HRH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.47817802
2polyketide metabolic process (GO:0030638)7.47817802
3doxorubicin metabolic process (GO:0044598)7.47817802
4detection of other organism (GO:0098543)5.29656459
5response to peptidoglycan (GO:0032494)5.25135868
6detection of bacterium (GO:0016045)5.03692319
7negative regulation of cell killing (GO:0031342)5.01115594
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01115594
9regulation of B cell receptor signaling pathway (GO:0050855)4.84719886
10positive regulation of gamma-delta T cell activation (GO:0046645)4.79424152
11negative regulation of interleukin-12 production (GO:0032695)4.71725369
12aminoglycoside antibiotic metabolic process (GO:0030647)4.54176347
13leukocyte migration involved in inflammatory response (GO:0002523)4.30887603
14microglial cell activation (GO:0001774)4.28443789
15negative regulation of lymphocyte mediated immunity (GO:0002707)4.26727660
16immunoglobulin mediated immune response (GO:0016064)4.26478715
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.23902186
18leukocyte aggregation (GO:0070486)4.23389367
19negative regulation of mast cell activation (GO:0033004)4.14359183
20regulation of interferon-beta biosynthetic process (GO:0045357)4.08649375
21detection of biotic stimulus (GO:0009595)4.06429000
22interferon-gamma production (GO:0032609)3.98603165
23macrophage activation (GO:0042116)3.91071910
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.88834546
25mast cell activation (GO:0045576)3.81561184
26negative regulation of leukocyte mediated immunity (GO:0002704)3.81364697
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77049605
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.73820693
29positive regulation of mast cell activation (GO:0033005)3.71798826
30B cell receptor signaling pathway (GO:0050853)3.56906221
31production of molecular mediator involved in inflammatory response (GO:0002532)3.52453262
32cellular extravasation (GO:0045123)3.51121502
33cellular response to interleukin-15 (GO:0071350)3.48661018
34regulation of leukocyte degranulation (GO:0043300)3.46543008
35type I interferon signaling pathway (GO:0060337)3.46460328
36cellular response to type I interferon (GO:0071357)3.46460328
37response to type I interferon (GO:0034340)3.44000034
38modulation by symbiont of host immune response (GO:0052553)3.40253475
39positive regulation by symbiont of host defense response (GO:0052509)3.40253475
40modulation by symbiont of host defense response (GO:0052031)3.40253475
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40253475
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40253475
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.40253475
44response to interleukin-15 (GO:0070672)3.38652950
45response to muramyl dipeptide (GO:0032495)3.38581415
46myeloid leukocyte mediated immunity (GO:0002444)3.38519388
47mast cell degranulation (GO:0043303)3.36351143
48mast cell activation involved in immune response (GO:0002279)3.36351143
49regulation of tolerance induction (GO:0002643)3.35248855
50positive regulation of B cell differentiation (GO:0045579)3.35104136
51regulation of T cell tolerance induction (GO:0002664)3.34711448
52B cell mediated immunity (GO:0019724)3.34626622
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33847115
54regulation of T-helper 2 cell differentiation (GO:0045628)3.33547323
55positive regulation of mast cell degranulation (GO:0043306)3.30807326
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.30807326
57regulation of mast cell activation (GO:0033003)3.30791172
58antigen processing and presentation via MHC class Ib (GO:0002475)3.30423213
59regulation of B cell differentiation (GO:0045577)3.30299550
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27099396
61negative T cell selection (GO:0043383)3.26921637
62positive T cell selection (GO:0043368)3.25900983
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25537009
64interferon-gamma-mediated signaling pathway (GO:0060333)3.24143641
65negative thymic T cell selection (GO:0045060)3.23788474
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22789547
67positive thymic T cell selection (GO:0045059)3.21970652
68T cell migration (GO:0072678)3.21228111
69B cell homeostasis (GO:0001782)3.17934184
70negative regulation of cytokine production involved in immune response (GO:0002719)3.17257087
71regulation of gamma-delta T cell activation (GO:0046643)3.16803463
72regulation of regulated secretory pathway (GO:1903305)3.16178921
73negative regulation of erythrocyte differentiation (GO:0045647)3.13896388
74regulation of gamma-delta T cell differentiation (GO:0045586)3.13615984
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10770325
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10412008
77negative regulation of T-helper cell differentiation (GO:0045623)3.10412008
78detection of molecule of bacterial origin (GO:0032490)3.06232712
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03753537
80negative regulation of type 2 immune response (GO:0002829)3.03524043
81neutrophil chemotaxis (GO:0030593)3.03099494
82negative regulation of interleukin-6 production (GO:0032715)3.01455081
83regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00470625
84myeloid leukocyte activation (GO:0002274)2.99226858
85regulation of fever generation (GO:0031620)2.97484172
86positive regulation of heat generation (GO:0031652)2.96272483
87neutrophil migration (GO:1990266)2.95273320
88negative regulation of alpha-beta T cell activation (GO:0046636)2.94558790
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94421372
90response to host immune response (GO:0052572)2.94421372
91regulation of glutamate receptor signaling pathway (GO:1900449)2.93533661
92positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92809388
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92354092
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92354092
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.91989434
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91926242
97regulation of alpha-beta T cell proliferation (GO:0046640)2.91852010
98negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91492988
99germinal center formation (GO:0002467)2.90477968
100positive regulation of interferon-alpha production (GO:0032727)2.90183963
101tolerance induction (GO:0002507)2.89908508
102antigen receptor-mediated signaling pathway (GO:0050851)2.88287221
103negative regulation of phagocytosis (GO:0050765)2.85950705
104lymphocyte homeostasis (GO:0002260)2.85761895
105activated T cell proliferation (GO:0050798)2.84920456
106vocalization behavior (GO:0071625)2.83233827
107myeloid cell activation involved in immune response (GO:0002275)2.83120203
108response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82868797
109response to host (GO:0075136)2.82868797
110response to host defenses (GO:0052200)2.82868797
111neutrophil activation involved in immune response (GO:0002283)2.82093544
112regulation of mast cell degranulation (GO:0043304)2.80749945
113auditory receptor cell stereocilium organization (GO:0060088)2.79981066
114positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79158272
115positive regulation of granulocyte differentiation (GO:0030854)2.78984764
116respiratory burst (GO:0045730)2.78221471
117megakaryocyte development (GO:0035855)2.77580906
118T cell homeostasis (GO:0043029)2.74550325
119regulation of penile erection (GO:0060405)2.73979959
120neutrophil activation (GO:0042119)2.69792467
121T cell selection (GO:0045058)2.68697659
122antigen processing and presentation of endogenous antigen (GO:0019883)2.67566899
123negative regulation of granulocyte differentiation (GO:0030853)2.66315781
124positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65531850
125neutrophil mediated immunity (GO:0002446)2.65079350
126regulation of mast cell activation involved in immune response (GO:0033006)2.63924362
127leukocyte degranulation (GO:0043299)2.63918556
128neurotransmitter-gated ion channel clustering (GO:0072578)2.63322551
129negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62434729
130definitive hemopoiesis (GO:0060216)2.61916716
131B cell proliferation (GO:0042100)2.61644149
132positive regulation of cellular amide metabolic process (GO:0034250)2.57807098
133T cell receptor signaling pathway (GO:0050852)2.56770166
134negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.56560675
135negative regulation of T cell mediated immunity (GO:0002710)2.56124947
136necroptotic process (GO:0070266)2.56087544
137leukocyte homeostasis (GO:0001776)2.55547395
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.54558056
139regulation of germinal center formation (GO:0002634)2.54537736
140defense response to protozoan (GO:0042832)2.53596101
141lymphoid progenitor cell differentiation (GO:0002320)2.52981850
142natural killer cell activation (GO:0030101)2.51476166
143regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50388962
144response to protozoan (GO:0001562)2.49436471
145thymic T cell selection (GO:0045061)2.49011565
146detection of external biotic stimulus (GO:0098581)2.48569619
147macrophage activation involved in immune response (GO:0002281)2.47093608
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46770787
149granulocyte activation (GO:0036230)2.45011084

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38892544
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12079599
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.57468333
4EZH2_22144423_ChIP-Seq_EOC_Human3.38970634
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.37320585
6GBX2_23144817_ChIP-Seq_PC3_Human3.26343750
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16176640
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.06188310
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.01295426
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96336382
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74703656
12SCL_19346495_ChIP-Seq_HPC-7_Human2.59176175
13* RUNX_20019798_ChIP-Seq_JUKART_Human2.58160225
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.42315635
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.40530441
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36084330
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32950117
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22710532
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21030273
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19010951
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10000868
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07246530
23TAF15_26573619_Chip-Seq_HEK293_Human2.05801363
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01547481
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89821989
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89083092
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84686915
28MYB_26560356_Chip-Seq_TH2_Human1.76337347
29MAF_26560356_Chip-Seq_TH2_Human1.73253555
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70624007
31* KDM2B_26808549_Chip-Seq_DND41_Human1.67161268
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65678889
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62742271
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62662953
35* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61110938
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59316567
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59166233
38SPI1_23127762_ChIP-Seq_K562_Human1.58313725
39DROSHA_22980978_ChIP-Seq_HELA_Human1.57570841
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55066107
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53704823
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52905491
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.51531026
44* SPI1_23547873_ChIP-Seq_NB4_Human1.49283423
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46758148
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45789778
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45393105
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.44867578
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44020746
50PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42553155
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42360808
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41970478
53MYB_26560356_Chip-Seq_TH1_Human1.40028591
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38468773
55P300_19829295_ChIP-Seq_ESCs_Human1.34883453
56* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34647095
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32133260
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32116102
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30405869
60* REST_21632747_ChIP-Seq_MESCs_Mouse1.30190456
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29614709
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.29439054
63* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28221104
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27246376
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.25947353
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25256147
67VDR_24787735_ChIP-Seq_THP-1_Human1.24258460
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22612236
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22554534
70VDR_24763502_ChIP-Seq_THP-1_Human1.22234741
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21801919
72* GATA1_19941827_ChIP-Seq_MEL_Mouse1.21713070
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21535975
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20476853
75LXR_22292898_ChIP-Seq_THP-1_Human1.20309304
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20300595
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20091418
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18993039
79VDR_21846776_ChIP-Seq_THP-1_Human1.18653200
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17861882
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16328959
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15221425
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.14768752
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13832364
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.12306913
86MYC_22102868_ChIP-Seq_BL_Human1.11006619
87GATA3_26560356_Chip-Seq_TH2_Human1.10813102
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10373801
89RXR_22108803_ChIP-Seq_LS180_Human1.09871393
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.09727837
91GATA1_22025678_ChIP-Seq_K562_Human1.09264101
92GATA1_19941826_ChIP-Seq_K562_Human1.08489748
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07883253
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.07330335
95* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05838632
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05516819
97BCL6_27268052_Chip-Seq_Bcells_Human1.05493953
98MAF_26560356_Chip-Seq_TH1_Human1.05098276
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.04271770
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04139752
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.04058783
102UTX_26944678_Chip-Seq_JUKART_Human1.04024168
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02557919
104AR_25329375_ChIP-Seq_VCAP_Human1.01791188
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01767907
106* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01545981
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00832446
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00221390
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.00176839
110P53_22387025_ChIP-Seq_ESCs_Mouse0.98639444
111ER_23166858_ChIP-Seq_MCF-7_Human0.98561598
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.98306305
113* GATA3_27048872_Chip-Seq_THYMUS_Human0.98216732
114* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98162758
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97941789
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97621779
117BCOR_27268052_Chip-Seq_Bcells_Human0.96984253
118RARB_27405468_Chip-Seq_BRAIN_Mouse0.96739047
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95561023
120TCF4_23295773_ChIP-Seq_U87_Human0.94912935
121PU_27001747_Chip-Seq_BMDM_Mouse0.94646495
122* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94376866
123EGR1_19374776_ChIP-ChIP_THP-1_Human0.94097964
124AR_21572438_ChIP-Seq_LNCaP_Human0.93611095
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92943648
126SPI1_20517297_ChIP-Seq_HL60_Human0.92749042
127IGF1R_20145208_ChIP-Seq_DFB_Human0.92481652
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92369368
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92369368
130* TCF7_22412390_ChIP-Seq_EML_Mouse0.91831580
131* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91700127
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.91550093
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.89857442
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.88732994
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88329579
136GATA2_19941826_ChIP-Seq_K562_Human0.87776530
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87534287
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87242897
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85578129
140GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84692715
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83708260
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82847252
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80099187
144NCOR1_26117541_ChIP-Seq_K562_Human0.75552007
145SMRT_27268052_Chip-Seq_Bcells_Human0.72755353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.39833578
2MP0002822_catalepsy3.33507604
3MP0005671_abnormal_response_to3.22591500
4MP0001835_abnormal_antigen_presentation3.19117563
5MP0004859_abnormal_synaptic_plasticity2.54297633
6MP0001800_abnormal_humoral_immune2.49753431
7MP0009785_altered_susceptibility_to2.47712348
8MP0001790_abnormal_immune_system2.36915710
9MP0005387_immune_system_phenotype2.36915710
10MP0003880_abnormal_central_pattern2.35129568
11MP0002419_abnormal_innate_immunity2.29320929
12MP0003183_abnormal_peptide_metabolism2.25745745
13MP0005000_abnormal_immune_tolerance2.22427748
14MP0002420_abnormal_adaptive_immunity2.22425331
15MP0002723_abnormal_immune_serum2.21507425
16MP0001819_abnormal_immune_cell2.20163549
17MP0002452_abnormal_antigen_presenting2.19594582
18MP0003763_abnormal_thymus_physiology2.19577817
19MP0000685_abnormal_immune_system2.16648583
20MP0008004_abnormal_stomach_pH2.11426893
21MP0003191_abnormal_cellular_cholesterol2.05608345
22MP0003436_decreased_susceptibility_to2.05308645
23MP0005025_abnormal_response_to2.03847698
24MP0002148_abnormal_hypersensitivity_rea2.03625222
25MP0002398_abnormal_bone_marrow1.98845902
26MP0008260_abnormal_autophagy1.95569317
27MP0005464_abnormal_platelet_physiology1.91489227
28MP0003828_pulmonary_edema1.86112192
29MP0003303_peritoneal_inflammation1.85153491
30MP0002735_abnormal_chemical_nociception1.83367874
31MP0009046_muscle_twitch1.83338780
32MP0009745_abnormal_behavioral_response1.81851759
33MP0000716_abnormal_immune_system1.76906826
34MP0003635_abnormal_synaptic_transmissio1.73041813
35MP0003787_abnormal_imprinting1.72908380
36MP0002132_abnormal_respiratory_system1.72436687
37MP0005646_abnormal_pituitary_gland1.72369768
38MP0001188_hyperpigmentation1.72135501
39MP0003724_increased_susceptibility_to1.67980662
40MP0001873_stomach_inflammation1.63722305
41MP0001545_abnormal_hematopoietic_system1.62222561
42MP0005397_hematopoietic_system_phenotyp1.62222561
43MP0005451_abnormal_body_composition1.61241605
44MP0005174_abnormal_tail_pigmentation1.60484009
45* MP0002064_seizures1.59323502
46MP0004808_abnormal_hematopoietic_stem1.58882026
47MP0005645_abnormal_hypothalamus_physiol1.57184415
48MP0001968_abnormal_touch/_nociception1.53857446
49MP0006082_CNS_inflammation1.53362579
50MP0003879_abnormal_hair_cell1.52778660
51MP0000689_abnormal_spleen_morphology1.51668086
52MP0009278_abnormal_bone_marrow1.50405996
53MP0001986_abnormal_taste_sensitivity1.48316618
54MP0000569_abnormal_digit_pigmentation1.46969555
55MP0002572_abnormal_emotion/affect_behav1.44270539
56MP0002722_abnormal_immune_system1.43992095
57MP0002429_abnormal_blood_cell1.42535707
58MP0001501_abnormal_sleep_pattern1.40527949
59MP0005423_abnormal_somatic_nervous1.39089535
60MP0004381_abnormal_hair_follicle1.38077002
61MP0002405_respiratory_system_inflammati1.36738929
62MP0002736_abnormal_nociception_after1.36601112
63MP0005310_abnormal_salivary_gland1.36410564
64MP0001486_abnormal_startle_reflex1.35375970
65MP0000703_abnormal_thymus_morphology1.34135731
66MP0004510_myositis1.32592241
67MP0002063_abnormal_learning/memory/cond1.30228091
68MP0002998_abnormal_bone_remodeling1.27731819
69MP0003690_abnormal_glial_cell1.27645010
70MP0004883_abnormal_blood_vessel1.25017646
71MP0003866_abnormal_defecation1.23744416
72MP0001845_abnormal_inflammatory_respons1.22779842
73MP0005058_abnormal_lysosome_morphology1.22342024
74MP0002006_tumorigenesis1.21971378
75MP0008874_decreased_physiological_sensi1.15541521
76MP0002272_abnormal_nervous_system1.14835885
77MP0001853_heart_inflammation1.13027133
78MP0005075_abnormal_melanosome_morpholog1.11111428
79MP0010155_abnormal_intestine_physiology1.10766682
80MP0000465_gastrointestinal_hemorrhage1.08634503
81MP0002166_altered_tumor_susceptibility1.05833141
82MP0003300_gastrointestinal_ulcer1.04665449
83MP0000015_abnormal_ear_pigmentation1.03102816
84MP0005164_abnormal_response_to1.01964866
85MP0004924_abnormal_behavior1.00747413
86MP0005386_behavior/neurological_phenoty1.00747413
87MP0004147_increased_porphyrin_level1.00280328
88MP0001533_abnormal_skeleton_physiology0.99085548
89MP0009333_abnormal_splenocyte_physiolog0.98588368
90MP0003172_abnormal_lysosome_physiology0.98360211
91MP0001970_abnormal_pain_threshold0.95181925
92MP0000858_altered_metastatic_potential0.93278911
93MP0008569_lethality_at_weaning0.92324200
94MP0003448_altered_tumor_morphology0.91395610
95MP0000343_altered_response_to0.91266380
96MP0002277_abnormal_respiratory_mucosa0.90581790
97MP0000604_amyloidosis0.90093641
98MP0003075_altered_response_to0.89640870
99MP0006292_abnormal_olfactory_placode0.89355803
100MP0002067_abnormal_sensory_capabilities0.88428515
101MP0009763_increased_sensitivity_to0.88156402
102MP0009764_decreased_sensitivity_to0.87975346
103MP0003806_abnormal_nucleotide_metabolis0.86898672
104MP0005377_hearing/vestibular/ear_phenot0.86476109
105MP0003878_abnormal_ear_physiology0.86476109
106MP0002095_abnormal_skin_pigmentation0.85887400
107MP0005390_skeleton_phenotype0.85659765
108MP0009697_abnormal_copulation0.85383757
109MP0008469_abnormal_protein_level0.85147965
110MP0001851_eye_inflammation0.80484841
111MP0002933_joint_inflammation0.78833095
112MP0002733_abnormal_thermal_nociception0.76766325
113MP0004947_skin_inflammation0.75498879
114MP0001663_abnormal_digestive_system0.75443282
115MP0005166_decreased_susceptibility_to0.74418047
116MP0004130_abnormal_muscle_cell0.74074586
117MP0006276_abnormal_autonomic_nervous0.72329971
118MP0003045_fibrosis0.68492711
119MP0009765_abnormal_xenobiotic_induced0.67984458
120MP0003656_abnormal_erythrocyte_physiolo0.67455357
121MP0000490_abnormal_crypts_of0.62480060
122MP0003795_abnormal_bone_structure0.62457128
123MP0002332_abnormal_exercise_endurance0.62251609
124MP0002138_abnormal_hepatobiliary_system0.59736166
125MP0000920_abnormal_myelination0.59089157
126MP0004484_altered_response_of0.58879751
127MP0005319_abnormal_enzyme/_coenzyme0.54363824
128MP0000249_abnormal_blood_vessel0.54063364
129MP0003221_abnormal_cardiomyocyte_apopto0.53197006
130MP0005535_abnormal_body_temperature0.49765114
131MP0005388_respiratory_system_phenotype0.48406405
132MP0002133_abnormal_respiratory_system0.48406405
133MP0002693_abnormal_pancreas_physiology0.46461260
134MP0003329_amyloid_beta_deposits0.44341763
135MP0005376_homeostasis/metabolism_phenot0.41548333

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.11443456
2Recurrent abscess formation (HP:0002722)4.87665362
3Focal motor seizures (HP:0011153)4.45394587
4Recurrent bacterial skin infections (HP:0005406)4.16114411
5Gastrointestinal infarctions (HP:0005244)4.15424127
6Myositis (HP:0100614)3.80577795
7Eczematoid dermatitis (HP:0000976)3.77722757
8Recurrent fungal infections (HP:0002841)3.71460548
9Spontaneous hematomas (HP:0007420)3.66937233
10Mediastinal lymphadenopathy (HP:0100721)3.66569558
11Hypochromic microcytic anemia (HP:0004840)3.66534894
12Abnormal hair whorl (HP:0010721)3.58960419
13Increased IgE level (HP:0003212)3.55603497
14Recurrent viral infections (HP:0004429)3.44540359
15Chest pain (HP:0100749)3.29192643
16Prolonged bleeding time (HP:0003010)3.27996517
17Epileptic encephalopathy (HP:0200134)3.27985007
18IgM deficiency (HP:0002850)3.25709661
19Febrile seizures (HP:0002373)3.25329029
20Retrobulbar optic neuritis (HP:0100654)3.24036681
21Optic neuritis (HP:0100653)3.24036681
22Episodic fever (HP:0001954)3.22060662
23Stomatitis (HP:0010280)3.21963126
24Panhypogammaglobulinemia (HP:0003139)3.20571093
25Meningitis (HP:0001287)3.19234912
26Hypochromic anemia (HP:0001931)3.16816950
27Hyperventilation (HP:0002883)3.16055577
28Chronic obstructive pulmonary disease (HP:0006510)3.13013835
29Obstructive lung disease (HP:0006536)3.13013835
30Amyloidosis (HP:0011034)3.08711778
31Chronic sinusitis (HP:0011109)3.07086340
32Cheilitis (HP:0100825)3.03024440
33Chronic mucocutaneous candidiasis (HP:0002728)3.01370686
34Recurrent cutaneous fungal infections (HP:0011370)3.01370686
35Elevated erythrocyte sedimentation rate (HP:0003565)2.96041758
36Agammaglobulinemia (HP:0004432)2.95602067
37Orchitis (HP:0100796)2.86396014
38Pulmonary embolism (HP:0002204)2.84924094
39Anorexia (HP:0002039)2.84702172
40Recurrent skin infections (HP:0001581)2.82094511
41Thyroiditis (HP:0100646)2.80635572
42Recurrent gram-negative bacterial infections (HP:0005420)2.78744579
43T lymphocytopenia (HP:0005403)2.69392897
44Peritonitis (HP:0002586)2.68953526
45B lymphocytopenia (HP:0010976)2.66703642
46Abnormality of B cell number (HP:0010975)2.66703642
47Cellulitis (HP:0100658)2.66403572
48Increased IgM level (HP:0003496)2.62659677
49Atonic seizures (HP:0010819)2.60460835
50Pustule (HP:0200039)2.60206590
51Gangrene (HP:0100758)2.58832110
52Abnormality of T cell number (HP:0011839)2.55230775
53Vasculitis (HP:0002633)2.54820604
54Petechiae (HP:0000967)2.54242324
55Abnormality of macrophages (HP:0004311)2.52891485
56Abnormality of the pleura (HP:0002103)2.44481266
57Abnormality of eosinophils (HP:0001879)2.44005953
58Severe combined immunodeficiency (HP:0004430)2.37714679
59Protruding tongue (HP:0010808)2.37239047
60Abnormality of binocular vision (HP:0011514)2.36599765
61Diplopia (HP:0000651)2.36599765
62Microcytic anemia (HP:0001935)2.36578854
63Recurrent bronchitis (HP:0002837)2.33814977
64Vertigo (HP:0002321)2.32945270
65Abnormality of the endocardium (HP:0004306)2.32765477
66Lymphopenia (HP:0001888)2.32565939
67Encephalitis (HP:0002383)2.31946911
68IgG deficiency (HP:0004315)2.31744651
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.31087120
70Eosinophilia (HP:0001880)2.30591519
71Pulmonary infiltrates (HP:0002113)2.30056506
72Parakeratosis (HP:0001036)2.28594301
73Sepsis (HP:0100806)2.28444440
74Abnormality of the prostate (HP:0008775)2.28062720
75Urticaria (HP:0001025)2.27953150
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27501671
77Hypergammaglobulinemia (HP:0010702)2.25908384
78Purpura (HP:0000979)2.24647565
79Increased cerebral lipofuscin (HP:0011813)2.23618406
80Gingival bleeding (HP:0000225)2.22677618
81Loss of speech (HP:0002371)2.22438885
82Keratitis (HP:0000491)2.19744990
83Chronic diarrhea (HP:0002028)2.18345513
84Epistaxis (HP:0000421)2.17284503
85Focal seizures (HP:0007359)2.16977224
86Abnormality of the peritoneum (HP:0002585)2.16812515
87Glomerulopathy (HP:0100820)2.16192936
88Inflammation of the large intestine (HP:0002037)2.15806327
89Leukocytosis (HP:0001974)2.14412662
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.12500693
91Abnormality of the fingertips (HP:0001211)2.12486578
92Abnormality of glycolipid metabolism (HP:0010969)2.10460328
93Abnormality of liposaccharide metabolism (HP:0010968)2.10460328
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.10460328
95Abnormality of dental color (HP:0011073)2.10212220
96Hepatosplenomegaly (HP:0001433)2.08589977
97Abnormality of T cell physiology (HP:0011840)2.07779376
98Gingivitis (HP:0000230)2.07629129
99Gastrointestinal stroma tumor (HP:0100723)2.07112012
100Acne (HP:0001061)2.06923343
101Acute lymphatic leukemia (HP:0006721)2.06656538
102Bilateral sensorineural hearing impairment (HP:0008619)2.05730164
103Increased serum ferritin (HP:0003281)2.05646533
104Skin ulcer (HP:0200042)2.05452506
105Slow saccadic eye movements (HP:0000514)2.05395705
106Broad-based gait (HP:0002136)2.05263442
107Abnormality of T cells (HP:0002843)2.04862198
108Granulocytopenia (HP:0001913)2.04774719
109Gastrointestinal inflammation (HP:0004386)2.04763277
110Keratoconjunctivitis sicca (HP:0001097)2.02834829
111Premature loss of primary teeth (HP:0006323)2.02562529
112Polyneuropathy (HP:0001271)2.02312183
113Hemoptysis (HP:0002105)2.02036084
114Recurrent pneumonia (HP:0006532)2.01392432
115Abnormality of the pericardium (HP:0001697)2.00548758
116Impaired platelet aggregation (HP:0003540)2.00240034
117Abnormal platelet function (HP:0011869)2.00240034
118Arterial thrombosis (HP:0004420)1.95445846
119Volvulus (HP:0002580)1.94615684
120Abnormality of iron homeostasis (HP:0011031)1.94228346
121Colitis (HP:0002583)1.93877236
122Absence seizures (HP:0002121)1.91415465
123Combined immunodeficiency (HP:0005387)1.89893710
124Generalized hypopigmentation of hair (HP:0011358)1.89463808
125Fair hair (HP:0002286)1.88934997
126Dialeptic seizures (HP:0011146)1.88759156
127Abnormal platelet volume (HP:0011876)1.86940683
128Osteomyelitis (HP:0002754)1.86203550
129Skin rash (HP:0000988)1.86150993
130Acute myeloid leukemia (HP:0004808)1.86093902
131Acute hepatic failure (HP:0006554)1.85631269
132Spinal canal stenosis (HP:0003416)1.85264614
133Inappropriate behavior (HP:0000719)1.84593150
134Systemic lupus erythematosus (HP:0002725)1.84501048
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.84260119
136Absent/shortened dynein arms (HP:0200106)1.84059630
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.84059630
138Gaze-evoked nystagmus (HP:0000640)1.83858521
139Poor eye contact (HP:0000817)1.83658420
140Thrombophlebitis (HP:0004418)1.82603725
141Unilateral renal agenesis (HP:0000122)1.82493352
142Widely spaced teeth (HP:0000687)1.79595101
143Keratoconjunctivitis (HP:0001096)1.78900049
144Erythema (HP:0010783)1.78547186
145Papilledema (HP:0001085)1.77537159
146Disinhibition (HP:0000734)1.76857845
147Hip dysplasia (HP:0001385)1.76573238
148Hypermelanotic macule (HP:0001034)1.75748321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.12224269
2SIK34.01873174
3MAP4K13.86627780
4CASK3.15380126
5KIT3.00170565
6SIK22.93452610
7RIPK42.70058090
8ERN12.69942114
9MAP3K122.69733466
10PRPF4B2.29376005
11FES2.24405482
12TNIK2.03478926
13TAOK12.01332191
14EPHB11.91909376
15NTRK31.89833324
16IRAK41.86761110
17MAP3K31.82716680
18MAP3K141.81021709
19MAP3K131.80404156
20MAP3K111.75044068
21FGR1.71626362
22ADRBK21.68830087
23TEC1.67825499
24CSF1R1.67633850
25SYK1.58323920
26JAK31.56461780
27CCNB11.54601418
28MARK31.52083111
29IKBKE1.48464438
30ZAP701.48448351
31MAP2K71.45967688
32JAK11.42272322
33DAPK11.38227970
34SGK21.37307378
35CDK81.36922051
36ITK1.36807982
37TYK21.35074934
38MAP3K11.34041994
39BTK1.32102982
40TNK21.31898580
41SGK31.28848944
42MATK1.19302620
43KSR21.18176291
44BLK1.18118682
45HCK1.18102321
46LCK1.14137574
47GRK61.06260038
48LYN1.00492232
49TSSK60.99005728
50CDK190.97635317
51CLK10.96651864
52TBK10.95518645
53IRAK10.95409548
54YES10.94757438
55MAP3K70.94171563
56GRK70.93666967
57EPHA40.90770612
58CSK0.90190373
59TAOK30.86784523
60BRD40.85504801
61PRKD20.85242407
62MUSK0.84421881
63IKBKB0.83805792
64IRAK20.83061771
65MAP3K60.81809029
66STK100.81777550
67MAP2K30.81606642
68PLK20.81154923
69PDPK10.80087188
70MARK20.79554757
71TGFBR20.71667351
72PRKCH0.70507120
73FLT30.69755455
74PRKCQ0.68015071
75PIK3CG0.67944756
76MAP3K40.67607576
77MAP3K50.67563517
78STK110.66962278
79PTK60.65044931
80DAPK20.64882293
81CAMK10.64021565
82MAP3K90.63260309
83PTK2B0.60629010
84SGK4940.58848107
85SGK2230.58848107
86VRK10.58524021
87MAPK70.58517353
88IRAK30.57672928
89STK240.57281275
90SMG10.57001699
91NTRK20.56910133
92CDC42BPA0.53569743
93CAMK40.53477519
94TRIB30.53384659
95TESK20.53085519
96MAP2K60.51829393
97BMPR20.51810467
98LRRK20.50708467
99CAMKK10.50030927
100PDK10.49868289
101SGK10.49565305
102PIM10.48265711
103MAP3K20.47890261
104MAP2K40.47826528
105MAPK120.47530822
106FGFR30.45335507
107TAOK20.44839210
108EPHA30.44197445
109RPS6KL10.43472538
110RPS6KC10.43472538
111EEF2K0.42688073
112MAPK40.42468385
113STK380.41746539
114RAF10.41048833
115MAP3K100.40887140
116RET0.40351929
117CHUK0.40198877
118FYN0.39357298
119HIPK20.38736729
120MOS0.38016874
121PAK40.37858397
122CAMKK20.37138291
123NLK0.36837384
124SIK10.36563185
125JAK20.36389117
126RPS6KA60.36286769
127AKT30.36277024
128ALK0.35914283
129DYRK1B0.35018370
130CDK30.33958039
131CDK50.33913034
132MAPKAPK20.33046576
133MAPK130.30702738
134CDK40.30539722
135PRKCZ0.29827108
136PRKCD0.29418572
137PRKD10.28660378
138MAPK110.26170208
139MINK10.25126222

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.81777917
2Nicotine addiction_Homo sapiens_hsa050332.25256477
3Leishmaniasis_Homo sapiens_hsa051402.18605254
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12015380
5Hematopoietic cell lineage_Homo sapiens_hsa046402.02638797
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96832503
7B cell receptor signaling pathway_Homo sapiens_hsa046621.95969438
8Osteoclast differentiation_Homo sapiens_hsa043801.85689420
9Morphine addiction_Homo sapiens_hsa050321.84704392
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.78198087
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.77148022
12T cell receptor signaling pathway_Homo sapiens_hsa046601.73203328
13Measles_Homo sapiens_hsa051621.72979401
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68599791
15Synaptic vesicle cycle_Homo sapiens_hsa047211.66897832
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66249352
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64723587
18Olfactory transduction_Homo sapiens_hsa047401.59422108
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52441048
20Viral myocarditis_Homo sapiens_hsa054161.50679179
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43843211
22Chemokine signaling pathway_Homo sapiens_hsa040621.43786947
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42918169
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42906004
25Allograft rejection_Homo sapiens_hsa053301.38307213
26Tuberculosis_Homo sapiens_hsa051521.38301955
27Collecting duct acid secretion_Homo sapiens_hsa049661.34672534
28Rheumatoid arthritis_Homo sapiens_hsa053231.30830625
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28146259
30Type I diabetes mellitus_Homo sapiens_hsa049401.24264285
31GABAergic synapse_Homo sapiens_hsa047271.21844297
32Asthma_Homo sapiens_hsa053101.21046773
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18227723
34Circadian entrainment_Homo sapiens_hsa047131.16043165
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15013395
36* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13352594
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.11705167
38Graft-versus-host disease_Homo sapiens_hsa053321.08795572
39Glutamatergic synapse_Homo sapiens_hsa047241.08386787
40African trypanosomiasis_Homo sapiens_hsa051431.07597029
41Long-term potentiation_Homo sapiens_hsa047201.07061298
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06771115
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06000404
44Platelet activation_Homo sapiens_hsa046111.05700130
45Toxoplasmosis_Homo sapiens_hsa051451.05343809
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04823907
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02081950
48Influenza A_Homo sapiens_hsa051641.01639038
49Acute myeloid leukemia_Homo sapiens_hsa052211.01486281
50TNF signaling pathway_Homo sapiens_hsa046680.99386338
51Hepatitis B_Homo sapiens_hsa051610.98804306
52Pertussis_Homo sapiens_hsa051330.98415121
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98246783
54Salivary secretion_Homo sapiens_hsa049700.97669189
55Serotonergic synapse_Homo sapiens_hsa047260.94651560
56VEGF signaling pathway_Homo sapiens_hsa043700.94331910
57Herpes simplex infection_Homo sapiens_hsa051680.93358538
58Staphylococcus aureus infection_Homo sapiens_hsa051500.92829357
59* Calcium signaling pathway_Homo sapiens_hsa040200.92176435
60Shigellosis_Homo sapiens_hsa051310.89998035
61Cholinergic synapse_Homo sapiens_hsa047250.87477707
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86898987
63Taste transduction_Homo sapiens_hsa047420.85500898
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84271046
65Long-term depression_Homo sapiens_hsa047300.84030172
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82895223
67Autoimmune thyroid disease_Homo sapiens_hsa053200.81919126
68MAPK signaling pathway_Homo sapiens_hsa040100.81641357
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.81211213
70Antigen processing and presentation_Homo sapiens_hsa046120.79888127
71Oxytocin signaling pathway_Homo sapiens_hsa049210.79167317
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78465460
73Type II diabetes mellitus_Homo sapiens_hsa049300.78068888
74Salmonella infection_Homo sapiens_hsa051320.77813839
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77754832
76Renin secretion_Homo sapiens_hsa049240.77720502
77Lysosome_Homo sapiens_hsa041420.77636171
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77440560
79Dopaminergic synapse_Homo sapiens_hsa047280.76393287
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.74343256
81Amphetamine addiction_Homo sapiens_hsa050310.73898563
82Phagosome_Homo sapiens_hsa041450.73505867
83Endocytosis_Homo sapiens_hsa041440.73328265
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.73310124
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73055323
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.72521172
87Renal cell carcinoma_Homo sapiens_hsa052110.71149052
88Malaria_Homo sapiens_hsa051440.70954846
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70261480
90Legionellosis_Homo sapiens_hsa051340.70096919
91cAMP signaling pathway_Homo sapiens_hsa040240.69717937
92GnRH signaling pathway_Homo sapiens_hsa049120.68615391
93Pancreatic cancer_Homo sapiens_hsa052120.68603748
94* Gastric acid secretion_Homo sapiens_hsa049710.68423710
95Rap1 signaling pathway_Homo sapiens_hsa040150.66138840
96Amoebiasis_Homo sapiens_hsa051460.65024976
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64951496
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.64102912
99Non-small cell lung cancer_Homo sapiens_hsa052230.61804808
100Inositol phosphate metabolism_Homo sapiens_hsa005620.60515306
101Epstein-Barr virus infection_Homo sapiens_hsa051690.60412834
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59567058
103Hepatitis C_Homo sapiens_hsa051600.58707378
104Apoptosis_Homo sapiens_hsa042100.57537732
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57184633
106Other glycan degradation_Homo sapiens_hsa005110.56873407
107FoxO signaling pathway_Homo sapiens_hsa040680.56854710
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56186617
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55773420
110Choline metabolism in cancer_Homo sapiens_hsa052310.55733691
111Glioma_Homo sapiens_hsa052140.55725846
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55316966
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54208083
114Chronic myeloid leukemia_Homo sapiens_hsa052200.54088690
115Dorso-ventral axis formation_Homo sapiens_hsa043200.54023357
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52447676
117Regulation of autophagy_Homo sapiens_hsa041400.51743402
118Prolactin signaling pathway_Homo sapiens_hsa049170.50635663
119ErbB signaling pathway_Homo sapiens_hsa040120.50375039
120Insulin secretion_Homo sapiens_hsa049110.50033621
121Notch signaling pathway_Homo sapiens_hsa043300.49125250
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.49038404
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48653711
124mTOR signaling pathway_Homo sapiens_hsa041500.48234098
125HTLV-I infection_Homo sapiens_hsa051660.47370943
126Endometrial cancer_Homo sapiens_hsa052130.47362803
127Insulin resistance_Homo sapiens_hsa049310.47296731
128Viral carcinogenesis_Homo sapiens_hsa052030.44773298
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42853746
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.42240115
131Estrogen signaling pathway_Homo sapiens_hsa049150.36906843
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36001396

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