain_barrier0.81518809
73MP0004484_altered_response_of0.79894219
74MP0005623_abnormal_meninges_morphology0.78631239
75MP0004145_abnormal_muscle_electrophysio0.78185456
76MP0002638_abnormal_pupillary_reflex0.77284045
77MP0005394_taste/olfaction_phenotype0.76757603
78MP0005499_abnormal_olfactory_system0.76757603
79MP0005551_abnormal_eye_electrophysiolog0.74709939
80* MP0002229_neurodegeneration0.74155274
81MP0001664_abnormal_digestion0.71355396
82MP0001963_abnormal_hearing_physiology0.70518495
83MP0004147_increased_porphyrin_level0.70331268
84MP0002090_abnormal_vision0.69704946
85MP0008961_abnormal_basal_metabolism0.69272732
86MP0000920_abnormal_myelination0.68298861
87MP0001986_abnormal_taste_sensitivity0.67923852
88MP0003122_maternal_imprinting0.66948541
89MP0003690_abnormal_glial_cell0.65052474
90MP0003172_abnormal_lysosome_physiology0.64692238
91MP0003634_abnormal_glial_cell0.64663193
92MP0003632_abnormal_nervous_system0.64650550
93MP0001765_abnormal_ion_homeostasis0.64642100
94MP0004215_abnormal_myocardial_fiber0.63900158
95MP0002876_abnormal_thyroid_physiology0.62900404
96MP0004742_abnormal_vestibular_system0.61705352
97MP0003283_abnormal_digestive_organ0.61577415
98MP0001485_abnormal_pinna_reflex0.60517124
99MP0000631_abnormal_neuroendocrine_gland0.60290614
100MP0006292_abnormal_olfactory_placode0.59627104
101MP0003183_abnormal_peptide_metabolism0.58460863
102MP0002234_abnormal_pharynx_morphology0.56680053
103MP0003698_abnormal_male_reproductive0.56193834
104MP0005166_decreased_susceptibility_to0.55931784
105MP0003137_abnormal_impulse_conducting0.55694781
106MP0002752_abnormal_somatic_nervous0.55682053
107MP0004130_abnormal_muscle_cell0.54687486
108MP0003121_genomic_imprinting0.51628989
109MP0000026_abnormal_inner_ear0.50004124
110MP0010768_mortality/aging0.48581821
111MP0005595_abnormal_vascular_smooth0.47567289
112MP0004233_abnormal_muscle_weight0.47512606
113MP0010770_preweaning_lethality0.47486357
114MP0002082_postnatal_lethality0.47486357
115MP0001943_abnormal_respiration0.46129442
116MP0003956_abnormal_body_size0.45783830
117MP0002873_normal_phenotype0.43306332
118MP0003861_abnormal_nervous_system0.43125604
119MP0005620_abnormal_muscle_contractility0.41775719
120MP0010769_abnormal_survival0.41052673

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.01906715
2Myokymia (HP:0002411)8.33943956
3Focal seizures (HP:0007359)6.24430591
4Visual hallucinations (HP:0002367)5.44126072
5Epileptic encephalopathy (HP:0200134)4.90492520
6Atonic seizures (HP:0010819)4.61159365
7Absence seizures (HP:0002121)4.47464783
8Febrile seizures (HP:0002373)4.34609406
9Dialeptic seizures (HP:0011146)4.18568972
10Hyperventilation (HP:0002883)4.16796442
11Generalized tonic-clonic seizures (HP:0002069)4.04528960
12Action tremor (HP:0002345)3.88016690
13Progressive cerebellar ataxia (HP:0002073)3.83545185
14Broad-based gait (HP:0002136)3.80905399
15Impaired vibration sensation in the lower limbs (HP:0002166)3.77713342
16Poor eye contact (HP:0000817)3.72955393
17Anxiety (HP:0000739)3.69201848
18Amblyopia (HP:0000646)3.68242414
19Depression (HP:0000716)3.47490068
20Supranuclear gaze palsy (HP:0000605)3.43154734
21Cerebral inclusion bodies (HP:0100314)3.40449659
22Dysmetria (HP:0001310)3.40077385
23Cerebral hypomyelination (HP:0006808)3.38562111
24Abnormal social behavior (HP:0012433)3.34421024
25Impaired social interactions (HP:0000735)3.34421024
26Tetraplegia (HP:0002445)3.34202412
27Dysdiadochokinesis (HP:0002075)3.29252374
28Limb dystonia (HP:0002451)3.25945156
29Gaze-evoked nystagmus (HP:0000640)3.25578499
30Annular pancreas (HP:0001734)3.15948536
31Abnormality of the lower motor neuron (HP:0002366)3.14358480
32Truncal ataxia (HP:0002078)3.07119599
33Urinary bladder sphincter dysfunction (HP:0002839)3.00753565
34Torticollis (HP:0000473)3.00630510
35Neurofibrillary tangles (HP:0002185)2.95075556
36Akinesia (HP:0002304)2.94594330
37Focal dystonia (HP:0004373)2.93207572
38Ankle clonus (HP:0011448)2.87494461
39Impaired smooth pursuit (HP:0007772)2.83781285
40Stereotypic behavior (HP:0000733)2.82723369
41Postural instability (HP:0002172)2.82446863
42Excessive salivation (HP:0003781)2.71912949
43Drooling (HP:0002307)2.71912949
44Clonus (HP:0002169)2.71230299
45Abnormal eating behavior (HP:0100738)2.71002086
46Urinary urgency (HP:0000012)2.65698285
47Delusions (HP:0000746)2.61352162
48Epileptiform EEG discharges (HP:0011182)2.60187304
49Bradykinesia (HP:0002067)2.60161480
50Scanning speech (HP:0002168)2.59324712
51Impaired vibratory sensation (HP:0002495)2.58473706
52Hemiparesis (HP:0001269)2.57821586
53Craniofacial dystonia (HP:0012179)2.56633676
54Resting tremor (HP:0002322)2.56620130
55Peripheral hypomyelination (HP:0007182)2.55497160
56Abnormality of binocular vision (HP:0011514)2.49539074
57Diplopia (HP:0000651)2.49539074
58Abnormality of the corticospinal tract (HP:0002492)2.47720009
59Dysmetric saccades (HP:0000641)2.43034017
60Hydroureter (HP:0000072)2.38439710
61Spastic tetraparesis (HP:0001285)2.38228876
62Mutism (HP:0002300)2.36782888
63Diminished motivation (HP:0000745)2.35815793
64Slow saccadic eye movements (HP:0000514)2.35078317
65Testicular atrophy (HP:0000029)2.34962083
66Intention tremor (HP:0002080)2.34378730
67Spastic gait (HP:0002064)2.34243401
68Absent speech (HP:0001344)2.34080483
69Sleep apnea (HP:0010535)2.33339543
70Abnormality of ocular smooth pursuit (HP:0000617)2.33293559
71Progressive inability to walk (HP:0002505)2.30746000
72EEG with generalized epileptiform discharges (HP:0011198)2.30719133
73Ankyloglossia (HP:0010296)2.28958872
74Pointed chin (HP:0000307)2.28025224
75Megalencephaly (HP:0001355)2.27787028
76Papilledema (HP:0001085)2.26789040
77Abnormality of saccadic eye movements (HP:0000570)2.25900964
78Insidious onset (HP:0003587)2.24358807
79Termporal pattern (HP:0011008)2.24358807
80Incomplete penetrance (HP:0003829)2.24340226
81Lower limb asymmetry (HP:0100559)2.23189262
82Polyphagia (HP:0002591)2.20848125
83Genetic anticipation (HP:0003743)2.19204813
84Ventricular fibrillation (HP:0001663)2.16584962
85Status epilepticus (HP:0002133)2.16299521
86Lower limb amyotrophy (HP:0007210)2.15495727
87Generalized myoclonic seizures (HP:0002123)2.15112398
88Hypsarrhythmia (HP:0002521)2.15071679
89CNS hypomyelination (HP:0003429)2.04651100
90Inability to walk (HP:0002540)2.04641353
91Choreoathetosis (HP:0001266)2.04480046
92Lower limb muscle weakness (HP:0007340)2.03718821
93Rapidly progressive (HP:0003678)2.02131028
94Gait ataxia (HP:0002066)1.99195904
95Psychosis (HP:0000709)1.95454169
96Deep palmar crease (HP:0006191)1.95204953
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.94719855
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94719855
99Thickened helices (HP:0000391)1.93960813
100Abnormal EKG (HP:0003115)1.93550593
101Fetal akinesia sequence (HP:0001989)1.93545552
102Morphological abnormality of the pyramidal tract (HP:0002062)1.91930595
103Hemiplegia (HP:0002301)1.91699998
104Increased circulating renin level (HP:0000848)1.88977525
105Abnormality of salivation (HP:0100755)1.87638884
106Bundle branch block (HP:0011710)1.85988958
107Global brain atrophy (HP:0002283)1.84859303
108Memory impairment (HP:0002354)1.84786994
109Neuronal loss in central nervous system (HP:0002529)1.83289651
110Insomnia (HP:0100785)1.82320402
111Hand muscle atrophy (HP:0009130)1.81006467
112Nuclear cataract (HP:0100018)1.80202914
113Apathy (HP:0000741)1.80092253
114Protruding tongue (HP:0010808)1.79025235
115Palpebral edema (HP:0100540)1.78984121
116Spinal canal stenosis (HP:0003416)1.78583370
117Dementia (HP:0000726)1.77419070
118Blue irides (HP:0000635)1.77018328
119Abnormality of oral frenula (HP:0000190)1.76904460
120Rigidity (HP:0002063)1.76782327
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75646774
122Deeply set eye (HP:0000490)1.75141003
123Limb ataxia (HP:0002070)1.74050925
124Split foot (HP:0001839)1.73368624
125Distal upper limb amyotrophy (HP:0007149)1.73000510
126Upper limb amyotrophy (HP:0009129)1.73000510
127Obstructive sleep apnea (HP:0002870)1.72232971
128Amyotrophic lateral sclerosis (HP:0007354)1.70228013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.13682389
2NTRK34.66261423
3RIPK43.98988051
4MAP3K93.26528642
5DAPK22.55930581
6MINK12.49935897
7MAP3K42.48194526
8KSR22.42304607
9PRKD32.25463918
10MAP2K72.04521111
11DAPK12.04393385
12MAP3K122.03084357
13ARAF1.96673932
14KSR11.82385419
15MAP3K131.80475735
16BMPR21.78912741
17PAK61.76110982
18CAMKK11.74540763
19FES1.67834757
20PTK2B1.60743224
21NTRK11.58204506
22MAP2K41.57775249
23PLK21.56316922
24CDK51.52854949
25CASK1.50464939
26MARK11.45808959
27TESK11.39576595
28GRK51.38598264
29NTRK21.35180802
30PRPF4B1.34653150
31SIK21.33559570
32RAF11.30259055
33STK381.21246574
34NME11.21152629
35PRKCG1.20720207
36PNCK1.18989692
37MAP3K21.15080830
38CAMK2B1.13956394
39RIPK11.13953127
40TNIK1.11032113
41CAMK2A1.10807325
42TYRO31.00019567
43CDK190.96529206
44MAP3K110.94130041
45FGR0.90756351
46BRSK10.89111375
47PINK10.85722117
48CAMK10.84782364
49CDK180.81236842
50CDK150.78726136
51CAMKK20.78187511
52MAPK120.77817476
53CDK140.76916466
54TAOK10.74670444
55SGK4940.72701260
56SGK2230.72701260
57SGK10.71201222
58PDK10.70550175
59CDK11A0.68744851
60UHMK10.68293102
61PKN10.67959027
62STK110.67117807
63MAPK130.67041162
64PDPK10.65548716
65TNK20.63691453
66PRKCH0.62890610
67MAP3K10.62518539
68SGK20.60317008
69DYRK1A0.59207897
70LIMK10.57821768
71MAP3K70.57105274
72CAMK1G0.55905016
73RET0.54259379
74CAMK2D0.53898610
75GRK60.52691686
76MAP2K10.52085096
77BRAF0.52052302
78FER0.51992583
79SGK30.49617696
80MARK20.48864833
81DAPK30.48815273
82OXSR10.48692966
83DMPK0.46370510
84FYN0.46333022
85PRKCZ0.45303554
86MOS0.44863096
87CCNB10.44427903
88PRKCE0.44192998
89CAMK2G0.43033412
90RPS6KA30.42886392
91MAPK100.42586264
92PAK30.42325253
93MAP2K60.39659901
94CAMK1D0.38206005
95PRKG20.37689667
96PRKD20.37455795
97LMTK20.37400645
98NEK60.37097606
99FGFR20.36961771
100CAMK40.35476360
101WNK10.35134520
102PRKCQ0.34400712
103LATS20.34002616
104ALK0.33594600
105CSNK1G20.31915971
106SIK30.31304921
107ROCK20.31128502
108PRKCA0.30698240
109NEK10.30108987
110DDR20.30103869
111PRKCB0.29917089
112ROCK10.29804262
113MAPK80.28680462
114PRKG10.28355172
115AKT30.28227845
116PRKACA0.27658583
117PHKG20.24512482
118PHKG10.24512482
119CSNK1A10.23699904
120GSK3B0.23446980
121IRAK20.22977232

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.76073685
2Long-term potentiation_Homo sapiens_hsa047203.26173912
3Olfactory transduction_Homo sapiens_hsa047403.06796225
4Amphetamine addiction_Homo sapiens_hsa050312.98135158
5Circadian entrainment_Homo sapiens_hsa047132.89524517
6Synaptic vesicle cycle_Homo sapiens_hsa047212.79993503
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72351444
8Glutamatergic synapse_Homo sapiens_hsa047242.71242773
9Morphine addiction_Homo sapiens_hsa050322.61109254
10GABAergic synapse_Homo sapiens_hsa047272.57007911
11Salivary secretion_Homo sapiens_hsa049702.40679647
12Dopaminergic synapse_Homo sapiens_hsa047282.33821780
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12502587
14Gastric acid secretion_Homo sapiens_hsa049712.01179658
15Renin secretion_Homo sapiens_hsa049242.00656319
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99310520
17Cholinergic synapse_Homo sapiens_hsa047251.94976022
18Insulin secretion_Homo sapiens_hsa049111.88403141
19Calcium signaling pathway_Homo sapiens_hsa040201.88236516
20Oxytocin signaling pathway_Homo sapiens_hsa049211.84867267
21Cocaine addiction_Homo sapiens_hsa050301.76325909
22Vitamin B6 metabolism_Homo sapiens_hsa007501.75010544
23Taste transduction_Homo sapiens_hsa047421.74624111
24Long-term depression_Homo sapiens_hsa047301.74548486
25Serotonergic synapse_Homo sapiens_hsa047261.66587689
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66259296
27GnRH signaling pathway_Homo sapiens_hsa049121.56791961
28Collecting duct acid secretion_Homo sapiens_hsa049661.46960606
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43797861
30Gap junction_Homo sapiens_hsa045401.38488975
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35702887
32cAMP signaling pathway_Homo sapiens_hsa040241.34913955
33Glioma_Homo sapiens_hsa052141.27624789
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24683324
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13759278
36Melanogenesis_Homo sapiens_hsa049161.09550211
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08932655
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06773026
39Estrogen signaling pathway_Homo sapiens_hsa049151.06746091
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05128857
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.04666646
42Phototransduction_Homo sapiens_hsa047441.03727293
43Cardiac muscle contraction_Homo sapiens_hsa042601.02275202
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00831068
45Axon guidance_Homo sapiens_hsa043600.96291663
46Oocyte meiosis_Homo sapiens_hsa041140.96244472
47Pancreatic secretion_Homo sapiens_hsa049720.92341938
48ErbB signaling pathway_Homo sapiens_hsa040120.91572219
49Type II diabetes mellitus_Homo sapiens_hsa049300.89367687
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87767871
51VEGF signaling pathway_Homo sapiens_hsa043700.87416972
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86119904
53Vibrio cholerae infection_Homo sapiens_hsa051100.85482095
54Nitrogen metabolism_Homo sapiens_hsa009100.83313503
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82188796
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.80046521
57African trypanosomiasis_Homo sapiens_hsa051430.78362939
58Thyroid hormone synthesis_Homo sapiens_hsa049180.77633200
59Choline metabolism in cancer_Homo sapiens_hsa052310.77117445
60Alzheimers disease_Homo sapiens_hsa050100.73124680
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73079027
62Fatty acid biosynthesis_Homo sapiens_hsa000610.69484721
63Glucagon signaling pathway_Homo sapiens_hsa049220.69399545
64Rap1 signaling pathway_Homo sapiens_hsa040150.64996225
65Dilated cardiomyopathy_Homo sapiens_hsa054140.64676978
66MAPK signaling pathway_Homo sapiens_hsa040100.63839433
67Dorso-ventral axis formation_Homo sapiens_hsa043200.63001329
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61223451
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59278752
70Non-small cell lung cancer_Homo sapiens_hsa052230.57444162
71Ras signaling pathway_Homo sapiens_hsa040140.55187932
72Alcoholism_Homo sapiens_hsa050340.52915170
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.52614629
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51988753
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50316043
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50254095
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.48361160
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48292427
79Type I diabetes mellitus_Homo sapiens_hsa049400.47919383
80Arginine and proline metabolism_Homo sapiens_hsa003300.46019421
81Inositol phosphate metabolism_Homo sapiens_hsa005620.45151872
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44929086
83mTOR signaling pathway_Homo sapiens_hsa041500.44893754
84Arginine biosynthesis_Homo sapiens_hsa002200.40564345
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40395408
86Bile secretion_Homo sapiens_hsa049760.39983180
87Prion diseases_Homo sapiens_hsa050200.39163134
88Oxidative phosphorylation_Homo sapiens_hsa001900.38061266
89Endocytosis_Homo sapiens_hsa041440.37047432
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36871360
91Wnt signaling pathway_Homo sapiens_hsa043100.36112369
92Parkinsons disease_Homo sapiens_hsa050120.34842155
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33288034
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32558001
95Chemokine signaling pathway_Homo sapiens_hsa040620.31179319
96Circadian rhythm_Homo sapiens_hsa047100.30637014
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27782823
98Mineral absorption_Homo sapiens_hsa049780.27265360
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23697347
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23416307
101Insulin signaling pathway_Homo sapiens_hsa049100.23060606
102Renal cell carcinoma_Homo sapiens_hsa052110.22156668
103Platelet activation_Homo sapiens_hsa046110.22083233
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22060863
105Tight junction_Homo sapiens_hsa045300.21910009
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21007525
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20907571
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20413106
109Ovarian steroidogenesis_Homo sapiens_hsa049130.20037932
110HIF-1 signaling pathway_Homo sapiens_hsa040660.19996270
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19402823
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.19228413
113Histidine metabolism_Homo sapiens_hsa003400.16973412
114AMPK signaling pathway_Homo sapiens_hsa041520.14380764

Most similar genes based on co-expression Upload to Enrichr

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