HPS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 5 protein. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68367467
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33314732
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.33314732
4antigen processing and presentation of endogenous antigen (GO:0019883)4.87953745
5positive regulation of gamma-delta T cell activation (GO:0046645)4.77754074
6antigen processing and presentation via MHC class Ib (GO:0002475)4.47070068
7protein localization to endosome (GO:0036010)4.12892591
8response to peptidoglycan (GO:0032494)4.04629565
9regulation of gamma-delta T cell differentiation (GO:0045586)3.88898355
10regulation of B cell receptor signaling pathway (GO:0050855)3.66293848
11regulation of gamma-delta T cell activation (GO:0046643)3.61331549
12immunoglobulin mediated immune response (GO:0016064)3.59209075
13regulation of type I interferon-mediated signaling pathway (GO:0060338)3.57921584
14JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.47473021
15Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43800154
16regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.41453711
17regulation of B cell differentiation (GO:0045577)3.37588532
18pinocytosis (GO:0006907)3.34964364
19regulation of response to interferon-gamma (GO:0060330)3.33270413
20negative regulation of interleukin-12 production (GO:0032695)3.31533588
21regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.28148331
22natural killer cell mediated cytotoxicity (GO:0042267)3.27907010
23natural killer cell mediated immunity (GO:0002228)3.27907010
24lipopolysaccharide-mediated signaling pathway (GO:0031663)3.26136582
25B cell mediated immunity (GO:0019724)3.22475269
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19555224
27positive regulation of Cdc42 GTPase activity (GO:0043089)3.13060551
28macrophage activation involved in immune response (GO:0002281)3.10440447
29natural killer cell differentiation (GO:0001779)3.08286062
30positive regulation of natural killer cell differentiation (GO:0032825)3.04245659
31modulation by symbiont of host cellular process (GO:0044068)3.03290360
32DNA deamination (GO:0045006)3.02767200
33leukocyte aggregation (GO:0070486)3.02673380
34NIK/NF-kappaB signaling (GO:0038061)3.00547207
35response to muramyl dipeptide (GO:0032495)2.97352600
36interferon-gamma-mediated signaling pathway (GO:0060333)2.96987367
37negative regulation of T cell receptor signaling pathway (GO:0050860)2.91801074
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.90963040
39barbed-end actin filament capping (GO:0051016)2.89938602
40type I interferon signaling pathway (GO:0060337)2.88896814
41cellular response to type I interferon (GO:0071357)2.88896814
42regulation of early endosome to late endosome transport (GO:2000641)2.88209787
43response to type I interferon (GO:0034340)2.87632092
44positive regulation of interferon-beta production (GO:0032728)2.87273862
45T cell apoptotic process (GO:0070231)2.87114671
46positive regulation of B cell differentiation (GO:0045579)2.85453853
47positive regulation of macrophage differentiation (GO:0045651)2.83360442
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.83206756
49epithelial cell differentiation involved in prostate gland development (GO:0060742)2.82764704
50defense response to protozoan (GO:0042832)2.81985509
51mannose metabolic process (GO:0006013)2.81277625
52response to interleukin-15 (GO:0070672)2.80820587
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80557289
54regulation of vitamin D biosynthetic process (GO:0060556)2.80505709
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79985529
56negative regulation of cell killing (GO:0031342)2.79985529
57positive regulation of interferon-alpha production (GO:0032727)2.79005104
58glycosphingolipid catabolic process (GO:0046479)2.76328286
59B cell receptor signaling pathway (GO:0050853)2.75576043
60negative regulation of viral release from host cell (GO:1902187)2.74391290
61chaperone mediated protein folding requiring cofactor (GO:0051085)2.73900574
62T cell costimulation (GO:0031295)2.73096624
63regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72978550
64negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72500129
65response to laminar fluid shear stress (GO:0034616)2.72155381
66regulation of T cell receptor signaling pathway (GO:0050856)2.71807612
67lymphocyte costimulation (GO:0031294)2.71662552
68regulation of interleukin-12 biosynthetic process (GO:0045075)2.71536761
69regulation of leukocyte degranulation (GO:0043300)2.71378684
70negative thymic T cell selection (GO:0045060)2.70189559
71apoptotic process involved in morphogenesis (GO:0060561)2.69021737
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68934930
73positive thymic T cell selection (GO:0045059)2.68247019
74amyloid precursor protein catabolic process (GO:0042987)2.67681639
75positive regulation of lamellipodium assembly (GO:0010592)2.66662231
76response to protozoan (GO:0001562)2.64290524
77endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.64134379
78regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63178286
79formation of translation preinitiation complex (GO:0001731)2.62593390
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.62120610
81myeloid dendritic cell differentiation (GO:0043011)2.62042501
82regulation of superoxide anion generation (GO:0032928)2.62008964
83detection of other organism (GO:0098543)2.61490924
84regulation of isotype switching to IgG isotypes (GO:0048302)2.61328301
85negative T cell selection (GO:0043383)2.60952711
86regulation of interferon-alpha production (GO:0032647)2.59553880
87natural killer cell activation (GO:0030101)2.57568232
88stress fiber assembly (GO:0043149)2.57516848
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55887315
90amino sugar catabolic process (GO:0046348)2.55426701
91thymic T cell selection (GO:0045061)2.55413236
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.54736296
93lymphocyte apoptotic process (GO:0070227)2.54386978
94negative regulation of erythrocyte differentiation (GO:0045647)2.53637295
95regulation of podosome assembly (GO:0071801)2.53393757
96detection of bacterium (GO:0016045)2.53061106
97mucosal-associated lymphoid tissue development (GO:0048537)2.52709930
98Peyers patch development (GO:0048541)2.52709930
99negative regulation of myeloid cell apoptotic process (GO:0033033)2.52350430
100negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52257572
101modulation by virus of host process (GO:0019054)2.51175467
102negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51122329
103oligosaccharide catabolic process (GO:0009313)2.50041074
104regulation of interferon-beta biosynthetic process (GO:0045357)2.49940054
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.49230379
106regulation of natural killer cell mediated immunity (GO:0002715)2.49230379
107glycolipid catabolic process (GO:0019377)2.48975586
108positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.48298079
109positive regulation of natural killer cell mediated immunity (GO:0002717)2.48298079
110positive regulation of mast cell activation (GO:0033005)2.47066711
111cellular response to zinc ion (GO:0071294)2.46186814
112cellular response to interleukin-15 (GO:0071350)2.46167531
113positive regulation of humoral immune response (GO:0002922)2.45811696
114ribosome assembly (GO:0042255)2.45227830
115regulation of necroptotic process (GO:0060544)2.44954560
116activation of MAPKKK activity (GO:0000185)2.44607369
117regulation of protein heterodimerization activity (GO:0043497)2.44476857
118positive regulation of isotype switching (GO:0045830)2.44199560
119pentose-phosphate shunt (GO:0006098)2.43505071
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43327202
121cellular response to interferon-beta (GO:0035458)2.42715153
122actin nucleation (GO:0045010)2.42430240
123embryonic process involved in female pregnancy (GO:0060136)2.42200771
124skin morphogenesis (GO:0043589)2.41828594
125regulation of necrotic cell death (GO:0010939)2.41553825
126cellular response to arsenic-containing substance (GO:0071243)2.40854645
127myeloid dendritic cell activation (GO:0001773)2.40734758
128regulation of mast cell degranulation (GO:0043304)2.39811312
129positive regulation of lamellipodium organization (GO:1902745)2.37481759
130regulation of chronic inflammatory response (GO:0002676)2.37342373
131regulation of T-helper 2 cell differentiation (GO:0045628)2.37301769
132leukocyte cell-cell adhesion (GO:0007159)2.36754940
133modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36374796
134positive regulation by organism of defense response of other organism involved in symbiotic interact2.36374796
135modulation by symbiont of host immune response (GO:0052553)2.36374796
136positive regulation by symbiont of host defense response (GO:0052509)2.36374796
137modulation by symbiont of host defense response (GO:0052031)2.36374796
138modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36374796
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.35912567
140response to interferon-beta (GO:0035456)2.35857225
141neutrophil activation involved in immune response (GO:0002283)2.34803967
142cellular response to thyroid hormone stimulus (GO:0097067)2.33248650
143platelet aggregation (GO:0070527)2.29179508
144proline biosynthetic process (GO:0006561)2.28963556
145COPI coating of Golgi vesicle (GO:0048205)2.28933390
146Golgi transport vesicle coating (GO:0048200)2.28933390
147lymphocyte mediated immunity (GO:0002449)2.28530339
148response to host (GO:0075136)2.28197401
149response to host defenses (GO:0052200)2.28197401
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28197401
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27977385
152negative regulation of toll-like receptor signaling pathway (GO:0034122)2.27920687
153response to thyroid hormone (GO:0097066)2.27662127
154regulation of vitamin metabolic process (GO:0030656)2.26917605
155detection of external biotic stimulus (GO:0098581)2.26900506
156T cell migration (GO:0072678)2.26785893
157low-density lipoprotein particle clearance (GO:0034383)2.24583099
158regulation of T-helper 1 cell differentiation (GO:0045625)2.24403190
159positive regulation of keratinocyte differentiation (GO:0045618)2.24079522
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.23515254
161germinal center formation (GO:0002467)2.23391542
162negative regulation of necroptotic process (GO:0060546)2.23261533
163detection of molecule of bacterial origin (GO:0032490)2.23245824
164positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.23194128
165activation of Rac GTPase activity (GO:0032863)2.22692333
166response to host immune response (GO:0052572)2.21335154
167response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.21335154
168maternal placenta development (GO:0001893)2.18906311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.38091930
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.35396231
3E2F7_22180533_ChIP-Seq_HELA_Human3.26774857
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.94313461
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.57844586
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42013626
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.38603608
8MYC_22102868_ChIP-Seq_BL_Human2.34910567
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33543408
10VDR_21846776_ChIP-Seq_THP-1_Human2.22981775
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21556628
12* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16604157
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12060165
14MYC_18555785_ChIP-Seq_MESCs_Mouse1.99553799
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98957806
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97488682
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95768641
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92199116
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.90889849
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83838904
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82907848
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80411233
23SPI1_23547873_ChIP-Seq_NB4_Human1.79275142
24MAF_26560356_Chip-Seq_TH1_Human1.75655462
25ZNF263_19887448_ChIP-Seq_K562_Human1.75368699
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74952467
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74834138
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74095411
29GATA1_22025678_ChIP-Seq_K562_Human1.71194814
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64473846
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63706268
32* IRF8_27001747_Chip-Seq_BMDM_Mouse1.63486837
33* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60104358
34MYB_26560356_Chip-Seq_TH2_Human1.58015595
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57506305
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.56666264
37UTX_26944678_Chip-Seq_JUKART_Human1.56003278
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55567073
39MYB_26560356_Chip-Seq_TH1_Human1.52122805
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.49511050
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49296586
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.48614535
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48225326
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48093220
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.46334633
46* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45992880
47* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45169039
48VDR_24763502_ChIP-Seq_THP-1_Human1.43729488
49XRN2_22483619_ChIP-Seq_HELA_Human1.41748847
50CIITA_25753668_ChIP-Seq_RAJI_Human1.41656690
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41603307
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40174239
53VDR_23849224_ChIP-Seq_CD4+_Human1.39667047
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38972911
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38622607
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38398036
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36978055
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36884330
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35710025
60TFEB_21752829_ChIP-Seq_HELA_Human1.33455630
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32574243
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32242496
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32177254
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31679657
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30979890
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29853317
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28962108
68ATF3_27146783_Chip-Seq_COLON_Human1.28330368
69TCF7_22412390_ChIP-Seq_EML_Mouse1.28115620
70MAF_26560356_Chip-Seq_TH2_Human1.27866871
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27735133
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.27263698
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27137493
74* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26861064
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.26729860
76GABP_19822575_ChIP-Seq_HepG2_Human1.25632047
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.25049171
78SCL_19346495_ChIP-Seq_HPC-7_Human1.24979602
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24746016
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24507441
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21909950
82KDM2B_26808549_Chip-Seq_K562_Human1.21807476
83NCOR1_26117541_ChIP-Seq_K562_Human1.21689277
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21106117
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20965271
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.20964069
87P68_20966046_ChIP-Seq_HELA_Human1.20912298
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19826367
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19750740
90* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18154448
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18003548
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16863151
93* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15458817
94* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13849144
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12849188
96FOXP3_21729870_ChIP-Seq_TREG_Human1.12406360
97* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12398393
98SPI1_23127762_ChIP-Seq_K562_Human1.11876052
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11827720
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11025108
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.11008142
102BCOR_27268052_Chip-Seq_Bcells_Human1.10005017
103* GATA3_27048872_Chip-Seq_THYMUS_Human1.09809091
104CLOCK_20551151_ChIP-Seq_293T_Human1.08573089
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08149063
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.07910018
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07546226
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07466609
109* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07025729
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06656588
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06474789
112KDM2B_26808549_Chip-Seq_DND41_Human1.05929336
113* DCP1A_22483619_ChIP-Seq_HELA_Human1.04786643
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04760846
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04093230
116* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03749689
117* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02963153
118LXR_22292898_ChIP-Seq_THP-1_Human1.02857734
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01880712
120ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01425558
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01254691
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01180568
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00176214
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99408501
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99307092
126NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99195722
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98504670
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98428569
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97966546
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97960987
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97818794
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97797037
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97792509
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97669359
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97629289
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97220322
137RACK7_27058665_Chip-Seq_MCF-7_Human0.96687486
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96674886
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96652874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.27357955
2MP0000685_abnormal_immune_system3.02511209
3MP0005671_abnormal_response_to2.74588327
4MP0009785_altered_susceptibility_to2.60119288
5MP0009840_abnormal_foam_cell2.50419859
6MP0005058_abnormal_lysosome_morphology2.47385221
7MP0003436_decreased_susceptibility_to2.44700458
8MP0009333_abnormal_splenocyte_physiolog2.39757692
9MP0005000_abnormal_immune_tolerance2.32711587
10MP0001800_abnormal_humoral_immune2.31865530
11MP0003763_abnormal_thymus_physiology2.27797247
12MP0003303_peritoneal_inflammation2.27325692
13MP0002452_abnormal_antigen_presenting2.23670464
14MP0006082_CNS_inflammation2.23290920
15MP0002723_abnormal_immune_serum2.22377011
16MP0001790_abnormal_immune_system2.21223121
17MP0005387_immune_system_phenotype2.21223121
18MP0005025_abnormal_response_to2.16743942
19MP0002396_abnormal_hematopoietic_system2.13192729
20MP0010234_abnormal_vibrissa_follicle2.11867890
21MP0001819_abnormal_immune_cell2.11739101
22MP0002420_abnormal_adaptive_immunity2.11578173
23MP0004510_myositis2.06024342
24* MP0002398_abnormal_bone_marrow2.02415351
25MP0002148_abnormal_hypersensitivity_rea2.00311404
26MP0002419_abnormal_innate_immunity1.97780207
27MP0002405_respiratory_system_inflammati1.94204033
28MP0005310_abnormal_salivary_gland1.84251456
29MP0000716_abnormal_immune_system1.83980518
30MP0004947_skin_inflammation1.82308530
31MP0002166_altered_tumor_susceptibility1.80333607
32MP0000689_abnormal_spleen_morphology1.79571555
33MP0001853_heart_inflammation1.79199890
34MP0002722_abnormal_immune_system1.76033202
35MP0003693_abnormal_embryo_hatching1.71854700
36MP0001849_ear_inflammation1.70236022
37MP0001845_abnormal_inflammatory_respons1.62960283
38MP0010155_abnormal_intestine_physiology1.62219689
39MP0000858_altered_metastatic_potential1.61262783
40* MP0005464_abnormal_platelet_physiology1.59362776
41* MP0002429_abnormal_blood_cell1.58087818
42MP0003705_abnormal_hypodermis_morpholog1.54749297
43MP0003646_muscle_fatigue1.51041633
44MP0005397_hematopoietic_system_phenotyp1.49144712
45MP0001545_abnormal_hematopoietic_system1.49144712
46MP0004185_abnormal_adipocyte_glucose1.47764250
47MP0010352_gastrointestinal_tract_polyps1.43139863
48MP0002796_impaired_skin_barrier1.42413721
49MP0003075_altered_response_to1.40049472
50MP0003172_abnormal_lysosome_physiology1.37966186
51MP0002006_tumorigenesis1.36293582
52MP0008469_abnormal_protein_level1.34940196
53MP0002877_abnormal_melanocyte_morpholog1.33260924
54MP0000465_gastrointestinal_hemorrhage1.32505623
55MP0000703_abnormal_thymus_morphology1.32425783
56MP0002998_abnormal_bone_remodeling1.30844028
57MP0001873_stomach_inflammation1.30742097
58MP0000343_altered_response_to1.30680856
59MP0000490_abnormal_crypts_of1.28822556
60MP0003077_abnormal_cell_cycle1.24834532
61MP0003566_abnormal_cell_adhesion1.24651361
62MP0003300_gastrointestinal_ulcer1.24394478
63MP0004957_abnormal_blastocyst_morpholog1.24381929
64MP0002254_reproductive_system_inflammat1.22604427
65MP0004233_abnormal_muscle_weight1.21040725
66MP0003448_altered_tumor_morphology1.20862848
67MP0010307_abnormal_tumor_latency1.18717062
68MP0004808_abnormal_hematopoietic_stem1.17473293
69MP0003111_abnormal_nucleus_morphology1.15946782
70MP0002019_abnormal_tumor_incidence1.15857406
71MP0002933_joint_inflammation1.15799118
72MP0005501_abnormal_skin_physiology1.13666622
73MP0005023_abnormal_wound_healing1.12666864
74MP0001533_abnormal_skeleton_physiology1.12279796
75MP0003656_abnormal_erythrocyte_physiolo1.10788834
76MP0004858_abnormal_nervous_system1.10006581
77MP0003828_pulmonary_edema1.09890210
78MP0003866_abnormal_defecation1.09151308
79MP0003191_abnormal_cellular_cholesterol1.08499578
80MP0003724_increased_susceptibility_to1.07248031
81MP0008438_abnormal_cutaneous_collagen1.02345398
82MP0001216_abnormal_epidermal_layer1.02324720
83MP0003806_abnormal_nucleotide_metabolis1.01009330
84MP0009278_abnormal_bone_marrow0.98969039
85MP0005257_abnormal_intraocular_pressure0.98775151
86MP0005076_abnormal_cell_differentiation0.97999843
87MP0006054_spinal_hemorrhage0.97309048
88MP0003329_amyloid_beta_deposits0.95496305
89MP0001730_embryonic_growth_arrest0.94170416
90MP0005623_abnormal_meninges_morphology0.92649813
91MP0002060_abnormal_skin_morphology0.91570453
92MP0008007_abnormal_cellular_replicative0.90173480
93MP0005083_abnormal_biliary_tract0.89310901
94MP0003221_abnormal_cardiomyocyte_apopto0.88527083
95MP0005666_abnormal_adipose_tissue0.88014804
96MP0000609_abnormal_liver_physiology0.87593404
97MP0005166_decreased_susceptibility_to0.87338786
98MP0001348_abnormal_lacrimal_gland0.87237672
99MP0003279_aneurysm0.87091569
100MP0000767_abnormal_smooth_muscle0.85523576
101MP0009931_abnormal_skin_appearance0.83387410
102MP0001661_extended_life_span0.82250232
103MP0000604_amyloidosis0.82048186
104MP0000358_abnormal_cell_content/0.81981465
105MP0005390_skeleton_phenotype0.81098993
106MP0003718_maternal_effect0.80278470
107MP0000598_abnormal_liver_morphology0.79957679
108MP0009764_decreased_sensitivity_to0.79502720
109MP0005375_adipose_tissue_phenotype0.78809918
110MP0000313_abnormal_cell_death0.78521377
111MP0009763_increased_sensitivity_to0.78326239
112MP0000733_abnormal_muscle_development0.76424768
113MP0002138_abnormal_hepatobiliary_system0.75655597
114MP0003795_abnormal_bone_structure0.74732823
115MP0002139_abnormal_hepatobiliary_system0.74503083
116MP0004264_abnormal_extraembryonic_tissu0.74038413
117MP0005165_increased_susceptibility_to0.73530160
118MP0005621_abnormal_cell_physiology0.73294196
119MP0000350_abnormal_cell_proliferation0.70603903
120MP0003091_abnormal_cell_migration0.69595475
121MP0009697_abnormal_copulation0.69271336
122MP0003453_abnormal_keratinocyte_physiol0.69087607
123MP0003186_abnormal_redox_activity0.67857111
124* MP0000249_abnormal_blood_vessel0.67732586
125MP0002132_abnormal_respiratory_system0.66289175
126MP0008260_abnormal_autophagy0.65981299
127MP0005451_abnormal_body_composition0.64250726
128MP0001851_eye_inflammation0.63540877
129MP0010094_abnormal_chromosome_stability0.61778518

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.00369837
2Recurrent abscess formation (HP:0002722)3.64323501
3Eczematoid dermatitis (HP:0000976)3.54707245
4IgM deficiency (HP:0002850)3.44663735
5Nasal polyposis (HP:0100582)3.28622322
6Chronic otitis media (HP:0000389)3.28109447
7Pustule (HP:0200039)3.21103320
8Recurrent bacterial skin infections (HP:0005406)3.16086034
9Recurrent fungal infections (HP:0002841)3.15267223
10Dysostosis multiplex (HP:0000943)3.10954063
11Myositis (HP:0100614)3.09816783
12Thrombocytosis (HP:0001894)3.05596081
13Abnormality of the nasal mucosa (HP:0000433)3.02178289
14Petechiae (HP:0000967)2.92525124
15Abnormality of T cells (HP:0002843)2.85373439
16Abnormality of macrophages (HP:0004311)2.82568518
17Abnormality of T cell physiology (HP:0011840)2.77868038
18Recurrent bronchitis (HP:0002837)2.77555533
19Recurrent skin infections (HP:0001581)2.67838643
20Vertebral compression fractures (HP:0002953)2.66236543
21Vacuolated lymphocytes (HP:0001922)2.65031059
22T lymphocytopenia (HP:0005403)2.63020487
23Abnormality of T cell number (HP:0011839)2.62332505
24Recurrent viral infections (HP:0004429)2.61003443
25Increased cerebral lipofuscin (HP:0011813)2.59771609
26Entropion (HP:0000621)2.59386373
27Osteolytic defects of the hand bones (HP:0009699)2.55146197
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.55146197
29Interstitial pulmonary disease (HP:0006530)2.55054230
30Chronic mucocutaneous candidiasis (HP:0002728)2.54844102
31Recurrent cutaneous fungal infections (HP:0011370)2.54844102
32Gastrointestinal inflammation (HP:0004386)2.50618370
33Thin bony cortex (HP:0002753)2.48666857
34Fatigue (HP:0012378)2.48487740
35Mucopolysacchariduria (HP:0008155)2.45852681
36Urinary glycosaminoglycan excretion (HP:0003541)2.45852681
37Hyperacusis (HP:0010780)2.45746976
38Premature rupture of membranes (HP:0001788)2.44481032
39Cellulitis (HP:0100658)2.38682778
40Protrusio acetabuli (HP:0003179)2.34642501
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.32872596
42Recurrent gram-negative bacterial infections (HP:0005420)2.32290784
43Gastrointestinal infarctions (HP:0005244)2.32247852
44Leukocytosis (HP:0001974)2.30841387
45Autoimmune thrombocytopenia (HP:0001973)2.30077552
46Reduced subcutaneous adipose tissue (HP:0003758)2.28463569
47Combined immunodeficiency (HP:0005387)2.27384871
48Orchitis (HP:0100796)2.27355598
49Achilles tendon contracture (HP:0001771)2.27031762
50Peritonitis (HP:0002586)2.25824782
51Abnormality of polysaccharide metabolism (HP:0011012)2.25402577
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25402577
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25402577
54Upper motor neuron abnormality (HP:0002127)2.23999784
55Inflammation of the large intestine (HP:0002037)2.22724899
56Ragged-red muscle fibers (HP:0003200)2.20958176
57IgG deficiency (HP:0004315)2.19432039
58Vasculitis (HP:0002633)2.19246661
59Gingivitis (HP:0000230)2.17897811
60Mediastinal lymphadenopathy (HP:0100721)2.17627807
61Chronic diarrhea (HP:0002028)2.15937721
62Abnormality of the distal phalanges of the toes (HP:0010182)2.15359355
63Distal lower limb muscle weakness (HP:0009053)2.15355452
64Axonal loss (HP:0003447)2.12843647
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.12048183
66Increased connective tissue (HP:0009025)2.11351510
67Gastrointestinal stroma tumor (HP:0100723)2.10095494
68Cervical subluxation (HP:0003308)2.09751116
69Lymphopenia (HP:0001888)2.07179058
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.07047715
71Arterial thrombosis (HP:0004420)2.06749675
72Fragile skin (HP:0001030)2.05403290
73Polygenic inheritance (HP:0010982)2.04332635
74Asymmetric septal hypertrophy (HP:0001670)2.04221756
75Severe combined immunodeficiency (HP:0004430)2.03212126
76Progressive muscle weakness (HP:0003323)2.02691969
77Chronic obstructive pulmonary disease (HP:0006510)1.99463198
78Obstructive lung disease (HP:0006536)1.99463198
79Increased density of long bones (HP:0006392)1.98405124
80Emphysema (HP:0002097)1.98177199
81Biconcave vertebral bodies (HP:0004586)1.97285462
82Myocardial infarction (HP:0001658)1.96946060
83Joint stiffness (HP:0001387)1.96932078
84Progressive neurologic deterioration (HP:0002344)1.96877259
85Increased IgE level (HP:0003212)1.96846098
86Distal lower limb amyotrophy (HP:0008944)1.96696649
87Nuclear cataract (HP:0100018)1.96513665
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96470725
89Abnormality of the Achilles tendon (HP:0005109)1.96384924
90Bone pain (HP:0002653)1.94879844
91Pulmonary infiltrates (HP:0002113)1.93606235
92Hypergammaglobulinemia (HP:0010702)1.92504207
93Increased serum ferritin (HP:0003281)1.92239060
94Basal ganglia calcification (HP:0002135)1.92181548
95Abnormality of glycolipid metabolism (HP:0010969)1.90341793
96Abnormality of liposaccharide metabolism (HP:0010968)1.90341793
97Abnormality of glycosphingolipid metabolism (HP:0004343)1.90341793
98Short nail (HP:0001799)1.88756458
99Dilatation of the ascending aorta (HP:0005111)1.88517827
100Hypertensive crisis (HP:0100735)1.88475054
101Colitis (HP:0002583)1.88414291
102Trismus (HP:0000211)1.87547773
103Increased IgM level (HP:0003496)1.86586652
104Pathologic fracture (HP:0002756)1.86309009
105Abnormality of eosinophils (HP:0001879)1.86023923
106Polycythemia (HP:0001901)1.85370745
107Amaurosis fugax (HP:0100576)1.84825054
108Cerebral aneurysm (HP:0004944)1.84818923
109Microretrognathia (HP:0000308)1.84038741
110Genu recurvatum (HP:0002816)1.83620536
111Anorexia (HP:0002039)1.83570280
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83405220
113* Epistaxis (HP:0000421)1.82889263
114Agnosia (HP:0010524)1.82434978
115Long palpebral fissure (HP:0000637)1.80843356
116Amyloidosis (HP:0011034)1.80244056
117Radial bowing (HP:0002986)1.80237907
118Abnormality of nail color (HP:0100643)1.80214960
119Loss of speech (HP:0002371)1.79573849
120Thyroiditis (HP:0100646)1.79227167
121Purpura (HP:0000979)1.77575532
122Abnormality of the thoracic spine (HP:0100711)1.76683180
123Personality changes (HP:0000751)1.75817723
124Cerebral inclusion bodies (HP:0100314)1.75814020
125Generalized amyotrophy (HP:0003700)1.75320443
126Skin ulcer (HP:0200042)1.75115672
127Aplastic anemia (HP:0001915)1.74083874
128Urticaria (HP:0001025)1.74019594
129Hepatosplenomegaly (HP:0001433)1.73655113
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73552299
131Thoracic kyphosis (HP:0002942)1.73101850
132Atrophic scars (HP:0001075)1.72776447
133Broad face (HP:0000283)1.72634948
134Blue sclerae (HP:0000592)1.72306343
135Hemoptysis (HP:0002105)1.71228640
136Systemic lupus erythematosus (HP:0002725)1.70854699
137Micronodular cirrhosis (HP:0001413)1.70711544
138IgA deficiency (HP:0002720)1.70406519
139Poor head control (HP:0002421)1.70401011
140Rough bone trabeculation (HP:0100670)1.70010143
141Ulnar bowing (HP:0003031)1.70007960
142Retrobulbar optic neuritis (HP:0100654)1.69739332
143Neuronal loss in central nervous system (HP:0002529)1.68553298
144Hyperparathyroidism (HP:0000843)1.66098440
145Flat acetabular roof (HP:0003180)1.65390853
146Abnormal ossification of hand bones (HP:0005921)1.64875396
147Increased variability in muscle fiber diameter (HP:0003557)1.63649451
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.62464737
149Meningitis (HP:0001287)1.62430548
150Abnormal trabecular bone morphology (HP:0100671)1.61743139
151Spondylolisthesis (HP:0003302)1.61459524
152Bulbar palsy (HP:0001283)1.59994661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.74499940
2IRAK33.68851669
3SMG13.54036148
4NME23.42798318
5PRPF4B3.05849708
6TRIB32.93418894
7ERN12.63972432
8EEF2K2.41952628
9SCYL22.40346311
10JAK32.39612432
11TESK22.33514296
12ZAP702.30171809
13TYK22.29229599
14TBK12.26471852
15STK102.24429883
16PIM22.03949943
17BLK1.98340113
18BUB11.93112492
19TAOK21.89856050
20KIT1.87587292
21LRRK21.78736634
22ICK1.76109430
23RIPK11.75414525
24PKN21.73252063
25NEK21.71689703
26BTK1.66726810
27MAP3K81.61524692
28RPS6KA41.61280883
29KDR1.59156519
30JAK11.58333381
31FLT31.56184647
32EPHA21.44115843
33TTN1.34545565
34FGFR41.33146251
35WEE11.26564512
36CSF1R1.23523024
37MAP3K11.22786154
38SYK1.14506954
39MAP3K101.14362011
40EIF2AK11.13835529
41TXK1.12503775
42PIM11.12491446
43MAP2K31.12184013
44IKBKB1.10945475
45TSSK61.06325759
46BCKDK1.05846724
47IKBKE1.02846807
48LCK1.02769227
49GRK61.01521579
50HCK1.01048867
51ITK1.00211153
52MAP3K140.99946151
53IRAK20.98581845
54TESK10.98045673
55MST1R0.97963987
56EPHB10.96833298
57CSK0.94764176
58MAP3K110.92892807
59CDC42BPA0.88214411
60PAK40.87929756
61RPS6KA20.87200198
62IRAK40.86275304
63PDPK10.85122164
64JAK20.83068259
65MAP3K130.82541483
66MAP3K50.81875722
67STK30.80581226
68RPS6KL10.80480660
69RPS6KC10.80480660
70TEC0.80452244
71FGR0.79851764
72PDGFRA0.79833845
73MAPKAPK30.77794136
74PRKD20.76643277
75RAF10.76244689
76DDR20.76034883
77CLK10.75769526
78ARAF0.71937204
79LYN0.70143594
80DYRK30.69124474
81PTK60.68613947
82ALK0.67178290
83PASK0.66969279
84TAOK10.66794109
85BRAF0.66403008
86MOS0.66370061
87RPS6KB20.63192717
88RIPK40.63182987
89CDK120.62561516
90NEK10.61254893
91MAP2K20.60575755
92KSR20.60531841
93TAOK30.59975211
94BMX0.59640494
95CDK40.59334726
96PAK10.59199046
97MELK0.58876898
98TGFBR20.58871857
99BRSK20.58306312
100NEK90.58222384
101MTOR0.58167723
102CHUK0.56053132
103RPS6KA60.55533371
104ILK0.53916470
105TRPM70.53903566
106STK40.52328343
107CAMK1D0.49720823
108MAPK110.48725293
109CDK60.48551740
110PDK10.48436469
111MATK0.47383233
112PLK10.46244814
113AURKB0.45786132
114MAP3K30.45552076
115MAPK120.44099808
116EPHA30.42676869
117PRKG20.40960556
118MARK20.40821821
119AURKA0.40821716
120PAK20.40518734
121TLK10.40061947
122MAP2K60.39249136
123MAPKAPK20.39130840
124DAPK30.38359247
125SIK10.37234231
126SIK30.37159020
127HIPK20.37156431
128LMTK20.36921160
129PTK20.36820336
130LIMK10.36211623
131ABL20.35895817
132NLK0.35172824

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.55499328
2Antigen processing and presentation_Homo sapiens_hsa046122.50379870
3Leishmaniasis_Homo sapiens_hsa051402.14819716
4RNA polymerase_Homo sapiens_hsa030202.08459539
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98968984
6Vitamin B6 metabolism_Homo sapiens_hsa007501.97866963
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.88801709
8Measles_Homo sapiens_hsa051621.88033792
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86698535
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.86650505
11B cell receptor signaling pathway_Homo sapiens_hsa046621.86319666
12Sulfur relay system_Homo sapiens_hsa041221.72340148
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67594456
14Lysosome_Homo sapiens_hsa041421.66326367
15DNA replication_Homo sapiens_hsa030301.65506387
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65429729
17Shigellosis_Homo sapiens_hsa051311.62901975
18Folate biosynthesis_Homo sapiens_hsa007901.61088712
19Legionellosis_Homo sapiens_hsa051341.60398737
20Proteasome_Homo sapiens_hsa030501.59501928
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56527880
22Allograft rejection_Homo sapiens_hsa053301.54670647
23Pentose phosphate pathway_Homo sapiens_hsa000301.54591910
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53377715
25Apoptosis_Homo sapiens_hsa042101.53282290
26Osteoclast differentiation_Homo sapiens_hsa043801.47582497
27Base excision repair_Homo sapiens_hsa034101.45895367
28Systemic lupus erythematosus_Homo sapiens_hsa053221.44820503
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.42803428
30Viral myocarditis_Homo sapiens_hsa054161.40729511
31Non-small cell lung cancer_Homo sapiens_hsa052231.37197852
32Other glycan degradation_Homo sapiens_hsa005111.36792361
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35909424
34Herpes simplex infection_Homo sapiens_hsa051681.33217344
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32577235
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31553863
37Acute myeloid leukemia_Homo sapiens_hsa052211.31045339
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.30817736
39Epstein-Barr virus infection_Homo sapiens_hsa051691.29850316
40Toxoplasmosis_Homo sapiens_hsa051451.26668306
41Fructose and mannose metabolism_Homo sapiens_hsa000511.24148539
42p53 signaling pathway_Homo sapiens_hsa041151.22349650
43T cell receptor signaling pathway_Homo sapiens_hsa046601.21644545
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21241128
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20510531
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19671806
47Malaria_Homo sapiens_hsa051441.16209990
48Hematopoietic cell lineage_Homo sapiens_hsa046401.14568360
49Pyrimidine metabolism_Homo sapiens_hsa002401.14501504
50Viral carcinogenesis_Homo sapiens_hsa052031.13830466
51Chronic myeloid leukemia_Homo sapiens_hsa052201.12650795
52Graft-versus-host disease_Homo sapiens_hsa053321.08821780
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07718678
54Prion diseases_Homo sapiens_hsa050201.07413526
55Hepatitis B_Homo sapiens_hsa051611.05200057
56Tuberculosis_Homo sapiens_hsa051521.02514401
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02402760
58Mismatch repair_Homo sapiens_hsa034301.01642866
59RNA transport_Homo sapiens_hsa030131.01195687
60Notch signaling pathway_Homo sapiens_hsa043300.99191420
61Staphylococcus aureus infection_Homo sapiens_hsa051500.98778365
62Influenza A_Homo sapiens_hsa051640.96863729
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96787631
64Ribosome_Homo sapiens_hsa030100.95457367
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.95009985
66Cell cycle_Homo sapiens_hsa041100.91250544
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91197829
68Amoebiasis_Homo sapiens_hsa051460.88831704
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.88543586
70Autoimmune thyroid disease_Homo sapiens_hsa053200.87680450
71Rheumatoid arthritis_Homo sapiens_hsa053230.87618397
72Pertussis_Homo sapiens_hsa051330.86818633
73Prolactin signaling pathway_Homo sapiens_hsa049170.86714186
74Biosynthesis of amino acids_Homo sapiens_hsa012300.86585930
75Renal cell carcinoma_Homo sapiens_hsa052110.86578354
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84845586
77Endometrial cancer_Homo sapiens_hsa052130.84322644
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.83151970
79TNF signaling pathway_Homo sapiens_hsa046680.82494908
80Sulfur metabolism_Homo sapiens_hsa009200.82328262
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78096737
82Vibrio cholerae infection_Homo sapiens_hsa051100.76546647
83Spliceosome_Homo sapiens_hsa030400.75495146
84HTLV-I infection_Homo sapiens_hsa051660.74537311
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74088472
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72620908
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.71953034
88VEGF signaling pathway_Homo sapiens_hsa043700.71661897
89Chemokine signaling pathway_Homo sapiens_hsa040620.71106210
90Galactose metabolism_Homo sapiens_hsa000520.69929997
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69562990
92Nucleotide excision repair_Homo sapiens_hsa034200.69470472
93Salmonella infection_Homo sapiens_hsa051320.67742765
94Pancreatic cancer_Homo sapiens_hsa052120.66316240
95Prostate cancer_Homo sapiens_hsa052150.65993961
96N-Glycan biosynthesis_Homo sapiens_hsa005100.65942129
97Endocytosis_Homo sapiens_hsa041440.65328633
98African trypanosomiasis_Homo sapiens_hsa051430.64259682
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63484583
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63077220
101Regulation of autophagy_Homo sapiens_hsa041400.62683266
102Small cell lung cancer_Homo sapiens_hsa052220.59999351
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59625731
104Glioma_Homo sapiens_hsa052140.59411708
105Insulin signaling pathway_Homo sapiens_hsa049100.57041107
106Sphingolipid metabolism_Homo sapiens_hsa006000.56961717
107Alcoholism_Homo sapiens_hsa050340.56903635
108Asthma_Homo sapiens_hsa053100.55496691
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.55249634
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54250916
111Colorectal cancer_Homo sapiens_hsa052100.54165577
112HIF-1 signaling pathway_Homo sapiens_hsa040660.53537779
113Focal adhesion_Homo sapiens_hsa045100.53395572
114Insulin resistance_Homo sapiens_hsa049310.52848196
115ErbB signaling pathway_Homo sapiens_hsa040120.52596729
116Platelet activation_Homo sapiens_hsa046110.52164110
117mTOR signaling pathway_Homo sapiens_hsa041500.51429367
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50347388
119Hepatitis C_Homo sapiens_hsa051600.50086124
120Phagosome_Homo sapiens_hsa041450.47846404
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47589922
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.46527552
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.44493843
124Thyroid cancer_Homo sapiens_hsa052160.42565063
125Bladder cancer_Homo sapiens_hsa052190.41430938
126Selenocompound metabolism_Homo sapiens_hsa004500.40077397
127Type I diabetes mellitus_Homo sapiens_hsa049400.39718417
128Carbon metabolism_Homo sapiens_hsa012000.39296090
129Proteoglycans in cancer_Homo sapiens_hsa052050.39141329

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