

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CENP-A containing nucleosome assembly (GO:0034080) | 5.02101603 |
| 2 | chromatin remodeling at centromere (GO:0031055) | 5.01109304 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.73597628 |
| 4 | proteasome assembly (GO:0043248) | 4.48187001 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.20748882 |
| 6 | histone exchange (GO:0043486) | 4.15210923 |
| 7 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.14089349 |
| 8 | regulation of meiosis I (GO:0060631) | 4.04254120 |
| 9 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.98745526 |
| 10 | ATP synthesis coupled proton transport (GO:0015986) | 3.98745526 |
| 11 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.93430735 |
| 12 | DNA replication-independent nucleosome organization (GO:0034724) | 3.93430735 |
| 13 | cullin deneddylation (GO:0010388) | 3.77073125 |
| 14 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.76661100 |
| 15 | protein complex biogenesis (GO:0070271) | 3.74731809 |
| 16 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.73276958 |
| 17 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.70732442 |
| 18 | DNA replication checkpoint (GO:0000076) | 3.68150088 |
| 19 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.63256771 |
| 20 | NADH dehydrogenase complex assembly (GO:0010257) | 3.63256771 |
| 21 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.63256771 |
| 22 | protein localization to kinetochore (GO:0034501) | 3.57121725 |
| 23 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.56077763 |
| 24 | respiratory electron transport chain (GO:0022904) | 3.53190149 |
| 25 | protein deneddylation (GO:0000338) | 3.53062291 |
| 26 | centriole replication (GO:0007099) | 3.50994319 |
| 27 | replication fork processing (GO:0031297) | 3.49408519 |
| 28 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.46960634 |
| 29 | kinetochore organization (GO:0051383) | 3.45458641 |
| 30 | electron transport chain (GO:0022900) | 3.45306605 |
| 31 | piRNA metabolic process (GO:0034587) | 3.38372099 |
| 32 | protein neddylation (GO:0045116) | 3.36531519 |
| 33 | DNA double-strand break processing (GO:0000729) | 3.36483307 |
| 34 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.36119477 |
| 35 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.36119477 |
| 36 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.32567356 |
| 37 | kinetochore assembly (GO:0051382) | 3.32011289 |
| 38 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.26203415 |
| 39 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.26203415 |
| 40 | establishment of integrated proviral latency (GO:0075713) | 3.25705423 |
| 41 | termination of RNA polymerase III transcription (GO:0006386) | 3.23726263 |
| 42 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.23726263 |
| 43 | mitotic metaphase plate congression (GO:0007080) | 3.15677920 |
| 44 | resolution of meiotic recombination intermediates (GO:0000712) | 3.15575403 |
| 45 | DNA damage response, detection of DNA damage (GO:0042769) | 3.14423349 |
| 46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.13942663 |
| 47 | histone mRNA metabolic process (GO:0008334) | 3.13261401 |
| 48 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.12888961 |
| 49 | synapsis (GO:0007129) | 3.12433470 |
| 50 | spliceosomal snRNP assembly (GO:0000387) | 3.11893205 |
| 51 | regulation of mitochondrial translation (GO:0070129) | 3.11304232 |
| 52 | retinal cone cell development (GO:0046549) | 3.10089814 |
| 53 | regulation of DNA methylation (GO:0044030) | 3.07113784 |
| 54 | meiotic cell cycle (GO:0051321) | 3.06676817 |
| 55 | postreplication repair (GO:0006301) | 3.06256562 |
| 56 | DNA strand elongation (GO:0022616) | 3.04747002 |
| 57 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.04664212 |
| 58 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.02363432 |
| 59 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.98559854 |
| 60 | regulation of helicase activity (GO:0051095) | 2.97952375 |
| 61 | telomere maintenance via recombination (GO:0000722) | 2.97603248 |
| 62 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.96689398 |
| 63 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.94593645 |
| 64 | protein localization to chromosome, centromeric region (GO:0071459) | 2.90066683 |
| 65 | mitotic recombination (GO:0006312) | 2.89735909 |
| 66 | DNA ligation (GO:0006266) | 2.88772238 |
| 67 | translesion synthesis (GO:0019985) | 2.86818499 |
| 68 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.85424553 |
| 69 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.85424553 |
| 70 | metaphase plate congression (GO:0051310) | 2.85360391 |
| 71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.83679196 |
| 72 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.83483882 |
| 73 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.82959199 |
| 74 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.80669502 |
| 75 | ribosomal small subunit assembly (GO:0000028) | 2.78877834 |
| 76 | protein K6-linked ubiquitination (GO:0085020) | 2.77468002 |
| 77 | respiratory chain complex IV assembly (GO:0008535) | 2.76615168 |
| 78 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.69859145 |
| 79 | negative regulation of ligase activity (GO:0051352) | 2.69859145 |
| 80 | organelle disassembly (GO:1903008) | 2.68865241 |
| 81 | mismatch repair (GO:0006298) | 2.66902129 |
| 82 | 7-methylguanosine mRNA capping (GO:0006370) | 2.66329441 |
| 83 | telomere maintenance via telomere lengthening (GO:0010833) | 2.65449506 |
| 84 | purine nucleobase biosynthetic process (GO:0009113) | 2.65356147 |
| 85 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.65101575 |
| 86 | cytochrome complex assembly (GO:0017004) | 2.63003758 |
| 87 | mitotic G2/M transition checkpoint (GO:0044818) | 2.62455255 |
| 88 | spindle checkpoint (GO:0031577) | 2.61400687 |
| 89 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.60260997 |
| 90 | RNA capping (GO:0036260) | 2.59994919 |
| 91 | 7-methylguanosine RNA capping (GO:0009452) | 2.59994919 |
| 92 | termination of RNA polymerase I transcription (GO:0006363) | 2.59744637 |
| 93 | ribosomal large subunit biogenesis (GO:0042273) | 2.58939589 |
| 94 | protein-cofactor linkage (GO:0018065) | 2.58739321 |
| 95 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.57813797 |
| 96 | chromatin assembly or disassembly (GO:0006333) | 2.57664873 |
| 97 | oxidative phosphorylation (GO:0006119) | 2.56986007 |
| 98 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.56458251 |
| 99 | protein targeting to mitochondrion (GO:0006626) | 2.55976551 |
| 100 | pseudouridine synthesis (GO:0001522) | 2.55975469 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.33938910 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.32317468 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.05326482 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.65719045 |
| 5 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.53496224 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.42858609 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.01595930 |
| 8 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.82688628 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.72103969 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.69259846 |
| 11 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.43089186 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.40172395 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.39569396 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.36407222 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.35155411 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.33398263 |
| 17 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.28908045 |
| 18 | EWS_26573619_Chip-Seq_HEK293_Human | 2.10874525 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.09786670 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.09368559 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.05851170 |
| 22 | FUS_26573619_Chip-Seq_HEK293_Human | 1.98285306 |
| 23 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.92439683 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.91752141 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 1.91034336 |
| 26 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.90493233 |
| 27 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.80203333 |
| 28 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.76638357 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.73007157 |
| 30 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.72046327 |
| 31 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.63650363 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.59399578 |
| 33 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.59192193 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.58938242 |
| 35 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.51789450 |
| 36 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.49971107 |
| 37 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.49142727 |
| 38 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.46817919 |
| 39 | P300_19829295_ChIP-Seq_ESCs_Human | 1.46789084 |
| 40 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.46750820 |
| 41 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.46324627 |
| 42 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.45667040 |
| 43 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.45361510 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.45248174 |
| 45 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.45218620 |
| 46 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.44831667 |
| 47 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.42510446 |
| 48 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.39812761 |
| 49 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.36545229 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.34793257 |
| 51 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.32967952 |
| 52 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.32758246 |
| 53 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.31790406 |
| 54 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.30977255 |
| 55 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.30477565 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.30372772 |
| 57 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.28082615 |
| 58 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.27387316 |
| 59 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.27310423 |
| 60 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.26657046 |
| 61 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.26497868 |
| 62 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.24841445 |
| 63 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.19864642 |
| 64 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.18954972 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.18421786 |
| 66 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.18151688 |
| 67 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.16319756 |
| 68 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.13858672 |
| 69 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11973850 |
| 70 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.11586865 |
| 71 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.09384801 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07388540 |
| 73 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.06919313 |
| 74 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.06497293 |
| 75 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.06194013 |
| 76 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.06114605 |
| 77 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.06114605 |
| 78 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.06059923 |
| 79 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.05635886 |
| 80 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.03001181 |
| 81 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.02797910 |
| 82 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.02714745 |
| 83 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.00763875 |
| 84 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.00454650 |
| 85 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.99565439 |
| 86 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.99487628 |
| 87 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.98890847 |
| 88 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.97116034 |
| 89 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96736055 |
| 90 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.92810327 |
| 91 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.91150039 |
| 92 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.90951666 |
| 93 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.90732382 |
| 94 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.90575034 |
| 95 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.90472120 |
| 96 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.89681792 |
| 97 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.89143946 |
| 98 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.89143946 |
| 99 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.88769565 |
| 100 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.88634596 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 4.17476053 |
| 2 | MP0003718_maternal_effect | 3.78682888 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.58031888 |
| 4 | MP0008058_abnormal_DNA_repair | 3.20245579 |
| 5 | MP0008789_abnormal_olfactory_epithelium | 3.04426729 |
| 6 | MP0010094_abnormal_chromosome_stability | 2.83236180 |
| 7 | MP0001529_abnormal_vocalization | 2.60235585 |
| 8 | MP0005394_taste/olfaction_phenotype | 2.52595512 |
| 9 | MP0005499_abnormal_olfactory_system | 2.52595512 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.44283367 |
| 11 | MP0002102_abnormal_ear_morphology | 2.33408913 |
| 12 | MP0008057_abnormal_DNA_replication | 2.25481365 |
| 13 | MP0003121_genomic_imprinting | 2.21453306 |
| 14 | MP0009379_abnormal_foot_pigmentation | 2.09680964 |
| 15 | MP0002234_abnormal_pharynx_morphology | 2.09474591 |
| 16 | MP0003787_abnormal_imprinting | 1.99634739 |
| 17 | MP0001293_anophthalmia | 1.95969671 |
| 18 | MP0003880_abnormal_central_pattern | 1.92710710 |
| 19 | MP0003111_abnormal_nucleus_morphology | 1.84639831 |
| 20 | MP0004957_abnormal_blastocyst_morpholog | 1.84006701 |
| 21 | MP0003077_abnormal_cell_cycle | 1.83998537 |
| 22 | MP0006072_abnormal_retinal_apoptosis | 1.81667697 |
| 23 | MP0008932_abnormal_embryonic_tissue | 1.78437570 |
| 24 | MP0003890_abnormal_embryonic-extraembry | 1.75477811 |
| 25 | MP0001984_abnormal_olfaction | 1.71895078 |
| 26 | MP0002210_abnormal_sex_determination | 1.55040628 |
| 27 | MP0010030_abnormal_orbit_morphology | 1.55006017 |
| 28 | MP0002938_white_spotting | 1.54988339 |
| 29 | MP0000631_abnormal_neuroendocrine_gland | 1.53128771 |
| 30 | MP0005646_abnormal_pituitary_gland | 1.45022421 |
| 31 | MP0004142_abnormal_muscle_tone | 1.43847021 |
| 32 | MP0008995_early_reproductive_senescence | 1.42439083 |
| 33 | MP0002233_abnormal_nose_morphology | 1.41497271 |
| 34 | MP0003122_maternal_imprinting | 1.40181262 |
| 35 | MP0001929_abnormal_gametogenesis | 1.39597351 |
| 36 | MP0000049_abnormal_middle_ear | 1.39504972 |
| 37 | MP0005551_abnormal_eye_electrophysiolog | 1.36789409 |
| 38 | MP0006276_abnormal_autonomic_nervous | 1.36448653 |
| 39 | MP0003786_premature_aging | 1.35794737 |
| 40 | MP0002638_abnormal_pupillary_reflex | 1.35218140 |
| 41 | MP0009697_abnormal_copulation | 1.31880697 |
| 42 | MP0003186_abnormal_redox_activity | 1.31197787 |
| 43 | MP0002272_abnormal_nervous_system | 1.28080725 |
| 44 | MP0000653_abnormal_sex_gland | 1.25407800 |
| 45 | MP0005395_other_phenotype | 1.24319608 |
| 46 | MP0002751_abnormal_autonomic_nervous | 1.21296477 |
| 47 | MP0002160_abnormal_reproductive_system | 1.20883122 |
| 48 | MP0000372_irregular_coat_pigmentation | 1.20863972 |
| 49 | MP0001145_abnormal_male_reproductive | 1.17438716 |
| 50 | MP0002736_abnormal_nociception_after | 1.16186355 |
| 51 | MP0005645_abnormal_hypothalamus_physiol | 1.14752962 |
| 52 | MP0005253_abnormal_eye_physiology | 1.14612112 |
| 53 | MP0003119_abnormal_digestive_system | 1.09151971 |
| 54 | MP0006036_abnormal_mitochondrial_physio | 1.08310644 |
| 55 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07939479 |
| 56 | MP0003937_abnormal_limbs/digits/tail_de | 1.05702769 |
| 57 | MP0003698_abnormal_male_reproductive | 1.03204767 |
| 58 | MP0003136_yellow_coat_color | 1.03112290 |
| 59 | MP0000778_abnormal_nervous_system | 1.01745331 |
| 60 | MP0001188_hyperpigmentation | 1.01121854 |
| 61 | MP0001485_abnormal_pinna_reflex | 1.00147777 |
| 62 | MP0009046_muscle_twitch | 0.99616268 |
| 63 | MP0005389_reproductive_system_phenotype | 0.98596669 |
| 64 | MP0001286_abnormal_eye_development | 0.97809464 |
| 65 | MP0006035_abnormal_mitochondrial_morpho | 0.96298982 |
| 66 | MP0001486_abnormal_startle_reflex | 0.96143175 |
| 67 | MP0001968_abnormal_touch/_nociception | 0.95820694 |
| 68 | MP0009745_abnormal_behavioral_response | 0.94931977 |
| 69 | MP0008007_abnormal_cellular_replicative | 0.94196742 |
| 70 | MP0003941_abnormal_skin_development | 0.92477503 |
| 71 | MP0004133_heterotaxia | 0.90004858 |
| 72 | MP0004147_increased_porphyrin_level | 0.87316855 |
| 73 | MP0002734_abnormal_mechanical_nocicepti | 0.86256202 |
| 74 | MP0003806_abnormal_nucleotide_metabolis | 0.85146880 |
| 75 | MP0002735_abnormal_chemical_nociception | 0.85015733 |
| 76 | MP0002161_abnormal_fertility/fecundity | 0.82711044 |
| 77 | MP0003938_abnormal_ear_development | 0.82692753 |
| 78 | MP0001119_abnormal_female_reproductive | 0.82387029 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 0.82000066 |
| 80 | MP0002752_abnormal_somatic_nervous | 0.80637186 |
| 81 | MP0001986_abnormal_taste_sensitivity | 0.79824913 |
| 82 | MP0005410_abnormal_fertilization | 0.78936587 |
| 83 | MP0003699_abnormal_female_reproductive | 0.78860406 |
| 84 | MP0000647_abnormal_sebaceous_gland | 0.76963632 |
| 85 | MP0005391_vision/eye_phenotype | 0.76837315 |
| 86 | MP0004145_abnormal_muscle_electrophysio | 0.76556844 |
| 87 | MP0004742_abnormal_vestibular_system | 0.75825371 |
| 88 | MP0000427_abnormal_hair_cycle | 0.75643516 |
| 89 | MP0001764_abnormal_homeostasis | 0.75615537 |
| 90 | MP0004270_analgesia | 0.75160593 |
| 91 | MP0005084_abnormal_gallbladder_morpholo | 0.75080380 |
| 92 | MP0005195_abnormal_posterior_eye | 0.74965528 |
| 93 | MP0001905_abnormal_dopamine_level | 0.74868468 |
| 94 | MP0004215_abnormal_myocardial_fiber | 0.74689016 |
| 95 | MP0003755_abnormal_palate_morphology | 0.73330061 |
| 96 | MP0003635_abnormal_synaptic_transmissio | 0.73130499 |
| 97 | MP0002090_abnormal_vision | 0.72988951 |
| 98 | MP0002557_abnormal_social/conspecific_i | 0.70791237 |
| 99 | MP0002572_abnormal_emotion/affect_behav | 0.70413828 |
| 100 | MP0003861_abnormal_nervous_system | 0.70291128 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.24438346 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.79312347 |
| 3 | Acute encephalopathy (HP:0006846) | 3.77288682 |
| 4 | Abnormality of the labia minora (HP:0012880) | 3.64755878 |
| 5 | Progressive macrocephaly (HP:0004481) | 3.62500971 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.62428305 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 3.39899214 |
| 8 | Increased CSF lactate (HP:0002490) | 3.35995499 |
| 9 | Abnormality of midbrain morphology (HP:0002418) | 3.09931097 |
| 10 | Molar tooth sign on MRI (HP:0002419) | 3.09931097 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.02629120 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.00048366 |
| 13 | Septo-optic dysplasia (HP:0100842) | 2.94930818 |
| 14 | Hepatic necrosis (HP:0002605) | 2.89240219 |
| 15 | Colon cancer (HP:0003003) | 2.89016813 |
| 16 | Volvulus (HP:0002580) | 2.87978310 |
| 17 | Chromsome breakage (HP:0040012) | 2.85408554 |
| 18 | Renal Fanconi syndrome (HP:0001994) | 2.83431771 |
| 19 | Pancreatic fibrosis (HP:0100732) | 2.82711839 |
| 20 | Cerebral edema (HP:0002181) | 2.82704876 |
| 21 | Methylmalonic acidemia (HP:0002912) | 2.81929402 |
| 22 | 3-Methylglutaconic aciduria (HP:0003535) | 2.80456447 |
| 23 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.76126800 |
| 24 | Supernumerary spleens (HP:0009799) | 2.72843921 |
| 25 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.67873836 |
| 26 | Meckel diverticulum (HP:0002245) | 2.66867427 |
| 27 | Medial flaring of the eyebrow (HP:0010747) | 2.63602944 |
| 28 | Abnormality of the ileum (HP:0001549) | 2.63430602 |
| 29 | Pancreatic cysts (HP:0001737) | 2.62280113 |
| 30 | Abnormality of chromosome stability (HP:0003220) | 2.55818844 |
| 31 | True hermaphroditism (HP:0010459) | 2.49485432 |
| 32 | Hyperglycinemia (HP:0002154) | 2.39792504 |
| 33 | Abnormal lung lobation (HP:0002101) | 2.38511705 |
| 34 | Reticulocytopenia (HP:0001896) | 2.38059994 |
| 35 | Median cleft lip (HP:0000161) | 2.30202924 |
| 36 | Nephronophthisis (HP:0000090) | 2.28767377 |
| 37 | Gait imbalance (HP:0002141) | 2.21854265 |
| 38 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.21312445 |
| 39 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.21312445 |
| 40 | Increased serum lactate (HP:0002151) | 2.20896499 |
| 41 | Absent septum pellucidum (HP:0001331) | 2.19986568 |
| 42 | Abnormality of the preputium (HP:0100587) | 2.19847002 |
| 43 | Congenital primary aphakia (HP:0007707) | 2.18126819 |
| 44 | Bifid tongue (HP:0010297) | 2.17657996 |
| 45 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17301295 |
| 46 | Methylmalonic aciduria (HP:0012120) | 2.16624676 |
| 47 | Macrocytic anemia (HP:0001972) | 2.14785923 |
| 48 | Lactic acidosis (HP:0003128) | 2.14542592 |
| 49 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.12328945 |
| 50 | Short tibia (HP:0005736) | 2.10524906 |
| 51 | Triphalangeal thumb (HP:0001199) | 2.10115366 |
| 52 | Optic disc pallor (HP:0000543) | 2.09096550 |
| 53 | Oligodactyly (hands) (HP:0001180) | 2.06968295 |
| 54 | Myokymia (HP:0002411) | 2.04447034 |
| 55 | Optic nerve hypoplasia (HP:0000609) | 2.04268606 |
| 56 | Small intestinal stenosis (HP:0012848) | 2.04247153 |
| 57 | Duodenal stenosis (HP:0100867) | 2.04247153 |
| 58 | Nephrogenic diabetes insipidus (HP:0009806) | 2.04226485 |
| 59 | Bile duct proliferation (HP:0001408) | 2.03357599 |
| 60 | Abnormal biliary tract physiology (HP:0012439) | 2.03357599 |
| 61 | Genital tract atresia (HP:0001827) | 2.02390086 |
| 62 | Leukodystrophy (HP:0002415) | 1.97264838 |
| 63 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.95383154 |
| 64 | Gonadotropin excess (HP:0000837) | 1.93741894 |
| 65 | Respiratory failure (HP:0002878) | 1.93590715 |
| 66 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.92482721 |
| 67 | Exertional dyspnea (HP:0002875) | 1.92134782 |
| 68 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.90826907 |
| 69 | Aplastic anemia (HP:0001915) | 1.88668575 |
| 70 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.88491237 |
| 71 | Megaloblastic anemia (HP:0001889) | 1.88019402 |
| 72 | Intestinal atresia (HP:0011100) | 1.86655745 |
| 73 | Abnormality of the duodenum (HP:0002246) | 1.86228479 |
| 74 | Vaginal atresia (HP:0000148) | 1.84883662 |
| 75 | Abnormality of the septum pellucidum (HP:0007375) | 1.84729210 |
| 76 | Facial hemangioma (HP:0000329) | 1.83019849 |
| 77 | Abnormal number of erythroid precursors (HP:0012131) | 1.82815337 |
| 78 | Abnormality of methionine metabolism (HP:0010901) | 1.82428372 |
| 79 | Sclerocornea (HP:0000647) | 1.82296193 |
| 80 | Hypoplasia of the fovea (HP:0007750) | 1.82204586 |
| 81 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.82204586 |
| 82 | Exercise intolerance (HP:0003546) | 1.81811340 |
| 83 | Oligodactyly (HP:0012165) | 1.81270580 |
| 84 | Absent thumb (HP:0009777) | 1.80330703 |
| 85 | Abnormality of the fovea (HP:0000493) | 1.79689155 |
| 86 | Abnormality of the renal medulla (HP:0100957) | 1.78964616 |
| 87 | Postaxial hand polydactyly (HP:0001162) | 1.76711058 |
| 88 | Abnormality of renal resorption (HP:0011038) | 1.74862377 |
| 89 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.74044356 |
| 90 | Abnormality of the anterior horn cell (HP:0006802) | 1.73393656 |
| 91 | Degeneration of anterior horn cells (HP:0002398) | 1.73393656 |
| 92 | Pendular nystagmus (HP:0012043) | 1.71721028 |
| 93 | Renal cortical cysts (HP:0000803) | 1.71168943 |
| 94 | Microvesicular hepatic steatosis (HP:0001414) | 1.70742834 |
| 95 | Postaxial foot polydactyly (HP:0001830) | 1.69461258 |
| 96 | Increased serum pyruvate (HP:0003542) | 1.68938212 |
| 97 | Type I transferrin isoform profile (HP:0003642) | 1.67514234 |
| 98 | Lethargy (HP:0001254) | 1.67503042 |
| 99 | Abnormality of urine glucose concentration (HP:0011016) | 1.67478900 |
| 100 | Glycosuria (HP:0003076) | 1.67478900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 3.30306192 |
| 2 | BUB1 | 2.99173657 |
| 3 | WNK3 | 2.90460890 |
| 4 | VRK2 | 2.71877269 |
| 5 | TRIM28 | 2.51490922 |
| 6 | NUAK1 | 2.39481679 |
| 7 | ZAK | 2.22422837 |
| 8 | TTK | 2.14602883 |
| 9 | MAP4K2 | 2.11690653 |
| 10 | SRPK1 | 2.08084197 |
| 11 | PBK | 2.08060780 |
| 12 | STK16 | 2.03684631 |
| 13 | TNIK | 1.96306967 |
| 14 | VRK1 | 1.96102632 |
| 15 | PLK3 | 1.91488542 |
| 16 | EIF2AK3 | 1.89976167 |
| 17 | PLK4 | 1.86980923 |
| 18 | NEK1 | 1.78427791 |
| 19 | CASK | 1.73754668 |
| 20 | MST4 | 1.73534980 |
| 21 | BMPR1B | 1.63995419 |
| 22 | DYRK2 | 1.53588029 |
| 23 | WEE1 | 1.51279090 |
| 24 | EIF2AK1 | 1.50224386 |
| 25 | PLK1 | 1.49499506 |
| 26 | MAP3K4 | 1.48709692 |
| 27 | MAPK13 | 1.43736287 |
| 28 | BCR | 1.38416001 |
| 29 | CSNK1G1 | 1.35005577 |
| 30 | MKNK1 | 1.34222329 |
| 31 | CSNK1G2 | 1.31898914 |
| 32 | CSNK1G3 | 1.29870486 |
| 33 | MAP2K7 | 1.26584656 |
| 34 | BCKDK | 1.22755085 |
| 35 | MKNK2 | 1.18330822 |
| 36 | CDK19 | 1.18248625 |
| 37 | FRK | 1.16683015 |
| 38 | BRSK2 | 1.15467713 |
| 39 | NME1 | 1.14184303 |
| 40 | TAF1 | 1.13641468 |
| 41 | TLK1 | 1.09130627 |
| 42 | PNCK | 1.09045617 |
| 43 | MARK1 | 1.07031369 |
| 44 | NEK2 | 1.02138264 |
| 45 | MAP3K9 | 1.00539343 |
| 46 | MAP3K12 | 0.97895743 |
| 47 | TSSK6 | 0.97818737 |
| 48 | ATR | 0.97528710 |
| 49 | CSNK1A1L | 0.96947147 |
| 50 | AURKA | 0.96678352 |
| 51 | TAOK3 | 0.94723754 |
| 52 | CHEK2 | 0.93374859 |
| 53 | ACVR1B | 0.92451010 |
| 54 | ERBB3 | 0.91412518 |
| 55 | CCNB1 | 0.89141356 |
| 56 | PLK2 | 0.88582977 |
| 57 | ARAF | 0.86477336 |
| 58 | AURKB | 0.84488331 |
| 59 | GRK1 | 0.84100450 |
| 60 | OXSR1 | 0.83331579 |
| 61 | STK39 | 0.81285083 |
| 62 | RPS6KA4 | 0.80535214 |
| 63 | PINK1 | 0.79760523 |
| 64 | DYRK3 | 0.79314168 |
| 65 | BRSK1 | 0.76987556 |
| 66 | ATM | 0.75100657 |
| 67 | EPHA4 | 0.70960283 |
| 68 | ADRBK2 | 0.69889251 |
| 69 | STK3 | 0.67864177 |
| 70 | NTRK2 | 0.66040940 |
| 71 | INSRR | 0.65947043 |
| 72 | EIF2AK2 | 0.62921606 |
| 73 | MINK1 | 0.61128250 |
| 74 | PRKCG | 0.59925941 |
| 75 | CSNK2A2 | 0.59657361 |
| 76 | CHEK1 | 0.58329378 |
| 77 | CSNK2A1 | 0.57114430 |
| 78 | CSNK1E | 0.53678410 |
| 79 | PKN1 | 0.50503519 |
| 80 | CDK3 | 0.50233780 |
| 81 | STK38L | 0.50053725 |
| 82 | TIE1 | 0.49454886 |
| 83 | CDK8 | 0.49028666 |
| 84 | PASK | 0.47551036 |
| 85 | BRAF | 0.46695516 |
| 86 | CAMK2A | 0.45024371 |
| 87 | PRKCE | 0.45007820 |
| 88 | LIMK1 | 0.44438142 |
| 89 | NEK6 | 0.42835076 |
| 90 | CDK9 | 0.41375289 |
| 91 | UHMK1 | 0.41097377 |
| 92 | CDK2 | 0.40089730 |
| 93 | STK24 | 0.39671712 |
| 94 | PDK2 | 0.39661881 |
| 95 | CDK14 | 0.39596294 |
| 96 | CSNK1D | 0.39388599 |
| 97 | CSNK1A1 | 0.39375533 |
| 98 | WNK4 | 0.39348922 |
| 99 | CDK1 | 0.39228514 |
| 100 | CDK7 | 0.39190454 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.51592493 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.51514633 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 3.33444647 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.24782110 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.08033269 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.97200938 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.89760223 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.89224139 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.71420791 |
| 10 | Basal transcription factors_Homo sapiens_hsa03022 | 2.50593452 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.47607607 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.30080843 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.28186998 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.20235779 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.19025535 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 2.11979647 |
| 17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.05842880 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.05709766 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.94372257 |
| 20 | Spliceosome_Homo sapiens_hsa03040 | 1.94248512 |
| 21 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.75794991 |
| 22 | RNA transport_Homo sapiens_hsa03013 | 1.71137525 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.71062966 |
| 24 | Cell cycle_Homo sapiens_hsa04110 | 1.70075984 |
| 25 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.48554298 |
| 26 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.47331590 |
| 27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.47277893 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.45721177 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.44088583 |
| 30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.43487046 |
| 31 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.32497488 |
| 32 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.24784661 |
| 33 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.23571250 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.23324528 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.23219525 |
| 36 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.19246871 |
| 37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.18499521 |
| 38 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.16500005 |
| 39 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.15301169 |
| 40 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.14394865 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 1.11110198 |
| 42 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.08356303 |
| 43 | Nicotine addiction_Homo sapiens_hsa05033 | 1.04348683 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.97602543 |
| 45 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.84128786 |
| 46 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.79871204 |
| 47 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.79041076 |
| 48 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.73084133 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72179966 |
| 50 | Olfactory transduction_Homo sapiens_hsa04740 | 0.70701574 |
| 51 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.69496962 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.69312148 |
| 53 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.63997626 |
| 54 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59174530 |
| 55 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.58689260 |
| 56 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.58377311 |
| 57 | Taste transduction_Homo sapiens_hsa04742 | 0.57479492 |
| 58 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.56296916 |
| 59 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.53136410 |
| 60 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.52613086 |
| 61 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.51718401 |
| 62 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.51654520 |
| 63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.50338028 |
| 64 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.50254747 |
| 65 | GABAergic synapse_Homo sapiens_hsa04727 | 0.47227318 |
| 66 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.45285816 |
| 67 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.43337123 |
| 68 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.41858925 |
| 69 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.41468478 |
| 70 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.40585444 |
| 71 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.39847027 |
| 72 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.38978490 |
| 73 | Carbon metabolism_Homo sapiens_hsa01200 | 0.38961057 |
| 74 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.38329866 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37592862 |
| 76 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.36757030 |
| 77 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.36169280 |
| 78 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.35647786 |
| 79 | Morphine addiction_Homo sapiens_hsa05032 | 0.35147708 |
| 80 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.35095265 |
| 81 | Retinol metabolism_Homo sapiens_hsa00830 | 0.31802434 |
| 82 | Sulfur relay system_Homo sapiens_hsa04122 | 0.30140329 |
| 83 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29700266 |
| 84 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.29479334 |
| 85 | Circadian rhythm_Homo sapiens_hsa04710 | 0.29054035 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.28589914 |
| 87 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.28186752 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27812568 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.27225721 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.26998059 |
| 91 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.26778010 |
| 92 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.25717015 |
| 93 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.24967608 |
| 94 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24285787 |
| 95 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23800743 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.23054172 |
| 97 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21644936 |
| 98 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.20586452 |
| 99 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.20049050 |
| 100 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.18829532 |

