HPGD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)5.75736352
2L-phenylalanine catabolic process (GO:0006559)5.65002834
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.65002834
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.54740381
5high-density lipoprotein particle remodeling (GO:0034375)5.41957022
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.38026502
7L-phenylalanine metabolic process (GO:0006558)5.38026502
8protein carboxylation (GO:0018214)5.15359813
9peptidyl-glutamic acid carboxylation (GO:0017187)5.15359813
10sulfur amino acid catabolic process (GO:0000098)5.12918035
11aromatic amino acid family catabolic process (GO:0009074)5.06180656
12complement activation, alternative pathway (GO:0006957)5.02484628
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.97325077
14reverse cholesterol transport (GO:0043691)4.88026988
15alpha-linolenic acid metabolic process (GO:0036109)4.87387903
16intestinal absorption (GO:0050892)4.80312944
17negative regulation of fibrinolysis (GO:0051918)4.72465244
18regulation of protein activation cascade (GO:2000257)4.68864935
19urea metabolic process (GO:0019627)4.64306324
20urea cycle (GO:0000050)4.64306324
21tryptophan catabolic process (GO:0006569)4.56715397
22indole-containing compound catabolic process (GO:0042436)4.56715397
23indolalkylamine catabolic process (GO:0046218)4.56715397
24phospholipid efflux (GO:0033700)4.54767830
25bile acid biosynthetic process (GO:0006699)4.53096281
26regulation of complement activation (GO:0030449)4.51172361
27kynurenine metabolic process (GO:0070189)4.45731581
28plasma lipoprotein particle remodeling (GO:0034369)4.41412087
29protein-lipid complex remodeling (GO:0034368)4.41412087
30macromolecular complex remodeling (GO:0034367)4.41412087
31cysteine metabolic process (GO:0006534)4.40125765
32regulation of cholesterol esterification (GO:0010872)4.39877697
33regulation of fibrinolysis (GO:0051917)4.38296501
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36000703
35glyoxylate metabolic process (GO:0046487)4.34653970
36lipoprotein transport (GO:0042953)4.32570124
37regulation of triglyceride catabolic process (GO:0010896)4.31255667
38glucocorticoid biosynthetic process (GO:0006704)4.29682458
39tryptophan metabolic process (GO:0006568)4.29344816
40phospholipid homeostasis (GO:0055091)4.29025236
41fat-soluble vitamin biosynthetic process (GO:0042362)4.25204575
42homocysteine metabolic process (GO:0050667)4.22025341
43nitrogen cycle metabolic process (GO:0071941)4.21570935
44bile acid and bile salt transport (GO:0015721)4.14428742
45negative regulation of cholesterol transport (GO:0032375)4.12860169
46negative regulation of sterol transport (GO:0032372)4.12860169
47NADH metabolic process (GO:0006734)4.09359145
48bile acid metabolic process (GO:0008206)4.07733497
49drug catabolic process (GO:0042737)4.07455319
50cellular glucuronidation (GO:0052695)4.03125313
51cholesterol efflux (GO:0033344)3.98428291
52progesterone metabolic process (GO:0042448)3.97837952
53plasma lipoprotein particle clearance (GO:0034381)3.94526291
54flavonoid metabolic process (GO:0009812)3.85482217
55drug metabolic process (GO:0017144)3.85206255
56plasma lipoprotein particle assembly (GO:0034377)3.81505739
57ethanol oxidation (GO:0006069)3.79420105
58response to nitrosative stress (GO:0051409)3.78852114
59amino-acid betaine metabolic process (GO:0006577)3.72570654
60regulation of guanylate cyclase activity (GO:0031282)3.70803627
61epoxygenase P450 pathway (GO:0019373)3.69809396
62acylglycerol homeostasis (GO:0055090)3.66266518
63triglyceride homeostasis (GO:0070328)3.66266518
64renal system process involved in regulation of blood volume (GO:0001977)3.64154908
65exogenous drug catabolic process (GO:0042738)3.63655370
66benzene-containing compound metabolic process (GO:0042537)3.63427041
67uronic acid metabolic process (GO:0006063)3.59875032
68glucuronate metabolic process (GO:0019585)3.59875032
69cholesterol homeostasis (GO:0042632)3.59173407
70surfactant homeostasis (GO:0043129)3.57895711
71desmosome organization (GO:0002934)3.57817488
72serine family amino acid catabolic process (GO:0009071)3.57732695
73lysine catabolic process (GO:0006554)3.57595109
74lysine metabolic process (GO:0006553)3.57595109
75xenobiotic catabolic process (GO:0042178)3.56000914
76plasma lipoprotein particle organization (GO:0071827)3.54984680
77aromatic amino acid family metabolic process (GO:0009072)3.54330090
78sterol homeostasis (GO:0055092)3.52750575
79protein-lipid complex assembly (GO:0065005)3.51587295
80tyrosine metabolic process (GO:0006570)3.51299124
81positive regulation of lipoprotein lipase activity (GO:0051006)3.48499138
82positive regulation of triglyceride lipase activity (GO:0061365)3.48499138
83negative regulation of lipase activity (GO:0060192)3.48405734
84low-density lipoprotein particle remodeling (GO:0034374)3.46736256
85cellular ketone body metabolic process (GO:0046950)3.45370032
86complement activation (GO:0006956)3.45074959
87complement activation, classical pathway (GO:0006958)3.44934229
88peptide catabolic process (GO:0043171)3.43991052
89regulation of cholesterol homeostasis (GO:2000188)3.42134786
90protein-lipid complex subunit organization (GO:0071825)3.39323717
91response to phenylpropanoid (GO:0080184)3.38342791
92positive regulation of lipid catabolic process (GO:0050996)3.37653503
93protein activation cascade (GO:0072376)3.35742015
94fibrinolysis (GO:0042730)3.35058862
95hormone catabolic process (GO:0042447)3.34664381
96citrulline biosynthetic process (GO:0019240)3.34486340
97alpha-amino acid catabolic process (GO:1901606)3.34277400
98regulation of bile acid biosynthetic process (GO:0070857)3.27386047
99androgen biosynthetic process (GO:0006702)3.26552166
100cellular modified amino acid catabolic process (GO:0042219)3.25279456
101lipoprotein metabolic process (GO:0042157)3.21906448
102glucocorticoid metabolic process (GO:0008211)3.20397329
103intestinal cholesterol absorption (GO:0030299)3.19133092
104bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18440893
105cellular amino acid catabolic process (GO:0009063)3.18148024
106renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.17884832
107regulation of cholesterol biosynthetic process (GO:0045540)3.16012282
108positive regulation of fatty acid beta-oxidation (GO:0032000)3.14422195
109regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.14288382
110endocrine process (GO:0050886)3.14288382
111regulation of systemic arterial blood pressure by hormone (GO:0001990)3.14288382
112amine catabolic process (GO:0009310)3.10865203
113cellular biogenic amine catabolic process (GO:0042402)3.10865203
114ethanol metabolic process (GO:0006067)3.09033374
115indolalkylamine metabolic process (GO:0006586)3.09000095
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08501408
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08501408
118very-low-density lipoprotein particle assembly (GO:0034379)3.08187074
119opsonization (GO:0008228)3.07306762
120regulation of cellular extravasation (GO:0002691)3.06740493
121drug transmembrane transport (GO:0006855)3.06681200
122cholesterol transport (GO:0030301)3.06182830
123sterol transport (GO:0015918)3.06182830
124cGMP-mediated signaling (GO:0019934)3.05893995
125regulation of cholesterol metabolic process (GO:0090181)3.05877902
126omega-hydroxylase P450 pathway (GO:0097267)3.03221810
127vitamin transmembrane transport (GO:0035461)2.97301239
128xenobiotic metabolic process (GO:0006805)2.95114929
129C21-steroid hormone metabolic process (GO:0008207)2.94466188
130diacylglycerol metabolic process (GO:0046339)2.92315424
131primary alcohol catabolic process (GO:0034310)2.90940915
132drug transport (GO:0015893)2.88110095
133androgen metabolic process (GO:0008209)2.86553402
134vitamin D metabolic process (GO:0042359)2.85859921
135glycosphingolipid catabolic process (GO:0046479)2.81182350
136fructose metabolic process (GO:0006000)2.80841114
137phenylpropanoid metabolic process (GO:0009698)2.80303180
138multicellular organismal water homeostasis (GO:0050891)2.79950039
139primary alcohol metabolic process (GO:0034308)2.78307439
140endothelium development (GO:0003158)2.74237262
141alkaloid metabolic process (GO:0009820)2.73427711
142C21-steroid hormone biosynthetic process (GO:0006700)2.71153795
143glycolipid catabolic process (GO:0019377)2.70732813
144glycoside metabolic process (GO:0016137)2.69832793
145positive regulation of pseudopodium assembly (GO:0031274)2.68323914
146* cyclooxygenase pathway (GO:0019371)2.68257823
147negative regulation of blood coagulation (GO:0030195)2.67418891
148negative regulation of hemostasis (GO:1900047)2.67418891
149embryonic process involved in female pregnancy (GO:0060136)2.66570723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.00201658
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.44984384
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.70613915
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.30772229
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.99656320
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76601336
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.95488990
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.75381682
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.30829382
10GATA1_22025678_ChIP-Seq_K562_Human2.95298586
11CLOCK_20551151_ChIP-Seq_293T_Human2.81195751
12* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72582533
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44167822
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.06609297
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.87155133
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86884666
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76340702
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72777778
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.68836669
20* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67508024
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65138514
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64074959
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63273990
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61189495
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60640921
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60091502
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54428264
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.52780778
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.50673944
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48421192
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.48394827
32* IRF8_27001747_Chip-Seq_BMDM_Mouse1.46702979
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.46276480
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46226645
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.45006200
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.44301806
37SCL_19346495_ChIP-Seq_HPC-7_Human1.41966215
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40491031
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39085388
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38670054
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37620454
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32170703
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31792826
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25034995
45* GATA4_25053715_ChIP-Seq_YYC3_Human1.24706671
46ZNF263_19887448_ChIP-Seq_K562_Human1.23030499
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22309672
48AR_21909140_ChIP-Seq_LNCAP_Human1.19553580
49* FOXA1_25552417_ChIP-Seq_VCAP_Human1.19463925
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17589551
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17126578
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.16358312
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15109084
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.14894589
55* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14476453
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.12814644
57* SOX2_20726797_ChIP-Seq_SW620_Human1.12480393
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12043369
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11707670
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09950767
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09950767
62* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07076480
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05307616
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.04526551
65KLF5_25053715_ChIP-Seq_YYC3_Human1.03516043
66CDX2_22108803_ChIP-Seq_LS180_Human0.98209915
67* TP63_23658742_ChIP-Seq_EP156T_Human0.97982082
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97645489
69STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95304776
70LXR_22292898_ChIP-Seq_THP-1_Human0.93856797
71PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93125798
72GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91932038
73* GATA6_25053715_ChIP-Seq_YYC3_Human0.90732397
74ESR1_20079471_ChIP-ChIP_T-47D_Human0.89004611
75GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88007913
76GATA1_19941826_ChIP-Seq_K562_Human0.87664178
77* GATA2_19941826_ChIP-Seq_K562_Human0.87403009
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86801589
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86801589
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86583005
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85495163
82* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83808434
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83036932
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82996600
85FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81759905
86RACK7_27058665_Chip-Seq_MCF-7_Human0.80927451
87* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80502341
88RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79037354
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78248936
90* CEBPB_22108803_ChIP-Seq_LS180_Human0.77439704
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77074604
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75795410
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74491245
94P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74363812
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.74293538
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71084075
97* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71064379
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71047816
99EGR1_19032775_ChIP-ChIP_M12_Human0.69959872
100RUNX_20019798_ChIP-Seq_JUKART_Human0.69948208
101HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69710914
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67812777
103TBX20_22328084_ChIP-Seq_HEART_Mouse0.67328073
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.67328073
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.67244777
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66848899
107CJUN_26792858_Chip-Seq_BT549_Human0.66750117
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65670384
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65035439
110VDR_21846776_ChIP-Seq_THP-1_Human0.64822568
111* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64758363
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.64441732
113AHR_22903824_ChIP-Seq_MCF-7_Human0.63298341
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.62897447
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.62194187
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.61609682
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.61468717
118BCAT_22108803_ChIP-Seq_LS180_Human0.61288105
119VDR_24787735_ChIP-Seq_THP-1_Human0.61205983
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60632080
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.60262072
122VDR_24763502_ChIP-Seq_THP-1_Human0.59889250
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.59660093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.41087019
2MP0002139_abnormal_hepatobiliary_system6.37565318
3MP0005085_abnormal_gallbladder_physiolo5.22352448
4MP0008875_abnormal_xenobiotic_pharmacok4.80901527
5MP0005365_abnormal_bile_salt4.78561146
6MP0009840_abnormal_foam_cell3.65261319
7MP0003191_abnormal_cellular_cholesterol3.39936747
8MP0010329_abnormal_lipoprotein_level3.32050047
9MP0003252_abnormal_bile_duct3.28931224
10MP0003806_abnormal_nucleotide_metabolis2.63776001
11MP0001666_abnormal_nutrient_absorption2.44886462
12MP0002138_abnormal_hepatobiliary_system2.28599167
13MP0005083_abnormal_biliary_tract2.27975942
14MP0009379_abnormal_foot_pigmentation2.20385322
15MP0010352_gastrointestinal_tract_polyps2.10385306
16MP0003183_abnormal_peptide_metabolism2.09909828
17MP0005332_abnormal_amino_acid2.08631633
18MP0002254_reproductive_system_inflammat1.94089980
19MP0000609_abnormal_liver_physiology1.89025973
20MP0004019_abnormal_vitamin_homeostasis1.86750861
21* MP0002118_abnormal_lipid_homeostasis1.82667832
22MP0010368_abnormal_lymphatic_system1.76326563
23MP0004147_increased_porphyrin_level1.75812158
24MP0003705_abnormal_hypodermis_morpholog1.72018933
25MP0005319_abnormal_enzyme/_coenzyme1.66673576
26MP0004782_abnormal_surfactant_physiolog1.66118918
27MP0005409_darkened_coat_color1.59334302
28MP0003724_increased_susceptibility_to1.57593608
29MP0003866_abnormal_defecation1.53108802
30MP0005501_abnormal_skin_physiology1.46662025
31MP0001664_abnormal_digestion1.41966592
32MP0005058_abnormal_lysosome_morphology1.40834953
33MP0000516_abnormal_urinary_system1.40215849
34MP0005367_renal/urinary_system_phenotyp1.40215849
35MP0009764_decreased_sensitivity_to1.39874475
36MP0003195_calcinosis1.37300748
37MP0001764_abnormal_homeostasis1.37107055
38MP0001765_abnormal_ion_homeostasis1.32244739
39MP0009643_abnormal_urine_homeostasis1.31996057
40MP0005464_abnormal_platelet_physiology1.29149597
41MP0003300_gastrointestinal_ulcer1.28908610
42MP0005584_abnormal_enzyme/coenzyme_acti1.20907992
43MP0010678_abnormal_skin_adnexa1.19990088
44MP0002876_abnormal_thyroid_physiology1.19630678
45MP0003868_abnormal_feces_composition1.17643725
46MP0000477_abnormal_intestine_morphology1.14923725
47MP0005167_abnormal_blood-brain_barrier1.12288186
48MP0008469_abnormal_protein_level1.12146344
49MP0003075_altered_response_to1.12110920
50MP0003690_abnormal_glial_cell1.11187619
51MP0000604_amyloidosis1.09194254
52MP0002098_abnormal_vibrissa_morphology1.08448084
53MP0010234_abnormal_vibrissa_follicle1.05452387
54MP0003303_peritoneal_inflammation1.03099853
55MP0000598_abnormal_liver_morphology1.03014882
56MP0003186_abnormal_redox_activity1.00399257
57MP0006082_CNS_inflammation0.99261202
58MP0001835_abnormal_antigen_presentation0.98600712
59MP0004883_abnormal_blood_vessel0.98222453
60MP0003436_decreased_susceptibility_to0.97922493
61MP0000490_abnormal_crypts_of0.96418631
62MP0002132_abnormal_respiratory_system0.96249315
63MP0000537_abnormal_urethra_morphology0.95772074
64MP0001542_abnormal_bone_strength0.94778165
65MP0009763_increased_sensitivity_to0.93962674
66MP0004264_abnormal_extraembryonic_tissu0.93811740
67MP0004130_abnormal_muscle_cell0.92222243
68MP0001533_abnormal_skeleton_physiology0.92099445
69MP0005164_abnormal_response_to0.91557678
70MP0003329_amyloid_beta_deposits0.91167674
71MP0005670_abnormal_white_adipose0.89610858
72MP0005166_decreased_susceptibility_to0.89563116
73MP0000249_abnormal_blood_vessel0.88087795
74MP0000465_gastrointestinal_hemorrhage0.87450368
75MP0001851_eye_inflammation0.87047077
76MP0005023_abnormal_wound_healing0.87011138
77MP0001216_abnormal_epidermal_layer0.86623901
78MP0010386_abnormal_urinary_bladder0.85920916
79MP0003656_abnormal_erythrocyte_physiolo0.85888754
80MP0005451_abnormal_body_composition0.82952663
81MP0005165_increased_susceptibility_to0.82756550
82MP0009333_abnormal_splenocyte_physiolog0.82360101
83MP0003941_abnormal_skin_development0.81058078
84MP0001756_abnormal_urination0.80808287
85MP0009384_cardiac_valve_regurgitation0.79930960
86MP0005647_abnormal_sex_gland0.79583498
87MP0005376_homeostasis/metabolism_phenot0.79457556
88MP0000343_altered_response_to0.78081022
89MP0002419_abnormal_innate_immunity0.77950241
90* MP0009642_abnormal_blood_homeostasis0.77826331
91MP0009697_abnormal_copulation0.77541212
92MP0008438_abnormal_cutaneous_collagen0.77501455
93MP0001879_abnormal_lymphatic_vessel0.76518538
94MP0010155_abnormal_intestine_physiology0.76332748
95MP0005666_abnormal_adipose_tissue0.75560531
96MP0003566_abnormal_cell_adhesion0.74379182
97MP0008004_abnormal_stomach_pH0.73215556
98MP0004272_abnormal_basement_membrane0.72190028
99MP0001845_abnormal_inflammatory_respons0.72154358
100MP0005334_abnormal_fat_pad0.71571470
101MP0001873_stomach_inflammation0.71128837
102MP0005448_abnormal_energy_balance0.70895552
103MP0004185_abnormal_adipocyte_glucose0.70129270
104MP0005636_abnormal_mineral_homeostasis0.69287466
105MP0002971_abnormal_brown_adipose0.68930459
106MP0009053_abnormal_anal_canal0.68855586
107MP0003828_pulmonary_edema0.68385816
108MP0002136_abnormal_kidney_physiology0.68127530
109MP0005275_abnormal_skin_tensile0.67676085
110MP0003638_abnormal_response/metabolism_0.67608117
111MP0000230_abnormal_systemic_arterial0.66934946
112MP0005408_hypopigmentation0.66434712
113MP0004043_abnormal_pH_regulation0.65219553
114MP0002009_preneoplasia0.64981993
115MP0002998_abnormal_bone_remodeling0.64918817
116MP0005381_digestive/alimentary_phenotyp0.64652827
117MP0000377_abnormal_hair_follicle0.64520240
118MP0001853_heart_inflammation0.63643270
119MP0009115_abnormal_fat_cell0.62403588
120MP0009765_abnormal_xenobiotic_induced0.62337122
121MP0005025_abnormal_response_to0.62051777
122MP0001958_emphysema0.60240511
123MP0005535_abnormal_body_temperature0.60162762
124MP0000383_abnormal_hair_follicle0.59840581
125MP0008873_increased_physiological_sensi0.59703160
126MP0001986_abnormal_taste_sensitivity0.59424948
127MP0001661_extended_life_span0.59296014
128MP0002166_altered_tumor_susceptibility0.58271123
129MP0002060_abnormal_skin_morphology0.56980733
130MP0003453_abnormal_keratinocyte_physiol0.56666953
131MP0000685_abnormal_immune_system0.55328885
132MP0002295_abnormal_pulmonary_circulatio0.54924317
133MP0009785_altered_susceptibility_to0.54714420
134MP0001663_abnormal_digestive_system0.54576110
135MP0002796_impaired_skin_barrier0.54251883
136MP0003011_delayed_dark_adaptation0.52387970
137MP0004947_skin_inflammation0.51851431
138MP0000767_abnormal_smooth_muscle0.51654928
139MP0000538_abnormal_urinary_bladder0.51585479

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.71096950
2Complement deficiency (HP:0004431)5.97264024
3Intrahepatic cholestasis (HP:0001406)5.72845284
4Xanthomatosis (HP:0000991)5.41051332
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.33552864
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.24938108
7Hypobetalipoproteinemia (HP:0003563)5.03873870
8Prolonged partial thromboplastin time (HP:0003645)4.97142012
9Joint hemorrhage (HP:0005261)4.86466548
10Systemic lupus erythematosus (HP:0002725)4.80652409
11Abnormality of complement system (HP:0005339)4.55412314
12Hyperlipoproteinemia (HP:0010980)4.54243921
13Hyperactive renin-angiotensin system (HP:0000841)4.00239423
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99901833
15Abnormality of the common coagulation pathway (HP:0010990)3.86181201
16Hypolipoproteinemia (HP:0010981)3.85992401
17Decreased circulating renin level (HP:0003351)3.70603724
18Epidermoid cyst (HP:0200040)3.70522345
19Glomerulonephritis (HP:0000099)3.69161328
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66909994
21Fat malabsorption (HP:0002630)3.60269535
22Hyperammonemia (HP:0001987)3.48575695
23Hypoalphalipoproteinemia (HP:0003233)3.40797553
24Abnormality of the intrinsic pathway (HP:0010989)3.37985606
25Hypercholesterolemia (HP:0003124)3.34437456
26Recurrent gram-negative bacterial infections (HP:0005420)3.32712830
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.21782087
28Myocardial infarction (HP:0001658)3.21377222
29Hyperglycinuria (HP:0003108)3.18100392
30Alkalosis (HP:0001948)3.15205264
31Conjugated hyperbilirubinemia (HP:0002908)3.12015957
32Chronic diarrhea (HP:0002028)3.11733913
33Polycythemia (HP:0001901)3.07155334
34Ketosis (HP:0001946)3.05487391
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.00288649
36Esophageal varix (HP:0002040)2.97254043
37Widely patent fontanelles and sutures (HP:0004492)2.96453579
38Abnormality of glycine metabolism (HP:0010895)2.95876932
39Abnormality of serine family amino acid metabolism (HP:0010894)2.95876932
40Vascular calcification (HP:0004934)2.94815581
41Hyperaldosteronism (HP:0000859)2.89931665
42Abnormality of renin-angiotensin system (HP:0000847)2.87192678
43Amyloidosis (HP:0011034)2.85409002
44Abnormality of methionine metabolism (HP:0010901)2.84179290
45Spontaneous hematomas (HP:0007420)2.83856282
46Hyperglycinemia (HP:0002154)2.83808006
47Abnormality of vitamin metabolism (HP:0100508)2.80329800
48Hypoglycemic coma (HP:0001325)2.79333588
49Nephritis (HP:0000123)2.74141798
50Flat acetabular roof (HP:0003180)2.72251225
51Renal salt wasting (HP:0000127)2.70308358
52Cardiovascular calcification (HP:0011915)2.69213795
53Focal segmental glomerulosclerosis (HP:0000097)2.67105858
54Abnormality of fatty-acid metabolism (HP:0004359)2.67035538
55Steatorrhea (HP:0002570)2.64818146
56Metabolic alkalosis (HP:0200114)2.64146458
57Ileus (HP:0002595)2.61074509
58Abnormality of the vitamin B12 metabolism (HP:0004341)2.60206315
59Proximal tubulopathy (HP:0000114)2.59750692
60Abnormality of pyrimidine metabolism (HP:0004353)2.59404048
61Hyperbilirubinemia (HP:0002904)2.56708644
62Abnormality of proline metabolism (HP:0010907)2.53933066
63Hydroxyprolinuria (HP:0003080)2.53933066
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50491989
65Hematochezia (HP:0002573)2.49827347
66Hepatocellular carcinoma (HP:0001402)2.49598240
67Abdominal distention (HP:0003270)2.49018929
68Abnormality of nucleobase metabolism (HP:0010932)2.47963883
69Right ventricular cardiomyopathy (HP:0011663)2.46043423
70Menorrhagia (HP:0000132)2.45762837
71Pigmentary retinal degeneration (HP:0001146)2.44595770
72Abnormality of purine metabolism (HP:0004352)2.42243801
73Nausea (HP:0002018)2.39373018
74Malnutrition (HP:0004395)2.38012872
75Abnormality of vitamin B metabolism (HP:0004340)2.37843238
76Thin bony cortex (HP:0002753)2.33571902
77Glomerulosclerosis (HP:0000096)2.32457530
78Spontaneous abortion (HP:0005268)2.32365864
79Thrombophlebitis (HP:0004418)2.31966759
80Pulmonary embolism (HP:0002204)2.31804639
81Facial shape deformation (HP:0011334)2.29766967
82Potter facies (HP:0002009)2.29766967
83Abnormality of urine glucose concentration (HP:0011016)2.28749113
84Glycosuria (HP:0003076)2.28749113
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26219880
86Skin nodule (HP:0200036)2.26100084
87Conjunctival telangiectasia (HP:0000524)2.21732154
88Pancreatitis (HP:0001733)2.20084829
89Mitral stenosis (HP:0001718)2.20078787
90Wide cranial sutures (HP:0010537)2.18528702
91Confusion (HP:0001289)2.14982796
92Interstitial pulmonary disease (HP:0006530)2.14802401
93Metabolic acidosis (HP:0001942)2.13244171
94Gingival bleeding (HP:0000225)2.12312583
95Petechiae (HP:0000967)2.11592200
96Hemorrhage of the eye (HP:0011885)2.11294043
97Abnormality of small intestinal villus morphology (HP:0011472)2.09890471
98Villous atrophy (HP:0011473)2.09890471
99Abnormal tarsal ossification (HP:0008369)2.08685916
100Urinary glycosaminoglycan excretion (HP:0003541)2.08353241
101Mucopolysacchariduria (HP:0008155)2.08353241
102Ketoacidosis (HP:0001993)2.06597238
103Abnormality of the nasal mucosa (HP:0000433)2.06039214
104Hypochromic microcytic anemia (HP:0004840)2.04207393
105Aortic aneurysm (HP:0004942)2.02971146
106Purpura (HP:0000979)2.00465058
107Nephrolithiasis (HP:0000787)1.99739278
108Spastic diplegia (HP:0001264)1.99566478
109Abnormal cartilage morphology (HP:0002763)1.99308723
110Poikilocytosis (HP:0004447)1.99197952
111Rickets (HP:0002748)1.98297605
112Acanthocytosis (HP:0001927)1.96626618
113Hypotension (HP:0002615)1.95205009
114Delayed CNS myelination (HP:0002188)1.94881960
115Dysostosis multiplex (HP:0000943)1.94219649
116Abnormal glucose tolerance (HP:0001952)1.93502099
117Abnormal platelet function (HP:0011869)1.92301421
118Impaired platelet aggregation (HP:0003540)1.92301421
119Epistaxis (HP:0000421)1.92129701
120Hypophosphatemia (HP:0002148)1.91422131
121Vacuolated lymphocytes (HP:0001922)1.91355590
122Increased mean platelet volume (HP:0011877)1.91176116
123Pustule (HP:0200039)1.88730369
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88078781
125Abnormality of polysaccharide metabolism (HP:0011012)1.88078781
126Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88078781
127Dehydration (HP:0001944)1.87445280
128Abnormal gallbladder physiology (HP:0012438)1.86722669
129Cholecystitis (HP:0001082)1.86722669
130Hypokalemia (HP:0002900)1.86556418
131Axonal loss (HP:0003447)1.86442102
132Abnormality of chloride homeostasis (HP:0011422)1.84849566
133Congenital sensorineural hearing impairment (HP:0008527)1.84100795
134Abnormal enzyme/coenzyme activity (HP:0012379)1.83409505
135Renal tubular acidosis (HP:0001947)1.82816717
136Dicarboxylic aciduria (HP:0003215)1.82798137
137Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82798137
138Stroke (HP:0001297)1.82545801
139Sensorimotor neuropathy (HP:0007141)1.82434530
140Visceral angiomatosis (HP:0100761)1.81967310
141Abnormality of serum amino acid levels (HP:0003112)1.81509624
142Abnormal gallbladder morphology (HP:0012437)1.81150203
143Abnormal platelet volume (HP:0011876)1.81089880
144Enlarged epiphyses (HP:0010580)1.80642153
145Hyperuricemia (HP:0002149)1.79614830
146Increased purine levels (HP:0004368)1.79614830
147Bilateral sensorineural hearing impairment (HP:0008619)1.78579748
148Prolonged bleeding time (HP:0003010)1.77901359
149Pili torti (HP:0003777)1.77820540
150Curly hair (HP:0002212)1.74789301
151Abnormal hair laboratory examination (HP:0003328)1.70805716
152Congenital ichthyosiform erythroderma (HP:0007431)1.70474831
153* Joint swelling (HP:0001386)1.69078306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.69921971
2TGFBR24.24412222
3ERN13.65164485
4PKN23.57932771
5EPHA23.37578076
6BCKDK3.05252059
7TAOK32.97828702
8TRIB32.73733210
9AKT32.73383765
10TIE12.66115545
11FGFR42.65482586
12FRK2.56935627
13TYK22.54111155
14SIK12.39291868
15EPHB12.38232323
16PTK62.21739634
17MYLK2.11587051
18STK391.98098697
19MST41.94075185
20MST1R1.84730334
21RIPK11.75521132
22MAP3K121.71869055
23RIPK41.69065328
24PIK3CG1.65801062
25MAP3K31.49600930
26MAPK151.47628686
27BMPR21.43627938
28MAP2K31.39368914
29STK101.33946256
30PDK21.29434697
31MAP2K21.27751291
32JAK11.26988247
33FLT31.26348935
34CSK1.26149248
35NEK91.24010158
36GRK61.23872731
37JAK21.20976859
38TBK11.20544249
39INSRR1.19214240
40PRPF4B1.17897056
41FGFR21.17082473
42MAP3K21.16692857
43BLK1.16681384
44CAMK1D1.16614422
45NLK1.15407785
46MAP3K71.15067241
47STK241.14989357
48PAK41.13851754
49OXSR11.10860585
50CDK61.07823117
51LRRK21.07287639
52CSF1R1.05948726
53MAPK111.03627425
54TTN0.98318108
55EEF2K0.98106012
56EPHA30.95141729
57GRK70.92945969
58TEC0.92581730
59MAP3K10.92271428
60MAPK40.89820076
61LMTK20.89314299
62PRKAA20.85387867
63DDR20.83753286
64GRK10.83590409
65BTK0.83078818
66ERBB40.79618488
67ITK0.78385338
68ERBB30.78296914
69ZAP700.78171425
70GSK3A0.77996370
71TGFBR10.76978170
72KDR0.76060448
73FGFR30.73159606
74TESK20.72545895
75LATS10.72138485
76MAP2K60.68892091
77DAPK20.68785899
78PDPK10.67585727
79MAP3K140.67057041
80IRAK30.66885858
81IRAK40.66794560
82KIT0.65349348
83PTK20.65165343
84IKBKE0.64915405
85PAK20.63672296
86EPHB20.63254510
87SCYL20.63195134
88MAP3K100.62843189
89RPS6KA20.61721405
90PDGFRB0.60753500
91PRKG20.59333807
92TESK10.57436829
93MAPKAPK30.54788456
94RET0.54630193
95PRKACG0.52302956
96BMX0.52254369
97PDK10.51435843
98MAP2K10.51362603
99PIK3CA0.49765546
100MAPK120.49365887
101YES10.49348673
102RPS6KL10.49187503
103RPS6KC10.49187503
104CAMK1G0.48328762
105MAP2K40.45330405
106MAP4K10.45290549
107RPS6KB20.44800470
108RPS6KA60.44142276
109MET0.43873546
110DYRK1B0.43695413
111IGF1R0.43693831
112KSR20.43298391
113ABL20.42069274
114MAP3K60.42050035
115MATK0.41733126
116MAP3K110.41544205
117SIK20.41177593
118MAPK70.41054403
119PDGFRA0.40341081
120ERBB20.40313958
121TRPM70.40000672
122PRKD10.39935043
123FER0.38991312
124DMPK0.38823888
125SGK30.38509129
126EGFR0.38265071
127STK30.38092785
128PIM10.37903985
129MELK0.37820190
130CDC42BPA0.35242399
131SRC0.35114428
132ILK0.33524497
133JAK30.32323421
134BCR0.31019356
135PRKCA0.28129854
136PRKCD0.27466080

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.78440746
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.56189884
3Nitrogen metabolism_Homo sapiens_hsa009103.14107853
4Complement and coagulation cascades_Homo sapiens_hsa046102.82860984
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.64021504
6Tryptophan metabolism_Homo sapiens_hsa003802.62471627
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.61232133
8Caffeine metabolism_Homo sapiens_hsa002322.50592277
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47821204
10Arginine biosynthesis_Homo sapiens_hsa002202.47112254
11Staphylococcus aureus infection_Homo sapiens_hsa051502.37628343
12Fatty acid degradation_Homo sapiens_hsa000712.33984563
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30339830
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28631656
15Chemical carcinogenesis_Homo sapiens_hsa052042.20889158
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09998070
17Histidine metabolism_Homo sapiens_hsa003402.04424457
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03500612
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.93764310
20PPAR signaling pathway_Homo sapiens_hsa033201.92011436
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91712858
22Sulfur metabolism_Homo sapiens_hsa009201.78041584
23Peroxisome_Homo sapiens_hsa041461.77335800
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76250821
25Retinol metabolism_Homo sapiens_hsa008301.74152933
26Butanoate metabolism_Homo sapiens_hsa006501.67621085
27Starch and sucrose metabolism_Homo sapiens_hsa005001.61759597
28beta-Alanine metabolism_Homo sapiens_hsa004101.61607243
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.60984051
30Fatty acid metabolism_Homo sapiens_hsa012121.58318138
31Propanoate metabolism_Homo sapiens_hsa006401.55410912
32Bile secretion_Homo sapiens_hsa049761.54836689
33ABC transporters_Homo sapiens_hsa020101.51603250
34Fat digestion and absorption_Homo sapiens_hsa049751.48646164
35Selenocompound metabolism_Homo sapiens_hsa004501.46368390
36Phenylalanine metabolism_Homo sapiens_hsa003601.38633809
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27335589
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11090010
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09379276
40Tyrosine metabolism_Homo sapiens_hsa003501.08730083
41Vitamin digestion and absorption_Homo sapiens_hsa049771.08200118
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07828875
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07726538
44Pyruvate metabolism_Homo sapiens_hsa006201.05230573
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.03685509
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.02941837
47Glutathione metabolism_Homo sapiens_hsa004801.02198905
48Carbon metabolism_Homo sapiens_hsa012000.96058131
49Folate biosynthesis_Homo sapiens_hsa007900.89472158
50Biosynthesis of amino acids_Homo sapiens_hsa012300.88878158
51Glycerolipid metabolism_Homo sapiens_hsa005610.87767757
52Fatty acid elongation_Homo sapiens_hsa000620.87525507
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86350754
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85048258
55Sphingolipid metabolism_Homo sapiens_hsa006000.84917986
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84206883
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83960087
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.81772456
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81532938
60Arginine and proline metabolism_Homo sapiens_hsa003300.79380200
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70255087
62Lysine degradation_Homo sapiens_hsa003100.70082401
63Sulfur relay system_Homo sapiens_hsa041220.68024257
64Pentose phosphate pathway_Homo sapiens_hsa000300.66950346
65Galactose metabolism_Homo sapiens_hsa000520.66103377
66Ether lipid metabolism_Homo sapiens_hsa005650.65435108
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.63026003
68Pancreatic secretion_Homo sapiens_hsa049720.60335762
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59829321
70Steroid biosynthesis_Homo sapiens_hsa001000.59711179
71Other glycan degradation_Homo sapiens_hsa005110.53394172
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52130485
73Prion diseases_Homo sapiens_hsa050200.50426209
74Fatty acid biosynthesis_Homo sapiens_hsa000610.45694541
75Renin-angiotensin system_Homo sapiens_hsa046140.45690778
76Fructose and mannose metabolism_Homo sapiens_hsa000510.43849935
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43302207
78Vitamin B6 metabolism_Homo sapiens_hsa007500.42511665
79Insulin resistance_Homo sapiens_hsa049310.40853652
80Lysosome_Homo sapiens_hsa041420.40376340
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.35767758
82Pertussis_Homo sapiens_hsa051330.35309600
83Platelet activation_Homo sapiens_hsa046110.33022184
84Asthma_Homo sapiens_hsa053100.27626072
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27398725
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27324688
87Metabolic pathways_Homo sapiens_hsa011000.26956198
88Mineral absorption_Homo sapiens_hsa049780.22876333
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20883826
90Renin secretion_Homo sapiens_hsa049240.20754292
91Thyroid cancer_Homo sapiens_hsa052160.18123406
92One carbon pool by folate_Homo sapiens_hsa006700.17880714
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.17853587
94Leishmaniasis_Homo sapiens_hsa051400.17759256
95Linoleic acid metabolism_Homo sapiens_hsa005910.16757046
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.16500370
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16362179
98Arachidonic acid metabolism_Homo sapiens_hsa005900.16354712
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.15907284
100Osteoclast differentiation_Homo sapiens_hsa043800.15823324
101Tight junction_Homo sapiens_hsa045300.15314872
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13203579
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12541060
104Hepatitis C_Homo sapiens_hsa051600.11192499
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09115069
106Inositol phosphate metabolism_Homo sapiens_hsa005620.08063395
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.07490093
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.07024684
109Amoebiasis_Homo sapiens_hsa051460.06689561
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06211775
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.05450714
112Autoimmune thyroid disease_Homo sapiens_hsa053200.05017409
113Toxoplasmosis_Homo sapiens_hsa051450.04290927
114African trypanosomiasis_Homo sapiens_hsa051430.02627081
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.02396702
116Legionellosis_Homo sapiens_hsa051340.01619290
117Protein digestion and absorption_Homo sapiens_hsa049740.01268774
118AMPK signaling pathway_Homo sapiens_hsa041520.01178532
119Malaria_Homo sapiens_hsa051440.01164500
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0015793

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