

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | purine nucleobase biosynthetic process (GO:0009113) | 6.32658551 |
| 2 | ribosome assembly (GO:0042255) | 5.98206155 |
| 3 | nucleobase biosynthetic process (GO:0046112) | 5.90011397 |
| 4 | folic acid metabolic process (GO:0046655) | 5.30158395 |
| 5 | DNA unwinding involved in DNA replication (GO:0006268) | 4.94919082 |
| 6 | proteasome assembly (GO:0043248) | 4.93586628 |
| 7 | mitotic metaphase plate congression (GO:0007080) | 4.91413956 |
| 8 | ribosome biogenesis (GO:0042254) | 4.90463023 |
| 9 | formation of translation preinitiation complex (GO:0001731) | 4.62957296 |
| 10 | rRNA modification (GO:0000154) | 4.53832732 |
| 11 | DNA deamination (GO:0045006) | 4.51448224 |
| 12 | folic acid transport (GO:0015884) | 4.50992382 |
| 13 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.45525454 |
| 14 | DNA replication checkpoint (GO:0000076) | 4.35491751 |
| 15 | maturation of SSU-rRNA (GO:0030490) | 4.31099137 |
| 16 | termination of RNA polymerase III transcription (GO:0006386) | 4.24959744 |
| 17 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.24959744 |
| 18 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.20978504 |
| 19 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.15678933 |
| 20 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.14578187 |
| 21 | ribosomal small subunit biogenesis (GO:0042274) | 4.14394667 |
| 22 | regulation of spindle organization (GO:0090224) | 4.10208000 |
| 23 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.08664248 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.04229678 |
| 25 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.04179035 |
| 26 | termination of RNA polymerase I transcription (GO:0006363) | 3.96230466 |
| 27 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.93939910 |
| 28 | intestinal epithelial cell development (GO:0060576) | 3.91964988 |
| 29 | transcription from RNA polymerase I promoter (GO:0006360) | 3.86045984 |
| 30 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.85702653 |
| 31 | transcription from mitochondrial promoter (GO:0006390) | 3.84928734 |
| 32 | rRNA processing (GO:0006364) | 3.79208765 |
| 33 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.77771635 |
| 34 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.77270639 |
| 35 | ribosomal large subunit biogenesis (GO:0042273) | 3.75128484 |
| 36 | 7-methylguanosine mRNA capping (GO:0006370) | 3.73606327 |
| 37 | establishment of integrated proviral latency (GO:0075713) | 3.73421163 |
| 38 | metaphase plate congression (GO:0051310) | 3.71821663 |
| 39 | spliceosomal snRNP assembly (GO:0000387) | 3.71731785 |
| 40 | regulation of translation in response to stress (GO:0043555) | 3.71723563 |
| 41 | telomere maintenance via recombination (GO:0000722) | 3.70023569 |
| 42 | blastocyst development (GO:0001824) | 3.69389437 |
| 43 | rRNA metabolic process (GO:0016072) | 3.67656933 |
| 44 | amino acid salvage (GO:0043102) | 3.66122306 |
| 45 | L-methionine salvage (GO:0071267) | 3.66122306 |
| 46 | L-methionine biosynthetic process (GO:0071265) | 3.66122306 |
| 47 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.65744408 |
| 48 | viral mRNA export from host cell nucleus (GO:0046784) | 3.65085665 |
| 49 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.64043997 |
| 50 | negative regulation of ligase activity (GO:0051352) | 3.64043997 |
| 51 | DNA strand renaturation (GO:0000733) | 3.63039080 |
| 52 | RNA capping (GO:0036260) | 3.60455959 |
| 53 | 7-methylguanosine RNA capping (GO:0009452) | 3.60455959 |
| 54 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.58537221 |
| 55 | mitochondrial RNA metabolic process (GO:0000959) | 3.56875846 |
| 56 | DNA replication initiation (GO:0006270) | 3.56793357 |
| 57 | mitotic chromosome condensation (GO:0007076) | 3.54411816 |
| 58 | positive regulation of ligase activity (GO:0051351) | 3.54304086 |
| 59 | lung-associated mesenchyme development (GO:0060484) | 3.53503416 |
| 60 | mitotic recombination (GO:0006312) | 3.53428266 |
| 61 | vitamin transmembrane transport (GO:0035461) | 3.50526616 |
| 62 | base-excision repair, AP site formation (GO:0006285) | 3.50327466 |
| 63 | regulation of mitochondrial translation (GO:0070129) | 3.49000519 |
| 64 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.47494693 |
| 65 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.42858649 |
| 66 | ribosomal small subunit assembly (GO:0000028) | 3.41645572 |
| 67 | pseudouridine synthesis (GO:0001522) | 3.41464370 |
| 68 | protein localization to kinetochore (GO:0034501) | 3.39918550 |
| 69 | mitotic sister chromatid segregation (GO:0000070) | 3.38890310 |
| 70 | positive regulation of chromosome segregation (GO:0051984) | 3.37586764 |
| 71 | maturation of 5.8S rRNA (GO:0000460) | 3.36958871 |
| 72 | mitotic nuclear envelope disassembly (GO:0007077) | 3.36256339 |
| 73 | rRNA methylation (GO:0031167) | 3.34748614 |
| 74 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.32882325 |
| 75 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.32637552 |
| 76 | CENP-A containing nucleosome assembly (GO:0034080) | 3.31728176 |
| 77 | protein localization to chromosome, centromeric region (GO:0071459) | 3.31677052 |
| 78 | chromatin remodeling at centromere (GO:0031055) | 3.31550178 |
| 79 | nuclear pore complex assembly (GO:0051292) | 3.28509439 |
| 80 | DNA duplex unwinding (GO:0032508) | 3.28431791 |
| 81 | interferon-gamma secretion (GO:0072643) | 3.26721047 |
| 82 | spindle checkpoint (GO:0031577) | 3.26228049 |
| 83 | base-excision repair (GO:0006284) | 3.25921953 |
| 84 | rRNA transcription (GO:0009303) | 3.24790530 |
| 85 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.24448219 |
| 86 | regulation of translational termination (GO:0006449) | 3.23474547 |
| 87 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.23447802 |
| 88 | regulation of mitotic spindle organization (GO:0060236) | 3.21341942 |
| 89 | negative regulation of chromosome segregation (GO:0051985) | 3.20929223 |
| 90 | negative regulation of mRNA processing (GO:0050686) | 3.20824821 |
| 91 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.19605561 |
| 92 | mitotic spindle checkpoint (GO:0071174) | 3.18859731 |
| 93 | DNA geometric change (GO:0032392) | 3.18408116 |
| 94 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.17805526 |
| 95 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.17805526 |
| 96 | glycine metabolic process (GO:0006544) | 3.17442984 |
| 97 | methionine biosynthetic process (GO:0009086) | 3.17370895 |
| 98 | meiotic chromosome segregation (GO:0045132) | 3.15933183 |
| 99 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.15838725 |
| 100 | negative regulation of sister chromatid segregation (GO:0033046) | 3.15838725 |
| 101 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.15838725 |
| 102 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.15838725 |
| 103 | cell cycle G1/S phase transition (GO:0044843) | 3.15609030 |
| 104 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.15609030 |
| 105 | regulation of ligase activity (GO:0051340) | 3.15074468 |
| 106 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.14741716 |
| 107 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.14741716 |
| 108 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.14741716 |
| 109 | mitotic spindle assembly checkpoint (GO:0007094) | 3.14615825 |
| 110 | oxidative phosphorylation (GO:0006119) | 3.13854024 |
| 111 | tRNA methylation (GO:0030488) | 3.13627200 |
| 112 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.12328176 |
| 113 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.11878110 |
| 114 | negative regulation of translational initiation (GO:0045947) | 3.10641350 |
| 115 | deoxyribonucleotide catabolic process (GO:0009264) | 3.10234060 |
| 116 | nuclear envelope disassembly (GO:0051081) | 3.10079445 |
| 117 | membrane disassembly (GO:0030397) | 3.10079445 |
| 118 | cellular component biogenesis (GO:0044085) | 3.08908766 |
| 119 | ncRNA 3-end processing (GO:0043628) | 3.08821901 |
| 120 | GMP metabolic process (GO:0046037) | 3.08470313 |
| 121 | regulation of translational fidelity (GO:0006450) | 3.07792550 |
| 122 | telomere maintenance via telomere lengthening (GO:0010833) | 3.07463056 |
| 123 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.07190285 |
| 124 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.07190285 |
| 125 | deoxyribose phosphate catabolic process (GO:0046386) | 3.06968355 |
| 126 | DNA strand elongation (GO:0022616) | 3.06581081 |
| 127 | spindle assembly checkpoint (GO:0071173) | 3.06515539 |
| 128 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.05747935 |
| 129 | regulation of chromosome segregation (GO:0051983) | 3.05717623 |
| 130 | chaperone-mediated protein transport (GO:0072321) | 3.04819418 |
| 131 | ncRNA processing (GO:0034470) | 3.03327047 |
| 132 | establishment of chromosome localization (GO:0051303) | 3.02976034 |
| 133 | IMP biosynthetic process (GO:0006188) | 3.02555719 |
| 134 | negative regulation of mRNA metabolic process (GO:1903312) | 3.01494255 |
| 135 | DNA-templated transcription, elongation (GO:0006354) | 3.01427046 |
| 136 | negative regulation of RNA splicing (GO:0033119) | 3.01092607 |
| 137 | protein targeting to mitochondrion (GO:0006626) | 2.99441740 |
| 138 | sister chromatid segregation (GO:0000819) | 2.99102911 |
| 139 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.98960261 |
| 140 | establishment of viral latency (GO:0019043) | 2.98763929 |
| 141 | termination of RNA polymerase II transcription (GO:0006369) | 2.98499368 |
| 142 | NADH metabolic process (GO:0006734) | 2.97970206 |
| 143 | methionine metabolic process (GO:0006555) | 2.97956231 |
| 144 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.97806732 |
| 145 | L-serine metabolic process (GO:0006563) | 2.97456307 |
| 146 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.96054469 |
| 147 | negative regulation of B cell apoptotic process (GO:0002903) | 2.94734723 |
| 148 | viral transcription (GO:0019083) | 2.94725077 |
| 149 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.93586766 |
| 150 | GDP-mannose metabolic process (GO:0019673) | 2.90836814 |
| 151 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.90738183 |
| 152 | translational termination (GO:0006415) | 2.90410609 |
| 153 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.90264471 |
| 154 | kinetochore organization (GO:0051383) | 2.87406999 |
| 155 | tRNA modification (GO:0006400) | 2.87392192 |
| 156 | histone arginine methylation (GO:0034969) | 2.85450215 |
| 157 | nuclear pore organization (GO:0006999) | 2.83956342 |
| 158 | ncRNA metabolic process (GO:0034660) | 2.83051108 |
| 159 | chromatin assembly or disassembly (GO:0006333) | 2.82267518 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.22893324 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.30457913 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.26821182 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.62526969 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.59259824 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.57081367 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.40035835 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.33518123 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.29413538 |
| 10 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.23908053 |
| 11 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.19524631 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.12249162 |
| 13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.04903409 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.91048888 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.70346736 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.63675874 |
| 17 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.62794161 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.50769882 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.46077535 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.32385250 |
| 21 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.27981438 |
| 22 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.27437258 |
| 23 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.26627814 |
| 24 | * MYC_22102868_ChIP-Seq_BL_Human | 2.22004114 |
| 25 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.21714032 |
| 26 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.17852157 |
| 27 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.12869898 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.10113052 |
| 29 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 2.07412317 |
| 30 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.04475937 |
| 31 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.03343216 |
| 32 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.03149987 |
| 33 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.99654468 |
| 34 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.98336197 |
| 35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.98331105 |
| 36 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.96232230 |
| 37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.93335449 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.91118269 |
| 39 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.81263149 |
| 40 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.69959423 |
| 41 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.69085317 |
| 42 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.64621781 |
| 43 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.62254025 |
| 44 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.61924794 |
| 45 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.60470908 |
| 46 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.59198469 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.54926454 |
| 48 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.51351672 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.49280928 |
| 50 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.46736800 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.43076636 |
| 52 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.42414707 |
| 53 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.41637252 |
| 54 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.41145282 |
| 55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39024922 |
| 56 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38641454 |
| 57 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.34705357 |
| 58 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.33262971 |
| 59 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.32634086 |
| 60 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.30921167 |
| 61 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.26332226 |
| 62 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.26096922 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.25110722 |
| 64 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25024139 |
| 65 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.22233619 |
| 66 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.21722419 |
| 67 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.20556099 |
| 68 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.19770420 |
| 69 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18983521 |
| 70 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.17600047 |
| 71 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.17331833 |
| 72 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.17331833 |
| 73 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.17331833 |
| 74 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.17005601 |
| 75 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.15338677 |
| 76 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.15175166 |
| 77 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.14299112 |
| 78 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.13897877 |
| 79 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.13498237 |
| 80 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.11829541 |
| 81 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.11010522 |
| 82 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.10507850 |
| 83 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.09728160 |
| 84 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.09693879 |
| 85 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08963830 |
| 86 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.08006700 |
| 87 | * P68_20966046_ChIP-Seq_HELA_Human | 1.07680452 |
| 88 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.07005060 |
| 89 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.06774168 |
| 90 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.05871224 |
| 91 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.05819245 |
| 92 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.05341525 |
| 93 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.02548539 |
| 94 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.02256646 |
| 95 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.00512038 |
| 96 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.99278236 |
| 97 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.99221909 |
| 98 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98353359 |
| 99 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.97981127 |
| 100 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.97813103 |
| 101 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.97604728 |
| 102 | MAF_26560356_Chip-Seq_TH2_Human | 0.97457343 |
| 103 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.96661777 |
| 104 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.96162309 |
| 105 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.96045302 |
| 106 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.94648242 |
| 107 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.94448711 |
| 108 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.93834455 |
| 109 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92798704 |
| 110 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.92691029 |
| 111 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.92066026 |
| 112 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91067977 |
| 113 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 0.90925411 |
| 114 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.90674944 |
| 115 | * TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.90602011 |
| 116 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.89890146 |
| 117 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.89798143 |
| 118 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.89759729 |
| 119 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.88534742 |
| 120 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85626002 |
| 121 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.85233317 |
| 122 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.84859073 |
| 123 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.84766262 |
| 124 | * CTCF_21964334_Chip-Seq_Bcells_Human | 0.84629575 |
| 125 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.84079135 |
| 126 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.82914745 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 7.01789945 |
| 2 | MP0003111_abnormal_nucleus_morphology | 5.29841685 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.87576183 |
| 4 | MP0003077_abnormal_cell_cycle | 3.76412132 |
| 5 | MP0003718_maternal_effect | 3.75449911 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.74233306 |
| 7 | MP0009840_abnormal_foam_cell | 3.04208300 |
| 8 | MP0008260_abnormal_autophagy | 3.03718097 |
| 9 | MP0008058_abnormal_DNA_repair | 2.88247918 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.75276858 |
| 11 | MP0008057_abnormal_DNA_replication | 2.71488731 |
| 12 | MP0003123_paternal_imprinting | 2.63463926 |
| 13 | MP0001730_embryonic_growth_arrest | 2.63289489 |
| 14 | MP0003786_premature_aging | 2.44187266 |
| 15 | MP0005083_abnormal_biliary_tract | 2.05911453 |
| 16 | MP0001672_abnormal_embryogenesis/_devel | 2.02114241 |
| 17 | MP0005380_embryogenesis_phenotype | 2.02114241 |
| 18 | MP0000350_abnormal_cell_proliferation | 1.98191196 |
| 19 | MP0003315_abnormal_perineum_morphology | 1.93431008 |
| 20 | MP0005377_hearing/vestibular/ear_phenot | 1.88116553 |
| 21 | MP0003878_abnormal_ear_physiology | 1.88116553 |
| 22 | MP0008007_abnormal_cellular_replicative | 1.82164313 |
| 23 | MP0008877_abnormal_DNA_methylation | 1.79033442 |
| 24 | MP0010352_gastrointestinal_tract_polyps | 1.74228817 |
| 25 | MP0003984_embryonic_growth_retardation | 1.74175635 |
| 26 | MP0002088_abnormal_embryonic_growth/wei | 1.71778680 |
| 27 | MP0001697_abnormal_embryo_size | 1.69394254 |
| 28 | MP0002080_prenatal_lethality | 1.68865068 |
| 29 | MP0003646_muscle_fatigue | 1.62848870 |
| 30 | MP0001661_extended_life_span | 1.60026415 |
| 31 | MP0005451_abnormal_body_composition | 1.51299428 |
| 32 | MP0006035_abnormal_mitochondrial_morpho | 1.49110235 |
| 33 | MP0000750_abnormal_muscle_regeneration | 1.44402201 |
| 34 | MP0005395_other_phenotype | 1.43899745 |
| 35 | MP0010307_abnormal_tumor_latency | 1.43880542 |
| 36 | MP0002085_abnormal_embryonic_tissue | 1.43103199 |
| 37 | MP0003567_abnormal_fetal_cardiomyocyte | 1.42908114 |
| 38 | MP0003806_abnormal_nucleotide_metabolis | 1.41662656 |
| 39 | MP0003221_abnormal_cardiomyocyte_apopto | 1.41197053 |
| 40 | MP0005423_abnormal_somatic_nervous | 1.37405417 |
| 41 | MP0002086_abnormal_extraembryonic_tissu | 1.33456150 |
| 42 | MP0001542_abnormal_bone_strength | 1.30838628 |
| 43 | MP0003941_abnormal_skin_development | 1.29346155 |
| 44 | MP0000358_abnormal_cell_content/ | 1.27466953 |
| 45 | MP0005076_abnormal_cell_differentiation | 1.25607561 |
| 46 | MP0001727_abnormal_embryo_implantation | 1.25271135 |
| 47 | MP0004019_abnormal_vitamin_homeostasis | 1.25241216 |
| 48 | MP0009333_abnormal_splenocyte_physiolog | 1.24647193 |
| 49 | MP0002084_abnormal_developmental_patter | 1.22802096 |
| 50 | MP0005171_absent_coat_pigmentation | 1.21826350 |
| 51 | MP0002210_abnormal_sex_determination | 1.20624272 |
| 52 | MP0001986_abnormal_taste_sensitivity | 1.18453912 |
| 53 | MP0001145_abnormal_male_reproductive | 1.16278026 |
| 54 | MP0002396_abnormal_hematopoietic_system | 1.15966344 |
| 55 | MP0005670_abnormal_white_adipose | 1.15875122 |
| 56 | MP0004808_abnormal_hematopoietic_stem | 1.15776879 |
| 57 | MP0006036_abnormal_mitochondrial_physio | 1.14510898 |
| 58 | MP0002653_abnormal_ependyma_morphology | 1.14328560 |
| 59 | MP0000313_abnormal_cell_death | 1.12934724 |
| 60 | MP0003938_abnormal_ear_development | 1.08433287 |
| 61 | MP0004233_abnormal_muscle_weight | 1.07480925 |
| 62 | MP0000490_abnormal_crypts_of | 1.05850290 |
| 63 | MP0009278_abnormal_bone_marrow | 1.05736074 |
| 64 | MP0001929_abnormal_gametogenesis | 1.04642830 |
| 65 | MP0003119_abnormal_digestive_system | 1.04225748 |
| 66 | MP0005220_abnormal_exocrine_pancreas | 1.02889662 |
| 67 | MP0005174_abnormal_tail_pigmentation | 1.02875674 |
| 68 | MP0004084_abnormal_cardiac_muscle | 1.01624773 |
| 69 | MP0009697_abnormal_copulation | 0.98253592 |
| 70 | MP0004185_abnormal_adipocyte_glucose | 0.97325107 |
| 71 | MP0009379_abnormal_foot_pigmentation | 0.97195722 |
| 72 | MP0005389_reproductive_system_phenotype | 0.96916456 |
| 73 | MP0009672_abnormal_birth_weight | 0.96897431 |
| 74 | MP0000703_abnormal_thymus_morphology | 0.96150738 |
| 75 | MP0003763_abnormal_thymus_physiology | 0.94555041 |
| 76 | MP0004197_abnormal_fetal_growth/weight/ | 0.94507660 |
| 77 | MP0001756_abnormal_urination | 0.93993822 |
| 78 | MP0000653_abnormal_sex_gland | 0.93183593 |
| 79 | MP0002019_abnormal_tumor_incidence | 0.92218465 |
| 80 | MP0002160_abnormal_reproductive_system | 0.91473095 |
| 81 | MP0000747_muscle_weakness | 0.90758714 |
| 82 | MP0003136_yellow_coat_color | 0.90414261 |
| 83 | MP0000537_abnormal_urethra_morphology | 0.89917718 |
| 84 | MP0003186_abnormal_redox_activity | 0.88175281 |
| 85 | MP0010030_abnormal_orbit_morphology | 0.87399170 |
| 86 | MP0005384_cellular_phenotype | 0.86125138 |
| 87 | MP0010234_abnormal_vibrissa_follicle | 0.84464065 |
| 88 | MP0005332_abnormal_amino_acid | 0.84241000 |
| 89 | MP0002269_muscular_atrophy | 0.84036773 |
| 90 | MP0001293_anophthalmia | 0.83908413 |
| 91 | MP0005621_abnormal_cell_physiology | 0.83231786 |
| 92 | MP0001919_abnormal_reproductive_system | 0.82931480 |
| 93 | MP0008789_abnormal_olfactory_epithelium | 0.82862541 |
| 94 | MP0002254_reproductive_system_inflammat | 0.81955013 |
| 95 | MP0000015_abnormal_ear_pigmentation | 0.81107467 |
| 96 | MP0005075_abnormal_melanosome_morpholog | 0.80272998 |
| 97 | MP0002398_abnormal_bone_marrow | 0.79861644 |
| 98 | MP0004147_increased_porphyrin_level | 0.79618174 |
| 99 | MP0000627_abnormal_mammary_gland | 0.79539418 |
| 100 | MP0002722_abnormal_immune_system | 0.78492162 |
| 101 | MP0002877_abnormal_melanocyte_morpholog | 0.76405986 |
| 102 | MP0005330_cardiomyopathy | 0.74322044 |
| 103 | MP0009931_abnormal_skin_appearance | 0.73988384 |
| 104 | MP0004133_heterotaxia | 0.71957338 |
| 105 | MP0000477_abnormal_intestine_morphology | 0.70716457 |
| 106 | MP0003937_abnormal_limbs/digits/tail_de | 0.69979504 |
| 107 | MP0001188_hyperpigmentation | 0.69346442 |
| 108 | MP0001849_ear_inflammation | 0.69344342 |
| 109 | MP0002429_abnormal_blood_cell | 0.68481900 |
| 110 | MP0003787_abnormal_imprinting | 0.67544463 |
| 111 | MP0002796_impaired_skin_barrier | 0.67055834 |
| 112 | MP0003699_abnormal_female_reproductive | 0.66411972 |
| 113 | MP0001881_abnormal_mammary_gland | 0.66279762 |
| 114 | MP0002111_abnormal_tail_morphology | 0.66252155 |
| 115 | MP0005499_abnormal_olfactory_system | 0.65898798 |
| 116 | MP0005394_taste/olfaction_phenotype | 0.65898798 |
| 117 | MP0000428_abnormal_craniofacial_morphol | 0.65882632 |
| 118 | MP0005645_abnormal_hypothalamus_physiol | 0.65447146 |
| 119 | MP0000647_abnormal_sebaceous_gland | 0.64815718 |
| 120 | MP0000372_irregular_coat_pigmentation | 0.64705492 |
| 121 | MP0000689_abnormal_spleen_morphology | 0.64586917 |
| 122 | MP0009703_decreased_birth_body | 0.62902263 |
| 123 | MP0001764_abnormal_homeostasis | 0.62887739 |
| 124 | MP0002161_abnormal_fertility/fecundity | 0.62539402 |
| 125 | MP0003936_abnormal_reproductive_system | 0.60798883 |
| 126 | MP0005666_abnormal_adipose_tissue | 0.59014734 |
| 127 | MP0003698_abnormal_male_reproductive | 0.58769270 |
| 128 | MP0006292_abnormal_olfactory_placode | 0.57719881 |
| 129 | MP0002132_abnormal_respiratory_system | 0.57525679 |
| 130 | MP0005501_abnormal_skin_physiology | 0.54029105 |
| 131 | MP0004264_abnormal_extraembryonic_tissu | 0.53262250 |
| 132 | MP0002092_abnormal_eye_morphology | 0.52509336 |
| 133 | MP0002127_abnormal_cardiovascular_syste | 0.52168719 |
| 134 | MP0000383_abnormal_hair_follicle | 0.51402960 |
| 135 | MP0001545_abnormal_hematopoietic_system | 0.51331087 |
| 136 | MP0005397_hematopoietic_system_phenotyp | 0.51331087 |
| 137 | MP0001119_abnormal_female_reproductive | 0.50549939 |
| 138 | MP0003879_abnormal_hair_cell | 0.49792149 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Breast hypoplasia (HP:0003187) | 5.86424716 |
| 2 | Birth length less than 3rd percentile (HP:0003561) | 5.36441210 |
| 3 | Cerebral hypomyelination (HP:0006808) | 4.95993050 |
| 4 | Rough bone trabeculation (HP:0100670) | 4.46108906 |
| 5 | Hyperglycinemia (HP:0002154) | 4.39114923 |
| 6 | Carpal bone hypoplasia (HP:0001498) | 4.33158799 |
| 7 | Hyperglycinuria (HP:0003108) | 3.94862024 |
| 8 | Impulsivity (HP:0100710) | 3.88647546 |
| 9 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.85295283 |
| 10 | Ureteral duplication (HP:0000073) | 3.83959686 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.63958970 |
| 12 | Ragged-red muscle fibers (HP:0003200) | 3.58803336 |
| 13 | Multiple enchondromatosis (HP:0005701) | 3.58110336 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.53619012 |
| 15 | Increased intramyocellular lipid droplets (HP:0012240) | 3.53600885 |
| 16 | Progressive muscle weakness (HP:0003323) | 3.46324982 |
| 17 | Premature ovarian failure (HP:0008209) | 3.43232826 |
| 18 | Abnormality of the umbilical cord (HP:0010881) | 3.39514262 |
| 19 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.35963358 |
| 20 | Patellar aplasia (HP:0006443) | 3.35300892 |
| 21 | Abnormal trabecular bone morphology (HP:0100671) | 3.26589313 |
| 22 | Abnormality of glycine metabolism (HP:0010895) | 3.25370858 |
| 23 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.25370858 |
| 24 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.17001573 |
| 25 | Increased muscle lipid content (HP:0009058) | 3.16131826 |
| 26 | Absent radius (HP:0003974) | 3.14943479 |
| 27 | Secondary amenorrhea (HP:0000869) | 3.13700439 |
| 28 | Poikiloderma (HP:0001029) | 3.09801315 |
| 29 | CNS hypomyelination (HP:0003429) | 3.08169529 |
| 30 | Oral leukoplakia (HP:0002745) | 3.05248115 |
| 31 | Progressive external ophthalmoplegia (HP:0000590) | 3.04684712 |
| 32 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.02249874 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 3.02249874 |
| 34 | Hyperalaninemia (HP:0003348) | 3.02249874 |
| 35 | Aplasia involving forearm bones (HP:0009822) | 2.94237603 |
| 36 | Absent forearm bone (HP:0003953) | 2.94237603 |
| 37 | Megaloblastic anemia (HP:0001889) | 2.92243394 |
| 38 | Abnormality of serum amino acid levels (HP:0003112) | 2.91606625 |
| 39 | Degeneration of anterior horn cells (HP:0002398) | 2.86824333 |
| 40 | Abnormality of the anterior horn cell (HP:0006802) | 2.86824333 |
| 41 | Squamous cell carcinoma (HP:0002860) | 2.85608284 |
| 42 | Type I transferrin isoform profile (HP:0003642) | 2.84550609 |
| 43 | Death in infancy (HP:0001522) | 2.80114857 |
| 44 | Abnormality of the labia minora (HP:0012880) | 2.79910328 |
| 45 | Renal Fanconi syndrome (HP:0001994) | 2.79733698 |
| 46 | Increased CSF lactate (HP:0002490) | 2.78677592 |
| 47 | Reduced antithrombin III activity (HP:0001976) | 2.76980198 |
| 48 | Trismus (HP:0000211) | 2.75403542 |
| 49 | Hepatocellular necrosis (HP:0001404) | 2.67960070 |
| 50 | Microretrognathia (HP:0000308) | 2.67356243 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.65540439 |
| 52 | Entropion (HP:0000621) | 2.61197997 |
| 53 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.58309358 |
| 54 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.57619241 |
| 55 | Respiratory difficulties (HP:0002880) | 2.55598897 |
| 56 | Gout (HP:0001997) | 2.54292255 |
| 57 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.53707509 |
| 58 | Mitochondrial inheritance (HP:0001427) | 2.53229687 |
| 59 | Personality changes (HP:0000751) | 2.49775844 |
| 60 | Sparse eyelashes (HP:0000653) | 2.46699918 |
| 61 | Bundle branch block (HP:0011710) | 2.45550114 |
| 62 | Delusions (HP:0000746) | 2.43597224 |
| 63 | Pelvic girdle muscle weakness (HP:0003749) | 2.42981486 |
| 64 | Muscle fiber splitting (HP:0003555) | 2.41510427 |
| 65 | Pallor (HP:0000980) | 2.40676437 |
| 66 | Prolonged neonatal jaundice (HP:0006579) | 2.39346262 |
| 67 | Patent foramen ovale (HP:0001655) | 2.37678522 |
| 68 | Areflexia of lower limbs (HP:0002522) | 2.36581524 |
| 69 | Postnatal microcephaly (HP:0005484) | 2.34361088 |
| 70 | Macrocytic anemia (HP:0001972) | 2.33618071 |
| 71 | Aplastic anemia (HP:0001915) | 2.32670311 |
| 72 | Shoulder girdle muscle weakness (HP:0003547) | 2.31673016 |
| 73 | Atrioventricular block (HP:0001678) | 2.31312393 |
| 74 | Difficulty climbing stairs (HP:0003551) | 2.30450002 |
| 75 | Exercise intolerance (HP:0003546) | 2.30421691 |
| 76 | CNS demyelination (HP:0007305) | 2.28959299 |
| 77 | Abnormal glycosylation (HP:0012345) | 2.27685020 |
| 78 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.27685020 |
| 79 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.27685020 |
| 80 | Abnormal protein glycosylation (HP:0012346) | 2.27685020 |
| 81 | Horseshoe kidney (HP:0000085) | 2.26120704 |
| 82 | Cerebral edema (HP:0002181) | 2.25466337 |
| 83 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.25247977 |
| 84 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.25247977 |
| 85 | Pancytopenia (HP:0001876) | 2.22434310 |
| 86 | Testicular atrophy (HP:0000029) | 2.22242740 |
| 87 | Lactic acidosis (HP:0003128) | 2.21875441 |
| 88 | Neoplasm of the pancreas (HP:0002894) | 2.21081008 |
| 89 | Ventricular fibrillation (HP:0001663) | 2.20392923 |
| 90 | Abnormal spermatogenesis (HP:0008669) | 2.18928529 |
| 91 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.18706881 |
| 92 | Meckel diverticulum (HP:0002245) | 2.18162655 |
| 93 | Abnormality of the preputium (HP:0100587) | 2.16320195 |
| 94 | Acute encephalopathy (HP:0006846) | 2.15747321 |
| 95 | Hepatic necrosis (HP:0002605) | 2.15721591 |
| 96 | Dyschromatopsia (HP:0007641) | 2.15462198 |
| 97 | Breast aplasia (HP:0100783) | 2.15404556 |
| 98 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.14791610 |
| 99 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.13889329 |
| 100 | Selective tooth agenesis (HP:0001592) | 2.13077879 |
| 101 | Acute necrotizing encephalopathy (HP:0006965) | 2.13063540 |
| 102 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.12147990 |
| 103 | Congenital, generalized hypertrichosis (HP:0004540) | 2.11030987 |
| 104 | Hypoplasia of the pons (HP:0012110) | 2.10066229 |
| 105 | Spinal muscular atrophy (HP:0007269) | 2.09542593 |
| 106 | Short thumb (HP:0009778) | 2.09377042 |
| 107 | Unsteady gait (HP:0002317) | 2.09312832 |
| 108 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 2.09307032 |
| 109 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.08675827 |
| 110 | Rib fusion (HP:0000902) | 2.08267932 |
| 111 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.06902376 |
| 112 | Tetraplegia (HP:0002445) | 2.06528482 |
| 113 | Vaginal fistula (HP:0004320) | 2.06502129 |
| 114 | Rectal fistula (HP:0100590) | 2.05411850 |
| 115 | Rectovaginal fistula (HP:0000143) | 2.05411850 |
| 116 | Myelodysplasia (HP:0002863) | 2.05356029 |
| 117 | Reticulocytopenia (HP:0001896) | 2.05198259 |
| 118 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.05052324 |
| 119 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.04294467 |
| 120 | Premature graying of hair (HP:0002216) | 2.04053439 |
| 121 | Absent hand (HP:0004050) | 2.03200154 |
| 122 | Abnormality of the ileum (HP:0001549) | 2.01951143 |
| 123 | Bone marrow hypocellularity (HP:0005528) | 2.01829851 |
| 124 | Dysautonomia (HP:0002459) | 2.01720504 |
| 125 | Facial cleft (HP:0002006) | 2.01267111 |
| 126 | Absent thumb (HP:0009777) | 2.01013146 |
| 127 | Nausea (HP:0002018) | 2.00811183 |
| 128 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.97837353 |
| 129 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.97837353 |
| 130 | Intestinal fistula (HP:0100819) | 1.97119942 |
| 131 | Ependymoma (HP:0002888) | 1.95704150 |
| 132 | Glossoptosis (HP:0000162) | 1.95104345 |
| 133 | Hypergonadotropic hypogonadism (HP:0000815) | 1.90643469 |
| 134 | Abnormal number of erythroid precursors (HP:0012131) | 1.90186665 |
| 135 | Cellular immunodeficiency (HP:0005374) | 1.89949937 |
| 136 | Microvesicular hepatic steatosis (HP:0001414) | 1.89635998 |
| 137 | Lethargy (HP:0001254) | 1.88644458 |
| 138 | Sparse lateral eyebrow (HP:0005338) | 1.87025506 |
| 139 | Hypoplasia of the radius (HP:0002984) | 1.86166782 |
| 140 | Abnormality of the pons (HP:0007361) | 1.85726267 |
| 141 | Colon cancer (HP:0003003) | 1.82358629 |
| 142 | Cleft eyelid (HP:0000625) | 1.82305067 |
| 143 | Irregular epiphyses (HP:0010582) | 1.81727838 |
| 144 | Chromsome breakage (HP:0040012) | 1.81393880 |
| 145 | Increased serum lactate (HP:0002151) | 1.81351294 |
| 146 | External ophthalmoplegia (HP:0000544) | 1.81135575 |
| 147 | Abnormality of glycolysis (HP:0004366) | 1.80684941 |
| 148 | Increased serum pyruvate (HP:0003542) | 1.78971650 |
| 149 | Muscle fibrillation (HP:0010546) | 1.78783647 |
| 150 | Abnormality of chromosome stability (HP:0003220) | 1.78766140 |
| 151 | Proximal placement of thumb (HP:0009623) | 1.78191084 |
| 152 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.77752332 |
| 153 | Thrombocytosis (HP:0001894) | 1.74329602 |
| 154 | Acute lymphatic leukemia (HP:0006721) | 1.72849127 |
| 155 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.72347864 |
| 156 | Villous atrophy (HP:0011473) | 1.72347864 |
| 157 | Impaired proprioception (HP:0010831) | 1.70791340 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 6.79238966 |
| 2 | WEE1 | 4.98502817 |
| 3 | VRK2 | 4.13072218 |
| 4 | EPHA2 | 4.10215758 |
| 5 | PBK | 3.67694431 |
| 6 | TSSK6 | 3.25051175 |
| 7 | EIF2AK1 | 3.06180134 |
| 8 | SMG1 | 3.05471054 |
| 9 | PLK4 | 2.98510431 |
| 10 | AKT3 | 2.89904618 |
| 11 | STK16 | 2.59199054 |
| 12 | NEK2 | 2.52908494 |
| 13 | PNCK | 2.51966135 |
| 14 | TTK | 2.49345258 |
| 15 | NME2 | 2.37408772 |
| 16 | NEK1 | 2.31373334 |
| 17 | SRPK1 | 2.22407877 |
| 18 | BRSK2 | 1.91774294 |
| 19 | PLK1 | 1.87122760 |
| 20 | EIF2AK3 | 1.81245142 |
| 21 | PDK4 | 1.75474735 |
| 22 | PDK3 | 1.75474735 |
| 23 | DYRK3 | 1.64963187 |
| 24 | ZAK | 1.63472384 |
| 25 | PLK3 | 1.61942201 |
| 26 | CDC7 | 1.58364697 |
| 27 | MAP3K10 | 1.56601751 |
| 28 | TAF1 | 1.49235485 |
| 29 | IRAK3 | 1.42743098 |
| 30 | ACVR1B | 1.40599873 |
| 31 | PDK2 | 1.35656850 |
| 32 | BRSK1 | 1.35422806 |
| 33 | NME1 | 1.34566682 |
| 34 | STK38L | 1.32029936 |
| 35 | AURKA | 1.29291778 |
| 36 | AURKB | 1.25812832 |
| 37 | EEF2K | 1.22846785 |
| 38 | TESK2 | 1.22277092 |
| 39 | CHEK2 | 1.19869635 |
| 40 | NUAK1 | 1.17053313 |
| 41 | CCNB1 | 1.15849051 |
| 42 | PINK1 | 1.15545071 |
| 43 | BCKDK | 1.14202208 |
| 44 | LATS2 | 1.13293467 |
| 45 | MKNK2 | 1.07905917 |
| 46 | BRAF | 1.07254200 |
| 47 | MAP3K8 | 1.06547088 |
| 48 | MUSK | 1.04693950 |
| 49 | RPS6KB2 | 1.01516041 |
| 50 | CDK7 | 0.99348361 |
| 51 | DAPK1 | 0.96703208 |
| 52 | ARAF | 0.95879805 |
| 53 | CDK4 | 0.95670790 |
| 54 | PRKCI | 0.94592179 |
| 55 | ALK | 0.94249477 |
| 56 | PIM2 | 0.94003597 |
| 57 | WNK4 | 0.87876824 |
| 58 | STK3 | 0.82788438 |
| 59 | CHEK1 | 0.82723649 |
| 60 | RPS6KA4 | 0.82300614 |
| 61 | MKNK1 | 0.79247178 |
| 62 | PAK1 | 0.78711006 |
| 63 | TLK1 | 0.75916438 |
| 64 | ATR | 0.74083052 |
| 65 | MAP2K2 | 0.70226359 |
| 66 | MST1R | 0.69302029 |
| 67 | CDK8 | 0.67268695 |
| 68 | PAK4 | 0.67060267 |
| 69 | VRK1 | 0.66519844 |
| 70 | PRPF4B | 0.65616461 |
| 71 | CDK2 | 0.61393823 |
| 72 | ERN1 | 0.61196972 |
| 73 | EIF2AK2 | 0.59979369 |
| 74 | SIK1 | 0.59977000 |
| 75 | MST4 | 0.57140596 |
| 76 | CSNK2A2 | 0.55988392 |
| 77 | CDK6 | 0.55557080 |
| 78 | FLT3 | 0.55173859 |
| 79 | CSNK1E | 0.54926124 |
| 80 | MAP4K1 | 0.53344918 |
| 81 | CSNK2A1 | 0.52933590 |
| 82 | STK24 | 0.50309533 |
| 83 | MAP3K11 | 0.48924013 |
| 84 | MAPK11 | 0.48623041 |
| 85 | OXSR1 | 0.48316178 |
| 86 | DAPK3 | 0.48117891 |
| 87 | DYRK2 | 0.47470149 |
| 88 | ICK | 0.46283765 |
| 89 | MELK | 0.44846992 |
| 90 | PASK | 0.44735862 |
| 91 | STK39 | 0.44371913 |
| 92 | CDK9 | 0.44136257 |
| 93 | CDK1 | 0.40480005 |
| 94 | MAPK15 | 0.40193111 |
| 95 | RPS6KA1 | 0.37292262 |
| 96 | ABL2 | 0.36944729 |
| 97 | PIM1 | 0.36038022 |
| 98 | STK10 | 0.34808615 |
| 99 | TAOK2 | 0.33996619 |
| 100 | ATM | 0.32986625 |
| 101 | MAPKAPK5 | 0.32173611 |
| 102 | AKT2 | 0.32112171 |
| 103 | MTOR | 0.32096411 |
| 104 | NEK6 | 0.31279970 |
| 105 | STK4 | 0.29879041 |
| 106 | CDK11A | 0.29723560 |
| 107 | KDR | 0.28844742 |
| 108 | BMX | 0.28596819 |
| 109 | MAP3K3 | 0.28118757 |
| 110 | MARK1 | 0.27046026 |
| 111 | PRKCG | 0.26272925 |
| 112 | MAP3K5 | 0.23274946 |
| 113 | RPS6KA5 | 0.22809876 |
| 114 | RAF1 | 0.20768820 |
| 115 | SCYL2 | 0.20479764 |
| 116 | STK38 | 0.20394919 |
| 117 | TAOK1 | 0.20265181 |
| 118 | LATS1 | 0.19718451 |
| 119 | CSNK1G3 | 0.17457569 |
| 120 | CSNK1A1 | 0.17252789 |
| 121 | PRKAA1 | 0.15966395 |
| 122 | CSNK1G1 | 0.15743691 |
| 123 | DDR2 | 0.13959421 |
| 124 | CAMK2G | 0.13867045 |
| 125 | PRKDC | 0.12867961 |
| 126 | IRAK2 | 0.11836784 |
| 127 | MAPK10 | 0.11580015 |
| 128 | GRK6 | 0.11002607 |
| 129 | MARK3 | 0.09985108 |
| 130 | CDK12 | 0.09475311 |
| 131 | MAPK9 | 0.09434075 |
| 132 | MAP3K9 | 0.08561699 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 4.71618177 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.58380137 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.54979087 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.48114931 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.39869774 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 3.13625740 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 2.72872304 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.71793707 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.69500699 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 2.58999633 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.17878630 |
| 12 | Cell cycle_Homo sapiens_hsa04110 | 2.17478323 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.16975887 |
| 14 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.16958087 |
| 15 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.12173638 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.06395662 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 2.05149145 |
| 18 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.85925669 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.78004478 |
| 20 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.74241261 |
| 21 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.70591971 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.66107366 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.62650489 |
| 24 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.62201644 |
| 25 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.52854909 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.51951094 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.45228814 |
| 28 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.39597694 |
| 29 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.37028862 |
| 30 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.32189112 |
| 31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.28068910 |
| 32 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.22449336 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.22418930 |
| 34 | RNA degradation_Homo sapiens_hsa03018 | 1.20589348 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.20144763 |
| 36 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.16627315 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.15551613 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.14947613 |
| 39 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.14885009 |
| 40 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.10196323 |
| 41 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.08587722 |
| 42 | Carbon metabolism_Homo sapiens_hsa01200 | 1.00846842 |
| 43 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.98226092 |
| 44 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.96339035 |
| 45 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.96220713 |
| 46 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91242390 |
| 47 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.91117715 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82762255 |
| 49 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.81258837 |
| 50 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.78553678 |
| 51 | Alzheimers disease_Homo sapiens_hsa05010 | 0.76601290 |
| 52 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.75087299 |
| 53 | Huntingtons disease_Homo sapiens_hsa05016 | 0.74199677 |
| 54 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.73454264 |
| 55 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.71111874 |
| 56 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.69106518 |
| 57 | Alcoholism_Homo sapiens_hsa05034 | 0.61939430 |
| 58 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.60896993 |
| 59 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.58547768 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58328709 |
| 61 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.56826299 |
| 62 | Lysine degradation_Homo sapiens_hsa00310 | 0.53799949 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.51043559 |
| 64 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.49455954 |
| 65 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.48191765 |
| 66 | Parkinsons disease_Homo sapiens_hsa05012 | 0.48007451 |
| 67 | Galactose metabolism_Homo sapiens_hsa00052 | 0.47694264 |
| 68 | Bladder cancer_Homo sapiens_hsa05219 | 0.45512451 |
| 69 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.45391372 |
| 70 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.43390916 |
| 71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.40665444 |
| 72 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.37761024 |
| 73 | Protein export_Homo sapiens_hsa03060 | 0.36047565 |
| 74 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.36022290 |
| 75 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35925003 |
| 76 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.35665831 |
| 77 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.35045115 |
| 78 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.33814087 |
| 79 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.32639399 |
| 80 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.31855770 |
| 81 | Circadian rhythm_Homo sapiens_hsa04710 | 0.31153094 |
| 82 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.28689468 |
| 83 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27352382 |
| 84 | Apoptosis_Homo sapiens_hsa04210 | 0.26159386 |
| 85 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.26008526 |
| 86 | Tight junction_Homo sapiens_hsa04530 | 0.24446859 |
| 87 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.24005077 |
| 88 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.23311570 |
| 89 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.21091974 |
| 90 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.20388167 |
| 91 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.19445840 |
| 92 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.18816660 |
| 93 | HTLV-I infection_Homo sapiens_hsa05166 | 0.18810740 |
| 94 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.18336664 |
| 95 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.18246789 |
| 96 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.17305163 |
| 97 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.16285766 |
| 98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.16225919 |
| 99 | Peroxisome_Homo sapiens_hsa04146 | 0.16103417 |
| 100 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.15822793 |
| 101 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.14465506 |
| 102 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.14160316 |
| 103 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.13510040 |
| 104 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.12808769 |
| 105 | Mineral absorption_Homo sapiens_hsa04978 | 0.12460388 |
| 106 | Shigellosis_Homo sapiens_hsa05131 | 0.11819688 |
| 107 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.11670530 |
| 108 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.11598797 |
| 109 | Lysosome_Homo sapiens_hsa04142 | 0.09794149 |
| 110 | Thyroid cancer_Homo sapiens_hsa05216 | 0.09757892 |
| 111 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.08911601 |
| 112 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.08811061 |
| 113 | Colorectal cancer_Homo sapiens_hsa05210 | 0.08765991 |
| 114 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.08636495 |
| 115 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.08486023 |
| 116 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.07902283 |
| 117 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.07509383 |
| 118 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.07149172 |
| 119 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.04638194 |
| 120 | Legionellosis_Homo sapiens_hsa05134 | 0.03792317 |
| 121 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.03761235 |
| 122 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.03565166 |
| 123 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.03202472 |
| 124 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.02117170 |
| 125 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.02090599 |
| 126 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.01247264 |
| 127 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.01184978 |
| 128 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.00996762 |
| 129 | Cardiac muscle contraction_Homo sapiens_hsa04260 | -0.0140277 |

