HRASLS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.82895757
2spermatid development (GO:0007286)9.66521629
3motile cilium assembly (GO:0044458)9.41312223
4reproduction (GO:0000003)9.30250857
5low-density lipoprotein particle clearance (GO:0034383)8.72025752
6regulation of cilium movement (GO:0003352)8.14503942
7piRNA metabolic process (GO:0034587)8.13123759
8cilium movement (GO:0003341)8.11935071
9triglyceride catabolic process (GO:0019433)7.85803171
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.83631322
11male meiosis (GO:0007140)7.74241888
12synaptonemal complex organization (GO:0070193)7.67743297
13synaptonemal complex assembly (GO:0007130)7.56494969
14single fertilization (GO:0007338)7.34702288
15sperm capacitation (GO:0048240)7.03235359
16negative regulation of inclusion body assembly (GO:0090084)6.95360810
17neutral lipid catabolic process (GO:0046461)6.89480598
18acylglycerol catabolic process (GO:0046464)6.89480598
19spermatogenesis (GO:0007283)6.64234063
20male gamete generation (GO:0048232)6.61845537
21transcytosis (GO:0045056)6.61695309
22regulation of sequestering of triglyceride (GO:0010889)6.54640467
23fertilization (GO:0009566)6.31714937
24organic cation transport (GO:0015695)6.20113829
25microtubule depolymerization (GO:0007019)6.15767471
26gamete generation (GO:0007276)6.08116009
27response to dietary excess (GO:0002021)6.02629413
28regulation of inclusion body assembly (GO:0090083)5.76009210
29germ cell development (GO:0007281)5.44222265
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.42231069
31calcium ion-dependent exocytosis (GO:0017156)5.38470346
32fatty acid homeostasis (GO:0055089)5.31391182
33DNA methylation involved in gamete generation (GO:0043046)5.22240858
34chromosome organization involved in meiosis (GO:0070192)5.19762185
35glycerolipid catabolic process (GO:0046503)5.17011146
36ventricular system development (GO:0021591)5.12200470
37male meiosis I (GO:0007141)5.07291213
38cell recognition (GO:0008037)5.06334144
39regulation of glycogen (starch) synthase activity (GO:2000465)5.00192344
40seminiferous tubule development (GO:0072520)4.97856988
41chromosome condensation (GO:0030261)4.88911184
42spermatid nucleus differentiation (GO:0007289)4.87902538
43microtubule severing (GO:0051013)4.84710039
44regulation of microtubule-based movement (GO:0060632)4.81039607
45regulation of cAMP-dependent protein kinase activity (GO:2000479)4.79115236
46multicellular organismal reproductive process (GO:0048609)4.77234695
47protein heterotrimerization (GO:0070208)4.70779263
48ovulation from ovarian follicle (GO:0001542)4.69542634
49glycerol ether metabolic process (GO:0006662)4.69174710
50DNA packaging (GO:0006323)4.65312992
51regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.55120184
52meiotic nuclear division (GO:0007126)4.52688234
53white fat cell differentiation (GO:0050872)4.41460241
54ether metabolic process (GO:0018904)4.33527409
55negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.31284127
56NADH metabolic process (GO:0006734)4.30945775
57lipid storage (GO:0019915)4.26628324
58diacylglycerol metabolic process (GO:0046339)4.26053165
59left/right pattern formation (GO:0060972)4.18019424
60chaperone-mediated protein complex assembly (GO:0051131)4.16259306
61positive regulation of glomerulus development (GO:0090193)4.10190486
62meiosis I (GO:0007127)4.06759967
63positive regulation of insulin receptor signaling pathway (GO:0046628)4.04385785
64negative regulation of amino acid transport (GO:0051956)4.03506081
65positive regulation of cellular response to insulin stimulus (GO:1900078)3.97118263
66plasma lipoprotein particle clearance (GO:0034381)3.95072483
67ethanol oxidation (GO:0006069)3.94787906
68lipid particle organization (GO:0034389)3.94423444
69negative regulation of granulocyte differentiation (GO:0030853)3.87977206
70multicellular organismal development (GO:0007275)3.87363260
71paraxial mesoderm development (GO:0048339)3.86101923
72sequestering of actin monomers (GO:0042989)3.80759118
73genitalia morphogenesis (GO:0035112)3.77418358
74sexual reproduction (GO:0019953)3.77177389
75brown fat cell differentiation (GO:0050873)3.74968421
76polyol transport (GO:0015791)3.74268398
77single strand break repair (GO:0000012)3.72731474
78meiotic cell cycle (GO:0051321)3.71205155
79regulation of gonadotropin secretion (GO:0032276)3.69641196
80negative regulation of metanephros development (GO:0072217)3.65872260
81monoubiquitinated protein deubiquitination (GO:0035520)3.65860254
82protein localization to cilium (GO:0061512)3.60036824
83protein polyglutamylation (GO:0018095)3.58809232
84negative regulation of macrophage differentiation (GO:0045650)3.55944428
85CDP-diacylglycerol metabolic process (GO:0046341)3.55843858
86regulation of cholesterol storage (GO:0010885)3.52723949
87protein K11-linked deubiquitination (GO:0035871)3.52394164
88triglyceride biosynthetic process (GO:0019432)3.52203420
89positive regulation of glucose import (GO:0046326)3.46876534
90rRNA modification (GO:0000154)3.38275942
91biotin metabolic process (GO:0006768)3.35179515
92negative regulation of DNA biosynthetic process (GO:2000279)3.34412198
93positive regulation of lipid storage (GO:0010884)3.33221632
94negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.33020133
95acylglycerol biosynthetic process (GO:0046463)3.31737427
96neutral lipid biosynthetic process (GO:0046460)3.31737427
97regulation of spindle checkpoint (GO:0090231)3.29957630
98positive regulation of SMAD protein import into nucleus (GO:0060391)3.29619508
99retina vasculature morphogenesis in camera-type eye (GO:0061299)3.28178042
100rRNA methylation (GO:0031167)3.24509463
101CDP-diacylglycerol biosynthetic process (GO:0016024)3.23204198
102lung-associated mesenchyme development (GO:0060484)3.21464408
103positive regulation of glucose transport (GO:0010828)3.21376745
104negative regulation of protein autophosphorylation (GO:0031953)3.19858531
105positive regulation of triglyceride lipase activity (GO:0061365)3.19606744
106positive regulation of lipoprotein lipase activity (GO:0051006)3.19606744
107triglyceride metabolic process (GO:0006641)3.19390553
108carnitine transport (GO:0015879)3.18911291
109amino-acid betaine transport (GO:0015838)3.18911291
110positive regulation of cholesterol efflux (GO:0010875)3.18546524
111acylglycerol homeostasis (GO:0055090)3.17602423
112triglyceride homeostasis (GO:0070328)3.17602423
113response to phenylpropanoid (GO:0080184)3.16565456
114regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.14196097
115microtubule polymerization or depolymerization (GO:0031109)3.13335855
116protein refolding (GO:0042026)3.11481390
117nucleoside diphosphate phosphorylation (GO:0006165)3.11211444
118alditol metabolic process (GO:0019400)3.09549031
119polyol catabolic process (GO:0046174)3.09274095
120regulation of protein kinase A signaling (GO:0010738)3.08434624
121negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.07685439
122carnitine transmembrane transport (GO:1902603)3.07585811
123mitotic sister chromatid cohesion (GO:0007064)3.06688982
124synapsis (GO:0007129)3.06240829
125negative regulation of cardiac muscle tissue growth (GO:0055022)3.05711519
126negative regulation of heart growth (GO:0061117)3.05711519
127cGMP-mediated signaling (GO:0019934)3.05073143
128glycolytic process (GO:0006096)3.02165351
129protein localization to cell surface (GO:0034394)3.01820514
130cell migration involved in gastrulation (GO:0042074)3.00974893
131intraciliary transport (GO:0042073)3.00063164
132GTP biosynthetic process (GO:0006183)2.98871775
133meiotic cell cycle process (GO:1903046)2.97493501
134primary alcohol metabolic process (GO:0034308)2.97448847
135cellular response to leptin stimulus (GO:0044320)2.95736306
136regulation of glomerulus development (GO:0090192)2.94379845
137positive regulation of glycolytic process (GO:0045821)2.94105958
138nucleus organization (GO:0006997)2.92350206
139interferon-gamma secretion (GO:0072643)2.91900605
140lactate metabolic process (GO:0006089)2.91071038
141gene silencing by RNA (GO:0031047)2.90142000
142acylglycerol metabolic process (GO:0006639)2.90135877
143microtubule-based movement (GO:0007018)2.89174791
144negative regulation of cartilage development (GO:0061037)2.88856603
145adult feeding behavior (GO:0008343)2.88764775
146regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.88681934
147axoneme assembly (GO:0035082)2.88092674
148negative regulation of response to food (GO:0032096)2.87469234
149negative regulation of appetite (GO:0032099)2.87469234
150ethanol metabolic process (GO:0006067)2.86864276
151cellular response to epinephrine stimulus (GO:0071872)2.86783596
152regulation of transforming growth factor beta2 production (GO:0032909)2.84796460
153neutral lipid metabolic process (GO:0006638)2.84387217
154cilium organization (GO:0044782)2.83825059
155negative regulation of organelle assembly (GO:1902116)2.82365144
156tricarboxylic acid metabolic process (GO:0072350)2.82173766
157endothelial cell morphogenesis (GO:0001886)2.79625052
158chaperone-mediated protein transport (GO:0072321)2.78223083
159tyrosine phosphorylation of STAT protein (GO:0007260)2.77593997
160positive regulation of macrophage activation (GO:0043032)2.77380863
161cilium morphogenesis (GO:0060271)2.76953832
162phagocytosis, recognition (GO:0006910)2.75497245
163regulation of retinoic acid receptor signaling pathway (GO:0048385)2.75227694
164cellular component assembly involved in morphogenesis (GO:0010927)2.75152326
165cAMP biosynthetic process (GO:0006171)2.74319977
166response to epinephrine (GO:0071871)2.74009463
167regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.73820215
168negative regulation of phagocytosis (GO:0050765)2.71998222
169cilium assembly (GO:0042384)2.70911321
170cellular response to lithium ion (GO:0071285)2.70657533
171regulation of lipoprotein metabolic process (GO:0050746)2.69147910
172UTP biosynthetic process (GO:0006228)2.66548771
173glycerol metabolic process (GO:0006071)2.65851227
174regulation of cilium assembly (GO:1902017)2.55444919
175peptidyl-glutamic acid modification (GO:0018200)2.49644967
176RNA localization (GO:0006403)2.49215636
177gene silencing (GO:0016458)2.49051312
178UTP metabolic process (GO:0046051)2.42876949
179centriole assembly (GO:0098534)2.41985433
180sperm motility (GO:0030317)13.5501832
181fusion of sperm to egg plasma membrane (GO:0007342)13.4285546
182cell wall macromolecule metabolic process (GO:0044036)12.6054700
183cell wall macromolecule catabolic process (GO:0016998)12.6054700
184acrosome assembly (GO:0001675)12.3429447
185acrosome reaction (GO:0007340)11.7626458
186sperm-egg recognition (GO:0035036)11.6856884
187multicellular organism reproduction (GO:0032504)10.8827184
188binding of sperm to zona pellucida (GO:0007339)10.7926125
189cell-cell recognition (GO:0009988)10.4621113
190cilium or flagellum-dependent cell motility (GO:0001539)10.3089477
191plasma membrane fusion (GO:0045026)10.2270375
192axonemal dynein complex assembly (GO:0070286)10.0312257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.58673737
2EZH2_22144423_ChIP-Seq_EOC_Human4.63593873
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.42164942
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.23252309
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.23252309
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.23252309
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.92299362
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.23145749
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19440336
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.07632824
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81900665
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80780801
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44303618
14ZNF274_21170338_ChIP-Seq_K562_Hela2.23342473
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.21884933
16VDR_22108803_ChIP-Seq_LS180_Human2.19112152
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18215203
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15619684
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.11500178
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.11402177
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08984124
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05807621
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.1389881
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98935250
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.92862525
26CLOCK_20551151_ChIP-Seq_293T_Human1.89640639
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86049888
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84435355
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.83887149
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78362372
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.76667928
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69401402
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69156498
34FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67395077
35* STAT1_17558387_ChIP-Seq_HELA_Human1.61373565
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58093472
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56198948
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55906924
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54774746
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54117006
41MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53553487
42GATA3_21867929_ChIP-Seq_CD8_Mouse1.53440766
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50559405
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.47747919
45KDM2B_26808549_Chip-Seq_REH_Human1.43292787
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42702201
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.42292560
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.40990312
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37012715
50CBP_20019798_ChIP-Seq_JUKART_Human1.35565808
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35565808
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33299465
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33088354
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32108426
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31870092
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31221891
57LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30969861
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.30155901
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30029092
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29872056
61P53_21459846_ChIP-Seq_SAOS-2_Human1.29728019
62REST_21632747_ChIP-Seq_MESCs_Mouse1.28800051
63PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.27535785
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27410688
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26376719
66GATA3_21867929_ChIP-Seq_TH1_Mouse1.24347457
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.23539731
68* CBP_21632823_ChIP-Seq_H3396_Human1.20597158
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20520263
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19847875
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19699195
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19524296
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19394478
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19168133
75* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18890365
76* CTCF_27219007_Chip-Seq_Bcells_Human1.17633460
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17199322
78GF1_26923725_Chip-Seq_HPCs_Mouse1.17135530
79CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17059792
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.15443203
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.14621756
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14596109
83SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13845097
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13105038
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12641859
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12498282
87* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11445828
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11281057
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10935028
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09818256
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09485291
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09485291
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.09298289
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.08647638
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.08519178
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07961555
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07675579
98SPI1_26923725_Chip-Seq_HPCs_Mouse1.06585217
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.05464164
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05366589
101PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04571945
102ERG_20517297_ChIP-Seq_VCAP_Human1.03839458
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03827583
104ESET_19884257_ChIP-Seq_ESCs_Mouse1.03356354
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03049150
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02833241
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.02827890
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02649196
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02611454
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02177845
111RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02018457
112MYC_27129775_Chip-Seq_CORNEA_Mouse1.00575020
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99561060
114SMC4_20622854_ChIP-Seq_HELA_Human0.99340996
115OCT4_18555785_Chip-Seq_ESCs_Mouse0.99328859
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.99177796
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.98674749
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98637175
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.98450422
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.98450422
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98424116
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.98418316
123TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98103674
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97918010
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.96707620
126SA1_22415368_ChIP-Seq_MEFs_Mouse0.96594577
127NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96384441
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96099322
129* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96059144
130* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96059144
131P53_22387025_ChIP-Seq_ESCs_Mouse0.95967699
132RNF2_27304074_Chip-Seq_NSC_Mouse0.95725371
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95707106
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95692675
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95457614
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.95301427
137GATA3_21878914_ChIP-Seq_MCF-7_Human0.95255401
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95188699
139RXR_22158963_ChIP-Seq_LIVER_Mouse0.95141621
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94714313
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94503613
142SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94269940
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.92975164
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92840568
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92591001
146FLI1_21867929_ChIP-Seq_CD8_Mouse0.90864429
147* ERA_21632823_ChIP-Seq_H3396_Human0.90803485
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90450270
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90098761
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.89578796
151P300_18555785_Chip-Seq_ESCs_Mouse0.89460789
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89025120
153KLF4_18555785_Chip-Seq_ESCs_Mouse0.89012770
154* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88873238
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.88751324
156KLF4_19829295_ChIP-Seq_ESCs_Human0.88368458
157TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88358453
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88137730
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88024529
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.87549689
161ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87206575
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87091931
163JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87073994
164KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86965090
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.86687928
166SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86652108
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86631663
168TAF15_26573619_Chip-Seq_HEK293_Human0.86319591
169P300_19829295_ChIP-Seq_ESCs_Human0.85964822
170BCAT_22108803_ChIP-Seq_LS180_Human0.84796428
171EOMES_21245162_ChIP-Seq_HESCs_Human0.84697475
172FOXH1_21741376_ChIP-Seq_ESCs_Human0.82776945
173NANOG_20526341_ChIP-Seq_ESCs_Human0.82554764
174SMAD4_21741376_ChIP-Seq_HESCs_Human0.82347223
175CTCF_20526341_ChIP-Seq_ESCs_Human0.82248141
176SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81247001
177CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81229172
178NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81175456
179NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80837431
180NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80801507
181HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80215571
182POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79860351
183PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79436899
184SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78753779
185PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77323671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08447751
2MP0001929_abnormal_gametogenesis5.62527799
3MP0008877_abnormal_DNA_methylation4.43803781
4MP0004185_abnormal_adipocyte_glucose4.24202312
5MP0004130_abnormal_muscle_cell3.58292146
6MP0002210_abnormal_sex_determination3.52792879
7MP0002161_abnormal_fertility/fecundity3.29736329
8MP0001145_abnormal_male_reproductive2.99399308
9MP0003186_abnormal_redox_activity2.65662669
10MP0000653_abnormal_sex_gland2.58884056
11MP0005670_abnormal_white_adipose2.55700775
12MP0002653_abnormal_ependyma_morphology2.39232107
13MP0003959_abnormal_lean_body2.34589230
14MP0010329_abnormal_lipoprotein_level2.32648635
15MP0002876_abnormal_thyroid_physiology2.14509824
16MP0002970_abnormal_white_adipose2.01933823
17MP0005334_abnormal_fat_pad2.00922616
18MP0005410_abnormal_fertilization16.3815796
19MP0000003_abnormal_adipose_tissue1.95017935
20MP0006138_congestive_heart_failure1.94039597
21MP0005379_endocrine/exocrine_gland_phen1.91785097
22MP0005503_abnormal_tendon_morphology1.82819326
23MP0002909_abnormal_adrenal_gland1.75903664
24MP0003828_pulmonary_edema1.75638600
25MP0003890_abnormal_embryonic-extraembry1.73565648
26MP0002160_abnormal_reproductive_system1.72869372
27MP0002796_impaired_skin_barrier1.66926825
28MP0005535_abnormal_body_temperature1.65181402
29MP0005275_abnormal_skin_tensile1.58075758
30MP0005623_abnormal_meninges_morphology1.51440881
31MP0004215_abnormal_myocardial_fiber1.51416058
32MP0003646_muscle_fatigue1.46705706
33MP0006276_abnormal_autonomic_nervous1.46008105
34MP0003690_abnormal_glial_cell1.45909050
35MP0003718_maternal_effect1.40122933
36MP0005448_abnormal_energy_balance1.37887024
37MP0004233_abnormal_muscle_weight1.33795631
38MP0002118_abnormal_lipid_homeostasis1.29240474
39MP0002108_abnormal_muscle_morphology1.28642534
40MP0005423_abnormal_somatic_nervous1.26859393
41MP0002638_abnormal_pupillary_reflex1.26310035
42MP0005452_abnormal_adipose_tissue1.25328031
43MP0008438_abnormal_cutaneous_collagen1.18449902
44MP0001544_abnormal_cardiovascular_syste1.18267225
45MP0005385_cardiovascular_system_phenoty1.18267225
46MP0002282_abnormal_trachea_morphology1.15389545
47MP0003868_abnormal_feces_composition1.13525945
48MP0004272_abnormal_basement_membrane1.12790594
49MP0009672_abnormal_birth_weight1.09927852
50MP0001881_abnormal_mammary_gland1.09692864
51MP0002254_reproductive_system_inflammat1.09472661
52MP0009379_abnormal_foot_pigmentation1.09352761
53MP0001765_abnormal_ion_homeostasis1.05392806
54MP0008058_abnormal_DNA_repair1.03763137
55MP0001984_abnormal_olfaction1.03762198
56MP0005647_abnormal_sex_gland1.00872878
57MP0002127_abnormal_cardiovascular_syste0.90671351
58MP0002234_abnormal_pharynx_morphology0.89822816
59MP0003119_abnormal_digestive_system0.89332276
60MP0005595_abnormal_vascular_smooth0.87985877
61MP0009046_muscle_twitch0.87751561
62MP0003567_abnormal_fetal_cardiomyocyte0.86248480
63MP0005389_reproductive_system_phenotype0.86201794
64MP0003011_delayed_dark_adaptation0.85871958
65MP0008057_abnormal_DNA_replication0.85863493
66MP0003705_abnormal_hypodermis_morpholog0.85700779
67MP0004087_abnormal_muscle_fiber0.84223759
68MP0010030_abnormal_orbit_morphology0.82715470
69MP0002078_abnormal_glucose_homeostasis0.80496860
70MP0010630_abnormal_cardiac_muscle0.80283192
71MP0005167_abnormal_blood-brain_barrier0.78731570
72MP0008995_early_reproductive_senescence0.76937212
73MP0003693_abnormal_embryo_hatching0.74013669
74MP0004084_abnormal_cardiac_muscle0.72738685
75MP0001177_atelectasis0.71638665
76MP0005620_abnormal_muscle_contractility0.69873231
77MP0001879_abnormal_lymphatic_vessel0.69623059
78MP0010094_abnormal_chromosome_stability0.68919970
79MP0004957_abnormal_blastocyst_morpholog0.66564401
80MP0005584_abnormal_enzyme/coenzyme_acti0.65830021
81MP0003137_abnormal_impulse_conducting0.65655293
82MP0002972_abnormal_cardiac_muscle0.63574480
83MP0000759_abnormal_skeletal_muscle0.62234806
84MP0003115_abnormal_respiratory_system0.60500763
85MP0001501_abnormal_sleep_pattern0.60311928
86MP0005508_abnormal_skeleton_morphology0.58545867
87MP0001440_abnormal_grooming_behavior0.58093797
88MP0005636_abnormal_mineral_homeostasis0.57805079
89MP0008775_abnormal_heart_ventricle0.56631121
90MP0005501_abnormal_skin_physiology0.56281308
91MP0000230_abnormal_systemic_arterial0.56222410
92MP0000569_abnormal_digit_pigmentation0.55197768
93MP0003329_amyloid_beta_deposits0.54417567
94MP0000749_muscle_degeneration0.54271915
95MP0000343_altered_response_to0.54137015
96MP0000566_synostosis0.53589420
97MP0000358_abnormal_cell_content/0.52999124
98MP0004036_abnormal_muscle_relaxation0.52581303
99MP0005666_abnormal_adipose_tissue0.51937992
100MP0005380_embryogenesis_phenotype0.51658886
101MP0005397_hematopoietic_system_phenotyp0.51641919
102MP0001545_abnormal_hematopoietic_system0.51641919
103MP0005377_hearing/vestibular/ear_phenot0.51482837
104MP0003878_abnormal_ear_physiology0.51482837
105MP0003724_increased_susceptibility_to0.50956339
106MP0004085_abnormal_heartbeat0.50430131
107MP0002933_joint_inflammation0.49107635
108MP0003953_abnormal_hormone_level0.47999395
109MP0001986_abnormal_taste_sensitivity0.47237123
110MP0001324_abnormal_eye_pigmentation0.47167373
111MP0003699_abnormal_female_reproductive0.46137600
112MP0008007_abnormal_cellular_replicative0.45055098
113MP0003786_premature_aging0.45021650
114MP0009278_abnormal_bone_marrow0.43757764
115MP0006036_abnormal_mitochondrial_physio0.42486090
116MP0002269_muscular_atrophy0.41688671
117MP0002928_abnormal_bile_duct0.41617388
118MP0003950_abnormal_plasma_membrane0.41449898
119MP0001764_abnormal_homeostasis0.41220188
120MP0001293_anophthalmia0.40630504
121MP0005253_abnormal_eye_physiology0.40607960
122MP0002736_abnormal_nociception_after0.38445723
123MP0005551_abnormal_eye_electrophysiolog0.38342987
124MP0003111_abnormal_nucleus_morphology0.34437366
125MP0004019_abnormal_vitamin_homeostasis0.33196937
126MP0004133_heterotaxia0.32637469
127MP0001730_embryonic_growth_arrest0.32341691
128MP0010307_abnormal_tumor_latency0.31948272
129MP0009115_abnormal_fat_cell0.31737415
130MP0005391_vision/eye_phenotype0.31109974
131MP0000534_abnormal_ureter_morphology0.30561715
132MP0001119_abnormal_female_reproductive0.29895277
133MP0004808_abnormal_hematopoietic_stem0.28978078
134MP0003633_abnormal_nervous_system0.28028854
135MP0002971_abnormal_brown_adipose0.27850586
136MP0000604_amyloidosis0.27766333
137MP0002139_abnormal_hepatobiliary_system0.27724869
138MP0004811_abnormal_neuron_physiology0.27270077
139MP0004134_abnormal_chest_morphology0.24734912
140MP0003861_abnormal_nervous_system0.23997545
141MP0003631_nervous_system_phenotype0.21997906
142MP0002152_abnormal_brain_morphology0.21782400
143MP0001727_abnormal_embryo_implantation0.21759592
144MP0002169_no_abnormal_phenotype0.21171550
145MP0003942_abnormal_urinary_system0.21073829
146MP0006035_abnormal_mitochondrial_morpho0.20937721
147MP0002873_normal_phenotype0.20933436
148MP0003879_abnormal_hair_cell0.20490358
149MP0000313_abnormal_cell_death0.19148586
150MP0003948_abnormal_gas_homeostasis0.19016772
151MP0002102_abnormal_ear_morphology0.18904119
152MP0001968_abnormal_touch/_nociception0.18062765
153MP0002092_abnormal_eye_morphology0.16531610
154MP0008961_abnormal_basal_metabolism0.15648138
155MP0001849_ear_inflammation0.15640749
156MP0002084_abnormal_developmental_patter0.15401297
157MP0002295_abnormal_pulmonary_circulatio0.15057250
158MP0004043_abnormal_pH_regulation0.15001466
159MP0001661_extended_life_span0.14830419
160MP0006072_abnormal_retinal_apoptosis0.14674270
161MP0000751_myopathy0.14606722
162MP0002229_neurodegeneration0.14064296
163MP0000001_mammalian_phenotype0.13771715
164MP0005375_adipose_tissue_phenotype0.12995120
165MP0004145_abnormal_muscle_electrophysio0.12831323
166MP0008875_abnormal_xenobiotic_pharmacok0.12211442
167MP0004742_abnormal_vestibular_system0.12050111
168MP0005195_abnormal_posterior_eye0.11595997
169MP0003045_fibrosis0.11518664
170MP0005365_abnormal_bile_salt0.11191657
171MP0005319_abnormal_enzyme/_coenzyme0.11118401
172MP0001672_abnormal_embryogenesis/_devel0.10905222

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.62945375
2Abnormal respiratory motile cilium morphology (HP:0005938)9.25960872
3Abnormal respiratory epithelium morphology (HP:0012253)9.25960872
4Oligomenorrhea (HP:0000876)8.31735101
5Rhinitis (HP:0012384)7.77890742
6Abnormal ciliary motility (HP:0012262)7.67761195
7Chronic bronchitis (HP:0004469)7.65938358
8Infertility (HP:0000789)6.85471822
9Nasal polyposis (HP:0100582)6.48831472
10Acanthosis nigricans (HP:0000956)6.03023014
11Abnormality of the nasal mucosa (HP:0000433)5.33730437
12Hypertriglyceridemia (HP:0002155)5.01401132
13Bronchitis (HP:0012387)4.59128785
14Bronchiectasis (HP:0002110)4.50299396
15Insulin resistance (HP:0000855)4.39732284
16Nephronophthisis (HP:0000090)4.16592608
17Male infertility (HP:0003251)4.15180295
18Insulin-resistant diabetes mellitus (HP:0000831)3.89323411
19Abnormal eating behavior (HP:0100738)3.69085510
20Recurrent sinusitis (HP:0011108)3.45683334
21Increased variability in muscle fiber diameter (HP:0003557)3.43257478
22Abnormality of the labia minora (HP:0012880)3.36440555
23Long foot (HP:0001833)3.34706419
24Fused cervical vertebrae (HP:0002949)3.33601443
25Recurrent otitis media (HP:0000403)3.31557231
26Abnormal spermatogenesis (HP:0008669)3.30535959
27Subcapsular cataract (HP:0000523)3.15013263
28Abnormality of the renal medulla (HP:0100957)3.14408951
29Polyphagia (HP:0002591)3.14120973
30Hypophosphatemic rickets (HP:0004912)3.00015346
31Abnormality of abdominal situs (HP:0011620)2.89475758
32Abdominal situs inversus (HP:0003363)2.89475758
33Difficulty running (HP:0009046)2.84548677
34Abnormal hemoglobin (HP:0011902)2.81485309
35Maternal diabetes (HP:0009800)2.78254043
36Septo-optic dysplasia (HP:0100842)2.77623575
37Tubulointerstitial nephritis (HP:0001970)2.75582812
38Abnormality of skeletal muscle fiber size (HP:0012084)2.75288208
39Protrusio acetabuli (HP:0003179)2.62204793
40Stenosis of the external auditory canal (HP:0000402)2.61188899
41Molar tooth sign on MRI (HP:0002419)2.58942367
42Abnormality of midbrain morphology (HP:0002418)2.58942367
43Hypoglycemic seizures (HP:0002173)2.57135559
44Gonadotropin excess (HP:0000837)2.56606895
45Recurrent bronchitis (HP:0002837)2.54589070
46Muscle fiber splitting (HP:0003555)2.54059014
47Coronal craniosynostosis (HP:0004440)2.52096626
48Tubular atrophy (HP:0000092)2.49825350
49Myocardial infarction (HP:0001658)2.48321786
50Ileus (HP:0002595)2.47248929
51Abnormal pancreas size (HP:0012094)2.47088531
52Medial flaring of the eyebrow (HP:0010747)2.46101033
53Nausea (HP:0002018)2.38632675
54Multiple enchondromatosis (HP:0005701)2.38544404
55Tubulointerstitial abnormality (HP:0001969)2.37994573
56Choanal stenosis (HP:0000452)2.37229893
57Impulsivity (HP:0100710)2.36315866
58Prominent supraorbital ridges (HP:0000336)2.34645208
59Inability to walk (HP:0002540)2.33444271
60Patent foramen ovale (HP:0001655)2.23766528
61Azoospermia (HP:0000027)2.22808617
62Abnormal ventriculo-arterial connection (HP:0011563)2.19916908
63Transposition of the great arteries (HP:0001669)2.19916908
64Abnormal connection of the cardiac segments (HP:0011545)2.19916908
65Pigmentary retinal degeneration (HP:0001146)2.19164010
66Absent septum pellucidum (HP:0001331)2.15846231
67Back pain (HP:0003418)2.15345697
68Abnormality of the lower motor neuron (HP:0002366)2.14583577
69Increased serum pyruvate (HP:0003542)2.13411219
70Hypercortisolism (HP:0001578)2.13205765
71Polar cataract (HP:0010696)2.13086625
72Accelerated skeletal maturation (HP:0005616)2.12912478
73Shallow orbits (HP:0000586)2.12447486
74Abnormality of the septum pellucidum (HP:0007375)2.10131705
75Ectopia lentis (HP:0001083)2.09462785
76Rickets (HP:0002748)2.07980718
77Abnormality of the aortic arch (HP:0012303)2.07739357
78Premature rupture of membranes (HP:0001788)2.07159853
79Cholecystitis (HP:0001082)2.03123456
80Abnormal gallbladder physiology (HP:0012438)2.03123456
81Spinal rigidity (HP:0003306)2.01386113
82Broad metatarsal (HP:0001783)2.01088398
83Short hallux (HP:0010109)2.00931429
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.5082779
85Dynein arm defect of respiratory motile cilia (HP:0012255)13.3979408
86Absent/shortened dynein arms (HP:0200106)13.3979408
87Abnormality of the clitoris (HP:0000056)1.99515420
88Pancreatic islet-cell hyperplasia (HP:0004510)1.97421287
89Tubulointerstitial fibrosis (HP:0005576)1.93847279
90Abnormality of the costochondral junction (HP:0000919)1.92203893
91Fibular hypoplasia (HP:0003038)1.91728411
92Neck muscle weakness (HP:0000467)1.89712399
93Hyperglycinuria (HP:0003108)1.89094347
94Resting tremor (HP:0002322)1.88159531
95Hypoglycemic coma (HP:0001325)1.87977004
96Postaxial foot polydactyly (HP:0001830)1.87210666
97Dyschromatopsia (HP:0007641)1.86538110
98Osteomalacia (HP:0002749)1.85378169
99Hyperlipoproteinemia (HP:0010980)1.85054484
100Lymphangioma (HP:0100764)1.84485210
101Nasal speech (HP:0001611)1.82382180
102Lipoatrophy (HP:0100578)1.82100609
103Stage 5 chronic kidney disease (HP:0003774)1.82043421
104Hypercholesterolemia (HP:0003124)1.80792253
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80433161
106Metaphyseal dysplasia (HP:0100255)1.78291446
107Amyotrophic lateral sclerosis (HP:0007354)1.77813590
108Hypoalphalipoproteinemia (HP:0003233)1.76816181
109Neonatal hypoglycemia (HP:0001998)1.76626856
110Short tibia (HP:0005736)1.76410776
111Ankle contracture (HP:0006466)1.76106168
112Hyperglycemia (HP:0003074)1.75619552
113Spastic tetraparesis (HP:0001285)1.73424399
114Clitoromegaly (HP:0000057)1.73307950
115Aplasia/Hypoplasia of the hallux (HP:0008362)1.73007875
116Abnormal drinking behavior (HP:0030082)1.72948241
117Polydipsia (HP:0001959)1.72948241
118Congenital hepatic fibrosis (HP:0002612)1.71468645
119Facial shape deformation (HP:0011334)1.70325210
120Potter facies (HP:0002009)1.70325210
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68102205
122Large hands (HP:0001176)1.67258575
123Abnormality of the renal cortex (HP:0011035)1.67247335
124Ureteral duplication (HP:0000073)1.66562425
125Paralysis (HP:0003470)1.65116004
126Abnormality of glycolysis (HP:0004366)1.64162735
127Turricephaly (HP:0000262)1.63685431
128Preauricular pit (HP:0004467)1.63123227
129Periauricular skin pits (HP:0100277)1.63123227
130Reduced subcutaneous adipose tissue (HP:0003758)1.63102774
131Generalized amyotrophy (HP:0003700)1.62085194
132Decreased central vision (HP:0007663)1.61952780
133Abnormality of renal excretion (HP:0011036)1.61564562
134Severe visual impairment (HP:0001141)1.61504314
135Sensory axonal neuropathy (HP:0003390)1.61445136
136Growth hormone excess (HP:0000845)1.61048194
137Abnormality of the dental root (HP:0006486)1.60502946
138Taurodontia (HP:0000679)1.60502946
139Abnormality of permanent molar morphology (HP:0011071)1.60502946
140Choroideremia (HP:0001139)1.59744143
141Right ventricular cardiomyopathy (HP:0011663)1.58236415
142Oculomotor apraxia (HP:0000657)1.58112045
143Short ribs (HP:0000773)1.58011332
144Rhabdomyolysis (HP:0003201)1.57675288
145Preaxial foot polydactyly (HP:0001841)1.56752375
146Hyperalaninemia (HP:0003348)1.56400983
147Renal dysplasia (HP:0000110)1.52981630
148Abnormality of dentin (HP:0010299)1.52019722
149Heterotopia (HP:0002282)1.51708860
150Abnormality of molar (HP:0011077)1.48581566
151Abnormality of molar morphology (HP:0011070)1.48581566
152Abnormality of the dental pulp (HP:0006479)1.48484191
153Impaired proprioception (HP:0010831)1.47044900
154Postaxial hand polydactyly (HP:0001162)1.45966802
155Chronic sinusitis (HP:0011109)1.44444763
156Facial cleft (HP:0002006)1.44345842
157Bile duct proliferation (HP:0001408)1.44341448
158Abnormal biliary tract physiology (HP:0012439)1.44341448
159Absent frontal sinuses (HP:0002688)1.42166154
160Aplasia/Hypoplasia of the lens (HP:0008063)1.41954337
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41915902
162Absent epiphyses (HP:0010577)1.41915902
163Bell-shaped thorax (HP:0001591)1.41267587
164Double outlet right ventricle (HP:0001719)1.38897524
165Congenital malformation of the right heart (HP:0011723)1.38897524
166Hemorrhage of the eye (HP:0011885)1.38685940
167Cystic liver disease (HP:0006706)1.38297966
168Neurofibrillary tangles (HP:0002185)1.35462500
169Deformed sella turcica (HP:0002681)1.34293609
170J-shaped sella turcica (HP:0002680)1.34115869
171Microglossia (HP:0000171)1.33677802
172Congenital primary aphakia (HP:0007707)1.33614193
173Gait imbalance (HP:0002141)1.33197529
174Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.29001618
175Asymmetric septal hypertrophy (HP:0001670)1.28374115
176Abnormal urine output (HP:0012590)1.27776726
177Exercise-induced myalgia (HP:0003738)1.26984706
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.26289536
179Pancreatic fibrosis (HP:0100732)1.25109358
180Broad distal phalanx of finger (HP:0009836)1.24396152
181Aplasia/Hypoplasia of the tongue (HP:0010295)1.22898382
182Supernumerary spleens (HP:0009799)1.22595083
183Cerebellar dysplasia (HP:0007033)1.22481500
184Bundle branch block (HP:0011710)1.21226726
185Easy fatigability (HP:0003388)1.20883686
186Short thorax (HP:0010306)1.19983588
187Nephropathy (HP:0000112)1.19450462
188Aplasia/Hypoplasia of the fibula (HP:0006492)1.17409653
189Short femoral neck (HP:0100864)1.15433637
190Abnormality of ocular smooth pursuit (HP:0000617)1.14811360
191Vascular calcification (HP:0004934)1.14460917
192Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.12695223
193Median cleft lip (HP:0000161)1.12328708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.67481388
2PDK48.67481388
3TESK15.73778894
4PDK25.62346737
5PRKD34.38740286
6ICK3.97784934
7LATS23.67219719
8DDR23.51279723
9TIE13.01473193
10PTK2B2.28501930
11WNK42.25731749
12LATS12.24878226
13PRKAA22.19679948
14STK392.19155256
15CAMK12.13339318
16ARAF1.95717246
17PNCK1.81601485
18MAP4K21.77394515
19NEK21.72876547
20STK381.72852664
21MYLK1.66416450
22MAP3K91.54355076
23CDK191.52165601
24PBK1.48280692
25BMX1.42061107
26DYRK21.41521796
27STK161.35079433
28DYRK1B1.34173849
29MST41.34084724
30EPHB21.32597318
31SGK4941.20661287
32SGK2231.20661287
33NLK1.18189076
34PDK11.16816062
35ABL21.16386174
36SRPK11.06298713
37TSSK61.03007168
38DAPK31.02609404
39MAP2K10.98083435
40GRK50.97227146
41PLK30.96848652
42LRRK20.94613942
43DMPK0.91966518
44MAPK150.89675130
45WNK10.89158929
46CAMK1D0.88425926
47DYRK30.88326545
48TYRO30.87716993
49MAPK40.85103100
50RIPK10.84476116
51KSR20.83471629
52CCNB10.81922418
53PASK0.81752976
54IRAK10.80563927
55ERBB40.78537024
56PLK20.78368155
57INSRR0.76809518
58MAP3K120.75963807
59STK30.72795253
60MAP3K80.68582074
61PDPK10.66619327
62BUB10.66281619
63MKNK20.63570519
64PINK10.62939220
65TTK0.62864390
66ROCK10.62754165
67TESK20.59951206
68AURKB0.59555139
69MKNK10.59401942
70PDGFRA0.58906289
71ADRBK10.56979128
72EEF2K0.56905500
73TGFBR20.55487746
74AKT20.54955112
75RIPK40.54404865
76CHEK20.53569289
77ROCK20.52665944
78FGFR20.51880596
79CDK40.51589499
80CDK70.51062103
81PHKG10.49924818
82PHKG20.49924818
83LMTK20.48625507
84RPS6KL10.44346551
85RPS6KC10.44346551
86SGK20.44345061
87MAP3K10.43412240
88STK38L0.43382561
89MAP2K60.43267285
90MAPK10.41995695
91MAPK120.41944610
92RPS6KA20.41049195
93MUSK0.41029910
94MAP3K130.40938371
95NTRK20.40497529
96IRAK20.40215629
97CHEK10.40039853
98MAP2K20.39137905
99CAMK1G0.38257611
100PRKCH0.36291276
101WEE10.35204116
102PAK10.33392597
103ATR0.33305146
104CDC70.32528075
105PRKCG0.32106380
106MAP3K100.29112399
107ATM0.27641047
108MAPKAPK50.27455605
109CAMKK10.26566879
110PAK20.23578418
111MTOR0.22483366
112PLK40.21332814
113MARK20.21205704
114BRSK20.19726667
115PRKAA10.18300332
116RPS6KB10.16425560
117PLK10.16080040
118PAK40.14468096
119PRKCZ0.14256245
120CDK150.13551652
121BRAF0.13176944
122PRKCQ0.12064778
123NEK60.11572699
124CDK180.11045557
125CDK11A0.09853618
126BMPR1B0.09646193
127PRKG20.08591313
128BRSK10.08075148
129MARK30.07477567
130CSF1R0.07124742
131CSNK2A10.06790795
132CDK140.06760591
133RPS6KA10.06133892
134STK100.06044575
135PRKACG0.05440430
136PRKG10.04874718
137GSK3B0.03876026
138MAPK80.02615007
139CDK10.02490827
140STK110.02176292
141CDK20.01644575
142MAP3K40.01482612
143CSNK1D0.01007747
144WNK30.00329901
145CAMK2A0.00317115
146CSNK2A20.00080030
147PRKCB-1.3820237
148PRKACA-0.0394793
149MAP3K5-0.0366051
150PRKDC-0.0264718
151RPS6KA3-0.0258562
152PDGFRB-0.0221899
153CDK6-0.0201336
154AURKA-0.0170619
155CDK12-0.0157183
156EGFR-0.0153285
157PRKACB-0.0136163
158PAK6-0.0118948
159PIM1-0.0116167
160PRKCA-0.0076778
161PRKCD-0.0068924
162ZAP70-0.0047570
163PKN1-0.0017692

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.54093194
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.42403275
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.41827756
4Fatty acid biosynthesis_Homo sapiens_hsa000614.18417958
5Pyruvate metabolism_Homo sapiens_hsa006203.91424421
6Phenylalanine metabolism_Homo sapiens_hsa003603.19074533
7Propanoate metabolism_Homo sapiens_hsa006403.07353649
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95071823
9Linoleic acid metabolism_Homo sapiens_hsa005912.85898095
10Glucagon signaling pathway_Homo sapiens_hsa049222.80705984
11Fatty acid elongation_Homo sapiens_hsa000622.55252068
12Basal transcription factors_Homo sapiens_hsa030222.44642175
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29476413
14Selenocompound metabolism_Homo sapiens_hsa004502.22914786
15beta-Alanine metabolism_Homo sapiens_hsa004102.11568829
16Pentose phosphate pathway_Homo sapiens_hsa000302.10248282
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.07124952
18Glycerolipid metabolism_Homo sapiens_hsa005611.97421979
19Tyrosine metabolism_Homo sapiens_hsa003501.93418154
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91689504
21Histidine metabolism_Homo sapiens_hsa003401.87749516
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86636772
23PPAR signaling pathway_Homo sapiens_hsa033201.82643844
24Oocyte meiosis_Homo sapiens_hsa041141.75603198
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68516269
26Amphetamine addiction_Homo sapiens_hsa050311.62587565
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.61911801
28Dorso-ventral axis formation_Homo sapiens_hsa043201.60303903
29Fanconi anemia pathway_Homo sapiens_hsa034601.56646613
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.54403942
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53837834
32Ribosome_Homo sapiens_hsa030101.52831575
33Fructose and mannose metabolism_Homo sapiens_hsa000511.50093042
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45148450
35Fat digestion and absorption_Homo sapiens_hsa049751.43092874
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.42856952
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42664047
38Carbon metabolism_Homo sapiens_hsa012001.42219101
39Ether lipid metabolism_Homo sapiens_hsa005651.31214422
40Cardiac muscle contraction_Homo sapiens_hsa042601.30986112
41Mineral absorption_Homo sapiens_hsa049781.27547684
42Fatty acid metabolism_Homo sapiens_hsa012121.27117560
43Fatty acid degradation_Homo sapiens_hsa000711.25347686
44Renin secretion_Homo sapiens_hsa049241.23207086
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21910540
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21908295
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20862223
48Huntingtons disease_Homo sapiens_hsa050161.19999146
49Tryptophan metabolism_Homo sapiens_hsa003801.18858379
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16922274
51Ovarian steroidogenesis_Homo sapiens_hsa049131.00555975
52Purine metabolism_Homo sapiens_hsa002300.98967905
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98821729
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98571539
55Antigen processing and presentation_Homo sapiens_hsa046120.98345540
56mRNA surveillance pathway_Homo sapiens_hsa030150.95909489
57Basal cell carcinoma_Homo sapiens_hsa052170.95868539
58ECM-receptor interaction_Homo sapiens_hsa045120.95736068
59Glutathione metabolism_Homo sapiens_hsa004800.95456355
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93095468
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92957421
62Biosynthesis of amino acids_Homo sapiens_hsa012300.92846455
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92291612
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90844711
65Insulin signaling pathway_Homo sapiens_hsa049100.89595378
66Collecting duct acid secretion_Homo sapiens_hsa049660.88751181
67Tight junction_Homo sapiens_hsa045300.88115070
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86277077
69Long-term potentiation_Homo sapiens_hsa047200.85234347
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84051721
71Adherens junction_Homo sapiens_hsa045200.82702036
72Steroid biosynthesis_Homo sapiens_hsa001000.80929118
73RNA transport_Homo sapiens_hsa030130.80715713
74Chemical carcinogenesis_Homo sapiens_hsa052040.78699918
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77720127
76Arachidonic acid metabolism_Homo sapiens_hsa005900.72421354
77Hedgehog signaling pathway_Homo sapiens_hsa043400.72284994
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70935262
79Parkinsons disease_Homo sapiens_hsa050120.70242137
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.69986360
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68294173
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67370539
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66960209
84Butanoate metabolism_Homo sapiens_hsa006500.66849829
85Estrogen signaling pathway_Homo sapiens_hsa049150.66689199
86Folate biosynthesis_Homo sapiens_hsa007900.66687881
87Insulin secretion_Homo sapiens_hsa049110.66643792
88Arginine and proline metabolism_Homo sapiens_hsa003300.66002228
89RNA polymerase_Homo sapiens_hsa030200.62889466
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.62109570
91Cell cycle_Homo sapiens_hsa041100.61720119
92ABC transporters_Homo sapiens_hsa020100.59411469
93Thyroid hormone synthesis_Homo sapiens_hsa049180.59201177
94Hippo signaling pathway_Homo sapiens_hsa043900.58238104
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57742012
96Bile secretion_Homo sapiens_hsa049760.57564570
97Systemic lupus erythematosus_Homo sapiens_hsa053220.57076533
98Circadian rhythm_Homo sapiens_hsa047100.56865045
99TGF-beta signaling pathway_Homo sapiens_hsa043500.56021754
100Morphine addiction_Homo sapiens_hsa050320.54916610
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54202465
102Regulation of autophagy_Homo sapiens_hsa041400.53469468
103Calcium signaling pathway_Homo sapiens_hsa040200.52260092
104Arginine biosynthesis_Homo sapiens_hsa002200.51976555
105One carbon pool by folate_Homo sapiens_hsa006700.51763520
106Vitamin digestion and absorption_Homo sapiens_hsa049770.51355374
107Melanogenesis_Homo sapiens_hsa049160.50184824
108Renin-angiotensin system_Homo sapiens_hsa046140.49901362
109VEGF signaling pathway_Homo sapiens_hsa043700.49137223
110Legionellosis_Homo sapiens_hsa051340.48132173
111Dilated cardiomyopathy_Homo sapiens_hsa054140.48000829
112AMPK signaling pathway_Homo sapiens_hsa041520.46254836
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43981402
114Gap junction_Homo sapiens_hsa045400.43937927
115Pancreatic secretion_Homo sapiens_hsa049720.42716234
116Lysine degradation_Homo sapiens_hsa003100.41175959
117Oxidative phosphorylation_Homo sapiens_hsa001900.40799041
118RNA degradation_Homo sapiens_hsa030180.40382855
119Proteasome_Homo sapiens_hsa030500.40125092
120Endocytosis_Homo sapiens_hsa041440.40030576
121Olfactory transduction_Homo sapiens_hsa047400.39859337
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.39363202
123Synaptic vesicle cycle_Homo sapiens_hsa047210.39146662
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38257860
125Metabolic pathways_Homo sapiens_hsa011000.37356533
126Salivary secretion_Homo sapiens_hsa049700.37022540
127Inositol phosphate metabolism_Homo sapiens_hsa005620.36692865
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35453691
129Protein digestion and absorption_Homo sapiens_hsa049740.33894431
130Sulfur metabolism_Homo sapiens_hsa009200.32368032
131Focal adhesion_Homo sapiens_hsa045100.31801094
132Thyroid cancer_Homo sapiens_hsa052160.30705056
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30176093
134Alzheimers disease_Homo sapiens_hsa050100.29958267
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29323814
136Gastric acid secretion_Homo sapiens_hsa049710.28273533
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27962566
138Alcoholism_Homo sapiens_hsa050340.27832874
139Pyrimidine metabolism_Homo sapiens_hsa002400.25660106
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25091091
141cAMP signaling pathway_Homo sapiens_hsa040240.24107932
142B cell receptor signaling pathway_Homo sapiens_hsa046620.23481268
143Taste transduction_Homo sapiens_hsa047420.21148592
144Circadian entrainment_Homo sapiens_hsa047130.20816861
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20526467
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20286576
147N-Glycan biosynthesis_Homo sapiens_hsa005100.20035256
148Wnt signaling pathway_Homo sapiens_hsa043100.16392697
149Cocaine addiction_Homo sapiens_hsa050300.15681149
150Viral carcinogenesis_Homo sapiens_hsa052030.10130814
151Salmonella infection_Homo sapiens_hsa051320.09078511
152Glutamatergic synapse_Homo sapiens_hsa047240.07259499
153Retinol metabolism_Homo sapiens_hsa008300.07099344

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