HRH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adult feeding behavior (GO:0008343)9.22208051
2regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033398.94712884
3labyrinthine layer development (GO:0060711)7.62605483
4negative regulation of metanephros development (GO:0072217)6.57350108
5positive regulation of mast cell activation involved in immune response (GO:0033008)6.55235270
6positive regulation of mast cell degranulation (GO:0043306)6.55235270
7angiotensin maturation (GO:0002003)6.10260818
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.05047728
9negative regulation of cell killing (GO:0031342)6.05047728
10positive regulation of mast cell activation (GO:0033005)6.04865321
11regulation of feeding behavior (GO:0060259)6.01470830
12melanin biosynthetic process (GO:0042438)5.88735854
13drinking behavior (GO:0042756)5.75105646
14melanin metabolic process (GO:0006582)5.74567148
15positive regulation of myeloid leukocyte mediated immunity (GO:0002888)5.38380934
16behavioral response to nicotine (GO:0035095)5.31746440
17regulation of hypersensitivity (GO:0002883)5.27635524
18response to pheromone (GO:0019236)5.13594620
19negative regulation of T cell receptor signaling pathway (GO:0050860)5.04359253
20neuromuscular process controlling posture (GO:0050884)5.04074479
21negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.94917306
22respiratory system process (GO:0003016)4.78430225
23positive regulation of leukocyte degranulation (GO:0043302)4.66016870
24secondary metabolite biosynthetic process (GO:0044550)4.63160197
25tyrosine phosphorylation of STAT protein (GO:0007260)4.62118232
26negative thymic T cell selection (GO:0045060)4.39796813
27negative T cell selection (GO:0043383)4.34202237
28indole-containing compound catabolic process (GO:0042436)4.07088742
29indolalkylamine catabolic process (GO:0046218)4.07088742
30tryptophan catabolic process (GO:0006569)4.07088742
31regulation of T cell receptor signaling pathway (GO:0050856)4.04769993
32positive regulation of regulated secretory pathway (GO:1903307)3.99807836
33L-fucose catabolic process (GO:0042355)3.99728233
34fucose catabolic process (GO:0019317)3.99728233
35L-fucose metabolic process (GO:0042354)3.99728233
36positive regulation of gamma-delta T cell activation (GO:0046645)3.98943403
37indolalkylamine metabolic process (GO:0006586)3.97631326
38positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.86312321
39DNA deamination (GO:0045006)3.85913134
40kynurenine metabolic process (GO:0070189)3.85844882
41piRNA metabolic process (GO:0034587)3.81807712
42tolerance induction (GO:0002507)3.79083569
43SMAD protein signal transduction (GO:0060395)3.72778928
44negative regulation of tissue remodeling (GO:0034104)3.72039541
45thymic T cell selection (GO:0045061)3.63351463
46photoperiodism (GO:0009648)3.62452850
47tryptophan metabolic process (GO:0006568)3.62018191
48regulation of mast cell degranulation (GO:0043304)3.60842340
49regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.58785848
50neuronal action potential propagation (GO:0019227)3.56945202
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54325846
52activation of protein kinase A activity (GO:0034199)3.53688043
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.52416513
54response to interleukin-6 (GO:0070741)3.52303299
55regulation of isotype switching to IgG isotypes (GO:0048302)3.49477254
56eating behavior (GO:0042755)3.49298550
57leukocyte aggregation (GO:0070486)3.46024614
58T cell migration (GO:0072678)3.44996084
59negative regulation of kidney development (GO:0090185)3.44830783
60phospholipid scrambling (GO:0017121)3.42228025
61response to interleukin-15 (GO:0070672)3.42143460
62alanine transport (GO:0032328)3.39899732
63positive regulation of megakaryocyte differentiation (GO:0045654)3.38266597
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36366403
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.35829098
66melanocyte differentiation (GO:0030318)3.34787587
67negative regulation of mast cell activation (GO:0033004)3.34111007
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33649541
69regulation of mast cell activation involved in immune response (GO:0033006)3.33460605
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31765934
71detection of light stimulus involved in visual perception (GO:0050908)3.29983342
72detection of light stimulus involved in sensory perception (GO:0050962)3.29983342
73T cell selection (GO:0045058)3.24821985
74L-serine transport (GO:0015825)3.23471121
75neural tube formation (GO:0001841)3.22129279
76regulation of memory T cell differentiation (GO:0043380)3.20256082
77cellular ketone body metabolic process (GO:0046950)3.17781262
78regulation of extracellular matrix disassembly (GO:0010715)3.17145977
79negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15103699
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14211245
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.14211245
82positive regulation of prostaglandin secretion (GO:0032308)3.12366670
83positive regulation of fatty acid transport (GO:2000193)3.11566557
84regulation of leukocyte degranulation (GO:0043300)3.09196421
85regulation of norepinephrine secretion (GO:0014061)3.08454513
86regulation of regulated secretory pathway (GO:1903305)3.05681656
87preassembly of GPI anchor in ER membrane (GO:0016254)3.04372399
88protein K11-linked deubiquitination (GO:0035871)3.03641740
89serine transport (GO:0032329)3.03035632
90platelet dense granule organization (GO:0060155)3.02643973
91positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.99090643
92positive thymic T cell selection (GO:0045059)2.98829467
93negative regulation of protein autophosphorylation (GO:0031953)2.97890455
94negative regulation of telomere maintenance (GO:0032205)2.97839671
95cellular biogenic amine catabolic process (GO:0042402)2.97344280
96amine catabolic process (GO:0009310)2.97344280
97regulation of activation of Janus kinase activity (GO:0010533)2.97092613
98epithelial cilium movement (GO:0003351)2.96914688
99mast cell activation (GO:0045576)2.95349945
100DNA methylation involved in gamete generation (GO:0043046)2.94385563
101neuronal action potential (GO:0019228)2.94020122
102response to interleukin-4 (GO:0070670)2.93990586
103indole-containing compound metabolic process (GO:0042430)2.93640036
104regulation of gamma-delta T cell differentiation (GO:0045586)2.90855277
105regulation of tight junction assembly (GO:2000810)2.90109318
106cilium or flagellum-dependent cell motility (GO:0001539)2.89759853
107negative regulation of type 2 immune response (GO:0002829)2.89387618
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88359622
109regulation of T cell tolerance induction (GO:0002664)2.87195419
110T cell receptor signaling pathway (GO:0050852)2.86915691
111regulation of B cell receptor signaling pathway (GO:0050855)2.84692393
112ketone body metabolic process (GO:1902224)2.84346148
113positive regulation of interleukin-2 production (GO:0032743)2.84301440
114sodium ion export (GO:0071436)2.83675763
115regulation of mast cell activation (GO:0033003)2.83672381
116pigment cell differentiation (GO:0050931)2.83087429
117cell communication by electrical coupling (GO:0010644)2.81713279
118cellular sodium ion homeostasis (GO:0006883)2.81344818
119negative regulation of cAMP-mediated signaling (GO:0043951)2.81182470
120phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80672003
121positive regulation of T cell cytokine production (GO:0002726)2.80467476
122mast cell degranulation (GO:0043303)2.77446432
123mast cell activation involved in immune response (GO:0002279)2.77446432
124mesenchymal to epithelial transition (GO:0060231)2.73794055
125cellular potassium ion homeostasis (GO:0030007)2.72875450
126nonmotile primary cilium assembly (GO:0035058)2.72649053
127sulfation (GO:0051923)2.72327868
128axoneme assembly (GO:0035082)2.70289993
129negative regulation of interleukin-1 production (GO:0032692)2.70254616
130photoreceptor cell maintenance (GO:0045494)2.69605672
131positive regulation of icosanoid secretion (GO:0032305)2.69507564
132positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68023536
133reciprocal meiotic recombination (GO:0007131)2.67823144
134reciprocal DNA recombination (GO:0035825)2.67823144
135positive regulation of B cell differentiation (GO:0045579)2.67493174
136detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.66120847
137dopamine transport (GO:0015872)2.65340774
138antigen processing and presentation of endogenous antigen (GO:0019883)2.65271481
139interferon-gamma production (GO:0032609)2.65176244
140kidney morphogenesis (GO:0060993)2.64739649
141negative regulation of amino acid transport (GO:0051956)2.64687210
142regulation of beta-amyloid formation (GO:1902003)2.64576353
143activated T cell proliferation (GO:0050798)2.64492065
144positive T cell selection (GO:0043368)2.63835842
145cellular response to interleukin-15 (GO:0071350)2.63278128
146male meiosis I (GO:0007141)2.62887463
147negative regulation of catecholamine secretion (GO:0033604)2.62885719
148behavioral response to ethanol (GO:0048149)2.62281642
149mannosylation (GO:0097502)2.60347020
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60346247
151cellular response to ATP (GO:0071318)2.57772076
152water-soluble vitamin biosynthetic process (GO:0042364)2.56280258
153positive regulation of defense response to virus by host (GO:0002230)2.56115732
154multicellular organism reproduction (GO:0032504)2.55476121
155rhodopsin mediated signaling pathway (GO:0016056)2.55278616
156protein localization to cilium (GO:0061512)2.54020062
157protein complex biogenesis (GO:0070271)2.53972884
158regulation of cilium movement (GO:0003352)2.52389983
159cytochrome complex assembly (GO:0017004)2.51651133
160cAMP catabolic process (GO:0006198)2.50807149
161regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49954086
162primary amino compound metabolic process (GO:1901160)2.49913839
163G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49844921
164synaptic transmission, cholinergic (GO:0007271)2.49685206
165negative regulation of interleukin-1 beta production (GO:0032691)2.48830629
166respiratory chain complex IV assembly (GO:0008535)2.48386603
167cilium morphogenesis (GO:0060271)2.48297126
168regulation of action potential (GO:0098900)2.47736163
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45998215
170cornea development in camera-type eye (GO:0061303)2.45981344
171regulation of hexokinase activity (GO:1903299)2.45299525
172regulation of glucokinase activity (GO:0033131)2.45299525
173gamma-aminobutyric acid transport (GO:0015812)2.45291079
174opioid receptor signaling pathway (GO:0038003)2.45147149
175regulation of rhodopsin mediated signaling pathway (GO:0022400)2.45045292
176nephron tubule morphogenesis (GO:0072078)2.44173123
177nephron epithelium morphogenesis (GO:0072088)2.44173123
178RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39954379
179cilium movement (GO:0003341)2.39002554
180male meiosis (GO:0007140)2.38280855
181protein-cofactor linkage (GO:0018065)2.37981093
182cytidine metabolic process (GO:0046087)2.37199977
183cytidine catabolic process (GO:0006216)2.37199977
184cytidine deamination (GO:0009972)2.37199977
185DNA demethylation (GO:0080111)2.36878728
186negative regulation of reactive oxygen species metabolic process (GO:2000378)2.36461325
187tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36390979
188RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.36390979
189adaptation of signaling pathway (GO:0023058)2.35903687
190amino acid salvage (GO:0043102)2.35626977
191L-methionine salvage (GO:0071267)2.35626977
192L-methionine biosynthetic process (GO:0071265)2.35626977
193regulation of prostaglandin secretion (GO:0032306)2.35087645
194retinal cone cell development (GO:0046549)2.35012207
195signal peptide processing (GO:0006465)2.34339795
196protein polyglutamylation (GO:0018095)2.32635475
197mitochondrial respiratory chain complex assembly (GO:0033108)2.32593525
198NAD biosynthetic process (GO:0009435)2.32343388
199response to parathyroid hormone (GO:0071107)11.4616195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.48781866
2EZH2_22144423_ChIP-Seq_EOC_Human5.14673490
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.77675373
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.41196830
5ZNF274_21170338_ChIP-Seq_K562_Hela3.92061208
6RUNX_20019798_ChIP-Seq_JUKART_Human3.20432239
7VDR_22108803_ChIP-Seq_LS180_Human2.90436131
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71594486
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.71253354
10GBX2_23144817_ChIP-Seq_PC3_Human2.65758760
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64870707
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.56873626
13AR_21572438_ChIP-Seq_LNCaP_Human2.56453733
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.54418737
15VDR_21846776_ChIP-Seq_THP-1_Human2.47591511
16MAF_26560356_Chip-Seq_TH1_Human2.46554523
17IGF1R_20145208_ChIP-Seq_DFB_Human2.39288953
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37209269
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27797811
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26706070
21* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19210627
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13522653
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04446927
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03785775
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02632340
26ER_23166858_ChIP-Seq_MCF-7_Human2.00750079
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00103487
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97373242
29KDM2B_26808549_Chip-Seq_DND41_Human1.95327950
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93093727
31VDR_24763502_ChIP-Seq_THP-1_Human1.92882688
32UTX_26944678_Chip-Seq_JUKART_Human1.91612832
33DROSHA_22980978_ChIP-Seq_HELA_Human1.91245517
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.90336936
35MYB_26560356_Chip-Seq_TH2_Human1.86138189
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84042747
37TCF7_22412390_ChIP-Seq_EML_Mouse1.83837696
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81856234
39* P300_19829295_ChIP-Seq_ESCs_Human1.77686476
40EWS_26573619_Chip-Seq_HEK293_Human1.75675398
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.75642217
42SPI1_23127762_ChIP-Seq_K562_Human1.75030824
43* GATA1_19941827_ChIP-Seq_MEL_Mouse1.74611013
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.73571203
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72475412
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71664856
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71580790
48SCL_19346495_ChIP-Seq_HPC-7_Human1.71240276
49LXR_22292898_ChIP-Seq_THP-1_Human1.69098130
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68887897
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67987353
52FUS_26573619_Chip-Seq_HEK293_Human1.66840960
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64782323
54ZNF263_19887448_ChIP-Seq_K562_Human1.64331178
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61610429
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59991405
57BCAT_22108803_ChIP-Seq_LS180_Human1.58482953
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.58355268
59TAF15_26573619_Chip-Seq_HEK293_Human1.58316603
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.57387843
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57120334
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56821550
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54513304
64TP53_22573176_ChIP-Seq_HFKS_Human1.53787972
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53725821
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53642262
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51124953
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.50439416
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50346839
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50070868
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.49328150
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49252050
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.49232247
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49232247
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.49007119
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46770154
77IRF1_19129219_ChIP-ChIP_H3396_Human1.46395812
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.46011683
79MAF_26560356_Chip-Seq_TH2_Human1.45969273
80* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45749612
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44659000
82STAT3_23295773_ChIP-Seq_U87_Human1.44420862
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43832655
84* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42894360
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42526305
86EGR1_19032775_ChIP-ChIP_M12_Human1.40758494
87* TCF4_23295773_ChIP-Seq_U87_Human1.40677163
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39597354
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37957467
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37728623
91CBP_20019798_ChIP-Seq_JUKART_Human1.36481514
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36481514
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36474125
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.35942686
95ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35496702
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.34670442
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33229852
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32111387
99AR_25329375_ChIP-Seq_VCAP_Human1.31954547
100SOX2_19829295_ChIP-Seq_ESCs_Human1.31828638
101NANOG_19829295_ChIP-Seq_ESCs_Human1.31828638
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.31767399
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30615710
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30373970
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29601922
106SMAD4_21799915_ChIP-Seq_A2780_Human1.29133476
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29081161
108GATA3_27048872_Chip-Seq_THYMUS_Human1.28815742
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.28005790
110TCF4_22108803_ChIP-Seq_LS180_Human1.27005185
111MYB_26560356_Chip-Seq_TH1_Human1.26597403
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26525446
113* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25990034
114* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25990034
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.25621257
116* IRF8_27001747_Chip-Seq_BMDM_Mouse1.25102753
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24868768
118MYC_18940864_ChIP-ChIP_HL60_Human1.24752217
119MYC_22102868_ChIP-Seq_BL_Human1.24628194
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23914831
121AR_20517297_ChIP-Seq_VCAP_Human1.23617257
122NCOR_22424771_ChIP-Seq_293T_Human1.23510609
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.22563791
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22122593
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22052452
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21617776
127* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21104514
128MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20266153
129WT1_19549856_ChIP-ChIP_CCG9911_Human1.17798270
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16836789
131* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16723342
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16705233
133RUNX2_22187159_ChIP-Seq_PCA_Human1.16584098
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16390167
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.15698748
136* GATA3_26560356_Chip-Seq_TH2_Human1.15453309
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14729921
138REST_21632747_ChIP-Seq_MESCs_Mouse1.14313781
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14064831
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13929915
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13258796
142HOXB7_26014856_ChIP-Seq_BT474_Human1.12685381
143SMAD4_21741376_ChIP-Seq_EPCs_Human1.11554378
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11339265
145BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11335497
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10886101
147P53_22387025_ChIP-Seq_ESCs_Mouse1.09994504
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09599236
149NANOG_18555785_Chip-Seq_ESCs_Mouse1.09399261
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09372528
151ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09255810
152MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08679804
153* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08673316
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08600593
155CBX2_27304074_Chip-Seq_ESCs_Mouse1.08237522
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07311121
157GATA1_22025678_ChIP-Seq_K562_Human1.06814039
158STAT3_18555785_Chip-Seq_ESCs_Mouse1.06194042
159SMC4_20622854_ChIP-Seq_HELA_Human1.05268564
160JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05246439
161KDM2B_26808549_Chip-Seq_K562_Human1.04816628
162SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04655452
163AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04497431
164BCL6_27268052_Chip-Seq_Bcells_Human1.04357757
165CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03888563
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03838102
167SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03362566
168P68_20966046_ChIP-Seq_HELA_Human1.03312413
169SPI1_23547873_ChIP-Seq_NB4_Human1.03061421
170RNF2_27304074_Chip-Seq_NSC_Mouse1.02811153
171PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02582910
172PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02520984
173FOXH1_21741376_ChIP-Seq_EPCs_Human1.02277661
174OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01876110
175EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01707642
176GABP_17652178_ChIP-ChIP_JURKAT_Human1.01571860
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99945346
178ELF1_20517297_ChIP-Seq_JURKAT_Human0.99599609
179PRDM14_20953172_ChIP-Seq_ESCs_Human0.99374453
180IRF8_22096565_ChIP-ChIP_GC-B_Human0.98698602
181GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98002250
182GATA1_19941826_ChIP-Seq_K562_Human0.97206723
183RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96372620
184REST_18959480_ChIP-ChIP_MESCs_Mouse0.94302907
185CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93365288
186ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93279093
187MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92193791
188ELK3_25401928_ChIP-Seq_HUVEC_Human0.91247892
189SA1_27219007_Chip-Seq_Bcells_Human0.91149665
190ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88935915
191TET1_21490601_ChIP-Seq_MESCs_Mouse0.88695356
192SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87206884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting7.21625457
2MP0005423_abnormal_somatic_nervous6.28956784
3MP0001986_abnormal_taste_sensitivity4.91962117
4MP0003121_genomic_imprinting4.58931651
5MP0003122_maternal_imprinting4.40442777
6MP0001661_extended_life_span3.58286712
7MP0003195_calcinosis3.50939434
8MP0005645_abnormal_hypothalamus_physiol3.43825137
9MP0000569_abnormal_digit_pigmentation3.20386225
10MP0003763_abnormal_thymus_physiology3.02913973
11MP0006276_abnormal_autonomic_nervous2.69839694
12MP0008961_abnormal_basal_metabolism2.67990266
13MP0008875_abnormal_xenobiotic_pharmacok2.41296529
14MP0005551_abnormal_eye_electrophysiolog2.31107545
15MP0005671_abnormal_response_to2.20607436
16MP0005167_abnormal_blood-brain_barrier2.08677322
17MP0008872_abnormal_physiological_respon2.03805282
18MP0003303_peritoneal_inflammation1.99562642
19MP0005000_abnormal_immune_tolerance1.96340851
20MP0004043_abnormal_pH_regulation1.91789800
21MP0002876_abnormal_thyroid_physiology1.89925225
22MP0002653_abnormal_ependyma_morphology1.88941889
23MP0002138_abnormal_hepatobiliary_system1.88138731
24MP0002102_abnormal_ear_morphology1.82287752
25MP0006072_abnormal_retinal_apoptosis1.81055131
26MP0004147_increased_porphyrin_level1.80646467
27MP0003436_decreased_susceptibility_to1.80551879
28MP0004885_abnormal_endolymph1.77696843
29MP0003300_gastrointestinal_ulcer1.77677358
30MP0003866_abnormal_defecation1.72904737
31MP0005084_abnormal_gallbladder_morpholo1.69109021
32MP0005623_abnormal_meninges_morphology1.64518703
33MP0003329_amyloid_beta_deposits1.64083225
34MP0005253_abnormal_eye_physiology1.63011072
35MP0003252_abnormal_bile_duct1.56430833
36MP0005083_abnormal_biliary_tract1.54880622
37* MP0001800_abnormal_humoral_immune1.53133209
38MP0003787_abnormal_imprinting1.51322060
39MP0006292_abnormal_olfactory_placode1.51017577
40MP0005075_abnormal_melanosome_morpholog1.49598248
41MP0001790_abnormal_immune_system1.49370678
42MP0005387_immune_system_phenotype1.49370678
43MP0005058_abnormal_lysosome_morphology1.47610912
44MP0005646_abnormal_pituitary_gland1.46670675
45* MP0002420_abnormal_adaptive_immunity1.46005779
46MP0002837_dystrophic_cardiac_calcinosis1.45141751
47* MP0001819_abnormal_immune_cell1.43994845
48MP0004142_abnormal_muscle_tone1.43566747
49MP0000685_abnormal_immune_system1.43232708
50MP0003646_muscle_fatigue1.43031089
51MP0002095_abnormal_skin_pigmentation1.42604087
52MP0006082_CNS_inflammation1.42314318
53MP0004742_abnormal_vestibular_system1.40482571
54MP0002272_abnormal_nervous_system1.38574011
55* MP0002723_abnormal_immune_serum1.38169299
56MP0002928_abnormal_bile_duct1.37372793
57MP0002277_abnormal_respiratory_mucosa1.35815700
58MP0001529_abnormal_vocalization1.35802847
59MP0005464_abnormal_platelet_physiology1.34790677
60MP0002148_abnormal_hypersensitivity_rea1.34331189
61MP0001835_abnormal_antigen_presentation1.32979761
62MP0000372_irregular_coat_pigmentation1.31981487
63MP0002398_abnormal_bone_marrow1.31023111
64MP0005174_abnormal_tail_pigmentation1.28986544
65MP0009764_decreased_sensitivity_to1.25165835
66MP0002419_abnormal_innate_immunity1.21965507
67MP0005389_reproductive_system_phenotype1.21690587
68MP0002163_abnormal_gland_morphology1.20194892
69MP0005085_abnormal_gallbladder_physiolo1.19988305
70MP0001486_abnormal_startle_reflex1.19339547
71MP0002733_abnormal_thermal_nociception1.17669589
72* MP0002452_abnormal_antigen_presenting1.17669130
73MP0010155_abnormal_intestine_physiology1.16678266
74MP0001984_abnormal_olfaction1.16194316
75MP0000703_abnormal_thymus_morphology1.15029613
76MP0001919_abnormal_reproductive_system1.13742540
77MP0000858_altered_metastatic_potential1.12523283
78MP0000604_amyloidosis1.12169620
79MP0002938_white_spotting1.12099478
80MP0003959_abnormal_lean_body1.10333116
81MP0002254_reproductive_system_inflammat1.10135436
82MP0005025_abnormal_response_to1.09703537
83MP0000716_abnormal_immune_system1.08934976
84MP0004924_abnormal_behavior1.08912740
85MP0005386_behavior/neurological_phenoty1.08912740
86MP0001485_abnormal_pinna_reflex1.07825047
87MP0002722_abnormal_immune_system1.06646516
88MP0000631_abnormal_neuroendocrine_gland1.06356656
89MP0009379_abnormal_foot_pigmentation1.06162377
90MP0003635_abnormal_synaptic_transmissio1.05422329
91MP0003136_yellow_coat_color1.04800332
92MP0005535_abnormal_body_temperature1.02573583
93MP0002405_respiratory_system_inflammati1.02319550
94MP0002557_abnormal_social/conspecific_i1.01028934
95MP0003011_delayed_dark_adaptation1.00856202
96MP0005379_endocrine/exocrine_gland_phen1.00255982
97MP0002067_abnormal_sensory_capabilities0.97583558
98MP0008877_abnormal_DNA_methylation0.97337234
99MP0000230_abnormal_systemic_arterial0.96282297
100MP0005448_abnormal_energy_balance0.95256502
101MP0003045_fibrosis0.93870483
102MP0005365_abnormal_bile_salt0.93761045
103MP0004133_heterotaxia0.93599184
104MP0004947_skin_inflammation0.93294828
105MP0003724_increased_susceptibility_to0.93005202
106MP0003690_abnormal_glial_cell0.92607499
107MP0005195_abnormal_posterior_eye0.92532984
108MP0004808_abnormal_hematopoietic_stem0.91854231
109MP0000465_gastrointestinal_hemorrhage0.91646608
110MP0004510_myositis0.90184611
111MP0000383_abnormal_hair_follicle0.89343198
112MP0003075_altered_response_to0.88773773
113MP0001905_abnormal_dopamine_level0.88547165
114MP0003566_abnormal_cell_adhesion0.88517470
115MP0002064_seizures0.88488913
116MP0009333_abnormal_splenocyte_physiolog0.88358528
117MP0000015_abnormal_ear_pigmentation0.87392415
118MP0002693_abnormal_pancreas_physiology0.87193583
119MP0002735_abnormal_chemical_nociception0.85914772
120MP0002909_abnormal_adrenal_gland0.85771971
121MP0000647_abnormal_sebaceous_gland0.85531532
122MP0002166_altered_tumor_susceptibility0.85360319
123* MP0001845_abnormal_inflammatory_respons0.85299988
124MP0000689_abnormal_spleen_morphology0.85162499
125MP0005165_increased_susceptibility_to0.84550419
126MP0002160_abnormal_reproductive_system0.84164077
127MP0002009_preneoplasia0.83946476
128MP0001970_abnormal_pain_threshold0.83834732
129MP0005410_abnormal_fertilization0.81753415
130MP0005451_abnormal_body_composition0.81609142
131MP0009672_abnormal_birth_weight0.81351341
132MP0000427_abnormal_hair_cycle0.79826467
133MP0002429_abnormal_blood_cell0.79641087
134MP0001502_abnormal_circadian_rhythm0.78949543
135MP0010386_abnormal_urinary_bladder0.78909152
136MP0010329_abnormal_lipoprotein_level0.78199911
137MP0008775_abnormal_heart_ventricle0.76395032
138MP0001501_abnormal_sleep_pattern0.76101742
139MP0009745_abnormal_behavioral_response0.73663966
140MP0004859_abnormal_synaptic_plasticity0.73059917
141MP0002006_tumorigenesis0.72862719
142MP0002736_abnormal_nociception_after0.72449189
143MP0003698_abnormal_male_reproductive0.71676512
144MP0010234_abnormal_vibrissa_follicle0.71619926
145MP0001324_abnormal_eye_pigmentation0.71353385
146MP0002063_abnormal_learning/memory/cond0.71340687
147MP0001968_abnormal_touch/_nociception0.71173219
148MP0004130_abnormal_muscle_cell0.69837186
149MP0000249_abnormal_blood_vessel0.69784818
150MP0003880_abnormal_central_pattern0.67888142
151MP0009785_altered_susceptibility_to0.65086343
152MP0005310_abnormal_salivary_gland0.63274582
153MP0009046_muscle_twitch0.62640523
154MP0002396_abnormal_hematopoietic_system0.62446704
155MP0002572_abnormal_emotion/affect_behav0.61045189
156MP0001851_eye_inflammation0.60723750
157MP0001440_abnormal_grooming_behavior0.59657339
158* MP0008469_abnormal_protein_level0.58643349
159MP0005166_decreased_susceptibility_to0.57950857
160MP0001533_abnormal_skeleton_physiology0.55692540
161MP0002638_abnormal_pupillary_reflex0.55267590
162MP0008770_decreased_survivor_rate0.54841507
163MP0010352_gastrointestinal_tract_polyps0.52437750

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)5.99832177
2Abnormal hair whorl (HP:0010721)5.88232838
3Oligomenorrhea (HP:0000876)5.65954356
4Hemiplegia (HP:0002301)5.56540857
5Failure to thrive in infancy (HP:0001531)5.06937781
6Abnormality of the labia minora (HP:0012880)5.06199077
7Petechiae (HP:0000967)4.78267653
8Nasal polyposis (HP:0100582)4.59474334
9Focal motor seizures (HP:0011153)4.41628898
10Increased IgE level (HP:0003212)4.36303841
11Purpura (HP:0000979)4.24156074
12Pancreatic cysts (HP:0001737)4.07355162
13Congenital stationary night blindness (HP:0007642)4.00581016
14IgM deficiency (HP:0002850)4.00291617
15Abnormal platelet volume (HP:0011876)3.96729883
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.92944087
17Absent/shortened dynein arms (HP:0200106)3.92944087
18Anomalous pulmonary venous return (HP:0010772)3.92108660
19Type II lissencephaly (HP:0007260)3.88101511
20Pancreatic fibrosis (HP:0100732)3.78777466
21Narrow nasal bridge (HP:0000446)3.71015701
22Abnormality of the nasal mucosa (HP:0000433)3.69937704
23Hip dysplasia (HP:0001385)3.64488440
24Prolonged bleeding time (HP:0003010)3.59026453
25Abnormality of midbrain morphology (HP:0002418)3.58455847
26Molar tooth sign on MRI (HP:0002419)3.58455847
27Diplopia (HP:0000651)3.54232960
28Abnormality of binocular vision (HP:0011514)3.54232960
29Gingival bleeding (HP:0000225)3.51561885
30True hermaphroditism (HP:0010459)3.49679281
31Hemiparesis (HP:0001269)3.47649874
32Abnormal eating behavior (HP:0100738)3.41390304
33Abnormality of the renal cortex (HP:0011035)3.38200735
34Abnormality of the pulmonary veins (HP:0011718)3.32238326
35Nephronophthisis (HP:0000090)3.31256017
36Atonic seizures (HP:0010819)3.20474994
37Abolished electroretinogram (ERG) (HP:0000550)3.18664922
38Spontaneous hematomas (HP:0007420)3.15478931
39Abnormality of the renal medulla (HP:0100957)3.13074884
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.06444696
41Submucous cleft hard palate (HP:0000176)3.05015639
42Sleep apnea (HP:0010535)2.99998130
43Abnormal rod and cone electroretinograms (HP:0008323)2.98178002
44Attenuation of retinal blood vessels (HP:0007843)2.96539149
45Chronic obstructive pulmonary disease (HP:0006510)2.96291486
46Obstructive lung disease (HP:0006536)2.96291486
47Hypoventilation (HP:0002791)2.94840180
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94071931
49Medial flaring of the eyebrow (HP:0010747)2.90597195
50Tubular atrophy (HP:0000092)2.85673281
51Cerebellar dysplasia (HP:0007033)2.85533129
52Hyperventilation (HP:0002883)2.84092112
53Poor suck (HP:0002033)2.76355140
54Abnormal drinking behavior (HP:0030082)2.76215740
55Polydipsia (HP:0001959)2.76215740
56Cortical visual impairment (HP:0100704)2.72877018
57Pendular nystagmus (HP:0012043)2.72141170
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72088637
59Decreased central vision (HP:0007663)2.70810139
60Decreased muscle mass (HP:0003199)2.68825450
61Generalized hypotonia (HP:0001290)2.68538632
62Menorrhagia (HP:0000132)2.66991493
63Asplenia (HP:0001746)2.66882884
64Keratoconus (HP:0000563)2.61235279
65Increased corneal curvature (HP:0100692)2.61235279
66Abnormality of the nasal septum (HP:0000419)2.59805583
67Abnormal pupillary function (HP:0007686)2.56525013
68Status epilepticus (HP:0002133)2.56488759
69Impaired platelet aggregation (HP:0003540)2.55424850
70Abnormal platelet function (HP:0011869)2.55424850
71Recurrent bronchitis (HP:0002837)2.51060902
72Lissencephaly (HP:0001339)2.50930233
73Increased mean platelet volume (HP:0011877)2.49777212
74Thyroiditis (HP:0100646)2.49111420
75Abnormality of B cell number (HP:0010975)2.47944773
76Chronic otitis media (HP:0000389)2.46621883
77Epistaxis (HP:0000421)2.44888125
78Cerebral aneurysm (HP:0004944)2.42991444
79Myokymia (HP:0002411)2.42146465
80Labial hypoplasia (HP:0000066)2.40963387
81Polyuria (HP:0000103)2.40080396
82Generalized hypopigmentation (HP:0007513)2.38389640
83Progressive inability to walk (HP:0002505)2.37974150
84Inability to walk (HP:0002540)2.36747187
85Eczematoid dermatitis (HP:0000976)2.35898827
86Retrobulbar optic neuritis (HP:0100654)2.34580835
87Optic neuritis (HP:0100653)2.34580835
88Congenital malformation of the right heart (HP:0011723)2.34197249
89Double outlet right ventricle (HP:0001719)2.34197249
90Stomach cancer (HP:0012126)2.34088667
91Cystic liver disease (HP:0006706)2.33055786
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.32716404
93Hypercortisolism (HP:0001578)2.31410908
94Abnormality of alanine metabolism (HP:0010916)2.29769373
95Hyperalaninemia (HP:0003348)2.29769373
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29769373
97Concave nail (HP:0001598)2.26164689
98Inflammation of the large intestine (HP:0002037)2.26069652
99Hypergammaglobulinemia (HP:0010702)2.25422726
100Abnormal respiratory motile cilium physiology (HP:0012261)2.23929615
101Fair hair (HP:0002286)2.23721582
102Gaze-evoked nystagmus (HP:0000640)2.22828325
103Chronic hepatic failure (HP:0100626)2.22616878
104Congenital, generalized hypertrichosis (HP:0004540)2.22094803
105Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21647642
106Supranuclear gaze palsy (HP:0000605)2.20668340
107Supernumerary spleens (HP:0009799)2.20267686
108Gait imbalance (HP:0002141)2.16149247
109Iris hypopigmentation (HP:0007730)2.15627662
110Joint hemorrhage (HP:0005261)2.14787955
111Hypothermia (HP:0002045)2.14492319
112Oligodactyly (hands) (HP:0001180)2.14393020
113Gastrointestinal inflammation (HP:0004386)2.13733957
114Hypochromic anemia (HP:0001931)2.12404397
115Renal cortical cysts (HP:0000803)2.10443126
116Febrile seizures (HP:0002373)2.09921468
117Keratoconjunctivitis (HP:0001096)2.09876136
118Bile duct proliferation (HP:0001408)2.09188051
119Abnormal biliary tract physiology (HP:0012439)2.09188051
120Elevated erythrocyte sedimentation rate (HP:0003565)2.09181061
121Growth hormone deficiency (HP:0000824)2.08947300
122Decreased circulating renin level (HP:0003351)2.08064007
123Hypoplastic female external genitalia (HP:0012815)2.07984297
124Congenital primary aphakia (HP:0007707)2.07956709
125Abnormal ciliary motility (HP:0012262)2.03630842
126Bony spicule pigmentary retinopathy (HP:0007737)2.03229614
127Congenital hepatic fibrosis (HP:0002612)2.03073114
128Abnormality of the pons (HP:0007361)2.02869346
129Large for gestational age (HP:0001520)2.01903770
130Sclerocornea (HP:0000647)2.00427360
131Abnormality of T cells (HP:0002843)2.00098487
132Recurrent sinusitis (HP:0011108)1.99021943
133Abnormal respiratory epithelium morphology (HP:0012253)1.98375076
134Abnormal respiratory motile cilium morphology (HP:0005938)1.98375076
135B lymphocytopenia (HP:0010976)1.97521001
136Vasculitis (HP:0002633)1.97399806
137Furrowed tongue (HP:0000221)1.97047597
138Agitation (HP:0000713)1.96749277
139Nephrogenic diabetes insipidus (HP:0009806)1.96657807
140Truncus arteriosus (HP:0001660)1.96232417
141Hypoplasia of the pons (HP:0012110)1.94792948
142Hypoproteinemia (HP:0003075)1.93889448
143Severe combined immunodeficiency (HP:0004430)1.93619492
144Progressive cerebellar ataxia (HP:0002073)1.93564293
145Clumsiness (HP:0002312)1.93301845
146Stomatitis (HP:0010280)1.92980765
147Lymphopenia (HP:0001888)1.92628177
148Hypokalemic alkalosis (HP:0001949)1.92363444
149Orchitis (HP:0100796)1.91895796
150IgG deficiency (HP:0004315)1.91404543
151Abnormality of eosinophils (HP:0001879)1.91358220
152Impaired pain sensation (HP:0007328)1.91010493
153Abnormality of pain sensation (HP:0010832)1.91010493
154Scrotal hypoplasia (HP:0000046)1.90346486
1553-Methylglutaconic aciduria (HP:0003535)1.90239367
156Bronchitis (HP:0012387)1.90160542
157Pachygyria (HP:0001302)1.89829928
158Psychosis (HP:0000709)1.89311754
159Meningitis (HP:0001287)1.89115307
160Myositis (HP:0100614)1.89004609
161Severe muscular hypotonia (HP:0006829)1.88995977
162Infertility (HP:0000789)1.88708467
163Recurrent abscess formation (HP:0002722)1.88547767
164T lymphocytopenia (HP:0005403)1.88122058
165Abnormal number of incisors (HP:0011064)1.87860805
166Abnormal urine output (HP:0012590)1.86848806
167Broad-based gait (HP:0002136)1.86836548
168Generalized tonic-clonic seizures (HP:0002069)1.86559488
169Pulmonary embolism (HP:0002204)1.85896619
170Encephalitis (HP:0002383)1.85363826
171Aplasia/Hypoplasia of the tongue (HP:0010295)1.85000556
172Urticaria (HP:0001025)1.84533180
173Neoplasm of the adrenal cortex (HP:0100641)1.84077819
174Acne (HP:0001061)1.83983182
175Anencephaly (HP:0002323)1.83846380
176Generalized hypopigmentation of hair (HP:0011358)1.83841130
177Chest pain (HP:0100749)1.81367546
178Recurrent fungal infections (HP:0002841)1.81091749
179Ketoacidosis (HP:0001993)1.80211853
180Aplasia/hypoplasia of the uterus (HP:0008684)1.80118816
181Genetic anticipation (HP:0003743)1.79659951
182Increased CSF lactate (HP:0002490)1.79019015
183Congenital sensorineural hearing impairment (HP:0008527)1.77991963
184Absent speech (HP:0001344)1.77918363
185Chorioretinal atrophy (HP:0000533)1.76006427
186Mitochondrial inheritance (HP:0001427)1.74988246
187Adactyly (HP:0009776)1.74846991
188Tubulointerstitial fibrosis (HP:0005576)1.73338144
189Panhypogammaglobulinemia (HP:0003139)1.72073089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.75766433
2TNK24.80650044
3ZAP704.17484830
4TAOK13.59368477
5ARAF3.48734472
6ADRBK23.46632693
7BMPR1B3.25327883
8TXK3.18832453
9NTRK22.98590277
10MST1R2.87745182
11MAP4K12.68291186
12FGFR42.53971790
13MAP3K132.40147343
14ZAK2.36590836
15NUAK12.35816565
16EPHA32.26495587
17WNK32.25327088
18GRK12.23056188
19ACVR1B2.22959604
20MAP4K22.21760240
21ITK2.18634127
22MAP3K91.96041900
23NLK1.95836964
24CAMKK21.94999738
25SYK1.91748822
26EPHB11.91714232
27OXSR11.90350742
28TLK11.87683494
29PINK11.85915892
30SIK21.57995664
31MAPK131.52227854
32JAK11.49895716
33FGFR31.46683980
34STK101.45412716
35NTRK31.44959535
36PTK61.44872392
37KIT1.44068770
38MAP3K121.41438706
39NME21.41201680
40INSRR1.41115510
41MAP3K11.40163270
42PTK2B1.37931843
43KSR21.34788592
44BLK1.29336613
45STK391.29110736
46BTK1.28882669
47SIK11.26906476
48FES1.23205724
49LRRK21.18224646
50MARK31.17800691
51GRK61.17638622
52TYK21.16365874
53TRIB31.15832460
54TNIK1.13460659
55HCK1.12299297
56VRK11.09838035
57SIK31.09802489
58PASK1.04261229
59MKNK21.02293227
60PDK10.98338488
61FGFR20.97378048
62IKBKB0.96008666
63PAK30.95502692
64JAK20.93952268
65CASK0.93290872
66PRKCE0.92441637
67BRAF0.91587025
68LCK0.91037485
69CLK10.89763691
70RAF10.86948354
71PKN20.86735812
72PRKCQ0.84150741
73TRIM280.83812230
74TIE10.83447719
75DYRK20.82911598
76PNCK0.82191605
77WNK40.80355684
78HIPK20.79787254
79CHUK0.79547353
80SGK30.79297553
81PRKCG0.79031074
82MAP3K40.78247084
83RPS6KA20.77570879
84NEK20.76971121
85PDPK10.76483232
86MAP2K60.76355836
87STK110.76203078
88PIM20.76016375
89BMPR20.74649351
90RET0.73011495
91VRK20.72248731
92MST40.70910136
93PIK3CA0.69390759
94CSNK1G20.66997285
95TAF10.64665199
96CAMK1D0.64262062
97ALK0.62726827
98CSK0.62691123
99MAP2K70.62540466
100SGK20.61981317
101CAMK10.59277963
102CSNK1G30.58078651
103EEF2K0.57689828
104TBK10.57270648
105SGK4940.56938969
106SGK2230.56938969
107RIPK40.55954360
108ADRBK10.55856821
109LYN0.55543891
110PRKCH0.55526345
111PRKCI0.54489338
112PLK30.52319718
113CSNK1G10.51723049
114BRSK20.51371120
115GRK70.49129506
116STK30.48402911
117MAP3K70.47916587
118TEC0.47668612
119JAK30.45982127
120MAP2K20.45549483
121BCKDK0.45133843
122CSNK1A1L0.44957856
123LMTK20.44454501
124MARK10.44181426
125TGFBR10.43734425
126GRK50.43393264
127PRKAA20.43257879
128SCYL20.42858376
129MAPK120.41858516
130MOS0.41511885
131IRAK10.41382534
132STK38L0.41343319
133PRKCZ0.41001193
134DAPK20.40965141
135CAMK1G0.39791836
136CAMK2A0.38987261
137CCNB10.38803649
138PRKACA0.38239382
139RPS6KC10.38206556
140RPS6KL10.38206556
141DYRK1A0.37346732
142PKN10.35955040
143PLK20.35450735
144CAMKK10.35419643
145MAP2K10.35261455
146PRKCA0.34524575
147PAK60.34346472
148MAPK70.33892373
149MAPK150.33490868
150RPS6KA50.33091949
151IKBKE0.32163910
152FLT30.31577111
153RPS6KA60.31262597
154PHKG20.30944259
155PHKG10.30944259
156MATK0.29489611
157FYN0.28001569
158IRAK30.27923282
159IRAK40.27529724
160MET0.27261331
161DAPK30.26233754
162TAOK30.26168507
163KSR10.25171522
164TSSK60.24574506
165MINK10.23714782
166ROCK20.23580757

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046143.56737712
2Asthma_Homo sapiens_hsa053103.29238019
3Caffeine metabolism_Homo sapiens_hsa002323.28019238
4Phototransduction_Homo sapiens_hsa047442.98786729
5Nitrogen metabolism_Homo sapiens_hsa009102.77458909
6Linoleic acid metabolism_Homo sapiens_hsa005912.76975270
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.72367224
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59549933
9T cell receptor signaling pathway_Homo sapiens_hsa046602.43948050
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31645226
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31506450
12Primary immunodeficiency_Homo sapiens_hsa053402.28839853
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.19097403
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09523266
15Ether lipid metabolism_Homo sapiens_hsa005652.06131768
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.06039683
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.04008176
18Adipocytokine signaling pathway_Homo sapiens_hsa049202.02168964
19* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00696871
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.00241715
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90457302
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88864206
23Oxidative phosphorylation_Homo sapiens_hsa001901.85458634
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85274290
25Tryptophan metabolism_Homo sapiens_hsa003801.81674722
26Butanoate metabolism_Homo sapiens_hsa006501.79630894
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76590232
28Selenocompound metabolism_Homo sapiens_hsa004501.71915112
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67932122
30Dorso-ventral axis formation_Homo sapiens_hsa043201.63844560
31Taste transduction_Homo sapiens_hsa047421.61425188
32Homologous recombination_Homo sapiens_hsa034401.57797933
33Gastric acid secretion_Homo sapiens_hsa049711.51229730
34Osteoclast differentiation_Homo sapiens_hsa043801.49119578
35Arachidonic acid metabolism_Homo sapiens_hsa005901.43265833
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43199566
37B cell receptor signaling pathway_Homo sapiens_hsa046621.42111022
38Morphine addiction_Homo sapiens_hsa050321.41898606
39GABAergic synapse_Homo sapiens_hsa047271.39488223
40Prion diseases_Homo sapiens_hsa050201.36305659
41Hematopoietic cell lineage_Homo sapiens_hsa046401.34431889
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34244345
43Bile secretion_Homo sapiens_hsa049761.34240923
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34062983
45Platelet activation_Homo sapiens_hsa046111.28985767
46Fanconi anemia pathway_Homo sapiens_hsa034601.28858511
47Parkinsons disease_Homo sapiens_hsa050121.25771250
48Salivary secretion_Homo sapiens_hsa049701.25275299
49Peroxisome_Homo sapiens_hsa041461.24909645
50Dopaminergic synapse_Homo sapiens_hsa047281.21231728
51Chemokine signaling pathway_Homo sapiens_hsa040621.21219043
52Long-term potentiation_Homo sapiens_hsa047201.20934786
53Insulin secretion_Homo sapiens_hsa049111.20916060
54Protein export_Homo sapiens_hsa030601.20568102
55Serotonergic synapse_Homo sapiens_hsa047261.19682786
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.19529720
57RNA polymerase_Homo sapiens_hsa030201.19259153
58Basal transcription factors_Homo sapiens_hsa030221.18205885
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17657502
60Sphingolipid signaling pathway_Homo sapiens_hsa040711.16039511
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.13322479
62Cocaine addiction_Homo sapiens_hsa050301.12678781
63Renin secretion_Homo sapiens_hsa049241.11529044
64Regulation of autophagy_Homo sapiens_hsa041401.10736497
65Vibrio cholerae infection_Homo sapiens_hsa051101.10695826
66Ovarian steroidogenesis_Homo sapiens_hsa049131.10682195
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10223811
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09503333
69Type II diabetes mellitus_Homo sapiens_hsa049301.01246394
70Ribosome_Homo sapiens_hsa030101.00965683
71Synaptic vesicle cycle_Homo sapiens_hsa047211.00524272
72Chemical carcinogenesis_Homo sapiens_hsa052040.99595525
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.98971387
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.98787597
75Allograft rejection_Homo sapiens_hsa053300.98675750
76ABC transporters_Homo sapiens_hsa020100.95007193
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94215274
78Nicotine addiction_Homo sapiens_hsa050330.94183144
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93315185
80Measles_Homo sapiens_hsa051620.92820444
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91177649
82Pancreatic cancer_Homo sapiens_hsa052120.91053529
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88391638
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88309687
85Toxoplasmosis_Homo sapiens_hsa051450.86870775
86RNA degradation_Homo sapiens_hsa030180.86698448
87VEGF signaling pathway_Homo sapiens_hsa043700.84998984
88Olfactory transduction_Homo sapiens_hsa047400.84875701
89Graft-versus-host disease_Homo sapiens_hsa053320.84845211
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84725049
91Estrogen signaling pathway_Homo sapiens_hsa049150.84041205
92MAPK signaling pathway_Homo sapiens_hsa040100.83415237
93Viral myocarditis_Homo sapiens_hsa054160.82877351
94Rheumatoid arthritis_Homo sapiens_hsa053230.82069014
95Glycerolipid metabolism_Homo sapiens_hsa005610.81985286
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81240186
97Acute myeloid leukemia_Homo sapiens_hsa052210.80965831
98Retinol metabolism_Homo sapiens_hsa008300.80907946
99GnRH signaling pathway_Homo sapiens_hsa049120.79637624
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79145068
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79108697
102Alzheimers disease_Homo sapiens_hsa050100.78072366
103Cholinergic synapse_Homo sapiens_hsa047250.77939737
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77835301
105Leishmaniasis_Homo sapiens_hsa051400.77758992
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77737991
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74022251
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73982725
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73637566
110Pancreatic secretion_Homo sapiens_hsa049720.73250791
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.71506785
112Glucagon signaling pathway_Homo sapiens_hsa049220.71009069
113Propanoate metabolism_Homo sapiens_hsa006400.70017974
114Amphetamine addiction_Homo sapiens_hsa050310.69825645
115Huntingtons disease_Homo sapiens_hsa050160.68367864
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.68032164
117Antigen processing and presentation_Homo sapiens_hsa046120.67702263
118Gap junction_Homo sapiens_hsa045400.67061106
119Circadian entrainment_Homo sapiens_hsa047130.66574108
120Prolactin signaling pathway_Homo sapiens_hsa049170.65635604
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65513631
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.65319958
123Collecting duct acid secretion_Homo sapiens_hsa049660.65199580
124Dilated cardiomyopathy_Homo sapiens_hsa054140.63921725
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63827797
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63711785
127Cardiac muscle contraction_Homo sapiens_hsa042600.63357693
128Fat digestion and absorption_Homo sapiens_hsa049750.62267398
129Insulin signaling pathway_Homo sapiens_hsa049100.62092066
130Non-small cell lung cancer_Homo sapiens_hsa052230.60469284
131Glutamatergic synapse_Homo sapiens_hsa047240.59223246
132Oxytocin signaling pathway_Homo sapiens_hsa049210.59187189
133cAMP signaling pathway_Homo sapiens_hsa040240.59041142
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58591127
135Galactose metabolism_Homo sapiens_hsa000520.58181509
136Thyroid hormone synthesis_Homo sapiens_hsa049180.58157845
137Type I diabetes mellitus_Homo sapiens_hsa049400.58009296
138Calcium signaling pathway_Homo sapiens_hsa040200.57456528
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57173871
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56237243
141Autoimmune thyroid disease_Homo sapiens_hsa053200.56067001
142Apoptosis_Homo sapiens_hsa042100.54013893
143Staphylococcus aureus infection_Homo sapiens_hsa051500.53004550
144Histidine metabolism_Homo sapiens_hsa003400.52668018
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.51785843
146Melanogenesis_Homo sapiens_hsa049160.51359922
147Purine metabolism_Homo sapiens_hsa002300.50446107
148NF-kappa B signaling pathway_Homo sapiens_hsa040640.49293852
149Fatty acid biosynthesis_Homo sapiens_hsa000610.48906269
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48676836
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48501357
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48006701
153beta-Alanine metabolism_Homo sapiens_hsa004100.47040427
154Lysosome_Homo sapiens_hsa041420.46883393
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46805574
156Metabolic pathways_Homo sapiens_hsa011000.45031943
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.44620226
158Endocytosis_Homo sapiens_hsa041440.43316426
159Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43279309
160Colorectal cancer_Homo sapiens_hsa052100.42760294
161Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42075532
162One carbon pool by folate_Homo sapiens_hsa006700.39978178
163Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38793710
164Long-term depression_Homo sapiens_hsa047300.36617594
165Mineral absorption_Homo sapiens_hsa049780.36544548
166Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35440894
167Vascular smooth muscle contraction_Homo sapiens_hsa042700.34129000
168Proteasome_Homo sapiens_hsa030500.31943657
169Sulfur metabolism_Homo sapiens_hsa009200.30858126

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