HRASLS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)7.18885253
2muscle filament sliding (GO:0030049)6.68212994
3actin-myosin filament sliding (GO:0033275)6.68212994
4regulation of skeletal muscle contraction (GO:0014819)6.09487772
5actin-mediated cell contraction (GO:0070252)5.58272513
6skeletal muscle contraction (GO:0003009)5.48720325
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.81493600
8positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.56516952
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.55252968
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50685055
11synaptic vesicle exocytosis (GO:0016079)4.50364799
12negative regulation of protein localization to cell surface (GO:2000009)4.48138413
13vocalization behavior (GO:0071625)4.47914760
14negative regulation of heart rate (GO:0010459)4.46664126
15neuronal action potential propagation (GO:0019227)4.40151678
16glutamate secretion (GO:0014047)4.34427461
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32933140
18negative regulation of calcium ion transmembrane transport (GO:1903170)4.28246008
19negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.28246008
20protein localization to synapse (GO:0035418)4.22285700
21regulation of synaptic vesicle exocytosis (GO:2000300)4.21502568
22regulation of glutamate receptor signaling pathway (GO:1900449)4.20997168
23sperm motility (GO:0030317)4.13063651
24acrosome reaction (GO:0007340)4.11779552
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09071397
26negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.08246977
27neuron cell-cell adhesion (GO:0007158)4.07512523
28negative regulation of norepinephrine secretion (GO:0010700)4.06912859
29myotube cell development (GO:0014904)4.03973043
30striated muscle contraction (GO:0006941)4.03920754
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02866685
32blood coagulation, intrinsic pathway (GO:0007597)4.02223908
33calcium ion-dependent exocytosis (GO:0017156)4.00086298
34skeletal muscle tissue regeneration (GO:0043403)3.95010024
35cilium or flagellum-dependent cell motility (GO:0001539)3.93114258
36skeletal muscle fiber development (GO:0048741)3.92262960
37regulation of relaxation of muscle (GO:1901077)3.87591135
38positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.85836887
39creatine metabolic process (GO:0006600)3.84083979
40adenosine receptor signaling pathway (GO:0001973)3.82656814
41neurotransmitter-gated ion channel clustering (GO:0072578)3.82273750
42epithelial cilium movement (GO:0003351)3.81303364
43regulation of synaptic vesicle transport (GO:1902803)3.77930208
44behavioral response to nicotine (GO:0035095)3.77912169
45actin filament-based movement (GO:0030048)3.77814561
46myofibril assembly (GO:0030239)3.70332697
47synaptic vesicle maturation (GO:0016188)3.69630815
48relaxation of muscle (GO:0090075)3.69574056
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68520731
50membrane depolarization during action potential (GO:0086010)3.67678230
51presynaptic membrane assembly (GO:0097105)3.65245770
52axonemal dynein complex assembly (GO:0070286)3.62127775
53acrosome assembly (GO:0001675)3.59959706
54neuron-neuron synaptic transmission (GO:0007270)3.58016727
55polyamine biosynthetic process (GO:0006596)3.54941703
56neurotransmitter secretion (GO:0007269)3.53197110
57sarcomere organization (GO:0045214)3.52290884
58glycogen catabolic process (GO:0005980)3.51108624
59regulation of cilium movement (GO:0003352)3.50274632
60negative regulation of muscle contraction (GO:0045932)3.50063555
61presynaptic membrane organization (GO:0097090)3.49877941
62motile cilium assembly (GO:0044458)3.49403571
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.48964826
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.48390281
65response to histamine (GO:0034776)3.47863362
66cilium movement (GO:0003341)3.47219195
67negative regulation of appetite (GO:0032099)3.46976527
68negative regulation of response to food (GO:0032096)3.46976527
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.46118157
70NADH dehydrogenase complex assembly (GO:0010257)3.46118157
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46118157
72locomotory exploration behavior (GO:0035641)3.40216063
73negative regulation of homotypic cell-cell adhesion (GO:0034111)3.38368601
74thrombin receptor signaling pathway (GO:0070493)3.36695329
75fusion of sperm to egg plasma membrane (GO:0007342)3.35439077
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.35016647
77regulation of platelet aggregation (GO:0090330)3.34301947
78regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33552751
79regulation of cell communication by electrical coupling (GO:0010649)3.33491554
80regulation of female receptivity (GO:0045924)3.30788284
81regulation of integrin-mediated signaling pathway (GO:2001044)3.30787056
82glutamate receptor signaling pathway (GO:0007215)3.30545288
83negative regulation of catecholamine secretion (GO:0033604)3.30129223
84synaptic transmission, glutamatergic (GO:0035249)3.29993680
85postsynaptic membrane organization (GO:0001941)3.29845369
86cell wall macromolecule catabolic process (GO:0016998)3.26408114
87cell wall macromolecule metabolic process (GO:0044036)3.26408114
88regulation of protein kinase A signaling (GO:0010738)3.26377897
89detection of calcium ion (GO:0005513)3.25831375
90ubiquinone biosynthetic process (GO:0006744)3.25618059
91triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.25215482
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24635338
93muscle contraction (GO:0006936)3.24468928
94ATP hydrolysis coupled proton transport (GO:0015991)3.23422752
95energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23422752
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.22687484
97sarcoplasmic reticulum calcium ion transport (GO:0070296)3.22415378
98response to muscle activity (GO:0014850)3.20627952
99response to inactivity (GO:0014854)3.20343260
100regulation of synapse structural plasticity (GO:0051823)3.20008923
101glucan catabolic process (GO:0009251)3.19921113
102tricarboxylic acid cycle (GO:0006099)3.18846762
103relaxation of smooth muscle (GO:0044557)3.18528194
104negative regulation of inclusion body assembly (GO:0090084)3.16595197
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14610455
106positive regulation of synapse maturation (GO:0090129)3.11681333
107activation of protein kinase A activity (GO:0034199)3.11548138
108negative regulation of heart contraction (GO:0045822)3.10844662
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10594608
110regulation of acyl-CoA biosynthetic process (GO:0050812)3.09959174
111regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08681269
112plasma membrane fusion (GO:0045026)3.05622815
113long-term synaptic potentiation (GO:0060291)3.04151192
114regulation of platelet activation (GO:0010543)3.03298857
115mitochondrial calcium ion homeostasis (GO:0051560)3.02987722
116negative regulation of thymocyte apoptotic process (GO:0070244)3.02412236
117positive regulation of neurotransmitter transport (GO:0051590)3.02311120
118positive regulation of neurotransmitter secretion (GO:0001956)3.01415267
119protein complex biogenesis (GO:0070271)3.01133539
120regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.01007785
121regulation of neurotransmitter secretion (GO:0046928)3.00359794
122muscle system process (GO:0003012)2.99555819
123muscle fiber development (GO:0048747)2.99259534
124regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.99132462
125regulation of postsynaptic membrane potential (GO:0060078)2.97682900
126protein localization to cilium (GO:0061512)2.96304206
127striatum development (GO:0021756)2.95807247
128behavioral response to cocaine (GO:0048148)2.95717816
129membrane depolarization (GO:0051899)2.95161613
130cellular polysaccharide catabolic process (GO:0044247)2.94316982
131neurotransmitter transport (GO:0006836)2.94298964
132regulation of synaptic transmission, glutamatergic (GO:0051966)2.93341836
133regulation of norepinephrine secretion (GO:0014061)2.93049412
134exploration behavior (GO:0035640)2.92385794
135heart contraction (GO:0060047)2.92241190
136heart process (GO:0003015)2.92241190
137negative regulation of cation channel activity (GO:2001258)2.91872867
138regulation of neuronal synaptic plasticity (GO:0048168)2.91257658
139regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90890135
140regulation of long-term neuronal synaptic plasticity (GO:0048169)2.90673533
141beta-amyloid metabolic process (GO:0050435)2.89585871
142negative regulation of platelet activation (GO:0010544)2.89273350
143positive regulation of Rho protein signal transduction (GO:0035025)2.88903773
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88596606
145regulation of cofactor metabolic process (GO:0051193)2.87509219
146regulation of coenzyme metabolic process (GO:0051196)2.87509219
147regulation of calcium ion transmembrane transport (GO:1903169)2.86783100
148regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86783100
149cardiac muscle contraction (GO:0060048)2.85613512
150cerebellar Purkinje cell differentiation (GO:0021702)2.84714663
151regulation of voltage-gated calcium channel activity (GO:1901385)2.83069989
152cellular potassium ion homeostasis (GO:0030007)2.82830863
153neuromuscular synaptic transmission (GO:0007274)2.82221137
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.82205883
155cardiac muscle hypertrophy (GO:0003300)2.81657374
156cardiac myofibril assembly (GO:0055003)2.81580532
157negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80800123
158negative regulation of blood circulation (GO:1903523)2.80508148
159multicellular organism reproduction (GO:0032504)2.80392000
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80123401
161startle response (GO:0001964)2.79161359
162cerebellar granule cell differentiation (GO:0021707)2.78833927
163dopamine transport (GO:0015872)2.78300147
164negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.78210657
165positive regulation of membrane potential (GO:0045838)2.77449456
166regulation of synaptic plasticity (GO:0048167)2.77387810
167sperm-egg recognition (GO:0035036)2.77303098
168regulation of neurotransmitter transport (GO:0051588)2.77293373
169calcium ion import (GO:0070509)2.77219901
170gamma-aminobutyric acid transport (GO:0015812)2.76959647
171mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76775640
172mitochondrial respiratory chain complex assembly (GO:0033108)2.75190327
173regulation of lipoprotein metabolic process (GO:0050746)2.74966655
174purinergic nucleotide receptor signaling pathway (GO:0035590)2.74519865
175microtubule depolymerization (GO:0007019)2.74483266
176regulation of membrane repolarization (GO:0060306)2.73619392
177ubiquinone metabolic process (GO:0006743)2.72083662
178pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.69991774
179cellular biogenic amine biosynthetic process (GO:0042401)2.68495324
180positive regulation of endothelial cell differentiation (GO:0045603)2.67696608
181female mating behavior (GO:0060180)2.67657777
182mitochondrial calcium ion transport (GO:0006851)2.67314634
183striated muscle hypertrophy (GO:0014897)2.66961849
184glucan biosynthetic process (GO:0009250)2.64937144
185glycogen biosynthetic process (GO:0005978)2.64937144
186pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.63343340
187regulation of actin filament-based movement (GO:1903115)2.63106453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22133616
2GBX2_23144817_ChIP-Seq_PC3_Human3.44119294
3SRY_22984422_ChIP-ChIP_TESTIS_Rat2.79131052
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.78364064
5IGF1R_20145208_ChIP-Seq_DFB_Human2.69822329
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.67518992
7TAF15_26573619_Chip-Seq_HEK293_Human2.60069977
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57571467
9REST_21632747_ChIP-Seq_MESCs_Mouse2.50529708
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50507332
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40805777
12HTT_18923047_ChIP-ChIP_STHdh_Human2.33632246
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32658529
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17105218
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16147565
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.12762851
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12387784
18VDR_22108803_ChIP-Seq_LS180_Human2.11278567
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10094990
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10007426
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08645573
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02033959
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.98602552
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97594405
25DROSHA_22980978_ChIP-Seq_HELA_Human1.95482712
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.94801321
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91747669
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91630900
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91630900
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89874854
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86843094
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86741797
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.82608584
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82422413
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82035378
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79166060
37SMAD4_21799915_ChIP-Seq_A2780_Human1.78394548
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77379736
39EWS_26573619_Chip-Seq_HEK293_Human1.72325276
40ZNF274_21170338_ChIP-Seq_K562_Hela1.67453385
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.64083770
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.63909668
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.60835283
44* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57280074
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55369237
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54460731
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53369123
48FUS_26573619_Chip-Seq_HEK293_Human1.51795906
49P300_19829295_ChIP-Seq_ESCs_Human1.50386588
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49742008
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.43476296
52GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41134930
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39947192
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39779267
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39391219
56AR_21572438_ChIP-Seq_LNCaP_Human1.36445031
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.35627007
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33826184
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33461392
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33028836
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30049887
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29750821
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29308151
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.28287398
65AR_25329375_ChIP-Seq_VCAP_Human1.27716140
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27339375
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26449538
68RNF2_27304074_Chip-Seq_NSC_Mouse1.25934082
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24185814
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23923818
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23543912
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23497746
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.22182448
74SALL4_22934838_ChIP-ChIP_CD34+_Human1.22056958
75RBPJ_21746931_ChIP-Seq_IB4_Human1.20512440
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20426324
77* ER_23166858_ChIP-Seq_MCF-7_Human1.18322906
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18139826
79CBP_20019798_ChIP-Seq_JUKART_Human1.18139826
80* TCF4_23295773_ChIP-Seq_U87_Human1.17330758
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17131450
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17067719
83SOX2_19829295_ChIP-Seq_ESCs_Human1.17064910
84NANOG_19829295_ChIP-Seq_ESCs_Human1.17064910
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.16398481
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15538964
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14949276
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.14655832
89* STAT3_23295773_ChIP-Seq_U87_Human1.14424212
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14106607
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13972231
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.12831899
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12553073
94PHF8_20622853_ChIP-Seq_HELA_Human1.11176936
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10519494
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10476656
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10452575
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08774095
99KDM2B_26808549_Chip-Seq_REH_Human1.08105772
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.07075279
101SOX9_26525672_Chip-Seq_HEART_Mouse1.06926258
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.06844725
103NFYB_21822215_ChIP-Seq_K562_Human1.06528360
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.06249837
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06105418
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05728567
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05596138
108GATA2_19941826_ChIP-Seq_K562_Human1.04460684
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02605795
110GATA1_19941827_ChIP-Seq_MEL86_Mouse1.02048465
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01798677
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01622320
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01622320
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.01116600
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00760141
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00663552
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00434324
118BCAT_22108803_ChIP-Seq_LS180_Human0.99669372
119GATA6_21074721_ChIP-Seq_CACO-2_Human0.99388560
120TBL1_22424771_ChIP-Seq_293T_Human0.99047436
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98613061
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98373484
123NANOG_20526341_ChIP-Seq_ESCs_Human0.98290063
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98163454
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97132268
126P53_22387025_ChIP-Seq_ESCs_Mouse0.96926052
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.96801051
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.96795452
129CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95887629
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95371503
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95324922
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.94709272
133* AR_19668381_ChIP-Seq_PC3_Human0.94464884
134CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94458969
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.94334613
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.94244506
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93917237
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93500410
139AHR_22903824_ChIP-Seq_MCF-7_Human0.92979294
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.92871083
141RUNX2_22187159_ChIP-Seq_PCA_Human0.92016334
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.91862327
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91717023
144ETV1_20927104_ChIP-Seq_GIST48_Human0.91630264
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.91384068
146GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91308704
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.91204761
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.89975098
149NFYA_21822215_ChIP-Seq_K562_Human0.89686716
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87977044
151RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85394502
152PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84540056
153* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83924299
154* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83924299
155LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83812768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.57075396
2MP0004859_abnormal_synaptic_plasticity4.38789514
3MP0005464_abnormal_platelet_physiology4.18395479
4MP0005410_abnormal_fertilization3.56483046
5MP0003646_muscle_fatigue3.42763309
6MP0003635_abnormal_synaptic_transmissio3.30936487
7MP0000751_myopathy3.08828626
8MP0009046_muscle_twitch3.06918929
9MP0004270_analgesia2.99143691
10MP0004145_abnormal_muscle_electrophysio2.97519538
11MP0009745_abnormal_behavioral_response2.91957134
12MP0002837_dystrophic_cardiac_calcinosis2.90825379
13MP0001968_abnormal_touch/_nociception2.74424438
14MP0002064_seizures2.70657043
15MP0002063_abnormal_learning/memory/cond2.65056303
16MP0002572_abnormal_emotion/affect_behav2.40069188
17MP0002822_catalepsy2.36850480
18MP0002272_abnormal_nervous_system2.31984285
19MP0002736_abnormal_nociception_after2.27541583
20MP0001984_abnormal_olfaction2.23553476
21MP0000749_muscle_degeneration2.18799306
22MP0004036_abnormal_muscle_relaxation2.18690644
23MP0002734_abnormal_mechanical_nocicepti2.08118378
24MP0001486_abnormal_startle_reflex2.01361624
25MP0004233_abnormal_muscle_weight1.93972158
26MP0009780_abnormal_chondrocyte_physiolo1.93970676
27MP0001440_abnormal_grooming_behavior1.92431659
28MP0001501_abnormal_sleep_pattern1.89804127
29MP0004215_abnormal_myocardial_fiber1.85395121
30MP0002067_abnormal_sensory_capabilities1.82368522
31MP0005167_abnormal_blood-brain_barrier1.78323171
32MP0004510_myositis1.76984878
33MP0008004_abnormal_stomach_pH1.74225208
34MP0005646_abnormal_pituitary_gland1.68462923
35MP0005423_abnormal_somatic_nervous1.59449876
36MP0004084_abnormal_cardiac_muscle1.59048467
37MP0002735_abnormal_chemical_nociception1.56627311
38MP0001529_abnormal_vocalization1.56542561
39MP0006276_abnormal_autonomic_nervous1.55795441
40MP0004924_abnormal_behavior1.49842953
41MP0005386_behavior/neurological_phenoty1.49842953
42MP0005620_abnormal_muscle_contractility1.49311004
43MP0003879_abnormal_hair_cell1.49119952
44MP0000230_abnormal_systemic_arterial1.47811693
45MP0008569_lethality_at_weaning1.46777701
46MP0004484_altered_response_of1.45238651
47MP0010386_abnormal_urinary_bladder1.43918936
48MP0003698_abnormal_male_reproductive1.42359896
49MP0004130_abnormal_muscle_cell1.41978820
50MP0001970_abnormal_pain_threshold1.39903674
51MP0002106_abnormal_muscle_physiology1.39666441
52MP0000747_muscle_weakness1.39524660
53MP0004142_abnormal_muscle_tone1.35997623
54MP0005083_abnormal_biliary_tract1.34416961
55MP0002557_abnormal_social/conspecific_i1.33914237
56MP0002733_abnormal_thermal_nociception1.31938567
57MP0009697_abnormal_copulation1.31826898
58MP0002909_abnormal_adrenal_gland1.31045457
59MP0008877_abnormal_DNA_methylation1.30653300
60MP0005385_cardiovascular_system_phenoty1.26451974
61MP0001544_abnormal_cardiovascular_syste1.26451974
62MP0002269_muscular_atrophy1.23469708
63MP0003329_amyloid_beta_deposits1.22002892
64MP0004811_abnormal_neuron_physiology1.21207231
65MP0005551_abnormal_eye_electrophysiolog1.20842157
66MP0003633_abnormal_nervous_system1.19346706
67MP0000013_abnormal_adipose_tissue1.18676745
68MP0002184_abnormal_innervation1.18472761
69MP0003186_abnormal_redox_activity1.17785997
70MP0005645_abnormal_hypothalamus_physiol1.17765084
71MP0004085_abnormal_heartbeat1.17699996
72MP0005369_muscle_phenotype1.17568925
73MP0003787_abnormal_imprinting1.17000544
74MP0000759_abnormal_skeletal_muscle1.16186586
75MP0001502_abnormal_circadian_rhythm1.16071327
76MP0002066_abnormal_motor_capabilities/c1.16016707
77MP0004087_abnormal_muscle_fiber1.15561006
78MP0000372_irregular_coat_pigmentation1.15213000
79MP0003718_maternal_effect1.13387066
80MP0002332_abnormal_exercise_endurance1.13328140
81MP0003122_maternal_imprinting1.11757676
82MP0004147_increased_porphyrin_level1.11329862
83MP0002127_abnormal_cardiovascular_syste1.10357767
84MP0003638_abnormal_response/metabolism_1.09745668
85MP0008789_abnormal_olfactory_epithelium1.09475513
86MP0001661_extended_life_span1.06011586
87MP0001905_abnormal_dopamine_level1.05944503
88MP0002882_abnormal_neuron_morphology1.04025019
89MP0003011_delayed_dark_adaptation1.02115483
90MP0000778_abnormal_nervous_system1.01794323
91MP0003137_abnormal_impulse_conducting1.00560616
92MP0005451_abnormal_body_composition1.00537993
93MP0002972_abnormal_cardiac_muscle1.00277564
94MP0005330_cardiomyopathy0.99758328
95MP0000343_altered_response_to0.98054322
96MP0000955_abnormal_spinal_cord0.97684205
97MP0006036_abnormal_mitochondrial_physio0.97411054
98MP0004043_abnormal_pH_regulation0.95295376
99MP0006035_abnormal_mitochondrial_morpho0.94969582
100MP0005623_abnormal_meninges_morphology0.91885325
101MP0005499_abnormal_olfactory_system0.90629902
102MP0005394_taste/olfaction_phenotype0.90629902
103MP0001929_abnormal_gametogenesis0.90130798
104MP0004133_heterotaxia0.89026205
105MP0000465_gastrointestinal_hemorrhage0.88475892
106MP0003631_nervous_system_phenotype0.88120764
107MP0002163_abnormal_gland_morphology0.87387001
108MP0003828_pulmonary_edema0.85424893
109MP0005266_abnormal_metabolism0.85320557
110MP0005535_abnormal_body_temperature0.84671093
111MP0000733_abnormal_muscle_development0.84451327
112MP0002229_neurodegeneration0.83866380
113MP0002653_abnormal_ependyma_morphology0.83056782
114MP0009379_abnormal_foot_pigmentation0.81079708
115MP0005187_abnormal_penis_morphology0.81048151
116MP0001879_abnormal_lymphatic_vessel0.80412417
117MP0003123_paternal_imprinting0.80352256
118MP0008872_abnormal_physiological_respon0.80210792
119MP0002876_abnormal_thyroid_physiology0.77540374
120MP0001188_hyperpigmentation0.77213868
121MP0002152_abnormal_brain_morphology0.76161399
122MP0004858_abnormal_nervous_system0.75373720
123MP0000750_abnormal_muscle_regeneration0.75233586
124MP0008961_abnormal_basal_metabolism0.74523600
125MP0008874_decreased_physiological_sensi0.74303729
126MP0008775_abnormal_heart_ventricle0.72516658
127MP0005666_abnormal_adipose_tissue0.70435498
128MP0002161_abnormal_fertility/fecundity0.68827569
129MP0010630_abnormal_cardiac_muscle0.68809175
130MP0002069_abnormal_eating/drinking_beha0.67585288
131MP0005084_abnormal_gallbladder_morpholo0.65666318
132MP0006292_abnormal_olfactory_placode0.65575611
133MP0002078_abnormal_glucose_homeostasis0.64983121
134MP0002234_abnormal_pharynx_morphology0.64413193
135MP0000631_abnormal_neuroendocrine_gland0.64101083
136MP0006138_congestive_heart_failure0.64100137
137MP0002108_abnormal_muscle_morphology0.63599192
138MP0001963_abnormal_hearing_physiology0.62896990
139MP0002638_abnormal_pupillary_reflex0.61063050
140MP0002752_abnormal_somatic_nervous0.60652702

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.49272905
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.89092108
3Absent/shortened dynein arms (HP:0200106)5.89092108
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.33016058
5Increased mean platelet volume (HP:0011877)5.24828994
6Prolonged bleeding time (HP:0003010)5.09759494
7Exercise-induced myalgia (HP:0003738)5.03649979
8Menorrhagia (HP:0000132)4.88574615
9Abnormal platelet volume (HP:0011876)4.68762119
10Epileptic encephalopathy (HP:0200134)4.53475670
11Atonic seizures (HP:0010819)4.45086761
12Abnormal respiratory motile cilium physiology (HP:0012261)4.35166264
13Petechiae (HP:0000967)4.34517576
14Abnormal respiratory motile cilium morphology (HP:0005938)4.15525351
15Abnormal respiratory epithelium morphology (HP:0012253)4.15525351
16Muscle hypertrophy of the lower extremities (HP:0008968)4.14254387
17Exercise-induced muscle cramps (HP:0003710)4.07415755
18Focal seizures (HP:0007359)4.05068611
19Abnormal ciliary motility (HP:0012262)3.98928062
20Calf muscle hypertrophy (HP:0008981)3.96367852
21Febrile seizures (HP:0002373)3.94511634
22Purpura (HP:0000979)3.83273047
23Hyperventilation (HP:0002883)3.75169427
24Myokymia (HP:0002411)3.74084370
25Absence seizures (HP:0002121)3.69366074
26Visual hallucinations (HP:0002367)3.43011464
27Rhinitis (HP:0012384)3.36569513
28Dialeptic seizures (HP:0011146)3.26465915
29Broad-based gait (HP:0002136)3.12040929
30Abnormality of the calf musculature (HP:0001430)3.09196009
31Generalized tonic-clonic seizures (HP:0002069)3.08903605
32Abnormality of skeletal muscle fiber size (HP:0012084)2.91861452
33Hyperlipoproteinemia (HP:0010980)2.91670148
34Sudden death (HP:0001699)2.87884537
35Myoglobinuria (HP:0002913)2.87541990
36Muscle fiber inclusion bodies (HP:0100299)2.83331366
37Abnormality of the left ventricular outflow tract (HP:0011103)2.80223578
38Subaortic stenosis (HP:0001682)2.80223578
39Dysmetric saccades (HP:0000641)2.79834271
40Epistaxis (HP:0000421)2.76568273
41Neck muscle weakness (HP:0000467)2.70844721
42Progressive cerebellar ataxia (HP:0002073)2.69878955
43Absent phalangeal crease (HP:0006109)2.69680681
44Ulnar deviation of the wrist (HP:0003049)2.69345361
45Gaze-evoked nystagmus (HP:0000640)2.69343927
46Acute necrotizing encephalopathy (HP:0006965)2.68625980
473-Methylglutaconic aciduria (HP:0003535)2.67604410
48Infertility (HP:0000789)2.67272256
49Paralysis (HP:0003470)2.67037955
50Calcaneovalgus deformity (HP:0001848)2.66447260
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.65741095
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.64804074
53Hyporeflexia of lower limbs (HP:0002600)2.63689557
54Abnormal mitochondria in muscle tissue (HP:0008316)2.62960379
55Chronic bronchitis (HP:0004469)2.61326393
56Areflexia of lower limbs (HP:0002522)2.55522660
57Exercise intolerance (HP:0003546)2.54360414
58Abnormality of alanine metabolism (HP:0010916)2.50193036
59Hyperalaninemia (HP:0003348)2.50193036
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50193036
61Impaired platelet aggregation (HP:0003540)2.46906957
62Abnormal platelet function (HP:0011869)2.46906957
63Pheochromocytoma (HP:0002666)2.46107838
64Impaired vibration sensation in the lower limbs (HP:0002166)2.46048913
65Myotonia (HP:0002486)2.45667709
66Medial flaring of the eyebrow (HP:0010747)2.44652310
67Dysdiadochokinesis (HP:0002075)2.43767257
68Progressive macrocephaly (HP:0004481)2.39548381
69Poor eye contact (HP:0000817)2.37725089
70Frequent falls (HP:0002359)2.37597887
71Nemaline bodies (HP:0003798)2.32655913
72Abnormal pupillary function (HP:0007686)2.31566917
73EMG: myopathic abnormalities (HP:0003458)2.30097841
74Weak cry (HP:0001612)2.29624422
75Gait imbalance (HP:0002141)2.29330736
76Distal lower limb muscle weakness (HP:0009053)2.28235327
77Difficulty running (HP:0009046)2.27239102
78Hepatic necrosis (HP:0002605)2.25946563
79Progressive inability to walk (HP:0002505)2.25182599
80Muscle stiffness (HP:0003552)2.24859765
81Deformed tarsal bones (HP:0008119)2.24703722
82Central scotoma (HP:0000603)2.24113991
83Muscle fiber splitting (HP:0003555)2.23806972
84Bundle branch block (HP:0011710)2.23617156
85Distal lower limb amyotrophy (HP:0008944)2.22910340
86Inability to walk (HP:0002540)2.21519506
87Neuroendocrine neoplasm (HP:0100634)2.21247591
88Congenital primary aphakia (HP:0007707)2.16434564
89Dyschromatopsia (HP:0007641)2.16141555
90Urinary bladder sphincter dysfunction (HP:0002839)2.12028487
91Abnormality of the lower motor neuron (HP:0002366)2.11054780
92Left ventricular hypertrophy (HP:0001712)2.10399596
93Anxiety (HP:0000739)2.09025955
94Amblyopia (HP:0000646)2.08333821
95EMG: neuropathic changes (HP:0003445)2.06941758
96Abnormal social behavior (HP:0012433)2.05969856
97Impaired social interactions (HP:0000735)2.05969856
98Shoulder girdle muscle weakness (HP:0003547)2.05751769
99Hyperthyroidism (HP:0000836)2.03848748
100Abnormal finger flexion creases (HP:0006143)2.03682958
101Acute encephalopathy (HP:0006846)2.02703402
102Depression (HP:0000716)2.02313949
103Oligomenorrhea (HP:0000876)2.02023633
104Progressive muscle weakness (HP:0003323)2.01233730
105Type 1 muscle fiber predominance (HP:0003803)2.01166602
106Hepatocellular necrosis (HP:0001404)2.00569229
107Truncal ataxia (HP:0002078)1.99203132
108Fetal akinesia sequence (HP:0001989)1.98825943
109Abnormal eating behavior (HP:0100738)1.97936776
110Cerebral edema (HP:0002181)1.97839099
111Nephrogenic diabetes insipidus (HP:0009806)1.97767145
112Atrial fibrillation (HP:0005110)1.97287320
113Dilated cardiomyopathy (HP:0001644)1.97222981
114Poikilocytosis (HP:0004447)1.97080295
115Abnormal gallbladder physiology (HP:0012438)1.96784767
116Cholecystitis (HP:0001082)1.96784767
117Urinary urgency (HP:0000012)1.96683121
118Syncope (HP:0001279)1.95698273
119Increased intramyocellular lipid droplets (HP:0012240)1.95521089
120Optic disc pallor (HP:0000543)1.95399167
121Abnormality of lateral ventricle (HP:0030047)1.94044868
122Generalized muscle weakness (HP:0003324)1.93861062
123Ankle clonus (HP:0011448)1.91152209
124Dysmetria (HP:0001310)1.90752716
125Mitochondrial inheritance (HP:0001427)1.90303877
126Ventricular fibrillation (HP:0001663)1.89370792
127Primary atrial arrhythmia (HP:0001692)1.88598401
128Distal arthrogryposis (HP:0005684)1.87789638
129Increased variability in muscle fiber diameter (HP:0003557)1.85280361
130Impaired vibratory sensation (HP:0002495)1.83742927
131Hypoglycemic coma (HP:0001325)1.83268449
132Hemiparesis (HP:0001269)1.82573958
133Gingival bleeding (HP:0000225)1.81631282
134Round ear (HP:0100830)1.80615488
135Postural instability (HP:0002172)1.79774276
136Prolonged QT interval (HP:0001657)1.79498567
137Nephronophthisis (HP:0000090)1.78065649
138Lower limb amyotrophy (HP:0007210)1.77825655
139Asymmetric septal hypertrophy (HP:0001670)1.77734891
140Supraventricular tachycardia (HP:0004755)1.76964415
141Heart block (HP:0012722)1.76401888
142Hypoglycemic seizures (HP:0002173)1.76265444
143Rhabdomyolysis (HP:0003201)1.75996190
144Generalized aminoaciduria (HP:0002909)1.75555619
145Malignant hyperthermia (HP:0002047)1.75280012
146Abnormal EKG (HP:0003115)1.75176948
147Increased CSF lactate (HP:0002490)1.73907922
148Polyphagia (HP:0002591)1.73145924
149Hyperglycinemia (HP:0002154)1.72474657
150Hyperglycinuria (HP:0003108)1.71274002
151Rimmed vacuoles (HP:0003805)1.70334052
152Resting tremor (HP:0002322)1.70139616
153Myopathic facies (HP:0002058)1.70103095
154Renal Fanconi syndrome (HP:0001994)1.68636309
155Increased muscle lipid content (HP:0009058)1.68537459
156Conjunctival telangiectasia (HP:0000524)1.67125001
157Metaphyseal dysplasia (HP:0100255)1.67011428
158Lipoatrophy (HP:0100578)1.65045217
159Mildly elevated creatine phosphokinase (HP:0008180)1.64405458
160Abnormality of the neuromuscular junction (HP:0003398)1.63711833
161Fatigable weakness (HP:0003473)1.63711833
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.63646534
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61857772
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61857772
165Abnormal atrioventricular conduction (HP:0005150)1.59967873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.34725771
2PDK34.09139486
3PDK44.09139486
4EPHA43.82029831
5MST43.33567467
6NTRK33.11139170
7MAP3K42.70862328
8DAPK22.52508120
9PDK22.51004358
10MAP2K72.41837097
11EIF2AK12.38245885
12MAP3K122.30953658
13MAP4K22.25378609
14MAP3K92.23937851
15BMX2.19095727
16PHKG22.08243550
17PHKG12.08243550
18MAP2K42.04830399
19PIK3CG2.04644959
20OBSCN2.04341938
21CCNB12.02858139
22PRKD32.01764641
23CDK191.89893065
24ILK1.84906448
25DAPK11.71627767
26ARAF1.67718383
27MINK11.63289134
28RIPK41.60514209
29NME11.60145874
30PLK21.54967437
31PTK2B1.43612131
32PINK11.41227446
33PNCK1.40389489
34PAK61.35956543
35TTN1.33584367
36TRIM281.31940906
37AKT31.31317775
38TIE11.27049293
39KSR21.26353778
40MARK11.25632372
41NTRK21.25306804
42STK381.19062584
43BCKDK1.18424361
44PRPF4B1.13184525
45NEK11.12235773
46CAMKK11.09208129
47DYRK21.05037316
48CAMK2A1.04500511
49OXSR11.03312047
50LIMK11.03180320
51KSR11.02135632
52CAMKK21.02019382
53PKN11.00096358
54GRK50.99525220
55PRKCG0.98874166
56CDK50.95701489
57LMTK20.95566686
58MUSK0.93253018
59ADRBK20.91418939
60BRAF0.89191275
61CSNK1G30.87009531
62STK160.83677431
63SGK20.81646830
64STK30.81623909
65TNIK0.80861562
66CSNK1G10.78868703
67SGK2230.78812443
68SGK4940.78812443
69TEC0.78647774
70MAPKAPK30.78610168
71PDK10.76731977
72MYLK0.75174140
73MAPK130.74053126
74PAK10.73647306
75PIM20.73383974
76ICK0.72357224
77MAPK120.71262556
78STK390.70796025
79WNK40.70655573
80CAMK2B0.70378119
81GRK70.68590845
82ZAK0.67360807
83NTRK10.66590979
84RAF10.66296900
85ERBB30.65925787
86TESK10.65865719
87PDPK10.65779199
88PRKG10.65636599
89CAMK2D0.65621178
90FES0.65514137
91CSNK1G20.65325966
92NLK0.65222929
93CAMK10.63839015
94BMPR20.62064824
95BTK0.61929663
96MARK30.61752683
97TNK20.60400271
98MAP2K30.57908463
99SGK10.57886032
100PLK30.57593357
101DAPK30.57068895
102WNK10.56711563
103CAMK2G0.56697995
104PIK3CA0.56539522
105CDK180.54692365
106SGK30.54282360
107BRSK20.54274558
108STK110.53627571
109TYRO30.53014088
110MAP3K70.52611435
111MAP3K130.51968355
112VRK10.51235632
113PAK30.50553581
114CDK150.50217568
115SIK20.50123441
116EPHB20.49459001
117CDK140.48202169
118SRPK10.47243076
119PRKCE0.45613650
120SIK30.45164059
121BMPR1B0.44616642
122MAPK70.43949293
123BUB10.43399074
124MAP2K60.41680185
125ROCK10.41645943
126MAP3K10.40942306
127GRK10.40837681
128TAOK10.40670433
129AKT20.40520322
130CDK11A0.40139307
131RPS6KA30.39282035
132MAP2K10.39188201
133PRKACG0.38705051
134PBK0.38614529
135IRAK10.38323786
136TLK10.37784967
137PRKACA0.36891569
138DMPK0.36846801
139CAMK40.35489207
140STK240.34972620
141VRK20.34628464
142TSSK60.33330080
143ROCK20.32903813
144FER0.32298212
145PRKCH0.31796496
146CDK80.31586360
147ADRBK10.31345317
148WNK30.31140775
149PRKD10.29090465
150DYRK30.28961042
151ERBB20.28358159
152CSNK1D0.27869784
153INSRR0.26952601
154CSNK1A10.26575389
155BRSK10.26535780

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52431765
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22591877
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.89142670
4Olfactory transduction_Homo sapiens_hsa047402.70077421
5Platelet activation_Homo sapiens_hsa046112.45831339
6Cardiac muscle contraction_Homo sapiens_hsa042602.42872205
7Fatty acid elongation_Homo sapiens_hsa000622.42581658
8Circadian entrainment_Homo sapiens_hsa047132.39650076
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39348438
10Amphetamine addiction_Homo sapiens_hsa050312.38001524
11Long-term potentiation_Homo sapiens_hsa047202.37245468
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36846943
13Collecting duct acid secretion_Homo sapiens_hsa049662.36331405
14GABAergic synapse_Homo sapiens_hsa047272.29731028
15Nitrogen metabolism_Homo sapiens_hsa009102.26798777
16Morphine addiction_Homo sapiens_hsa050322.25252232
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.19203415
18Oxidative phosphorylation_Homo sapiens_hsa001902.11162236
19Glutamatergic synapse_Homo sapiens_hsa047241.98847589
20Arginine and proline metabolism_Homo sapiens_hsa003301.97713928
21Renin secretion_Homo sapiens_hsa049241.96250676
22Salivary secretion_Homo sapiens_hsa049701.86751851
23Insulin secretion_Homo sapiens_hsa049111.86273485
24Calcium signaling pathway_Homo sapiens_hsa040201.82732825
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82062825
26Oxytocin signaling pathway_Homo sapiens_hsa049211.77486682
27Dopaminergic synapse_Homo sapiens_hsa047281.76303521
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75736932
29Parkinsons disease_Homo sapiens_hsa050121.72081897
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71950224
31Gastric acid secretion_Homo sapiens_hsa049711.68398544
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67366644
33Taste transduction_Homo sapiens_hsa047421.66556187
34Alzheimers disease_Homo sapiens_hsa050101.64709911
35Sulfur relay system_Homo sapiens_hsa041221.50030514
36Sulfur metabolism_Homo sapiens_hsa009201.47835487
37Dilated cardiomyopathy_Homo sapiens_hsa054141.43039950
38Serotonergic synapse_Homo sapiens_hsa047261.39268408
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39108097
40Cholinergic synapse_Homo sapiens_hsa047251.38384882
41Huntingtons disease_Homo sapiens_hsa050161.33527845
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33257185
43Pyruvate metabolism_Homo sapiens_hsa006201.31758887
44Glucagon signaling pathway_Homo sapiens_hsa049221.31358604
45Pentose phosphate pathway_Homo sapiens_hsa000301.29971862
46Vibrio cholerae infection_Homo sapiens_hsa051101.28775057
47Long-term depression_Homo sapiens_hsa047301.28167779
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25516171
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24826420
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22369725
51Cocaine addiction_Homo sapiens_hsa050301.21166747
52Mismatch repair_Homo sapiens_hsa034301.20540751
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20365666
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17835894
55Phototransduction_Homo sapiens_hsa047441.15940135
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14163450
57cAMP signaling pathway_Homo sapiens_hsa040241.13980853
58Glutathione metabolism_Homo sapiens_hsa004801.05172763
59Vascular smooth muscle contraction_Homo sapiens_hsa042701.04834018
60GnRH signaling pathway_Homo sapiens_hsa049121.04219297
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99254746
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98964487
63Gap junction_Homo sapiens_hsa045400.97598059
64Purine metabolism_Homo sapiens_hsa002300.97333052
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96595003
66Circadian rhythm_Homo sapiens_hsa047100.95916908
67Starch and sucrose metabolism_Homo sapiens_hsa005000.90748307
68Propanoate metabolism_Homo sapiens_hsa006400.88593389
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87352929
70Galactose metabolism_Homo sapiens_hsa000520.87268889
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86216688
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85965998
73RNA polymerase_Homo sapiens_hsa030200.84231189
74ECM-receptor interaction_Homo sapiens_hsa045120.83273414
75Estrogen signaling pathway_Homo sapiens_hsa049150.82515373
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81824504
77Oocyte meiosis_Homo sapiens_hsa041140.81815422
78beta-Alanine metabolism_Homo sapiens_hsa004100.81774444
79Type II diabetes mellitus_Homo sapiens_hsa049300.81546636
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78596168
81Carbon metabolism_Homo sapiens_hsa012000.76440395
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74092635
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72484047
84One carbon pool by folate_Homo sapiens_hsa006700.72340888
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72171234
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69731097
87Arachidonic acid metabolism_Homo sapiens_hsa005900.69473896
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69232997
89Fatty acid metabolism_Homo sapiens_hsa012120.68221105
90Dorso-ventral axis formation_Homo sapiens_hsa043200.67790084
91Tight junction_Homo sapiens_hsa045300.66744116
92Melanogenesis_Homo sapiens_hsa049160.65507970
93Pancreatic secretion_Homo sapiens_hsa049720.64944121
94Pyrimidine metabolism_Homo sapiens_hsa002400.64703769
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64176815
96Fatty acid biosynthesis_Homo sapiens_hsa000610.63795756
97Glycerolipid metabolism_Homo sapiens_hsa005610.61944811
98MAPK signaling pathway_Homo sapiens_hsa040100.60814364
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.60780873
100Insulin signaling pathway_Homo sapiens_hsa049100.59730678
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59430898
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58826978
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58411062
104Fatty acid degradation_Homo sapiens_hsa000710.57865005
105Fructose and mannose metabolism_Homo sapiens_hsa000510.57174198
106Metabolic pathways_Homo sapiens_hsa011000.53113867
107ErbB signaling pathway_Homo sapiens_hsa040120.53007705
108Glioma_Homo sapiens_hsa052140.50419222
109Linoleic acid metabolism_Homo sapiens_hsa005910.49734399
110Axon guidance_Homo sapiens_hsa043600.49679349
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45415241
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45146944
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44870243
114Thyroid hormone synthesis_Homo sapiens_hsa049180.44676994
115Rheumatoid arthritis_Homo sapiens_hsa053230.43416971
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43128739
117Notch signaling pathway_Homo sapiens_hsa043300.40109548
118Vitamin B6 metabolism_Homo sapiens_hsa007500.39959497
119Biosynthesis of amino acids_Homo sapiens_hsa012300.39766286
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39265101
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38388536
122Inositol phosphate metabolism_Homo sapiens_hsa005620.37840638
123Butanoate metabolism_Homo sapiens_hsa006500.36875995
124VEGF signaling pathway_Homo sapiens_hsa043700.36593033
125Peroxisome_Homo sapiens_hsa041460.33679787
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.32559589
127PPAR signaling pathway_Homo sapiens_hsa033200.32228288
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31292997
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.30790476
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30683817
131Ras signaling pathway_Homo sapiens_hsa040140.30050419
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29313294
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26840207
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.24279086
135AMPK signaling pathway_Homo sapiens_hsa041520.23949292
136Alcoholism_Homo sapiens_hsa050340.23862964
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23632797
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.23532022
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.22575026
140Phagosome_Homo sapiens_hsa041450.22388597
141Type I diabetes mellitus_Homo sapiens_hsa049400.22106089
142Bile secretion_Homo sapiens_hsa049760.20493022
143Ovarian steroidogenesis_Homo sapiens_hsa049130.19451178

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