HPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different protein complexes termed biogenesis of lysosome-related organelles complex (BLOC)-3, BLOC4, and BLOC5. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 1. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.38778991
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.38778991
3neutrophil activation involved in immune response (GO:0002283)4.89557016
4antigen processing and presentation of endogenous antigen (GO:0019883)4.84560097
5ribosomal small subunit assembly (GO:0000028)4.83323288
6negative regulation of cell killing (GO:0031342)4.66548306
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.66548306
8positive regulation of gamma-delta T cell activation (GO:0046645)4.62362348
9DNA deamination (GO:0045006)4.48203609
10viral transcription (GO:0019083)4.41898868
11antigen processing and presentation via MHC class Ib (GO:0002475)4.39986592
12translational termination (GO:0006415)4.22351686
13positive regulation by symbiont of host defense response (GO:0052509)4.12950792
14modulation by symbiont of host defense response (GO:0052031)4.12950792
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12950792
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12950792
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.12950792
18modulation by symbiont of host immune response (GO:0052553)4.12950792
19response to peptidoglycan (GO:0032494)4.02542130
20negative regulation of phagocytosis (GO:0050765)3.97452082
21positive regulation of B cell differentiation (GO:0045579)3.89809853
22regulation of gamma-delta T cell differentiation (GO:0045586)3.87114853
23detection of bacterium (GO:0016045)3.80555415
24translational elongation (GO:0006414)3.79267639
25detection of other organism (GO:0098543)3.77941769
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76186476
27negative regulation of erythrocyte differentiation (GO:0045647)3.67442393
28macrophage activation involved in immune response (GO:0002281)3.67054283
29protein targeting to ER (GO:0045047)3.63209963
30cotranslational protein targeting to membrane (GO:0006613)3.61138894
31regulation of gamma-delta T cell activation (GO:0046643)3.60200140
32regulation of mast cell degranulation (GO:0043304)3.52894334
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45103485
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42112969
35regulation of interferon-beta biosynthetic process (GO:0045357)3.42084915
36DNA strand elongation involved in DNA replication (GO:0006271)3.38479686
37protein localization to endoplasmic reticulum (GO:0070972)3.37344260
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35270308
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32766164
40DNA unwinding involved in DNA replication (GO:0006268)3.32053296
41telomere maintenance via semi-conservative replication (GO:0032201)3.30605171
42granulocyte activation (GO:0036230)3.28737870
43regulation of B cell differentiation (GO:0045577)3.28664670
44viral life cycle (GO:0019058)3.27811945
45DNA strand elongation (GO:0022616)3.24524122
46neutrophil activation (GO:0042119)3.23441123
47translational initiation (GO:0006413)3.21541008
48myeloid cell activation involved in immune response (GO:0002275)3.20656588
49Arp2/3 complex-mediated actin nucleation (GO:0034314)3.18375276
50regulation of mast cell activation involved in immune response (GO:0033006)3.17926916
51immunoglobulin mediated immune response (GO:0016064)3.17738446
52ribosomal small subunit biogenesis (GO:0042274)3.17524618
53maturation of SSU-rRNA (GO:0030490)3.16063038
54detection of external biotic stimulus (GO:0098581)3.14511542
55regulation of B cell receptor signaling pathway (GO:0050855)3.14368058
56cellular protein complex disassembly (GO:0043624)3.14273548
57regulation of antigen processing and presentation (GO:0002577)3.08086112
58cellular response to type I interferon (GO:0071357)3.07781314
59type I interferon signaling pathway (GO:0060337)3.07781314
60regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06110079
61response to type I interferon (GO:0034340)3.05264986
62NIK/NF-kappaB signaling (GO:0038061)3.05015282
63regulation of leukocyte degranulation (GO:0043300)3.04924997
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00638192
65mannose metabolic process (GO:0006013)3.00504560
66interferon-gamma-mediated signaling pathway (GO:0060333)3.00207664
67lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97190645
68positive regulation of antigen processing and presentation (GO:0002579)2.96636097
69respiratory burst (GO:0045730)2.95549544
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93290198
71B cell receptor signaling pathway (GO:0050853)2.92365589
72protein complex disassembly (GO:0043241)2.91790870
73leukocyte aggregation (GO:0070486)2.90986033
74IMP biosynthetic process (GO:0006188)2.89972663
75DNA replication initiation (GO:0006270)2.89064983
76negative regulation of lymphocyte mediated immunity (GO:0002707)2.87865322
77cellular extravasation (GO:0045123)2.87121524
78amino sugar catabolic process (GO:0046348)2.84406134
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83511488
80folic acid-containing compound biosynthetic process (GO:0009396)2.82593883
81leukocyte degranulation (GO:0043299)2.82381001
82regulation of mast cell activation (GO:0033003)2.81392305
83B cell mediated immunity (GO:0019724)2.80498195
84response to host immune response (GO:0052572)2.80200118
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80200118
86response to muramyl dipeptide (GO:0032495)2.80175561
87negative regulation of leukocyte mediated immunity (GO:0002704)2.80018779
88positive regulation of mast cell activation (GO:0033005)2.79852263
89negative thymic T cell selection (GO:0045060)2.79264120
90telomere maintenance via recombination (GO:0000722)2.75845092
91negative regulation of granulocyte differentiation (GO:0030853)2.75146572
92negative regulation of innate immune response (GO:0045824)2.73775235
93pentose-phosphate shunt (GO:0006098)2.72852189
94negative T cell selection (GO:0043383)2.71903893
95megakaryocyte development (GO:0035855)2.71096329
96negative regulation of T cell mediated immunity (GO:0002710)2.70585894
97nuclear-transcribed mRNA catabolic process (GO:0000956)2.70298098
98regulation of interleukin-12 biosynthetic process (GO:0045075)2.70165604
99detection of biotic stimulus (GO:0009595)2.69228151
100tolerance induction (GO:0002507)2.68996409
101cellular response to zinc ion (GO:0071294)2.68322210
102macromolecular complex disassembly (GO:0032984)2.67505542
103regulation of T cell tolerance induction (GO:0002664)2.67048466
104lipopolysaccharide biosynthetic process (GO:0009103)2.66273887
105T cell apoptotic process (GO:0070231)2.66127515
106IMP metabolic process (GO:0046040)2.65976733
107regulation of platelet aggregation (GO:0090330)2.65091603
108regulation of erythrocyte differentiation (GO:0045646)2.63990109
109detection of molecule of bacterial origin (GO:0032490)2.63827159
110negative regulation of cytokine production involved in immune response (GO:0002719)2.63385376
111germinal center formation (GO:0002467)2.63149676
112pinocytosis (GO:0006907)2.62865801
113negative regulation of RNA splicing (GO:0033119)2.61371062
114positive regulation of mast cell degranulation (GO:0043306)2.61057013
115positive regulation of mast cell activation involved in immune response (GO:0033008)2.61057013
116T cell selection (GO:0045058)2.61004607
117positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58900645
118mRNA catabolic process (GO:0006402)2.58805665
119thymic T cell selection (GO:0045061)2.58648402
120defense response to protozoan (GO:0042832)2.58524337
121macrophage activation (GO:0042116)2.58046682
122cellular response to thyroid hormone stimulus (GO:0097067)2.57493510
123negative regulation of interleukin-6 production (GO:0032715)2.57002061
124positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56234693
125myeloid dendritic cell differentiation (GO:0043011)2.55550695
126T cell homeostasis (GO:0043029)2.55429983
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55420946
128modulation by virus of host process (GO:0019054)2.54355772
129ncRNA 3-end processing (GO:0043628)2.53655206
130regulation of T-helper 2 cell differentiation (GO:0045628)2.53608564
131response to host (GO:0075136)2.53258243
132response to host defenses (GO:0052200)2.53258243
133response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53258243
134positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52872974
135positive regulation of granulocyte differentiation (GO:0030854)2.52634490
136telomere maintenance via telomere lengthening (GO:0010833)2.52408180
137RNA catabolic process (GO:0006401)2.52163815
138negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51879002
139response to protozoan (GO:0001562)2.51574548
140microglial cell activation (GO:0001774)2.51121637
141oxygen transport (GO:0015671)2.50223986
142mitotic recombination (GO:0006312)2.46754459
143formation of translation preinitiation complex (GO:0001731)2.46016936
144positive thymic T cell selection (GO:0045059)2.44450709
145mature B cell differentiation involved in immune response (GO:0002313)2.44450114
146neutrophil mediated immunity (GO:0002446)2.44243662
1473-UTR-mediated mRNA stabilization (GO:0070935)2.43861308
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43114061
149negative regulation of interleukin-12 production (GO:0032695)2.42765861
150definitive hemopoiesis (GO:0060216)2.40976821
151lipopolysaccharide metabolic process (GO:0008653)2.39562015
152protein targeting to membrane (GO:0006612)2.39201415
153endosome to pigment granule transport (GO:0043485)2.38742914
154endosome to melanosome transport (GO:0035646)2.38742914
155mature B cell differentiation (GO:0002335)2.38565649
156mast cell activation (GO:0045576)2.38564967
157translesion synthesis (GO:0019985)2.38326131
158response to interferon-beta (GO:0035456)2.38008495
159ribosomal large subunit biogenesis (GO:0042273)2.37923631
160myeloid dendritic cell activation (GO:0001773)2.37814565
161protein localization to kinetochore (GO:0034501)2.36831188
162T cell migration (GO:0072678)2.36236997
163lymphocyte apoptotic process (GO:0070227)2.35296754
164necroptotic process (GO:0070266)2.34591265
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34316279
166regulation of necroptotic process (GO:0060544)2.33437929
167chaperone mediated protein folding requiring cofactor (GO:0051085)2.32032468
168actin nucleation (GO:0045010)2.30388125
169regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29766012
170mitotic nuclear envelope disassembly (GO:0007077)2.28695163
171negative regulation of glycoprotein biosynthetic process (GO:0010561)2.27784476
172regulation of protein heterodimerization activity (GO:0043497)2.27448483
173lymphocyte homeostasis (GO:0002260)2.26115306
174dosage compensation (GO:0007549)2.25505501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.93748663
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.27550871
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22968423
4MYC_22102868_ChIP-Seq_BL_Human3.21944136
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.03784027
6VDR_21846776_ChIP-Seq_THP-1_Human2.83697621
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.74846648
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67610579
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.66434434
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53170696
11SCL_19346495_ChIP-Seq_HPC-7_Human2.51439355
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20439844
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.19667550
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19228514
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18547301
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17908319
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09585761
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07542228
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05559768
20* GATA1_19941826_ChIP-Seq_K562_Human2.03268514
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.01299262
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98053811
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96092888
24SPI1_23547873_ChIP-Seq_NB4_Human1.93882279
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86365751
26MAF_26560356_Chip-Seq_TH1_Human1.85939435
27SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.85423871
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85345595
29VDR_24763502_ChIP-Seq_THP-1_Human1.84868007
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83689937
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79427461
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78508731
33TCF7_22412390_ChIP-Seq_EML_Mouse1.77047039
34UTX_26944678_Chip-Seq_JUKART_Human1.75125295
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.71275543
36MYB_26560356_Chip-Seq_TH2_Human1.71032611
37CIITA_25753668_ChIP-Seq_RAJI_Human1.70846792
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.67984994
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66695088
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66680318
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64033552
42XRN2_22483619_ChIP-Seq_HELA_Human1.63954421
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63596993
44MYB_26560356_Chip-Seq_TH1_Human1.62038250
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61274950
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59675613
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59349059
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59109226
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57762237
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57544693
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57328043
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55346530
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54125219
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53580894
55GATA1_22025678_ChIP-Seq_K562_Human1.49286849
56VDR_23849224_ChIP-Seq_CD4+_Human1.48626373
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.47949392
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47358006
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44896810
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44666348
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.44380538
62BCL6_27268052_Chip-Seq_Bcells_Human1.44365128
63FOXP3_21729870_ChIP-Seq_TREG_Human1.43629118
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.42828148
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42739256
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42506742
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41973486
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.40453175
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40392350
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38498929
71BCOR_27268052_Chip-Seq_Bcells_Human1.35487166
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.33812068
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33442259
74* GATA2_19941826_ChIP-Seq_K562_Human1.32004470
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31956892
76MAF_26560356_Chip-Seq_TH2_Human1.31946979
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30781107
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30616111
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30148872
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30016194
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29533966
82* ELF1_20517297_ChIP-Seq_JURKAT_Human1.29460470
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29174082
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29036754
85* TFEB_21752829_ChIP-Seq_HELA_Human1.28920988
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28421605
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28058534
88GABP_19822575_ChIP-Seq_HepG2_Human1.26520290
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.26473171
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26411178
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26325772
92SPI1_23127762_ChIP-Seq_K562_Human1.22541824
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22187356
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21844866
95GATA3_27048872_Chip-Seq_THYMUS_Human1.21712435
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20208393
97PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17934311
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16404177
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16319095
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16259795
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15160386
102KDM2B_26808549_Chip-Seq_DND41_Human1.14936376
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.14647547
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.14582569
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.13710553
106VDR_24787735_ChIP-Seq_THP-1_Human1.13057487
107* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13039245
108RUNX_20019798_ChIP-Seq_JUKART_Human1.11725844
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10868590
110* DCP1A_22483619_ChIP-Seq_HELA_Human1.10210287
111PU_27001747_Chip-Seq_BMDM_Mouse1.08433471
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08082167
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07998289
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07745262
115RXR_22158963_ChIP-Seq_LIVER_Mouse1.07523165
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07332632
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06471323
118LXR_22292898_ChIP-Seq_THP-1_Human1.06003570
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04698099
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02329856
121* P68_20966046_ChIP-Seq_HELA_Human1.01917105
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01584659
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01367461
124TTF2_22483619_ChIP-Seq_HELA_Human1.01238296
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00890433
126KDM5A_27292631_Chip-Seq_BREAST_Human0.97677841
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97487681
128MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96557097
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95509610
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94731865
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93991936
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.92747669
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92241730
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91759174
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91759080
136NCOR1_26117541_ChIP-Seq_K562_Human0.90249736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.65062626
2MP0001835_abnormal_antigen_presentation3.27637591
3MP0000685_abnormal_immune_system3.18228345
4MP0003763_abnormal_thymus_physiology2.52250939
5MP0003693_abnormal_embryo_hatching2.51470006
6MP0004808_abnormal_hematopoietic_stem2.49259324
7MP0001800_abnormal_humoral_immune2.46397527
8MP0005671_abnormal_response_to2.43167470
9* MP0002398_abnormal_bone_marrow2.34795985
10MP0003436_decreased_susceptibility_to2.27021883
11MP0009785_altered_susceptibility_to2.24104363
12* MP0002452_abnormal_antigen_presenting2.21827931
13MP0001873_stomach_inflammation2.21256329
14MP0001545_abnormal_hematopoietic_system2.16851442
15MP0005397_hematopoietic_system_phenotyp2.16851442
16* MP0002420_abnormal_adaptive_immunity2.16787464
17* MP0005464_abnormal_platelet_physiology2.16496332
18MP0005387_immune_system_phenotype2.14511289
19MP0001790_abnormal_immune_system2.14511289
20MP0000490_abnormal_crypts_of2.13912259
21MP0005025_abnormal_response_to2.13795063
22* MP0001819_abnormal_immune_cell2.13324121
23MP0002723_abnormal_immune_serum2.09312182
24MP0005000_abnormal_immune_tolerance2.05385810
25MP0000689_abnormal_spleen_morphology2.03893027
26MP0000716_abnormal_immune_system1.99654299
27MP0003300_gastrointestinal_ulcer1.99142753
28MP0002166_altered_tumor_susceptibility1.97603796
29MP0003111_abnormal_nucleus_morphology1.97564440
30MP0002722_abnormal_immune_system1.96166029
31MP0003303_peritoneal_inflammation1.91675155
32* MP0002419_abnormal_innate_immunity1.90477440
33MP0010352_gastrointestinal_tract_polyps1.86279133
34MP0009333_abnormal_splenocyte_physiolog1.86002203
35* MP0002429_abnormal_blood_cell1.84363938
36MP0010094_abnormal_chromosome_stability1.83860705
37MP0008260_abnormal_autophagy1.78147893
38MP0009278_abnormal_bone_marrow1.75774447
39MP0003077_abnormal_cell_cycle1.75060544
40* MP0005174_abnormal_tail_pigmentation1.74621333
41MP0000703_abnormal_thymus_morphology1.74317745
42MP0010155_abnormal_intestine_physiology1.73694877
43MP0006054_spinal_hemorrhage1.72901551
44MP0002405_respiratory_system_inflammati1.72174101
45MP0005451_abnormal_body_composition1.69915926
46MP0000465_gastrointestinal_hemorrhage1.66889057
47MP0005058_abnormal_lysosome_morphology1.62779568
48MP0002148_abnormal_hypersensitivity_rea1.62523307
49* MP0003172_abnormal_lysosome_physiology1.61754037
50MP0008007_abnormal_cellular_replicative1.59960208
51MP0000858_altered_metastatic_potential1.57645340
52MP0001853_heart_inflammation1.54378422
53MP0003866_abnormal_defecation1.47601982
54MP0009764_decreased_sensitivity_to1.47065584
55MP0002006_tumorigenesis1.46950833
56MP0004957_abnormal_blastocyst_morpholog1.46210250
57MP0003806_abnormal_nucleotide_metabolis1.45602765
58MP0003183_abnormal_peptide_metabolism1.42369289
59MP0008004_abnormal_stomach_pH1.41208912
60MP0003075_altered_response_to1.40029506
61MP0002019_abnormal_tumor_incidence1.38180703
62MP0010307_abnormal_tumor_latency1.38149538
63* MP0005075_abnormal_melanosome_morpholog1.37669597
64MP0001845_abnormal_inflammatory_respons1.37457039
65MP0000569_abnormal_digit_pigmentation1.36631154
66MP0004947_skin_inflammation1.33050938
67MP0008057_abnormal_DNA_replication1.32967601
68MP0002998_abnormal_bone_remodeling1.32068609
69MP0002138_abnormal_hepatobiliary_system1.26216057
70MP0002132_abnormal_respiratory_system1.24979990
71MP0005083_abnormal_biliary_tract1.21302303
72MP0009840_abnormal_foam_cell1.18750137
73MP0004147_increased_porphyrin_level1.15664742
74MP0000604_amyloidosis1.15159572
75MP0002933_joint_inflammation1.14105512
76MP0003828_pulmonary_edema1.14081005
77MP0003724_increased_susceptibility_to1.13520651
78MP0008058_abnormal_DNA_repair1.11941491
79MP0006082_CNS_inflammation1.10952069
80MP0003191_abnormal_cellular_cholesterol1.10842618
81MP0001533_abnormal_skeleton_physiology1.09119220
82MP0000350_abnormal_cell_proliferation1.05423723
83MP0002877_abnormal_melanocyte_morpholog1.04422242
84MP0005166_decreased_susceptibility_to1.03712956
85MP0005023_abnormal_wound_healing1.03391498
86MP0002139_abnormal_hepatobiliary_system1.02231414
87* MP0008469_abnormal_protein_level1.00902019
88MP0000313_abnormal_cell_death1.00799104
89MP0002254_reproductive_system_inflammat0.97785786
90MP0005076_abnormal_cell_differentiation0.97749861
91MP0003566_abnormal_cell_adhesion0.95591424
92MP0000477_abnormal_intestine_morphology0.95146595
93* MP0002095_abnormal_skin_pigmentation0.92715416
94* MP0000371_diluted_coat_color0.92406064
95MP0005390_skeleton_phenotype0.90025203
96MP0005310_abnormal_salivary_gland0.87003943
97MP0003448_altered_tumor_morphology0.86466904
98MP0001849_ear_inflammation0.84738259
99MP0001663_abnormal_digestive_system0.83638923
100MP0003795_abnormal_bone_structure0.81929858
101MP0003656_abnormal_erythrocyte_physiolo0.80786854
102MP0003453_abnormal_keratinocyte_physiol0.80526942
103MP0004381_abnormal_hair_follicle0.80083362
104MP0005164_abnormal_response_to0.78790718
105MP0001730_embryonic_growth_arrest0.76008439
106MP0000343_altered_response_to0.73974143
107MP0004883_abnormal_blood_vessel0.73622421
108MP0009765_abnormal_xenobiotic_induced0.72328566
109MP0008961_abnormal_basal_metabolism0.71642665
110MP0003279_aneurysm0.71174552
111MP0000358_abnormal_cell_content/0.70628465
112MP0002080_prenatal_lethality0.69606149
113MP0003186_abnormal_redox_activity0.69027337
114MP0000609_abnormal_liver_physiology0.68439714
115MP0000598_abnormal_liver_morphology0.68283492
116MP0005621_abnormal_cell_physiology0.68023037
117MP0004510_myositis0.67768835
118MP0001542_abnormal_bone_strength0.66781345
119MP0003690_abnormal_glial_cell0.66649759
120MP0008874_decreased_physiological_sensi0.66376736
121MP0005365_abnormal_bile_salt0.65833478
122* MP0002075_abnormal_coat/hair_pigmentati0.64701270
123* MP0000249_abnormal_blood_vessel0.64663807
124MP0009763_increased_sensitivity_to0.63280900
125MP0003943_abnormal_hepatobiliary_system0.62670270
126* MP0005319_abnormal_enzyme/_coenzyme0.62506775
127MP0001348_abnormal_lacrimal_gland0.60393656
128MP0003045_fibrosis0.59714145
129MP0005381_digestive/alimentary_phenotyp0.59697431
130MP0005165_increased_susceptibility_to0.59277056
131MP0005384_cellular_phenotype0.59028852
132MP0001915_intracranial_hemorrhage0.58938276
133MP0005220_abnormal_exocrine_pancreas0.58903862
134MP0001851_eye_inflammation0.57400227

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.09146145
2Abnormality of glycolipid metabolism (HP:0010969)4.39644602
3Abnormality of liposaccharide metabolism (HP:0010968)4.39644602
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.39644602
5Elevated erythrocyte sedimentation rate (HP:0003565)4.12196288
6Chronic otitis media (HP:0000389)4.03119228
7IgM deficiency (HP:0002850)3.97073823
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.78069649
9Abnormality of cells of the erythroid lineage (HP:0012130)3.64679583
10Increased cerebral lipofuscin (HP:0011813)3.56983735
11Abnormal number of erythroid precursors (HP:0012131)3.56057035
12Aplastic anemia (HP:0001915)3.52526035
13Myositis (HP:0100614)3.41851101
14Recurrent bronchitis (HP:0002837)3.31490011
15Recurrent abscess formation (HP:0002722)3.29878726
16Reticulocytopenia (HP:0001896)3.28088511
17Purpura (HP:0000979)3.23910642
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.22997299
19Eczematoid dermatitis (HP:0000976)3.18656499
20Petechiae (HP:0000967)3.17775570
21Spontaneous hematomas (HP:0007420)3.13506740
22Systemic lupus erythematosus (HP:0002725)3.10493934
23Recurrent viral infections (HP:0004429)3.01729345
24Abnormality of T cell physiology (HP:0011840)2.94981667
25Cellulitis (HP:0100658)2.94610846
26Recurrent fungal infections (HP:0002841)2.91857372
27Hypochromic microcytic anemia (HP:0004840)2.90854030
28Recurrent bacterial skin infections (HP:0005406)2.89579131
29Impaired platelet aggregation (HP:0003540)2.89502219
30Abnormal platelet function (HP:0011869)2.89502219
31Loss of speech (HP:0002371)2.86844722
32Gastrointestinal infarctions (HP:0005244)2.86233421
33Optic neuritis (HP:0100653)2.85792059
34Retrobulbar optic neuritis (HP:0100654)2.85792059
35Nasal polyposis (HP:0100582)2.83270195
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.81237539
37Increased serum ferritin (HP:0003281)2.77820847
38Panhypogammaglobulinemia (HP:0003139)2.73633991
39Urticaria (HP:0001025)2.72027777
40Periodontitis (HP:0000704)2.70605041
41Hepatosplenomegaly (HP:0001433)2.67188468
42Encephalitis (HP:0002383)2.65735481
43Microcytic anemia (HP:0001935)2.65156076
44Pulmonary infiltrates (HP:0002113)2.62679151
45* Prolonged bleeding time (HP:0003010)2.62569334
46Abnormality of iron homeostasis (HP:0011031)2.61718009
47Meningitis (HP:0001287)2.60697395
48Hypochromic anemia (HP:0001931)2.54709548
49* Epistaxis (HP:0000421)2.54662895
50Pallor (HP:0000980)2.54238718
51Abnormality of the nasal mucosa (HP:0000433)2.53581727
52Abnormality of T cells (HP:0002843)2.53050286
53Polycythemia (HP:0001901)2.51918082
54Gingivitis (HP:0000230)2.49927608
55Lymphopenia (HP:0001888)2.48945911
56Abnormality of macrophages (HP:0004311)2.48845836
57Increased IgM level (HP:0003496)2.48764724
58Mediastinal lymphadenopathy (HP:0100721)2.48661731
59* Gastrointestinal inflammation (HP:0004386)2.48466282
60Thoracic kyphosis (HP:0002942)2.47869620
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.46290879
62Pustule (HP:0200039)2.45067199
63Hyperacusis (HP:0010780)2.42153976
64Abnormality of the thoracic spine (HP:0100711)2.40956590
65Colitis (HP:0002583)2.40254326
66Chest pain (HP:0100749)2.38700852
67Progressive neurologic deterioration (HP:0002344)2.35372521
68* Gingival bleeding (HP:0000225)2.34908173
69Hemoptysis (HP:0002105)2.32912018
70Abnormality of the fingertips (HP:0001211)2.32484998
71* Inflammation of the large intestine (HP:0002037)2.32043067
72Type I transferrin isoform profile (HP:0003642)2.31562077
73Amaurosis fugax (HP:0100576)2.31286558
74Interstitial pulmonary disease (HP:0006530)2.30221284
75Lymphoma (HP:0002665)2.27659610
76Poikiloderma (HP:0001029)2.27614734
77Hypertensive crisis (HP:0100735)2.25757467
78Stomatitis (HP:0010280)2.25030271
79Recurrent skin infections (HP:0001581)2.24131130
80Abnormality of B cell number (HP:0010975)2.23295347
81B lymphocytopenia (HP:0010976)2.23295347
82Episodic fever (HP:0001954)2.22750874
83Abnormality of transition element cation homeostasis (HP:0011030)2.18732598
84Agammaglobulinemia (HP:0004432)2.18564652
85Vacuolated lymphocytes (HP:0001922)2.16066813
86Abnormal protein glycosylation (HP:0012346)2.14448283
87Abnormal glycosylation (HP:0012345)2.14448283
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14448283
89Abnormal protein N-linked glycosylation (HP:0012347)2.14448283
90Granulocytopenia (HP:0001913)2.14358995
91Vasculitis (HP:0002633)2.14075177
92Hypergammaglobulinemia (HP:0010702)2.13908112
93Keratoconjunctivitis sicca (HP:0001097)2.13855984
94Obstructive lung disease (HP:0006536)2.13095789
95Chronic obstructive pulmonary disease (HP:0006510)2.13095789
96Reduced antithrombin III activity (HP:0001976)2.11630235
97Spondylolisthesis (HP:0003302)2.10005042
98Fatigue (HP:0012378)2.06831787
99Osteomyelitis (HP:0002754)2.06249797
100Autoimmune hemolytic anemia (HP:0001890)2.05985216
101Anorexia (HP:0002039)2.05325163
102Leukocytosis (HP:0001974)2.05257577
103Myelodysplasia (HP:0002863)2.04912862
104Increased IgE level (HP:0003212)2.04302440
105Increased density of long bones (HP:0006392)2.04252991
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04221766
107Arterial thrombosis (HP:0004420)2.03989312
108Chronic sinusitis (HP:0011109)2.03960177
109Emphysema (HP:0002097)2.03813362
110Basal cell carcinoma (HP:0002671)2.03512833
111Urinary glycosaminoglycan excretion (HP:0003541)2.03393540
112Mucopolysacchariduria (HP:0008155)2.03393540
113Broad face (HP:0000283)2.00521821
114T lymphocytopenia (HP:0005403)2.00473011
115Recurrent cutaneous fungal infections (HP:0011370)1.99239067
116Chronic mucocutaneous candidiasis (HP:0002728)1.99239067
117Amyloidosis (HP:0011034)1.98546768
118Abnormality of polysaccharide metabolism (HP:0011012)1.98308686
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98308686
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98308686
121Dysostosis multiplex (HP:0000943)1.98099481
122Acute lymphatic leukemia (HP:0006721)1.97817550
123Abnormality of T cell number (HP:0011839)1.97791089
124Gastrointestinal stroma tumor (HP:0100723)1.97267703
125Acute myeloid leukemia (HP:0004808)1.96895181
126Pulmonary embolism (HP:0002204)1.96531734
127Recurrent gram-negative bacterial infections (HP:0005420)1.96267682
128Keratoconjunctivitis (HP:0001096)1.93072134
129Splenomegaly (HP:0001744)1.92441286
130Skin ulcer (HP:0200042)1.89799978
131Orchitis (HP:0100796)1.89314036
132Skin rash (HP:0000988)1.89211023
133Autoimmune thrombocytopenia (HP:0001973)1.87436959
134Abnormal hemoglobin (HP:0011902)1.87119327
135Arthralgia (HP:0002829)1.86939388
136Myocardial infarction (HP:0001658)1.84986962
137Recurrent lower respiratory tract infections (HP:0002783)1.84858934
138Microretrognathia (HP:0000308)1.84345442
139Abnormality of the prostate (HP:0008775)1.83617623
140Radial bowing (HP:0002986)1.82362055
141Macrocytic anemia (HP:0001972)1.81911853
142IgA deficiency (HP:0002720)1.79197036
143Eosinophilia (HP:0001880)1.77803793
144Abnormality of the anterior horn cell (HP:0006802)1.77435858
145Degeneration of anterior horn cells (HP:0002398)1.77435858
146Leukopenia (HP:0001882)1.76528338
147Abnormal platelet volume (HP:0011876)1.74743359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.18805009
2EEF2K3.19410002
3KIT2.71375251
4PRPF4B2.64061956
5ERN12.49004255
6SCYL22.30039083
7FLT32.29120265
8MAP3K32.25509173
9ZAP702.21990419
10TRIB32.19843662
11BTK2.15065912
12TAOK22.07902877
13PKN22.03110883
14JAK31.97965249
15TAOK11.96849439
16NME21.89520476
17BLK1.87385463
18MAP3K101.82535339
19TYK21.81214306
20LRRK21.69018551
21CSF1R1.68719848
22TBK11.59737944
23IRAK41.59328931
24NEK21.58178361
25MAP2K31.55618615
26TEC1.52941188
27TESK21.45867149
28STK101.45566215
29GRK61.42758629
30WEE11.40092116
31MAP3K11.39109222
32RPS6KA41.36812543
33SYK1.34191801
34PAK41.33159925
35MAPKAPK31.33003937
36FGR1.32321109
37RPS6KB21.32271589
38TGFBR11.29478988
39TAOK31.28897720
40TXK1.28145185
41BUB11.26668755
42EIF2AK31.25230753
43CDC71.24468830
44IRAK31.21827326
45CDK121.20138268
46PASK1.18294645
47SIK21.17132035
48PIM21.12445478
49KDR1.11374919
50IKBKE1.09065146
51LCK1.08555265
52PRKD21.07860061
53IKBKB1.04746585
54HCK1.04590404
55CDK71.04496413
56CDC42BPA1.01854058
57EIF2AK11.00475236
58CDK40.99050119
59PIM10.98460053
60TGFBR20.97062647
61MAP3K110.95243639
62PTK60.93639150
63VRK10.92308013
64ITK0.92210233
65SMG10.90953837
66ATR0.90440543
67BMX0.90229717
68BMPR20.90056938
69LYN0.87721849
70ACVR1B0.87100752
71ARAF0.86343751
72RIPK10.85368272
73MATK0.83666625
74MAP3K80.83567027
75TESK10.83541001
76FES0.81188111
77JAK10.80255620
78MAP3K130.77721429
79DYRK30.77349061
80MAP3K140.75000389
81FGFR40.72477537
82SIK10.72343064
83PDPK10.70587343
84GRK70.68508600
85DAPK10.68488421
86CDK80.67430211
87HIPK20.67296171
88CDK60.65503302
89STK160.64800025
90PDK10.64193138
91CLK10.62306519
92CHUK0.62145255
93BRD40.61841156
94PTK2B0.61507849
95MARK20.61356023
96SIK30.60253396
97RPS6KL10.59975319
98RPS6KC10.59975319
99MAPK70.59956482
100CSK0.59711312
101KSR20.59254632
102ABL20.58336427
103MAPK120.56272632
104MAP2K60.56153882
105FGFR30.54480823
106JAK20.53572388
107AURKB0.52505544
108MAP3K50.51460040
109PRKG20.51454933
110PRKCQ0.50579465
111MAP3K70.50487216
112RPS6KA60.47047248
113RIPK40.47013623
114TTN0.46904039
115BCKDK0.45919057
116RPS6KA20.44191453
117STK40.44106879
118ALK0.44003890
119MAPK110.43944186
120FYN0.43877151
121MAP3K60.43743470
122DDR20.41543859
123IRAK10.39986176
124CDK190.39765388
125IRAK20.39202318
126RAF10.39083418
127MAP3K120.39076333
128MAP2K20.38569715
129EPHB10.38286735
130BRSK20.37792207
131TNK20.37654514
132MAPKAPK20.35853754
133NLK0.35027313
134MTOR0.34339563
135MARK30.33886441
136DAPK20.32712292
137CAMKK20.30801697
138PRKD10.30566064
139MAPK40.29735544

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.78675411
2Ribosome_Homo sapiens_hsa030102.99623661
3Allograft rejection_Homo sapiens_hsa053302.86428970
4Mismatch repair_Homo sapiens_hsa034302.79571820
5Graft-versus-host disease_Homo sapiens_hsa053322.72408459
6Autoimmune thyroid disease_Homo sapiens_hsa053202.64776192
7Primary immunodeficiency_Homo sapiens_hsa053402.63863877
8Base excision repair_Homo sapiens_hsa034102.36477378
9Homologous recombination_Homo sapiens_hsa034402.12468028
10Type I diabetes mellitus_Homo sapiens_hsa049402.08658795
11Leishmaniasis_Homo sapiens_hsa051401.95528543
12B cell receptor signaling pathway_Homo sapiens_hsa046621.92010176
13Spliceosome_Homo sapiens_hsa030401.89045218
14Rheumatoid arthritis_Homo sapiens_hsa053231.86742389
15Other glycan degradation_Homo sapiens_hsa005111.78577366
16Antigen processing and presentation_Homo sapiens_hsa046121.75292728
17One carbon pool by folate_Homo sapiens_hsa006701.73026147
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.72527238
19Measles_Homo sapiens_hsa051621.66963827
20Hematopoietic cell lineage_Homo sapiens_hsa046401.64340252
21Herpes simplex infection_Homo sapiens_hsa051681.54717672
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53318866
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53058205
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.50939152
25Acute myeloid leukemia_Homo sapiens_hsa052211.50150037
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50073241
27Non-homologous end-joining_Homo sapiens_hsa034501.49881738
28N-Glycan biosynthesis_Homo sapiens_hsa005101.46390029
29Osteoclast differentiation_Homo sapiens_hsa043801.45729602
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.35620315
31Phagosome_Homo sapiens_hsa041451.35222497
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34206188
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33988016
34Cell cycle_Homo sapiens_hsa041101.33302863
35Sulfur relay system_Homo sapiens_hsa041221.31329016
36RNA transport_Homo sapiens_hsa030131.30625798
37Nucleotide excision repair_Homo sapiens_hsa034201.29950690
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29798946
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27665747
40p53 signaling pathway_Homo sapiens_hsa041151.25523690
41Shigellosis_Homo sapiens_hsa051311.25341543
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24225479
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23347047
44Pyrimidine metabolism_Homo sapiens_hsa002401.23178589
45Chronic myeloid leukemia_Homo sapiens_hsa052201.21176463
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19568484
47Apoptosis_Homo sapiens_hsa042101.18934693
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.16352060
49Legionellosis_Homo sapiens_hsa051341.16194365
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13202015
51African trypanosomiasis_Homo sapiens_hsa051431.12336248
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08504987
53Collecting duct acid secretion_Homo sapiens_hsa049661.07064410
54T cell receptor signaling pathway_Homo sapiens_hsa046601.05710059
55Hepatitis B_Homo sapiens_hsa051611.03896368
56Influenza A_Homo sapiens_hsa051641.00427129
57Epstein-Barr virus infection_Homo sapiens_hsa051690.98272227
58Fanconi anemia pathway_Homo sapiens_hsa034600.98025140
59Toxoplasmosis_Homo sapiens_hsa051450.97934720
60HTLV-I infection_Homo sapiens_hsa051660.97910717
61Viral carcinogenesis_Homo sapiens_hsa052030.97828621
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95640193
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95384987
64Pentose phosphate pathway_Homo sapiens_hsa000300.95099553
65Platelet activation_Homo sapiens_hsa046110.92302883
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92223719
67Small cell lung cancer_Homo sapiens_hsa052220.90679253
68Notch signaling pathway_Homo sapiens_hsa043300.88122621
69RNA degradation_Homo sapiens_hsa030180.85919338
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85380292
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85236636
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.83886941
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82604082
74Tuberculosis_Homo sapiens_hsa051520.80651606
75Pertussis_Homo sapiens_hsa051330.79279429
76Lysosome_Homo sapiens_hsa041420.78796569
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74596831
78Malaria_Homo sapiens_hsa051440.74326357
79TNF signaling pathway_Homo sapiens_hsa046680.74125925
80Thyroid cancer_Homo sapiens_hsa052160.74118378
81Pancreatic cancer_Homo sapiens_hsa052120.72945911
82Non-small cell lung cancer_Homo sapiens_hsa052230.71997809
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71740246
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70699702
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69812751
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68240580
87RNA polymerase_Homo sapiens_hsa030200.67627275
88Folate biosynthesis_Homo sapiens_hsa007900.67122184
89Endocytosis_Homo sapiens_hsa041440.65955346
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.64191038
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.63088191
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62677384
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.61885988
94Colorectal cancer_Homo sapiens_hsa052100.60950480
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59640754
96Chemokine signaling pathway_Homo sapiens_hsa040620.58081824
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57898408
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.57650180
99Systemic lupus erythematosus_Homo sapiens_hsa053220.57528275
100mRNA surveillance pathway_Homo sapiens_hsa030150.57437806
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57141547
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.56738870
103Caffeine metabolism_Homo sapiens_hsa002320.54783234
104Asthma_Homo sapiens_hsa053100.54618327
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53455808
106Salmonella infection_Homo sapiens_hsa051320.53248907
107Sulfur metabolism_Homo sapiens_hsa009200.52893708
108VEGF signaling pathway_Homo sapiens_hsa043700.52447475
109Proteasome_Homo sapiens_hsa030500.51461592
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49771188
111Lysine degradation_Homo sapiens_hsa003100.49275223
112Amoebiasis_Homo sapiens_hsa051460.47674490
113Bladder cancer_Homo sapiens_hsa052190.47214136
114Viral myocarditis_Homo sapiens_hsa054160.47127921
115MicroRNAs in cancer_Homo sapiens_hsa052060.46179715
116Hepatitis C_Homo sapiens_hsa051600.45642438
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44605682
118Galactose metabolism_Homo sapiens_hsa000520.43322644
119HIF-1 signaling pathway_Homo sapiens_hsa040660.42717138
120Arachidonic acid metabolism_Homo sapiens_hsa005900.42124749
121Staphylococcus aureus infection_Homo sapiens_hsa051500.41539747
122Fructose and mannose metabolism_Homo sapiens_hsa000510.41386306
123Prion diseases_Homo sapiens_hsa050200.39330160
124Prolactin signaling pathway_Homo sapiens_hsa049170.39199525
125Complement and coagulation cascades_Homo sapiens_hsa046100.36223314
126Sphingolipid metabolism_Homo sapiens_hsa006000.33193255
127Regulation of autophagy_Homo sapiens_hsa041400.31702343
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30115179
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29333952
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29149727
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.28518984
132Insulin resistance_Homo sapiens_hsa049310.27579731
133Renal cell carcinoma_Homo sapiens_hsa052110.27255747
134Vibrio cholerae infection_Homo sapiens_hsa051100.25592961
135Inositol phosphate metabolism_Homo sapiens_hsa005620.24601365

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