HPX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.72722021
2epoxygenase P450 pathway (GO:0019373)8.03841361
3omega-hydroxylase P450 pathway (GO:0097267)7.91732134
4L-phenylalanine catabolic process (GO:0006559)7.30402088
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30402088
6L-phenylalanine metabolic process (GO:0006558)7.07222891
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07222891
8aromatic amino acid family catabolic process (GO:0009074)6.64671493
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.57719233
10indole-containing compound catabolic process (GO:0042436)6.11217229
11indolalkylamine catabolic process (GO:0046218)6.11217229
12tryptophan catabolic process (GO:0006569)6.11217229
13negative regulation of fibrinolysis (GO:0051918)6.02774850
14high-density lipoprotein particle remodeling (GO:0034375)6.00593874
15kynurenine metabolic process (GO:0070189)5.94613378
16drug metabolic process (GO:0017144)5.83350831
17urea cycle (GO:0000050)5.76115218
18urea metabolic process (GO:0019627)5.76115218
19bile acid biosynthetic process (GO:0006699)5.73089847
20regulation of fibrinolysis (GO:0051917)5.71933406
21tryptophan metabolic process (GO:0006568)5.71142457
22regulation of cholesterol esterification (GO:0010872)5.69461578
23oxidative demethylation (GO:0070989)5.68931713
24regulation of protein activation cascade (GO:2000257)5.65241273
25glyoxylate metabolic process (GO:0046487)5.56382131
26complement activation, alternative pathway (GO:0006957)5.55371201
27protein carboxylation (GO:0018214)5.52255399
28peptidyl-glutamic acid carboxylation (GO:0017187)5.52255399
29alpha-linolenic acid metabolic process (GO:0036109)5.36590647
30nitrogen cycle metabolic process (GO:0071941)5.28243742
31phospholipid efflux (GO:0033700)5.20875272
32regulation of complement activation (GO:0030449)5.20123626
33protein-lipid complex remodeling (GO:0034368)5.17630325
34macromolecular complex remodeling (GO:0034367)5.17630325
35plasma lipoprotein particle remodeling (GO:0034369)5.17630325
36reverse cholesterol transport (GO:0043691)5.12868447
37regulation of triglyceride catabolic process (GO:0010896)5.08003820
38phenylpropanoid metabolic process (GO:0009698)5.03874571
39cysteine metabolic process (GO:0006534)5.01716850
40sulfur amino acid catabolic process (GO:0000098)5.01539247
41negative regulation of sterol transport (GO:0032372)4.92850320
42negative regulation of cholesterol transport (GO:0032375)4.92850320
43serine family amino acid catabolic process (GO:0009071)4.92414494
44bile acid metabolic process (GO:0008206)4.90294825
45aromatic amino acid family metabolic process (GO:0009072)4.83345012
46negative regulation of blood coagulation (GO:0030195)4.82583753
47negative regulation of hemostasis (GO:1900047)4.82583753
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82169397
49ethanol metabolic process (GO:0006067)4.81690042
50plasma lipoprotein particle clearance (GO:0034381)4.72014231
51tyrosine metabolic process (GO:0006570)4.63385859
52cholesterol efflux (GO:0033344)4.59740859
53acylglycerol homeostasis (GO:0055090)4.59734305
54triglyceride homeostasis (GO:0070328)4.59734305
55acute-phase response (GO:0006953)4.54986540
56* regulation of humoral immune response (GO:0002920)4.48104175
57homocysteine metabolic process (GO:0050667)4.46936646
58alpha-amino acid catabolic process (GO:1901606)4.46017776
59plasma lipoprotein particle assembly (GO:0034377)4.45034496
60S-adenosylmethionine metabolic process (GO:0046500)4.43630655
61negative regulation of coagulation (GO:0050819)4.39293018
62negative regulation of wound healing (GO:0061045)4.37028546
63amino-acid betaine metabolic process (GO:0006577)4.36083036
64lysine metabolic process (GO:0006553)4.35479516
65lysine catabolic process (GO:0006554)4.35479516
66indolalkylamine metabolic process (GO:0006586)4.28642588
67fibrinolysis (GO:0042730)4.27455981
68benzene-containing compound metabolic process (GO:0042537)4.26848751
69very-low-density lipoprotein particle assembly (GO:0034379)4.24681929
70cellular biogenic amine catabolic process (GO:0042402)4.21166158
71amine catabolic process (GO:0009310)4.21166158
72coenzyme catabolic process (GO:0009109)4.19016773
73bile acid and bile salt transport (GO:0015721)4.18833863
74negative regulation of lipase activity (GO:0060192)4.13898239
75glycine metabolic process (GO:0006544)4.13509626
76low-density lipoprotein particle remodeling (GO:0034374)4.11787499
77positive regulation of hemostasis (GO:1900048)4.08143669
78positive regulation of blood coagulation (GO:0030194)4.08143669
79cellular amino acid catabolic process (GO:0009063)4.07084068
80disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.06417821
81killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.06417821
82cellular ketone body metabolic process (GO:0046950)4.06132100
83alkaloid metabolic process (GO:0009820)4.04722701
84glutamate metabolic process (GO:0006536)4.04134156
85cellular glucuronidation (GO:0052695)4.03177240
86opsonization (GO:0008228)4.03038716
87imidazole-containing compound metabolic process (GO:0052803)4.01633915
88positive regulation of triglyceride lipase activity (GO:0061365)4.01288019
89positive regulation of lipoprotein lipase activity (GO:0051006)4.01288019
90arginine metabolic process (GO:0006525)4.01212767
91blood coagulation, intrinsic pathway (GO:0007597)4.01150504
92protein-lipid complex assembly (GO:0065005)3.98403573
93drug catabolic process (GO:0042737)3.97704781
94serine family amino acid metabolic process (GO:0009069)3.97087350
95positive regulation of lipid catabolic process (GO:0050996)3.96545448
96hormone catabolic process (GO:0042447)3.94991058
97dicarboxylic acid biosynthetic process (GO:0043650)3.94732495
98complement activation, classical pathway (GO:0006958)3.93105552
99plasma lipoprotein particle organization (GO:0071827)3.91470554
100protein activation cascade (GO:0072376)3.89010991
101cellular modified amino acid catabolic process (GO:0042219)3.87772724
102complement activation (GO:0006956)3.85664221
103negative regulation of protein activation cascade (GO:2000258)3.85042390
104cofactor catabolic process (GO:0051187)3.83434718
105aldehyde catabolic process (GO:0046185)3.81634192
106serine family amino acid biosynthetic process (GO:0009070)3.79219948
107positive regulation of coagulation (GO:0050820)3.77491374
108ethanol oxidation (GO:0006069)3.75779647
109cholesterol homeostasis (GO:0042632)3.75777162
110acute inflammatory response (GO:0002526)3.73815382
111phospholipid homeostasis (GO:0055091)3.73419033
112intestinal cholesterol absorption (GO:0030299)3.70501955
113sterol homeostasis (GO:0055092)3.69479355
114positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.68931108
115protein-lipid complex subunit organization (GO:0071825)3.67850272
116positive regulation of fatty acid beta-oxidation (GO:0032000)3.67816672
117lipoprotein metabolic process (GO:0042157)3.65448227
118response to nitrosative stress (GO:0051409)3.64262778
119cytolysis (GO:0019835)3.61595417
120regulation of plasminogen activation (GO:0010755)3.58817392
121negative regulation of complement activation (GO:0045916)3.57755970
122regulation of lipoprotein particle clearance (GO:0010984)3.57081705
123flavonoid metabolic process (GO:0009812)3.56733784
124uronic acid metabolic process (GO:0006063)3.56584996
125glucuronate metabolic process (GO:0019585)3.56584996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.21635615
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10495581
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.10162727
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.38202568
5* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.32965607
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29446697
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16360011
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.19345236
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.11578067
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03014508
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0273828
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98212346
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97135050
14CLOCK_20551151_ChIP-Seq_293T_Human1.61568303
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60430026
16HTT_18923047_ChIP-ChIP_STHdh_Human1.46606728
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45353147
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.40539300
19GATA1_22025678_ChIP-Seq_K562_Human1.31020069
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28498069
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27885824
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18222132
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16820944
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13694248
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10931759
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.06564735
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00673238
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00043497
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95931226
30RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92778365
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89183966
32CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86562583
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82302220
34HNFA_21074721_ChIP-Seq_CACO-2_Human0.81847248
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81578748
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79201340
37SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79178016
38PHF8_20622853_ChIP-Seq_HELA_Human0.79124093
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78485014
40GATA4_25053715_ChIP-Seq_YYC3_Human0.76325956
41KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73408595
42RARA_24833708_ChIP-Seq_LIVER_Mouse0.73089129
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73067696
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72875934
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72598850
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72421348
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72305515
48GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.71762184
49ESR2_21235772_ChIP-Seq_MCF-7_Human0.70759374
50SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69959815
51ZNF263_19887448_ChIP-Seq_K562_Human0.68946718
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67495605
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67430153
54NFE2_27457419_Chip-Seq_LIVER_Mouse0.67138563
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66567080
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.66424910
57SOX2_21211035_ChIP-Seq_LN229_Human0.66406872
58NFYA_21822215_ChIP-Seq_K562_Human0.66061699
59TP53_18474530_ChIP-ChIP_U2OS_Human0.65976266
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65781181
61NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65257767
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65257767
63TRIM28_21343339_ChIP-Seq_HEK293_Human0.63369990
64IRF1_19129219_ChIP-ChIP_H3396_Human0.62804778
65PIAS1_25552417_ChIP-Seq_VCAP_Human0.62661448
66* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62402877
67ETV2_25802403_ChIP-Seq_MESCs_Mouse0.61769345
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.61460818
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60523084
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59782943
71CBX2_22325352_ChIP-Seq_293T-Rex_Human0.59685072
72RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59507368
73RARB_24833708_ChIP-Seq_LIVER_Mouse0.59126519
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.58574946
75RAC3_21632823_ChIP-Seq_H3396_Human0.57350611
76CEBPB_22108803_ChIP-Seq_LS180_Human0.57309345
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55575491
78STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54383023
79LXR_22292898_ChIP-Seq_THP-1_Human0.53345377
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.53109945
81ER_23166858_ChIP-Seq_MCF-7_Human0.52291554
82AR_20517297_ChIP-Seq_VCAP_Human0.51812443
83ETV1_20927104_ChIP-Seq_GIST48_Human0.51110240
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.50940102
85* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.50266563
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.50255039
87MYC_19829295_ChIP-Seq_ESCs_Human0.49956635
88EGR1_19032775_ChIP-ChIP_M12_Human0.49675304
89SPI1_20517297_ChIP-Seq_HL60_Human0.49397774
90FOXA1_25552417_ChIP-Seq_VCAP_Human0.49341978
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.48915692
92CDX2_20551321_ChIP-Seq_CACO-2_Human0.48254296
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.47309589
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46750468
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46527037
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.46488834
97GATA3_24758297_ChIP-Seq_MCF-7_Human0.46369870
98* CTCF_27219007_Chip-Seq_Bcells_Human0.46313523
99MYC_19915707_ChIP-ChIP_AK7_Human0.46285285
100P53_21459846_ChIP-Seq_SAOS-2_Human0.45483466
101BCAT_22108803_ChIP-Seq_LS180_Human0.45277074
102PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44216340
103* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44146230
104ESET_19884257_ChIP-Seq_ESCs_Mouse0.43011108
105* CBP_21632823_ChIP-Seq_H3396_Human0.41974862
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40914953
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40783774
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40763380
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40456996
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40334416
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.40025357
112STAT1_17558387_ChIP-Seq_HELA_Human0.39703603
113GATA2_19941826_ChIP-Seq_K562_Human0.39182562
114TAF2_19829295_ChIP-Seq_ESCs_Human0.39036369
115GATA1_19941826_ChIP-Seq_K562_Human0.37519363
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.37315226
117SOX2_20726797_ChIP-Seq_SW620_Human0.37301090
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37141915
119TAF15_26573619_Chip-Seq_HEK293_Human0.36893697
120SPI1_26923725_Chip-Seq_HPCs_Mouse0.36431952
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.36314716
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.35982424
123MYC_27129775_Chip-Seq_CORNEA_Mouse0.35648023
124CDX2_22108803_ChIP-Seq_LS180_Human0.34951897
125* GATA6_25053715_ChIP-Seq_YYC3_Human0.34872471
126* FOXH1_21741376_ChIP-Seq_EPCs_Human0.33835966
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33393777
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.32560467
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.31990311
130* NCOR_22424771_ChIP-Seq_293T_Human0.31981629
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.31598076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.46479898
2MP0005360_urolithiasis7.41006476
3MP0005085_abnormal_gallbladder_physiolo6.38150864
4MP0005365_abnormal_bile_salt6.31952993
5MP0008875_abnormal_xenobiotic_pharmacok4.95300419
6MP0003806_abnormal_nucleotide_metabolis4.06123410
7MP0003252_abnormal_bile_duct3.75793045
8MP0010329_abnormal_lipoprotein_level3.60724993
9MP0009840_abnormal_foam_cell3.58347683
10MP0005083_abnormal_biliary_tract3.03160056
11MP0003191_abnormal_cellular_cholesterol2.84983388
12MP0003195_calcinosis2.75492188
13MP0005332_abnormal_amino_acid2.72775849
14MP0001666_abnormal_nutrient_absorption2.56324885
15MP0000609_abnormal_liver_physiology2.17867258
16MP0002118_abnormal_lipid_homeostasis2.09127562
17MP0002138_abnormal_hepatobiliary_system2.06694499
18MP0004019_abnormal_vitamin_homeostasis2.04730026
19MP0005319_abnormal_enzyme/_coenzyme1.79752924
20MP0003868_abnormal_feces_composition1.77324357
21MP0009697_abnormal_copulation1.67747869
22MP0001764_abnormal_homeostasis1.64290158
23MP0003011_delayed_dark_adaptation1.52894127
24MP0005584_abnormal_enzyme/coenzyme_acti1.50952935
25MP0000604_amyloidosis1.25333286
26MP0003186_abnormal_redox_activity1.19159395
27MP0003656_abnormal_erythrocyte_physiolo1.18682767
28* MP0009643_abnormal_urine_homeostasis1.17263591
29MP0005451_abnormal_body_composition1.16920383
30MP0000598_abnormal_liver_morphology1.16711592
31MP0009764_decreased_sensitivity_to1.14541597
32MP0005647_abnormal_sex_gland1.11957730
33MP0003705_abnormal_hypodermis_morpholog1.11035056
34MP0009763_increased_sensitivity_to1.09264997
35MP0002254_reproductive_system_inflammat1.03905537
36MP0010368_abnormal_lymphatic_system0.97562219
37* MP0008469_abnormal_protein_level0.91878124
38* MP0005636_abnormal_mineral_homeostasis0.90805847
39* MP0009642_abnormal_blood_homeostasis0.88726669
40MP0005670_abnormal_white_adipose0.87751420
41MP0001915_intracranial_hemorrhage0.86333083
42MP0009765_abnormal_xenobiotic_induced0.80186580
43MP0005084_abnormal_gallbladder_morpholo0.80049173
44MP0005376_homeostasis/metabolism_phenot0.79505472
45MP0003690_abnormal_glial_cell0.79210685
46MP0005408_hypopigmentation0.78702356
47MP0009053_abnormal_anal_canal0.76641670
48MP0006036_abnormal_mitochondrial_physio0.75880908
49MP0005187_abnormal_penis_morphology0.74484402
50MP0002078_abnormal_glucose_homeostasis0.74463873
51MP0002282_abnormal_trachea_morphology0.73130036
52MP0002971_abnormal_brown_adipose0.73014263
53MP0005220_abnormal_exocrine_pancreas0.73009609
54MP0003329_amyloid_beta_deposits0.72606284
55MP0002876_abnormal_thyroid_physiology0.69438634
56MP0001661_extended_life_span0.68534810
57MP0003879_abnormal_hair_cell0.68481810
58MP0005464_abnormal_platelet_physiology0.68057232
59MP0005334_abnormal_fat_pad0.67573407
60MP0005058_abnormal_lysosome_morphology0.65046826
61MP0000639_abnormal_adrenal_gland0.63152870
62MP0005535_abnormal_body_temperature0.60873464
63MP0004130_abnormal_muscle_cell0.60319038
64MP0001986_abnormal_taste_sensitivity0.60285056
65MP0005266_abnormal_metabolism0.57923296
66MP0001756_abnormal_urination0.57101575
67MP0005448_abnormal_energy_balance0.52751017
68MP0002249_abnormal_larynx_morphology0.51963460
69MP0005395_other_phenotype0.51546287
70MP0006035_abnormal_mitochondrial_morpho0.48275888
71MP0004272_abnormal_basement_membrane0.48113234
72MP0008873_increased_physiological_sensi0.47641936
73MP0003436_decreased_susceptibility_to0.46902518
74MP0003724_increased_susceptibility_to0.46862992
75MP0003638_abnormal_response/metabolism_0.46472116
76MP0008874_decreased_physiological_sensi0.45175530
77MP0003075_altered_response_to0.44258376
78MP0003718_maternal_effect0.42170699
79MP0009785_altered_susceptibility_to0.41843066
80MP0002822_catalepsy0.41763557
81MP0002928_abnormal_bile_duct0.41507235
82MP0005166_decreased_susceptibility_to0.41414914
83* MP0002136_abnormal_kidney_physiology0.41222227
84MP0000579_abnormal_nail_morphology0.41192576
85MP0003953_abnormal_hormone_level0.38539065
86MP0004883_abnormal_blood_vessel0.38153331
87MP0001881_abnormal_mammary_gland0.37089573
88MP0005666_abnormal_adipose_tissue0.37046168
89MP0000467_abnormal_esophagus_morphology0.36657615
90MP0005248_abnormal_Harderian_gland0.35916513
91MP0000249_abnormal_blood_vessel0.35767987
92MP0009384_cardiac_valve_regurgitation0.34533034
93MP0009115_abnormal_fat_cell0.34047353
94MP0005164_abnormal_response_to0.33532895
95MP0000566_synostosis0.33406110
96MP0001243_abnormal_dermal_layer0.32447155
97MP0002168_other_aberrant_phenotype0.32291072
98MP0008872_abnormal_physiological_respon0.31875110
99MP0001845_abnormal_inflammatory_respons0.31205332
100MP0005023_abnormal_wound_healing0.30875289
101MP0002837_dystrophic_cardiac_calcinosis0.30850438
102MP0002796_impaired_skin_barrier0.29782954
103MP0002970_abnormal_white_adipose0.29661629
104MP0004782_abnormal_surfactant_physiolog0.29583223
105MP0009672_abnormal_birth_weight0.28944402
106MP0001853_heart_inflammation0.28535220
107MP0006082_CNS_inflammation0.28037149
108MP0002089_abnormal_postnatal_growth/wei0.26917111
109MP0003632_abnormal_nervous_system0.26650727
110MP0004381_abnormal_hair_follicle0.25940313
111MP0005167_abnormal_blood-brain_barrier0.24737024
112MP0002132_abnormal_respiratory_system0.24647486
113MP0000230_abnormal_systemic_arterial0.24272685
114MP0000920_abnormal_myelination0.23933735
115MP0002128_abnormal_blood_circulation0.23529265
116MP0001851_eye_inflammation0.22568789
117MP0002090_abnormal_vision0.20584542
118MP0003941_abnormal_skin_development0.19430952
119MP0002332_abnormal_exercise_endurance0.19327192
120MP0002295_abnormal_pulmonary_circulatio0.18596501
121MP0005197_abnormal_uvea_morphology0.17538895

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.56040938
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.17170218
3Intrahepatic cholestasis (HP:0001406)7.08893642
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.85375771
5Prolonged partial thromboplastin time (HP:0003645)6.81672046
6Hypobetalipoproteinemia (HP:0003563)6.51288945
7Xanthomatosis (HP:0000991)6.29392864
8Complement deficiency (HP:0004431)5.75439007
9Hyperlipoproteinemia (HP:0010980)5.60307906
10Joint hemorrhage (HP:0005261)5.02644381
11Abnormality of the common coagulation pathway (HP:0010990)4.93054062
12Hypolipoproteinemia (HP:0010981)4.92960344
13Hyperammonemia (HP:0001987)4.51532766
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.50660908
15Epidermoid cyst (HP:0200040)4.46057757
16Hypoalphalipoproteinemia (HP:0003233)4.33525859
17Abnormality of methionine metabolism (HP:0010901)4.23102406
18Abnormality of complement system (HP:0005339)4.20406045
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.14457146
20Fat malabsorption (HP:0002630)4.13066195
21Ketosis (HP:0001946)4.12059859
22Hyperglycinemia (HP:0002154)4.11731389
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04646581
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.03175123
25Hypoglycemic coma (HP:0001325)3.94250735
26Abnormality of pyrimidine metabolism (HP:0004353)3.93248269
27Abnormality of the intrinsic pathway (HP:0010989)3.86203677
28Spontaneous abortion (HP:0005268)3.82853311
29Hypercholesterolemia (HP:0003124)3.69905748
30Conjugated hyperbilirubinemia (HP:0002908)3.63245693
31Abnormality of glycine metabolism (HP:0010895)3.59034533
32Abnormality of serine family amino acid metabolism (HP:0010894)3.59034533
33Hyperglycinuria (HP:0003108)3.58867218
34Hyperbilirubinemia (HP:0002904)3.27461281
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16641136
36Abnormality of fatty-acid metabolism (HP:0004359)3.11660929
37Steatorrhea (HP:0002570)3.10459616
38Abnormality of nucleobase metabolism (HP:0010932)3.06393648
39Ketoacidosis (HP:0001993)2.96588767
40Myocardial infarction (HP:0001658)2.92290436
41Hypochromic microcytic anemia (HP:0004840)2.90578819
42Systemic lupus erythematosus (HP:0002725)2.90567940
43Abnormality of serum amino acid levels (HP:0003112)2.88745046
44Hepatocellular carcinoma (HP:0001402)2.84312934
45Amyloidosis (HP:0011034)2.81776757
46Glomerulonephritis (HP:0000099)2.80863444
47Delayed CNS myelination (HP:0002188)2.79682285
48Skin nodule (HP:0200036)2.76419393
49Gingival bleeding (HP:0000225)2.75782891
50Osteomalacia (HP:0002749)2.75589704
51Hypoglycemic seizures (HP:0002173)2.70443166
52Abnormality of purine metabolism (HP:0004352)2.62966337
53Vascular calcification (HP:0004934)2.59753364
54Metabolic acidosis (HP:0001942)2.59595551
55Lethargy (HP:0001254)2.55534373
56Acanthocytosis (HP:0001927)2.54594209
57Cholecystitis (HP:0001082)2.53121473
58Abnormal gallbladder physiology (HP:0012438)2.53121473
59Recurrent gram-negative bacterial infections (HP:0005420)2.51575649
60Mitral stenosis (HP:0001718)2.50674703
61Abnormal gallbladder morphology (HP:0012437)2.44159013
62Cerebral edema (HP:0002181)2.43057003
63Spastic diplegia (HP:0001264)2.42179207
64Late onset (HP:0003584)2.40946062
65Cholelithiasis (HP:0001081)2.40213128
66Abnormality of iron homeostasis (HP:0011031)2.38998231
67Irritability (HP:0000737)2.35002411
68Purpura (HP:0000979)2.34415046
69Dicarboxylic aciduria (HP:0003215)2.33550857
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33550857
71Fair hair (HP:0002286)2.32831423
72Thrombophlebitis (HP:0004418)2.32785410
73Neonatal onset (HP:0003623)2.32361752
74Cardiovascular calcification (HP:0011915)2.30566501
75Abnormality of transition element cation homeostasis (HP:0011030)2.28302598
76Gout (HP:0001997)2.26342457
77Abnormal delivery (HP:0001787)2.26166753
78Menorrhagia (HP:0000132)2.25560568
79Neonatal hypoglycemia (HP:0001998)2.25363731
80Esophageal varix (HP:0002040)2.24574040
81Hyperinsulinemic hypoglycemia (HP:0000825)2.23393495
82Pulmonary embolism (HP:0002204)2.19172069
83Malnutrition (HP:0004395)2.11478560
84Reduced antithrombin III activity (HP:0001976)2.10403324
85Epistaxis (HP:0000421)2.07724094
86Retinal atrophy (HP:0001105)2.07540206
87Brushfield spots (HP:0001088)2.07396142
88Pancreatitis (HP:0001733)2.06899889
89Sensorimotor neuropathy (HP:0007141)2.05502127
90Increased serum ferritin (HP:0003281)2.02064064
91Nephritis (HP:0000123)2.01950751
92Elevated alkaline phosphatase (HP:0003155)2.01568825
93Poikilocytosis (HP:0004447)2.01206960
94Vomiting (HP:0002013)2.01059534
95Enlarged kidneys (HP:0000105)2.00632331
96Opisthotonus (HP:0002179)1.99194446
97Abnormality of the gallbladder (HP:0005264)1.97518793
98Glycosuria (HP:0003076)1.96856220
99Abnormality of urine glucose concentration (HP:0011016)1.96856220
100Hyperphosphaturia (HP:0003109)1.95520539
101Arthropathy (HP:0003040)1.94921749
102Hemorrhage of the eye (HP:0011885)1.94006960
103Abnormality of the Achilles tendon (HP:0005109)1.89111068
104Rickets (HP:0002748)1.88152535
105Hyperglycemia (HP:0003074)1.87602344
106Abnormality of alkaline phosphatase activity (HP:0004379)1.87179024
107Abnormality of vitamin metabolism (HP:0100508)1.87059715
108Generalized aminoaciduria (HP:0002909)1.82264803
109Hypophosphatemic rickets (HP:0004912)1.81056926
110Abnormal cartilage morphology (HP:0002763)1.79932344
111Alkalosis (HP:0001948)1.78863954
112Symptomatic seizures (HP:0011145)1.74651708
113Elevated hepatic transaminases (HP:0002910)1.73739410
114Joint swelling (HP:0001386)1.73205244
115Abnormal enzyme/coenzyme activity (HP:0012379)1.73076762
116Status epilepticus (HP:0002133)1.71245913
117Reticulocytosis (HP:0001923)1.67272077
118Hypertriglyceridemia (HP:0002155)1.67055344
119Gangrene (HP:0100758)1.64612898
120Cerebral palsy (HP:0100021)1.64260357
121Generalized hypopigmentation of hair (HP:0011358)1.57966363
122Atrioventricular block (HP:0001678)1.56935006
123Abnormal urine phosphate concentration (HP:0012599)1.56811136
124Increased serum pyruvate (HP:0003542)1.53598389
125Bifid scrotum (HP:0000048)1.52169574
126Increased mean platelet volume (HP:0011877)1.49725151
127Abnormal biliary tract physiology (HP:0012439)1.48452808
128Bile duct proliferation (HP:0001408)1.48452808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.90317276
2ERN14.87867308
3PDK24.81743041
4FGFR44.68468647
5SIK14.23902379
6TAOK33.42708694
7ERBB43.16105287
8INSRR2.79729923
9DAPK22.30477945
10MAP2K42.28607258
11MST1R2.12742017
12PIK3CG2.06932870
13NTRK31.95362127
14MAPK111.91869184
15TRIB31.82472405
16PKN21.77353747
17TYK21.69292828
18LMTK21.62904932
19FLT31.60856542
20PTK61.57858838
21LATS11.48264525
22TESK21.47814909
23NEK91.44740101
24ABL21.44285188
25MAP3K121.37655972
26PRPF4B1.35020312
27FRK1.34427555
28JAK21.26114511
29KDR1.25080533
30MAP3K21.24396407
31EPHB11.19749178
32FGFR21.18770620
33EPHA31.14639265
34TBK11.12946567
35ERBB21.12892972
36FER1.12800585
37PBK1.12561838
38NLK1.10558905
39GRK61.09859033
40MAP3K71.08732703
41JAK11.05295618
42PRKAA21.05209617
43SCYL21.00250663
44MAPK40.96537960
45ACVR1B0.95459272
46MAP3K140.95027301
47MAP2K30.94360884
48MAP3K110.91323255
49PRKG10.89156228
50CAMK2G0.88964474
51MET0.88738486
52PINK10.88416108
53PRKCZ0.86429451
54CASK0.85097061
55MAPK120.84727514
56MAP3K30.84493834
57AKT30.83364839
58WNK30.82988452
59MYLK0.82790804
60TNK20.82020799
61PRKACG0.81635815
62CAMK1D0.80752424
63RIPK10.80302084
64MUSK0.78836137
65MAP3K100.77759253
66DYRK1B0.74932198
67PRKACA0.73720058
68CSNK1D0.73404557
69CDK60.70800331
70TIE10.66045188
71MAPK150.66026909
72CSK0.65564167
73PIK3CA0.65516608
74MAP2K60.64713727
75GSK3A0.64340524
76PDGFRA0.64029318
77STK38L0.63037257
78PRKCB0.61875905
79MAP2K10.61830449
80IKBKE0.59056828
81CSF1R0.57060395
82FGFR30.56961831
83EPHA40.55580628
84PTK20.55059389
85PRKAA10.54408943
86MAPK70.53326177
87CSNK1E0.53018079
88TGFBR20.52841098
89SGK30.52006620
90PRKG20.51426305
91PDPK10.51090786
92PKN10.50588601
93ZAP700.50056395
94IGF1R0.45418086
95PRKCQ0.45381382
96PRKCG0.44972368
97CSNK2A10.43824055
98MAP3K130.43190854
99RPS6KA30.41776302
100ICK0.41638058
101SRC0.41361505
102CSNK1G10.41325242
103CAMK40.40706545
104CSNK1A10.40617849
105MAP3K50.40398307
106EGFR0.40290396
107MTOR0.39264227
108RET0.37919350
109CSNK2A20.37773409
110STK380.36933006
111TAOK20.36694140
112BLK0.36382111
113IRAK30.35421119
114KSR20.35282981
115SGK10.35116292
116SGK20.34759118
117CDK40.34430798
118MAP3K60.34104932
119NEK60.32786981
120GRK10.32502806
121MAP3K10.31293262
122PDK10.30983440
123PAK30.30038297
124CAMK1G0.29255446
125PRKACB0.28329675
126PRKCA0.28053296
127BMX0.27885959
128EPHA20.27227654
129SGK2230.25888180
130SGK4940.25888180
131LATS20.25815102
132CSNK1G20.23431326
133CSNK1G30.22989536
134IRAK10.22547577
135MAPK30.20459576
136ABL10.19240816

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53281549
2Nitrogen metabolism_Homo sapiens_hsa009103.58956714
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.49997403
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26675173
5Arginine biosynthesis_Homo sapiens_hsa002203.19112107
6Complement and coagulation cascades_Homo sapiens_hsa046103.04847724
7Tryptophan metabolism_Homo sapiens_hsa003802.65412847
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61116334
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56217760
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52864479
11Fatty acid degradation_Homo sapiens_hsa000712.36658260
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29356885
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27169269
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18112197
15Chemical carcinogenesis_Homo sapiens_hsa052042.08545066
16Peroxisome_Homo sapiens_hsa041462.04773323
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03565975
18Butanoate metabolism_Homo sapiens_hsa006502.03515751
19Staphylococcus aureus infection_Homo sapiens_hsa051501.96597208
20PPAR signaling pathway_Homo sapiens_hsa033201.87259034
21Histidine metabolism_Homo sapiens_hsa003401.86183169
22Propanoate metabolism_Homo sapiens_hsa006401.83574872
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.80409068
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75192959
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.72373472
26Fatty acid metabolism_Homo sapiens_hsa012121.72286903
27Caffeine metabolism_Homo sapiens_hsa002321.70642392
28beta-Alanine metabolism_Homo sapiens_hsa004101.62876027
29Retinol metabolism_Homo sapiens_hsa008301.61543141
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59019683
31Phenylalanine metabolism_Homo sapiens_hsa003601.58504748
32Selenocompound metabolism_Homo sapiens_hsa004501.55683591
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50830847
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48884080
35Bile secretion_Homo sapiens_hsa049761.47946446
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46152345
37Tyrosine metabolism_Homo sapiens_hsa003501.43060052
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.36469081
39Pyruvate metabolism_Homo sapiens_hsa006201.31600710
40Starch and sucrose metabolism_Homo sapiens_hsa005001.29612991
41Fat digestion and absorption_Homo sapiens_hsa049751.28033725
42Sulfur metabolism_Homo sapiens_hsa009201.27303143
43Folate biosynthesis_Homo sapiens_hsa007901.26513561
44Biosynthesis of amino acids_Homo sapiens_hsa012301.24747943
45Fatty acid elongation_Homo sapiens_hsa000621.22513284
46ABC transporters_Homo sapiens_hsa020101.21727279
47Steroid biosynthesis_Homo sapiens_hsa001001.21263292
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.13008323
49Carbon metabolism_Homo sapiens_hsa012001.12260160
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02758744
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.00277108
52Vitamin B6 metabolism_Homo sapiens_hsa007500.97966237
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97642899
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95601063
55Arginine and proline metabolism_Homo sapiens_hsa003300.95313032
56Vitamin digestion and absorption_Homo sapiens_hsa049770.91130694
57Sulfur relay system_Homo sapiens_hsa041220.91084772
58Glutathione metabolism_Homo sapiens_hsa004800.83352977
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80526975
60Lysine degradation_Homo sapiens_hsa003100.75401502
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74242071
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73144837
63One carbon pool by folate_Homo sapiens_hsa006700.69698038
64Glycerolipid metabolism_Homo sapiens_hsa005610.63728244
65Pentose phosphate pathway_Homo sapiens_hsa000300.63197271
66Fatty acid biosynthesis_Homo sapiens_hsa000610.49898646
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45902008
68Metabolic pathways_Homo sapiens_hsa011000.43942881
69Prion diseases_Homo sapiens_hsa050200.40536558
70Fructose and mannose metabolism_Homo sapiens_hsa000510.30506406
71Galactose metabolism_Homo sapiens_hsa000520.28139417
72Other glycan degradation_Homo sapiens_hsa005110.27276245
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21846129
74Insulin resistance_Homo sapiens_hsa049310.21722371
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.21528371
76Linoleic acid metabolism_Homo sapiens_hsa005910.15600066
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15272773
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.13718038
79Glucagon signaling pathway_Homo sapiens_hsa049220.11573447
80AMPK signaling pathway_Homo sapiens_hsa041520.01779902
81Mineral absorption_Homo sapiens_hsa049780.01253400
82Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2546418
83Type II diabetes mellitus_Homo sapiens_hsa04930-0.2523271
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2492365
85ECM-receptor interaction_Homo sapiens_hsa04512-0.2416238
86Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2369003
87Circadian rhythm_Homo sapiens_hsa04710-0.2326764
88Amoebiasis_Homo sapiens_hsa05146-0.2215689
89Pertussis_Homo sapiens_hsa05133-0.2206944
90Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2078371
91Bladder cancer_Homo sapiens_hsa05219-0.1829855
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1792821
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1773281
94Regulation of autophagy_Homo sapiens_hsa04140-0.1732375
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1688585
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1637894
97N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1562156
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1561925
99Hepatitis C_Homo sapiens_hsa05160-0.1549093
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1544382
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1220728
102African trypanosomiasis_Homo sapiens_hsa05143-0.1145754
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1139064
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1103813
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1032708
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0960445
107Serotonergic synapse_Homo sapiens_hsa04726-0.0597840
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0450326
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0335350
110Sphingolipid metabolism_Homo sapiens_hsa00600-0.0294463

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