HPCAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.10720707
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.99546621
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58031785
4glutamate secretion (GO:0014047)4.12905974
5protein localization to endosome (GO:0036010)3.72199688
6respiratory burst (GO:0045730)3.67681547
7neutrophil activation (GO:0042119)3.56421545
8positive regulation of mast cell activation (GO:0033005)3.54101818
9positive regulation of mast cell degranulation (GO:0043306)3.52904229
10positive regulation of mast cell activation involved in immune response (GO:0033008)3.52904229
11granulocyte activation (GO:0036230)3.51980562
12phagosome maturation (GO:0090382)3.44972719
13sequestering of actin monomers (GO:0042989)3.40072237
14interferon-gamma-mediated signaling pathway (GO:0060333)3.37101458
15negative regulation of erythrocyte differentiation (GO:0045647)3.31904745
16eosinophil chemotaxis (GO:0048245)3.30360423
17signal complex assembly (GO:0007172)3.23933243
18myeloid dendritic cell differentiation (GO:0043011)3.20042499
19immunoglobulin mediated immune response (GO:0016064)3.16224549
20G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15240604
21regulation of ARF protein signal transduction (GO:0032012)3.09485727
22cellular response to type I interferon (GO:0071357)3.06118466
23type I interferon signaling pathway (GO:0060337)3.06118466
24response to peptidoglycan (GO:0032494)3.04581723
25regulation of T-helper 1 cell differentiation (GO:0045625)3.03500829
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01154923
27response to type I interferon (GO:0034340)2.99328072
28myeloid dendritic cell activation (GO:0001773)2.98834203
29negative regulation of cell killing (GO:0031342)2.96773529
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96773529
31leukocyte aggregation (GO:0070486)2.93884178
32Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93681544
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91460191
34eosinophil migration (GO:0072677)2.91319236
35positive regulation of synapse maturation (GO:0090129)2.90828961
36detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.86130543
37detection of temperature stimulus involved in sensory perception (GO:0050961)2.86130543
38positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.86037750
39regulation of early endosome to late endosome transport (GO:2000641)2.84873187
40positive regulation of interferon-alpha production (GO:0032727)2.83920809
41adenosine receptor signaling pathway (GO:0001973)2.83708426
42synaptic vesicle maturation (GO:0016188)2.83705401
43production of molecular mediator involved in inflammatory response (GO:0002532)2.81395104
44myeloid cell activation involved in immune response (GO:0002275)2.80251218
45cerebellar granule cell differentiation (GO:0021707)2.79969065
46layer formation in cerebral cortex (GO:0021819)2.79239563
47barbed-end actin filament capping (GO:0051016)2.78714761
48regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76684203
49neurotransmitter secretion (GO:0007269)2.74346735
50regulation of B cell receptor signaling pathway (GO:0050855)2.74078230
51positive regulation of regulated secretory pathway (GO:1903307)2.73449513
52leukocyte mediated cytotoxicity (GO:0001909)2.72798964
53response to pheromone (GO:0019236)2.72643855
54negative regulation of interleukin-17 production (GO:0032700)2.71514166
55regulation of mast cell degranulation (GO:0043304)2.71261102
56regulation of T-helper 2 cell differentiation (GO:0045628)2.70813302
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.70136085
58regulation of amyloid precursor protein catabolic process (GO:1902991)2.70134232
59activation of Rac GTPase activity (GO:0032863)2.69715449
60regulation of leukocyte degranulation (GO:0043300)2.69124597
61regulation of necrotic cell death (GO:0010939)2.68569651
62regulation of synaptic vesicle transport (GO:1902803)2.68493904
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68306304
64regulation of hypersensitivity (GO:0002883)2.68094883
65monocyte chemotaxis (GO:0002548)2.67090575
66negative regulation of necrotic cell death (GO:0060547)2.67067247
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66121898
68positive regulation of monocyte chemotaxis (GO:0090026)2.65160679
69regulation of interferon-alpha production (GO:0032647)2.64554312
70cellular response to zinc ion (GO:0071294)2.64440978
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63144947
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.63144947
73modulation by symbiont of host immune response (GO:0052553)2.63144947
74positive regulation by symbiont of host defense response (GO:0052509)2.63144947
75modulation by symbiont of host defense response (GO:0052031)2.63144947
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63144947
77positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61649550
78sodium ion export (GO:0071436)2.60731369
79hydrogen peroxide biosynthetic process (GO:0050665)2.60688441
80dendritic cell differentiation (GO:0097028)2.60075155
81antigen processing and presentation of endogenous antigen (GO:0019883)2.58192868
82positive regulation of protein dephosphorylation (GO:0035307)2.58169721
83positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57532940
84positive regulation of macrophage differentiation (GO:0045651)2.56521367
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55269868
86mast cell activation (GO:0045576)2.53321317
87amino acid import (GO:0043090)2.52811456
88detection of temperature stimulus (GO:0016048)2.52773992
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51494569
90positive regulation of antigen processing and presentation (GO:0002579)2.51474840
91leukocyte degranulation (GO:0043299)2.50851193
92negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50751005
93cellular potassium ion homeostasis (GO:0030007)2.50037565
94positive regulation of T-helper cell differentiation (GO:0045624)2.49629541
95regulation of defense response to virus by virus (GO:0050690)2.48522169
96positive regulation of leukocyte degranulation (GO:0043302)2.47954198
97behavioral response to pain (GO:0048266)2.47778762
98L-amino acid import (GO:0043092)2.47096483
99positive regulation of macrophage cytokine production (GO:0060907)2.46737012
100regulation of regulated secretory pathway (GO:1903305)2.46133756
101regulation of mast cell activation involved in immune response (GO:0033006)2.45993612
102cellular response to thyroid hormone stimulus (GO:0097067)2.45810159
103neuronal action potential propagation (GO:0019227)2.45736370
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45693640
105transferrin transport (GO:0033572)2.45387621
106macrophage activation involved in immune response (GO:0002281)2.45007735
107positive regulation of neurotransmitter secretion (GO:0001956)2.44985283
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44313237
109regulation of mast cell activation (GO:0033003)2.43801030
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43689013
111synaptic vesicle exocytosis (GO:0016079)2.43610196
112leukocyte cell-cell adhesion (GO:0007159)2.42641672
113regulation of mononuclear cell migration (GO:0071675)2.42630397
114protein retention in ER lumen (GO:0006621)2.42233738
115response to muramyl dipeptide (GO:0032495)2.39595853
116cerebellar Purkinje cell differentiation (GO:0021702)2.39524201
117regulation of synaptic vesicle exocytosis (GO:2000300)2.39378354
118regulation of monocyte chemotaxis (GO:0090025)2.37975186
119response to gravity (GO:0009629)2.37818717
120energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.37007606
121ATP hydrolysis coupled proton transport (GO:0015991)2.37007606
122actin nucleation (GO:0045010)2.36880438
123regulation of superoxide anion generation (GO:0032928)2.36063854
124myeloid leukocyte mediated immunity (GO:0002444)2.35294574
125negative regulation of necroptotic process (GO:0060546)2.35131516
126regulation of beta-amyloid formation (GO:1902003)2.34787954
127cellular response to nicotine (GO:0071316)2.34391376
128myeloid leukocyte activation (GO:0002274)2.33293236
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.32428724
130defense response to protozoan (GO:0042832)2.32317909
131cellular response to interferon-gamma (GO:0071346)2.30739585
132regulation of RIG-I signaling pathway (GO:0039535)2.28766580
133positive regulation of T-helper 1 type immune response (GO:0002827)2.27889671
134regulation of alpha-beta T cell proliferation (GO:0046640)2.27736876
135regulation of synaptic plasticity (GO:0048167)2.27701113
136reactive oxygen species biosynthetic process (GO:1903409)2.27199582
137mature B cell differentiation involved in immune response (GO:0002313)2.25995045
138regulation of neuronal synaptic plasticity (GO:0048168)2.24173633
139positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23603479
140pinocytosis (GO:0006907)2.23391966
141protein targeting to plasma membrane (GO:0072661)2.22515025
142neuromuscular process controlling balance (GO:0050885)2.20352193
143actin filament depolymerization (GO:0030042)2.19846304
144positive regulation of Rap GTPase activity (GO:0032854)2.19747910
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19595213
146positive regulation of gamma-delta T cell activation (GO:0046645)2.18644264
147response to manganese ion (GO:0010042)2.18092548
148negative regulation of type 2 immune response (GO:0002829)2.18080467
149cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.17426901
150cell-cell junction maintenance (GO:0045217)2.14973832
151negative regulation of ERBB signaling pathway (GO:1901185)2.14605342
152regulation of ARF GTPase activity (GO:0032312)2.13739435
153modulation by symbiont of host cellular process (GO:0044068)2.12383185
154potassium ion homeostasis (GO:0055075)2.11975402
155stress fiber assembly (GO:0043149)2.11863026
156endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.11399909
157regulation of synapse maturation (GO:0090128)2.11128947
158G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.10777411
159angiogenesis involved in wound healing (GO:0060055)2.10234840
160glycosphingolipid catabolic process (GO:0046479)2.09396637
161negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.08887818
162cellular copper ion homeostasis (GO:0006878)2.08645101
163regulation of protein dephosphorylation (GO:0035304)2.08009651
164regulation of necroptotic process (GO:0060544)2.07704235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.08664722
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.45455508
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.09609457
4IKZF1_21737484_ChIP-ChIP_HCT116_Human3.66821808
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26883682
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22595843
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87714330
8* IRF8_27001747_Chip-Seq_BMDM_Mouse2.86881247
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79643119
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69909005
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66599877
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65803171
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63426972
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51803134
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47388853
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16989716
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06815700
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04720356
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.03683127
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01451822
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98845977
22* RACK7_27058665_Chip-Seq_MCF-7_Human1.91126289
23RUNX_20019798_ChIP-Seq_JUKART_Human1.86300117
24TCF7_22412390_ChIP-Seq_EML_Mouse1.80804194
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78621173
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76529406
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75641890
28MYC_22102868_ChIP-Seq_BL_Human1.75019489
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.68608175
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68091413
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.67907837
32SPI1_23127762_ChIP-Seq_K562_Human1.67871841
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60974551
34P68_20966046_ChIP-Seq_HELA_Human1.60688151
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60614036
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59369796
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57741876
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54842984
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53434190
40ZNF263_19887448_ChIP-Seq_K562_Human1.51907853
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.51709666
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.50813468
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.50451469
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.46349224
45* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43587603
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43212472
47* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42247297
48* VDR_24763502_ChIP-Seq_THP-1_Human1.41023010
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.40599802
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40104604
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.39862708
52* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39500333
53MYB_26560356_Chip-Seq_TH2_Human1.39391324
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39209955
55SPI1_23547873_ChIP-Seq_NB4_Human1.37881669
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.36447704
57* BCL6_27268052_Chip-Seq_Bcells_Human1.36162115
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35437986
59* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35344569
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35135846
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35084364
62SMC4_20622854_ChIP-Seq_HELA_Human1.34848645
63* BCOR_27268052_Chip-Seq_Bcells_Human1.34786321
64* KDM2B_26808549_Chip-Seq_JURKAT_Human1.33419978
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32835293
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32696992
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32530332
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27915952
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27696620
70EZH2_22144423_ChIP-Seq_EOC_Human1.27143370
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26891601
72* SCL_19346495_ChIP-Seq_HPC-7_Human1.26530268
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26155431
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25963502
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25952563
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25928815
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24488355
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23145119
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21271317
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21271317
81VDR_24787735_ChIP-Seq_THP-1_Human1.20480380
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20348544
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20286586
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20282511
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20240267
86* MAF_26560356_Chip-Seq_TH2_Human1.20046202
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.17966931
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17918591
89LXR_22292898_ChIP-Seq_THP-1_Human1.17455000
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17158630
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16039830
92DROSHA_22980978_ChIP-Seq_HELA_Human1.14680810
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13583602
94MAF_26560356_Chip-Seq_TH1_Human1.13487038
95* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12308152
96GATA1_19941826_ChIP-Seq_K562_Human1.12185677
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12092329
98REST_21632747_ChIP-Seq_MESCs_Mouse1.12055101
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11667110
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10889068
101SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10207984
102CREB1_26743006_Chip-Seq_LNCaP_Human1.09862973
103* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08827235
104* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08446201
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08243837
106* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08202331
107GATA3_27048872_Chip-Seq_THYMUS_Human1.07245540
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06948460
109* PU_27001747_Chip-Seq_BMDM_Mouse1.06779151
110TP53_22127205_ChIP-Seq_IMR90_Human1.06651435
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06097476
112* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05584510
113TET1_21490601_ChIP-Seq_MESCs_Mouse1.05361036
114ATF3_27146783_Chip-Seq_COLON_Human1.04607353
115* KDM2B_26808549_Chip-Seq_DND41_Human1.04579985
116SOX2_20726797_ChIP-Seq_SW620_Human1.02976427
117* EZH2_27294783_Chip-Seq_ESCs_Mouse1.02854846
118* KDM2B_26808549_Chip-Seq_K562_Human1.02781021
119* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02480976
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01651502
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01292972
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01167232
123* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01089422
124NCOR1_26117541_ChIP-Seq_K562_Human1.00975743
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00645279
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00454956
127CTCF_27219007_Chip-Seq_Bcells_Human0.99451008
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98806763
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97106554
130* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96811355
131REST_18959480_ChIP-ChIP_MESCs_Mouse0.96549766
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96486634
133* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91878195
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91679576
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91127757
136UTX_26944678_Chip-Seq_JUKART_Human0.90084610
137RNF2_27304074_Chip-Seq_ESCs_Mouse0.89747748
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88669075
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88582310
140GATA3_26560356_Chip-Seq_TH2_Human0.87467204
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87140874
142RXR_22108803_ChIP-Seq_LS180_Human0.85594932
143* VDR_21846776_ChIP-Seq_THP-1_Human0.85569500
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85391410
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85246635
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84959513
147SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84654073
148* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83864206
149* GATA1_19941827_ChIP-Seq_MEL_Mouse0.78817408
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78073872
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78073872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.71463839
2MP0004510_myositis3.44272410
3MP0009840_abnormal_foam_cell3.11857977
4MP0002148_abnormal_hypersensitivity_rea3.10963170
5MP0009785_altered_susceptibility_to3.08581689
6MP0003436_decreased_susceptibility_to3.06900934
7MP0004858_abnormal_nervous_system2.82428919
8MP0005000_abnormal_immune_tolerance2.50027219
9MP0005671_abnormal_response_to2.46571766
10MP0003724_increased_susceptibility_to2.46206693
11MP0005387_immune_system_phenotype2.36916960
12MP0001790_abnormal_immune_system2.36916960
13MP0002735_abnormal_chemical_nociception2.31048967
14MP0002419_abnormal_innate_immunity2.29166229
15MP0000685_abnormal_immune_system2.29103229
16MP0009046_muscle_twitch2.28692687
17MP0005025_abnormal_response_to2.28217418
18MP0001968_abnormal_touch/_nociception2.21582468
19MP0006082_CNS_inflammation2.17463412
20MP0004859_abnormal_synaptic_plasticity2.17112956
21MP0005058_abnormal_lysosome_morphology2.15994007
22MP0002877_abnormal_melanocyte_morpholog2.13494254
23MP0005451_abnormal_body_composition2.07991683
24MP0002452_abnormal_antigen_presenting1.88247391
25MP0002723_abnormal_immune_serum1.85957223
26MP0003172_abnormal_lysosome_physiology1.85775001
27MP0002736_abnormal_nociception_after1.82167290
28MP0001819_abnormal_immune_cell1.81689408
29MP0002420_abnormal_adaptive_immunity1.78516880
30MP0010386_abnormal_urinary_bladder1.76136879
31MP0005310_abnormal_salivary_gland1.74411801
32MP0002733_abnormal_thermal_nociception1.73989935
33MP0000920_abnormal_myelination1.72098974
34MP0003635_abnormal_synaptic_transmissio1.70951762
35MP0003303_peritoneal_inflammation1.70910088
36MP0003690_abnormal_glial_cell1.69990137
37MP0002405_respiratory_system_inflammati1.69560704
38MP0001800_abnormal_humoral_immune1.63898982
39MP0004782_abnormal_surfactant_physiolog1.63865466
40MP0000343_altered_response_to1.63613660
41MP0008874_decreased_physiological_sensi1.60758075
42MP0005167_abnormal_blood-brain_barrier1.58228754
43MP0001533_abnormal_skeleton_physiology1.53454506
44MP0001970_abnormal_pain_threshold1.52244584
45MP0002734_abnormal_mechanical_nocicepti1.52209857
46MP0006276_abnormal_autonomic_nervous1.52187275
47MP0008569_lethality_at_weaning1.45247174
48MP0003075_altered_response_to1.43938403
49MP0009764_decreased_sensitivity_to1.40161622
50MP0001845_abnormal_inflammatory_respons1.39887428
51MP0002064_seizures1.35356957
52MP0001986_abnormal_taste_sensitivity1.32427465
53MP0005464_abnormal_platelet_physiology1.30686925
54MP0003300_gastrointestinal_ulcer1.29535655
55MP0001501_abnormal_sleep_pattern1.29279088
56MP0003866_abnormal_defecation1.28033992
57MP0003705_abnormal_hypodermis_morpholog1.27089328
58MP0009278_abnormal_bone_marrow1.25030326
59MP0002998_abnormal_bone_remodeling1.24236301
60MP0004270_analgesia1.23643680
61MP0000716_abnormal_immune_system1.22159340
62MP0003448_altered_tumor_morphology1.21599252
63MP0001348_abnormal_lacrimal_gland1.21305963
64MP0005166_decreased_susceptibility_to1.21049781
65MP0003634_abnormal_glial_cell1.20690375
66MP0002184_abnormal_innervation1.20608142
67MP0010155_abnormal_intestine_physiology1.20331293
68MP0003183_abnormal_peptide_metabolism1.20054136
69MP0002067_abnormal_sensory_capabilities1.19362294
70MP0009745_abnormal_behavioral_response1.18526707
71MP0002272_abnormal_nervous_system1.16714522
72MP0002398_abnormal_bone_marrow1.15316268
73MP0005165_increased_susceptibility_to1.13491486
74MP0003880_abnormal_central_pattern1.13409583
75MP0000604_amyloidosis1.12738975
76MP0003091_abnormal_cell_migration1.11928656
77MP0002063_abnormal_learning/memory/cond1.10905311
78MP0003453_abnormal_keratinocyte_physiol1.07231725
79MP0000858_altered_metastatic_potential1.07167747
80MP0002277_abnormal_respiratory_mucosa1.06987628
81MP0004947_skin_inflammation1.06369205
82MP0001440_abnormal_grooming_behavior1.05669311
83MP0005423_abnormal_somatic_nervous1.05156922
84MP0002006_tumorigenesis1.04855167
85MP0003329_amyloid_beta_deposits1.04417528
86MP0003566_abnormal_cell_adhesion1.03712022
87MP0003806_abnormal_nucleotide_metabolis1.00819603
88MP0002572_abnormal_emotion/affect_behav1.00632619
89MP0004883_abnormal_blood_vessel0.98879077
90MP0003123_paternal_imprinting0.97711207
91MP0009333_abnormal_splenocyte_physiolog0.96719494
92MP0000465_gastrointestinal_hemorrhage0.95704611
93MP0002332_abnormal_exercise_endurance0.95671796
94MP0000681_abnormal_thyroid_gland0.95478706
95MP0001545_abnormal_hematopoietic_system0.92851584
96MP0005397_hematopoietic_system_phenotyp0.92851584
97MP0001502_abnormal_circadian_rhythm0.91869352
98MP0005535_abnormal_body_temperature0.91188770
99MP0002138_abnormal_hepatobiliary_system0.90903000
100MP0002429_abnormal_blood_cell0.89833750
101MP0003763_abnormal_thymus_physiology0.89554140
102MP0001849_ear_inflammation0.89057804
103MP0001853_heart_inflammation0.87867707
104MP0005174_abnormal_tail_pigmentation0.87627397
105MP0004742_abnormal_vestibular_system0.87552019
106MP0004811_abnormal_neuron_physiology0.85993743
107MP0005164_abnormal_response_to0.85770305
108MP0004142_abnormal_muscle_tone0.84821729
109MP0008469_abnormal_protein_level0.83850764
110MP0003828_pulmonary_edema0.82243273
111MP0003879_abnormal_hair_cell0.81914544
112MP0002638_abnormal_pupillary_reflex0.81743317
113MP0003633_abnormal_nervous_system0.81710752
114MP0002089_abnormal_postnatal_growth/wei0.80499921
115MP0002166_altered_tumor_susceptibility0.80101167
116MP0008004_abnormal_stomach_pH0.78772769
117MP0003631_nervous_system_phenotype0.78370403
118MP0005023_abnormal_wound_healing0.78092613
119MP0000678_abnormal_parathyroid_gland0.76207897
120MP0003045_fibrosis0.75364009
121MP0002722_abnormal_immune_system0.75324954
122MP0005083_abnormal_biliary_tract0.74859593
123MP0000689_abnormal_spleen_morphology0.74838708
124MP0003191_abnormal_cellular_cholesterol0.74443213
125MP0001958_emphysema0.73792913
126MP0008260_abnormal_autophagy0.73014478
127MP0001851_eye_inflammation0.70066531

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.07764571
2Recurrent abscess formation (HP:0002722)5.93396513
3Recurrent bacterial skin infections (HP:0005406)5.42140677
4Neurofibrillary tangles (HP:0002185)4.41636584
5Recurrent gram-negative bacterial infections (HP:0005420)4.25034039
6Abnormality of macrophages (HP:0004311)4.14431931
7Myositis (HP:0100614)4.09445638
8Elevated erythrocyte sedimentation rate (HP:0003565)3.84954718
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.80028128
10Mediastinal lymphadenopathy (HP:0100721)3.78080173
11Orchitis (HP:0100796)3.69849118
12Cerebral inclusion bodies (HP:0100314)3.69727892
13Increased cerebral lipofuscin (HP:0011813)3.50096502
14Vacuolated lymphocytes (HP:0001922)3.49172221
15Increased IgM level (HP:0003496)3.46999525
16Progressive cerebellar ataxia (HP:0002073)3.41412823
17Neuronal loss in central nervous system (HP:0002529)3.40173051
18Interstitial pulmonary disease (HP:0006530)3.36832083
19Recurrent fungal infections (HP:0002841)3.34984252
20Gingivitis (HP:0000230)3.30914051
21Retrobulbar optic neuritis (HP:0100654)3.27624140
22Optic neuritis (HP:0100653)3.27624140
23Action tremor (HP:0002345)3.25459510
24Recurrent skin infections (HP:0001581)3.21157996
25Myokymia (HP:0002411)3.17670818
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.08749890
27Visual hallucinations (HP:0002367)3.00844770
28Failure to thrive in infancy (HP:0001531)2.99539437
29Obstructive lung disease (HP:0006536)2.98450741
30Chronic obstructive pulmonary disease (HP:0006510)2.98450741
31Autoimmune thrombocytopenia (HP:0001973)2.96398389
32Nuclear cataract (HP:0100018)2.94244225
33Amyloidosis (HP:0011034)2.88165851
34Upper limb amyotrophy (HP:0009129)2.87870462
35Distal upper limb amyotrophy (HP:0007149)2.87870462
36Mutism (HP:0002300)2.81683326
37Abnormality of glycolipid metabolism (HP:0010969)2.73284176
38Abnormality of liposaccharide metabolism (HP:0010968)2.73284176
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.73284176
40Distal lower limb amyotrophy (HP:0008944)2.71412166
41Disinhibition (HP:0000734)2.68146167
42Dysostosis multiplex (HP:0000943)2.64783985
43Supranuclear gaze palsy (HP:0000605)2.63782233
44Annular pancreas (HP:0001734)2.62193359
45Obstructive sleep apnea (HP:0002870)2.55740912
46Atonic seizures (HP:0010819)2.54970187
47Hypothermia (HP:0002045)2.54012212
48Purpura (HP:0000979)2.52876598
49Diminished motivation (HP:0000745)2.44202874
50Loss of speech (HP:0002371)2.43731945
51Basal ganglia calcification (HP:0002135)2.43239097
52Ankle clonus (HP:0011448)2.42042609
53Vasculitis (HP:0002633)2.41592360
54Pustule (HP:0200039)2.39727363
55Recurrent cutaneous fungal infections (HP:0011370)2.38391453
56Chronic mucocutaneous candidiasis (HP:0002728)2.38391453
57Distal lower limb muscle weakness (HP:0009053)2.38091428
58Apathy (HP:0000741)2.37645843
59J-shaped sella turcica (HP:0002680)2.35855092
60Lower limb amyotrophy (HP:0007210)2.34803830
61Achilles tendon contracture (HP:0001771)2.34111246
62Stomatitis (HP:0010280)2.31116573
63Hypercortisolism (HP:0001578)2.29519081
64Spinal canal stenosis (HP:0003416)2.28028623
65Slow saccadic eye movements (HP:0000514)2.24004635
66Febrile seizures (HP:0002373)2.21115370
67Insomnia (HP:0100785)2.20283138
68Recurrent viral infections (HP:0004429)2.20001446
69Systemic lupus erythematosus (HP:0002725)2.19555030
70Petechiae (HP:0000967)2.19374287
71Peripheral hypomyelination (HP:0007182)2.18812694
72Mucopolysacchariduria (HP:0008155)2.18657514
73Urinary glycosaminoglycan excretion (HP:0003541)2.18657514
74Hemoptysis (HP:0002105)2.17041321
75Focal motor seizures (HP:0011153)2.16649363
76Rapidly progressive (HP:0003678)2.16129325
77Upper motor neuron abnormality (HP:0002127)2.14283915
78Abnormality of binocular vision (HP:0011514)2.12188080
79Diplopia (HP:0000651)2.12188080
80Neuroendocrine neoplasm (HP:0100634)2.11715298
81Agitation (HP:0000713)2.10134794
82Abnormal eating behavior (HP:0100738)2.09767186
83Hyperacusis (HP:0010780)2.09311048
84Abnormality of the Achilles tendon (HP:0005109)2.08507560
85Broad face (HP:0000283)2.07417117
86Hypergammaglobulinemia (HP:0010702)2.07407992
87Papilledema (HP:0001085)2.07383313
88Tetraplegia (HP:0002445)2.05963132
89Thyroiditis (HP:0100646)2.05623696
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05187318
91Abnormality of polysaccharide metabolism (HP:0011012)2.05187318
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05187318
93Spontaneous hematomas (HP:0007420)2.04247555
94Urticaria (HP:0001025)2.02892517
95Hepatosplenomegaly (HP:0001433)2.02223925
96Growth hormone excess (HP:0000845)2.01860758
97Dementia (HP:0000726)2.01498973
98Focal seizures (HP:0007359)2.01055527
99Cellulitis (HP:0100658)2.00975220
100Pulmonary infiltrates (HP:0002113)2.00844196
101Abnormality of the vocal cords (HP:0008777)2.00552529
102Severe combined immunodeficiency (HP:0004430)2.00149929
103Rigidity (HP:0002063)1.99934439
104Polyphagia (HP:0002591)1.99921786
105Meningitis (HP:0001287)1.99237310
106Absence seizures (HP:0002121)1.98839374
107Leukocytosis (HP:0001974)1.98241172
108Scanning speech (HP:0002168)1.97513992
109Abnormality of the nasal mucosa (HP:0000433)1.96879927
110Progressive inability to walk (HP:0002505)1.96393370
111Inappropriate behavior (HP:0000719)1.95270092
112Pheochromocytoma (HP:0002666)1.94691463
113Arterial thrombosis (HP:0004420)1.93314869
114Truncal ataxia (HP:0002078)1.92060454
115Tetraparesis (HP:0002273)1.91657703
116Axonal loss (HP:0003447)1.91460369
117Abnormal gallbladder physiology (HP:0012438)1.91420638
118Cholecystitis (HP:0001082)1.91420638
119Poor head control (HP:0002421)1.91185734
120Abnormal hair whorl (HP:0010721)1.90583001
121Periodontitis (HP:0000704)1.90145911
122Cerebral hemorrhage (HP:0001342)1.90132999
123Menstrual irregularities (HP:0000858)1.90129884
124Difficulty climbing stairs (HP:0003551)1.88623108
125Abnormality of T cell number (HP:0011839)1.88271247
126Prolonged neonatal jaundice (HP:0006579)1.87868581
127Delusions (HP:0000746)1.87199421
128Hyperparathyroidism (HP:0000843)1.84927741
129Polygenic inheritance (HP:0010982)1.84848937
130Depression (HP:0000716)1.84806636
131Cerebral aneurysm (HP:0004944)1.83740137
132Spastic gait (HP:0002064)1.83485767
133Prolonged bleeding time (HP:0003010)1.83195730
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.82497246
135Combined immunodeficiency (HP:0005387)1.82486905
136Decreased motor nerve conduction velocity (HP:0003431)1.81622954
137Segmental peripheral demyelination/remyelination (HP:0003481)1.81408312
138Hand muscle atrophy (HP:0009130)1.81242675
139Epistaxis (HP:0000421)1.81181499
140Ocular albinism (HP:0001107)1.77971527
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77850654
142Vertebral compression fractures (HP:0002953)1.77200357
143Increased serum ferritin (HP:0003281)1.76589083
144Onion bulb formation (HP:0003383)1.76582411
145Global brain atrophy (HP:0002283)1.75786118
146Distal sensory impairment (HP:0002936)1.75677371
147Foot dorsiflexor weakness (HP:0009027)1.75312750
148Hypertensive crisis (HP:0100735)1.74940612
149Hemiplegia (HP:0002301)1.73869431
150Esophageal neoplasm (HP:0100751)1.73513784
151Neoplasm of head and neck (HP:0012288)1.73513784
152Prostate neoplasm (HP:0100787)1.73206846
153Dysmetria (HP:0001310)1.73201258
154Hemorrhage of the eye (HP:0011885)1.72498398
155Psychosis (HP:0000709)1.70719184
156Horizontal nystagmus (HP:0000666)1.70460959
157Increased connective tissue (HP:0009025)1.70444109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.03858115
2RIPK43.57124461
3ARAF3.24066650
4IRAK33.15417227
5MAP3K142.67842808
6NME22.53746719
7CAMKK22.44793856
8PIM22.42351916
9TESK22.26425539
10TBK12.22693197
11TRIB32.14979911
12MAP3K92.08040407
13MAP3K132.07717260
14KSR21.99567607
15EPHA21.97743497
16LMTK21.85800429
17TAOK21.81981021
18IRAK41.79790343
19BLK1.76048464
20RIPK11.72665695
21MATK1.72602778
22ERBB31.72126817
23EPHA41.70433670
24SIK31.69827328
25MINK11.67490851
26JAK31.61673689
27TYK21.60584583
28MAP4K11.60579389
29ZAP701.58207833
30IKBKE1.55251985
31TXK1.48261241
32MST1R1.46817638
33KIT1.39284437
34SIK11.38342868
35CAMKK11.33241208
36ICK1.31696957
37NTRK11.31211851
38ERN11.29988790
39MAP3K31.29168109
40DAPK21.27673977
41NTRK31.27604432
42BMPR21.25639028
43MAP3K111.21943564
44NEK91.17372767
45SCYL21.17098477
46DAPK11.11944931
47TESK11.11259283
48GRK51.10507089
49JAK11.08946069
50EPHB11.08204587
51LIMK11.04876284
52PRKD31.04388315
53MAP3K11.02582170
54PDPK11.01381709
55IRAK21.01322755
56MARK20.99228737
57STK380.98458048
58SYK0.96697866
59IKBKB0.96455633
60MAP3K20.96146079
61RAF10.95980994
62MYLK0.95737659
63PRKD20.95402716
64CSK0.95018245
65ADRBK20.94293432
66BTK0.91499303
67TAOK10.89557686
68RPS6KA20.86624893
69MST40.85988399
70RET0.83661211
71PRKCH0.83376787
72GRK70.82181031
73PDK10.81490911
74MOS0.81070806
75PTK60.79975246
76MAPK120.79860021
77LCK0.75207484
78PAK40.74884565
79TEC0.73137545
80TTN0.72409653
81PTK20.72024676
82BRAF0.71561266
83FES0.71542011
84MAP2K40.71417864
85ITK0.70563701
86BMX0.70308801
87JAK20.70293900
88TGFBR20.69631755
89PAK60.69521994
90CDK190.69200698
91HCK0.68941389
92GRK60.68633016
93SMG10.66114441
94PRKG20.65212926
95CHUK0.65022500
96CDK150.62820421
97CDK140.62800542
98PRPF4B0.62557784
99MAP2K70.62312414
100NTRK20.60995830
101ABL20.60695045
102CDK11A0.59832994
103LATS20.59755920
104CDK180.59234607
105UHMK10.59025676
106DAPK30.58832924
107CAMK2B0.58031508
108BCR0.57899690
109TNK20.57553479
110MAP3K50.56238889
111CAMK2G0.55658159
112YES10.55307846
113CDC42BPA0.54250090
114PRKCD0.54183612
115PLK20.52062513
116CDK50.51011700
117PHKG20.50673790
118PHKG10.50673790
119KSR10.50127862
120FGR0.49659957
121RPS6KA60.49327142
122ERBB40.49216573
123BCKDK0.49176723
124ILK0.48116042
125MAPK110.45216747
126MAP2K60.44844262
127MAP2K10.44700140
128HIPK20.44595445
129FYN0.44465460
130PAK10.43480544
131LRRK20.42860999
132ADRBK10.42414734
133MET0.41765665
134FGFR30.41490301
135DYRK1B0.41339513
136SIK20.41230422
137CAMK10.41082668
138CSF1R0.40740023
139RPS6KL10.40699603
140RPS6KC10.40699603
141PIM10.40532607
142WNK10.40468435
143KDR0.40252915
144MAP2K30.40168635
145LYN0.39176469
146MARK30.38383473

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.48809078
2Leishmaniasis_Homo sapiens_hsa051402.16847409
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00213977
4Collecting duct acid secretion_Homo sapiens_hsa049661.91322559
5Rheumatoid arthritis_Homo sapiens_hsa053231.90783772
6Graft-versus-host disease_Homo sapiens_hsa053321.77670503
7Phagosome_Homo sapiens_hsa041451.62857310
8Osteoclast differentiation_Homo sapiens_hsa043801.59691962
9Tuberculosis_Homo sapiens_hsa051521.56715590
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53654478
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53391328
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52236106
13Lysosome_Homo sapiens_hsa041421.51016877
14Pertussis_Homo sapiens_hsa051331.46277863
15Salmonella infection_Homo sapiens_hsa051321.44532169
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44526029
17Shigellosis_Homo sapiens_hsa051311.41330066
18Allograft rejection_Homo sapiens_hsa053301.41123185
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39343388
20Chemokine signaling pathway_Homo sapiens_hsa040621.38238349
21Vibrio cholerae infection_Homo sapiens_hsa051101.37368371
22Nicotine addiction_Homo sapiens_hsa050331.36483516
23Prion diseases_Homo sapiens_hsa050201.28808096
24Long-term depression_Homo sapiens_hsa047301.25735281
25Pentose phosphate pathway_Homo sapiens_hsa000301.23896457
26Long-term potentiation_Homo sapiens_hsa047201.23206356
27Legionellosis_Homo sapiens_hsa051341.22471961
28Olfactory transduction_Homo sapiens_hsa047401.22027747
29Type I diabetes mellitus_Homo sapiens_hsa049401.21661048
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19195208
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15609183
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15030482
33TNF signaling pathway_Homo sapiens_hsa046681.13309529
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12029265
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10896523
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10703757
37Toxoplasmosis_Homo sapiens_hsa051451.10191270
38Measles_Homo sapiens_hsa051621.09592877
39Glutamatergic synapse_Homo sapiens_hsa047241.08447814
40Fructose and mannose metabolism_Homo sapiens_hsa000511.08356157
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07593432
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.07483432
43Influenza A_Homo sapiens_hsa051641.06749862
44GABAergic synapse_Homo sapiens_hsa047271.06591824
45Circadian entrainment_Homo sapiens_hsa047131.06159464
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05749628
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04945221
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04582772
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04162663
50Morphine addiction_Homo sapiens_hsa050321.04113359
51Asthma_Homo sapiens_hsa053101.03882654
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03366402
53Cholinergic synapse_Homo sapiens_hsa047251.02546884
54Gastric acid secretion_Homo sapiens_hsa049711.01936977
55Apoptosis_Homo sapiens_hsa042101.01610675
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.01128949
57Malaria_Homo sapiens_hsa051441.00913590
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00913314
59Taste transduction_Homo sapiens_hsa047421.00046353
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.98629340
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98408754
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.95271671
63Glioma_Homo sapiens_hsa052140.93336956
64Dopaminergic synapse_Homo sapiens_hsa047280.92360878
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91677367
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91124390
67Salivary secretion_Homo sapiens_hsa049700.90296261
68Galactose metabolism_Homo sapiens_hsa000520.89645396
69Serotonergic synapse_Homo sapiens_hsa047260.89409619
70Prolactin signaling pathway_Homo sapiens_hsa049170.88326574
71Chronic myeloid leukemia_Homo sapiens_hsa052200.88293816
72ErbB signaling pathway_Homo sapiens_hsa040120.87156533
73Staphylococcus aureus infection_Homo sapiens_hsa051500.85163201
74T cell receptor signaling pathway_Homo sapiens_hsa046600.84685242
75Non-small cell lung cancer_Homo sapiens_hsa052230.84308569
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.83479786
77VEGF signaling pathway_Homo sapiens_hsa043700.83232693
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.82984182
79B cell receptor signaling pathway_Homo sapiens_hsa046620.81985907
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80792847
81African trypanosomiasis_Homo sapiens_hsa051430.79689611
82Viral myocarditis_Homo sapiens_hsa054160.78284482
83GnRH signaling pathway_Homo sapiens_hsa049120.76759493
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75539435
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.74745135
86Bladder cancer_Homo sapiens_hsa052190.74070895
87Platelet activation_Homo sapiens_hsa046110.73885375
88Antigen processing and presentation_Homo sapiens_hsa046120.73125794
89Endocytosis_Homo sapiens_hsa041440.72926479
90Hematopoietic cell lineage_Homo sapiens_hsa046400.71796925
91Hepatitis B_Homo sapiens_hsa051610.71648622
92Autoimmune thyroid disease_Homo sapiens_hsa053200.71588637
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70899773
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.70129286
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.69790349
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69301334
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69272619
98Renin secretion_Homo sapiens_hsa049240.68927997
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68571037
100Estrogen signaling pathway_Homo sapiens_hsa049150.66365804
101Primary immunodeficiency_Homo sapiens_hsa053400.66176006
102Acute myeloid leukemia_Homo sapiens_hsa052210.66092023
103Hepatitis C_Homo sapiens_hsa051600.66025763
104Pancreatic cancer_Homo sapiens_hsa052120.65741807
105Other glycan degradation_Homo sapiens_hsa005110.65726085
106Amoebiasis_Homo sapiens_hsa051460.65607575
107Renal cell carcinoma_Homo sapiens_hsa052110.65474332
108Vitamin B6 metabolism_Homo sapiens_hsa007500.65307710
109Pancreatic secretion_Homo sapiens_hsa049720.65064466
110HIF-1 signaling pathway_Homo sapiens_hsa040660.64729892
111Insulin secretion_Homo sapiens_hsa049110.64632437
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60614270
113Cocaine addiction_Homo sapiens_hsa050300.60556448
114Type II diabetes mellitus_Homo sapiens_hsa049300.59963131
115Gap junction_Homo sapiens_hsa045400.59625492
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59567116
117Dorso-ventral axis formation_Homo sapiens_hsa043200.59238032
118Mineral absorption_Homo sapiens_hsa049780.59070501
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58599768
120Calcium signaling pathway_Homo sapiens_hsa040200.58155480
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57457209
122Amphetamine addiction_Homo sapiens_hsa050310.56354064
123MAPK signaling pathway_Homo sapiens_hsa040100.55731939
124Inositol phosphate metabolism_Homo sapiens_hsa005620.55470342
125Oxytocin signaling pathway_Homo sapiens_hsa049210.54946147
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54717031
127Rap1 signaling pathway_Homo sapiens_hsa040150.53880542

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