HPF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)5.02101603
2chromatin remodeling at centromere (GO:0031055)5.01109304
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.73597628
4proteasome assembly (GO:0043248)4.48187001
5chaperone-mediated protein transport (GO:0072321)4.20748882
6histone exchange (GO:0043486)4.15210923
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.14089349
8regulation of meiosis I (GO:0060631)4.04254120
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.98745526
10ATP synthesis coupled proton transport (GO:0015986)3.98745526
11DNA replication-independent nucleosome assembly (GO:0006336)3.93430735
12DNA replication-independent nucleosome organization (GO:0034724)3.93430735
13cullin deneddylation (GO:0010388)3.77073125
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.76661100
15protein complex biogenesis (GO:0070271)3.74731809
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.73276958
17exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70732442
18DNA replication checkpoint (GO:0000076)3.68150088
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.63256771
20NADH dehydrogenase complex assembly (GO:0010257)3.63256771
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63256771
22protein localization to kinetochore (GO:0034501)3.57121725
23mitochondrial respiratory chain complex assembly (GO:0033108)3.56077763
24respiratory electron transport chain (GO:0022904)3.53190149
25protein deneddylation (GO:0000338)3.53062291
26centriole replication (GO:0007099)3.50994319
27replication fork processing (GO:0031297)3.49408519
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.46960634
29kinetochore organization (GO:0051383)3.45458641
30electron transport chain (GO:0022900)3.45306605
31piRNA metabolic process (GO:0034587)3.38372099
32protein neddylation (GO:0045116)3.36531519
33DNA double-strand break processing (GO:0000729)3.36483307
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36119477
35regulation of mitotic spindle checkpoint (GO:1903504)3.36119477
36telomere maintenance via semi-conservative replication (GO:0032201)3.32567356
37kinetochore assembly (GO:0051382)3.32011289
38DNA replication-dependent nucleosome assembly (GO:0006335)3.26203415
39DNA replication-dependent nucleosome organization (GO:0034723)3.26203415
40establishment of integrated proviral latency (GO:0075713)3.25705423
41termination of RNA polymerase III transcription (GO:0006386)3.23726263
42transcription elongation from RNA polymerase III promoter (GO:0006385)3.23726263
43mitotic metaphase plate congression (GO:0007080)3.15677920
44resolution of meiotic recombination intermediates (GO:0000712)3.15575403
45DNA damage response, detection of DNA damage (GO:0042769)3.14423349
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13942663
47histone mRNA metabolic process (GO:0008334)3.13261401
48DNA strand elongation involved in DNA replication (GO:0006271)3.12888961
49synapsis (GO:0007129)3.12433470
50spliceosomal snRNP assembly (GO:0000387)3.11893205
51regulation of mitochondrial translation (GO:0070129)3.11304232
52retinal cone cell development (GO:0046549)3.10089814
53regulation of DNA methylation (GO:0044030)3.07113784
54meiotic cell cycle (GO:0051321)3.06676817
55postreplication repair (GO:0006301)3.06256562
56DNA strand elongation (GO:0022616)3.04747002
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04664212
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.02363432
59positive regulation of histone H3-K4 methylation (GO:0051571)2.98559854
60regulation of helicase activity (GO:0051095)2.97952375
61telomere maintenance via recombination (GO:0000722)2.97603248
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96689398
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94593645
64protein localization to chromosome, centromeric region (GO:0071459)2.90066683
65mitotic recombination (GO:0006312)2.89735909
66DNA ligation (GO:0006266)2.88772238
67translesion synthesis (GO:0019985)2.86818499
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85424553
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85424553
70metaphase plate congression (GO:0051310)2.85360391
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83679196
72transcription-coupled nucleotide-excision repair (GO:0006283)2.83483882
73attachment of spindle microtubules to kinetochore (GO:0008608)2.82959199
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80669502
75ribosomal small subunit assembly (GO:0000028)2.78877834
76protein K6-linked ubiquitination (GO:0085020)2.77468002
77respiratory chain complex IV assembly (GO:0008535)2.76615168
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69859145
79negative regulation of ligase activity (GO:0051352)2.69859145
80organelle disassembly (GO:1903008)2.68865241
81mismatch repair (GO:0006298)2.66902129
827-methylguanosine mRNA capping (GO:0006370)2.66329441
83telomere maintenance via telomere lengthening (GO:0010833)2.65449506
84purine nucleobase biosynthetic process (GO:0009113)2.65356147
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65101575
86cytochrome complex assembly (GO:0017004)2.63003758
87mitotic G2/M transition checkpoint (GO:0044818)2.62455255
88spindle checkpoint (GO:0031577)2.61400687
89transcription elongation from RNA polymerase I promoter (GO:0006362)2.60260997
90RNA capping (GO:0036260)2.59994919
917-methylguanosine RNA capping (GO:0009452)2.59994919
92termination of RNA polymerase I transcription (GO:0006363)2.59744637
93ribosomal large subunit biogenesis (GO:0042273)2.58939589
94protein-cofactor linkage (GO:0018065)2.58739321
95DNA catabolic process, exonucleolytic (GO:0000738)2.57813797
96chromatin assembly or disassembly (GO:0006333)2.57664873
97oxidative phosphorylation (GO:0006119)2.56986007
98water-soluble vitamin biosynthetic process (GO:0042364)2.56458251
99protein targeting to mitochondrion (GO:0006626)2.55976551
100pseudouridine synthesis (GO:0001522)2.55975469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.33938910
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32317468
3E2F7_22180533_ChIP-Seq_HELA_Human4.05326482
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.65719045
5EZH2_22144423_ChIP-Seq_EOC_Human3.53496224
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.42858609
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01595930
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82688628
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72103969
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69259846
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43089186
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40172395
13ELK1_19687146_ChIP-ChIP_HELA_Human2.39569396
14ZNF274_21170338_ChIP-Seq_K562_Hela2.36407222
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.35155411
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.33398263
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28908045
18EWS_26573619_Chip-Seq_HEK293_Human2.10874525
19VDR_23849224_ChIP-Seq_CD4+_Human2.09786670
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09368559
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05851170
22FUS_26573619_Chip-Seq_HEK293_Human1.98285306
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92439683
24FOXP3_21729870_ChIP-Seq_TREG_Human1.91752141
25VDR_22108803_ChIP-Seq_LS180_Human1.91034336
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.90493233
27IGF1R_20145208_ChIP-Seq_DFB_Human1.80203333
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76638357
29MYC_18940864_ChIP-ChIP_HL60_Human1.73007157
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72046327
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63650363
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59399578
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59192193
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58938242
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51789450
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49971107
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49142727
38TAF15_26573619_Chip-Seq_HEK293_Human1.46817919
39P300_19829295_ChIP-Seq_ESCs_Human1.46789084
40GBX2_23144817_ChIP-Seq_PC3_Human1.46750820
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46324627
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.45667040
43IRF1_19129219_ChIP-ChIP_H3396_Human1.45361510
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.45248174
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45218620
46DCP1A_22483619_ChIP-Seq_HELA_Human1.44831667
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42510446
48TTF2_22483619_ChIP-Seq_HELA_Human1.39812761
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.36545229
50GABP_19822575_ChIP-Seq_HepG2_Human1.34793257
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32967952
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32758246
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31790406
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30977255
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30477565
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30372772
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28082615
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27387316
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27310423
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26657046
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26497868
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.24841445
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19864642
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.18954972
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18421786
66AR_21909140_ChIP-Seq_LNCAP_Human1.18151688
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16319756
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13858672
69TP53_22573176_ChIP-Seq_HFKS_Human1.11973850
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11586865
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.09384801
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07388540
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06919313
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06497293
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06194013
76CBP_20019798_ChIP-Seq_JUKART_Human1.06114605
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06114605
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06059923
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05635886
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.03001181
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02797910
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02714745
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00763875
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00454650
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99565439
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.99487628
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.98890847
88HTT_18923047_ChIP-ChIP_STHdh_Human0.97116034
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96736055
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92810327
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91150039
92XRN2_22483619_ChIP-Seq_HELA_Human0.90951666
93RNF2_27304074_Chip-Seq_NSC_Mouse0.90732382
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90575034
95ER_23166858_ChIP-Seq_MCF-7_Human0.90472120
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.89681792
97NANOG_19829295_ChIP-Seq_ESCs_Human0.89143946
98SOX2_19829295_ChIP-Seq_ESCs_Human0.89143946
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88769565
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88634596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.17476053
2MP0003718_maternal_effect3.78682888
3MP0008877_abnormal_DNA_methylation3.58031888
4MP0008058_abnormal_DNA_repair3.20245579
5MP0008789_abnormal_olfactory_epithelium3.04426729
6MP0010094_abnormal_chromosome_stability2.83236180
7MP0001529_abnormal_vocalization2.60235585
8MP0005394_taste/olfaction_phenotype2.52595512
9MP0005499_abnormal_olfactory_system2.52595512
10MP0003693_abnormal_embryo_hatching2.44283367
11MP0002102_abnormal_ear_morphology2.33408913
12MP0008057_abnormal_DNA_replication2.25481365
13MP0003121_genomic_imprinting2.21453306
14MP0009379_abnormal_foot_pigmentation2.09680964
15MP0002234_abnormal_pharynx_morphology2.09474591
16MP0003787_abnormal_imprinting1.99634739
17MP0001293_anophthalmia1.95969671
18MP0003880_abnormal_central_pattern1.92710710
19MP0003111_abnormal_nucleus_morphology1.84639831
20MP0004957_abnormal_blastocyst_morpholog1.84006701
21MP0003077_abnormal_cell_cycle1.83998537
22MP0006072_abnormal_retinal_apoptosis1.81667697
23MP0008932_abnormal_embryonic_tissue1.78437570
24MP0003890_abnormal_embryonic-extraembry1.75477811
25MP0001984_abnormal_olfaction1.71895078
26MP0002210_abnormal_sex_determination1.55040628
27MP0010030_abnormal_orbit_morphology1.55006017
28MP0002938_white_spotting1.54988339
29MP0000631_abnormal_neuroendocrine_gland1.53128771
30MP0005646_abnormal_pituitary_gland1.45022421
31MP0004142_abnormal_muscle_tone1.43847021
32MP0008995_early_reproductive_senescence1.42439083
33MP0002233_abnormal_nose_morphology1.41497271
34MP0003122_maternal_imprinting1.40181262
35MP0001929_abnormal_gametogenesis1.39597351
36MP0000049_abnormal_middle_ear1.39504972
37MP0005551_abnormal_eye_electrophysiolog1.36789409
38MP0006276_abnormal_autonomic_nervous1.36448653
39MP0003786_premature_aging1.35794737
40MP0002638_abnormal_pupillary_reflex1.35218140
41MP0009697_abnormal_copulation1.31880697
42MP0003186_abnormal_redox_activity1.31197787
43MP0002272_abnormal_nervous_system1.28080725
44MP0000653_abnormal_sex_gland1.25407800
45MP0005395_other_phenotype1.24319608
46MP0002751_abnormal_autonomic_nervous1.21296477
47MP0002160_abnormal_reproductive_system1.20883122
48MP0000372_irregular_coat_pigmentation1.20863972
49MP0001145_abnormal_male_reproductive1.17438716
50MP0002736_abnormal_nociception_after1.16186355
51MP0005645_abnormal_hypothalamus_physiol1.14752962
52MP0005253_abnormal_eye_physiology1.14612112
53MP0003119_abnormal_digestive_system1.09151971
54MP0006036_abnormal_mitochondrial_physio1.08310644
55MP0003567_abnormal_fetal_cardiomyocyte1.07939479
56MP0003937_abnormal_limbs/digits/tail_de1.05702769
57MP0003698_abnormal_male_reproductive1.03204767
58MP0003136_yellow_coat_color1.03112290
59MP0000778_abnormal_nervous_system1.01745331
60MP0001188_hyperpigmentation1.01121854
61MP0001485_abnormal_pinna_reflex1.00147777
62MP0009046_muscle_twitch0.99616268
63MP0005389_reproductive_system_phenotype0.98596669
64MP0001286_abnormal_eye_development0.97809464
65MP0006035_abnormal_mitochondrial_morpho0.96298982
66MP0001486_abnormal_startle_reflex0.96143175
67MP0001968_abnormal_touch/_nociception0.95820694
68MP0009745_abnormal_behavioral_response0.94931977
69MP0008007_abnormal_cellular_replicative0.94196742
70MP0003941_abnormal_skin_development0.92477503
71MP0004133_heterotaxia0.90004858
72MP0004147_increased_porphyrin_level0.87316855
73MP0002734_abnormal_mechanical_nocicepti0.86256202
74MP0003806_abnormal_nucleotide_metabolis0.85146880
75MP0002735_abnormal_chemical_nociception0.85015733
76MP0002161_abnormal_fertility/fecundity0.82711044
77MP0003938_abnormal_ear_development0.82692753
78MP0001119_abnormal_female_reproductive0.82387029
79MP0002277_abnormal_respiratory_mucosa0.82000066
80MP0002752_abnormal_somatic_nervous0.80637186
81MP0001986_abnormal_taste_sensitivity0.79824913
82MP0005410_abnormal_fertilization0.78936587
83MP0003699_abnormal_female_reproductive0.78860406
84MP0000647_abnormal_sebaceous_gland0.76963632
85MP0005391_vision/eye_phenotype0.76837315
86MP0004145_abnormal_muscle_electrophysio0.76556844
87MP0004742_abnormal_vestibular_system0.75825371
88MP0000427_abnormal_hair_cycle0.75643516
89MP0001764_abnormal_homeostasis0.75615537
90MP0004270_analgesia0.75160593
91MP0005084_abnormal_gallbladder_morpholo0.75080380
92MP0005195_abnormal_posterior_eye0.74965528
93MP0001905_abnormal_dopamine_level0.74868468
94MP0004215_abnormal_myocardial_fiber0.74689016
95MP0003755_abnormal_palate_morphology0.73330061
96MP0003635_abnormal_synaptic_transmissio0.73130499
97MP0002090_abnormal_vision0.72988951
98MP0002557_abnormal_social/conspecific_i0.70791237
99MP0002572_abnormal_emotion/affect_behav0.70413828
100MP0003861_abnormal_nervous_system0.70291128

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.24438346
2Abnormal mitochondria in muscle tissue (HP:0008316)3.79312347
3Acute encephalopathy (HP:0006846)3.77288682
4Abnormality of the labia minora (HP:0012880)3.64755878
5Progressive macrocephaly (HP:0004481)3.62500971
6Mitochondrial inheritance (HP:0001427)3.62428305
7Increased hepatocellular lipid droplets (HP:0006565)3.39899214
8Increased CSF lactate (HP:0002490)3.35995499
9Abnormality of midbrain morphology (HP:0002418)3.09931097
10Molar tooth sign on MRI (HP:0002419)3.09931097
11Hepatocellular necrosis (HP:0001404)3.02629120
12Lipid accumulation in hepatocytes (HP:0006561)3.00048366
13Septo-optic dysplasia (HP:0100842)2.94930818
14Hepatic necrosis (HP:0002605)2.89240219
15Colon cancer (HP:0003003)2.89016813
16Volvulus (HP:0002580)2.87978310
17Chromsome breakage (HP:0040012)2.85408554
18Renal Fanconi syndrome (HP:0001994)2.83431771
19Pancreatic fibrosis (HP:0100732)2.82711839
20Cerebral edema (HP:0002181)2.82704876
21Methylmalonic acidemia (HP:0002912)2.81929402
223-Methylglutaconic aciduria (HP:0003535)2.80456447
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76126800
24Supernumerary spleens (HP:0009799)2.72843921
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.67873836
26Meckel diverticulum (HP:0002245)2.66867427
27Medial flaring of the eyebrow (HP:0010747)2.63602944
28Abnormality of the ileum (HP:0001549)2.63430602
29Pancreatic cysts (HP:0001737)2.62280113
30Abnormality of chromosome stability (HP:0003220)2.55818844
31True hermaphroditism (HP:0010459)2.49485432
32Hyperglycinemia (HP:0002154)2.39792504
33Abnormal lung lobation (HP:0002101)2.38511705
34Reticulocytopenia (HP:0001896)2.38059994
35Median cleft lip (HP:0000161)2.30202924
36Nephronophthisis (HP:0000090)2.28767377
37Gait imbalance (HP:0002141)2.21854265
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21312445
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21312445
40Increased serum lactate (HP:0002151)2.20896499
41Absent septum pellucidum (HP:0001331)2.19986568
42Abnormality of the preputium (HP:0100587)2.19847002
43Congenital primary aphakia (HP:0007707)2.18126819
44Bifid tongue (HP:0010297)2.17657996
45Increased intramyocellular lipid droplets (HP:0012240)2.17301295
46Methylmalonic aciduria (HP:0012120)2.16624676
47Macrocytic anemia (HP:0001972)2.14785923
48Lactic acidosis (HP:0003128)2.14542592
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.12328945
50Short tibia (HP:0005736)2.10524906
51Triphalangeal thumb (HP:0001199)2.10115366
52Optic disc pallor (HP:0000543)2.09096550
53Oligodactyly (hands) (HP:0001180)2.06968295
54Myokymia (HP:0002411)2.04447034
55Optic nerve hypoplasia (HP:0000609)2.04268606
56Small intestinal stenosis (HP:0012848)2.04247153
57Duodenal stenosis (HP:0100867)2.04247153
58Nephrogenic diabetes insipidus (HP:0009806)2.04226485
59Bile duct proliferation (HP:0001408)2.03357599
60Abnormal biliary tract physiology (HP:0012439)2.03357599
61Genital tract atresia (HP:0001827)2.02390086
62Leukodystrophy (HP:0002415)1.97264838
63Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95383154
64Gonadotropin excess (HP:0000837)1.93741894
65Respiratory failure (HP:0002878)1.93590715
66Aplasia/Hypoplasia of the tibia (HP:0005772)1.92482721
67Exertional dyspnea (HP:0002875)1.92134782
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90826907
69Aplastic anemia (HP:0001915)1.88668575
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88491237
71Megaloblastic anemia (HP:0001889)1.88019402
72Intestinal atresia (HP:0011100)1.86655745
73Abnormality of the duodenum (HP:0002246)1.86228479
74Vaginal atresia (HP:0000148)1.84883662
75Abnormality of the septum pellucidum (HP:0007375)1.84729210
76Facial hemangioma (HP:0000329)1.83019849
77Abnormal number of erythroid precursors (HP:0012131)1.82815337
78Abnormality of methionine metabolism (HP:0010901)1.82428372
79Sclerocornea (HP:0000647)1.82296193
80Hypoplasia of the fovea (HP:0007750)1.82204586
81Aplasia/Hypoplasia of the fovea (HP:0008060)1.82204586
82Exercise intolerance (HP:0003546)1.81811340
83Oligodactyly (HP:0012165)1.81270580
84Absent thumb (HP:0009777)1.80330703
85Abnormality of the fovea (HP:0000493)1.79689155
86Abnormality of the renal medulla (HP:0100957)1.78964616
87Postaxial hand polydactyly (HP:0001162)1.76711058
88Abnormality of renal resorption (HP:0011038)1.74862377
89Abnormality of cells of the erythroid lineage (HP:0012130)1.74044356
90Abnormality of the anterior horn cell (HP:0006802)1.73393656
91Degeneration of anterior horn cells (HP:0002398)1.73393656
92Pendular nystagmus (HP:0012043)1.71721028
93Renal cortical cysts (HP:0000803)1.71168943
94Microvesicular hepatic steatosis (HP:0001414)1.70742834
95Postaxial foot polydactyly (HP:0001830)1.69461258
96Increased serum pyruvate (HP:0003542)1.68938212
97Type I transferrin isoform profile (HP:0003642)1.67514234
98Lethargy (HP:0001254)1.67503042
99Abnormality of urine glucose concentration (HP:0011016)1.67478900
100Glycosuria (HP:0003076)1.67478900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.30306192
2BUB12.99173657
3WNK32.90460890
4VRK22.71877269
5TRIM282.51490922
6NUAK12.39481679
7ZAK2.22422837
8TTK2.14602883
9MAP4K22.11690653
10SRPK12.08084197
11PBK2.08060780
12STK162.03684631
13TNIK1.96306967
14VRK11.96102632
15PLK31.91488542
16EIF2AK31.89976167
17PLK41.86980923
18NEK11.78427791
19CASK1.73754668
20MST41.73534980
21BMPR1B1.63995419
22DYRK21.53588029
23WEE11.51279090
24EIF2AK11.50224386
25PLK11.49499506
26MAP3K41.48709692
27MAPK131.43736287
28BCR1.38416001
29CSNK1G11.35005577
30MKNK11.34222329
31CSNK1G21.31898914
32CSNK1G31.29870486
33MAP2K71.26584656
34BCKDK1.22755085
35MKNK21.18330822
36CDK191.18248625
37FRK1.16683015
38BRSK21.15467713
39NME11.14184303
40TAF11.13641468
41TLK11.09130627
42PNCK1.09045617
43MARK11.07031369
44NEK21.02138264
45MAP3K91.00539343
46MAP3K120.97895743
47TSSK60.97818737
48ATR0.97528710
49CSNK1A1L0.96947147
50AURKA0.96678352
51TAOK30.94723754
52CHEK20.93374859
53ACVR1B0.92451010
54ERBB30.91412518
55CCNB10.89141356
56PLK20.88582977
57ARAF0.86477336
58AURKB0.84488331
59GRK10.84100450
60OXSR10.83331579
61STK390.81285083
62RPS6KA40.80535214
63PINK10.79760523
64DYRK30.79314168
65BRSK10.76987556
66ATM0.75100657
67EPHA40.70960283
68ADRBK20.69889251
69STK30.67864177
70NTRK20.66040940
71INSRR0.65947043
72EIF2AK20.62921606
73MINK10.61128250
74PRKCG0.59925941
75CSNK2A20.59657361
76CHEK10.58329378
77CSNK2A10.57114430
78CSNK1E0.53678410
79PKN10.50503519
80CDK30.50233780
81STK38L0.50053725
82TIE10.49454886
83CDK80.49028666
84PASK0.47551036
85BRAF0.46695516
86CAMK2A0.45024371
87PRKCE0.45007820
88LIMK10.44438142
89NEK60.42835076
90CDK90.41375289
91UHMK10.41097377
92CDK20.40089730
93STK240.39671712
94PDK20.39661881
95CDK140.39596294
96CSNK1D0.39388599
97CSNK1A10.39375533
98WNK40.39348922
99CDK10.39228514
100CDK70.39190454

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.51592493
2Mismatch repair_Homo sapiens_hsa034303.51514633
3Proteasome_Homo sapiens_hsa030503.33444647
4Protein export_Homo sapiens_hsa030603.24782110
5Parkinsons disease_Homo sapiens_hsa050123.08033269
6DNA replication_Homo sapiens_hsa030302.97200938
7Homologous recombination_Homo sapiens_hsa034402.89760223
8Ribosome_Homo sapiens_hsa030102.89224139
9RNA polymerase_Homo sapiens_hsa030202.71420791
10Basal transcription factors_Homo sapiens_hsa030222.50593452
11Fanconi anemia pathway_Homo sapiens_hsa034602.47607607
12Huntingtons disease_Homo sapiens_hsa050162.30080843
13Base excision repair_Homo sapiens_hsa034102.28186998
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20235779
15Nucleotide excision repair_Homo sapiens_hsa034202.19025535
16RNA degradation_Homo sapiens_hsa030182.11979647
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05842880
18Non-homologous end-joining_Homo sapiens_hsa034502.05709766
19Alzheimers disease_Homo sapiens_hsa050101.94372257
20Spliceosome_Homo sapiens_hsa030401.94248512
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75794991
22RNA transport_Homo sapiens_hsa030131.71137525
23Propanoate metabolism_Homo sapiens_hsa006401.71062966
24Cell cycle_Homo sapiens_hsa041101.70075984
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48554298
26Folate biosynthesis_Homo sapiens_hsa007901.47331590
27Pyrimidine metabolism_Homo sapiens_hsa002401.47277893
28Cardiac muscle contraction_Homo sapiens_hsa042601.45721177
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.44088583
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43487046
31One carbon pool by folate_Homo sapiens_hsa006701.32497488
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24784661
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23571250
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23324528
35Purine metabolism_Homo sapiens_hsa002301.23219525
36Oocyte meiosis_Homo sapiens_hsa041141.19246871
37Pyruvate metabolism_Homo sapiens_hsa006201.18499521
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16500005
39Fatty acid elongation_Homo sapiens_hsa000621.15301169
40Steroid biosynthesis_Homo sapiens_hsa001001.14394865
41Phototransduction_Homo sapiens_hsa047441.11110198
42Butanoate metabolism_Homo sapiens_hsa006501.08356303
43Nicotine addiction_Homo sapiens_hsa050331.04348683
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97602543
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84128786
46Glutathione metabolism_Homo sapiens_hsa004800.79871204
47Caffeine metabolism_Homo sapiens_hsa002320.79041076
48mRNA surveillance pathway_Homo sapiens_hsa030150.73084133
49Metabolic pathways_Homo sapiens_hsa011000.72179966
50Olfactory transduction_Homo sapiens_hsa047400.70701574
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69496962
52Peroxisome_Homo sapiens_hsa041460.69312148
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63997626
54Selenocompound metabolism_Homo sapiens_hsa004500.59174530
55Vitamin B6 metabolism_Homo sapiens_hsa007500.58689260
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58377311
57Taste transduction_Homo sapiens_hsa047420.57479492
58Regulation of autophagy_Homo sapiens_hsa041400.56296916
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53136410
60Collecting duct acid secretion_Homo sapiens_hsa049660.52613086
61p53 signaling pathway_Homo sapiens_hsa041150.51718401
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51654520
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50338028
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.50254747
65GABAergic synapse_Homo sapiens_hsa047270.47227318
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45285816
67beta-Alanine metabolism_Homo sapiens_hsa004100.43337123
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41858925
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41468478
70Nitrogen metabolism_Homo sapiens_hsa009100.40585444
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39847027
72Tryptophan metabolism_Homo sapiens_hsa003800.38978490
73Carbon metabolism_Homo sapiens_hsa012000.38961057
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38329866
75Chemical carcinogenesis_Homo sapiens_hsa052040.37592862
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36757030
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36169280
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35647786
79Morphine addiction_Homo sapiens_hsa050320.35147708
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35095265
81Retinol metabolism_Homo sapiens_hsa008300.31802434
82Sulfur relay system_Homo sapiens_hsa041220.30140329
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.29700266
84Hedgehog signaling pathway_Homo sapiens_hsa043400.29479334
85Circadian rhythm_Homo sapiens_hsa047100.29054035
86Fatty acid metabolism_Homo sapiens_hsa012120.28589914
87Biosynthesis of amino acids_Homo sapiens_hsa012300.28186752
88Arginine and proline metabolism_Homo sapiens_hsa003300.27812568
89Fatty acid degradation_Homo sapiens_hsa000710.27225721
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26998059
91Basal cell carcinoma_Homo sapiens_hsa052170.26778010
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.25717015
93TGF-beta signaling pathway_Homo sapiens_hsa043500.24967608
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24285787
95Linoleic acid metabolism_Homo sapiens_hsa005910.23800743
96Wnt signaling pathway_Homo sapiens_hsa043100.23054172
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21644936
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20586452
99Ether lipid metabolism_Homo sapiens_hsa005650.20049050
100Serotonergic synapse_Homo sapiens_hsa047260.18829532

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