HPGDS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)7.69669078
2G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.25385836
3thrombin receptor signaling pathway (GO:0070493)7.14565700
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.02073039
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.02073039
6positive regulation by organism of defense response of other organism involved in symbiotic interact7.02073039
7modulation by symbiont of host immune response (GO:0052553)7.02073039
8positive regulation by symbiont of host defense response (GO:0052509)7.02073039
9modulation by symbiont of host defense response (GO:0052031)7.02073039
10regulation of interferon-beta biosynthetic process (GO:0045357)6.42202446
11macrophage activation involved in immune response (GO:0002281)6.33633898
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.27190847
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.72788935
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.72788935
15response to inactivity (GO:0014854)5.61867228
16dendritic cell chemotaxis (GO:0002407)5.61445211
17purinergic nucleotide receptor signaling pathway (GO:0035590)5.51572168
18regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.35593021
19positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.27499844
20T cell migration (GO:0072678)5.12524761
21macrophage activation (GO:0042116)5.12013123
22negative regulation of bone remodeling (GO:0046851)4.97858471
23positive regulation of chemokine secretion (GO:0090197)4.97573720
24neutrophil activation involved in immune response (GO:0002283)4.95282984
25negative regulation of type 2 immune response (GO:0002829)4.91270478
26positive regulation of alpha-beta T cell proliferation (GO:0046641)4.84428490
27regulation of T cell chemotaxis (GO:0010819)4.82359502
28positive regulation of T cell chemotaxis (GO:0010820)4.82359502
29positive regulation of interferon-alpha production (GO:0032727)4.80138949
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76015851
31regulation of B cell receptor signaling pathway (GO:0050855)4.75451955
32regulation of cellular extravasation (GO:0002691)4.64178913
33regulation of interferon-alpha production (GO:0032647)4.54197205
34response to host immune response (GO:0052572)4.52637631
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.52637631
36G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.50976951
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.42236106
38interkinetic nuclear migration (GO:0022027)4.38725250
39myeloid cell activation involved in immune response (GO:0002275)4.37315780
40dendritic cell migration (GO:0036336)4.31259849
41definitive hemopoiesis (GO:0060216)4.31169712
42positive regulation of antigen processing and presentation (GO:0002579)4.27831193
43negative regulation of tissue remodeling (GO:0034104)4.25477231
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.24711110
45lipoxygenase pathway (GO:0019372)4.24618856
46monocyte chemotaxis (GO:0002548)4.22144562
47regulation of chemokine secretion (GO:0090196)4.18189109
48pinocytosis (GO:0006907)4.15781427
49response to host (GO:0075136)4.15691070
50response to host defenses (GO:0052200)4.15691070
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.15691070
52purinergic receptor signaling pathway (GO:0035587)4.11878929
53regulation of T-helper 1 type immune response (GO:0002825)4.10722130
54response to muramyl dipeptide (GO:0032495)4.05966443
55eosinophil chemotaxis (GO:0048245)4.02748478
56negative regulation of granulocyte differentiation (GO:0030853)4.00788812
57positive regulation of T-helper 1 type immune response (GO:0002827)3.99863308
58regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.94992142
59macrophage chemotaxis (GO:0048246)3.90844026
60response to peptidoglycan (GO:0032494)3.89944543
61lymphocyte chemotaxis (GO:0048247)3.79943520
62regulation of hypersensitivity (GO:0002883)3.70976131
63phagocytosis, engulfment (GO:0006911)3.69542617
64regulation of antigen processing and presentation (GO:0002577)3.68703350
65regulation of alpha-beta T cell proliferation (GO:0046640)3.66127250
66positive regulation of T cell migration (GO:2000406)3.65585933
67granulocyte activation (GO:0036230)3.62985912
68glycosphingolipid catabolic process (GO:0046479)3.58843174
69DNA ligation (GO:0006266)3.56398186
70I-kappaB phosphorylation (GO:0007252)3.54100751
71response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.50739241
72eosinophil migration (GO:0072677)3.50270643
73neutrophil activation (GO:0042119)3.49921183
74regulation of lymphocyte chemotaxis (GO:1901623)3.49463254
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49391153
76negative regulation of cell killing (GO:0031342)3.49391153
77cytidine deamination (GO:0009972)3.46995017
78cytidine metabolic process (GO:0046087)3.46995017
79cytidine catabolic process (GO:0006216)3.46995017
80negative regulation of mast cell activation (GO:0033004)3.45660772
81* cyclooxygenase pathway (GO:0019371)3.44693498
82regulation of interleukin-8 biosynthetic process (GO:0045414)3.40543874
83hyaluronan catabolic process (GO:0030214)3.38893247
84regulation of mast cell degranulation (GO:0043304)3.38182226
85ceramide catabolic process (GO:0046514)3.37483268
86cellular response to exogenous dsRNA (GO:0071360)3.37148546
87cardiolipin metabolic process (GO:0032048)3.37104631
88regulation of mast cell activation involved in immune response (GO:0033006)3.34524711
89sleep (GO:0030431)3.34124843
90positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.32635944
91regulation of T cell migration (GO:2000404)3.30456614
92positive regulation of B cell differentiation (GO:0045579)3.26392107
93positive regulation of interferon-beta production (GO:0032728)3.26227239
94negative regulation of erythrocyte differentiation (GO:0045647)3.24574045
95positive regulation of granulocyte differentiation (GO:0030854)3.22353970
96negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.22102012
97mature B cell differentiation involved in immune response (GO:0002313)3.18621357
98glycolipid catabolic process (GO:0019377)3.17845547
99myeloid leukocyte activation (GO:0002274)3.17767750
100negative thymic T cell selection (GO:0045060)3.16513501
101tolerance induction (GO:0002507)3.16331307
102parturition (GO:0007567)3.15026192
103regulation of mast cell activation (GO:0033003)3.14193571
104response to interleukin-15 (GO:0070672)3.12274995
105positive regulation of megakaryocyte differentiation (GO:0045654)3.11483237
106negative regulation of interleukin-6 production (GO:0032715)3.11443388
107immunoglobulin mediated immune response (GO:0016064)3.11327886
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11194448
109positive regulation of interleukin-1 beta secretion (GO:0050718)3.09494959
110cellular response to interleukin-15 (GO:0071350)3.07312255
111regulation of regulated secretory pathway (GO:1903305)3.07220088
112germinal center formation (GO:0002467)3.04414171
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.04359281
114B cell receptor signaling pathway (GO:0050853)3.03886794
115acrosome assembly (GO:0001675)3.02603988
116positive regulation of tumor necrosis factor production (GO:0032760)3.02327695
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98066522
118negative regulation of bone resorption (GO:0045779)2.98043882
119positive regulation of cellular amide metabolic process (GO:0034250)2.97629360
120positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.97588148
121mast cell activation (GO:0045576)2.96815540
122endothelium development (GO:0003158)2.96300784
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96281015
124lymphocyte migration (GO:0072676)2.95219847
125positive regulation of mast cell degranulation (GO:0043306)2.94689505
126regulation of T cell receptor signaling pathway (GO:0050856)2.94378491
127positive regulation of lymphocyte migration (GO:2000403)2.93121588
128respiratory burst (GO:0045730)2.92663989
129positive regulation of macrophage differentiation (GO:0045651)2.91719674
130positive regulation of gamma-delta T cell activation (GO:0046645)2.90542076
131negative T cell selection (GO:0043383)2.86297562
132megakaryocyte development (GO:0035855)2.85374229
133positive regulation of interleukin-1 secretion (GO:0050716)2.84503331
134negative regulation of interleukin-17 production (GO:0032700)2.83670267
135positive regulation of T cell differentiation in thymus (GO:0033089)2.82844181
136B cell differentiation (GO:0030183)2.79976270
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78730762
138regulation of lymphocyte migration (GO:2000401)2.77146162
139positive regulation of monocyte chemotaxis (GO:0090026)2.76818399
140regulation of macrophage differentiation (GO:0045649)2.73516561
141positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72963955
142mature B cell differentiation (GO:0002335)2.72562305
143negative regulation of leukocyte mediated immunity (GO:0002704)2.71512683
144oligosaccharide catabolic process (GO:0009313)2.71310876
145regulation of B cell apoptotic process (GO:0002902)2.70169502
146negative regulation of myotube differentiation (GO:0010832)2.69796167
147neutrophil mediated immunity (GO:0002446)2.69138785
148negative regulation of DNA-templated transcription, elongation (GO:0032785)2.68502890
149negative regulation of nitric oxide biosynthetic process (GO:0045019)2.68475545
150pore complex assembly (GO:0046931)2.68167827
151response to ATP (GO:0033198)2.67675771
152regulation of gamma-delta T cell differentiation (GO:0045586)2.66842065
153transcription from mitochondrial promoter (GO:0006390)2.64734076
154mannose metabolic process (GO:0006013)2.64241504
155lytic vacuole organization (GO:0080171)2.63643656
156lysosome organization (GO:0007040)2.63643656
157pyrimidine ribonucleoside catabolic process (GO:0046133)2.62005691
158regulation of interleukin-1 beta secretion (GO:0050706)2.61259218
159amino sugar catabolic process (GO:0046348)2.61063024
160regulation of germinal center formation (GO:0002634)2.60245239
161positive regulation of mast cell activation (GO:0033005)2.60012178
162regulation of leukocyte degranulation (GO:0043300)2.58891903
163negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.58250297
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58055102
165regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.57427785
166adenosine receptor signaling pathway (GO:0001973)2.56648971
167G-protein coupled receptor internalization (GO:0002031)2.55562788
168regulation of mononuclear cell migration (GO:0071675)2.55346348
169regulation of interferon-gamma biosynthetic process (GO:0045072)2.53979768
170phosphatidylglycerol biosynthetic process (GO:0006655)2.52948436
171membrane invagination (GO:0010324)2.52280678
172positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.51148911
173regulation of monocyte chemotaxis (GO:0090025)2.50397950
174positive regulation of mast cell activation involved in immune response (GO:0033008)2.50018749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.69267885
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.92114346
3IRF8_27001747_Chip-Seq_BMDM_Mouse4.72198347
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.68174297
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.46273543
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.71866804
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.46010616
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32876824
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19872672
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18925520
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78926289
12SCL_19346495_ChIP-Seq_HPC-7_Human2.78017535
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69633032
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68877442
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45324449
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.44796465
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39651565
18VDR_22108803_ChIP-Seq_LS180_Human2.39612927
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36162312
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26451380
21UTX_26944678_Chip-Seq_JUKART_Human2.22115960
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13860033
23* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.13100406
24SPI1_23127762_ChIP-Seq_K562_Human2.07604792
25GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.05190466
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04119280
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.02499522
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97390194
29GATA3_27048872_Chip-Seq_THYMUS_Human1.92073974
30VDR_24787735_ChIP-Seq_THP-1_Human1.87280586
31SPI1_23547873_ChIP-Seq_NB4_Human1.83676824
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79907815
33PU_27001747_Chip-Seq_BMDM_Mouse1.78596785
34RUNX_20019798_ChIP-Seq_JUKART_Human1.78518351
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77532804
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75539041
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73829222
38GATA1_19941826_ChIP-Seq_K562_Human1.73512098
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72077230
40GATA1_22025678_ChIP-Seq_K562_Human1.71637715
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69579843
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69420550
43* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68025588
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65034476
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64232998
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63791517
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58500251
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58369292
49MAF_26560356_Chip-Seq_TH1_Human1.55217091
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53750075
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.53244062
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45741717
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.44821481
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42953063
55VDR_23849224_ChIP-Seq_CD4+_Human1.42171493
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.41952077
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38533928
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38456384
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37809083
60FOXP3_21729870_ChIP-Seq_TREG_Human1.37378420
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37045483
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36094856
63VDR_21846776_ChIP-Seq_THP-1_Human1.35757249
64MYC_22102868_ChIP-Seq_BL_Human1.35698245
65VDR_24763502_ChIP-Seq_THP-1_Human1.33115496
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32779814
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30508157
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.30387710
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29643320
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28185126
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28033701
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27562420
73GBX2_23144817_ChIP-Seq_PC3_Human1.24956650
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24779730
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24691659
76ELK1_19687146_ChIP-ChIP_HELA_Human1.22388707
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20352640
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19870718
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19234462
80IRF1_19129219_ChIP-ChIP_H3396_Human1.14895042
81AHR_22903824_ChIP-Seq_MCF-7_Human1.14287977
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13621905
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.13513932
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.13156056
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12606520
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12529699
87GATA2_19941826_ChIP-Seq_K562_Human1.11399364
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10606563
89STAT1_20625510_ChIP-Seq_HELA_Human1.10254932
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09389492
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07920135
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07620289
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06119328
94SPI1_20517297_ChIP-Seq_HL60_Human1.05898401
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.05708050
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05557454
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05107625
98MAF_26560356_Chip-Seq_TH2_Human1.04847501
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.04131304
100DROSHA_22980978_ChIP-Seq_HELA_Human1.03098063
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02465418
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02069329
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00686181
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00039388
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.99975444
106MYB_26560356_Chip-Seq_TH2_Human0.98731100
107TP53_16413492_ChIP-PET_HCT116_Human0.98170539
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97794073
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96589146
110* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95174042
111* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94710115
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94686587
113* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94551170
114PU1_27457419_Chip-Seq_LIVER_Mouse0.94369077
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.92725713
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92271222
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91941553
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91329673
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91307727
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89612859
121GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89489334
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87952202
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87890114
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.87805478
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87777567
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85744304
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85320109
128* GATA3_26560356_Chip-Seq_TH2_Human0.85199804
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84807623
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.84575491
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84539907
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.84395474
133SMRT_27268052_Chip-Seq_Bcells_Human0.84055659
134MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83944303
135CJUN_26792858_Chip-Seq_BT549_Human0.83506425
136STAT3_18555785_Chip-Seq_ESCs_Mouse0.82051174
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.81693269
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.81515777
139MYB_26560356_Chip-Seq_TH1_Human0.81355842
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.81101811
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80827428
142* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80144980
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79529129
144GABP_17652178_ChIP-ChIP_JURKAT_Human0.79298798
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.78858414
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78755219
147EST1_17652178_ChIP-ChIP_JURKAT_Human0.78647473
148TCF4_22108803_ChIP-Seq_LS180_Human0.78188811
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77916325
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77650211
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.77477061
152KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.77030815
153P300_27268052_Chip-Seq_Bcells_Human0.76093660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.30792895
2MP0000569_abnormal_digit_pigmentation4.46752939
3MP0006082_CNS_inflammation3.96282112
4MP0003191_abnormal_cellular_cholesterol3.84046550
5MP0004147_increased_porphyrin_level3.70626033
6MP0001835_abnormal_antigen_presentation3.65553218
7MP0003172_abnormal_lysosome_physiology3.64226332
8MP0002148_abnormal_hypersensitivity_rea2.94833514
9MP0003303_peritoneal_inflammation2.86776838
10MP0002419_abnormal_innate_immunity2.86354333
11MP0005464_abnormal_platelet_physiology2.85309589
12MP0001545_abnormal_hematopoietic_system2.76402880
13MP0005397_hematopoietic_system_phenotyp2.76402880
14MP0005671_abnormal_response_to2.68065844
15MP0003436_decreased_susceptibility_to2.65207638
16MP0005174_abnormal_tail_pigmentation2.63374553
17MP0005000_abnormal_immune_tolerance2.46467609
18MP0000015_abnormal_ear_pigmentation2.43218738
19MP0003329_amyloid_beta_deposits2.41916648
20MP0003183_abnormal_peptide_metabolism2.35732613
21MP0002452_abnormal_antigen_presenting2.34086022
22MP0001542_abnormal_bone_strength2.32539472
23MP0003690_abnormal_glial_cell2.22723588
24MP0001800_abnormal_humoral_immune2.18003477
25* MP0002723_abnormal_immune_serum2.13975323
26MP0003656_abnormal_erythrocyte_physiolo2.12142646
27MP0002254_reproductive_system_inflammat2.11648869
28MP0004381_abnormal_hair_follicle1.97286068
29MP0005387_immune_system_phenotype1.97172913
30MP0001790_abnormal_immune_system1.97172913
31MP0005025_abnormal_response_to1.96794896
32MP0001986_abnormal_taste_sensitivity1.94126218
33MP0001819_abnormal_immune_cell1.90781206
34MP0002420_abnormal_adaptive_immunity1.89769089
35MP0008004_abnormal_stomach_pH1.79388628
36MP0003724_increased_susceptibility_to1.73422277
37MP0005167_abnormal_blood-brain_barrier1.71611353
38MP0002277_abnormal_respiratory_mucosa1.69574159
39MP0001533_abnormal_skeleton_physiology1.68845929
40MP0001851_eye_inflammation1.66923652
41MP0000371_diluted_coat_color1.64006722
42MP0009785_altered_susceptibility_to1.63444972
43MP0008057_abnormal_DNA_replication1.59782262
44MP0009840_abnormal_foam_cell1.56379231
45MP0005409_darkened_coat_color1.53284602
46MP0002405_respiratory_system_inflammati1.52700722
47MP0003300_gastrointestinal_ulcer1.50258558
48MP0000465_gastrointestinal_hemorrhage1.47586844
49MP0004885_abnormal_endolymph1.44602246
50MP0002998_abnormal_bone_remodeling1.35793333
51MP0005310_abnormal_salivary_gland1.34545348
52MP0002095_abnormal_skin_pigmentation1.28757532
53* MP0001845_abnormal_inflammatory_respons1.28159025
54MP0008469_abnormal_protein_level1.27228717
55MP0000716_abnormal_immune_system1.26314903
56MP0002090_abnormal_vision1.26266806
57MP0005646_abnormal_pituitary_gland1.25638353
58MP0002876_abnormal_thyroid_physiology1.25395756
59MP0001853_heart_inflammation1.24371467
60MP0005257_abnormal_intraocular_pressure1.23992247
61MP0000689_abnormal_spleen_morphology1.23735668
62MP0004947_skin_inflammation1.23355841
63MP0002396_abnormal_hematopoietic_system1.22385538
64MP0000343_altered_response_to1.15895068
65MP0001501_abnormal_sleep_pattern1.14144792
66MP0005171_absent_coat_pigmentation1.13369537
67MP0005165_increased_susceptibility_to1.12464023
68MP0003136_yellow_coat_color1.11922960
69MP0003045_fibrosis1.11833102
70MP0004883_abnormal_blood_vessel1.10778253
71MP0002139_abnormal_hepatobiliary_system1.09265346
72MP0002398_abnormal_bone_marrow1.07291793
73MP0003075_altered_response_to1.06590724
74MP0002166_altered_tumor_susceptibility1.03865400
75MP0003828_pulmonary_edema1.03800820
76MP0000685_abnormal_immune_system1.02430944
77MP0000604_amyloidosis0.99691363
78MP0004510_myositis0.99106151
79MP0005075_abnormal_melanosome_morpholog0.98774585
80MP0002075_abnormal_coat/hair_pigmentati0.97494359
81MP0009333_abnormal_splenocyte_physiolog0.96989465
82MP0002429_abnormal_blood_cell0.95727959
83MP0010155_abnormal_intestine_physiology0.94675643
84MP0003806_abnormal_nucleotide_metabolis0.94250907
85MP0000372_irregular_coat_pigmentation0.93555384
86MP0000920_abnormal_myelination0.92069317
87* MP0002722_abnormal_immune_system0.92052931
88MP0002138_abnormal_hepatobiliary_system0.90663093
89MP0008873_increased_physiological_sensi0.89968921
90MP0002933_joint_inflammation0.89712622
91MP0009379_abnormal_foot_pigmentation0.89546737
92MP0004130_abnormal_muscle_cell0.87788065
93MP0001186_pigmentation_phenotype0.87303317
94MP0005166_decreased_susceptibility_to0.87086311
95MP0002006_tumorigenesis0.87085877
96MP0003448_altered_tumor_morphology0.83911972
97MP0000681_abnormal_thyroid_gland0.83120422
98MP0001764_abnormal_homeostasis0.80378820
99MP0005390_skeleton_phenotype0.80132180
100MP0005164_abnormal_response_to0.79828172
101MP0000249_abnormal_blood_vessel0.79329919
102MP0005084_abnormal_gallbladder_morpholo0.78456551
103MP0005332_abnormal_amino_acid0.78344012
104MP0009765_abnormal_xenobiotic_induced0.78232501
105MP0000703_abnormal_thymus_morphology0.76441757
106MP0000383_abnormal_hair_follicle0.75547687
107MP0001919_abnormal_reproductive_system0.75407614
108MP0002638_abnormal_pupillary_reflex0.75168922
109MP0009278_abnormal_bone_marrow0.74954011
110MP0004808_abnormal_hematopoietic_stem0.74469326
111MP0003453_abnormal_keratinocyte_physiol0.74466686
112MP0002019_abnormal_tumor_incidence0.74151447
113MP0003718_maternal_effect0.73341173
114MP0009764_decreased_sensitivity_to0.73228353
115MP0003943_abnormal_hepatobiliary_system0.72830461
116MP0005197_abnormal_uvea_morphology0.72242373
117MP0003866_abnormal_defecation0.71443205
118MP0005670_abnormal_white_adipose0.70631799
119MP0002928_abnormal_bile_duct0.69934462
120MP0000858_altered_metastatic_potential0.69843188
121MP0003795_abnormal_bone_structure0.69255945
122MP0001873_stomach_inflammation0.68881692
123MP0003878_abnormal_ear_physiology0.68211718
124MP0005377_hearing/vestibular/ear_phenot0.68211718
125MP0009643_abnormal_urine_homeostasis0.68123566
126MP0006072_abnormal_retinal_apoptosis0.66817110
127MP0000367_abnormal_coat/_hair0.66108059
128MP0003566_abnormal_cell_adhesion0.65946403
129MP0010307_abnormal_tumor_latency0.65227257
130MP0009763_increased_sensitivity_to0.65189222
131MP0000230_abnormal_systemic_arterial0.64969082
132MP0001324_abnormal_eye_pigmentation0.64852184
133MP0003763_abnormal_thymus_physiology0.64795205
134MP0003638_abnormal_response/metabolism_0.63621621
135MP0002060_abnormal_skin_morphology0.62552502
136MP0001188_hyperpigmentation0.62541406
137MP0003252_abnormal_bile_duct0.60064184

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.16310965
2Cerebral palsy (HP:0100021)6.10021295
3Recurrent abscess formation (HP:0002722)5.68429217
4Abnormality of glycolipid metabolism (HP:0010969)5.48457311
5Abnormality of liposaccharide metabolism (HP:0010968)5.48457311
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.48457311
7Vacuolated lymphocytes (HP:0001922)5.41944528
8Increased cerebral lipofuscin (HP:0011813)5.36230954
9Glomerulonephritis (HP:0000099)5.29580489
10Increased neuronal autofluorescent lipopigment (HP:0002074)5.23094931
11Recurrent bacterial skin infections (HP:0005406)5.21246040
12Growth hormone excess (HP:0000845)5.20977728
13Stomach cancer (HP:0012126)4.88761942
14Dysostosis multiplex (HP:0000943)4.73742075
15Retinal atrophy (HP:0001105)4.09946685
16IgG deficiency (HP:0004315)4.04836242
17Eczematoid dermatitis (HP:0000976)4.04237909
18Agammaglobulinemia (HP:0004432)4.03928382
19Disinhibition (HP:0000734)4.01589484
20Axonal loss (HP:0003447)3.95803176
21Abnormality of B cell number (HP:0010975)3.94964126
22Prostate neoplasm (HP:0100787)3.92604676
23Seborrheic dermatitis (HP:0001051)3.85865647
24Global brain atrophy (HP:0002283)3.79694104
25Agnosia (HP:0010524)3.79568076
26B lymphocytopenia (HP:0010976)3.78070289
27Joint swelling (HP:0001386)3.76897352
28Long clavicles (HP:0000890)3.61397374
29Redundant skin (HP:0001582)3.59419035
30Abnormality of T cell physiology (HP:0011840)3.54223580
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.49778355
32Abnormality of polysaccharide metabolism (HP:0011012)3.49778355
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.49778355
34Urethral obstruction (HP:0000796)3.49570532
35Mucopolysacchariduria (HP:0008155)3.39965473
36Urinary glycosaminoglycan excretion (HP:0003541)3.39965473
37Colitis (HP:0002583)3.38934854
38Complement deficiency (HP:0004431)3.34331036
39Autoimmune thrombocytopenia (HP:0001973)3.27643490
40Glucose intolerance (HP:0000833)3.25241849
41Thick nail (HP:0001805)3.25230457
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.24362285
43Arterial tortuosity (HP:0005116)3.18499178
44Upper motor neuron abnormality (HP:0002127)3.17479570
45Abnormality of T cells (HP:0002843)3.16645631
46Abnormality of macrophages (HP:0004311)3.12366287
47Neurodegeneration (HP:0002180)3.12345346
48Recurrent skin infections (HP:0001581)3.11835657
49Abnormal glucose tolerance (HP:0001952)3.09619673
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.00976917
51Abnormality of male internal genitalia (HP:0000022)2.99856523
52Hypoplasia of the pons (HP:0012110)2.95794713
53Inflammation of the large intestine (HP:0002037)2.88008046
54Granulocytopenia (HP:0001913)2.78674722
55Abnormality of T cell number (HP:0011839)2.78003475
56Gingivitis (HP:0000230)2.70984696
57Vascular tortuosity (HP:0004948)2.70582582
58Nephritis (HP:0000123)2.69798324
59Abnormality of complement system (HP:0005339)2.67615020
60Premature skin wrinkling (HP:0100678)2.64648263
61Stomatitis (HP:0010280)2.63815963
62Abnormality of the pons (HP:0007361)2.61164223
63Hepatosplenomegaly (HP:0001433)2.59423894
64Recurrent gram-negative bacterial infections (HP:0005420)2.58665722
65Mutism (HP:0002300)2.56205277
66Recurrent fungal infections (HP:0002841)2.55847855
67Periodontitis (HP:0000704)2.50818479
68Ocular albinism (HP:0001107)2.50654068
69Panhypogammaglobulinemia (HP:0003139)2.49725355
70Gastrointestinal inflammation (HP:0004386)2.49596059
71Abnormal platelet function (HP:0011869)2.47798205
72Impaired platelet aggregation (HP:0003540)2.47798205
73Spondylolisthesis (HP:0003302)2.45528158
74Neutropenia (HP:0001875)2.44882812
75Leukocytosis (HP:0001974)2.44838716
76Mediastinal lymphadenopathy (HP:0100721)2.43914046
77Petechiae (HP:0000967)2.43286212
78Pathologic fracture (HP:0002756)2.42750748
79Orchitis (HP:0100796)2.42406856
80Chronic diarrhea (HP:0002028)2.42122509
81Myositis (HP:0100614)2.42031118
82Clumsiness (HP:0002312)2.41657716
83Generalized hypopigmentation of hair (HP:0011358)2.40821684
84Recurrent viral infections (HP:0004429)2.40483137
85Basal ganglia calcification (HP:0002135)2.39790058
86IgM deficiency (HP:0002850)2.39769207
87Progressive visual loss (HP:0000529)2.39648412
88Abnormality of iron homeostasis (HP:0011031)2.37668364
89T lymphocytopenia (HP:0005403)2.37648344
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.37159656
91Purpura (HP:0000979)2.34440891
92Neurofibrillary tangles (HP:0002185)2.34308955
93Anterior segment dysgenesis (HP:0007700)2.34109389
94Chronic obstructive pulmonary disease (HP:0006510)2.33031935
95Obstructive lung disease (HP:0006536)2.33031935
96Optic neuritis (HP:0100653)2.31820929
97Retrobulbar optic neuritis (HP:0100654)2.31820929
98Chronic mucocutaneous candidiasis (HP:0002728)2.29051518
99Recurrent cutaneous fungal infections (HP:0011370)2.29051518
100Autoimmune hemolytic anemia (HP:0001890)2.27654094
101Increased serum ferritin (HP:0003281)2.27352414
102Intestinal fistula (HP:0100819)2.25520846
103Generalized hypopigmentation (HP:0007513)2.24983452
104Peripheral demyelination (HP:0011096)2.23887448
105Inappropriate behavior (HP:0000719)2.22684353
106Bone pain (HP:0002653)2.22154093
107Hematochezia (HP:0002573)2.19913379
108Epistaxis (HP:0000421)2.19420613
109Intestinal atresia (HP:0011100)2.18917065
110Progressive neurologic deterioration (HP:0002344)2.15696096
111Thoracic kyphosis (HP:0002942)2.15493386
112Myocardial infarction (HP:0001658)2.12733135
113Hyperpituitarism (HP:0010514)2.09604206
114Birth length less than 3rd percentile (HP:0003561)2.09595625
115Neuronal loss in central nervous system (HP:0002529)2.08049742
116Prolonged bleeding time (HP:0003010)2.06558835
117Iris hypopigmentation (HP:0007730)2.06337656
118Premature loss of primary teeth (HP:0006323)2.05109374
119Rectal fistula (HP:0100590)2.04876295
120Rectovaginal fistula (HP:0000143)2.04876295
121Lip pit (HP:0100267)2.04763493
122Abnormality of eosinophils (HP:0001879)2.04603930
123Eosinophilia (HP:0001880)2.04320372
124Osteomyelitis (HP:0002754)2.03384494
125Spontaneous hematomas (HP:0007420)2.03193226
126Submucous cleft hard palate (HP:0000176)2.03107459
127Loss of speech (HP:0002371)2.02502113
128Abnormality of transition element cation homeostasis (HP:0011030)2.02425541
129Pustule (HP:0200039)2.01821435
130Meningitis (HP:0001287)2.01566024
131Abnormality of the axillary hair (HP:0100134)2.01490435
132Abnormality of secondary sexual hair (HP:0009888)2.01490435
133Increased IgM level (HP:0003496)2.01466006
134Increased muscle lipid content (HP:0009058)2.01397077
135Pulmonary fibrosis (HP:0002206)2.00903660
136Acne (HP:0001061)2.00325115
137Disproportionate tall stature (HP:0001519)2.00266149
138Cellulitis (HP:0100658)1.99865543
139Elevated erythrocyte sedimentation rate (HP:0003565)1.95610911
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.94748397
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94285294
142Dicarboxylic aciduria (HP:0003215)1.94285294
143Abnormality of the prostate (HP:0008775)1.93726113
144Thyroiditis (HP:0100646)1.93059225
145Recurrent pneumonia (HP:0006532)1.92209214
146Acute lymphatic leukemia (HP:0006721)1.92149386
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91096133
148Chest pain (HP:0100749)1.90855515
149Aplastic anemia (HP:0001915)1.89133013
150Personality changes (HP:0000751)1.88921031
151Postural instability (HP:0002172)1.87965608
152J-shaped sella turcica (HP:0002680)1.86664097
153Opisthotonus (HP:0002179)1.85110069
154Impulsivity (HP:0100710)1.83755475
155Hyperammonemia (HP:0001987)1.83643580
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.83447701
157Osteolytic defects of the hand bones (HP:0009699)1.83447701
158Thrombocytosis (HP:0001894)1.80945849
159Recurrent bronchitis (HP:0002837)1.80334528
160Abnormality of the periventricular white matter (HP:0002518)1.80122878
161Vasculitis (HP:0002633)1.80122400
162Thickened calvaria (HP:0002684)1.80020308
163Abnormality of the columella (HP:0009929)1.79583887
164Spastic paraparesis (HP:0002313)1.79225331
165Clubbing of toes (HP:0100760)1.78198492
166IgA deficiency (HP:0002720)1.78191389
167Carpal bone hypoplasia (HP:0001498)1.77375026
168Cutaneous melanoma (HP:0012056)1.75436479
169Rhabdomyolysis (HP:0003201)1.73867234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.75841165
2RIPK14.89283051
3BLK3.44944044
4GRK73.41189056
5MAP2K23.07049818
6PIK3CA3.05190831
7IRAK32.96185722
8GRK62.95899474
9RIPK42.76467574
10IRAK42.72327216
11MAPK152.43985985
12TYK22.40057654
13KIT2.13077201
14CSF1R2.11059075
15BCKDK2.08693246
16MAP3K142.06388325
17MAP2K31.98459195
18IKBKB1.91416197
19TXK1.87970615
20TBK11.78365772
21CDK31.78141320
22TLK11.72686322
23TNIK1.71111262
24ZAP701.68358946
25FES1.65676091
26MAP3K61.60731152
27CAMK1D1.57855914
28TAOK31.54623581
29EIF2AK21.53446951
30MAP4K11.49224491
31NEK91.45750518
32KDR1.40273208
33TRPM71.37517936
34CAMK1G1.35526793
35YES11.34705726
36ITK1.33954073
37IKBKE1.33845625
38LYN1.32219267
39BMPR21.31488903
40HCK1.31381821
41MAPKAPK51.29996556
42MAPK71.28068049
43INSRR1.27056131
44JAK11.25838815
45MAPK121.24004083
46STK101.23641569
47CLK11.23015886
48MAP3K71.21291915
49SYK1.15732859
50TESK21.13561066
51DAPK21.13536355
52TEC1.13085010
53LCK1.11405670
54SRPK11.08819027
55MAPKAPK31.05991897
56EIF2AK31.05429635
57MOS1.04203904
58MAP3K111.03626249
59BMPR1B1.00726903
60CSK1.00365468
61MAP3K131.00128119
62SCYL20.99484818
63MAP4K20.97870570
64NME20.96891355
65PINK10.96595158
66MATK0.95177240
67PDK20.94896534
68PLK40.90316481
69BRD40.89176831
70PIM10.89053944
71PKN10.87616463
72MAP3K30.87321497
73BTK0.86891489
74CAMKK20.85430018
75PIK3CG0.83364237
76EEF2K0.83296176
77SIK20.81010378
78CHUK0.79850137
79RPS6KA60.79792226
80RPS6KC10.78956612
81RPS6KL10.78956612
82ADRBK20.78441902
83ARAF0.78306804
84MAP2K10.76744753
85MAPK40.75476011
86RPS6KA40.72967181
87BUB10.72735195
88SGK20.71513502
89FLT30.68182141
90IGF1R0.68062877
91JAK20.67982212
92MAPKAPK20.61133440
93IRAK10.59638677
94MKNK10.59629380
95ERBB20.57747988
96GRK50.56213371
97MST40.55930879
98PASK0.54171348
99SGK30.53609241
100CDK60.53213319
101CASK0.52616748
102EGFR0.52134124
103TNK20.51802810
104FGR0.50812647
105PRKAA20.50013641
106JAK30.49465992
107CCNB10.49207319
108RPS6KA50.49008356
109NEK60.48628439
110IRAK20.47019079
111RPS6KA20.45536832
112ERBB30.45387294
113NLK0.43723982
114ZAK0.42964140
115RET0.42546995
116MAP3K90.41473942
117MAPK30.40600104
118PIM20.39266209
119PRKCQ0.38629680
120GSK3A0.38352993
121PRKCD0.37002302
122PDK10.36815938
123MAP3K10.36627628
124CAMK40.35377558
125NUAK10.34797252
126VRK10.34681743
127FYN0.33413258
128GRK10.33252213
129RPS6KA10.33193536
130BRAF0.32241614
131CAMK10.32205052
132ABL10.31953017
133PRKG10.31612536
134CDK80.31302936
135TIE10.30416446
136HIPK20.29138334
137INSR0.29080465
138ERN10.28423550
139CDK90.27866128
140CSNK2A10.27328419
141PAK40.27111404
142ABL20.25695183
143MAP2K60.25401053
144PBK0.24137199
145RPS6KB20.23994567
146RAF10.21446305

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.08315452
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.04570140
3Staphylococcus aureus infection_Homo sapiens_hsa051503.72212298
4Lysosome_Homo sapiens_hsa041423.21922229
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.92790443
6Osteoclast differentiation_Homo sapiens_hsa043802.64706891
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.30944384
8Leishmaniasis_Homo sapiens_hsa051402.25878170
9DNA replication_Homo sapiens_hsa030302.16475177
10Pertussis_Homo sapiens_hsa051331.96344061
11B cell receptor signaling pathway_Homo sapiens_hsa046621.93297239
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89517121
13Tuberculosis_Homo sapiens_hsa051521.79782177
14Homologous recombination_Homo sapiens_hsa034401.77419101
15Mismatch repair_Homo sapiens_hsa034301.75830200
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75304769
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.66398348
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62277237
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62220700
20Rheumatoid arthritis_Homo sapiens_hsa053231.60880775
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58982521
22Sphingolipid metabolism_Homo sapiens_hsa006001.53160041
23Nucleotide excision repair_Homo sapiens_hsa034201.45367138
24Phagosome_Homo sapiens_hsa041451.44445576
25Measles_Homo sapiens_hsa051621.43437521
26Antigen processing and presentation_Homo sapiens_hsa046121.35682713
27Base excision repair_Homo sapiens_hsa034101.31799347
28Hematopoietic cell lineage_Homo sapiens_hsa046401.29760447
29Ether lipid metabolism_Homo sapiens_hsa005651.29707695
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29061847
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24435692
32Influenza A_Homo sapiens_hsa051641.24348841
33Chemokine signaling pathway_Homo sapiens_hsa040621.22068673
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18488183
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16276411
36Malaria_Homo sapiens_hsa051441.16192866
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14473665
38Graft-versus-host disease_Homo sapiens_hsa053321.14410455
39Toxoplasmosis_Homo sapiens_hsa051451.13783031
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.12929637
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11651487
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10735628
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08842484
44Primary immunodeficiency_Homo sapiens_hsa053401.07596390
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07244084
46Legionellosis_Homo sapiens_hsa051341.03624247
47Salmonella infection_Homo sapiens_hsa051321.03480278
48ABC transporters_Homo sapiens_hsa020100.99087838
49Allograft rejection_Homo sapiens_hsa053300.97081107
50Platelet activation_Homo sapiens_hsa046110.95597745
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94814012
52Apoptosis_Homo sapiens_hsa042100.93289567
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.91349207
54Linoleic acid metabolism_Homo sapiens_hsa005910.87721835
55TNF signaling pathway_Homo sapiens_hsa046680.83370244
56Collecting duct acid secretion_Homo sapiens_hsa049660.81927084
57T cell receptor signaling pathway_Homo sapiens_hsa046600.81912516
58Complement and coagulation cascades_Homo sapiens_hsa046100.80889252
59Pancreatic cancer_Homo sapiens_hsa052120.80230518
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79513480
61Asthma_Homo sapiens_hsa053100.78878578
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.78054962
63Herpes simplex infection_Homo sapiens_hsa051680.76927678
64Hepatitis C_Homo sapiens_hsa051600.76665813
65Peroxisome_Homo sapiens_hsa041460.75591327
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75220565
67* Arachidonic acid metabolism_Homo sapiens_hsa005900.72812120
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.72093013
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70310724
70Chronic myeloid leukemia_Homo sapiens_hsa052200.69396321
71Endocytosis_Homo sapiens_hsa041440.68280508
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.67778347
73Purine metabolism_Homo sapiens_hsa002300.67182497
74Hepatitis B_Homo sapiens_hsa051610.66569427
75Spliceosome_Homo sapiens_hsa030400.66470054
76Prion diseases_Homo sapiens_hsa050200.64177457
77Ribosome_Homo sapiens_hsa030100.64134988
78Systemic lupus erythematosus_Homo sapiens_hsa053220.62550484
79Autoimmune thyroid disease_Homo sapiens_hsa053200.62367723
80Non-homologous end-joining_Homo sapiens_hsa034500.61985282
81African trypanosomiasis_Homo sapiens_hsa051430.61844763
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61740337
83Sulfur metabolism_Homo sapiens_hsa009200.60708995
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58581957
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56990666
86Inositol phosphate metabolism_Homo sapiens_hsa005620.56038632
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55955163
88Shigellosis_Homo sapiens_hsa051310.54912787
89Mineral absorption_Homo sapiens_hsa049780.52582584
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52556927
91RNA degradation_Homo sapiens_hsa030180.52298410
92Basal transcription factors_Homo sapiens_hsa030220.48429130
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46345124
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45337226
95Renin secretion_Homo sapiens_hsa049240.44740710
96Caffeine metabolism_Homo sapiens_hsa002320.44700707
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44042132
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42634632
99Pyrimidine metabolism_Homo sapiens_hsa002400.42509033
100Olfactory transduction_Homo sapiens_hsa047400.41831442
101Type II diabetes mellitus_Homo sapiens_hsa049300.41090400
102Morphine addiction_Homo sapiens_hsa050320.40069404
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39831046
104Calcium signaling pathway_Homo sapiens_hsa040200.39789283
105MAPK signaling pathway_Homo sapiens_hsa040100.39763112
106Acute myeloid leukemia_Homo sapiens_hsa052210.39264512
107Renin-angiotensin system_Homo sapiens_hsa046140.39036391
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.38257755
109Epstein-Barr virus infection_Homo sapiens_hsa051690.37854878
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.37350663
111Viral myocarditis_Homo sapiens_hsa054160.36257439
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35463076
113Dorso-ventral axis formation_Homo sapiens_hsa043200.35295839
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35283928
115Non-small cell lung cancer_Homo sapiens_hsa052230.35009603
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.33441889
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33073485
118Type I diabetes mellitus_Homo sapiens_hsa049400.31867935
119GnRH signaling pathway_Homo sapiens_hsa049120.31316471
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30825204
121Amoebiasis_Homo sapiens_hsa051460.30666070
122Prolactin signaling pathway_Homo sapiens_hsa049170.29010432
123Notch signaling pathway_Homo sapiens_hsa043300.28747291
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.27518369
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26948346
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26723847
127Regulation of autophagy_Homo sapiens_hsa041400.26178872
128VEGF signaling pathway_Homo sapiens_hsa043700.25702942
129Prostate cancer_Homo sapiens_hsa052150.25217964
130Ras signaling pathway_Homo sapiens_hsa040140.25064811
131Salivary secretion_Homo sapiens_hsa049700.25053991
132FoxO signaling pathway_Homo sapiens_hsa040680.24940318
133RNA transport_Homo sapiens_hsa030130.24083428

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »