HPCAL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.86712837
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.82704068
3locomotory exploration behavior (GO:0035641)6.43897486
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.34027808
5synaptic vesicle exocytosis (GO:0016079)5.96731008
6glutamate secretion (GO:0014047)5.91961347
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.91276210
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68648758
9vocalization behavior (GO:0071625)5.64348541
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54730575
11regulation of synaptic vesicle exocytosis (GO:2000300)5.45497241
12regulation of glutamate receptor signaling pathway (GO:1900449)5.35161300
13regulation of neuronal synaptic plasticity (GO:0048168)5.10643785
14regulation of long-term neuronal synaptic plasticity (GO:0048169)5.01560441
15regulation of synaptic vesicle transport (GO:1902803)4.91874025
16protein localization to synapse (GO:0035418)4.88262485
17exploration behavior (GO:0035640)4.83935455
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.82425348
19cerebellar granule cell differentiation (GO:0021707)4.79368490
20neurotransmitter secretion (GO:0007269)4.65451443
21regulation of synapse structural plasticity (GO:0051823)4.63071732
22neuronal action potential propagation (GO:0019227)4.61827352
23amino acid import (GO:0043090)4.52967060
24dendritic spine morphogenesis (GO:0060997)4.44399504
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43827571
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38542203
27synaptic transmission, glutamatergic (GO:0035249)4.38342147
28long-term memory (GO:0007616)4.27083700
29neurotransmitter-gated ion channel clustering (GO:0072578)4.24568542
30positive regulation of membrane potential (GO:0045838)4.24053401
31potassium ion homeostasis (GO:0055075)4.22773525
32layer formation in cerebral cortex (GO:0021819)4.20323992
33postsynaptic membrane organization (GO:0001941)4.19725832
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.18618487
35glutamate receptor signaling pathway (GO:0007215)4.15203963
36neuron-neuron synaptic transmission (GO:0007270)4.07892739
37regulation of synaptic plasticity (GO:0048167)4.05257597
38neuron cell-cell adhesion (GO:0007158)4.05174427
39proline transport (GO:0015824)4.04460825
40regulation of dendritic spine morphogenesis (GO:0061001)4.02741417
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97863018
42regulation of postsynaptic membrane potential (GO:0060078)3.92908243
43potassium ion import (GO:0010107)3.92196413
44cellular potassium ion homeostasis (GO:0030007)3.86744898
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.86245511
46central nervous system myelination (GO:0022010)3.80798469
47axon ensheathment in central nervous system (GO:0032291)3.80798469
48regulation of synapse maturation (GO:0090128)3.79728004
49long-term synaptic potentiation (GO:0060291)3.77638713
50activation of protein kinase A activity (GO:0034199)3.73975966
51positive regulation of neurotransmitter secretion (GO:0001956)3.73137718
52neurotransmitter transport (GO:0006836)3.70819060
53regulation of neurotransmitter secretion (GO:0046928)3.68408052
54negative regulation of dendrite morphogenesis (GO:0050774)3.67996300
55gamma-aminobutyric acid transport (GO:0015812)3.64431571
56neuromuscular process controlling balance (GO:0050885)3.63392311
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.63250795
58positive regulation of neurotransmitter transport (GO:0051590)3.62500073
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.61991685
60synaptic vesicle endocytosis (GO:0048488)3.58981202
61sodium ion export (GO:0071436)3.58843444
62cellular sodium ion homeostasis (GO:0006883)3.58004485
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53853575
64regulation of neurotransmitter levels (GO:0001505)3.46958091
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.45794458
66L-amino acid import (GO:0043092)3.44720428
67dendritic spine organization (GO:0097061)3.44383303
68acidic amino acid transport (GO:0015800)3.43006276
69regulation of neurotransmitter transport (GO:0051588)3.41880912
70regulation of vesicle fusion (GO:0031338)3.39767412
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39634453
72neurotransmitter uptake (GO:0001504)3.39587521
73regulation of dendritic spine development (GO:0060998)3.38971668
74positive regulation of synapse maturation (GO:0090129)3.37046885
75prepulse inhibition (GO:0060134)3.36282192
76transmission of nerve impulse (GO:0019226)3.35950280
77establishment of synaptic vesicle localization (GO:0097480)3.31376176
78synaptic vesicle transport (GO:0048489)3.31376176
79chemosensory behavior (GO:0007635)3.28693598
80positive regulation of synaptic transmission (GO:0050806)3.27215754
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.26518269
82membrane depolarization (GO:0051899)3.25155678
83neuromuscular process controlling posture (GO:0050884)3.24679841
84auditory behavior (GO:0031223)3.23849566
85neuromuscular synaptic transmission (GO:0007274)3.23388800
86regulation of ARF protein signal transduction (GO:0032012)3.22877347
87neuron recognition (GO:0008038)3.22634944
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22235769
89vesicle docking involved in exocytosis (GO:0006904)3.22095912
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21158108
91positive regulation of dendritic spine development (GO:0060999)3.20948973
92behavioral defense response (GO:0002209)3.20658063
93behavioral fear response (GO:0001662)3.20658063
94response to auditory stimulus (GO:0010996)3.19578280
95regulation of synaptic transmission (GO:0050804)3.19575337
96vesicle transport along microtubule (GO:0047496)3.18577367
97learning (GO:0007612)3.16631036
98neuronal ion channel clustering (GO:0045161)3.15998994
99membrane hyperpolarization (GO:0060081)3.15617082
100response to histamine (GO:0034776)3.15128272
101glycine transport (GO:0015816)3.13697471
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13090012
103establishment of mitochondrion localization (GO:0051654)3.08093855
104presynaptic membrane organization (GO:0097090)3.07904870
105cell communication by electrical coupling (GO:0010644)3.06984027
106innervation (GO:0060384)3.06805649
107synaptic transmission (GO:0007268)3.05481189
108cell differentiation in hindbrain (GO:0021533)3.04757957
109presynaptic membrane assembly (GO:0097105)3.04694799
110detection of calcium ion (GO:0005513)3.04578698
111cell communication involved in cardiac conduction (GO:0086065)3.04135714
112signal release (GO:0023061)3.03914503
113social behavior (GO:0035176)3.03646252
114intraspecies interaction between organisms (GO:0051703)3.03646252
115cerebellar Purkinje cell differentiation (GO:0021702)3.03265956
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03192528
117regulation of voltage-gated calcium channel activity (GO:1901385)3.03149692
118regulation of glutamate secretion (GO:0014048)3.03062671
119negative regulation of amino acid transport (GO:0051956)2.99902564
120regulation of female receptivity (GO:0045924)2.99392670
121neuromuscular process (GO:0050905)2.98753533
122long term synaptic depression (GO:0060292)2.98685213
123axonal fasciculation (GO:0007413)2.98565180
124membrane depolarization during action potential (GO:0086010)2.98554909
125dendrite morphogenesis (GO:0048813)2.97983601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34228117
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20941102
3GBX2_23144817_ChIP-Seq_PC3_Human3.20026514
4RARB_27405468_Chip-Seq_BRAIN_Mouse3.12997405
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11337588
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10835525
7REST_21632747_ChIP-Seq_MESCs_Mouse2.88283584
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76957706
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76957706
10DROSHA_22980978_ChIP-Seq_HELA_Human2.76548642
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72777139
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65630239
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62055856
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60876361
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50193060
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47228618
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.44736637
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.37568010
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35031943
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34073604
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31157101
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.25339039
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.23943784
24* EED_16625203_ChIP-ChIP_MESCs_Mouse2.13642629
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07986870
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98211794
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85859765
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85194742
29AR_21572438_ChIP-Seq_LNCaP_Human1.85066861
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.77818530
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59645484
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57519410
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57063774
34SMAD4_21799915_ChIP-Seq_A2780_Human1.53563613
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45274320
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42637760
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42485167
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.35761824
39TAF15_26573619_Chip-Seq_HEK293_Human1.33882148
40SOX2_21211035_ChIP-Seq_LN229_Gbm1.27985131
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27188163
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27068564
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25283266
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.23672457
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.22312965
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21041515
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20622763
48KDM2B_26808549_Chip-Seq_K562_Human1.20420057
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20094650
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.19949083
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19673947
52* AR_19668381_ChIP-Seq_PC3_Human1.19618802
53AR_25329375_ChIP-Seq_VCAP_Human1.17554920
54* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17317545
55P300_19829295_ChIP-Seq_ESCs_Human1.17294756
56ZNF274_21170338_ChIP-Seq_K562_Hela1.16947099
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15036933
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14694479
59* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12609333
60STAT3_23295773_ChIP-Seq_U87_Human1.10678943
61* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10675226
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.09712608
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09676796
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08086755
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07836571
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07682960
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06018093
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05657797
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04915577
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03083645
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02522554
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01896345
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99446903
74TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99291828
75SMAD3_21741376_ChIP-Seq_HESCs_Human0.98794747
76TCF4_23295773_ChIP-Seq_U87_Human0.98699550
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98489673
78YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98311535
79RXR_22108803_ChIP-Seq_LS180_Human0.97769738
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97695194
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97153149
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96610376
83TP53_16413492_ChIP-PET_HCT116_Human0.95997522
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.94731643
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93503828
86PRDM14_20953172_ChIP-Seq_ESCs_Human0.92484627
87OCT4_19829295_ChIP-Seq_ESCs_Human0.92089006
88CBX2_27304074_Chip-Seq_ESCs_Mouse0.91754237
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91092761
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.91067779
91CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90971734
92DPY_21335234_ChIP-Seq_ESCs_Mouse0.90916424
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90572219
94AHR_22903824_ChIP-Seq_MCF-7_Human0.90244071
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90099088
96CTCF_27219007_Chip-Seq_Bcells_Human0.90003916
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89841604
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89672328
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.89620850
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88449983
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88340047
102* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88283813
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88256270
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.88237156
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85193725
106RUNX2_22187159_ChIP-Seq_PCA_Human0.84957276
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82839555
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82208236
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82163269
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80546111
111RNF2_27304074_Chip-Seq_NSC_Mouse0.79999541
112LXR_22292898_ChIP-Seq_THP-1_Human0.79667522
113EGR1_19032775_ChIP-ChIP_M12_Human0.79199140
114KLF4_19829295_ChIP-Seq_ESCs_Human0.79158954
115JUN_21703547_ChIP-Seq_K562_Human0.78927887
116SMC4_20622854_ChIP-Seq_HELA_Human0.78188181
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77659630
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.77289457
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77144478
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77039628
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75994486
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74261674
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72965784
124SOX9_26525672_Chip-Seq_HEART_Mouse0.72558729
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71920104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.73770414
2MP0003880_abnormal_central_pattern4.91751606
3MP0003635_abnormal_synaptic_transmissio4.50814311
4MP0004270_analgesia3.98622115
5MP0002822_catalepsy3.77805974
6MP0009745_abnormal_behavioral_response3.67535494
7MP0002063_abnormal_learning/memory/cond3.64471885
8MP0002064_seizures3.38257616
9MP0001968_abnormal_touch/_nociception3.02197840
10MP0009046_muscle_twitch2.94423836
11MP0002572_abnormal_emotion/affect_behav2.94263419
12MP0001486_abnormal_startle_reflex2.69462438
13MP0005423_abnormal_somatic_nervous2.61969185
14MP0002272_abnormal_nervous_system2.61026505
15MP0002734_abnormal_mechanical_nocicepti2.54581909
16MP0001501_abnormal_sleep_pattern2.39230024
17MP0002736_abnormal_nociception_after2.22196914
18MP0009780_abnormal_chondrocyte_physiolo2.09801984
19MP0001440_abnormal_grooming_behavior2.07302794
20MP0008569_lethality_at_weaning1.94604377
21MP0001970_abnormal_pain_threshold1.87782658
22MP0002735_abnormal_chemical_nociception1.84542154
23MP0004811_abnormal_neuron_physiology1.84414583
24MP0002733_abnormal_thermal_nociception1.83618840
25MP0003329_amyloid_beta_deposits1.82378831
26MP0004858_abnormal_nervous_system1.82282069
27MP0002067_abnormal_sensory_capabilities1.76263592
28MP0002909_abnormal_adrenal_gland1.75858757
29MP0003879_abnormal_hair_cell1.74251049
30MP0005646_abnormal_pituitary_gland1.73087751
31MP0005386_behavior/neurological_phenoty1.68610965
32MP0004924_abnormal_behavior1.68610965
33MP0002557_abnormal_social/conspecific_i1.68489806
34MP0002184_abnormal_innervation1.51277480
35MP0003633_abnormal_nervous_system1.47238275
36MP0000778_abnormal_nervous_system1.46466663
37MP0004885_abnormal_endolymph1.43579458
38MP0000955_abnormal_spinal_cord1.41096766
39MP0001984_abnormal_olfaction1.40833826
40MP0002066_abnormal_motor_capabilities/c1.39757667
41MP0003075_altered_response_to1.39583243
42MP0003787_abnormal_imprinting1.36333514
43MP0002882_abnormal_neuron_morphology1.33179792
44MP0001905_abnormal_dopamine_level1.28687723
45MP0001529_abnormal_vocalization1.27457768
46MP0003631_nervous_system_phenotype1.20432210
47MP0003123_paternal_imprinting1.19863102
48MP0001502_abnormal_circadian_rhythm1.18039770
49MP0008872_abnormal_physiological_respon1.17065239
50MP0005645_abnormal_hypothalamus_physiol1.13462944
51MP0008874_decreased_physiological_sensi1.08980722
52MP0006276_abnormal_autonomic_nervous1.08183328
53MP0008961_abnormal_basal_metabolism1.06329535
54MP0001177_atelectasis1.05508830
55MP0010234_abnormal_vibrissa_follicle1.05030263
56MP0002152_abnormal_brain_morphology1.02813173
57MP0000751_myopathy0.98558659
58MP0002069_abnormal_eating/drinking_beha0.98296693
59MP0004142_abnormal_muscle_tone0.97784438
60MP0005167_abnormal_blood-brain_barrier0.96944071
61MP0000569_abnormal_digit_pigmentation0.95574952
62MP0003690_abnormal_glial_cell0.94775506
63MP0005535_abnormal_body_temperature0.93778906
64MP0002638_abnormal_pupillary_reflex0.92578082
65MP0003122_maternal_imprinting0.91880860
66MP0001986_abnormal_taste_sensitivity0.89450983
67MP0004147_increased_porphyrin_level0.88430324
68MP0002090_abnormal_vision0.85055494
69MP0003283_abnormal_digestive_organ0.84450316
70MP0000013_abnormal_adipose_tissue0.84208693
71MP0000604_amyloidosis0.84162917
72MP0002229_neurodegeneration0.83471055
73MP0004510_myositis0.83044931
74MP0004085_abnormal_heartbeat0.80552228
75MP0001346_abnormal_lacrimal_gland0.79396065
76MP0000920_abnormal_myelination0.79090209
77MP0010386_abnormal_urinary_bladder0.78739763
78MP0008877_abnormal_DNA_methylation0.75836759
79MP0005551_abnormal_eye_electrophysiolog0.75790526
80MP0003632_abnormal_nervous_system0.74736099
81MP0001188_hyperpigmentation0.73752716
82MP0001348_abnormal_lacrimal_gland0.73433133
83MP0003121_genomic_imprinting0.72895269
84MP0003634_abnormal_glial_cell0.71903246
85MP0005394_taste/olfaction_phenotype0.70332011
86MP0005499_abnormal_olfactory_system0.70332011
87MP0001963_abnormal_hearing_physiology0.69759671
88MP0001664_abnormal_digestion0.67049800
89MP0003172_abnormal_lysosome_physiology0.66889296
90MP0004484_altered_response_of0.64395616
91MP0004145_abnormal_muscle_electrophysio0.63931414
92MP0005623_abnormal_meninges_morphology0.62056247
93MP0005409_darkened_coat_color0.61769378
94MP0004215_abnormal_myocardial_fiber0.61491508
95MP0005166_decreased_susceptibility_to0.59985886
96MP0004742_abnormal_vestibular_system0.59795935
97MP0002837_dystrophic_cardiac_calcinosis0.57336805
98MP0000631_abnormal_neuroendocrine_gland0.56137986
99MP0001485_abnormal_pinna_reflex0.55403437
100MP0010768_mortality/aging0.54762620
101MP0002752_abnormal_somatic_nervous0.54718291
102MP0004043_abnormal_pH_regulation0.53787589
103MP0002082_postnatal_lethality0.53528023
104MP0010770_preweaning_lethality0.53528023
105MP0004233_abnormal_muscle_weight0.51987863
106MP0003137_abnormal_impulse_conducting0.51614862
107MP0003956_abnormal_body_size0.49002634
108MP0001943_abnormal_respiration0.48973069
109MP0002876_abnormal_thyroid_physiology0.48572650
110MP0010769_abnormal_survival0.48521623
111MP0004130_abnormal_muscle_cell0.48073654
112MP0000026_abnormal_inner_ear0.47966875
113MP0003861_abnormal_nervous_system0.47870192
114MP0000639_abnormal_adrenal_gland0.45383089
115MP0002873_normal_phenotype0.44612065
116MP0000579_abnormal_nail_morphology0.44157987
117MP0002169_no_abnormal_phenotype0.43068549

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.43206060
2Myokymia (HP:0002411)8.35523313
3Focal seizures (HP:0007359)6.19942142
4Visual hallucinations (HP:0002367)5.62387465
5Epileptic encephalopathy (HP:0200134)4.98294346
6Atonic seizures (HP:0010819)4.51980825
7Febrile seizures (HP:0002373)4.46003731
8Absence seizures (HP:0002121)4.27400664
9Progressive cerebellar ataxia (HP:0002073)4.18855174
10Generalized tonic-clonic seizures (HP:0002069)4.14707233
11Action tremor (HP:0002345)4.03899095
12Impaired vibration sensation in the lower limbs (HP:0002166)4.01385001
13Dialeptic seizures (HP:0011146)3.96419803
14Papilledema (HP:0001085)3.86665070
15Ankle clonus (HP:0011448)3.75839844
16Poor eye contact (HP:0000817)3.71811976
17Depression (HP:0000716)3.65070057
18Broad-based gait (HP:0002136)3.52078800
19Gaze-evoked nystagmus (HP:0000640)3.49420201
20Urinary bladder sphincter dysfunction (HP:0002839)3.44661472
21Postural instability (HP:0002172)3.42888044
22Cerebral hypomyelination (HP:0006808)3.39818732
23Supranuclear gaze palsy (HP:0000605)3.39675041
24Dysmetria (HP:0001310)3.36387329
25Dysdiadochokinesis (HP:0002075)3.36144617
26Anxiety (HP:0000739)3.36084174
27Impaired social interactions (HP:0000735)3.31611977
28Abnormal social behavior (HP:0012433)3.31611977
29Tetraplegia (HP:0002445)3.21137092
30Amblyopia (HP:0000646)3.15330693
31Abnormality of the lower motor neuron (HP:0002366)3.05544536
32Torticollis (HP:0000473)3.02323792
33Truncal ataxia (HP:0002078)3.02020373
34Akinesia (HP:0002304)3.01939628
35Abnormal eating behavior (HP:0100738)3.00405010
36Urinary urgency (HP:0000012)2.96075747
37Hyperventilation (HP:0002883)2.94954834
38Focal dystonia (HP:0004373)2.92666717
39Annular pancreas (HP:0001734)2.91996988
40Mutism (HP:0002300)2.91239024
41Impaired smooth pursuit (HP:0007772)2.86649375
42Peripheral hypomyelination (HP:0007182)2.80274276
43Bradykinesia (HP:0002067)2.75520943
44Stereotypic behavior (HP:0000733)2.74668006
45Impaired vibratory sensation (HP:0002495)2.73601444
46Ventricular fibrillation (HP:0001663)2.73357722
47Sleep apnea (HP:0010535)2.72968133
48Intention tremor (HP:0002080)2.69397595
49Spastic gait (HP:0002064)2.67866493
50Genetic anticipation (HP:0003743)2.62643287
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57869338
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.57869338
53Hemiplegia (HP:0002301)2.54649872
54Dysmetric saccades (HP:0000641)2.53364936
55Megalencephaly (HP:0001355)2.51603823
56Craniofacial dystonia (HP:0012179)2.51446523
57Scanning speech (HP:0002168)2.50872588
58Progressive inability to walk (HP:0002505)2.49118455
59Abnormality of ocular smooth pursuit (HP:0000617)2.48660095
60Cerebral inclusion bodies (HP:0100314)2.40578898
61Hemiparesis (HP:0001269)2.40281755
62Status epilepticus (HP:0002133)2.39579245
63Drooling (HP:0002307)2.38848839
64Excessive salivation (HP:0003781)2.38848839
65Pointed chin (HP:0000307)2.36050654
66Neurofibrillary tangles (HP:0002185)2.35392208
67Diminished motivation (HP:0000745)2.35270185
68Epileptiform EEG discharges (HP:0011182)2.34546582
69Diplopia (HP:0000651)2.33377645
70Abnormality of binocular vision (HP:0011514)2.33377645
71Bundle branch block (HP:0011710)2.32049437
72Generalized myoclonic seizures (HP:0002123)2.29973311
73Morphological abnormality of the pyramidal tract (HP:0002062)2.27578601
74Ankyloglossia (HP:0010296)2.27104026
75Fetal akinesia sequence (HP:0001989)2.25902578
76Spastic tetraparesis (HP:0001285)2.24087402
77Resting tremor (HP:0002322)2.23913890
78EEG with generalized epileptiform discharges (HP:0011198)2.23752283
79Absent speech (HP:0001344)2.22321157
80Lower limb muscle weakness (HP:0007340)2.21122285
81CNS hypomyelination (HP:0003429)2.19266145
82Choreoathetosis (HP:0001266)2.18759029
83Termporal pattern (HP:0011008)2.16371652
84Insidious onset (HP:0003587)2.16371652
85Incomplete penetrance (HP:0003829)2.15581620
86Obstructive sleep apnea (HP:0002870)2.15139605
87Hypsarrhythmia (HP:0002521)2.13813781
88Split foot (HP:0001839)2.10485463
89Delusions (HP:0000746)2.09913009
90Amyotrophic lateral sclerosis (HP:0007354)2.09686837
91Insomnia (HP:0100785)2.03772430
92Inability to walk (HP:0002540)2.03676033
93Gait ataxia (HP:0002066)2.02194124
94Clonus (HP:0002169)2.00108328
95Lower limb amyotrophy (HP:0007210)1.97938418
96Abnormality of the periventricular white matter (HP:0002518)1.96522244
97Rigidity (HP:0002063)1.96418907
98Abnormal EKG (HP:0003115)1.94306179
99Lower limb asymmetry (HP:0100559)1.91230732
100Abnormality of saccadic eye movements (HP:0000570)1.90996686
101Rapidly progressive (HP:0003678)1.90356474
102Pheochromocytoma (HP:0002666)1.85170593
103Neuronal loss in central nervous system (HP:0002529)1.84287536
104Spastic tetraplegia (HP:0002510)1.82995676
105Increased circulating renin level (HP:0000848)1.81531542
106Memory impairment (HP:0002354)1.80229383
107Blue irides (HP:0000635)1.79920398
108Limb dystonia (HP:0002451)1.77892947
109Psychosis (HP:0000709)1.77283965
110Intellectual disability, profound (HP:0002187)1.76243570
111Polyphagia (HP:0002591)1.74437358
112Abnormality of the corticospinal tract (HP:0002492)1.74050748
113Paraplegia (HP:0010550)1.73050175
114Agitation (HP:0000713)1.69960564
115Spinal canal stenosis (HP:0003416)1.66702156
116Abnormality of oral frenula (HP:0000190)1.65211253
117Abnormality of salivation (HP:0100755)1.63779327
118Apathy (HP:0000741)1.63592916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.25222204
2NTRK34.52418321
3MAP3K94.22267282
4DAPK23.07454284
5MAP3K42.72715249
6PRKD32.71472923
7KSR22.69751636
8MINK12.53811300
9PAK62.41608595
10MAP2K72.24026362
11RIPK42.13155435
12CAMKK12.11299156
13MARK12.00736149
14MAP3K121.92277008
15DAPK11.90712782
16ARAF1.87764538
17MAP3K131.82383338
18MAP2K41.80976240
19KSR11.80413926
20NTRK21.79907855
21NTRK11.76624303
22CDK191.61928839
23CDK51.60453274
24PRPF4B1.47325134
25STK381.45481126
26MAP3K21.42701877
27FES1.37100114
28PLK21.34788504
29TNIK1.32407279
30GRK51.31558041
31TYRO31.28600977
32TAOK11.27612581
33SIK21.22347565
34RAF11.21741114
35PRKCG1.16636521
36CAMK11.12093496
37UHMK11.02330822
38PTK2B0.99899859
39CAMKK20.94438827
40PRKCH0.93247780
41PNCK0.92867412
42CDK180.91859944
43STK110.91541528
44CDK150.90479308
45PINK10.90358198
46CAMK2A0.89404463
47MAPK130.88561077
48MAPK120.86788036
49PDK10.86123531
50CDK140.85682567
51CASK0.84094183
52ALK0.83878551
53BMPR20.83176812
54SGK4940.82473960
55SGK2230.82473960
56MAP3K10.81306269
57RET0.79664782
58CDK11A0.79409983
59PDPK10.75010976
60OXSR10.74527736
61LATS20.73751322
62PKN10.71408843
63PAK30.70795504
64MAP3K110.70366512
65CAMK2B0.69209358
66SGK10.68606719
67SGK20.67761121
68SGK30.67410643
69TNK20.63771554
70NEK10.62759049
71LIMK10.62070205
72LMTK20.60439855
73MARK20.58829263
74MAP3K70.58200637
75BRSK10.57733083
76DAPK30.57209708
77DYRK1A0.53581857
78CAMK40.52115078
79DMPK0.51586213
80RPS6KA30.48536259
81MAP2K10.47917830
82NEK60.47641728
83PHKG20.47570429
84PHKG10.47570429
85TESK10.47401125
86CSNK1G20.43364827
87CCNB10.42615819
88PRKCZ0.42580629
89RIPK10.42100040
90NME10.40839090
91FGR0.40651687
92FYN0.40635861
93MOS0.40625013
94BRAF0.40478198
95ROCK20.40312920
96MAPK100.40239802
97WNK10.39851903
98CAMK2G0.37046804
99CAMK1G0.35461221
100CAMK2D0.35382884
101FGFR20.34524837
102CDC42BPA0.34157839
103FER0.34137111
104PRKCE0.33490354
105SCYL20.29852773
106PRKCB0.28043109
107JAK20.26837299
108PRKCA0.25989460
109MAPK80.25386490
110MAP3K60.24543241
111CSNK1D0.23896060
112PRKG10.23622789
113MAPKAPK50.23468751
114DYRK20.23318127
115ERBB20.23310769
116PRKACA0.23261071

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45221916
2Synaptic vesicle cycle_Homo sapiens_hsa047213.38413402
3Olfactory transduction_Homo sapiens_hsa047403.08904826
4Long-term potentiation_Homo sapiens_hsa047202.79510034
5Circadian entrainment_Homo sapiens_hsa047132.74982958
6GABAergic synapse_Homo sapiens_hsa047272.63462942
7Glutamatergic synapse_Homo sapiens_hsa047242.60089794
8Amphetamine addiction_Homo sapiens_hsa050312.59867326
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58693052
10Morphine addiction_Homo sapiens_hsa050322.50505458
11Salivary secretion_Homo sapiens_hsa049702.23923672
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23257768
13Dopaminergic synapse_Homo sapiens_hsa047282.15179215
14Insulin secretion_Homo sapiens_hsa049112.08505263
15Gastric acid secretion_Homo sapiens_hsa049712.03309163
16Cholinergic synapse_Homo sapiens_hsa047251.99052357
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95938336
18Nitrogen metabolism_Homo sapiens_hsa009101.80200792
19Oxytocin signaling pathway_Homo sapiens_hsa049211.76297779
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71345193
21Renin secretion_Homo sapiens_hsa049241.69830510
22Calcium signaling pathway_Homo sapiens_hsa040201.64173125
23Cocaine addiction_Homo sapiens_hsa050301.62405903
24Long-term depression_Homo sapiens_hsa047301.59504219
25GnRH signaling pathway_Homo sapiens_hsa049121.54889319
26Serotonergic synapse_Homo sapiens_hsa047261.50662292
27Taste transduction_Homo sapiens_hsa047421.48382387
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45165448
29Vitamin B6 metabolism_Homo sapiens_hsa007501.36599667
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35537169
31Collecting duct acid secretion_Homo sapiens_hsa049661.34711688
32Gap junction_Homo sapiens_hsa045401.33135452
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33053611
34Glioma_Homo sapiens_hsa052141.29359095
35cAMP signaling pathway_Homo sapiens_hsa040241.28843483
36Type II diabetes mellitus_Homo sapiens_hsa049301.17354364
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16842609
38Estrogen signaling pathway_Homo sapiens_hsa049151.14253120
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13395217
40Melanogenesis_Homo sapiens_hsa049161.06717749
41ErbB signaling pathway_Homo sapiens_hsa040121.06504733
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04546356
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98616994
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.95452023
45Oocyte meiosis_Homo sapiens_hsa041140.93690537
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91233591
47Axon guidance_Homo sapiens_hsa043600.89792951
48Dorso-ventral axis formation_Homo sapiens_hsa043200.89014821
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88628929
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.88249601
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84169982
52Pancreatic secretion_Homo sapiens_hsa049720.83282425
53Cardiac muscle contraction_Homo sapiens_hsa042600.82964290
54Vibrio cholerae infection_Homo sapiens_hsa051100.81728448
55Thyroid hormone synthesis_Homo sapiens_hsa049180.79283861
56VEGF signaling pathway_Homo sapiens_hsa043700.75837538
57Choline metabolism in cancer_Homo sapiens_hsa052310.73050351
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70570615
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68923304
60Dilated cardiomyopathy_Homo sapiens_hsa054140.68638012
61MAPK signaling pathway_Homo sapiens_hsa040100.68318147
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66945744
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.66831958
64Glucagon signaling pathway_Homo sapiens_hsa049220.61942303
65Phototransduction_Homo sapiens_hsa047440.61496555
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60422178
67Rap1 signaling pathway_Homo sapiens_hsa040150.58892030
68Type I diabetes mellitus_Homo sapiens_hsa049400.58546309
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57348246
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.56733902
71Ras signaling pathway_Homo sapiens_hsa040140.56287478
72mTOR signaling pathway_Homo sapiens_hsa041500.56080248
73Non-small cell lung cancer_Homo sapiens_hsa052230.55541192
74Endocytosis_Homo sapiens_hsa041440.54316465
75Bile secretion_Homo sapiens_hsa049760.51771152
76Prion diseases_Homo sapiens_hsa050200.50146688
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49515695
78Inositol phosphate metabolism_Homo sapiens_hsa005620.48735614
79African trypanosomiasis_Homo sapiens_hsa051430.48648671
80Alcoholism_Homo sapiens_hsa050340.46397925
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42782978
82Chemokine signaling pathway_Homo sapiens_hsa040620.40326534
83Circadian rhythm_Homo sapiens_hsa047100.40103663
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39284711
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38350173
86Endometrial cancer_Homo sapiens_hsa052130.38272849
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38029322
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37691964
89Insulin signaling pathway_Homo sapiens_hsa049100.37080991
90Renal cell carcinoma_Homo sapiens_hsa052110.36285488
91Wnt signaling pathway_Homo sapiens_hsa043100.35870685
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34579639
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34486926
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34368291
95Arginine and proline metabolism_Homo sapiens_hsa003300.34217401
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32197674
97Arginine biosynthesis_Homo sapiens_hsa002200.30955403
98Alzheimers disease_Homo sapiens_hsa050100.30915747
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30787627
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28714868
101Ovarian steroidogenesis_Homo sapiens_hsa049130.28113722
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28000222
103Fatty acid biosynthesis_Homo sapiens_hsa000610.27383731
104AMPK signaling pathway_Homo sapiens_hsa041520.26709237
105Platelet activation_Homo sapiens_hsa046110.25112271
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20792464
107Histidine metabolism_Homo sapiens_hsa003400.20329036
108HIF-1 signaling pathway_Homo sapiens_hsa040660.19557865
109Mineral absorption_Homo sapiens_hsa049780.19465636
110beta-Alanine metabolism_Homo sapiens_hsa004100.19122067
111Tight junction_Homo sapiens_hsa045300.18858238
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18377119
113Regulation of autophagy_Homo sapiens_hsa041400.18053698

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