HPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.25232363
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.22911541
3L-phenylalanine catabolic process (GO:0006559)8.22911541
4regulation of fibrinolysis (GO:0051917)8.09411201
5drug catabolic process (GO:0042737)8.00933391
6negative regulation of fibrinolysis (GO:0051918)7.84087534
7epoxygenase P450 pathway (GO:0019373)7.83628639
8glyoxylate metabolic process (GO:0046487)7.79255461
9complement activation, alternative pathway (GO:0006957)7.73382752
10regulation of protein activation cascade (GO:2000257)7.55062485
11L-phenylalanine metabolic process (GO:0006558)7.52638669
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.52638669
13omega-hydroxylase P450 pathway (GO:0097267)7.48210478
14regulation of complement activation (GO:0030449)7.09991009
15ethanol oxidation (GO:0006069)6.70757088
16peptidyl-glutamic acid carboxylation (GO:0017187)6.65247896
17protein carboxylation (GO:0018214)6.65247896
18fibrinolysis (GO:0042730)6.27939379
19urea metabolic process (GO:0019627)6.22648391
20blood coagulation, intrinsic pathway (GO:0007597)6.03645106
21aromatic amino acid family catabolic process (GO:0009074)5.70301541
22nitrogen cycle metabolic process (GO:0071941)5.69755750
23drug metabolic process (GO:0017144)5.69191227
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66604783
25bile acid biosynthetic process (GO:0006699)5.64807231
26negative regulation of sterol transport (GO:0032372)5.63829792
27negative regulation of cholesterol transport (GO:0032375)5.63829792
28oxidative demethylation (GO:0070989)5.58277360
29cellular glucuronidation (GO:0052695)5.54959966
30serine family amino acid catabolic process (GO:0009071)5.47095656
31regulation of plasminogen activation (GO:0010755)5.42246507
32ethanol metabolic process (GO:0006067)5.38487091
33regulation of triglyceride catabolic process (GO:0010896)5.35077667
34urea cycle (GO:0000050)5.32625866
35uronic acid metabolic process (GO:0006063)5.27574706
36glucuronate metabolic process (GO:0019585)5.27574706
37bile acid metabolic process (GO:0008206)5.08834876
38phenylpropanoid metabolic process (GO:0009698)5.03754035
39protein activation cascade (GO:0072376)4.99254191
40imidazole-containing compound metabolic process (GO:0052803)4.91114255
41plasma lipoprotein particle remodeling (GO:0034369)4.83259155
42protein-lipid complex remodeling (GO:0034368)4.83259155
43macromolecular complex remodeling (GO:0034367)4.83259155
44tyrosine metabolic process (GO:0006570)4.78347355
45triglyceride homeostasis (GO:0070328)4.78291557
46acylglycerol homeostasis (GO:0055090)4.78291557
47negative regulation of blood coagulation (GO:0030195)4.76263313
48negative regulation of hemostasis (GO:1900047)4.76263313
49glycine metabolic process (GO:0006544)4.75375051
50high-density lipoprotein particle remodeling (GO:0034375)4.74514584
51phospholipid efflux (GO:0033700)4.71654918
52regulation of cholesterol esterification (GO:0010872)4.63016935
53complement activation (GO:0006956)4.60974223
54negative regulation of protein activation cascade (GO:2000258)4.57834948
55complement activation, classical pathway (GO:0006958)4.56468825
56S-adenosylmethionine metabolic process (GO:0046500)4.54241604
57cholesterol efflux (GO:0033344)4.53349819
58positive regulation of triglyceride lipase activity (GO:0061365)4.51092649
59positive regulation of lipoprotein lipase activity (GO:0051006)4.51092649
60acute-phase response (GO:0006953)4.49765078
61regulation of humoral immune response (GO:0002920)4.44372653
62bile acid and bile salt transport (GO:0015721)4.42931340
63glutamate metabolic process (GO:0006536)4.36625845
64negative regulation of coagulation (GO:0050819)4.32552268
65negative regulation of wound healing (GO:0061045)4.26685624
66alkaloid metabolic process (GO:0009820)4.25817923
67negative regulation of lipase activity (GO:0060192)4.19682075
68reverse cholesterol transport (GO:0043691)4.18704801
69very-low-density lipoprotein particle assembly (GO:0034379)4.17558820
70positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.15737143
71amino-acid betaine metabolic process (GO:0006577)4.12000049
72positive regulation of blood coagulation (GO:0030194)4.10795107
73positive regulation of hemostasis (GO:1900048)4.10795107
74intestinal cholesterol absorption (GO:0030299)4.04332092
75alpha-amino acid catabolic process (GO:1901606)4.01129674
76opsonization (GO:0008228)4.00238167
77cytolysis (GO:0019835)3.87658884
78serine family amino acid metabolic process (GO:0009069)3.84435968
79positive regulation of coagulation (GO:0050820)3.78046575
80plasma lipoprotein particle clearance (GO:0034381)3.76617097
81response to mercury ion (GO:0046689)3.76213618
82flavonoid metabolic process (GO:0009812)3.74987848
83negative regulation of complement activation (GO:0045916)3.73632256
84killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.73188161
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.73188161
86aromatic amino acid family metabolic process (GO:0009072)3.69991444
87arginine metabolic process (GO:0006525)3.69541938
88cellular ketone body metabolic process (GO:0046950)3.68824818
89plasma lipoprotein particle assembly (GO:0034377)3.68650418
90plasma lipoprotein particle organization (GO:0071827)3.67886505
91heme transport (GO:0015886)3.65217679
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61322870
93regulation of apoptotic cell clearance (GO:2000425)3.49626691
94positive regulation of lipid catabolic process (GO:0050996)3.46271676
95tryptophan catabolic process (GO:0006569)3.45759319
96indole-containing compound catabolic process (GO:0042436)3.45759319
97indolalkylamine catabolic process (GO:0046218)3.45759319
98protein-lipid complex subunit organization (GO:0071825)3.45565333
99cellular amino acid catabolic process (GO:0009063)3.45355489
100hormone catabolic process (GO:0042447)3.43323423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.84663417
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.54613180
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.76532146
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.57267615
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21482489
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.58681176
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51247949
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04415618
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98516861
10FOXA2_19822575_ChIP-Seq_HepG2_Human2.40400717
11* HNF4A_19822575_ChIP-Seq_HepG2_Human2.26335454
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19631995
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11086638
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3565292
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96169926
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77636815
17HTT_18923047_ChIP-ChIP_STHdh_Human1.63178754
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60973790
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.30403166
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23636668
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22483652
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21684611
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18953488
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16918758
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07519198
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01268790
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.00709176
28RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98811193
29GATA4_25053715_ChIP-Seq_YYC3_Human0.93204287
30PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91789466
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90391907
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85268567
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85233379
34ESR2_21235772_ChIP-Seq_MCF-7_Human0.83622370
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82638749
36SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78748834
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78361557
38BCAT_22108803_ChIP-Seq_LS180_Human0.77904351
39NFE2_27457419_Chip-Seq_LIVER_Mouse0.77034276
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76974951
41CDX2_20551321_ChIP-Seq_CACO-2_Human0.76703226
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75607387
43RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75051975
44SOX2_21211035_ChIP-Seq_LN229_Human0.74622908
45CEBPB_22108803_ChIP-Seq_LS180_Human0.74219956
46FOXA1_25552417_ChIP-Seq_VCAP_Human0.73561776
47KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73554436
48SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73250394
49CLOCK_20551151_ChIP-Seq_293T_Human0.73228020
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.67428230
51CBP_21632823_ChIP-Seq_H3396_Human0.67253187
52HNFA_21074721_ChIP-Seq_CACO-2_Human0.66663797
53LXR_22292898_ChIP-Seq_THP-1_Human0.66272017
54AR_20517297_ChIP-Seq_VCAP_Human0.66117880
55PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65520775
56TCF4_18268006_ChIP-ChIP_LS174T_Human0.64514444
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64478361
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63448201
59PIAS1_25552417_ChIP-Seq_VCAP_Human0.63318777
60TP53_18474530_ChIP-ChIP_U2OS_Human0.63185765
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62280749
62STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.61632724
63CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61504832
64GATA1_22025678_ChIP-Seq_K562_Human0.61223181
65GATA6_25053715_ChIP-Seq_YYC3_Human0.61166812
66EZH2_27294783_Chip-Seq_NPCs_Mouse0.60202147
67RAC3_21632823_ChIP-Seq_H3396_Human0.59847378
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59749003
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59302608
70PHF8_20622853_ChIP-Seq_HELA_Human0.58893786
71RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58387819
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58085222
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57690179
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.57546707
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.57374121
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.57007882
77P53_21459846_ChIP-Seq_SAOS-2_Human0.55960414
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.55771648
79IRF8_22096565_ChIP-ChIP_GC-B_Human0.55524784
80SMC4_20622854_ChIP-Seq_HELA_Human0.55166224
81SPI1_20517297_ChIP-Seq_HL60_Human0.54697483
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54226326
83OCT4_20526341_ChIP-Seq_ESCs_Human0.52753939
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.52503351
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.52385597
86MYC_19829295_ChIP-Seq_ESCs_Human0.52165512
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.51938190
88SOX2_20726797_ChIP-Seq_SW620_Human0.51183643
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.51143057
90CBX2_22325352_ChIP-Seq_293T-Rex_Human0.50911082
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.50855866
92CTCF_27219007_Chip-Seq_Bcells_Human0.50571092
93POU5F1_16518401_ChIP-PET_MESCs_Mouse0.50487949
94MYC_19915707_ChIP-ChIP_AK7_Human0.50323720
95NFYA_21822215_ChIP-Seq_K562_Human0.50201836
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.49854205
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.49666045
98CDX2_22108803_ChIP-Seq_LS180_Human0.49315943
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.49133829
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.48701966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.50636299
2MP0005360_urolithiasis6.28114896
3MP0005085_abnormal_gallbladder_physiolo6.26556751
4MP0005365_abnormal_bile_salt5.87864908
5MP0008875_abnormal_xenobiotic_pharmacok5.59140487
6MP0003195_calcinosis5.10343208
7MP0002138_abnormal_hepatobiliary_system4.01088371
8MP0003252_abnormal_bile_duct3.82894751
9MP0003868_abnormal_feces_composition3.35920692
10MP0001666_abnormal_nutrient_absorption3.35069655
11MP0010329_abnormal_lipoprotein_level3.07681045
12MP0009697_abnormal_copulation2.57593621
13MP0009840_abnormal_foam_cell2.57568302
14MP0003191_abnormal_cellular_cholesterol2.42504054
15MP0005332_abnormal_amino_acid2.40350847
16MP0003806_abnormal_nucleotide_metabolis2.11070133
17MP0002876_abnormal_thyroid_physiology1.97365722
18MP0000609_abnormal_liver_physiology1.84371972
19MP0002118_abnormal_lipid_homeostasis1.78394656
20MP0005670_abnormal_white_adipose1.76082094
21MP0010368_abnormal_lymphatic_system1.67410677
22MP0001764_abnormal_homeostasis1.52789708
23MP0004019_abnormal_vitamin_homeostasis1.27385959
24MP0001661_extended_life_span1.23967585
25MP0005408_hypopigmentation1.22082587
26MP0005319_abnormal_enzyme/_coenzyme1.14490489
27MP0005451_abnormal_body_composition1.13775073
28MP0002132_abnormal_respiratory_system1.06471822
29MP0000598_abnormal_liver_morphology1.03304445
30MP0003656_abnormal_erythrocyte_physiolo1.01080525
31MP0005584_abnormal_enzyme/coenzyme_acti0.99118608
32MP0009643_abnormal_urine_homeostasis0.97036283
33MP0000604_amyloidosis0.95558678
34MP0003879_abnormal_hair_cell0.93170937
35MP0001915_intracranial_hemorrhage0.92924967
36MP0009642_abnormal_blood_homeostasis0.86368974
37MP0002837_dystrophic_cardiac_calcinosis0.85321327
38MP0002971_abnormal_brown_adipose0.84972133
39MP0009763_increased_sensitivity_to0.82985282
40MP0009053_abnormal_anal_canal0.80951942
41MP0005376_homeostasis/metabolism_phenot0.80017444
42MP0003186_abnormal_redox_activity0.77943124
43MP0005636_abnormal_mineral_homeostasis0.77777271
44MP0009764_decreased_sensitivity_to0.72783009
45MP0008469_abnormal_protein_level0.71663038
46MP0005395_other_phenotype0.70873011
47MP0003690_abnormal_glial_cell0.70091929
48MP0005187_abnormal_penis_morphology0.68927063
49MP0002168_other_aberrant_phenotype0.68527906
50MP0005464_abnormal_platelet_physiology0.67977859
51MP0004130_abnormal_muscle_cell0.63785090
52MP0005535_abnormal_body_temperature0.63236473
53MP0008872_abnormal_physiological_respon0.62026442
54MP0002078_abnormal_glucose_homeostasis0.61301373
55MP0005330_cardiomyopathy0.60598357
56MP0002282_abnormal_trachea_morphology0.56774737
57MP0005266_abnormal_metabolism0.56632956
58MP0008874_decreased_physiological_sensi0.56612471
59MP0003011_delayed_dark_adaptation0.55126361
60MP0005334_abnormal_fat_pad0.52769808
61MP0005058_abnormal_lysosome_morphology0.52107468
62MP0006036_abnormal_mitochondrial_physio0.51727899
63MP0003638_abnormal_response/metabolism_0.48136210
64MP0002249_abnormal_larynx_morphology0.45933428
65MP0000249_abnormal_blood_vessel0.43612908
66MP0001986_abnormal_taste_sensitivity0.41379701
67MP0005023_abnormal_wound_healing0.40002321
68MP0003646_muscle_fatigue0.39144872
69MP0003075_altered_response_to0.37746429
70MP0000566_synostosis0.36956732
71MP0005448_abnormal_energy_balance0.36598102
72MP0004883_abnormal_blood_vessel0.34982437
73MP0005164_abnormal_response_to0.34626150
74MP0009115_abnormal_fat_cell0.34522341
75MP0002089_abnormal_postnatal_growth/wei0.33887931
76MP0003329_amyloid_beta_deposits0.33276419
77MP0002269_muscular_atrophy0.33238102
78MP0002332_abnormal_exercise_endurance0.32289422
79MP0003953_abnormal_hormone_level0.32247731
80MP0005166_decreased_susceptibility_to0.31783079
81MP0009765_abnormal_xenobiotic_induced0.30554022
82MP0000920_abnormal_myelination0.28888977
83MP0002090_abnormal_vision0.28629415
84MP0005666_abnormal_adipose_tissue0.28513502
85MP0002136_abnormal_kidney_physiology0.28393896
86MP0005385_cardiovascular_system_phenoty0.28210143
87MP0001544_abnormal_cardiovascular_syste0.28210143
88MP0009785_altered_susceptibility_to0.27791134
89MP0000751_myopathy0.26952904
90MP0000639_abnormal_adrenal_gland0.26609012
91MP0002128_abnormal_blood_circulation0.25939955
92MP0010630_abnormal_cardiac_muscle0.24644899
93MP0004782_abnormal_surfactant_physiolog0.24417332
94MP0000467_abnormal_esophagus_morphology0.23670508
95MP0004215_abnormal_myocardial_fiber0.23276636
96MP0005084_abnormal_gallbladder_morpholo0.22634855
97MP0004036_abnormal_muscle_relaxation0.22511805
98MP0004272_abnormal_basement_membrane0.22011558
99MP0006138_congestive_heart_failure0.21964452
100MP0003632_abnormal_nervous_system0.21883839

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.92189338
2Prolonged partial thromboplastin time (HP:0003645)9.00879490
3Complement deficiency (HP:0004431)9.00841502
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.68716364
5Hypobetalipoproteinemia (HP:0003563)7.94905199
6Abnormality of complement system (HP:0005339)7.20281605
7Joint hemorrhage (HP:0005261)6.51638787
8Systemic lupus erythematosus (HP:0002725)6.03115607
9Hyperlipoproteinemia (HP:0010980)5.94507157
10Conjugated hyperbilirubinemia (HP:0002908)5.78202551
11Glomerulonephritis (HP:0000099)5.24659909
12Intrahepatic cholestasis (HP:0001406)5.08797501
13Abnormality of the common coagulation pathway (HP:0010990)4.96098047
14Xanthomatosis (HP:0000991)4.90243010
15Hypolipoproteinemia (HP:0010981)4.81461191
16Spontaneous abortion (HP:0005268)4.67079617
17Abnormality of pyrimidine metabolism (HP:0004353)4.27617557
18Recurrent gram-negative bacterial infections (HP:0005420)4.16107452
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14554930
20Abnormality of the intrinsic pathway (HP:0010989)3.80428900
21Hypoalphalipoproteinemia (HP:0003233)3.73373056
22Nephritis (HP:0000123)3.65470728
23Fat malabsorption (HP:0002630)3.34574224
24Hyperglycinemia (HP:0002154)3.29628646
25Abnormality of methionine metabolism (HP:0010901)3.28798496
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28309466
27Gingival bleeding (HP:0000225)3.20382361
28Hyperammonemia (HP:0001987)3.18212441
29Hypercholesterolemia (HP:0003124)3.09158769
30Epidermoid cyst (HP:0200040)3.02966719
31Hemorrhage of the eye (HP:0011885)2.96770814
32Delayed CNS myelination (HP:0002188)2.91336545
33Generalized aminoaciduria (HP:0002909)2.89620643
34Abnormality of serine family amino acid metabolism (HP:0010894)2.83464791
35Abnormality of glycine metabolism (HP:0010895)2.83464791
36Mitral stenosis (HP:0001718)2.77325129
37Vascular calcification (HP:0004934)2.74174784
38Thrombophlebitis (HP:0004418)2.73074068
39Menorrhagia (HP:0000132)2.70627121
40Purpura (HP:0000979)2.69658778
41Steatorrhea (HP:0002570)2.55686957
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55015071
43Rickets (HP:0002748)2.54622572
44Abnormality of serum amino acid levels (HP:0003112)2.53635619
45Hyperglycinuria (HP:0003108)2.49930572
46Osteomalacia (HP:0002749)2.47826212
47Abnormality of nucleobase metabolism (HP:0010932)2.46755702
48Cardiovascular calcification (HP:0011915)2.40828059
49Fair hair (HP:0002286)2.40618582
50Pulmonary embolism (HP:0002204)2.37308920
51Neonatal hypoglycemia (HP:0001998)2.36045446
52Hyperbilirubinemia (HP:0002904)2.33814005
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.32848415
54Hepatocellular carcinoma (HP:0001402)2.29580897
55Atrioventricular block (HP:0001678)2.17030335
56Reduced antithrombin III activity (HP:0001976)2.16257789
57Metabolic acidosis (HP:0001942)2.14336518
58Abnormal gallbladder physiology (HP:0012438)2.12828937
59Cholecystitis (HP:0001082)2.12828937
60Cholelithiasis (HP:0001081)2.05956793
61Myocardial infarction (HP:0001658)2.04144832
62Arthropathy (HP:0003040)2.03582470
63Deep venous thrombosis (HP:0002625)10.2577306
64Skin nodule (HP:0200036)1.98733421
65Abnormality of the Achilles tendon (HP:0005109)1.97653489
66Abnormal gallbladder morphology (HP:0012437)1.96097921
67Poikilocytosis (HP:0004447)1.96085713
68Ketosis (HP:0001946)1.95324808
69Abnormality of urine glucose concentration (HP:0011016)1.94021937
70Glycosuria (HP:0003076)1.94021937
71Hyperphosphaturia (HP:0003109)1.91473073
72Increased serum pyruvate (HP:0003542)1.88405840
73Joint swelling (HP:0001386)1.87575154
74Abnormality of vitamin metabolism (HP:0100508)1.83736539
75Gangrene (HP:0100758)1.80310532
76Acanthocytosis (HP:0001927)1.77770623
77Elevated alkaline phosphatase (HP:0003155)1.77091089
78Hypophosphatemic rickets (HP:0004912)1.75851084
79Epistaxis (HP:0000421)1.75495277
80Irritability (HP:0000737)1.74734498
81Abnormality of iron homeostasis (HP:0011031)1.71897701
82Amyloidosis (HP:0011034)1.70449469
83Increased serum ferritin (HP:0003281)1.67579000
84Abnormal enzyme/coenzyme activity (HP:0012379)1.66189837
85Hypoglycemic coma (HP:0001325)1.64606501
86Enlarged kidneys (HP:0000105)1.63968493
87Abnormality of purine metabolism (HP:0004352)1.63860685
88Abnormality of glycolysis (HP:0004366)1.63456091
89Abnormality of alkaline phosphatase activity (HP:0004379)1.62496533
90Bifid scrotum (HP:0000048)1.61997527
91Abnormality of transition element cation homeostasis (HP:0011030)1.60244756
92Generalized hypopigmentation of hair (HP:0011358)1.59516064
93Retinal atrophy (HP:0001105)1.56201505
94Increased mean platelet volume (HP:0011877)1.55529973
95Abnormal urine phosphate concentration (HP:0012599)1.55065350
96Heart block (HP:0012722)1.52370097
97Gout (HP:0001997)1.52334315
98Reticulocytosis (HP:0001923)1.50950117
99Blue irides (HP:0000635)1.50905188
100Abnormal delivery (HP:0001787)1.50274453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.79915918
2ERN14.07413189
3PDK23.42712584
4MYLK3.09910063
5RIPK12.91923046
6LATS12.89736522
7PIK3CA2.81204373
8PIK3CG2.61585555
9TRIB32.37233099
10FGFR32.35616535
11PRKAA22.09725444
12BCKDK2.05864227
13PRKACG1.95956792
14NTRK31.89991652
15LATS21.76602750
16NEK91.73432849
17PDPK11.72548914
18SIK11.70110158
19STK38L1.60468989
20ICK1.55879396
21TYK21.51158751
22MAPK111.44557338
23EPHA31.31406404
24MUSK1.28912484
25PINK11.27725087
26MAP3K31.27127436
27PRKCG1.22977501
28NLK1.21953362
29STK381.19788247
30EPHA41.18959036
31AKT31.16771931
32TGFBR21.15139810
33PAK31.14232473
34TTN1.12644443
35MAP2K41.09879808
36PDK11.05070096
37OBSCN1.04986403
38ERBB21.02608752
39MAP3K21.02140844
40RET0.99044936
41PRKAA10.97524789
42PRKG10.97293706
43IGF1R0.94364907
44PKN20.93775727
45TAOK30.92146582
46PRKACA0.87728837
47PDGFRA0.83887344
48TNK20.83629724
49KSR20.83284638
50PRKD10.81045726
51PRPF4B0.80121324
52LMTK20.79561364
53ABL20.77969622
54JAK10.77578110
55IRAK30.77003841
56MAPKAPK30.76931650
57MAPK120.76672783
58MAP3K60.73391916
59PRKCZ0.71834271
60FER0.67422009
61SGK10.67163665
62MAP3K10.66920081
63MAP3K50.66209766
64SGK2230.65707914
65SGK4940.65707914
66WNK40.65626873
67CAMK2D0.65526454
68CSNK1D0.63980743
69RPS6KA30.62399195
70TBK10.61067359
71FGFR20.59178768
72MAPK70.59075850
73PRKACB0.58704523
74SGK20.57617052
75JAK20.55760469
76CSNK1E0.55720202
77SGK30.55436990
78NEK10.54904819
79MST1R0.52747778
80DMPK0.52287596
81PRKCB0.51468002
82PRKCE0.50960153
83DYRK1B0.50519131
84MAP3K70.46906409
85CAMK2G0.46580716
86PRKCA0.43826810
87TIE10.43651809
88CSF1R0.43376431
89MAP3K110.43221312
90FGFR10.42352628
91MAP2K20.41346337
92SRC0.40057191
93EPHB10.39904746
94CDC42BPA0.39405055
95MAPK40.38367929
96CAMK40.37641781
97ZAP700.37014556
98AKT20.36740379
99INSRR0.36308279
100GSK3A0.33379743

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.70205428
2Caffeine metabolism_Homo sapiens_hsa002324.02472685
3Complement and coagulation cascades_Homo sapiens_hsa046103.95545865
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.88854988
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.25272941
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24793826
7Retinol metabolism_Homo sapiens_hsa008303.13493524
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.82381193
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76384269
10Chemical carcinogenesis_Homo sapiens_hsa052042.69763324
11Arginine biosynthesis_Homo sapiens_hsa002202.65771738
12Phenylalanine metabolism_Homo sapiens_hsa003602.60689777
13Fatty acid degradation_Homo sapiens_hsa000712.56524606
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50408464
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.44065441
16Tyrosine metabolism_Homo sapiens_hsa003502.36240689
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.26469945
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19866877
19Histidine metabolism_Homo sapiens_hsa003402.00290009
20Butanoate metabolism_Homo sapiens_hsa006501.95009241
21Tryptophan metabolism_Homo sapiens_hsa003801.77613744
22Bile secretion_Homo sapiens_hsa049761.77478156
23Linoleic acid metabolism_Homo sapiens_hsa005911.65046060
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64044601
25PPAR signaling pathway_Homo sapiens_hsa033201.58005020
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56766576
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55595201
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50728593
29Starch and sucrose metabolism_Homo sapiens_hsa005001.43085107
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.33949873
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31584345
32Peroxisome_Homo sapiens_hsa041461.29127560
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26678896
34Staphylococcus aureus infection_Homo sapiens_hsa051501.24591953
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24261853
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.20100607
37Biosynthesis of amino acids_Homo sapiens_hsa012301.20046111
38beta-Alanine metabolism_Homo sapiens_hsa004101.18329058
39Pyruvate metabolism_Homo sapiens_hsa006201.17613338
40Prion diseases_Homo sapiens_hsa050201.12356976
41Vitamin B6 metabolism_Homo sapiens_hsa007501.05921399
42Arginine and proline metabolism_Homo sapiens_hsa003301.05188986
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01266165
44Arachidonic acid metabolism_Homo sapiens_hsa005900.98645957
45Fat digestion and absorption_Homo sapiens_hsa049750.98050291
46Propanoate metabolism_Homo sapiens_hsa006400.97342177
47Carbon metabolism_Homo sapiens_hsa012000.96426894
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94397769
49Fatty acid metabolism_Homo sapiens_hsa012120.90419964
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89381510
51One carbon pool by folate_Homo sapiens_hsa006700.84387179
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84339993
53ABC transporters_Homo sapiens_hsa020100.76018038
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.61409040
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57839747
56Sulfur metabolism_Homo sapiens_hsa009200.53672326
57Lysine degradation_Homo sapiens_hsa003100.51116537
58Sulfur relay system_Homo sapiens_hsa041220.48750803
59Metabolic pathways_Homo sapiens_hsa011000.42607514
60Fatty acid elongation_Homo sapiens_hsa000620.38193799
61Vitamin digestion and absorption_Homo sapiens_hsa049770.32189258
62Glycerolipid metabolism_Homo sapiens_hsa005610.31179757
63Fructose and mannose metabolism_Homo sapiens_hsa000510.27992112
64Pertussis_Homo sapiens_hsa051330.26640839
65Insulin resistance_Homo sapiens_hsa049310.26114044
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23778691
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20923552
68Glucagon signaling pathway_Homo sapiens_hsa049220.20834731
69Pentose phosphate pathway_Homo sapiens_hsa000300.20137090
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.18415818
71Fatty acid biosynthesis_Homo sapiens_hsa000610.17219069
72Steroid biosynthesis_Homo sapiens_hsa001000.15149889
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13596394
74Other glycan degradation_Homo sapiens_hsa005110.13117574
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.12079230
76Glutathione metabolism_Homo sapiens_hsa004800.08809206
77Galactose metabolism_Homo sapiens_hsa000520.06953845
78Mineral absorption_Homo sapiens_hsa049780.05271259
79AMPK signaling pathway_Homo sapiens_hsa041520.02382278
80Renin-angiotensin system_Homo sapiens_hsa046140.00550540
81Systemic lupus erythematosus_Homo sapiens_hsa053220.00455167
82GABAergic synapse_Homo sapiens_hsa04727-0.2517397
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2500249
84Dilated cardiomyopathy_Homo sapiens_hsa05414-0.2500224
85Type II diabetes mellitus_Homo sapiens_hsa04930-0.2340915
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1936196
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1919326
88N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1780933
89Circadian rhythm_Homo sapiens_hsa04710-0.1349567
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1209282
91Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1165681
92Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1129990
93Insulin signaling pathway_Homo sapiens_hsa04910-0.1050612
94Nitrogen metabolism_Homo sapiens_hsa00910-0.0879041
95Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0611316
96Amoebiasis_Homo sapiens_hsa05146-0.0566436
97Serotonergic synapse_Homo sapiens_hsa04726-0.0504488
98Sphingolipid metabolism_Homo sapiens_hsa00600-0.0443856
99Folate biosynthesis_Homo sapiens_hsa00790-0.0318211
100Selenocompound metabolism_Homo sapiens_hsa00450-0.0124335

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »