HPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.61001162
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61001162
3L-phenylalanine metabolic process (GO:0006558)7.32727923
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.32727923
5aromatic amino acid family catabolic process (GO:0009074)6.88309972
6epoxygenase P450 pathway (GO:0019373)6.46119272
7tryptophan catabolic process (GO:0006569)6.25692748
8indole-containing compound catabolic process (GO:0042436)6.25692748
9indolalkylamine catabolic process (GO:0046218)6.25692748
10glyoxylate metabolic process (GO:0046487)6.11485846
11kynurenine metabolic process (GO:0070189)6.03899965
12omega-hydroxylase P450 pathway (GO:0097267)5.96288677
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.93062006
14tryptophan metabolic process (GO:0006568)5.89438081
15cysteine metabolic process (GO:0006534)5.82436731
16bile acid biosynthetic process (GO:0006699)5.77683644
17urea cycle (GO:0000050)5.43098553
18urea metabolic process (GO:0019627)5.43098553
19sulfur amino acid catabolic process (GO:0000098)5.38468964
20alpha-linolenic acid metabolic process (GO:0036109)5.37273238
21intestinal cholesterol absorption (GO:0030299)5.35380720
22lysine metabolic process (GO:0006553)5.31247776
23lysine catabolic process (GO:0006554)5.31247776
24serine family amino acid catabolic process (GO:0009071)5.29369503
25negative regulation of fibrinolysis (GO:0051918)5.25285704
26high-density lipoprotein particle remodeling (GO:0034375)5.20136547
27very-low-density lipoprotein particle assembly (GO:0034379)5.13435699
28protein carboxylation (GO:0018214)5.09927255
29peptidyl-glutamic acid carboxylation (GO:0017187)5.09927255
30regulation of fibrinolysis (GO:0051917)5.04792277
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02938175
32nitrogen cycle metabolic process (GO:0071941)5.01994069
33aromatic amino acid family metabolic process (GO:0009072)5.01455078
34homocysteine metabolic process (GO:0050667)4.97188052
35regulation of protein activation cascade (GO:2000257)4.96180373
36complement activation, alternative pathway (GO:0006957)4.95326446
37bile acid metabolic process (GO:0008206)4.90245490
38amino-acid betaine metabolic process (GO:0006577)4.75373165
39alpha-amino acid catabolic process (GO:1901606)4.74520488
40tyrosine metabolic process (GO:0006570)4.68857259
41drug metabolic process (GO:0017144)4.68641384
42regulation of complement activation (GO:0030449)4.62806302
43negative regulation of hemostasis (GO:1900047)4.61589610
44negative regulation of blood coagulation (GO:0030195)4.61589610
45protein activation cascade (GO:0072376)4.57433847
46reverse cholesterol transport (GO:0043691)4.57162159
47cellular ketone body metabolic process (GO:0046950)4.55586417
48* regulation of plasminogen activation (GO:0010755)4.55168409
49regulation of triglyceride catabolic process (GO:0010896)4.53991962
50regulation of cholesterol esterification (GO:0010872)4.53499242
51acute-phase response (GO:0006953)4.51378567
52negative regulation of lipase activity (GO:0060192)4.47456149
53oxidative demethylation (GO:0070989)4.47045554
54serine family amino acid metabolic process (GO:0009069)4.45498893
55protein-lipid complex remodeling (GO:0034368)4.44692418
56macromolecular complex remodeling (GO:0034367)4.44692418
57plasma lipoprotein particle remodeling (GO:0034369)4.44692418
58indolalkylamine metabolic process (GO:0006586)4.42466738
59negative regulation of cholesterol transport (GO:0032375)4.42001362
60negative regulation of sterol transport (GO:0032372)4.42001362
61glutamate metabolic process (GO:0006536)4.41729811
62cellular amino acid catabolic process (GO:0009063)4.41323563
63triglyceride homeostasis (GO:0070328)4.40866465
64acylglycerol homeostasis (GO:0055090)4.40866465
65plasma lipoprotein particle organization (GO:0071827)4.40742432
66negative regulation of protein activation cascade (GO:2000258)4.40530832
67glycine metabolic process (GO:0006544)4.39877324
68phenylpropanoid metabolic process (GO:0009698)4.38924374
69cellular modified amino acid catabolic process (GO:0042219)4.36223928
70protein-lipid complex assembly (GO:0065005)4.33944681
71coenzyme catabolic process (GO:0009109)4.32427972
72amine catabolic process (GO:0009310)4.31842504
73cellular biogenic amine catabolic process (GO:0042402)4.31842504
74drug catabolic process (GO:0042737)4.29400775
75positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.25311180
76phospholipid efflux (GO:0033700)4.24268268
77serine family amino acid biosynthetic process (GO:0009070)4.23557544
78negative regulation of coagulation (GO:0050819)4.21309771
79urate metabolic process (GO:0046415)4.20578657
80regulation of humoral immune response (GO:0002920)4.19866353
81benzene-containing compound metabolic process (GO:0042537)4.19854117
82cellular glucuronidation (GO:0052695)4.19139868
83drug transmembrane transport (GO:0006855)4.17247616
84imidazole-containing compound metabolic process (GO:0052803)4.17211448
85ethanol metabolic process (GO:0006067)4.14972526
86complement activation, classical pathway (GO:0006958)4.14724465
87bile acid and bile salt transport (GO:0015721)4.13713633
88protein-lipid complex subunit organization (GO:0071825)4.12813061
89regulation of apoptotic cell clearance (GO:2000425)4.11143473
90plasma lipoprotein particle clearance (GO:0034381)4.10388478
91negative regulation of wound healing (GO:0061045)4.09010274
92positive regulation of hemostasis (GO:1900048)4.08465616
93positive regulation of blood coagulation (GO:0030194)4.08465616
94ethanol oxidation (GO:0006069)4.06160965
95aldehyde catabolic process (GO:0046185)4.03611912
96complement activation (GO:0006956)4.02010735
97short-chain fatty acid metabolic process (GO:0046459)4.00135041
98dicarboxylic acid biosynthetic process (GO:0043650)3.99494268
99ketone body metabolic process (GO:1902224)3.93991995
100arginine metabolic process (GO:0006525)3.91239345
101aspartate family amino acid catabolic process (GO:0009068)3.90565603
102cholesterol efflux (GO:0033344)3.88820251
103carboxylic acid catabolic process (GO:0046395)3.87016582
104organic acid catabolic process (GO:0016054)3.87016582
105acetyl-CoA metabolic process (GO:0006084)3.83556154
106exogenous drug catabolic process (GO:0042738)3.81347544
107fibrinolysis (GO:0042730)3.79663396
108positive regulation of fatty acid biosynthetic process (GO:0045723)3.78592649
109glucuronate metabolic process (GO:0019585)3.78548835
110uronic acid metabolic process (GO:0006063)3.78548835
111positive regulation of coagulation (GO:0050820)3.76903357
112proline metabolic process (GO:0006560)3.74908918
113regulation of cholesterol homeostasis (GO:2000188)3.73923333
114S-adenosylmethionine metabolic process (GO:0046500)3.72345370
115plasma lipoprotein particle assembly (GO:0034377)3.72227405
1162-oxoglutarate metabolic process (GO:0006103)3.70075031
117regulation of bile acid biosynthetic process (GO:0070857)3.69996251
118cofactor catabolic process (GO:0051187)3.69087583
119opsonization (GO:0008228)3.64911578
120low-density lipoprotein particle remodeling (GO:0034374)3.64248968
121positive regulation of triglyceride lipase activity (GO:0061365)3.63641190
122positive regulation of lipoprotein lipase activity (GO:0051006)3.63641190
123positive regulation of lipid catabolic process (GO:0050996)3.61459980
124phospholipid homeostasis (GO:0055091)3.57905206
125blood coagulation, intrinsic pathway (GO:0007597)3.57747980
126monocarboxylic acid catabolic process (GO:0072329)3.55750286
127fatty acid oxidation (GO:0019395)3.54833650
128fatty acid beta-oxidation (GO:0006635)3.54169957
129response to nitrosative stress (GO:0051409)3.52144883
130lipoprotein metabolic process (GO:0042157)3.51945246
131negative regulation of complement activation (GO:0045916)3.51829270
132carnitine metabolic process (GO:0009437)3.51463250
133NAD biosynthetic process (GO:0009435)3.51411113
134pyridine nucleotide biosynthetic process (GO:0019363)3.51270086
135nicotinamide nucleotide biosynthetic process (GO:0019359)3.51270086
136acute inflammatory response (GO:0002526)3.48547626
137heme transport (GO:0015886)3.48085361
138cytolysis (GO:0019835)3.47823977
139flavonoid metabolic process (GO:0009812)3.46120119
140regulation of lipoprotein particle clearance (GO:0010984)3.43353138
141cholesterol transport (GO:0030301)3.41028810
142sterol transport (GO:0015918)3.41028810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.35426823
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18199824
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.70449912
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43550881
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18549374
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98909636
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.97434084
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.98953010
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95516867
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18950191
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14478289
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10978181
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8896613
14CLOCK_20551151_ChIP-Seq_293T_Human1.64298429
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.60359291
16* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44761836
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.43312177
18GATA1_22025678_ChIP-Seq_K562_Human1.42577313
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41800906
20HTT_18923047_ChIP-ChIP_STHdh_Human1.33183280
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30422925
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27157274
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19127026
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13481887
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08760223
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08713129
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05315810
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03178648
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00595754
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98084730
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96622738
32ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96620907
33GATA4_25053715_ChIP-Seq_YYC3_Human0.94762595
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94492084
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93727880
36IRF8_22096565_ChIP-ChIP_GC-B_Human0.90250061
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87653147
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87093422
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86912089
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85450035
41HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83844861
42ESR2_21235772_ChIP-Seq_MCF-7_Human0.82626371
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82056499
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79961922
45AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78376280
46SMC4_20622854_ChIP-Seq_HELA_Human0.77844285
47TRIM28_21343339_ChIP-Seq_HEK293_Human0.77744715
48ESR1_21235772_ChIP-Seq_MCF-7_Human0.77300756
49DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77079467
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76727673
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76420963
52ZNF263_19887448_ChIP-Seq_K562_Human0.76367348
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74925189
54RAC3_21632823_ChIP-Seq_H3396_Human0.74450532
55RARA_24833708_ChIP-Seq_LIVER_Mouse0.73780911
56POU5F1_16518401_ChIP-PET_MESCs_Mouse0.73115665
57KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72521429
58STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72388186
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72327461
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72298824
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72173874
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71917823
63CTCF_27219007_Chip-Seq_Bcells_Human0.71557258
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70186862
65LXR_22292898_ChIP-Seq_THP-1_Human0.69435004
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69214928
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.68303962
68SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67421384
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66683633
70PIAS1_25552417_ChIP-Seq_VCAP_Human0.66392425
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66158871
72NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.65302610
73* OCT4_20526341_ChIP-Seq_ESCs_Human0.65008263
74P68_20966046_ChIP-Seq_HELA_Human0.63721950
75* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63421161
76E2F1_20622854_ChIP-Seq_HELA_Human0.63078161
77CEBPB_22108803_ChIP-Seq_LS180_Human0.61512206
78RARB_24833708_ChIP-Seq_LIVER_Mouse0.61474216
79TCF4_18268006_ChIP-ChIP_LS174T_Human0.61299362
80* SOX2_21211035_ChIP-Seq_LN229_Human0.61122689
81CREB1_26743006_Chip-Seq_LNCaP_Human0.59310884
82EGR1_19032775_ChIP-ChIP_M12_Human0.59093760
83CDX2_20551321_ChIP-Seq_CACO-2_Human0.58104568
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.57163247
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56629780
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56629780
87NFIB_24661679_ChIP-Seq_LUNG_Mouse0.56468232
88AR_20517297_ChIP-Seq_VCAP_Human0.55201171
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55172092
90GATA6_25053715_ChIP-Seq_YYC3_Human0.54069597
91MYC_19915707_ChIP-ChIP_AK7_Human0.53728206
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.53341487
93SA1_27219007_Chip-Seq_Bcells_Human0.52608766
94PHF8_20622854_ChIP-Seq_HELA_Human0.51233106
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.50574204
96ESET_19884257_ChIP-Seq_ESCs_Mouse0.50061904
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.49613210
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49554107
99* FOXA1_25552417_ChIP-Seq_VCAP_Human0.49498403
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48961546
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48578336
102TAF2_19829295_ChIP-Seq_ESCs_Human0.47798126
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47299789
104GATA1_19941826_ChIP-Seq_K562_Human0.47200155
105CBP_21632823_ChIP-Seq_H3396_Human0.46849352
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46362403
107P53_21459846_ChIP-Seq_SAOS-2_Human0.46047212
108STAT1_17558387_ChIP-Seq_HELA_Human0.45526966
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.45447619
110GATA2_19941826_ChIP-Seq_K562_Human0.44889215
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44409297
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43796818
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43673034
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42602139
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41306235
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.40722109
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40354567
118CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39703865
119* RACK7_27058665_Chip-Seq_MCF-7_Human0.38491720
120* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38002367
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.37794118
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37361952
123BCOR_27268052_Chip-Seq_Bcells_Human0.36929548
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.36598263
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.36564819
126SOX2_20726797_ChIP-Seq_SW620_Human0.36285121
127ERG_20517297_ChIP-Seq_VCAP_Human0.35467715
128SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.35452016
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.35315965
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.35297715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17301614
2MP0005360_urolithiasis7.70849778
3MP0005085_abnormal_gallbladder_physiolo6.17812030
4MP0005365_abnormal_bile_salt6.01422195
5MP0008875_abnormal_xenobiotic_pharmacok5.02310234
6MP0003806_abnormal_nucleotide_metabolis4.12252995
7MP0003252_abnormal_bile_duct3.85875190
8MP0010329_abnormal_lipoprotein_level3.38109927
9MP0005332_abnormal_amino_acid3.12168966
10MP0005083_abnormal_biliary_tract3.11294066
11MP0003195_calcinosis3.11090167
12MP0009840_abnormal_foam_cell3.04897050
13MP0001666_abnormal_nutrient_absorption2.69062129
14MP0004019_abnormal_vitamin_homeostasis2.51665312
15MP0002138_abnormal_hepatobiliary_system2.36439928
16MP0003191_abnormal_cellular_cholesterol2.33859367
17MP0000609_abnormal_liver_physiology2.07941684
18MP0002118_abnormal_lipid_homeostasis2.04788265
19MP0003868_abnormal_feces_composition1.82672223
20* MP0005319_abnormal_enzyme/_coenzyme1.78800881
21MP0001764_abnormal_homeostasis1.67816390
22MP0009643_abnormal_urine_homeostasis1.62521842
23MP0005584_abnormal_enzyme/coenzyme_acti1.61830485
24MP0005451_abnormal_body_composition1.51259459
25MP0003186_abnormal_redox_activity1.42366375
26MP0000566_synostosis1.36896707
27MP0003122_maternal_imprinting1.32453264
28MP0003656_abnormal_erythrocyte_physiolo1.28809489
29MP0009697_abnormal_copulation1.27083299
30MP0005636_abnormal_mineral_homeostasis1.25290714
31MP0003011_delayed_dark_adaptation1.21536278
32MP0000598_abnormal_liver_morphology1.16904666
33MP0003705_abnormal_hypodermis_morpholog1.10932294
34MP0009764_decreased_sensitivity_to1.05291395
35MP0005647_abnormal_sex_gland1.04334581
36MP0000604_amyloidosis1.01864721
37MP0005084_abnormal_gallbladder_morpholo1.00843646
38MP0002132_abnormal_respiratory_system0.97415608
39MP0002254_reproductive_system_inflammat0.97312867
40MP0009763_increased_sensitivity_to0.94804184
41MP0001915_intracranial_hemorrhage0.94218271
42MP0006036_abnormal_mitochondrial_physio0.94180596
43MP0001756_abnormal_urination0.93956250
44MP0005220_abnormal_exocrine_pancreas0.90710794
45* MP0009642_abnormal_blood_homeostasis0.88660339
46MP0002089_abnormal_postnatal_growth/wei0.87570067
47MP0004043_abnormal_pH_regulation0.87157492
48* MP0008469_abnormal_protein_level0.86856092
49MP0005408_hypopigmentation0.85907308
50MP0003172_abnormal_lysosome_physiology0.85131203
51MP0005670_abnormal_white_adipose0.85090910
52MP0010368_abnormal_lymphatic_system0.83699574
53* MP0002876_abnormal_thyroid_physiology0.83484284
54MP0002078_abnormal_glucose_homeostasis0.77957498
55MP0002136_abnormal_kidney_physiology0.77424728
56MP0005376_homeostasis/metabolism_phenot0.76966304
57MP0009765_abnormal_xenobiotic_induced0.75110770
58MP0002909_abnormal_adrenal_gland0.73245203
59MP0005535_abnormal_body_temperature0.71256027
60MP0003123_paternal_imprinting0.68321808
61MP0002971_abnormal_brown_adipose0.67547745
62MP0001661_extended_life_span0.66875336
63MP0005167_abnormal_blood-brain_barrier0.66529750
64MP0002249_abnormal_larynx_morphology0.64972167
65MP0005334_abnormal_fat_pad0.63494383
66MP0003329_amyloid_beta_deposits0.63061450
67MP0002928_abnormal_bile_duct0.61640695
68MP0005266_abnormal_metabolism0.61317087
69MP0002282_abnormal_trachea_morphology0.60001190
70MP0006035_abnormal_mitochondrial_morpho0.59803629
71MP0009053_abnormal_anal_canal0.59115264
72MP0004130_abnormal_muscle_cell0.58341820
73MP0009780_abnormal_chondrocyte_physiolo0.57864372
74MP0001765_abnormal_ion_homeostasis0.56199858
75MP0003690_abnormal_glial_cell0.55976866
76MP0003638_abnormal_response/metabolism_0.55453335
77MP0005395_other_phenotype0.53331871
78MP0003878_abnormal_ear_physiology0.52407508
79MP0005377_hearing/vestibular/ear_phenot0.52407508
80MP0005448_abnormal_energy_balance0.49232968
81MP0000639_abnormal_adrenal_gland0.47575959
82MP0005058_abnormal_lysosome_morphology0.46878700
83MP0003183_abnormal_peptide_metabolism0.45750535
84MP0003724_increased_susceptibility_to0.45140479
85MP0005464_abnormal_platelet_physiology0.45138609
86MP0005666_abnormal_adipose_tissue0.43887347
87MP0001944_abnormal_pancreas_morphology0.43224481
88MP0005187_abnormal_penis_morphology0.43145183
89MP0003718_maternal_effect0.42598787
90MP0002168_other_aberrant_phenotype0.42201476
91MP0004782_abnormal_surfactant_physiolog0.42086787
92MP0008873_increased_physiological_sensi0.41116820
93* MP0003953_abnormal_hormone_level0.40715955
94MP0000230_abnormal_systemic_arterial0.40545054
95MP0008874_decreased_physiological_sensi0.40509679
96MP0003075_altered_response_to0.40233416
97MP0004272_abnormal_basement_membrane0.39230174
98MP0002796_impaired_skin_barrier0.39187203
99MP0008872_abnormal_physiological_respon0.39027236
100MP0005646_abnormal_pituitary_gland0.38600415
101MP0000003_abnormal_adipose_tissue0.38331711
102MP0005164_abnormal_response_to0.37929572
103MP0004883_abnormal_blood_vessel0.37917732
104MP0009672_abnormal_birth_weight0.37819352
105MP0005166_decreased_susceptibility_to0.37320692
106MP0003436_decreased_susceptibility_to0.37173870
107MP0004264_abnormal_extraembryonic_tissu0.36140835
108MP0002135_abnormal_kidney_morphology0.35086491
109MP0004858_abnormal_nervous_system0.31781434
110MP0005379_endocrine/exocrine_gland_phen0.31526443
111MP0002822_catalepsy0.31411906
112MP0002837_dystrophic_cardiac_calcinosis0.31391636
113MP0001845_abnormal_inflammatory_respons0.30996166
114MP0000538_abnormal_urinary_bladder0.30390004
115MP0005375_adipose_tissue_phenotype0.29753076
116MP0005023_abnormal_wound_healing0.29481353
117MP0009115_abnormal_fat_cell0.29302344
118MP0004147_increased_porphyrin_level0.28863151
119MP0002970_abnormal_white_adipose0.28314894
120MP0003300_gastrointestinal_ulcer0.27901606
121MP0009384_cardiac_valve_regurgitation0.27771510
122MP0003959_abnormal_lean_body0.27667190
123MP0006082_CNS_inflammation0.27442123
124MP0005248_abnormal_Harderian_gland0.27224335
125MP0000579_abnormal_nail_morphology0.27214902
126MP0001853_heart_inflammation0.27014483
127MP0000249_abnormal_blood_vessel0.26496985
128MP0005409_darkened_coat_color0.25746647

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.23590333
2Intrahepatic cholestasis (HP:0001406)6.79812226
3Deep venous thrombosis (HP:0002625)6.78417489
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.31332465
5Xanthomatosis (HP:0000991)5.95234269
6Prolonged partial thromboplastin time (HP:0003645)5.92185560
7Hypobetalipoproteinemia (HP:0003563)5.79167549
8Hyperlipoproteinemia (HP:0010980)5.11599202
9Complement deficiency (HP:0004431)4.83763567
10Hyperammonemia (HP:0001987)4.66237603
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56445271
12Ketosis (HP:0001946)4.53811625
13Hyperglycinemia (HP:0002154)4.52716788
14Joint hemorrhage (HP:0005261)4.47491796
15Hyperglycinuria (HP:0003108)4.42041104
16Hypolipoproteinemia (HP:0010981)4.35946813
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.29986456
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27797622
19Abnormality of serine family amino acid metabolism (HP:0010894)4.26908920
20Abnormality of glycine metabolism (HP:0010895)4.26908920
21Abnormality of the common coagulation pathway (HP:0010990)4.13164123
22Epidermoid cyst (HP:0200040)4.05758117
23Abnormality of methionine metabolism (HP:0010901)4.03613188
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.97152375
25Fat malabsorption (HP:0002630)3.91867618
26Hypoalphalipoproteinemia (HP:0003233)3.85457472
27Hypoglycemic coma (HP:0001325)3.82901175
28Abnormality of pyrimidine metabolism (HP:0004353)3.71079967
29Abnormality of fatty-acid metabolism (HP:0004359)3.61534930
30Gout (HP:0001997)3.60837438
31Abnormality of the intrinsic pathway (HP:0010989)3.50194732
32Abnormality of complement system (HP:0005339)3.50017767
33Nephritis (HP:0000123)3.48069381
34Ketoacidosis (HP:0001993)3.43487895
35Abnormality of nucleobase metabolism (HP:0010932)3.42270719
36Conjugated hyperbilirubinemia (HP:0002908)3.40926664
37Delayed CNS myelination (HP:0002188)3.31882206
38Abnormality of purine metabolism (HP:0004352)3.27866094
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27469015
40Hyperbilirubinemia (HP:0002904)3.24644056
41Hypercholesterolemia (HP:0003124)3.24264672
42Abnormality of serum amino acid levels (HP:0003112)3.11569417
43Steatorrhea (HP:0002570)3.00006111
44Hepatocellular carcinoma (HP:0001402)2.99361326
45Metabolic acidosis (HP:0001942)2.96017263
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82206378
47Dicarboxylic aciduria (HP:0003215)2.82206378
48Vascular calcification (HP:0004934)2.82166265
49Lethargy (HP:0001254)2.76681992
50Spontaneous abortion (HP:0005268)2.72502588
51Myocardial infarction (HP:0001658)2.69951145
52Purpura (HP:0000979)2.67964144
53Systemic lupus erythematosus (HP:0002725)2.60036032
54Generalized aminoaciduria (HP:0002909)2.59614488
55Hypochromic microcytic anemia (HP:0004840)2.58162401
56Spastic diplegia (HP:0001264)2.52208922
57Alkalosis (HP:0001948)2.49540587
58Cardiovascular calcification (HP:0011915)2.49358714
59Increased purine levels (HP:0004368)2.47566840
60Hyperuricemia (HP:0002149)2.47566840
61Skin nodule (HP:0200036)2.46780133
62Malnutrition (HP:0004395)2.46684084
63Cerebral edema (HP:0002181)2.46563041
64Proximal tubulopathy (HP:0000114)2.46404283
65Irritability (HP:0000737)2.44339256
66Neonatal onset (HP:0003623)2.43871851
67Hypoglycemic seizures (HP:0002173)2.37525772
68Enlarged kidneys (HP:0000105)2.34063155
69Vomiting (HP:0002013)2.33505010
70Acanthocytosis (HP:0001927)2.28294323
71Late onset (HP:0003584)2.27695352
72Abnormal gallbladder morphology (HP:0012437)2.26704059
73Mitral stenosis (HP:0001718)2.25781534
74Glomerulonephritis (HP:0000099)2.23365666
75Cholelithiasis (HP:0001081)2.22809912
76Osteomalacia (HP:0002749)2.21080577
77Pancreatitis (HP:0001733)2.20704276
78Abnormality of proline metabolism (HP:0010907)2.20041401
79Hydroxyprolinuria (HP:0003080)2.20041401
80Sensorimotor neuropathy (HP:0007141)2.18860464
81Rickets (HP:0002748)2.17715499
82Esophageal varix (HP:0002040)2.16404670
83Abnormal gallbladder physiology (HP:0012438)2.15177761
84Cholecystitis (HP:0001082)2.15177761
85Glycosuria (HP:0003076)2.12970013
86Abnormality of urine glucose concentration (HP:0011016)2.12970013
87Abnormality of the Achilles tendon (HP:0005109)2.11844380
88Pulmonary embolism (HP:0002204)2.10971503
89Amyloidosis (HP:0011034)2.10667167
90Bifid scrotum (HP:0000048)2.10639722
91Brushfield spots (HP:0001088)2.09265583
92Opisthotonus (HP:0002179)2.08522617
93Recurrent gram-negative bacterial infections (HP:0005420)2.04531144
94Arthropathy (HP:0003040)2.03519570
95Thrombophlebitis (HP:0004418)2.03336210
96Abnormal enzyme/coenzyme activity (HP:0012379)2.01616840
97Menorrhagia (HP:0000132)2.01059732
98Abnormal tarsal ossification (HP:0008369)1.95914528
99Gingival bleeding (HP:0000225)1.94946123
100Hypophosphatemic rickets (HP:0004912)1.94373957
101Hyperinsulinemic hypoglycemia (HP:0000825)1.91849202
102Abnormality of transition element cation homeostasis (HP:0011030)1.91625244
103Joint swelling (HP:0001386)1.89328941
104Hemorrhage of the eye (HP:0011885)1.89286359
105Abnormality of vitamin metabolism (HP:0100508)1.88684116
106Retinal atrophy (HP:0001105)1.88579437
107Abnormality of the gallbladder (HP:0005264)1.88449072
108Abnormal cartilage morphology (HP:0002763)1.87906995
109Abnormality of iron homeostasis (HP:0011031)1.87448823
110Fair hair (HP:0002286)1.86655277
111Poikilocytosis (HP:0004447)1.83837311
112Hyperphosphaturia (HP:0003109)1.81453319
113Nephrolithiasis (HP:0000787)1.80733282
114Abnormality of carpal bone ossification (HP:0006257)1.79545721
115Facial shape deformation (HP:0011334)1.75727260
116Potter facies (HP:0002009)1.75727260
117Reduced antithrombin III activity (HP:0001976)1.74241791
118Increased serum ferritin (HP:0003281)1.69169065
119Elevated alkaline phosphatase (HP:0003155)1.67469724
120Neonatal hypoglycemia (HP:0001998)1.67074511
121Abnormality of alkaline phosphatase activity (HP:0004379)1.66666573
122Urinary glycosaminoglycan excretion (HP:0003541)1.61853324
123Mucopolysacchariduria (HP:0008155)1.61853324
124Increased serum pyruvate (HP:0003542)1.61111318
125Abnormal urine phosphate concentration (HP:0012599)1.57481412

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.62290646
2ERN14.44560160
3FGFR44.42331252
4SIK14.06684376
5AKT33.23965434
6INSRR2.74474135
7TAOK32.65996937
8ERBB42.55801655
9MST1R2.18460278
10NTRK32.16394188
11PKN22.09743177
12WNK32.01988543
13MAP2K41.99047192
14TNK21.89798745
15WNK41.88418896
16MAPK111.81857519
17TRIB31.81760058
18FLT31.77566188
19FER1.76590580
20EEF2K1.74632503
21PIK3CA1.68029530
22PIK3CG1.58327047
23TYK21.56398388
24LATS11.51238234
25EPHA21.50977895
26STK38L1.50324585
27PTK61.48144160
28ABL21.44130098
29OXSR11.40107058
30CAMK1G1.38190204
31DAPK21.36085601
32PINK11.30869966
33KDR1.26125471
34NEK91.22015927
35MAP3K71.19834722
36FGFR11.17166933
37TAOK11.17031113
38FRK1.16919354
39MAPKAPK31.16665159
40MAP2K31.16647981
41JAK21.15111140
42GRK61.14180891
43MAP3K31.12260368
44PRKAA21.05471861
45MAPK151.03545381
46FGFR20.98178290
47EPHB10.96658813
48TBK10.95193324
49ERBB20.93443742
50MAP3K20.92052333
51PDGFRA0.90664121
52MAP3K110.90148933
53MAP3K100.90109891
54MAP3K140.87997234
55PRKD30.87611073
56MET0.86320987
57TIE10.86110896
58PRKCZ0.85964319
59DYRK1B0.84408705
60MAPK40.82119374
61JAK10.80063764
62GSK3A0.78436625
63TGFBR20.78042975
64WNK10.76228473
65MAPK120.75009500
66IRAK30.73319894
67PAK30.73058435
68MARK20.72172463
69SGK30.72048132
70CDK60.70701488
71CDK120.70429489
72NLK0.68502129
73CHUK0.68170366
74PRKACG0.67969200
75PTK20.67911901
76PRKD20.67596673
77MAP2K60.67426903
78PRKAA10.67196624
79SGK10.66328075
80TYRO30.66122882
81SGK4940.65590818
82SGK2230.65590818
83SMG10.64100805
84PDK30.63959502
85PDK40.63959502
86RIPK10.61222488
87NEK10.58672079
88CSK0.58458570
89SGK20.58035793
90EPHA30.57095274
91CAMK2G0.56768893
92PDPK10.52814846
93CSNK1E0.50956453
94TAOK20.50528515
95CDC42BPA0.49987519
96CAMK1D0.44960485
97IKBKE0.44112113
98CSNK1D0.44085441
99PRKACA0.43093612
100MAPK70.42315182
101MAP2K20.42309295
102CDK70.40757032
103CSNK1G10.40138569
104PRKCI0.39525559
105GRK10.39277248
106MAP3K50.39144743
107CDK40.38478512
108PRKCQ0.38454650
109MAP2K10.38372407
110PIM20.38123546
111PRKG10.38116358
112CSF1R0.37254815
113FGFR30.36710605
114IGF1R0.35456749
115MTOR0.35406671
116EIF2AK10.35218126
117MAPK30.34676847
118RPS6KA30.31816217
119PDK20.31783627
120STK380.30593616
121RPS6KB10.29833460
122MATK0.29683940
123SRC0.29332058
124PDK10.29161155
125RET0.28629741
126LATS20.28604113
127AKT20.28554628
128DDR20.27862694
129EGFR0.27607493
130PRKCG0.26898410
131MAP3K10.26893291
132MAP3K60.26822378
133PHKG20.26681280
134CAMK40.25378819
135EPHA40.24215513
136IRAK10.24091709
137STK390.23565445
138IRAK20.23063294
139PRKCA0.22838071
140ICK0.21604932
141MAP3K130.20744840
142LRRK20.19900932

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26208617
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40972565
3Nitrogen metabolism_Homo sapiens_hsa009103.34235630
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31113726
5Arginine biosynthesis_Homo sapiens_hsa002202.95846450
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75002471
7Tryptophan metabolism_Homo sapiens_hsa003802.69236213
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60872421
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58490795
10Complement and coagulation cascades_Homo sapiens_hsa046102.53224681
11Fatty acid degradation_Homo sapiens_hsa000712.53083318
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52704847
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36492291
14Butanoate metabolism_Homo sapiens_hsa006502.32370995
15Peroxisome_Homo sapiens_hsa041462.17396658
16Propanoate metabolism_Homo sapiens_hsa006402.08401699
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05847651
18Chemical carcinogenesis_Homo sapiens_hsa052041.86365163
19Histidine metabolism_Homo sapiens_hsa003401.85596189
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83294396
21PPAR signaling pathway_Homo sapiens_hsa033201.82591893
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82551595
23Fatty acid metabolism_Homo sapiens_hsa012121.82293267
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79756381
25beta-Alanine metabolism_Homo sapiens_hsa004101.77338199
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75445971
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.70282698
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69644621
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64286618
30Selenocompound metabolism_Homo sapiens_hsa004501.61907684
31Caffeine metabolism_Homo sapiens_hsa002321.60156434
32Retinol metabolism_Homo sapiens_hsa008301.59876038
33Staphylococcus aureus infection_Homo sapiens_hsa051501.56724438
34Phenylalanine metabolism_Homo sapiens_hsa003601.52286160
35Bile secretion_Homo sapiens_hsa049761.52264890
36Pyruvate metabolism_Homo sapiens_hsa006201.50730461
37Sulfur metabolism_Homo sapiens_hsa009201.43023729
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39823507
39Tyrosine metabolism_Homo sapiens_hsa003501.35304399
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.35034819
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.34774432
42Folate biosynthesis_Homo sapiens_hsa007901.31312575
43Starch and sucrose metabolism_Homo sapiens_hsa005001.28383137
44Fatty acid elongation_Homo sapiens_hsa000621.27169426
45Biosynthesis of amino acids_Homo sapiens_hsa012301.24733130
46Carbon metabolism_Homo sapiens_hsa012001.21513044
47Fat digestion and absorption_Homo sapiens_hsa049751.14891754
48Steroid biosynthesis_Homo sapiens_hsa001001.13883522
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13220749
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12865995
51ABC transporters_Homo sapiens_hsa020101.11601132
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.06110558
53Arginine and proline metabolism_Homo sapiens_hsa003301.05958025
54Vitamin digestion and absorption_Homo sapiens_hsa049771.04580488
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99277102
56Sulfur relay system_Homo sapiens_hsa041220.98211156
57Lysine degradation_Homo sapiens_hsa003100.87579701
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84763955
59Vitamin B6 metabolism_Homo sapiens_hsa007500.81962599
60Glutathione metabolism_Homo sapiens_hsa004800.80247759
61One carbon pool by folate_Homo sapiens_hsa006700.77412715
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77052596
63Glycerolipid metabolism_Homo sapiens_hsa005610.74669893
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71285516
65Pentose phosphate pathway_Homo sapiens_hsa000300.60718483
66Metabolic pathways_Homo sapiens_hsa011000.49606455
67Fatty acid biosynthesis_Homo sapiens_hsa000610.41286322
68Fructose and mannose metabolism_Homo sapiens_hsa000510.31197853
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28953360
70Pertussis_Homo sapiens_hsa051330.26744405
71Galactose metabolism_Homo sapiens_hsa000520.25546217
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25497005
73Prion diseases_Homo sapiens_hsa050200.25398651
74Insulin resistance_Homo sapiens_hsa049310.21961574
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.20295953
76Linoleic acid metabolism_Homo sapiens_hsa005910.18082436
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17750463
78Sphingolipid metabolism_Homo sapiens_hsa006000.15882351
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.11763981
80N-Glycan biosynthesis_Homo sapiens_hsa005100.07132073
81Glucagon signaling pathway_Homo sapiens_hsa049220.06945070
82AMPK signaling pathway_Homo sapiens_hsa041520.01279824
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00817237
84Bladder cancer_Homo sapiens_hsa05219-0.2044662
85Lysosome_Homo sapiens_hsa04142-0.2021645
86Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1977704
87Other glycan degradation_Homo sapiens_hsa00511-0.1935167
88Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1778838
89Mineral absorption_Homo sapiens_hsa04978-0.1744296
90Hepatitis C_Homo sapiens_hsa05160-0.1634707
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1627088
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1603636
93Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1445933
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1368588
95Serotonergic synapse_Homo sapiens_hsa04726-0.1292466
96Regulation of autophagy_Homo sapiens_hsa04140-0.1290458
97Insulin signaling pathway_Homo sapiens_hsa04910-0.1269195
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1248303
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1238104
100Amoebiasis_Homo sapiens_hsa05146-0.1129181
101Circadian rhythm_Homo sapiens_hsa04710-0.1128227
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0970793
103African trypanosomiasis_Homo sapiens_hsa05143-0.0934174
104Renin-angiotensin system_Homo sapiens_hsa04614-0.0871467
105Protein digestion and absorption_Homo sapiens_hsa04974-0.0748628
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0721423
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0698421
108Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0582354
109Ether lipid metabolism_Homo sapiens_hsa00565-0.0577936

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