HRAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.21730477
2mammary gland epithelial cell proliferation (GO:0033598)5.83234351
3skin morphogenesis (GO:0043589)5.29735064
4substrate-dependent cell migration (GO:0006929)5.28963200
5cell adhesion mediated by integrin (GO:0033627)5.22299182
6vagina development (GO:0060068)5.20776317
7synaptic vesicle maturation (GO:0016188)5.13717988
8prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.07962861
9positive regulation of astrocyte differentiation (GO:0048711)5.03048321
10mesodermal cell differentiation (GO:0048333)4.99395589
11chondrocyte proliferation (GO:0035988)4.81960646
12uterus development (GO:0060065)4.67743780
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66817110
14endodermal cell differentiation (GO:0035987)4.60300134
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51203452
16protein localization to endosome (GO:0036010)4.45301709
17lung vasculature development (GO:0060426)4.42916000
18muscle cell migration (GO:0014812)4.41750660
19atrioventricular valve morphogenesis (GO:0003181)4.37736879
20female genitalia development (GO:0030540)4.35387808
21layer formation in cerebral cortex (GO:0021819)4.22639515
22protein retention in ER lumen (GO:0006621)4.15883534
23hypotonic response (GO:0006971)4.15544504
24vocalization behavior (GO:0071625)4.12369163
25locomotory exploration behavior (GO:0035641)4.05886383
26regulation of synapse structural plasticity (GO:0051823)4.04916391
27lung lobe morphogenesis (GO:0060463)4.01564436
28protein heterotrimerization (GO:0070208)4.01264559
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.96890478
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.92711688
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.92075508
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91662204
33regulation of response to osmotic stress (GO:0047484)3.90487414
34Golgi transport vesicle coating (GO:0048200)3.86624121
35COPI coating of Golgi vesicle (GO:0048205)3.86624121
36synaptic vesicle exocytosis (GO:0016079)3.86488751
37desmosome organization (GO:0002934)3.85153986
38mammary gland alveolus development (GO:0060749)3.84551244
39glutamate secretion (GO:0014047)3.82877625
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.82307957
41cerebellar Purkinje cell layer development (GO:0021680)3.80191680
42neuronal action potential propagation (GO:0019227)3.75874516
43activation of protein kinase A activity (GO:0034199)3.71085439
44regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.71049170
45positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.71049170
46branch elongation of an epithelium (GO:0060602)3.69220721
47branching involved in mammary gland duct morphogenesis (GO:0060444)3.66563077
48regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.59587683
49plasma membrane repair (GO:0001778)3.56325672
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56272285
51regulation of protein heterodimerization activity (GO:0043497)3.53339829
52protein maturation by protein folding (GO:0022417)3.49804543
53decidualization (GO:0046697)3.49009388
54regulation of glucocorticoid metabolic process (GO:0031943)3.47056239
55neurotransmitter secretion (GO:0007269)3.44423055
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.43839047
57branching involved in prostate gland morphogenesis (GO:0060442)3.41937539
58cell migration in hindbrain (GO:0021535)3.41714317
59regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.41127509
60regulation of glutamate receptor signaling pathway (GO:1900449)3.34412890
61protein localization to synapse (GO:0035418)3.33661809
62dendritic spine morphogenesis (GO:0060997)3.33622220
63regulation of early endosome to late endosome transport (GO:2000641)3.32223264
64mesenchymal-epithelial cell signaling (GO:0060638)3.31983767
65negative regulation of microtubule polymerization (GO:0031115)3.30757123
66positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.30161618
67regulation of synaptic vesicle exocytosis (GO:2000300)3.29601753
68negative regulation of axon extension involved in axon guidance (GO:0048843)3.27207828
69exploration behavior (GO:0035640)3.27180505
70basement membrane organization (GO:0071711)3.26469690
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26408203
72positive regulation of synapse maturation (GO:0090129)3.25326447
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.24592344
74* regulation of neuronal synaptic plasticity (GO:0048168)3.24263213
75positive regulation of blood vessel endothelial cell migration (GO:0043536)3.22554628
76viral transcription (GO:0019083)3.22120245
77positive regulation of nitric-oxide synthase activity (GO:0051000)3.21918611
78negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.18877103
79neuromuscular process controlling balance (GO:0050885)3.18736838
80type B pancreatic cell proliferation (GO:0044342)3.16509245
81molting cycle (GO:0042303)3.15212003
82hair cycle (GO:0042633)3.15212003
83sodium ion export (GO:0071436)3.12764943
84* regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12705540
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11970667
86dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11927182
87axon extension (GO:0048675)3.11707959
88muscle organ morphogenesis (GO:0048644)3.11334852
89regulation of dendritic spine morphogenesis (GO:0061001)3.09727854
90translational termination (GO:0006415)3.08433487
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07846975
92trophoblast giant cell differentiation (GO:0060707)3.07749853
93cell communication involved in cardiac conduction (GO:0086065)3.07747323
94regulation of mammary gland epithelial cell proliferation (GO:0033599)3.06785212
95heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.05947900
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04394154
97cell communication by electrical coupling (GO:0010644)3.02892979
98axis elongation (GO:0003401)3.01808224
99adhesion of symbiont to host cell (GO:0044650)3.01773747
100virion attachment to host cell (GO:0019062)3.01773747
101positive regulation of axon extension (GO:0045773)2.97619115
102fibrinolysis (GO:0042730)2.97268919
103hemidesmosome assembly (GO:0031581)2.97083890
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96359947
105regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.95901494
106collagen catabolic process (GO:0030574)2.95455716
107collagen metabolic process (GO:0032963)2.95014928
108establishment or maintenance of monopolar cell polarity (GO:0061339)2.92610314
109establishment of monopolar cell polarity (GO:0061162)2.92610314
110prepulse inhibition (GO:0060134)2.91037034
111long-term memory (GO:0007616)2.90871843
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90224194
113neuromuscular process controlling posture (GO:0050884)2.88948676
114intracellular estrogen receptor signaling pathway (GO:0030520)2.88559655
115regulation of synaptic vesicle transport (GO:1902803)2.88216718
116regulation of clathrin-mediated endocytosis (GO:2000369)2.87253099
117SMAD protein complex assembly (GO:0007183)2.86853757
118establishment of apical/basal cell polarity (GO:0035089)2.85993986
119adherens junction assembly (GO:0034333)2.82768055
120peptidyl-arginine omega-N-methylation (GO:0035247)2.81788681
121positive regulation of fibroblast migration (GO:0010763)2.80829216
122cellular response to vitamin D (GO:0071305)2.79845915
123negative regulation of cell size (GO:0045792)2.79171958
124regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.77082527
125vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.75255572
126adhesion of symbiont to host (GO:0044406)2.73602210
127positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.73582947
128positive regulation of vesicle fusion (GO:0031340)2.73273631
129dopamine receptor signaling pathway (GO:0007212)2.72255649
130translational elongation (GO:0006414)2.71563385
131positive regulation of neurotransmitter transport (GO:0051590)2.71282923
132neuron projection extension (GO:1990138)2.70904293
133bone trabecula formation (GO:0060346)2.69603270
134stress fiber assembly (GO:0043149)2.69170233
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67933838
136multicellular organismal macromolecule metabolic process (GO:0044259)2.66845859
137short-term memory (GO:0007614)2.66028621
138ephrin receptor signaling pathway (GO:0048013)2.65216951
139gamma-aminobutyric acid transport (GO:0015812)2.64519373
140maternal placenta development (GO:0001893)2.64516619
141positive regulation of neurotransmitter secretion (GO:0001956)2.63462174
142negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.61692145
143multicellular organismal catabolic process (GO:0044243)2.61611363
144barbed-end actin filament capping (GO:0051016)2.60244337
145semaphorin-plexin signaling pathway (GO:0071526)2.59434764
146protein hydroxylation (GO:0018126)2.59228788
147positive regulation of membrane potential (GO:0045838)2.59150942
148regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58592083
149N-glycan processing (GO:0006491)2.58494698
150ventricular trabecula myocardium morphogenesis (GO:0003222)2.58240190
151cellular potassium ion homeostasis (GO:0030007)2.57447304
152regulation of smooth muscle cell migration (GO:0014910)2.57447116
153cellular protein complex disassembly (GO:0043624)2.56882754
154positive regulation of p38MAPK cascade (GO:1900745)2.56320414
155regulation of female receptivity (GO:0045924)2.56248751
156peptidyl-proline hydroxylation (GO:0019511)2.56216497
157regulation of protein kinase A signaling (GO:0010738)2.55342413
158negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.55279838
159adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.55241587
160behavioral fear response (GO:0001662)2.53406744
161behavioral defense response (GO:0002209)2.53406744
162proline transport (GO:0015824)2.53357246
163heterochromatin organization (GO:0070828)2.53273625
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53242241
165positive regulation of osteoblast proliferation (GO:0033690)2.52672861
166positive regulation of monooxygenase activity (GO:0032770)2.52583694
167cellular response to vitamin (GO:0071295)2.52366495
168peptidyl-arginine N-methylation (GO:0035246)2.51937957
169peptidyl-arginine methylation (GO:0018216)2.51937957
170regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51306816
171glial cell migration (GO:0008347)2.50912356
172* regulation of synaptic plasticity (GO:0048167)2.49172642
173regulation of dendritic spine development (GO:0060998)2.47131683
174neurotransmitter-gated ion channel clustering (GO:0072578)2.46388610
175synaptic transmission, dopaminergic (GO:0001963)2.45534156
176intermediate filament organization (GO:0045109)2.45504079
177cell-substrate adherens junction assembly (GO:0007045)2.41651034
178focal adhesion assembly (GO:0048041)2.41651034
179neurotransmitter transport (GO:0006836)2.41544818
180regulation of excitatory postsynaptic membrane potential (GO:0060079)2.41438692
181regulation of neurotransmitter levels (GO:0001505)2.40607832
182ionotropic glutamate receptor signaling pathway (GO:0035235)2.40035568
183neuronal ion channel clustering (GO:0045161)2.39067848
184regulation of sodium ion transmembrane transporter activity (GO:2000649)2.38802947
185dendritic spine organization (GO:0097061)2.37739552
186mating behavior (GO:0007617)2.37650126
187keratinization (GO:0031424)2.36465632
188regulation of synaptic transmission, dopaminergic (GO:0032225)2.35741251
189neuromuscular process (GO:0050905)2.35486310
190behavioral response to cocaine (GO:0048148)2.35115523
191cell-substrate junction assembly (GO:0007044)2.34378704
192auditory behavior (GO:0031223)2.33828779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.02576990
2ZNF263_19887448_ChIP-Seq_K562_Human3.44039213
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87914629
4EZH2_22144423_ChIP-Seq_EOC_Human2.80529932
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.67553429
6ERG_21242973_ChIP-ChIP_JURKAT_Human2.65629809
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.63680415
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.56325014
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52122843
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.51314296
11* LXR_22292898_ChIP-Seq_THP-1_Human2.42636404
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39870157
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32952561
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05366523
15KDM2B_26808549_Chip-Seq_K562_Human1.99001504
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96890596
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96890596
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96709538
19DNAJC2_21179169_ChIP-ChIP_NT2_Human1.93944775
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.93346403
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92858299
22SRY_22984422_ChIP-ChIP_TESTIS_Rat1.92083936
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91746912
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91443939
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.90986947
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88195776
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84247217
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80084968
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.79397914
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78877226
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74158442
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73464742
33* CTCF_27219007_Chip-Seq_Bcells_Human1.72704785
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72577686
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72030740
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66481142
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65859443
38* KDM2B_26808549_Chip-Seq_DND41_Human1.65761706
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64493741
40VDR_21846776_ChIP-Seq_THP-1_Human1.63398081
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63328790
42CREB1_26743006_Chip-Seq_LNCaP_Human1.62939276
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.61404757
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60509054
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56787828
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.56522719
47ATF3_27146783_Chip-Seq_COLON_Human1.56447920
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.54470785
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.54173630
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54087312
51* UBF1/2_26484160_Chip-Seq_HMECs_Human1.52735869
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.52075317
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47287419
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45975395
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45225572
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41543534
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41303955
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39986123
59REST_21632747_ChIP-Seq_MESCs_Mouse1.38269644
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38263546
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37706326
62SMC4_20622854_ChIP-Seq_HELA_Human1.36841006
63* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36710925
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34351905
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33369482
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.32261865
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32261262
68SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.32248634
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31788966
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31777326
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31365000
72* KDM2B_26808549_Chip-Seq_JURKAT_Human1.31120221
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.31039795
74* P68_20966046_ChIP-Seq_HELA_Human1.30547025
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.30094295
76SMC3_22415368_ChIP-Seq_MEFs_Mouse1.29171702
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.28831183
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28693749
79DROSHA_22980978_ChIP-Seq_HELA_Human1.28439469
80* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27918671
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26732449
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.26289773
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26217541
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25268375
85CLOCK_20551151_ChIP-Seq_293T_Human1.25000074
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24465098
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23297901
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22396813
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21895201
90* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21184585
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.21107624
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.20951130
93* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19070026
94TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18605251
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18064125
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16920979
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15717653
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.14774662
99* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14498878
100* ELF1_20517297_ChIP-Seq_JURKAT_Human1.14279515
101* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13167336
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12917407
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12703014
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11376136
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10724808
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10479021
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08225453
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07086861
109* TP63_22573176_ChIP-Seq_HFKS_Human1.06855504
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06803777
111SA1_27219007_Chip-Seq_Bcells_Human1.06032124
112TET1_21490601_ChIP-Seq_MESCs_Mouse1.05876055
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05856979
114TCF7_22412390_ChIP-Seq_EML_Mouse1.05022263
115OCT4_19829295_ChIP-Seq_ESCs_Human1.04401230
116MYC_22102868_ChIP-Seq_BL_Human1.04011593
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03451970
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.03068653
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02566553
120BCOR_27268052_Chip-Seq_Bcells_Human1.01665591
121KLF4_19829295_ChIP-Seq_ESCs_Human1.01652597
122TP53_22127205_ChIP-Seq_IMR90_Human1.00502119
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00367839
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00097474
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00097474
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99967140
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.98984732
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98432498
129MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98215842
130* ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97852276
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97660046
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95648005
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95411863
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94819820
135CTCF_20526341_ChIP-Seq_ESCs_Human0.94608780
136CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94564283
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94204390
138CTCF_21964334_Chip-Seq_Bcells_Human0.94012324
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93579826
140TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91284540
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91279489
142ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88978356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53616605
2MP0008438_abnormal_cutaneous_collagen3.85591283
3MP0002822_catalepsy3.46354209
4MP0001542_abnormal_bone_strength3.34818041
5MP0010234_abnormal_vibrissa_follicle3.31642494
6MP0002796_impaired_skin_barrier3.14053516
7MP0004270_analgesia3.04338321
8MP0003635_abnormal_synaptic_transmissio2.98685082
9MP0003705_abnormal_hypodermis_morpholog2.86102245
10MP0003880_abnormal_central_pattern2.73997769
11MP0001727_abnormal_embryo_implantation2.61584575
12MP0001968_abnormal_touch/_nociception2.36230218
13MP0005257_abnormal_intraocular_pressure2.35469619
14MP0002063_abnormal_learning/memory/cond2.31219536
15MP0002877_abnormal_melanocyte_morpholog2.28615410
16MP0000751_myopathy2.26333975
17MP0004272_abnormal_basement_membrane2.26223156
18MP0004858_abnormal_nervous_system2.25253749
19MP0003279_aneurysm2.23587414
20MP0001986_abnormal_taste_sensitivity2.21616774
21MP0009379_abnormal_foot_pigmentation2.20654166
22MP0005451_abnormal_body_composition2.16398225
23MP0009745_abnormal_behavioral_response2.15557995
24MP0005275_abnormal_skin_tensile2.10190125
25MP0002064_seizures1.87595349
26MP0000579_abnormal_nail_morphology1.87535253
27MP0010307_abnormal_tumor_latency1.86116377
28MP0001299_abnormal_eye_distance/1.85135870
29MP0002909_abnormal_adrenal_gland1.84896656
30MP0003329_amyloid_beta_deposits1.84284080
31MP0005501_abnormal_skin_physiology1.82033707
32MP0004185_abnormal_adipocyte_glucose1.78419422
33MP0002734_abnormal_mechanical_nocicepti1.76898868
34MP0002733_abnormal_thermal_nociception1.64816133
35MP0002736_abnormal_nociception_after1.64815119
36MP0004145_abnormal_muscle_electrophysio1.62994017
37MP0003315_abnormal_perineum_morphology1.60166036
38MP0003941_abnormal_skin_development1.59931705
39MP0002572_abnormal_emotion/affect_behav1.56610424
40MP0005623_abnormal_meninges_morphology1.53089550
41MP0004510_myositis1.51100795
42MP0001970_abnormal_pain_threshold1.50201591
43MP0002896_abnormal_bone_mineralization1.48144739
44MP0003091_abnormal_cell_migration1.47345344
45MP0002837_dystrophic_cardiac_calcinosis1.46256366
46MP0004811_abnormal_neuron_physiology1.46186104
47MP0000747_muscle_weakness1.44676246
48MP0005646_abnormal_pituitary_gland1.44451391
49MP0003123_paternal_imprinting1.43046869
50MP0002089_abnormal_postnatal_growth/wei1.40099617
51MP0009840_abnormal_foam_cell1.39648532
52MP0009053_abnormal_anal_canal1.39382389
53MP0002735_abnormal_chemical_nociception1.39254224
54MP0009046_muscle_twitch1.39133286
55MP0000858_altered_metastatic_potential1.35721613
56MP0002177_abnormal_outer_ear1.35093416
57MP0010030_abnormal_orbit_morphology1.34437432
58MP0002295_abnormal_pulmonary_circulatio1.34000276
59MP0000733_abnormal_muscle_development1.33828795
60MP0001440_abnormal_grooming_behavior1.33163377
61MP0000627_abnormal_mammary_gland1.31990009
62MP0005058_abnormal_lysosome_morphology1.28396375
63MP0010368_abnormal_lymphatic_system1.28006198
64MP0010771_integument_phenotype1.27505252
65MP0008995_early_reproductive_senescence1.24737941
66MP0008961_abnormal_basal_metabolism1.24613524
67MP0002160_abnormal_reproductive_system1.23420829
68MP0005023_abnormal_wound_healing1.23403493
69MP0000750_abnormal_muscle_regeneration1.23396785
70MP0002272_abnormal_nervous_system1.22909580
71MP0002184_abnormal_innervation1.20063760
72MP0001958_emphysema1.19659212
73MP0002060_abnormal_skin_morphology1.19597967
74MP0002234_abnormal_pharynx_morphology1.18831503
75MP0000955_abnormal_spinal_cord1.18211124
76MP0000749_muscle_degeneration1.16641238
77MP0003303_peritoneal_inflammation1.15294458
78MP0003646_muscle_fatigue1.13617329
79MP0001881_abnormal_mammary_gland1.13169455
80MP0000759_abnormal_skeletal_muscle1.12511343
81MP0009780_abnormal_chondrocyte_physiolo1.11167071
82MP0000467_abnormal_esophagus_morphology1.09339894
83MP0003879_abnormal_hair_cell1.08963152
84MP0001849_ear_inflammation1.08614053
85MP0004087_abnormal_muscle_fiber1.07335235
86MP0005166_decreased_susceptibility_to1.06844325
87MP0005197_abnormal_uvea_morphology1.05916773
88MP0004130_abnormal_muscle_cell1.04911226
89MP0001905_abnormal_dopamine_level1.04610294
90MP0000537_abnormal_urethra_morphology1.03356893
91MP0009250_abnormal_appendicular_skeleto1.02871197
92MP0005330_cardiomyopathy1.02709094
93MP0005164_abnormal_response_to1.01094668
94MP0005508_abnormal_skeleton_morphology1.00852365
95MP0008569_lethality_at_weaning0.99915510
96MP0001486_abnormal_startle_reflex0.99490174
97MP0002269_muscular_atrophy0.99338528
98MP0005083_abnormal_biliary_tract0.98517985
99MP0003566_abnormal_cell_adhesion0.97699272
100MP0003385_abnormal_body_wall0.97649621
101MP0009672_abnormal_birth_weight0.97298492
102MP0002557_abnormal_social/conspecific_i0.96438044
103MP0002066_abnormal_motor_capabilities/c0.95881133
104MP0008874_decreased_physiological_sensi0.94249791
105MP0005423_abnormal_somatic_nervous0.94128522
106MP0005360_urolithiasis0.94089178
107MP0000767_abnormal_smooth_muscle0.93186137
108MP0001348_abnormal_lacrimal_gland0.91822197
109MP0003075_altered_response_to0.91164433
110MP0000778_abnormal_nervous_system0.90819587
111MP0003786_premature_aging0.90615559
112MP0000762_abnormal_tongue_morphology0.90152329
113MP0003283_abnormal_digestive_organ0.89151699
114MP0000013_abnormal_adipose_tissue0.88787463
115MP0001501_abnormal_sleep_pattern0.87569179
116MP0003950_abnormal_plasma_membrane0.86850989
117MP0003137_abnormal_impulse_conducting0.86731736
118MP0003942_abnormal_urinary_system0.84689954
119MP0001919_abnormal_reproductive_system0.84323517
120MP0002882_abnormal_neuron_morphology0.83948872
121MP0003453_abnormal_keratinocyte_physiol0.82418327
122MP0010352_gastrointestinal_tract_polyps0.81869442
123MP0009384_cardiac_valve_regurgitation0.81460039
124MP0002067_abnormal_sensory_capabilities0.80866856
125MP0000003_abnormal_adipose_tissue0.79968413
126MP0002332_abnormal_exercise_endurance0.79910095
127MP0002139_abnormal_hepatobiliary_system0.79592640
128MP0003119_abnormal_digestive_system0.79291598
129MP0003936_abnormal_reproductive_system0.78711457
130MP0003634_abnormal_glial_cell0.78664959
131MP0005085_abnormal_gallbladder_physiolo0.78059810
132MP0004085_abnormal_heartbeat0.77808775
133MP0005595_abnormal_vascular_smooth0.77611650
134MP0002998_abnormal_bone_remodeling0.77103013
135MP0000678_abnormal_parathyroid_gland0.76404109
136MP0000534_abnormal_ureter_morphology0.75689488
137MP0005620_abnormal_muscle_contractility0.74740228
138MP0005386_behavior/neurological_phenoty0.74046335
139MP0004924_abnormal_behavior0.74046335
140MP0002108_abnormal_muscle_morphology0.73964533
141MP0008770_decreased_survivor_rate0.73926475
142MP0004233_abnormal_muscle_weight0.73620252
143MP0005666_abnormal_adipose_tissue0.73004830
144MP0005390_skeleton_phenotype0.71825707
145MP0003448_altered_tumor_morphology0.71214533
146MP0005409_darkened_coat_color0.70829515
147MP0002152_abnormal_brain_morphology0.69959686
148MP0002972_abnormal_cardiac_muscle0.69935803
149MP0005375_adipose_tissue_phenotype0.69463883
150MP0006276_abnormal_autonomic_nervous0.69315504
151MP0002106_abnormal_muscle_physiology0.69191719
152MP0008872_abnormal_physiological_respon0.68009528
153MP0002254_reproductive_system_inflammat0.67017574
154MP0001216_abnormal_epidermal_layer0.66527693
155MP0008775_abnormal_heart_ventricle0.66122987
156MP0003172_abnormal_lysosome_physiology0.65525049
157MP0001346_abnormal_lacrimal_gland0.64666824
158MP0005167_abnormal_blood-brain_barrier0.64114321
159MP0000647_abnormal_sebaceous_gland0.64012242
160MP0005187_abnormal_penis_morphology0.63573289
161MP0000604_amyloidosis0.63117583

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)6.11637883
2Myokymia (HP:0002411)5.97241416
3Ankle contracture (HP:0006466)5.58752674
4Slender build (HP:0001533)5.55673699
5Spinal rigidity (HP:0003306)4.84912807
6Hypoventilation (HP:0002791)3.81292174
7Focal motor seizures (HP:0011153)3.79290578
8* Achilles tendon contracture (HP:0001771)3.51288287
9Hyperacusis (HP:0010780)3.48644933
10Visual hallucinations (HP:0002367)3.47449554
11* Abnormality of the Achilles tendon (HP:0005109)3.38744389
12Generalized amyotrophy (HP:0003700)3.38231871
13Bladder diverticulum (HP:0000015)3.37123258
14Elbow flexion contracture (HP:0002987)3.13176163
15Focal seizures (HP:0007359)3.08742071
16Difficulty climbing stairs (HP:0003551)3.03661263
17Ventricular fibrillation (HP:0001663)3.03292785
18Abnormality of dentin (HP:0010299)2.92689150
19Testicular atrophy (HP:0000029)2.88181964
20Long palpebral fissure (HP:0000637)2.72377317
21Annular pancreas (HP:0001734)2.70135075
22Vertebral compression fractures (HP:0002953)2.70123408
23Myotonia (HP:0002486)2.68392906
24Right ventricular cardiomyopathy (HP:0011663)2.65037366
25Exercise-induced myalgia (HP:0003738)2.64971869
26Aortic dissection (HP:0002647)2.64544935
27Abnormality of the lower motor neuron (HP:0002366)2.63172887
28Renal duplication (HP:0000075)2.62139317
29Limb-girdle muscle weakness (HP:0003325)2.55533584
30Hypercortisolism (HP:0001578)2.54697267
31Hypotrichosis (HP:0001006)2.53427675
32Hand muscle atrophy (HP:0009130)2.53134939
33Depression (HP:0000716)2.53025246
34Lower limb amyotrophy (HP:0007210)2.51685959
35Soft skin (HP:0000977)2.47380134
36* Fragile nails (HP:0001808)2.47173854
37Abnormality of oral frenula (HP:0000190)2.46760968
38Blue sclerae (HP:0000592)2.45916910
39Vascular tortuosity (HP:0004948)2.44092099
40Increased connective tissue (HP:0009025)2.43636417
41Hyporeflexia of lower limbs (HP:0002600)2.43385316
42Pili torti (HP:0003777)2.42721050
43* Genu recurvatum (HP:0002816)2.39834886
44Cervical subluxation (HP:0003308)2.39355358
45Premature rupture of membranes (HP:0001788)2.38885188
46Delusions (HP:0000746)2.36505570
47Distal lower limb amyotrophy (HP:0008944)2.36326492
48Protruding ear (HP:0000411)2.34937597
49* Sudden death (HP:0001699)2.34380758
50Torticollis (HP:0000473)2.32861336
51Round ear (HP:0100830)2.32380766
52Arterial tortuosity (HP:0005116)2.31721728
53Protrusio acetabuli (HP:0003179)2.31250047
54Short nail (HP:0001799)2.29431160
55Distal lower limb muscle weakness (HP:0009053)2.26139706
56Anxiety (HP:0000739)2.25541665
57Deep venous thrombosis (HP:0002625)2.25286730
58Difficulty running (HP:0009046)2.24939762
59Long toe (HP:0010511)2.24877305
60Overriding aorta (HP:0002623)2.24635809
61Absence seizures (HP:0002121)2.24614254
62Myopathic facies (HP:0002058)2.24558867
63Increased variability in muscle fiber diameter (HP:0003557)2.24256881
64Rapidly progressive (HP:0003678)2.23782322
65Amblyopia (HP:0000646)2.23088890
66Limb-girdle muscle atrophy (HP:0003797)2.22722143
67Action tremor (HP:0002345)2.22343457
68Focal dystonia (HP:0004373)2.21903153
69Wormian bones (HP:0002645)2.21473852
70Distal arthrogryposis (HP:0005684)2.20882153
71Bowel diverticulosis (HP:0005222)2.20631343
72Truncus arteriosus (HP:0001660)2.20483744
73Hydroureter (HP:0000072)2.20200905
74Disproportionate tall stature (HP:0001519)2.17787168
75Mitral regurgitation (HP:0001653)2.17363407
76Craniofacial dystonia (HP:0012179)2.16526929
77Joint laxity (HP:0001388)2.16081646
78Resting tremor (HP:0002322)2.14963973
79Hyperextensible skin (HP:0000974)2.14305496
80Ankyloglossia (HP:0010296)2.13972007
81Elfin facies (HP:0004428)2.12104984
82Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11527140
83Ulnar bowing (HP:0003031)2.10300684
84Impaired social interactions (HP:0000735)2.10199919
85Abnormal social behavior (HP:0012433)2.10199919
86Cerebral aneurysm (HP:0004944)2.09777605
87Muscle fiber inclusion bodies (HP:0100299)2.09755163
88Hyperthyroidism (HP:0000836)2.09677607
89Conjunctival hamartoma (HP:0100780)2.07421378
90Type 1 muscle fiber predominance (HP:0003803)2.07416962
91Shoulder girdle muscle weakness (HP:0003547)2.07044682
92Exercise-induced muscle cramps (HP:0003710)2.05458643
93Onycholysis (HP:0001806)2.04655365
94Neonatal onset (HP:0003623)2.04606021
95Atrophic scars (HP:0001075)2.04129091
96Insomnia (HP:0100785)2.03987079
97Hallux valgus (HP:0001822)2.03974897
98Upper limb amyotrophy (HP:0009129)2.03918332
99Distal upper limb amyotrophy (HP:0007149)2.03918332
100Generalized tonic-clonic seizures (HP:0002069)2.03338131
101Milia (HP:0001056)2.03113029
102Congenital glaucoma (HP:0001087)2.00719858
103Muscle hypertrophy of the lower extremities (HP:0008968)2.00471975
104Supranuclear gaze palsy (HP:0000605)2.00441477
105Abnormality of skeletal muscle fiber size (HP:0012084)2.00058046
106EMG: myopathic abnormalities (HP:0003458)1.99838008
107Poor eye contact (HP:0000817)1.99287996
108Abnormal gallbladder physiology (HP:0012438)1.98619872
109Cholecystitis (HP:0001082)1.98619872
110Spinal cord lesions (HP:0100561)1.98571196
111Syringomyelia (HP:0003396)1.98571196
112Fragile skin (HP:0001030)1.97821667
113Ankle clonus (HP:0011448)1.97421779
114Hyperparathyroidism (HP:0000843)1.97302335
115Premature skin wrinkling (HP:0100678)1.97171460
116Status epilepticus (HP:0002133)1.96438951
117Deviation of the hallux (HP:0010051)1.95559102
118Plantar hyperkeratosis (HP:0007556)1.93634057
119Nemaline bodies (HP:0003798)1.91199914
120Hypercalcemia (HP:0003072)1.91048478
121Dialeptic seizures (HP:0011146)1.91008473
122Impaired vibration sensation in the lower limbs (HP:0002166)1.90661228
123Progressive muscle weakness (HP:0003323)1.90543738
124Natal tooth (HP:0000695)1.90214818
125Cerebral inclusion bodies (HP:0100314)1.90182894
126Muscle stiffness (HP:0003552)1.89317806
127Abnormal atrioventricular conduction (HP:0005150)1.88483079
128Mutism (HP:0002300)1.87362432
129Bundle branch block (HP:0011710)1.87344803
130Adducted thumb (HP:0001181)1.86957046
131Biconcave vertebral bodies (HP:0004586)1.86071013
132Aortic aneurysm (HP:0004942)1.85735523
133Abnormality of the calf musculature (HP:0001430)1.85368906
134Nail dystrophy (HP:0008404)1.84951626
135Mildly elevated creatine phosphokinase (HP:0008180)1.84753670
136Calf muscle hypertrophy (HP:0008981)1.84669609
137Abnormality of the umbilical cord (HP:0010881)1.80606310
138Ragged-red muscle fibers (HP:0003200)1.80124183
139Cardiovascular calcification (HP:0011915)1.78937350
140Atonic seizures (HP:0010819)1.78885799
141Urinary urgency (HP:0000012)1.78559446
142Trismus (HP:0000211)1.78322607
143Aplasia of the musculature (HP:0100854)1.76135518
144Dysdiadochokinesis (HP:0002075)1.76074009
145Hamartoma of the eye (HP:0010568)1.75474382
146Neonatal short-limb short stature (HP:0008921)1.74416474
147Gout (HP:0001997)1.74385010
148Short clavicles (HP:0000894)1.73280230
149* Woolly hair (HP:0002224)1.72472853
150Neurofibrillary tangles (HP:0002185)1.72217317
151* Osteopenia (HP:0000938)1.72052044
152Ventricular arrhythmia (HP:0004308)1.71244555
153Shallow orbits (HP:0000586)1.71236539
154Buphthalmos (HP:0000557)1.71187921
155Flat cornea (HP:0007720)1.70174817
156Pelvic girdle muscle weakness (HP:0003749)1.69939414
157Atrioventricular block (HP:0001678)1.69585633
158Muscle fiber splitting (HP:0003555)1.68657946
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67549216
160Multiple lipomas (HP:0001012)1.66000093
161Malnutrition (HP:0004395)1.65528031
162Sparse lateral eyebrow (HP:0005338)1.65318857
163Single umbilical artery (HP:0001195)1.64930620
164Abnormality of the fetal cardiovascular system (HP:0010948)1.64930620
165Abnormal umbilical cord blood vessels (HP:0011403)1.64930620
166Patellar dislocation (HP:0002999)1.62546794
167Vascular calcification (HP:0004934)1.62457967
168Stridor (HP:0010307)1.62006568
169Coxa vara (HP:0002812)1.60931013
170Joint stiffness (HP:0001387)1.60457186
171Ulnar deviation of the wrist (HP:0003049)1.60245367
172Renovascular hypertension (HP:0100817)1.58157621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.73281535
2IRAK33.69186401
3EPHA43.51800189
4TRIB33.35804151
5KSR22.79725382
6TLK12.71997137
7MINK12.37104691
8NTRK32.36535338
9LATS22.35343828
10SIK12.26622462
11DAPK22.26225609
12TAOK12.20910707
13RPS6KA22.20051762
14PKN22.15174734
15PRKD32.14597523
16GRK61.95465217
17PIM21.94293422
18MAP3K111.87479037
19GRK11.86802412
20NTRK11.76481068
21NEK11.74520143
22MARK11.71664328
23MYLK1.70389799
24FER1.67160457
25MAP3K21.64478135
26SCYL21.63888253
27DAPK31.61990636
28PAK61.61375075
29ADRBK21.58349877
30MAP2K41.53901489
31CAMKK11.52627369
32TAOK21.48438591
33PRPF4B1.45764838
34ARAF1.43615814
35MET1.42262487
36FLT31.41005484
37NME11.40100242
38GRK51.36328586
39PHKG11.35100492
40PHKG21.35100492
41STK381.33287054
42KSR11.32494549
43NME21.30111721
44EPHB21.30084190
45RPS6KL11.29083208
46RPS6KC11.29083208
47LIMK11.28707297
48DMPK1.27835059
49IKBKE1.26651229
50SMG11.24502799
51TYRO31.23636888
52MAP3K41.21883903
53ERBB41.18281140
54ILK1.17541113
55IRAK21.15781463
56TESK11.14936367
57CDK141.10959611
58CDK51.09623761
59AKT31.08268305
60TTN1.08168345
61ALK1.08144873
62RET1.06251099
63CDK71.05557798
64RIPK11.04338212
65CHUK1.04160080
66PAK11.03802217
67AKT21.03701887
68ERN11.03560750
69RPS6KA61.03554319
70MAP3K11.03210435
71LMTK21.02772588
72DAPK10.97771265
73PAK20.97749617
74CDK190.97432460
75CDK150.96604892
76TESK20.95902740
77BMX0.92359491
78UHMK10.91455517
79CDK180.90672122
80FES0.89474319
81CDK11A0.89307153
82EIF2AK10.84867199
83MAP3K120.84773931
84DDR20.83097499
85PTK2B0.82970914
86MTOR0.81579909
87STK110.81517175
88LRRK20.80377616
89MAP2K10.78600892
90MAPKAPK30.78376763
91NTRK20.74410078
92PDGFRA0.72489323
93SIK20.72354583
94MAPK40.72227428
95CDK80.72108262
96PRKCG0.70543317
97EEF2K0.70155671
98MAP3K130.69705765
99CDC42BPA0.69485077
100RIPK40.68477041
101ABL20.67802319
102RAF10.65915206
103PTK20.63479826
104EPHB10.62908269
105PDPK10.62262422
106ADRBK10.60475492
107PAK30.59105202
108MAP2K30.58312715
109PRKG20.56220687
110MAPKAPK20.54212237
111AURKA0.54094389
112PDGFRB0.50503600
113EPHA20.48476367
114CAMK2A0.47705418
115PRKCZ0.47356781
116MAP2K70.47004350
117PAK40.46841332
118TGFBR20.46574175
119BCKDK0.45492836
120MOS0.45080155
121PRKD20.44934757
122ICK0.44251508
123ROCK10.42624416
124PRKD10.42622320
125BRAF0.41931966
126CAMK2G0.41519620
127DYRK1B0.40904060
128MARK20.40763875
129MAP3K30.40569944
130CAMK10.40509219
131PRKCI0.40350892
132PDK10.40148062
133ZAP700.39847964
134MAP3K80.39375931
135PDK30.38249681
136PDK40.38249681
137MST1R0.38004966
138MAP2K20.37636896
139CSNK1E0.37591418
140STK160.37185259
141MAP3K60.36860165
142MAP3K50.36345990
143RPS6KB10.35999287
144ROCK20.35772352
145PTK60.35506213
146BRSK10.35255617

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.32747878
2Synaptic vesicle cycle_Homo sapiens_hsa047212.69088254
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.67947619
4ECM-receptor interaction_Homo sapiens_hsa045122.59364480
5Nitrogen metabolism_Homo sapiens_hsa009102.34262351
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34248600
7* Focal adhesion_Homo sapiens_hsa045102.29469156
8Olfactory transduction_Homo sapiens_hsa047402.18069994
9* Long-term potentiation_Homo sapiens_hsa047202.10674891
10Cardiac muscle contraction_Homo sapiens_hsa042601.98921724
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89800260
12Amphetamine addiction_Homo sapiens_hsa050311.84775217
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.84647138
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.83154537
15Dopaminergic synapse_Homo sapiens_hsa047281.77769535
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.68490946
17Gastric acid secretion_Homo sapiens_hsa049711.68389127
18Circadian entrainment_Homo sapiens_hsa047131.66426378
19GABAergic synapse_Homo sapiens_hsa047271.66128994
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.64819472
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61279320
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60844552
23Parkinsons disease_Homo sapiens_hsa050121.59226545
24Salivary secretion_Homo sapiens_hsa049701.57795632
25Ribosome_Homo sapiens_hsa030101.57680734
26* Gap junction_Homo sapiens_hsa045401.54918618
27Nicotine addiction_Homo sapiens_hsa050331.54072428
28Arginine biosynthesis_Homo sapiens_hsa002201.47785259
29Glutamatergic synapse_Homo sapiens_hsa047241.47696334
30* GnRH signaling pathway_Homo sapiens_hsa049121.46686475
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44115610
32* Glioma_Homo sapiens_hsa052141.43590438
33Vitamin B6 metabolism_Homo sapiens_hsa007501.43535520
34* Oxytocin signaling pathway_Homo sapiens_hsa049211.43061258
35* Chronic myeloid leukemia_Homo sapiens_hsa052201.41161247
36Sulfur relay system_Homo sapiens_hsa041221.40178294
37Small cell lung cancer_Homo sapiens_hsa052221.38896260
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37688113
39* Cholinergic synapse_Homo sapiens_hsa047251.37267079
40* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37036094
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34411236
42Oxidative phosphorylation_Homo sapiens_hsa001901.33880447
43* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.28423602
44* Melanogenesis_Homo sapiens_hsa049161.26279358
45Morphine addiction_Homo sapiens_hsa050321.26088000
46Insulin secretion_Homo sapiens_hsa049111.25403714
47Oocyte meiosis_Homo sapiens_hsa041141.24645986
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24510688
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21293052
50Renin secretion_Homo sapiens_hsa049241.20943303
51Alzheimers disease_Homo sapiens_hsa050101.20493577
52Cocaine addiction_Homo sapiens_hsa050301.20304673
53* Bladder cancer_Homo sapiens_hsa052191.19169941
54N-Glycan biosynthesis_Homo sapiens_hsa005101.16544595
55* VEGF signaling pathway_Homo sapiens_hsa043701.15979971
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14710105
57Salmonella infection_Homo sapiens_hsa051321.12061377
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10520629
59TNF signaling pathway_Homo sapiens_hsa046681.10055191
60Shigellosis_Homo sapiens_hsa051311.09465021
61Dilated cardiomyopathy_Homo sapiens_hsa054141.08357889
62* Long-term depression_Homo sapiens_hsa047301.06422239
63* Estrogen signaling pathway_Homo sapiens_hsa049151.05688042
64Bile secretion_Homo sapiens_hsa049761.03474334
65* Prolactin signaling pathway_Homo sapiens_hsa049171.02366774
66* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00690300
67Notch signaling pathway_Homo sapiens_hsa043301.00379003
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99254292
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98758544
70Calcium signaling pathway_Homo sapiens_hsa040200.97214790
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96572550
72Galactose metabolism_Homo sapiens_hsa000520.96021304
73Protein digestion and absorption_Homo sapiens_hsa049740.95662504
74* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94533256
75* Melanoma_Homo sapiens_hsa052180.94247365
76* Pathways in cancer_Homo sapiens_hsa052000.93827836
77Other glycan degradation_Homo sapiens_hsa005110.93567552
78* MicroRNAs in cancer_Homo sapiens_hsa052060.92464247
79Pentose phosphate pathway_Homo sapiens_hsa000300.90477055
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90421379
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88154894
82Huntingtons disease_Homo sapiens_hsa050160.86107098
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85879594
84Butanoate metabolism_Homo sapiens_hsa006500.85595535
85Pancreatic cancer_Homo sapiens_hsa052120.84926067
86* Axon guidance_Homo sapiens_hsa043600.83439312
87Lysosome_Homo sapiens_hsa041420.82816758
88Fructose and mannose metabolism_Homo sapiens_hsa000510.82405200
89Biosynthesis of amino acids_Homo sapiens_hsa012300.81589859
90* Endometrial cancer_Homo sapiens_hsa052130.80154791
91* Insulin signaling pathway_Homo sapiens_hsa049100.80112205
92Carbon metabolism_Homo sapiens_hsa012000.79964512
93Collecting duct acid secretion_Homo sapiens_hsa049660.79237103
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.79110767
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78401462
96* Tight junction_Homo sapiens_hsa045300.76045036
97mTOR signaling pathway_Homo sapiens_hsa041500.75784099
98Hippo signaling pathway_Homo sapiens_hsa043900.74562832
99* ErbB signaling pathway_Homo sapiens_hsa040120.74515766
100Glucagon signaling pathway_Homo sapiens_hsa049220.73834068
101cAMP signaling pathway_Homo sapiens_hsa040240.72873687
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70528790
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69766191
104* Non-small cell lung cancer_Homo sapiens_hsa052230.65861149
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64043062
106* Phospholipase D signaling pathway_Homo sapiens_hsa040720.63475635
107Malaria_Homo sapiens_hsa051440.63324612
108Thyroid hormone synthesis_Homo sapiens_hsa049180.60912812
109* Central carbon metabolism in cancer_Homo sapiens_hsa052300.60572177
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60128950
111Taste transduction_Homo sapiens_hsa047420.60103479
112* Rap1 signaling pathway_Homo sapiens_hsa040150.59816008
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59808333
114Dorso-ventral axis formation_Homo sapiens_hsa043200.57541509
115* Ras signaling pathway_Homo sapiens_hsa040140.56256796
116Prion diseases_Homo sapiens_hsa050200.55866225
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55819179
118* Apoptosis_Homo sapiens_hsa042100.55484208
119p53 signaling pathway_Homo sapiens_hsa041150.54014855
120Vibrio cholerae infection_Homo sapiens_hsa051100.53659074
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.52870006
122Pyrimidine metabolism_Homo sapiens_hsa002400.52194386
123* MAPK signaling pathway_Homo sapiens_hsa040100.52062493
124* Neurotrophin signaling pathway_Homo sapiens_hsa047220.51956259
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51491345
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51383570
127* Proteoglycans in cancer_Homo sapiens_hsa052050.51033558
128Hedgehog signaling pathway_Homo sapiens_hsa043400.50937713
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50200965
130* Endocytosis_Homo sapiens_hsa041440.49827219
131* Acute myeloid leukemia_Homo sapiens_hsa052210.49755944
132* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48987772
133AMPK signaling pathway_Homo sapiens_hsa041520.48962631
134* Thyroid cancer_Homo sapiens_hsa052160.48643666
135* Alcoholism_Homo sapiens_hsa050340.46887893
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46177246
137Adherens junction_Homo sapiens_hsa045200.45583927
138Wnt signaling pathway_Homo sapiens_hsa043100.45129908
139* Serotonergic synapse_Homo sapiens_hsa047260.44926682
140Rheumatoid arthritis_Homo sapiens_hsa053230.44848504
141HIF-1 signaling pathway_Homo sapiens_hsa040660.44508255
142* Sphingolipid signaling pathway_Homo sapiens_hsa040710.42628137
143* Renal cell carcinoma_Homo sapiens_hsa052110.42602251
144Basal cell carcinoma_Homo sapiens_hsa052170.42293698
145Pancreatic secretion_Homo sapiens_hsa049720.42245481
146Amoebiasis_Homo sapiens_hsa051460.42010650
147Colorectal cancer_Homo sapiens_hsa052100.39677230
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.37118938

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