HPSE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular glucuronidation (GO:0052695)5.66739800
2DNA damage response, detection of DNA damage (GO:0042769)5.57011343
3L-amino acid import (GO:0043092)5.50633804
4lateral sprouting from an epithelium (GO:0060601)5.34557648
5uronic acid metabolic process (GO:0006063)4.88371917
6glucuronate metabolic process (GO:0019585)4.88371917
7negative regulation of axon extension involved in axon guidance (GO:0048843)4.78965764
8regulation of DNA methylation (GO:0044030)4.62042931
9interleukin-6-mediated signaling pathway (GO:0070102)4.61868981
10response to nitrosative stress (GO:0051409)4.57338006
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.48849260
12negative regulation of JUN kinase activity (GO:0043508)4.43652972
13regulation of cardioblast proliferation (GO:0003264)4.42577271
14regulation of secondary heart field cardioblast proliferation (GO:0003266)4.42577271
15negative regulation of keratinocyte proliferation (GO:0010839)4.39409112
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33203497
17myoblast migration (GO:0051451)4.30098833
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21894121
19outer ear morphogenesis (GO:0042473)4.18361746
20dorsal/ventral axis specification (GO:0009950)4.14054044
21amino acid import (GO:0043090)4.13045463
22branching involved in salivary gland morphogenesis (GO:0060445)4.11761960
23negative regulation of chondrocyte differentiation (GO:0032331)4.05746675
24replicative senescence (GO:0090399)4.05217450
25sodium ion export (GO:0071436)4.03455417
26postsynaptic membrane organization (GO:0001941)4.00774514
27positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.99069524
28regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.99069524
29regulation of female gonad development (GO:2000194)3.96126251
30cGMP-mediated signaling (GO:0019934)3.94835056
31regulation of meiosis I (GO:0060631)3.91573300
32cochlea morphogenesis (GO:0090103)3.91095038
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89760760
34meiotic cell cycle (GO:0051321)3.87725449
35regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.82481765
36dopaminergic neuron differentiation (GO:0071542)3.82027706
37hyperosmotic salinity response (GO:0042538)3.81388734
38mesenchyme morphogenesis (GO:0072132)3.79213900
39positive regulation of neurological system process (GO:0031646)3.78769168
40endocardial cushion morphogenesis (GO:0003203)3.74416312
41nuclear pore complex assembly (GO:0051292)3.74278725
42mitotic sister chromatid cohesion (GO:0007064)3.70340313
43negative regulation of axon guidance (GO:1902668)3.69998132
44regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.67526576
45positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.67526576
46midgut development (GO:0007494)3.65965266
47regulation of heart morphogenesis (GO:2000826)3.65864476
48cell proliferation involved in kidney development (GO:0072111)3.62264742
49regulation of female receptivity (GO:0045924)3.60051193
50cellular potassium ion homeostasis (GO:0030007)3.59952160
51presynaptic membrane assembly (GO:0097105)3.56240988
52CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.52097570
53piRNA metabolic process (GO:0034587)3.50560455
54paraxial mesoderm development (GO:0048339)3.49572888
55negative regulation of catenin import into nucleus (GO:0035414)3.47349107
56regulation of histone H3-K9 methylation (GO:0051570)3.43173091
57phosphorelay signal transduction system (GO:0000160)3.39869026
58cell proliferation involved in metanephros development (GO:0072203)3.39306739
59glucocorticoid receptor signaling pathway (GO:0042921)3.38713787
60regulation of transmission of nerve impulse (GO:0051969)3.38054194
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.37367319
62negative regulation of fatty acid transport (GO:2000192)3.35045219
63metanephric mesenchyme development (GO:0072075)3.31326969
64regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.29110521
65nuclear pore organization (GO:0006999)3.28050013
66cellular sodium ion homeostasis (GO:0006883)3.26147817
67axon ensheathment in central nervous system (GO:0032291)3.25916715
68central nervous system myelination (GO:0022010)3.25916715
69regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.25467368
70retinal cone cell development (GO:0046549)3.25401583
71aorta morphogenesis (GO:0035909)3.23833362
72oocyte development (GO:0048599)3.23606360
73neurotransmitter-gated ion channel clustering (GO:0072578)3.21295758
74bone remodeling (GO:0046849)3.19342199
75positive regulation of meiosis (GO:0045836)3.19090403
76histone H3-K9 demethylation (GO:0033169)3.16969263
77synapsis (GO:0007129)3.16627020
78synaptic vesicle docking involved in exocytosis (GO:0016081)3.16151799
79cell surface receptor signaling pathway involved in heart development (GO:0061311)3.15849609
80convergent extension (GO:0060026)3.12749223
81female gamete generation (GO:0007292)3.12402349
82relaxation of smooth muscle (GO:0044557)3.12243977
83dosage compensation (GO:0007549)3.10085301
84glycine transport (GO:0015816)3.09809720
85regulation of axon extension involved in axon guidance (GO:0048841)3.09350525
86positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.09266645
87Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.08869375
88positive regulation of mesenchymal cell proliferation (GO:0002053)3.08720638
89embryonic cranial skeleton morphogenesis (GO:0048701)3.08413787
90presynaptic membrane organization (GO:0097090)3.06389537
91synaptonemal complex assembly (GO:0007130)3.05682971
92regulation of cell fate specification (GO:0042659)3.05320073
93negative regulation of gluconeogenesis (GO:0045721)3.05318112
94cell migration involved in heart development (GO:0060973)3.03985688
95negative regulation of protein acetylation (GO:1901984)3.03584920
96locomotory exploration behavior (GO:0035641)3.03006789
97generation of neurons (GO:0048699)3.02972823
98chromosome organization involved in meiosis (GO:0070192)3.01012882
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00943752
100positive regulation of gastrulation (GO:2000543)2.99305544
101synaptonemal complex organization (GO:0070193)2.98876817
102regulation of establishment of planar polarity (GO:0090175)2.98547981
103bone trabecula formation (GO:0060346)2.97605680
104potassium ion import (GO:0010107)2.95824470
105somite rostral/caudal axis specification (GO:0032525)2.95801404
106limb development (GO:0060173)2.95419751
107appendage development (GO:0048736)2.95419751
108pyrimidine-containing compound transmembrane transport (GO:0072531)2.95145985
109gonadal mesoderm development (GO:0007506)2.94986356
110kidney mesenchyme development (GO:0072074)2.94472451
111positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.92731599
112negative regulation of cartilage development (GO:0061037)2.92716796
113mesenchymal cell development (GO:0014031)2.92438873
114positive regulation of meiotic cell cycle (GO:0051446)2.92193904
115regulation of acrosome reaction (GO:0060046)2.90961158
116positive regulation of protein import into nucleus, translocation (GO:0033160)2.88822826
117neuron cell-cell adhesion (GO:0007158)2.88391933
118cerebral cortex neuron differentiation (GO:0021895)2.87905434
119establishment of tissue polarity (GO:0007164)2.87322179
120establishment of planar polarity (GO:0001736)2.87322179
121negative regulation of DNA repair (GO:0045738)2.86617846
122male meiosis I (GO:0007141)2.85759204
123regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85419283
124negative regulation of glycogen biosynthetic process (GO:0045719)2.85388374
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.85148661
126regulation of axon regeneration (GO:0048679)2.84936747
127regulation of neuron projection regeneration (GO:0070570)2.84936747
128regulation of synaptic vesicle exocytosis (GO:2000300)2.83491253
129embryonic hindlimb morphogenesis (GO:0035116)2.83149923
130pharyngeal system development (GO:0060037)2.81613826
131appendage morphogenesis (GO:0035107)2.81073184
132limb morphogenesis (GO:0035108)2.81073184
133folic acid transport (GO:0015884)2.80995378
134female mating behavior (GO:0060180)2.80662370
135bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80353449
136negative regulation of peptidyl-lysine acetylation (GO:2000757)2.79783676
137positive regulation of dendritic spine development (GO:0060999)2.78923195
138one-carbon compound transport (GO:0019755)2.78575811
139regulation of sister chromatid cohesion (GO:0007063)2.78494119
140protein localization to synapse (GO:0035418)2.78423637
141middle ear morphogenesis (GO:0042474)2.77942798
142negative regulation of hormone biosynthetic process (GO:0032353)2.77806260
143embryonic appendage morphogenesis (GO:0035113)2.76980625
144embryonic limb morphogenesis (GO:0030326)2.76980625
145DNA methylation involved in gamete generation (GO:0043046)2.76895633
146gene silencing by RNA (GO:0031047)2.76287179
147nucleotide transmembrane transport (GO:1901679)2.75151013
148potassium ion homeostasis (GO:0055075)2.74645536
149cell communication by electrical coupling (GO:0010644)2.74573818
150palate development (GO:0060021)2.74348022
151hematopoietic stem cell proliferation (GO:0071425)2.74118761
152hindlimb morphogenesis (GO:0035137)2.73984724
153DNA damage induced protein phosphorylation (GO:0006975)2.73936207
154regulation of catenin import into nucleus (GO:0035412)2.72332863
155male meiosis (GO:0007140)2.72229479
156synaptic vesicle maturation (GO:0016188)2.70133373
157exploration behavior (GO:0035640)2.70118455
158cyclic-nucleotide-mediated signaling (GO:0019935)2.64516538
159vocalization behavior (GO:0071625)2.63694770
160synaptic vesicle exocytosis (GO:0016079)2.61456464
161negative regulation of histone methylation (GO:0031061)2.60925999
162microtubule severing (GO:0051013)2.60083045
163synaptic vesicle endocytosis (GO:0048488)2.57004997
164negative regulation of hormone metabolic process (GO:0032351)2.54083041
165regulation of steroid hormone secretion (GO:2000831)2.52020981
166regulation of synaptic vesicle transport (GO:1902803)2.51351681
167positive regulation of dendritic spine morphogenesis (GO:0061003)2.49696690
168neuronal ion channel clustering (GO:0045161)2.47614786
169regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44316991
170regulation of cell maturation (GO:1903429)2.43352783
171positive regulation of male gonad development (GO:2000020)2.41492752
172response to acidic pH (GO:0010447)2.41382592
173multicellular organism reproduction (GO:0032504)2.40214536
174spermatid nucleus differentiation (GO:0007289)2.39727438
175membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38848236
176calcium ion-dependent exocytosis (GO:0017156)2.37852316
177labyrinthine layer development (GO:0060711)2.37201906
178cilium or flagellum-dependent cell motility (GO:0001539)2.36594859
179regulation of steroid hormone biosynthetic process (GO:0090030)2.36302283
180microtubule polymerization or depolymerization (GO:0031109)2.36029030
181ephrin receptor signaling pathway (GO:0048013)2.34664215
182long-chain fatty acid biosynthetic process (GO:0042759)2.34113062
183positive regulation of reproductive process (GO:2000243)2.31732214
184nucleus organization (GO:0006997)2.31142238
185establishment of spindle orientation (GO:0051294)2.27048701
186dendrite morphogenesis (GO:0048813)2.26271393
187Rac protein signal transduction (GO:0016601)2.23274547
188regulation of meiosis (GO:0040020)2.22328437
189glutamate secretion (GO:0014047)2.22006042
190positive regulation of dendrite development (GO:1900006)2.21523005
191establishment of mitotic spindle orientation (GO:0000132)2.21521535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.42587323
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.28148892
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.95230051
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76990274
5E2F7_22180533_ChIP-Seq_HELA_Human2.74824268
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.68070879
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.62802731
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.57981622
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.41410120
10GBX2_23144817_ChIP-Seq_PC3_Human2.38303475
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06774022
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06207232
13EZH2_22144423_ChIP-Seq_EOC_Human2.00627238
14AR_21909140_ChIP-Seq_LNCAP_Human1.99067376
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96734772
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96098914
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93746752
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90453124
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.89107435
20DROSHA_22980978_ChIP-Seq_HELA_Human1.88770717
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.88735651
22* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86527053
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84726136
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78624534
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74423588
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74396723
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73225199
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71365720
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.70849692
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.70326128
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67985266
32* TP53_18474530_ChIP-ChIP_U2OS_Human1.67069350
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65124976
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63081480
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62254681
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61311616
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60907971
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59039339
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59010783
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59010783
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59010783
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58701991
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58054080
44REST_21632747_ChIP-Seq_MESCs_Mouse1.55331576
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55195929
46FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.54269064
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.54259897
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53562827
49EWS_26573619_Chip-Seq_HEK293_Human1.52760056
50* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52676709
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.52671428
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46807549
53* RNF2_27304074_Chip-Seq_NSC_Mouse1.43990260
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43879483
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.43750371
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.43406380
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43382490
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43382490
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43195692
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42801689
61* CBX2_27304074_Chip-Seq_ESCs_Mouse1.42465380
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41433603
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40276706
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39362301
65FUS_26573619_Chip-Seq_HEK293_Human1.37655222
66AHR_22903824_ChIP-Seq_MCF-7_Human1.37575365
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37407783
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37199460
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.35547517
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35136374
71* RNF2_27304074_Chip-Seq_ESCs_Mouse1.34565869
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34351084
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33066564
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.32368786
75* SMAD4_21799915_ChIP-Seq_A2780_Human1.30444666
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30078646
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29734989
78ZNF274_21170338_ChIP-Seq_K562_Hela1.29582397
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29232009
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.28127379
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27873589
82TP53_16413492_ChIP-PET_HCT116_Human1.27368208
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27012535
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27012535
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26705865
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.26611962
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25787138
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25787138
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25394404
90* EZH2_27304074_Chip-Seq_ESCs_Mouse1.24300777
91P300_19829295_ChIP-Seq_ESCs_Human1.23234332
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22658739
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22155812
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.21514556
95AR_21572438_ChIP-Seq_LNCaP_Human1.21492911
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.21208004
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20964507
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.19996831
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19050373
100AR_25329375_ChIP-Seq_VCAP_Human1.18327452
101* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16993779
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16802953
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15728200
104IRF1_19129219_ChIP-ChIP_H3396_Human1.15133591
105* TCF4_23295773_ChIP-Seq_U87_Human1.15045641
106* STAT3_23295773_ChIP-Seq_U87_Human1.14482586
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.12583800
108* AR_19668381_ChIP-Seq_PC3_Human1.12548997
109* SOX2_16153702_ChIP-ChIP_HESCs_Human1.12108177
110PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11345322
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11320875
112RXR_22108803_ChIP-Seq_LS180_Human1.10130425
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.09944831
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09907325
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09505825
116TAF15_26573619_Chip-Seq_HEK293_Human1.09423744
117* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08911278
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08750387
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08036207
120CBP_20019798_ChIP-Seq_JUKART_Human1.07613394
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07613394
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06556074
123BCAT_22108803_ChIP-Seq_LS180_Human1.05872414
124* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05515125
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05223724
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.04959801
127ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04634448
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04407328
129LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03747194
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.03511621
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03426254
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03354676
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02828724
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02715828
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02611578
136RARB_27405468_Chip-Seq_BRAIN_Mouse1.02395401
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01868784
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01863625
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01125358
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.00880915
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.99912754
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99848357
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99737003
144* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99644038
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99278298
146* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99151232
147FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98955826
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.98655304
149VDR_22108803_ChIP-Seq_LS180_Human0.98148559
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97742180
151GF1_26923725_Chip-Seq_HPCs_Mouse0.94871027
152CLOCK_20551151_ChIP-Seq_293T_Human0.94663656
153* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94428325
154SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93847353
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93832997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.81551961
2MP0002254_reproductive_system_inflammat4.41681061
3MP0009053_abnormal_anal_canal3.80740107
4MP0001346_abnormal_lacrimal_gland3.60590673
5MP0008789_abnormal_olfactory_epithelium3.29522151
6MP0003880_abnormal_central_pattern3.17940602
7MP0003718_maternal_effect3.05872640
8MP0009250_abnormal_appendicular_skeleto3.03554139
9MP0003385_abnormal_body_wall2.94751539
10MP0000762_abnormal_tongue_morphology2.91369327
11MP0005394_taste/olfaction_phenotype2.76836807
12MP0005499_abnormal_olfactory_system2.76836807
13MP0000537_abnormal_urethra_morphology2.65465886
14MP0000566_synostosis2.65210993
15MP0004859_abnormal_synaptic_plasticity2.57121867
16MP0002653_abnormal_ependyma_morphology2.52130434
17MP0004270_analgesia2.43952820
18MP0002233_abnormal_nose_morphology2.38518474
19MP0000534_abnormal_ureter_morphology2.24548783
20MP0000049_abnormal_middle_ear2.20419463
21MP0001502_abnormal_circadian_rhythm2.15853630
22MP0003879_abnormal_hair_cell2.15248652
23MP0003937_abnormal_limbs/digits/tail_de2.14892478
24MP0002734_abnormal_mechanical_nocicepti2.14841213
25MP0003123_paternal_imprinting2.14246661
26MP0005423_abnormal_somatic_nervous2.04551870
27MP0001984_abnormal_olfaction2.00875277
28MP0003690_abnormal_glial_cell1.96704579
29MP0002938_white_spotting1.94051922
30MP0003755_abnormal_palate_morphology1.93185423
31MP0001486_abnormal_startle_reflex1.92821150
32MP0003136_yellow_coat_color1.91620291
33MP0010368_abnormal_lymphatic_system1.91030959
34MP0003786_premature_aging1.89363161
35MP0002249_abnormal_larynx_morphology1.88233844
36MP0002877_abnormal_melanocyte_morpholog1.87642759
37MP0000613_abnormal_salivary_gland1.84982948
38MP0001270_distended_abdomen1.82318801
39MP0003635_abnormal_synaptic_transmissio1.80317144
40MP0003942_abnormal_urinary_system1.73689332
41MP0002272_abnormal_nervous_system1.70834980
42MP0005076_abnormal_cell_differentiation1.70669165
43MP0000428_abnormal_craniofacial_morphol1.69424912
44MP0000778_abnormal_nervous_system1.69129986
45MP0003121_genomic_imprinting1.68336817
46MP0002735_abnormal_chemical_nociception1.66879444
47MP0009780_abnormal_chondrocyte_physiolo1.66174978
48MP0009379_abnormal_foot_pigmentation1.64896434
49MP0003122_maternal_imprinting1.60622524
50MP0000678_abnormal_parathyroid_gland1.60137608
51MP0004134_abnormal_chest_morphology1.56579373
52MP0002063_abnormal_learning/memory/cond1.55767303
53MP0008995_early_reproductive_senescence1.54820030
54MP0004264_abnormal_extraembryonic_tissu1.54578642
55MP0002234_abnormal_pharynx_morphology1.52985269
56MP0003935_abnormal_craniofacial_develop1.52853441
57MP0003890_abnormal_embryonic-extraembry1.48398803
58MP0002932_abnormal_joint_morphology1.43459576
59MP0004147_increased_porphyrin_level1.43101218
60MP0000733_abnormal_muscle_development1.41820799
61MP0001299_abnormal_eye_distance/1.41814421
62MP0006276_abnormal_autonomic_nervous1.41077337
63MP0005187_abnormal_penis_morphology1.41018059
64MP0002116_abnormal_craniofacial_bone1.40779121
65MP0000538_abnormal_urinary_bladder1.39353934
66MP0004885_abnormal_endolymph1.38899718
67MP0001929_abnormal_gametogenesis1.37071917
68MP0010234_abnormal_vibrissa_follicle1.35350443
69MP0002064_seizures1.34345540
70MP0004233_abnormal_muscle_weight1.31105522
71MP0005167_abnormal_blood-brain_barrier1.29707699
72MP0001963_abnormal_hearing_physiology1.29149026
73MP0002557_abnormal_social/conspecific_i1.28809759
74MP0009745_abnormal_behavioral_response1.27654513
75MP0001340_abnormal_eyelid_morphology1.27607662
76MP0008877_abnormal_DNA_methylation1.27104768
77MP0000432_abnormal_head_morphology1.25507379
78MP0003705_abnormal_hypodermis_morpholog1.24816662
79MP0002638_abnormal_pupillary_reflex1.23742831
80MP0002177_abnormal_outer_ear1.23641418
81MP0003115_abnormal_respiratory_system1.23598583
82MP0003698_abnormal_male_reproductive1.21887882
83MP0003329_amyloid_beta_deposits1.21232374
84MP0003941_abnormal_skin_development1.20332480
85MP0002572_abnormal_emotion/affect_behav1.19886907
86MP0008057_abnormal_DNA_replication1.19351836
87MP0001968_abnormal_touch/_nociception1.17162083
88MP0000383_abnormal_hair_follicle1.16867081
89MP0002098_abnormal_vibrissa_morphology1.16718256
90MP0003699_abnormal_female_reproductive1.15372857
91MP0010094_abnormal_chromosome_stability1.13937065
92MP0002282_abnormal_trachea_morphology1.12260423
93MP0000467_abnormal_esophagus_morphology1.12097566
94MP0002109_abnormal_limb_morphology1.11286407
95MP0002161_abnormal_fertility/fecundity1.10662123
96MP0005377_hearing/vestibular/ear_phenot1.09273019
97MP0003878_abnormal_ear_physiology1.09273019
98MP0000026_abnormal_inner_ear1.08180825
99MP0000647_abnormal_sebaceous_gland1.07893968
100MP0003183_abnormal_peptide_metabolism1.07366414
101MP0009703_decreased_birth_body1.06873596
102MP0002210_abnormal_sex_determination1.04969343
103MP0000631_abnormal_neuroendocrine_gland1.04854125
104MP0005395_other_phenotype1.04813299
105MP0003119_abnormal_digestive_system1.04608987
106MP0005171_absent_coat_pigmentation1.04333742
107MP0002092_abnormal_eye_morphology1.03813905
108MP0001986_abnormal_taste_sensitivity1.03022196
109MP0009384_cardiac_valve_regurgitation1.02001770
110MP0000163_abnormal_cartilage_morphology1.01630188
111MP0006292_abnormal_olfactory_placode1.00700187
112MP0003936_abnormal_reproductive_system1.00654355
113MP0002152_abnormal_brain_morphology0.98289220
114MP0008875_abnormal_xenobiotic_pharmacok0.98286162
115MP0005670_abnormal_white_adipose0.96218733
116MP0001970_abnormal_pain_threshold0.95641988
117MP0001485_abnormal_pinna_reflex0.95621455
118MP0002733_abnormal_thermal_nociception0.95567049
119MP0003861_abnormal_nervous_system0.95181198
120MP0004043_abnormal_pH_regulation0.94692998
121MP0003938_abnormal_ear_development0.93906361
122MP0005367_renal/urinary_system_phenotyp0.92154159
123MP0000516_abnormal_urinary_system0.92154159
124MP0000579_abnormal_nail_morphology0.90490862
125MP0000955_abnormal_spinal_cord0.90050783
126MP0005410_abnormal_fertilization0.89439663
127MP0001501_abnormal_sleep_pattern0.88736358
128MP0000377_abnormal_hair_follicle0.88243722
129MP0002111_abnormal_tail_morphology0.87322046
130MP0002067_abnormal_sensory_capabilities0.86959251
131MP0005508_abnormal_skeleton_morphology0.85603965
132MP0000427_abnormal_hair_cycle0.85447617
133MP0002060_abnormal_skin_morphology0.84614505
134MP0010386_abnormal_urinary_bladder0.84348135
135MP0002114_abnormal_axial_skeleton0.84134689
136MP0002089_abnormal_postnatal_growth/wei0.83791824
137MP0010678_abnormal_skin_adnexa0.83550391
138MP0002160_abnormal_reproductive_system0.83449540
139MP0003633_abnormal_nervous_system0.82829605
140MP0005409_darkened_coat_color0.82803414
141MP0001664_abnormal_digestion0.82175574
142MP0005248_abnormal_Harderian_gland0.82172234
143MP0000653_abnormal_sex_gland0.81984190
144MP0003828_pulmonary_edema0.81683660
145MP0005646_abnormal_pituitary_gland0.79985475
146MP0002882_abnormal_neuron_morphology0.79124185
147MP0004808_abnormal_hematopoietic_stem0.79063655
148MP0001145_abnormal_male_reproductive0.79002487
149MP0002115_abnormal_skeleton_extremities0.78797017
150MP0005551_abnormal_eye_electrophysiolog0.78463573
151MP0005023_abnormal_wound_healing0.78312222
152MP0008569_lethality_at_weaning0.76972656
153MP0004811_abnormal_neuron_physiology0.75721132
154MP0002697_abnormal_eye_size0.75347443
155MP0002113_abnormal_skeleton_development0.75331604
156MP0005257_abnormal_intraocular_pressure0.75148680
157MP0002108_abnormal_muscle_morphology0.75037505
158MP0003632_abnormal_nervous_system0.74444768
159MP0003631_nervous_system_phenotype0.73497143
160MP0009278_abnormal_bone_marrow0.73462931
161MP0001293_anophthalmia0.73340904
162MP0002085_abnormal_embryonic_tissue0.73231286
163MP0009115_abnormal_fat_cell0.73170225
164MP0008007_abnormal_cellular_replicative0.72967034
165MP0001286_abnormal_eye_development0.72189522
166MP0005647_abnormal_sex_gland0.72099732
167MP0002396_abnormal_hematopoietic_system0.71630004
168MP0009672_abnormal_birth_weight0.71089518
169MP0003315_abnormal_perineum_morphology0.69840963
170MP0000627_abnormal_mammary_gland0.69618187
171MP0001177_atelectasis0.69269433

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.88645455
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.88645455
3Abnormality of the 4th metacarpal (HP:0010012)4.62467065
4Supernumerary spleens (HP:0009799)4.37108801
5Myokymia (HP:0002411)4.15483557
6Oligodactyly (hands) (HP:0001180)4.07088073
7Lip pit (HP:0100267)3.82999892
8Cutaneous finger syndactyly (HP:0010554)3.66966310
9Short middle phalanx of the 5th finger (HP:0004220)3.65745925
10Renal duplication (HP:0000075)3.38983198
11Hypoplastic labia majora (HP:0000059)3.37854630
12Mesomelia (HP:0003027)3.27394940
13Neurofibrillary tangles (HP:0002185)3.24452111
14Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.20942013
15Abdominal situs inversus (HP:0003363)3.20833089
16Abnormality of abdominal situs (HP:0011620)3.20833089
17Oligodactyly (HP:0012165)3.18817815
18Absent eyebrow (HP:0002223)3.18316156
19Short tibia (HP:0005736)3.17193306
20Septo-optic dysplasia (HP:0100842)3.13647032
21Gonadotropin excess (HP:0000837)3.10137615
22Abnormal tarsal ossification (HP:0008369)3.08649572
23Aplasia/Hypoplasia of the tibia (HP:0005772)3.07481905
24Cutaneous syndactyly (HP:0012725)3.05727338
25Abnormal foot bone ossification (HP:0010675)3.04741982
26Abnormality of the labia majora (HP:0012881)2.99771567
27Osteomalacia (HP:0002749)2.98594188
28Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.96699863
29Sex reversal (HP:0012245)2.92925726
30Abnormal sex determination (HP:0012244)2.92925726
31Abnormality of the phalanges of the 2nd finger (HP:0009541)2.90754696
32Bifid scrotum (HP:0000048)2.87762625
33Action tremor (HP:0002345)2.84797249
34Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.84574460
35Abnormality of the parietal bone (HP:0002696)2.83604272
36Increased circulating renin level (HP:0000848)2.81160262
37Impulsivity (HP:0100710)2.79793528
38Dysdiadochokinesis (HP:0002075)2.79620225
39Anomalous pulmonary venous return (HP:0010772)2.79604631
40Broad toe (HP:0001837)2.75770644
41Abnormality of the 2nd finger (HP:0004100)2.68704277
42Partial duplication of thumb phalanx (HP:0009944)2.67638183
43Abnormality of the phalanges of the 5th finger (HP:0004213)2.67259257
44Abnormal eating behavior (HP:0100738)2.60730188
45Neonatal short-limb short stature (HP:0008921)2.58785687
46Stomach cancer (HP:0012126)2.56033746
47Abnormality of the phalanges of the hallux (HP:0010057)2.51966655
48Short 5th finger (HP:0009237)2.48548152
49Hypoplastic scapulae (HP:0000882)2.46854164
50Aplasia/Hypoplasia of the scapulae (HP:0006713)2.46854164
51Abnormality of the pulmonary veins (HP:0011718)2.45390906
52Flat acetabular roof (HP:0003180)2.45154239
53Long clavicles (HP:0000890)2.45022637
54Wide anterior fontanel (HP:0000260)2.44807892
55Shallow orbits (HP:0000586)2.43989572
56Bifid tongue (HP:0010297)2.42485254
57Tubulointerstitial nephritis (HP:0001970)2.42010606
58Median cleft lip (HP:0000161)2.38854628
59Atresia of the external auditory canal (HP:0000413)2.37903732
60Down-sloping shoulders (HP:0200021)2.33997605
61Aplasia involving bones of the upper limbs (HP:0009823)2.33042873
62Aplasia of the phalanges of the hand (HP:0009802)2.33042873
63Aplasia involving bones of the extremities (HP:0009825)2.33042873
64Partial duplication of the phalanx of hand (HP:0009999)2.29206385
65Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.28760370
66Abnormality of the nasolacrimal system (HP:0000614)2.27257167
67Morphological abnormality of the inner ear (HP:0011390)2.26914200
68Anophthalmia (HP:0000528)2.26785681
69Selective tooth agenesis (HP:0001592)2.25431010
70Vitreoretinal degeneration (HP:0000655)2.24791942
71Narrow palate (HP:0000189)2.24337906
72Midline defect of the nose (HP:0004122)2.24175817
73Long eyelashes (HP:0000527)2.23816958
74Short clavicles (HP:0000894)2.19108451
75Increased number of teeth (HP:0011069)2.17781246
76Synostosis of carpal bones (HP:0005048)2.14936265
77Rhabdomyosarcoma (HP:0002859)2.13468399
78Limited hip movement (HP:0008800)2.13225464
79Broad hallux (HP:0010055)2.12857077
80Sparse scalp hair (HP:0002209)2.12438570
81Duplication of thumb phalanx (HP:0009942)2.11772556
82Fibular hypoplasia (HP:0003038)2.10016329
83Broad thumb (HP:0011304)2.09055177
84Abnormality of the ischium (HP:0003174)2.08892332
85Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.08036036
86Peripheral hypomyelination (HP:0007182)2.07041111
87Facial cleft (HP:0002006)2.06620943
88Hip contracture (HP:0003273)2.04809692
89Papillary thyroid carcinoma (HP:0002895)2.03382312
90Breast aplasia (HP:0100783)2.02741044
91Cupped ribs (HP:0000887)2.01129968
92Colon cancer (HP:0003003)2.01108421
93Abnormality of the distal phalanx of the thumb (HP:0009617)2.01051261
94Right ventricular cardiomyopathy (HP:0011663)2.00401234
95Tarsal synostosis (HP:0008368)2.00067972
96Aplasia/Hypoplasia of the fibula (HP:0006492)2.00030716
97Abnormality of the labia minora (HP:0012880)1.98950654
98Focal motor seizures (HP:0011153)1.98627496
99Aplasia/Hypoplasia of the clavicles (HP:0006710)1.98569301
100Hypoplasia of the maxilla (HP:0000327)1.97595145
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97350371
102Short middle phalanx of finger (HP:0005819)1.97245256
103Aplasia/Hypoplasia of the breasts (HP:0010311)1.96820333
104Ectopic kidney (HP:0000086)1.96775424
105Abnormality of the right ventricle (HP:0001707)1.96376895
106Short palpebral fissure (HP:0012745)1.96110058
107Absent septum pellucidum (HP:0001331)1.95810342
108Oligodontia (HP:0000677)1.94230832
109Renovascular hypertension (HP:0100817)1.94142657
110Labial hypoplasia (HP:0000066)1.93517417
111Abnormality of the fibula (HP:0002991)1.92383068
112Hypoplastic toenails (HP:0001800)1.91608231
113Abnormal ossification of hand bones (HP:0005921)1.91561801
114Preaxial foot polydactyly (HP:0001841)1.91160974
115Rectal prolapse (HP:0002035)1.91015359
116Abnormality of the nasal septum (HP:0000419)1.90812249
117Morphological abnormality of the middle ear (HP:0008609)1.89817499
118Abnormality of the distal phalanges of the toes (HP:0010182)1.89057803
119Facial hemangioma (HP:0000329)1.88865889
120Osteolytic defects of the hand bones (HP:0009699)1.88615468
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.88615468
122Erectile abnormalities (HP:0100639)1.88258920
123Abnormality of the septum pellucidum (HP:0007375)1.88108003
124Patellar dislocation (HP:0002999)1.87482210
125Progressive cerebellar ataxia (HP:0002073)1.87371299
126Cerebral inclusion bodies (HP:0100314)1.87220946
127Gait imbalance (HP:0002141)1.86839616
128Short metatarsal (HP:0010743)1.86659855
129Increased nuchal translucency (HP:0010880)1.85654021
130Primary amenorrhea (HP:0000786)1.85518419
131Maternal diabetes (HP:0009800)1.85280672
132Supranuclear gaze palsy (HP:0000605)1.84813141
133Ureteral stenosis (HP:0000071)1.84785126
134Volvulus (HP:0002580)1.84400151
135Abnormal hand bone ossification (HP:0010660)1.84317906
136Atrophic scars (HP:0001075)1.83294367
137Abnormality of carpal bone ossification (HP:0006257)1.83168333
138Truncal obesity (HP:0001956)1.83111305
139Abnormality of the labia (HP:0000058)1.82569482
140Nasolacrimal duct obstruction (HP:0000579)1.81990211
141Abnormality of the fovea (HP:0000493)1.80086965
142Carpal synostosis (HP:0009702)1.80083809
143Infertility (HP:0000789)1.79255349
144Elfin facies (HP:0004428)1.78513530
145Prostate neoplasm (HP:0100787)1.78432713
146Natal tooth (HP:0000695)1.77028879
147Genital tract atresia (HP:0001827)1.76996586
148Abnormality of cochlea (HP:0000375)1.76873202
149Synostosis involving bones of the feet (HP:0009140)1.76866221
150Synostosis involving bones of the lower limbs (HP:0009138)1.76866221
151Male infertility (HP:0003251)1.76208330
152Hypoplasia of the iris (HP:0007676)1.76140142
153Small hand (HP:0200055)1.75858872
154Breast carcinoma (HP:0003002)1.74594438
155Upper limb muscle weakness (HP:0003484)1.73848451
156Shawl scrotum (HP:0000049)1.73545091
157Absent radius (HP:0003974)1.71438522
158Microglossia (HP:0000171)1.71187487
159Trigonocephaly (HP:0000243)1.71064625
160Omphalocele (HP:0001539)1.71010025
161Hypoplasia of the fovea (HP:0007750)1.70954336
162Aplasia/Hypoplasia of the fovea (HP:0008060)1.70954336
163Neoplasm of striated muscle (HP:0009728)1.70783808
164Anterior segment dysgenesis (HP:0007700)1.70642587
165Delayed epiphyseal ossification (HP:0002663)1.67949121
166Abnormality of the intervertebral disk (HP:0005108)1.67830587
167Skin pits (HP:0100276)1.67711803
168Tracheal stenosis (HP:0002777)1.66973980
169Aplasia/Hypoplasia of the ulna (HP:0006495)1.66003687
170Tracheomalacia (HP:0002779)1.65871176
171Hyperaldosteronism (HP:0000859)1.62727077
172Bicornuate uterus (HP:0000813)1.62451473
173Abnormal auditory evoked potentials (HP:0006958)1.61529674
174Focal seizures (HP:0007359)1.61252451
175Diplopia (HP:0000651)1.61001739
176Abnormality of binocular vision (HP:0011514)1.61001739
177Vaginal atresia (HP:0000148)1.60500278
178Megalencephaly (HP:0001355)1.59778487
179Congenital primary aphakia (HP:0007707)1.59550655
180Abnormality of the diencephalon (HP:0010662)1.58682556
181Polyphagia (HP:0002591)1.58408962
182Lower limb asymmetry (HP:0100559)1.57302721
183Hyperactive renin-angiotensin system (HP:0000841)1.57187297
184Apathy (HP:0000741)1.57045220
185Optic nerve hypoplasia (HP:0000609)1.55688886
186Spinal cord compression (HP:0002176)1.54515441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.96890946
2EPHB24.07228838
3FRK3.70047287
4CDK193.35817006
5LATS13.29365084
6ARAF3.16670505
7MAP3K133.08306627
8MAP3K93.03829699
9NTRK32.89354452
10ZAK2.76445573
11LATS22.55586726
12NTRK22.45809540
13NUAK12.31499305
14RIPK12.29070432
15CDK122.25937232
16MKNK12.25100390
17TIE11.97843722
18PRKD31.88504932
19TYRO31.88335285
20ACVR1B1.87625302
21BRAF1.81852167
22ERBB21.77626706
23TTN1.73336240
24MAP2K21.72191104
25CDC71.69858083
26MET1.65702543
27TGFBR11.64708831
28MAP3K101.63108242
29CAMK1D1.62444008
30BMPR1B1.61714757
31PBK1.61705829
32MARK11.58412789
33RPS6KB21.57242111
34ERBB31.56273758
35DAPK21.55577344
36ATR1.49490670
37HIPK21.48633657
38EPHA31.48590394
39STK241.47660266
40TTK1.45385604
41PLK21.44583661
42KSR21.42622547
43DMPK1.40483166
44MKNK21.35997748
45SGK21.35507136
46CAMK1G1.32896712
47PDK21.32550420
48MARK21.32308208
49SGK4941.30655410
50SGK2231.30655410
51CSNK1A1L1.27946458
52NLK1.22553195
53PDK31.22530133
54PDK41.22530133
55CSNK1G11.22239742
56DDR21.19429617
57STK38L1.18570851
58SIK11.17291146
59CAMK11.15359507
60CASK1.14037964
61CDK81.10046822
62TNIK1.09637758
63PAK31.06791262
64MAP3K31.06612559
65PAK21.06471585
66NTRK11.05703595
67MAP3K21.05388794
68NEK91.05124585
69NEK61.03961036
70MAP4K21.03616555
71CDK61.02034372
72PDGFRA1.01065349
73EPHB11.01041672
74MTOR1.00865404
75SCYL21.00851793
76RET0.99946129
77TNK20.97755346
78STK380.95233732
79PLK40.95138187
80PINK10.94960473
81MAPK130.93125342
82MAP3K70.91497865
83CHEK20.90604812
84ATM0.90314252
85MAP3K40.89522119
86MAP3K60.89450836
87PTK60.88586989
88SIK30.87938859
89MAP2K40.87768675
90EEF2K0.87689241
91MINK10.87132688
92CDK50.86635510
93PAK40.86573652
94RAF10.84031707
95CHEK10.81343773
96DYRK1A0.81193542
97MAP2K60.80651575
98DYRK30.78158732
99CSNK1G30.77672083
100DYRK20.77487210
101ERBB40.76838247
102CAMK40.75061773
103INSRR0.74238248
104PKN10.73795312
105STK30.73133909
106SGK30.72805472
107CAMK2A0.71692178
108AKT30.71278438
109CDK11A0.70535399
110SGK10.70493281
111UHMK10.70357778
112EPHA20.70264320
113MELK0.69606508
114MAPK10.68852726
115BRD40.67638882
116BRSK10.67291869
117MAP2K30.66832007
118PIK3CA0.65376155
119CAMKK10.63213090
120MAPK70.63089340
121MAPK100.62865346
122WNK30.62655389
123CDK40.61024441
124DYRK1B0.60696082
125MOS0.59063679
126RPS6KA10.58120187
127MAPK30.57976771
128CDK150.57727212
129PASK0.57665601
130STK390.57366444
131CAMK2B0.56728375
132PKN20.56319377
133BMX0.56291146
134NEK20.55863370
135CDC42BPA0.55758582
136FGFR20.55714902
137PRKG10.53826752
138CSNK1G20.53545314
139PLK30.53536975
140MAPK140.53230816
141PTK20.53069266
142CDK180.52951372
143CAMK2G0.51882125
144PDGFRB0.51288362
145BCKDK0.50649823
146WNK10.50137570
147MYLK0.49407783
148CDK70.49398359
149ROCK20.49165468
150CDK140.48162050
151PRKCZ0.47981225
152CDK10.47846449
153AURKA0.45927329
154PRKDC0.45756694
155CDK90.45690167
156IRAK20.45140337
157PRKCG0.44285843
158CDK30.43995326
159STK110.41879542
160PLK10.39185915
161CDK20.39165168
162OXSR10.38613621
163AKT10.37696629
164MAP2K70.35537769
165LMTK20.34299496
166ICK0.32467606
167AURKB0.32246639
168RPS6KL10.32093628
169RPS6KC10.32093628

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.66367125
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15796412
3Steroid hormone biosynthesis_Homo sapiens_hsa001402.78988465
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55909292
5Hippo signaling pathway_Homo sapiens_hsa043902.45102913
6Hedgehog signaling pathway_Homo sapiens_hsa043402.38611332
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37400258
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.30332951
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.29626403
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16944732
11Notch signaling pathway_Homo sapiens_hsa043302.13393240
12Nicotine addiction_Homo sapiens_hsa050332.11898127
13Insulin secretion_Homo sapiens_hsa049112.01730330
14Chemical carcinogenesis_Homo sapiens_hsa052041.94847139
15Circadian entrainment_Homo sapiens_hsa047131.94422676
16GABAergic synapse_Homo sapiens_hsa047271.93458859
17Morphine addiction_Homo sapiens_hsa050321.90547024
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.88610828
19Cell cycle_Homo sapiens_hsa041101.80047386
20Transcriptional misregulation in cancer_Homo sapiens_hsa052021.79841133
21Dorso-ventral axis formation_Homo sapiens_hsa043201.78866487
22TGF-beta signaling pathway_Homo sapiens_hsa043501.77190569
23ABC transporters_Homo sapiens_hsa020101.76882367
24Adherens junction_Homo sapiens_hsa045201.67635080
25HTLV-I infection_Homo sapiens_hsa051661.66505181
26Glutamatergic synapse_Homo sapiens_hsa047241.64168872
27RNA degradation_Homo sapiens_hsa030181.61721900
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59499547
29Gastric acid secretion_Homo sapiens_hsa049711.57814522
30Histidine metabolism_Homo sapiens_hsa003401.54510663
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52892918
32Wnt signaling pathway_Homo sapiens_hsa043101.51775916
33Ovarian steroidogenesis_Homo sapiens_hsa049131.50424469
34Axon guidance_Homo sapiens_hsa043601.49355465
35MicroRNAs in cancer_Homo sapiens_hsa052061.42931101
36Thyroid cancer_Homo sapiens_hsa052161.41097549
37mRNA surveillance pathway_Homo sapiens_hsa030151.40467437
38Long-term potentiation_Homo sapiens_hsa047201.39970433
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38355228
40Olfactory transduction_Homo sapiens_hsa047401.36588366
41Circadian rhythm_Homo sapiens_hsa047101.34939065
42Melanogenesis_Homo sapiens_hsa049161.33137567
43Prostate cancer_Homo sapiens_hsa052151.32667589
44Graft-versus-host disease_Homo sapiens_hsa053321.31901029
45Synaptic vesicle cycle_Homo sapiens_hsa047211.30335279
46Pathways in cancer_Homo sapiens_hsa052001.29653054
47Long-term depression_Homo sapiens_hsa047301.27748804
48Salivary secretion_Homo sapiens_hsa049701.27421510
49Fatty acid biosynthesis_Homo sapiens_hsa000611.25278272
50Retinol metabolism_Homo sapiens_hsa008301.23246876
51Colorectal cancer_Homo sapiens_hsa052101.23089698
52Amphetamine addiction_Homo sapiens_hsa050311.22509871
53Glutathione metabolism_Homo sapiens_hsa004801.22043378
54Herpes simplex infection_Homo sapiens_hsa051681.21416708
55Propanoate metabolism_Homo sapiens_hsa006401.20253357
56Cholinergic synapse_Homo sapiens_hsa047251.17871733
57Arginine and proline metabolism_Homo sapiens_hsa003301.15753162
58Dopaminergic synapse_Homo sapiens_hsa047281.15742696
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14429811
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13496371
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12550408
62* Proteoglycans in cancer_Homo sapiens_hsa052051.11320155
63Endometrial cancer_Homo sapiens_hsa052131.09644833
64Taste transduction_Homo sapiens_hsa047421.08500609
65Tight junction_Homo sapiens_hsa045301.06923412
66Cocaine addiction_Homo sapiens_hsa050301.05883806
67Phospholipase D signaling pathway_Homo sapiens_hsa040721.05692496
68ECM-receptor interaction_Homo sapiens_hsa045121.05276111
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05020957
70Fanconi anemia pathway_Homo sapiens_hsa034601.04809035
71Vascular smooth muscle contraction_Homo sapiens_hsa042701.02709911
72Pancreatic secretion_Homo sapiens_hsa049721.02408317
73Oxytocin signaling pathway_Homo sapiens_hsa049211.01844869
74Inositol phosphate metabolism_Homo sapiens_hsa005621.01085911
75Hepatitis B_Homo sapiens_hsa051611.00830064
76Lysine degradation_Homo sapiens_hsa003100.97134387
77Basal transcription factors_Homo sapiens_hsa030220.96752156
78Butanoate metabolism_Homo sapiens_hsa006500.96690553
79Starch and sucrose metabolism_Homo sapiens_hsa005000.95993538
80Homologous recombination_Homo sapiens_hsa034400.94323243
81Focal adhesion_Homo sapiens_hsa045100.94053734
82Fatty acid elongation_Homo sapiens_hsa000620.93453390
83Small cell lung cancer_Homo sapiens_hsa052220.93299188
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.92792940
85Insulin resistance_Homo sapiens_hsa049310.89452313
86African trypanosomiasis_Homo sapiens_hsa051430.88969890
87Calcium signaling pathway_Homo sapiens_hsa040200.88332906
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88291536
89Bladder cancer_Homo sapiens_hsa052190.87853956
90Nitrogen metabolism_Homo sapiens_hsa009100.87015468
91Fatty acid metabolism_Homo sapiens_hsa012120.86540279
92Serotonergic synapse_Homo sapiens_hsa047260.85506520
93Arginine biosynthesis_Homo sapiens_hsa002200.84983942
94TNF signaling pathway_Homo sapiens_hsa046680.83156174
95Type II diabetes mellitus_Homo sapiens_hsa049300.81209087
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80653391
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77653303
98Thyroid hormone synthesis_Homo sapiens_hsa049180.75970615
99Amoebiasis_Homo sapiens_hsa051460.75665451
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75441069
101PPAR signaling pathway_Homo sapiens_hsa033200.75019767
102Prion diseases_Homo sapiens_hsa050200.74992356
103RNA transport_Homo sapiens_hsa030130.73808508
104Ras signaling pathway_Homo sapiens_hsa040140.73337267
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72978808
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71542729
107Influenza A_Homo sapiens_hsa051640.66045324
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65393361
109ErbB signaling pathway_Homo sapiens_hsa040120.64222145
110cAMP signaling pathway_Homo sapiens_hsa040240.64009563
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63799601
112FoxO signaling pathway_Homo sapiens_hsa040680.63641663
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61857099
114beta-Alanine metabolism_Homo sapiens_hsa004100.60817648
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59944247
116Spliceosome_Homo sapiens_hsa030400.59630130
117AMPK signaling pathway_Homo sapiens_hsa041520.59404916
118Sulfur metabolism_Homo sapiens_hsa009200.57500373
119mTOR signaling pathway_Homo sapiens_hsa041500.57443390
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56929146
121Systemic lupus erythematosus_Homo sapiens_hsa053220.56240230
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55744052
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54663218
124Glycerolipid metabolism_Homo sapiens_hsa005610.54358642
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54181632
126Pertussis_Homo sapiens_hsa051330.53731536
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53705302
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51380444
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51034648
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50639641
131Fatty acid degradation_Homo sapiens_hsa000710.50133790
132Oocyte meiosis_Homo sapiens_hsa041140.49602816
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.49570846
134Protein digestion and absorption_Homo sapiens_hsa049740.49136725
135Prolactin signaling pathway_Homo sapiens_hsa049170.47966200
136Selenocompound metabolism_Homo sapiens_hsa004500.47622422
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47510227
138GnRH signaling pathway_Homo sapiens_hsa049120.46942943
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.46870882
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.46733032
141Viral carcinogenesis_Homo sapiens_hsa052030.46722388
142Renin-angiotensin system_Homo sapiens_hsa046140.44863599
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44004960
144Renin secretion_Homo sapiens_hsa049240.43077065
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43000287
146Salmonella infection_Homo sapiens_hsa051320.42757893
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40760208
148Bile secretion_Homo sapiens_hsa049760.40441978
149Rap1 signaling pathway_Homo sapiens_hsa040150.40341001
150Choline metabolism in cancer_Homo sapiens_hsa052310.40245941
151Gap junction_Homo sapiens_hsa045400.40034936
152Dilated cardiomyopathy_Homo sapiens_hsa054140.39630400
153Estrogen signaling pathway_Homo sapiens_hsa049150.37301258
154Mineral absorption_Homo sapiens_hsa049780.37085530
155p53 signaling pathway_Homo sapiens_hsa041150.36692297
156DNA replication_Homo sapiens_hsa030300.36683674
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36261230
158Melanoma_Homo sapiens_hsa052180.36156250
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36113580
160Vitamin digestion and absorption_Homo sapiens_hsa049770.34225830

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