HRASLS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.30626882
2motile cilium assembly (GO:0044458)9.25610724
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.18274880
4epithelial cilium movement (GO:0003351)7.97461248
5primary alcohol catabolic process (GO:0034310)6.72804721
6vitamin transmembrane transport (GO:0035461)6.08939284
7axoneme assembly (GO:0035082)5.77295543
8ethanol metabolic process (GO:0006067)5.42197561
9diterpenoid biosynthetic process (GO:0016102)5.30728536
10left/right pattern formation (GO:0060972)4.77837812
11pyrimidine-containing compound transmembrane transport (GO:0072531)4.67178661
12ethanol oxidation (GO:0006069)4.50741844
13tolerance induction (GO:0002507)4.12915270
14antibacterial humoral response (GO:0019731)4.09951639
15O-glycan processing (GO:0016266)4.08074842
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03781860
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01482813
18antigen processing and presentation of endogenous antigen (GO:0019883)3.93503656
19regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.93468993
20antimicrobial humoral response (GO:0019730)3.93136443
21regulation of cilium movement (GO:0003352)3.88269594
22angiotensin maturation (GO:0002003)3.84975038
23sperm capacitation (GO:0048240)3.84388572
24one-carbon compound transport (GO:0019755)3.83324618
25negative regulation of humoral immune response (GO:0002921)3.76818657
26terpenoid biosynthetic process (GO:0016114)3.76338335
27retinoic acid metabolic process (GO:0042573)3.72002565
28epoxygenase P450 pathway (GO:0019373)3.70751563
29NADH metabolic process (GO:0006734)3.69167159
30exogenous drug catabolic process (GO:0042738)3.57309108
31regulation of germinal center formation (GO:0002634)3.56257016
32multicellular organismal water homeostasis (GO:0050891)3.55894581
33innate immune response in mucosa (GO:0002227)3.55047968
34primary alcohol metabolic process (GO:0034308)3.42596920
35oligosaccharide biosynthetic process (GO:0009312)3.40210017
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.39741203
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38539186
38left/right axis specification (GO:0070986)3.37839643
39glutathione derivative biosynthetic process (GO:1901687)3.37108827
40glutathione derivative metabolic process (GO:1901685)3.37108827
41negative regulation of immunoglobulin mediated immune response (GO:0002890)3.33311469
42negative regulation of B cell mediated immunity (GO:0002713)3.33311469
43regulation of interleukin-13 production (GO:0032656)3.32548797
44ventricular system development (GO:0021591)3.29513874
45phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.28067288
46microtubule bundle formation (GO:0001578)3.25382078
47negative regulation of T cell differentiation in thymus (GO:0033085)3.24510728
48regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.22706753
49glutathione metabolic process (GO:0006749)3.21560695
50calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.20612997
51flavonoid metabolic process (GO:0009812)3.20091815
52response to xenobiotic stimulus (GO:0009410)3.19339325
53gonadal mesoderm development (GO:0007506)3.16996146
54cellular glucuronidation (GO:0052695)3.16165293
55glucuronate metabolic process (GO:0019585)3.14578906
56uronic acid metabolic process (GO:0006063)3.14578906
57response to type I interferon (GO:0034340)3.11522235
58type I interferon signaling pathway (GO:0060337)3.11396632
59cellular response to type I interferon (GO:0071357)3.11396632
60mucosal immune response (GO:0002385)3.08077177
61drug catabolic process (GO:0042737)3.07967579
62progesterone metabolic process (GO:0042448)3.06984582
63lipoprotein transport (GO:0042953)3.05108764
64centriole assembly (GO:0098534)3.04629084
65drug metabolic process (GO:0017144)3.04258835
66hydrogen peroxide biosynthetic process (GO:0050665)3.02533020
67retinol metabolic process (GO:0042572)3.01276089
68water homeostasis (GO:0030104)2.99580501
69positive regulation of tolerance induction (GO:0002645)2.93897197
70peptide catabolic process (GO:0043171)2.92135818
71glutathione biosynthetic process (GO:0006750)2.89802149
72organ or tissue specific immune response (GO:0002251)2.88989886
73phenol-containing compound catabolic process (GO:0019336)2.85642054
74immunoglobulin mediated immune response (GO:0016064)2.83445953
75glomerular epithelial cell development (GO:0072310)2.82412390
76regulation of interleukin-5 production (GO:0032674)2.79576413
77regulation of tolerance induction (GO:0002643)2.78673522
78intraciliary transport (GO:0042073)2.78294062
79excretion (GO:0007588)2.75296185
80Golgi transport vesicle coating (GO:0048200)2.74708730
81COPI coating of Golgi vesicle (GO:0048205)2.74708730
82nonribosomal peptide biosynthetic process (GO:0019184)2.73443787
83carnitine metabolic process (GO:0009437)2.67511452
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.67325025
85maintenance of gastrointestinal epithelium (GO:0030277)2.66955191
86negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.66825970
87lung epithelium development (GO:0060428)2.66377506
88hydrogen peroxide metabolic process (GO:0042743)2.64333347
89sodium ion homeostasis (GO:0055078)2.63078994
90desmosome organization (GO:0002934)2.62705154
91cilium organization (GO:0044782)2.62419698
92hydrogen peroxide catabolic process (GO:0042744)2.62107749
93leukotriene metabolic process (GO:0006691)2.61583159
94reactive oxygen species biosynthetic process (GO:1903409)2.60397020
95L-ascorbic acid metabolic process (GO:0019852)2.58844471
96intestinal epithelial cell development (GO:0060576)2.53593184
97interferon-gamma-mediated signaling pathway (GO:0060333)2.52227189
98protein O-linked glycosylation (GO:0006493)2.51810245
99axonemal dynein complex assembly (GO:0070286)14.1522854
100cilium or flagellum-dependent cell motility (GO:0001539)11.0885748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24663434
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.97482326
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.83538186
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.69978625
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.38935861
6* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22465254
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.87517489
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.60055768
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.52948120
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41704144
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.34831335
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.30880852
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21277309
14SOX2_20726797_ChIP-Seq_SW620_Human2.12094748
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11502086
16ZNF263_19887448_ChIP-Seq_K562_Human2.09316412
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96793321
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89174871
19* GATA4_25053715_ChIP-Seq_YYC3_Human1.87598781
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86367979
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.83294877
22* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76537751
23STAT1_20625510_ChIP-Seq_HELA_Human1.71336883
24* GATA6_25053715_ChIP-Seq_YYC3_Human1.70160825
25* RACK7_27058665_Chip-Seq_MCF-7_Human1.67352428
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.67263137
27* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.66750059
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65199925
29* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.62146341
30* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61500280
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.56998964
32LXR_22292898_ChIP-Seq_THP-1_Human1.54696157
33* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49967868
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48475656
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47414225
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43960030
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.42634172
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41937071
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40953080
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40692736
41* MAF_26560356_Chip-Seq_TH1_Human1.40642287
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38615361
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34983658
44GATA1_19941826_ChIP-Seq_K562_Human1.33464564
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33354476
46* GATA3_24758297_ChIP-Seq_MCF-7_Human1.32450841
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.27617240
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.27193287
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.26184482
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.24910918
51* KLF5_25053715_ChIP-Seq_YYC3_Human1.24655549
52TP63_22573176_ChIP-Seq_HFKS_Human1.24170943
53FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23919898
54VDR_24763502_ChIP-Seq_THP-1_Human1.22357221
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22352891
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22003743
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18269720
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17948894
59* BCOR_27268052_Chip-Seq_Bcells_Human1.16515393
60* SMC4_20622854_ChIP-Seq_HELA_Human1.15500950
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.14488119
62DROSHA_22980978_ChIP-Seq_HELA_Human1.13656218
63BCL6_27268052_Chip-Seq_Bcells_Human1.13580619
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13564898
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13326298
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13029269
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11396845
68GATA2_19941826_ChIP-Seq_K562_Human1.11335475
69P300_27268052_Chip-Seq_Bcells_Human1.10674763
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10603334
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09713677
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07421523
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06741630
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.06028401
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.05458915
76MYB_26560356_Chip-Seq_TH2_Human1.04340432
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.03972581
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.03710791
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01222607
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01000056
81NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00579098
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99745079
83VDR_21846776_ChIP-Seq_THP-1_Human0.98615874
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98297986
85* MYB_26560356_Chip-Seq_TH1_Human0.97875490
86CEBPB_22108803_ChIP-Seq_LS180_Human0.97200095
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95468936
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94722497
89* P68_20966046_ChIP-Seq_HELA_Human0.94598545
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94070793
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93721792
92* TP63_23658742_ChIP-Seq_EP156T_Human0.91443608
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91344598
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91159810
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91133109
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90350933
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89723888
98ELF5_23300383_ChIP-Seq_T47D_Human0.89327139
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89280268
100CLOCK_20551151_ChIP-Seq_293T_Human0.89134135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok3.99037237
2MP0010234_abnormal_vibrissa_follicle3.62452341
3MP0005360_urolithiasis3.42424452
4MP0010155_abnormal_intestine_physiology3.19196940
5MP0003183_abnormal_peptide_metabolism3.09351088
6MP0005085_abnormal_gallbladder_physiolo3.03746597
7MP0004264_abnormal_extraembryonic_tissu3.02018630
8MP0002132_abnormal_respiratory_system2.86594706
9MP0004019_abnormal_vitamin_homeostasis2.63356146
10MP0000685_abnormal_immune_system2.62962756
11MP0002139_abnormal_hepatobiliary_system2.62273631
12MP0001666_abnormal_nutrient_absorption2.60844202
13MP0003806_abnormal_nucleotide_metabolis2.41262039
14MP0005387_immune_system_phenotype2.39527137
15MP0001790_abnormal_immune_system2.39527137
16MP0001835_abnormal_antigen_presentation2.38787064
17MP0004043_abnormal_pH_regulation2.19748517
18MP0005365_abnormal_bile_salt2.15092286
19MP0003303_peritoneal_inflammation2.12284668
20MP0002653_abnormal_ependyma_morphology1.97753198
21MP0009379_abnormal_foot_pigmentation1.96865512
22MP0005671_abnormal_response_to1.90027672
23MP0003866_abnormal_defecation1.85196103
24MP0001800_abnormal_humoral_immune1.73530759
25MP0001765_abnormal_ion_homeostasis1.71496251
26MP0002166_altered_tumor_susceptibility1.68673695
27MP0009643_abnormal_urine_homeostasis1.68112982
28MP0009785_altered_susceptibility_to1.62767576
29MP0009780_abnormal_chondrocyte_physiolo1.62714449
30MP0000490_abnormal_crypts_of1.60536682
31MP0005025_abnormal_response_to1.60406062
32MP0002277_abnormal_respiratory_mucosa1.56572605
33MP0005310_abnormal_salivary_gland1.55533210
34MP0005464_abnormal_platelet_physiology1.48377533
35MP0005645_abnormal_hypothalamus_physiol1.48216274
36MP0001845_abnormal_inflammatory_respons1.43848112
37MP0002136_abnormal_kidney_physiology1.43412909
38MP0002796_impaired_skin_barrier1.42324325
39MP0005166_decreased_susceptibility_to1.41362222
40MP0002148_abnormal_hypersensitivity_rea1.39599555
41MP0005083_abnormal_biliary_tract1.36539771
42MP0003763_abnormal_thymus_physiology1.34952119
43MP0000465_gastrointestinal_hemorrhage1.34695209
44MP0002452_abnormal_antigen_presenting1.34243476
45MP0000858_altered_metastatic_potential1.33280147
46MP0005165_increased_susceptibility_to1.31385229
47MP0005623_abnormal_meninges_morphology1.31161005
48MP0009333_abnormal_splenocyte_physiolog1.30120762
49MP0000678_abnormal_parathyroid_gland1.29996834
50MP0001346_abnormal_lacrimal_gland1.29057842
51MP0005000_abnormal_immune_tolerance1.28124447
52MP0002876_abnormal_thyroid_physiology1.28078677
53MP0006082_CNS_inflammation1.26133650
54MP0009840_abnormal_foam_cell1.26089790
55MP0002723_abnormal_immune_serum1.25038534
56MP0003252_abnormal_bile_duct1.23425625
57MP0004947_skin_inflammation1.21977029
58MP0003453_abnormal_keratinocyte_physiol1.20741900
59MP0005636_abnormal_mineral_homeostasis1.20532748
60MP0001663_abnormal_digestive_system1.20332260
61MP0005501_abnormal_skin_physiology1.18476043
62MP0001664_abnormal_digestion1.17338979
63MP0010678_abnormal_skin_adnexa1.15386851
64MP0001819_abnormal_immune_cell1.11662490
65MP0002420_abnormal_adaptive_immunity1.11444400
66MP0005395_other_phenotype1.08417541
67MP0000477_abnormal_intestine_morphology1.06409333
68MP0002006_tumorigenesis1.04726717
69MP0002168_other_aberrant_phenotype1.04568760
70MP0003191_abnormal_cellular_cholesterol1.04439527
71MP0001873_stomach_inflammation1.03713077
72MP0008789_abnormal_olfactory_epithelium1.02117024
73MP0003436_decreased_susceptibility_to1.02039244
74MP0003868_abnormal_feces_composition0.97697922
75MP0003718_maternal_effect0.97323450
76MP0001764_abnormal_homeostasis0.96963810
77MP0008872_abnormal_physiological_respon0.94468028
78MP0008469_abnormal_protein_level0.91533975
79MP0009763_increased_sensitivity_to0.90666220
80MP0005332_abnormal_amino_acid0.88762933
81MP0000716_abnormal_immune_system0.87862047
82MP0003656_abnormal_erythrocyte_physiolo0.86939970
83MP0000566_synostosis0.86769512
84MP0000609_abnormal_liver_physiology0.85266977
85MP0010352_gastrointestinal_tract_polyps0.81953478
86MP0001984_abnormal_olfaction0.81885160
87MP0005584_abnormal_enzyme/coenzyme_acti0.81303494
88MP0002419_abnormal_innate_immunity0.81065632
89MP0000383_abnormal_hair_follicle0.80341696
90MP0003045_fibrosis0.79980833
91MP0002398_abnormal_bone_marrow0.79935669
92MP0003075_altered_response_to0.79845141
93MP0004782_abnormal_surfactant_physiolog0.79670495
94MP0001216_abnormal_epidermal_layer0.78694047
95MP0002098_abnormal_vibrissa_morphology0.77808055
96MP0005381_digestive/alimentary_phenotyp0.77317618
97MP0002138_abnormal_hepatobiliary_system0.77291774
98MP0005023_abnormal_wound_healing0.76770449
99MP0003724_increased_susceptibility_to0.75262699
100MP0009765_abnormal_xenobiotic_induced0.75057300

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.57703318
2Abnormal respiratory epithelium morphology (HP:0012253)9.57703318
3Abnormal respiratory motile cilium physiology (HP:0012261)9.44858852
4Abnormal ciliary motility (HP:0012262)9.10421433
5Rhinitis (HP:0012384)9.07046665
6Dynein arm defect of respiratory motile cilia (HP:0012255)9.06316085
7Absent/shortened dynein arms (HP:0200106)9.06316085
8Chronic bronchitis (HP:0004469)7.37377498
9Bronchiectasis (HP:0002110)7.23545751
10Nasal polyposis (HP:0100582)6.75740458
11Abnormality of the nasal mucosa (HP:0000433)5.62676510
12Recurrent sinusitis (HP:0011108)5.48048138
13Bronchitis (HP:0012387)4.94993249
14Chronic sinusitis (HP:0011109)4.70205058
15Hyperactive renin-angiotensin system (HP:0000841)4.54503112
16Recurrent otitis media (HP:0000403)4.20212864
17Chronic otitis media (HP:0000389)3.72512664
18Infertility (HP:0000789)3.63713293
19Male infertility (HP:0003251)3.36725704
20Recurrent bronchitis (HP:0002837)3.28354078
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77690852
22Decreased circulating renin level (HP:0003351)2.72287945
23Malnutrition (HP:0004395)2.71562755
24Gastrointestinal stroma tumor (HP:0100723)2.57250942
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46973570
26Atelectasis (HP:0100750)2.34167645
27Chronic diarrhea (HP:0002028)2.23162286
28Abnormality of renin-angiotensin system (HP:0000847)2.19315724
29Occipital encephalocele (HP:0002085)2.13188310
30Flat acetabular roof (HP:0003180)2.11859839
31Renal salt wasting (HP:0000127)2.03626650
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7467645
33Hyperaldosteronism (HP:0000859)1.96195525
34Recurrent pneumonia (HP:0006532)1.91887706
35True hermaphroditism (HP:0010459)1.88518439
36Hyperkalemia (HP:0002153)1.83492700
37Abnormality of chloride homeostasis (HP:0011422)1.82650705
38Fat malabsorption (HP:0002630)1.81635310
39Pancreatic fibrosis (HP:0100732)1.79702063
40Alkalosis (HP:0001948)1.75114352
41Hyponatremia (HP:0002902)1.70368427
42IgM deficiency (HP:0002850)1.68668981
43Eczematoid dermatitis (HP:0000976)1.64316984
44Tubulointerstitial nephritis (HP:0001970)1.63855487
45Cystic liver disease (HP:0006706)1.62331981
46IgA deficiency (HP:0002720)1.59719072
47Abnormality of proline metabolism (HP:0010907)1.56418484
48Hydroxyprolinuria (HP:0003080)1.56418484
49Abnormality of the distal phalanges of the toes (HP:0010182)1.51864817
50Hypotension (HP:0002615)1.48091352
51Abnormality of vitamin metabolism (HP:0100508)1.47655356
52Dehydration (HP:0001944)1.46112579
53Onycholysis (HP:0001806)1.46082759
54Agammaglobulinemia (HP:0004432)1.45509480
55Purpura (HP:0000979)1.43944833
56Chronic hepatic failure (HP:0100626)1.43386825
57Nephropathy (HP:0000112)1.41476553
58Dry hair (HP:0011359)1.41195494
59Petechiae (HP:0000967)1.40486056
60Hypobetalipoproteinemia (HP:0003563)1.40372624
61Steatorrhea (HP:0002570)1.38098704
62Abnormality of the vitamin B12 metabolism (HP:0004341)1.37467182
63Vasculitis (HP:0002633)1.37463748
64Elevated erythrocyte sedimentation rate (HP:0003565)1.36954077
65Pancreatic cysts (HP:0001737)1.36660491
66Recurrent lower respiratory tract infections (HP:0002783)1.35061347
67Asplenia (HP:0001746)1.35014592
68Abnormal glucose tolerance (HP:0001952)1.34176364
69Glucose intolerance (HP:0000833)1.33532703
70Bell-shaped thorax (HP:0001591)1.32132955
71Adrenal overactivity (HP:0002717)1.31808039
72Gout (HP:0001997)1.29176507
73Hypokalemic alkalosis (HP:0001949)1.29106456
74Furrowed tongue (HP:0000221)1.28780067
75Hemorrhage of the eye (HP:0011885)1.28328092
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.28301961
77Recurrent bacterial skin infections (HP:0005406)1.27069062
78Spinal cord compression (HP:0002176)1.26614695
79Vascular calcification (HP:0004934)1.26351073
80Emphysema (HP:0002097)1.26059370
81Male pseudohermaphroditism (HP:0000037)1.24282704
82Abnormality of vitamin B metabolism (HP:0004340)1.21433938
83Villous atrophy (HP:0011473)1.20396449
84Abnormality of small intestinal villus morphology (HP:0011472)1.20396449
85Abnormality of sodium homeostasis (HP:0010931)1.19630335
86Postaxial foot polydactyly (HP:0001830)1.19322343
87Skin rash (HP:0000988)1.18281205
88Erythema (HP:0010783)1.18214893
89Urticaria (HP:0001025)1.18153109
90Carpal bone hypoplasia (HP:0001498)1.17982196
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.17890817
92Abnormality of midbrain morphology (HP:0002418)1.17650403
93Molar tooth sign on MRI (HP:0002419)1.17650403
94Autoimmune hemolytic anemia (HP:0001890)1.17246793
95Lip pit (HP:0100267)1.17161977
96Recurrent abscess formation (HP:0002722)1.15673385
97Restrictive lung disease (HP:0002091)1.14699198
98Premature loss of primary teeth (HP:0006323)1.13413312
99Lymphopenia (HP:0001888)1.13406788
100Popliteal pterygium (HP:0009756)1.12093010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.36350602
2MST45.94021707
3EPHA24.94806040
4MST1R3.95892713
5SMG12.81474990
6STK242.69177490
7RIPK42.58028414
8ERN12.52747601
9TLK12.17657330
10MAPKAPK32.01805895
11ACVR1B1.98603974
12NME11.83353099
13TBK11.70300244
14MAP3K121.65723315
15MAP3K21.59017378
16CSK1.55482935
17PIM21.30098755
18EIF2AK31.24048922
19VRK11.19599918
20GRK61.19552314
21TYK21.19208054
22MAP4K11.18266773
23MAP3K31.16937078
24NEK91.14267965
25ARAF1.14148619
26MET1.13877284
27LRRK21.11498922
28STK101.09107597
29STK161.04640666
30BCR1.03543140
31IKBKE1.02908392
32DAPK31.01062667
33EPHB11.00505839
34TTK0.98036533
35PRKCI0.97239520
36PBK0.96421394
37EEF2K0.96365927
38PRPF4B0.94914986
39TESK10.94239115
40IRAK40.92679218
41RPS6KB20.91881361
42EIF2AK10.90619528
43RIPK10.89777050
44FGFR40.84574368
45TESK20.82262366
46BMPR20.80624174
47MATK0.79692938
48BTK0.78118434
49OXSR10.75336993
50AURKA0.72536229
51LMTK20.70481962
52PRKCD0.69684596
53PAK40.68935950
54MAP3K100.67350570
55PRKG20.65656027
56BLK0.64878619
57TRIB30.64811181
58PDPK10.63391470
59JAK10.60728091
60PRKCQ0.59517714
61NEK60.58548512
62MAP3K130.57735518
63MAP3K140.53816296
64MAP3K80.53353537
65MAPK110.53337556
66PTK2B0.53192331
67EPHA30.52348524
68PTK60.51977479
69RPS6KA50.51053125
70LYN0.50260817
71PIM10.48923454
72SYK0.48234769
73ICK0.47219508
74STK40.47110076
75MAP2K20.46384363
76MYLK0.45976624
77FGFR30.45310486
78IKBKB0.45086926
79CSF1R0.43260007
80PDK10.41908924
81CCNB10.41526894
82AKT20.39519907
83NME20.38767896
84PAK10.38169545
85ZAP700.36226324
86MAP3K10.35359410
87MELK0.35086772
88CDK90.34031155
89ILK0.33713685
90CAMK2G0.31891476
91ERBB20.31561326
92STK390.31174157
93MAPKAPK50.27527996
94TAOK10.27521615
95AURKB0.27195726
96DAPK10.25355089
97MAPKAPK20.25224396
98PDK20.24511963
99VRK20.23796146
100BRAF0.23788919

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.83396747
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.47098065
3Chemical carcinogenesis_Homo sapiens_hsa052043.35311441
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.26642689
5Phenylalanine metabolism_Homo sapiens_hsa003603.21202949
6Histidine metabolism_Homo sapiens_hsa003402.99227614
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.74280337
8Systemic lupus erythematosus_Homo sapiens_hsa053222.60894522
9Caffeine metabolism_Homo sapiens_hsa002322.53785430
10Allograft rejection_Homo sapiens_hsa053302.52436630
11Autoimmune thyroid disease_Homo sapiens_hsa053202.39315469
12Retinol metabolism_Homo sapiens_hsa008302.35185397
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.34210559
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25551450
15Tyrosine metabolism_Homo sapiens_hsa003502.22189976
16Vitamin digestion and absorption_Homo sapiens_hsa049772.16441005
17Asthma_Homo sapiens_hsa053102.14417798
18Graft-versus-host disease_Homo sapiens_hsa053322.11514591
19Drug metabolism - other enzymes_Homo sapiens_hsa009832.01053604
20Glutathione metabolism_Homo sapiens_hsa004801.91402945
21Starch and sucrose metabolism_Homo sapiens_hsa005001.89424635
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88726790
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.87782256
24Type I diabetes mellitus_Homo sapiens_hsa049401.77299806
25Fat digestion and absorption_Homo sapiens_hsa049751.48551339
26Renin-angiotensin system_Homo sapiens_hsa046141.46646708
27Fructose and mannose metabolism_Homo sapiens_hsa000511.45059845
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39628457
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30453814
30Alcoholism_Homo sapiens_hsa050341.29675724
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28979565
32Linoleic acid metabolism_Homo sapiens_hsa005911.27490086
33Antigen processing and presentation_Homo sapiens_hsa046121.19392720
34Sulfur metabolism_Homo sapiens_hsa009201.18124497
35beta-Alanine metabolism_Homo sapiens_hsa004101.17272110
36Fatty acid degradation_Homo sapiens_hsa000711.15758699
37Viral myocarditis_Homo sapiens_hsa054161.14615246
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14613723
39Primary immunodeficiency_Homo sapiens_hsa053401.10992793
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07097931
41Arachidonic acid metabolism_Homo sapiens_hsa005901.06769299
42Arginine biosynthesis_Homo sapiens_hsa002201.05455285
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02323674
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02055057
45Huntingtons disease_Homo sapiens_hsa050161.01267607
46Galactose metabolism_Homo sapiens_hsa000520.93297518
47PPAR signaling pathway_Homo sapiens_hsa033200.93004530
48Staphylococcus aureus infection_Homo sapiens_hsa051500.88201548
49Sphingolipid metabolism_Homo sapiens_hsa006000.87763314
50Hepatitis C_Homo sapiens_hsa051600.85373189
51Mineral absorption_Homo sapiens_hsa049780.84605428
52Influenza A_Homo sapiens_hsa051640.77892224
53Peroxisome_Homo sapiens_hsa041460.77539048
54Hematopoietic cell lineage_Homo sapiens_hsa046400.70484282
55Leishmaniasis_Homo sapiens_hsa051400.69199509
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67732404
57Pentose phosphate pathway_Homo sapiens_hsa000300.64250638
58B cell receptor signaling pathway_Homo sapiens_hsa046620.63397974
59Arginine and proline metabolism_Homo sapiens_hsa003300.61308902
60Viral carcinogenesis_Homo sapiens_hsa052030.59662810
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58142306
62Herpes simplex infection_Homo sapiens_hsa051680.57827483
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55217026
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52477897
65Bile secretion_Homo sapiens_hsa049760.50902061
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49990371
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.49052670
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49004419
69Protein digestion and absorption_Homo sapiens_hsa049740.48034493
70N-Glycan biosynthesis_Homo sapiens_hsa005100.42764075
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41801616
72Tryptophan metabolism_Homo sapiens_hsa003800.40203581
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38730352
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37436345
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35676785
76Glycerolipid metabolism_Homo sapiens_hsa005610.34881809
77Apoptosis_Homo sapiens_hsa042100.34261472
78Rheumatoid arthritis_Homo sapiens_hsa053230.33991601
79ABC transporters_Homo sapiens_hsa020100.33408402
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33015496
81Toxoplasmosis_Homo sapiens_hsa051450.32869218
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30321458
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29743201
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28754876
85Measles_Homo sapiens_hsa051620.28727109
86Metabolic pathways_Homo sapiens_hsa011000.25969118
87Tight junction_Homo sapiens_hsa045300.24264402
88Phagosome_Homo sapiens_hsa041450.23546664
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.23430115
90Carbon metabolism_Homo sapiens_hsa012000.21532823
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.20470848
92Tuberculosis_Homo sapiens_hsa051520.19889362
93Vibrio cholerae infection_Homo sapiens_hsa051100.19336859
94Pyruvate metabolism_Homo sapiens_hsa006200.19125731
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18397847
96Biosynthesis of amino acids_Homo sapiens_hsa012300.16403402
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16366337
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.16353127
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15115268
100Ribosome_Homo sapiens_hsa030100.08128724

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