HR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.30015076
2desmosome organization (GO:0002934)9.05524423
3hemidesmosome assembly (GO:0031581)8.24415717
4establishment of skin barrier (GO:0061436)7.59997505
5regulation of water loss via skin (GO:0033561)6.75395704
6peptide cross-linking (GO:0018149)5.55798755
7intermediate filament organization (GO:0045109)5.27037439
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.77507249
9multicellular organismal water homeostasis (GO:0050891)4.56981245
10keratinocyte differentiation (GO:0030216)4.49505370
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.46756526
12glutamate secretion (GO:0014047)4.19374659
13epidermis development (GO:0008544)3.98368934
14epithelial cell differentiation involved in prostate gland development (GO:0060742)3.88014237
15skin morphogenesis (GO:0043589)3.79894611
16sodium ion export (GO:0071436)3.71978293
17water homeostasis (GO:0030104)3.68003022
18virion attachment to host cell (GO:0019062)3.67859828
19adhesion of symbiont to host cell (GO:0044650)3.67859828
20plasma membrane repair (GO:0001778)3.66067133
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.54089512
22cell-substrate junction assembly (GO:0007044)3.53048987
23epidermal cell differentiation (GO:0009913)3.52258332
24activation of Rac GTPase activity (GO:0032863)3.51602124
25cell communication involved in cardiac conduction (GO:0086065)3.45739249
26regulation of skeletal muscle contraction (GO:0014819)3.44683486
27cellular potassium ion homeostasis (GO:0030007)3.36666623
28synaptic vesicle exocytosis (GO:0016079)3.30856298
29intermediate filament cytoskeleton organization (GO:0045104)3.29298915
30ectoderm development (GO:0007398)3.29017143
31polarized epithelial cell differentiation (GO:0030859)3.27565379
32ventricular cardiac muscle cell action potential (GO:0086005)3.26579898
33positive regulation of synapse maturation (GO:0090129)3.25564089
34negative regulation of keratinocyte proliferation (GO:0010839)3.22819387
35positive regulation of epidermal cell differentiation (GO:0045606)3.21815612
36intermediate filament-based process (GO:0045103)3.19986675
37establishment of planar polarity (GO:0001736)3.19625934
38establishment of tissue polarity (GO:0007164)3.19625934
39actin-myosin filament sliding (GO:0033275)3.18469130
40muscle filament sliding (GO:0030049)3.18469130
41keratinocyte proliferation (GO:0043616)3.11753951
42peptidyl-tyrosine autophosphorylation (GO:0038083)3.09388560
43gap junction assembly (GO:0016264)3.09357286
44protein localization to endosome (GO:0036010)3.05807678
45positive regulation of epidermis development (GO:0045684)3.04519047
46positive regulation of keratinocyte differentiation (GO:0045618)3.02777204
47regulation of heart rate by cardiac conduction (GO:0086091)3.00339415
48adhesion of symbiont to host (GO:0044406)2.94741020
49adherens junction assembly (GO:0034333)2.94583869
50skin development (GO:0043588)2.92840048
51dendritic spine organization (GO:0097061)2.92599528
52semaphorin-plexin signaling pathway (GO:0071526)2.88537554
53focal adhesion assembly (GO:0048041)2.87186585
54cell-substrate adherens junction assembly (GO:0007045)2.87186585
55skeletal muscle adaptation (GO:0043501)2.86546944
56negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.85333606
57potassium ion homeostasis (GO:0055075)2.80139929
58potassium ion import (GO:0010107)2.78492442
59regulation of keratinocyte differentiation (GO:0045616)2.77523741
60atrioventricular valve morphogenesis (GO:0003181)2.75958308
61cerebellar granule cell differentiation (GO:0021707)2.75704896
62cardiac conduction (GO:0061337)2.74279740
63actin-mediated cell contraction (GO:0070252)2.68763370
64regulation of skeletal muscle cell differentiation (GO:2001014)2.68665274
65amino acid import (GO:0043090)2.68008991
66mitotic G1 DNA damage checkpoint (GO:0031571)2.67457615
67sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65359830
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.63057622
69linoleic acid metabolic process (GO:0043651)2.62749439
70myelin maintenance (GO:0043217)2.61871453
71apical protein localization (GO:0045176)2.60796825
72regulation of synaptic vesicle exocytosis (GO:2000300)2.60690859
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57972203
74positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56995727
75surfactant homeostasis (GO:0043129)2.55852081
76long-chain fatty acid biosynthetic process (GO:0042759)2.55686808
77regulation of ARF protein signal transduction (GO:0032012)2.54612229
78epithelial cell-cell adhesion (GO:0090136)2.54402763
79regulation of early endosome to late endosome transport (GO:2000641)2.54387027
80cardiac muscle cell action potential involved in contraction (GO:0086002)2.54105691
81synaptic vesicle maturation (GO:0016188)2.53909576
82cardiac muscle cell action potential (GO:0086001)2.53403451
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53311869
84regulation of neuronal synaptic plasticity (GO:0048168)2.50705101
85Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50590536
86G1 DNA damage checkpoint (GO:0044783)2.46325913
87locomotory exploration behavior (GO:0035641)2.45106496
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.44641185
89establishment of protein localization to plasma membrane (GO:0090002)2.43310333
90negative regulation of cell fate specification (GO:0009996)2.43193124
91protein retention in ER lumen (GO:0006621)2.42503514
92regulation of keratinocyte proliferation (GO:0010837)2.41384863
93regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.41178659
94morphogenesis of embryonic epithelium (GO:0016331)2.41072696
95positive regulation of sodium ion transmembrane transport (GO:1902307)2.40887071
96neurotransmitter secretion (GO:0007269)2.40842461
97planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40682981
98regulation of cardioblast differentiation (GO:0051890)2.40010171
99branching involved in mammary gland duct morphogenesis (GO:0060444)2.38256880
100neuronal ion channel clustering (GO:0045161)2.36967389
101regulation of short-term neuronal synaptic plasticity (GO:0048172)2.36063858
102hair follicle morphogenesis (GO:0031069)2.35084184
103cell junction assembly (GO:0034329)2.34700086
104regulation of establishment of planar polarity (GO:0090175)2.34688926
105cell communication by electrical coupling (GO:0010644)2.34641724
106regulation of epidermis development (GO:0045682)2.34617046
107endothelial cell chemotaxis (GO:0035767)2.34255055
108negative regulation of catenin import into nucleus (GO:0035414)2.33848184
109keratinocyte development (GO:0003334)2.33795556
110regulation of clathrin-mediated endocytosis (GO:2000369)2.33202555
111synaptic vesicle endocytosis (GO:0048488)2.32737853
112neuromuscular junction development (GO:0007528)2.32517986
113actin filament-based movement (GO:0030048)2.32301391
114COPI coating of Golgi vesicle (GO:0048205)2.32197618
115Golgi transport vesicle coating (GO:0048200)2.32197618
116sarcomere organization (GO:0045214)2.31928760
117cell-cell junction maintenance (GO:0045217)2.31498867
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.31049487
119asymmetric protein localization (GO:0008105)2.30856475
120cell-cell junction assembly (GO:0007043)2.29928878
121cell junction organization (GO:0034330)2.29811388
122skeletal muscle fiber development (GO:0048741)2.29427854
123cardiac muscle contraction (GO:0060048)2.29049941
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28856829
125striated muscle contraction (GO:0006941)2.28547368
126neuronal action potential propagation (GO:0019227)2.26993924
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25730591
128vocalization behavior (GO:0071625)2.25691885
129regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.25533449
130non-canonical Wnt signaling pathway (GO:0035567)2.25004059
131protein heterotrimerization (GO:0070208)2.23779382
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.23419080
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.22708587
134response to pheromone (GO:0019236)2.22350969
135skeletal muscle contraction (GO:0003009)2.21795661
136creatine metabolic process (GO:0006600)2.19667937
137layer formation in cerebral cortex (GO:0021819)2.19571187
138regulation of cell communication by electrical coupling (GO:0010649)2.16858247
139myofibril assembly (GO:0030239)2.15979322
140regulation of p38MAPK cascade (GO:1900744)2.15977958
141cerebellar Purkinje cell differentiation (GO:0021702)2.15874400
142cellular sodium ion homeostasis (GO:0006883)2.15645645
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.13214347
144regulation of voltage-gated calcium channel activity (GO:1901385)2.12485730
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.09556413
146peripheral nervous system axon ensheathment (GO:0032292)2.06340554
147myelination in peripheral nervous system (GO:0022011)2.06340554
148positive regulation of vesicle fusion (GO:0031340)2.06236942
149myotube differentiation (GO:0014902)2.05214170
150tooth mineralization (GO:0034505)2.04536183
151negative regulation of potassium ion transmembrane transport (GO:1901380)2.03967604
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.02809710
153regulation of synapse structural plasticity (GO:0051823)2.02537149
154regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.02360840
155molting cycle (GO:0042303)10.0520554
156hair cycle (GO:0042633)10.0520554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.89957672
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78047098
3ZNF263_19887448_ChIP-Seq_K562_Human2.12292837
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.03715334
5ESR2_21235772_ChIP-Seq_MCF-7_Human1.96581527
6P63_26484246_Chip-Seq_KERATINOCYTES_Human1.95089401
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86731135
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83346893
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82238333
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.81919805
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.81919805
12DROSHA_22980978_ChIP-Seq_HELA_Human1.80734357
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73316351
14* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72177668
15AR_21572438_ChIP-Seq_LNCaP_Human1.67857987
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67829803
17* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67677360
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65900152
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65471754
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65066538
21* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63077475
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62138574
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.58435054
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55301950
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.55235925
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.54600135
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.54388276
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.54043165
29* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52024950
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51212729
31KDM2B_26808549_Chip-Seq_K562_Human1.50318338
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48031448
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47440500
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.42447554
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40656886
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39647292
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38037877
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.35523140
39CREB1_26743006_Chip-Seq_LNCaP_Human1.35231827
40* TET1_21490601_ChIP-Seq_MESCs_Mouse1.34898108
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34557674
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33674222
43LXR_22292898_ChIP-Seq_THP-1_Human1.33296406
44CTCF_27219007_Chip-Seq_Bcells_Human1.33177765
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29123911
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28706061
47EZH2_22144423_ChIP-Seq_EOC_Human1.28553637
48TP63_22573176_ChIP-Seq_HFKS_Human1.28166976
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.26663150
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26494787
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26070315
52AHR_22903824_ChIP-Seq_MCF-7_Human1.23946282
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21425393
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.21154822
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20951367
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20394030
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20238285
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.19866018
59RACK7_27058665_Chip-Seq_MCF-7_Human1.19660152
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.18915096
61TCF7_22412390_ChIP-Seq_EML_Mouse1.18379316
62* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16321669
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15955721
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15731820
65RXR_22108803_ChIP-Seq_LS180_Human1.15108705
66KLF5_25053715_ChIP-Seq_YYC3_Human1.13567488
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.13481822
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12395012
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12020652
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11143263
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11137970
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10008510
73* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09776089
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.09423814
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08967373
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.08927721
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.08927721
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.08828862
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.08766881
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07862916
81* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07163275
82* RING1B_27294783_Chip-Seq_ESCs_Mouse1.06370522
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04834698
84KDM2B_26808549_Chip-Seq_DND41_Human1.04055755
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.03993315
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03678006
87CJUN_26792858_Chip-Seq_BT549_Human1.03390082
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.02795454
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02391710
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00839678
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00839678
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00371684
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.99008805
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98939100
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98767194
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98319487
97SMC4_20622854_ChIP-Seq_HELA_Human0.97816182
98TP63_23658742_ChIP-Seq_EP156T_Human0.97670421
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95671448
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95372916
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94795974
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94143400
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92863432
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92137978
105* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91435663
106BCOR_27268052_Chip-Seq_Bcells_Human0.90824057
107TP53_22127205_ChIP-Seq_IMR90_Human0.90433141
108CLOCK_20551151_ChIP-Seq_293T_Human0.90302648
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89917364
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89631119
111P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89337748
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.88936843
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88613888
114* TP53_23651856_ChIP-Seq_MEFs_Mouse0.87226489
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86884655
116RING1B_27294783_Chip-Seq_NPCs_Mouse0.86668013
117SOX2_20726797_ChIP-Seq_SW620_Human0.86455221
118TP53_16413492_ChIP-PET_HCT116_Human0.86140284
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84538054
120* P68_20966046_ChIP-Seq_HELA_Human0.84438166
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84430795
122ATF3_27146783_Chip-Seq_COLON_Human0.83991249
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.83576242
124* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82128302
125ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81794784
126CTCF_20526341_ChIP-Seq_ESCs_Human0.81419176
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.81389624
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81130276
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80434015
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80034632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.13998766
2MP0002796_impaired_skin_barrier5.96098112
3* MP0000579_abnormal_nail_morphology4.32501238
4MP0010234_abnormal_vibrissa_follicle3.74632652
5* MP0005501_abnormal_skin_physiology3.23685335
6MP0002254_reproductive_system_inflammat2.95565834
7MP0000383_abnormal_hair_follicle2.86573294
8MP0009379_abnormal_foot_pigmentation2.83871260
9MP0000751_myopathy2.76570607
10* MP0002060_abnormal_skin_morphology2.65888702
11MP0010678_abnormal_skin_adnexa2.61522721
12MP0001216_abnormal_epidermal_layer2.53234878
13* MP0000647_abnormal_sebaceous_gland2.50373448
14* MP0010771_integument_phenotype2.36741498
15MP0002234_abnormal_pharynx_morphology2.32982329
16* MP0002098_abnormal_vibrissa_morphology2.30804820
17MP0000467_abnormal_esophagus_morphology2.25188001
18MP0000377_abnormal_hair_follicle2.20161270
19MP0008438_abnormal_cutaneous_collagen2.03180627
20MP0000762_abnormal_tongue_morphology2.01541527
21MP0003453_abnormal_keratinocyte_physiol1.97506063
22MP0004145_abnormal_muscle_electrophysio1.94671898
23MP0000749_muscle_degeneration1.89271396
24MP0004185_abnormal_adipocyte_glucose1.87042256
25MP0003941_abnormal_skin_development1.80212265
26MP0004381_abnormal_hair_follicle1.76639912
27MP0004947_skin_inflammation1.75474791
28* MP0000427_abnormal_hair_cycle1.74627995
29MP0003566_abnormal_cell_adhesion1.72877070
30MP0002837_dystrophic_cardiac_calcinosis1.68071758
31MP0004264_abnormal_extraembryonic_tissu1.58967280
32MP0004859_abnormal_synaptic_plasticity1.49483009
33MP0001849_ear_inflammation1.48874450
34* MP0003705_abnormal_hypodermis_morpholog1.39364315
35MP0004130_abnormal_muscle_cell1.39188263
36MP0008569_lethality_at_weaning1.39008797
37MP0003646_muscle_fatigue1.38973980
38MP0005666_abnormal_adipose_tissue1.32179708
39MP0000747_muscle_weakness1.30917465
40MP0004087_abnormal_muscle_fiber1.30888496
41MP0004036_abnormal_muscle_relaxation1.29688370
42MP0005423_abnormal_somatic_nervous1.27649574
43MP0005076_abnormal_cell_differentiation1.26571659
44MP0004270_analgesia1.25893864
45MP0004858_abnormal_nervous_system1.24243123
46MP0004782_abnormal_surfactant_physiolog1.23980514
47MP0000750_abnormal_muscle_regeneration1.23950527
48MP0005375_adipose_tissue_phenotype1.21282132
49* MP0009931_abnormal_skin_appearance1.20793505
50MP0001348_abnormal_lacrimal_gland1.20342023
51MP0000759_abnormal_skeletal_muscle1.19518411
52* MP0001243_abnormal_dermal_layer1.14835124
53MP0002106_abnormal_muscle_physiology1.13696643
54MP0000367_abnormal_coat/_hair1.13069749
55MP0005620_abnormal_muscle_contractility1.11360780
56MP0003950_abnormal_plasma_membrane1.09997642
57MP0000013_abnormal_adipose_tissue1.07846345
58MP0004215_abnormal_myocardial_fiber1.06431596
59MP0001191_abnormal_skin_condition1.06148050
60MP0004084_abnormal_cardiac_muscle1.04115888
61MP0001346_abnormal_lacrimal_gland1.02001605
62MP0002249_abnormal_larynx_morphology1.00724714
63MP0005369_muscle_phenotype1.00701632
64MP0000015_abnormal_ear_pigmentation1.00469255
65MP0004885_abnormal_endolymph0.99722062
66MP0009046_muscle_twitch0.99396244
67MP0010352_gastrointestinal_tract_polyps0.98568910
68MP0002108_abnormal_muscle_morphology0.97442733
69MP0000003_abnormal_adipose_tissue0.97361130
70MP0005670_abnormal_white_adipose0.96581480
71MP0003045_fibrosis0.96385914
72MP0005409_darkened_coat_color0.96236793
73MP0005330_cardiomyopathy0.95946843
74MP0003880_abnormal_central_pattern0.95491959
75MP0005023_abnormal_wound_healing0.94515948
76MP0000537_abnormal_urethra_morphology0.93853047
77MP0000566_synostosis0.93751147
78MP0008260_abnormal_autophagy0.92664910
79MP0000462_abnormal_digestive_system0.92562810
80MP0008961_abnormal_basal_metabolism0.91688264
81MP0003011_delayed_dark_adaptation0.91687513
82MP0005171_absent_coat_pigmentation0.91007652
83MP0001299_abnormal_eye_distance/0.90273146
84MP0004272_abnormal_basement_membrane0.85674774
85MP0005075_abnormal_melanosome_morpholog0.85371898
86MP0002095_abnormal_skin_pigmentation0.85268095
87MP0000733_abnormal_muscle_development0.84978024
88MP0000678_abnormal_parathyroid_gland0.84396850
89MP0002089_abnormal_postnatal_growth/wei0.83766865
90MP0010030_abnormal_orbit_morphology0.83545353
91MP0003635_abnormal_synaptic_transmissio0.83418186
92MP0002269_muscular_atrophy0.82263933
93MP0002909_abnormal_adrenal_gland0.82217667
94MP0003879_abnormal_hair_cell0.81348307
95MP0002090_abnormal_vision0.81261100
96MP0002972_abnormal_cardiac_muscle0.80088081
97MP0005551_abnormal_eye_electrophysiolog0.79907764
98MP0003329_amyloid_beta_deposits0.76751390
99MP0002896_abnormal_bone_mineralization0.74940214
100MP0002064_seizures0.74258822
101MP0005503_abnormal_tendon_morphology0.70885514
102MP0003191_abnormal_cellular_cholesterol0.68619031
103MP0009053_abnormal_anal_canal0.68008384
104MP0001340_abnormal_eyelid_morphology0.67766313
105MP0003634_abnormal_glial_cell0.67627216
106MP0002063_abnormal_learning/memory/cond0.67301285
107MP0004233_abnormal_muscle_weight0.66616038
108* MP0000627_abnormal_mammary_gland0.65747097
109MP0005058_abnormal_lysosome_morphology0.65168830
110MP0005623_abnormal_meninges_morphology0.64843310
111MP0003137_abnormal_impulse_conducting0.64611800
112MP0004484_altered_response_of0.61573433
113MP0006138_congestive_heart_failure0.60888918
114MP0003183_abnormal_peptide_metabolism0.60333072
115MP0005451_abnormal_body_composition0.60298748
116MP0009780_abnormal_chondrocyte_physiolo0.59531511
117MP0002971_abnormal_brown_adipose0.58647337
118MP0001958_emphysema0.58566057
119MP0005174_abnormal_tail_pigmentation0.58407774
120MP0002877_abnormal_melanocyte_morpholog0.57367372
121MP0000920_abnormal_myelination0.55099911
122MP0010630_abnormal_cardiac_muscle0.54792780
123MP0001784_abnormal_fluid_regulation0.54294867
124MP0003123_paternal_imprinting0.54281996
125MP0002734_abnormal_mechanical_nocicepti0.53965626
126MP0005248_abnormal_Harderian_gland0.53400497
127MP0003755_abnormal_palate_morphology0.52849732
128MP0001177_atelectasis0.52756704
129MP0002332_abnormal_exercise_endurance0.51760201
130MP0001502_abnormal_circadian_rhythm0.51587764
131MP0001188_hyperpigmentation0.50250567
132MP0002272_abnormal_nervous_system0.49086231
133MP0005257_abnormal_intraocular_pressure0.49085110
134MP0001501_abnormal_sleep_pattern0.48992018
135MP0002177_abnormal_outer_ear0.48971441
136MP0005377_hearing/vestibular/ear_phenot0.47018284
137MP0003878_abnormal_ear_physiology0.47018284
138MP0001765_abnormal_ion_homeostasis0.46564241
139MP0002111_abnormal_tail_morphology0.45587859
140MP0003075_altered_response_to0.45303674
141MP0003115_abnormal_respiratory_system0.44014244
142MP0002572_abnormal_emotion/affect_behav0.41835951
143MP0003091_abnormal_cell_migration0.41444036

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)5.77289140
2* Hypotrichosis (HP:0001006)5.61496643
3Plantar hyperkeratosis (HP:0007556)5.42665142
4Onycholysis (HP:0001806)5.23629128
5Woolly hair (HP:0002224)5.20037237
6Right ventricular cardiomyopathy (HP:0011663)5.10804190
7Fragile nails (HP:0001808)5.08386366
8Abnormality of nail color (HP:0100643)5.06404664
9Palmoplantar hyperkeratosis (HP:0000972)4.80242069
10Increased IgE level (HP:0003212)4.61107205
11Thick nail (HP:0001805)4.51434848
12Palmar hyperkeratosis (HP:0010765)4.46137259
13Increased connective tissue (HP:0009025)4.32152687
14Atrophic scars (HP:0001075)4.30777633
15Type 1 muscle fiber predominance (HP:0003803)4.16586665
16Exercise-induced myalgia (HP:0003738)3.94523604
17Hyporeflexia of lower limbs (HP:0002600)3.86712087
18Nail dystrophy (HP:0008404)3.86237249
19Alopecia of scalp (HP:0002293)3.81272476
20Conjunctival hamartoma (HP:0100780)3.81228709
21Follicular hyperkeratosis (HP:0007502)3.72205000
22Muscle fiber splitting (HP:0003555)3.55908987
23Abnormality of the salivary glands (HP:0010286)3.36421239
24Ventricular tachycardia (HP:0004756)3.23357612
25Difficulty running (HP:0009046)3.19012883
26Round ear (HP:0100830)3.18946028
27Sudden death (HP:0001699)3.18559451
28Abnormal blistering of the skin (HP:0008066)3.17567298
29Fragile skin (HP:0001030)3.08165690
30Exercise-induced muscle cramps (HP:0003710)3.07886738
31* Abnormal hair laboratory examination (HP:0003328)3.07252126
32Muscle fiber inclusion bodies (HP:0100299)3.06749240
33Hamartoma of the eye (HP:0010568)3.03847847
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.00994183
35Erythema (HP:0010783)2.98586766
36Ventricular fibrillation (HP:0001663)2.93963415
37Abnormality of secondary sexual hair (HP:0009888)2.90541279
38Abnormality of the axillary hair (HP:0100134)2.90541279
39Increased variability in muscle fiber diameter (HP:0003557)2.89503083
40Abnormality of skeletal muscle fiber size (HP:0012084)2.73108981
41Sparse scalp hair (HP:0002209)2.67858553
42Absent eyelashes (HP:0000561)2.67286914
43Nemaline bodies (HP:0003798)2.64073920
44Mildly elevated creatine phosphokinase (HP:0008180)2.57874878
45Advanced eruption of teeth (HP:0006288)2.57042038
46Palmoplantar keratoderma (HP:0000982)2.55168785
47Distal lower limb muscle weakness (HP:0009053)2.54728671
48Myopathic facies (HP:0002058)2.53974871
49Hyperacusis (HP:0010780)2.53845953
50Abnormality of the neuromuscular junction (HP:0003398)2.52294891
51Fatigable weakness (HP:0003473)2.52294891
52Distal arthrogryposis (HP:0005684)2.52136943
53Ankyloglossia (HP:0010296)2.51380492
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51371995
55Erythroderma (HP:0001019)2.47996595
56Abnormality of the calf musculature (HP:0001430)2.39101088
57Neurofibrillary tangles (HP:0002185)2.36789341
58Achilles tendon contracture (HP:0001771)2.36368229
59Congenital ichthyosiform erythroderma (HP:0007431)2.35381418
60Selective tooth agenesis (HP:0001592)2.34674948
61Broad metatarsal (HP:0001783)2.34382577
62* Sparse eyelashes (HP:0000653)2.33241135
63Acanthosis nigricans (HP:0000956)2.32128870
64Myotonia (HP:0002486)2.30112703
65Muscle hypertrophy of the lower extremities (HP:0008968)2.28464870
66Spinal rigidity (HP:0003306)2.26400173
67Insomnia (HP:0100785)2.26229442
68Neck muscle weakness (HP:0000467)2.24691510
69Ridged nail (HP:0001807)2.23196133
70Cerebral inclusion bodies (HP:0100314)2.22409098
71Calf muscle hypertrophy (HP:0008981)2.21429108
72Premature rupture of membranes (HP:0001788)2.19878571
73* Pili torti (HP:0003777)2.19309233
74Aplasia cutis congenita (HP:0001057)2.17991486
75Difficulty climbing stairs (HP:0003551)2.17175363
76Pterygium (HP:0001059)2.16922795
77EMG: myopathic abnormalities (HP:0003458)2.15365885
78Distal lower limb amyotrophy (HP:0008944)2.13063489
79Curly hair (HP:0002212)2.12697254
80Broad face (HP:0000283)2.12280780
81Distal upper limb amyotrophy (HP:0007149)2.10697461
82Upper limb amyotrophy (HP:0009129)2.10697461
83Slow-growing hair (HP:0002217)2.05811652
84Abnormality of hair growth rate (HP:0011363)2.05811652
85Blepharitis (HP:0000498)2.05223356
86Oral leukoplakia (HP:0002745)2.04471346
87Shallow orbits (HP:0000586)2.04030773
88Abnormality of the Achilles tendon (HP:0005109)2.03844271
89Scapular winging (HP:0003691)2.03050836
90Myokymia (HP:0002411)2.01945903
91Myoglobinuria (HP:0002913)2.01070067
92Natal tooth (HP:0000695)1.99480518
93Aplasia involving bones of the upper limbs (HP:0009823)1.98199540
94Aplasia of the phalanges of the hand (HP:0009802)1.98199540
95Aplasia involving bones of the extremities (HP:0009825)1.98199540
96Supranuclear gaze palsy (HP:0000605)1.97494948
97Neonatal death (HP:0003811)1.96396666
98Ectropion (HP:0000656)1.96266233
99Septate vagina (HP:0001153)1.96012677
100Corneal erosion (HP:0200020)1.94789697
101Brittle hair (HP:0002299)1.93502451
102Nasolacrimal duct obstruction (HP:0000579)1.92507651
103Slender build (HP:0001533)1.91787284
104Muscle stiffness (HP:0003552)1.91623374
105Bladder diverticulum (HP:0000015)1.90485784
106Abnormality of oral frenula (HP:0000190)1.89676249
107Thin bony cortex (HP:0002753)1.88857593
108Hyperparathyroidism (HP:0000843)1.87521514
109Lip pit (HP:0100267)1.87038436
110Intention tremor (HP:0002080)1.85869662
111Ulnar deviation of the wrist (HP:0003049)1.84282189
112Ankle clonus (HP:0011448)1.84186195
113Lower limb amyotrophy (HP:0007210)1.82675427
114Congenital stationary night blindness (HP:0007642)1.82654751
115Abnormality of the distal phalanges of the toes (HP:0010182)1.81810344
116Abnormality of the gastric mucosa (HP:0004295)1.78395685
117Abnormality of permanent molar morphology (HP:0011071)1.76608183
118Abnormality of the dental root (HP:0006486)1.76608183
119Taurodontia (HP:0000679)1.76608183
120Ventricular arrhythmia (HP:0004308)1.75977875
121Frequent falls (HP:0002359)1.75785580
122Hypoplastic labia majora (HP:0000059)1.75164281
123Hypohidrosis (HP:0000966)1.74742272
124Parakeratosis (HP:0001036)1.69199846
125Popliteal pterygium (HP:0009756)1.69136876
126Abnormality of molar (HP:0011077)1.68727058
127Abnormality of molar morphology (HP:0011070)1.68727058
128Calcaneovalgus deformity (HP:0001848)1.68198972
129Split foot (HP:0001839)1.67506501
130Oligodontia (HP:0000677)1.67124894
131Ankle contracture (HP:0006466)1.67054611
132Action tremor (HP:0002345)1.66406196
133Hand muscle atrophy (HP:0009130)1.66129765
134Ulnar bowing (HP:0003031)1.65953584
135Anonychia (HP:0001798)1.65734826
136Cerebral aneurysm (HP:0004944)1.63030746
137Syncope (HP:0001279)1.61671037
138Germ cell neoplasia (HP:0100728)1.61483813
139Absent hair (HP:0002298)1.61246753
140Hypoplasia of dental enamel (HP:0006297)1.61226046
141Abnormality of the labia majora (HP:0012881)1.60418735
142Hamartoma (HP:0010566)1.60131162
143Malnutrition (HP:0004395)1.60043658
144Obstructive sleep apnea (HP:0002870)1.59763683
145Deformed tarsal bones (HP:0008119)1.58677181
146Bronchomalacia (HP:0002780)1.58501281
147Central scotoma (HP:0000603)1.56704882
148Laryngomalacia (HP:0001601)1.55682053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.46963076
2TTN3.34418737
3TRIB33.19272915
4PHKG22.66770674
5PHKG12.66770674
6FER2.45850731
7MAPKAPK32.30674841
8OBSCN2.26727335
9SMG12.07679003
10EPHB11.92960792
11MST1R1.88619399
12MAP3K91.83763507
13LATS11.81755662
14TAOK11.67803085
15DDR21.64255771
16MAP3K21.62767511
17ERN11.59706777
18SIK11.57970203
19TESK11.57471279
20MAP3K71.57187945
21DMPK1.54902684
22PAK61.54114581
23ARAF1.51031606
24MAP3K31.40433295
25STK381.38506297
26NEK61.38063929
27NTRK21.37883708
28EPHB21.37719668
29CDK121.35770216
30LMTK21.32046911
31NME11.31678787
32MAP2K41.27250247
33BMX1.19967842
34FGFR11.18729955
35DAPK21.16140782
36PRKD31.15071300
37PIK3CG1.14885390
38FGFR21.11623040
39PTK61.10538636
40KSR21.09460968
41ICK1.08497794
42LATS21.05490388
43EEF2K1.04451775
44MAP3K11.02875490
45CAMK1G0.98930100
46CAMKK10.98887563
47PINK10.98503718
48PDGFRA0.97787415
49IRAK30.97408915
50WNK10.96358163
51PKN20.96194260
52TYRO30.96007541
53NEK10.95276716
54NTRK10.94728048
55PRKD10.93394325
56RET0.90304080
57CAMK1D0.90038074
58NME20.89905525
59PRKCH0.89499464
60TRPM70.86312407
61MET0.86057643
62PAK40.85593178
63MTOR0.84791710
64PIK3CA0.83539668
65MUSK0.81248300
66TGFBR10.79674298
67UHMK10.79017895
68MAPK120.77545866
69MAP3K60.76866971
70RPS6KA20.75793800
71STK110.75469124
72CAMK2B0.73455166
73NTRK30.73045770
74PTK20.72326099
75MAPKAPK50.71134040
76EPHA20.71126483
77CAMK2G0.70581851
78EPHA30.69761320
79PBK0.68577938
80MAP2K60.67372166
81PRPF4B0.67204296
82MARK20.67147572
83MINK10.64429213
84ROCK20.63432609
85DAPK10.62689978
86PIM20.62150226
87MAP2K30.61977150
88MAP2K10.61361491
89MAP3K130.61119067
90PAK30.60632828
91CAMKK20.60444538
92FGFR30.59279634
93SCYL20.58923705
94ROCK10.57982396
95BRAF0.57356798
96CDK50.57320619
97PDK30.54824264
98PDK40.54824264
99PRKD20.54667058
100MARK10.54419565
101PKN10.52973909
102MAP2K20.52667676
103PRKG20.50546346
104CDC42BPA0.49344297
105CAMK10.48806715
106MAPK110.48790201
107PDPK10.48459234
108ERBB20.47748688
109PDGFRB0.47494491
110DYRK1B0.47189187
111CAMK40.47130730
112EPHA40.47049417
113MAP3K40.47019380
114SGK10.46357699
115PRKAA20.46082731
116SGK30.45981675
117RPS6KB10.45747943
118TNIK0.45339343
119FGFR40.44611187
120PRKCI0.44045242
121MAP3K110.43221493
122CDK190.42949957
123CDK150.41718756
124ALK0.41569382
125RPS6KB20.41553349
126SGK2230.40981278
127SGK4940.40981278
128GRK50.40163279
129IRAK20.39635502
130BCR0.39594951
131CDK180.38326549
132CAMK2D0.37140109
133CDK11A0.37120258
134PRKAA10.36900796
135TIE10.36543125
136MAPK100.35807682
137PAK20.31426339

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.25661055
2Phototransduction_Homo sapiens_hsa047441.99253804
3Dilated cardiomyopathy_Homo sapiens_hsa054141.89917799
4Cyanoamino acid metabolism_Homo sapiens_hsa004601.80373343
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74138371
6Gastric acid secretion_Homo sapiens_hsa049711.67495151
7Salivary secretion_Homo sapiens_hsa049701.63654345
8ECM-receptor interaction_Homo sapiens_hsa045121.61916070
9Circadian entrainment_Homo sapiens_hsa047131.56795201
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56541346
11Renin secretion_Homo sapiens_hsa049241.50177088
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50069908
13GnRH signaling pathway_Homo sapiens_hsa049121.48105517
14Oxytocin signaling pathway_Homo sapiens_hsa049211.46766933
15Synaptic vesicle cycle_Homo sapiens_hsa047211.46252867
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46164950
17Long-term potentiation_Homo sapiens_hsa047201.41124584
18Basal cell carcinoma_Homo sapiens_hsa052171.39641731
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38563159
20Fatty acid biosynthesis_Homo sapiens_hsa000611.35686528
21Glutamatergic synapse_Homo sapiens_hsa047241.34584958
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33856667
23Olfactory transduction_Homo sapiens_hsa047401.33662500
24Long-term depression_Homo sapiens_hsa047301.32110040
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25431382
26GABAergic synapse_Homo sapiens_hsa047271.24547312
27Histidine metabolism_Homo sapiens_hsa003401.23300097
28Calcium signaling pathway_Homo sapiens_hsa040201.22529606
29Nicotine addiction_Homo sapiens_hsa050331.21125621
30Arginine biosynthesis_Homo sapiens_hsa002201.17901023
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17769842
32Cardiac muscle contraction_Homo sapiens_hsa042601.17078318
33Melanogenesis_Homo sapiens_hsa049161.16530456
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.14129600
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13575133
36Focal adhesion_Homo sapiens_hsa045101.12270842
37Proteoglycans in cancer_Homo sapiens_hsa052051.12076835
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11390913
39Protein digestion and absorption_Homo sapiens_hsa049741.10642664
40VEGF signaling pathway_Homo sapiens_hsa043701.10447890
41Cholinergic synapse_Homo sapiens_hsa047251.10329576
42Hedgehog signaling pathway_Homo sapiens_hsa043401.08940624
43Thyroid cancer_Homo sapiens_hsa052161.08141377
44Vitamin B6 metabolism_Homo sapiens_hsa007501.08024350
45Amoebiasis_Homo sapiens_hsa051461.07602633
46Pancreatic secretion_Homo sapiens_hsa049721.07264837
47Axon guidance_Homo sapiens_hsa043601.07235749
48Dorso-ventral axis formation_Homo sapiens_hsa043201.06378035
49Insulin secretion_Homo sapiens_hsa049111.04730967
50Tight junction_Homo sapiens_hsa045301.04309730
51Estrogen signaling pathway_Homo sapiens_hsa049151.03208765
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02404556
53Sphingolipid metabolism_Homo sapiens_hsa006001.01632767
54Type II diabetes mellitus_Homo sapiens_hsa049301.00874468
55Bile secretion_Homo sapiens_hsa049760.99310598
56Glioma_Homo sapiens_hsa052140.98960753
57Ovarian steroidogenesis_Homo sapiens_hsa049130.98810185
58Nitrogen metabolism_Homo sapiens_hsa009100.98490033
59cAMP signaling pathway_Homo sapiens_hsa040240.98325083
60Morphine addiction_Homo sapiens_hsa050320.98217344
61Bladder cancer_Homo sapiens_hsa052190.97931042
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96944870
63Gap junction_Homo sapiens_hsa045400.95113042
64Dopaminergic synapse_Homo sapiens_hsa047280.94410359
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94017547
66Prion diseases_Homo sapiens_hsa050200.93639430
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.91663305
68Insulin resistance_Homo sapiens_hsa049310.91652345
69Vibrio cholerae infection_Homo sapiens_hsa051100.91330984
70Small cell lung cancer_Homo sapiens_hsa052220.90877724
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90448731
72Insulin signaling pathway_Homo sapiens_hsa049100.90177955
73Taste transduction_Homo sapiens_hsa047420.87381113
74Hippo signaling pathway_Homo sapiens_hsa043900.86578074
75Circadian rhythm_Homo sapiens_hsa047100.84662029
76Fructose and mannose metabolism_Homo sapiens_hsa000510.83310601
77ErbB signaling pathway_Homo sapiens_hsa040120.82618055
78Serotonergic synapse_Homo sapiens_hsa047260.81783089
79Amphetamine addiction_Homo sapiens_hsa050310.81093625
80Non-small cell lung cancer_Homo sapiens_hsa052230.80545701
81Phenylalanine metabolism_Homo sapiens_hsa003600.80078354
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.77756140
83Adherens junction_Homo sapiens_hsa045200.76184582
84Linoleic acid metabolism_Homo sapiens_hsa005910.76072232
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.75959350
86Chronic myeloid leukemia_Homo sapiens_hsa052200.75604048
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74846698
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73817000
89Glucagon signaling pathway_Homo sapiens_hsa049220.72276983
90PPAR signaling pathway_Homo sapiens_hsa033200.71435044
91Endometrial cancer_Homo sapiens_hsa052130.71309215
92MicroRNAs in cancer_Homo sapiens_hsa052060.71202285
93mTOR signaling pathway_Homo sapiens_hsa041500.70565919
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70077814
95Ether lipid metabolism_Homo sapiens_hsa005650.69677602
96Renal cell carcinoma_Homo sapiens_hsa052110.69503401
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68509515
98AMPK signaling pathway_Homo sapiens_hsa041520.67923080
99MAPK signaling pathway_Homo sapiens_hsa040100.66180106
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.65163428
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64032505
102Platelet activation_Homo sapiens_hsa046110.63923715
103Thyroid hormone synthesis_Homo sapiens_hsa049180.63883688
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63670715
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62830728
106Wnt signaling pathway_Homo sapiens_hsa043100.62727697
107Ras signaling pathway_Homo sapiens_hsa040140.62617491
108Acute myeloid leukemia_Homo sapiens_hsa052210.62501537
109Rap1 signaling pathway_Homo sapiens_hsa040150.62280080
110Fatty acid elongation_Homo sapiens_hsa000620.61828586
111Arginine and proline metabolism_Homo sapiens_hsa003300.61615461
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61389263
113Choline metabolism in cancer_Homo sapiens_hsa052310.60705578
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.59857951
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.58724599
116Notch signaling pathway_Homo sapiens_hsa043300.57896465
117Mineral absorption_Homo sapiens_hsa049780.57300206
118Endocytosis_Homo sapiens_hsa041440.57131536
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57114849
120Cocaine addiction_Homo sapiens_hsa050300.56607725
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55801661
122Inositol phosphate metabolism_Homo sapiens_hsa005620.55117936
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54499483
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53716079
125Fatty acid metabolism_Homo sapiens_hsa012120.52653845
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51414143

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