HRNR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.57025300
2* water homeostasis (GO:0030104)9.55273325
3hemidesmosome assembly (GO:0031581)8.56064345
4skin morphogenesis (GO:0043589)7.98642610
5keratinocyte proliferation (GO:0043616)7.47083608
6epidermal cell differentiation (GO:0009913)7.28831645
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.92287121
8long-chain fatty acid biosynthetic process (GO:0042759)6.70430185
9intermediate filament organization (GO:0045109)6.69878995
10epidermis development (GO:0008544)6.21765521
11fatty acid elongation (GO:0030497)5.30322259
12adhesion of symbiont to host cell (GO:0044650)5.28091652
13virion attachment to host cell (GO:0019062)5.28091652
14ectoderm development (GO:0007398)5.18948244
15linoleic acid metabolic process (GO:0043651)4.97289892
16glucosamine-containing compound catabolic process (GO:1901072)4.88534341
17skin development (GO:0043588)4.72976915
18intermediate filament cytoskeleton organization (GO:0045104)4.52149709
19regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.40230279
20intermediate filament-based process (GO:0045103)4.39386856
21adhesion of symbiont to host (GO:0044406)4.27085168
22fibrinolysis (GO:0042730)4.15735391
23surfactant homeostasis (GO:0043129)4.09039709
24lipoxygenase pathway (GO:0019372)3.91071278
25gap junction assembly (GO:0016264)3.90076530
26establishment of protein localization to Golgi (GO:0072600)3.77113470
27phospholipid efflux (GO:0033700)3.69077296
28chemical homeostasis within a tissue (GO:0048875)3.54902792
29retrograde transport, vesicle recycling within Golgi (GO:0000301)3.52324380
30metanephric nephron tubule development (GO:0072234)3.46237959
31metanephric tubule development (GO:0072170)3.46237959
32protein targeting to Golgi (GO:0000042)3.40586314
33positive regulation of cholesterol efflux (GO:0010875)3.39070906
34metanephric nephron epithelium development (GO:0072243)3.38952994
35negative regulation of cell fate specification (GO:0009996)3.30673490
36long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.29590503
37nephron tubule formation (GO:0072079)3.19988142
38keratinocyte development (GO:0003334)3.17729318
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14272272
40mesodermal cell differentiation (GO:0048333)3.11004404
41metanephric epithelium development (GO:0072207)3.09494259
42positive regulation of Rho protein signal transduction (GO:0035025)3.09287461
43smooth muscle tissue development (GO:0048745)3.04296493
44cell-substrate junction assembly (GO:0007044)3.02955004
45atrioventricular valve morphogenesis (GO:0003181)3.00725962
46positive regulation of sterol transport (GO:0032373)3.00336097
47positive regulation of cholesterol transport (GO:0032376)3.00336097
48* keratinization (GO:0031424)23.3412275
49* establishment of skin barrier (GO:0061436)21.4292563
50phosphatidylinositol acyl-chain remodeling (GO:0036149)2.98651377
51fibroblast migration (GO:0010761)2.96297478
52regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.94601198
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.91872228
54regulation of hippo signaling (GO:0035330)2.90525934
55regulation of ruffle assembly (GO:1900027)2.89289309
56epithelium development (GO:0060429)2.89137285
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.87567000
58negative regulation of metanephros development (GO:0072217)2.87156882
59detection of bacterium (GO:0016045)2.86894904
60regulation of protein polyubiquitination (GO:1902914)2.86738883
61sequestering of metal ion (GO:0051238)2.82589199
62ventricular cardiac muscle cell action potential (GO:0086005)2.81801147
63positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.79679962
64establishment of tissue polarity (GO:0007164)2.78540650
65establishment of planar polarity (GO:0001736)2.78540650
66interkinetic nuclear migration (GO:0022027)2.77276739
67regulation of phospholipase A2 activity (GO:0032429)2.75558844
68hormone catabolic process (GO:0042447)2.74972148
69fatty-acyl-CoA metabolic process (GO:0035337)2.73509920
70fatty-acyl-CoA biosynthetic process (GO:0046949)2.73011424
71cytoskeletal anchoring at plasma membrane (GO:0007016)2.72326648
72retina homeostasis (GO:0001895)2.71283218
73sphingosine metabolic process (GO:0006670)2.70593269
74nephron tubule development (GO:0072080)2.69055711
75protein heterotrimerization (GO:0070208)2.67833715
76glomerular basement membrane development (GO:0032836)2.67818733
77mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.65962259
78renal tubule development (GO:0061326)2.64566722
79epithelial cell-cell adhesion (GO:0090136)2.64491485
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61372077
81regulation of cardioblast differentiation (GO:0051890)2.59503115
82renal filtration (GO:0097205)2.57991087
83lipid translocation (GO:0034204)2.57199257
84phospholipid translocation (GO:0045332)2.57199257
85regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.56980537
86cellular response to calcium ion (GO:0071277)2.55858173
87phosphatidylserine acyl-chain remodeling (GO:0036150)2.53351192
88artery development (GO:0060840)2.52590960
89negative regulation of cell fate commitment (GO:0010454)2.52078075
90negative regulation of stress fiber assembly (GO:0051497)2.49400348
91maintenance of gastrointestinal epithelium (GO:0030277)2.47964209
92negative regulation of keratinocyte proliferation (GO:0010839)2.47507952
93hair cell differentiation (GO:0035315)2.47014294
94regulation of keratinocyte proliferation (GO:0010837)2.46533849
95regulation of cholesterol efflux (GO:0010874)2.45814263
96collagen fibril organization (GO:0030199)2.45035509
97very long-chain fatty acid metabolic process (GO:0000038)2.45021149
98regulation of T cell chemotaxis (GO:0010819)2.43927223
99positive regulation of T cell chemotaxis (GO:0010820)2.43927223
100detection of other organism (GO:0098543)2.43439663
101cellular response to ethanol (GO:0071361)2.43062746
102intestinal epithelial cell development (GO:0060576)2.42942965
103actin filament depolymerization (GO:0030042)2.42839174
104polarized epithelial cell differentiation (GO:0030859)2.41548202
105sphingoid metabolic process (GO:0046519)2.40504531
106non-canonical Wnt signaling pathway (GO:0035567)2.39773451
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.38441600
108diol metabolic process (GO:0034311)2.38373533
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38236878
110regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.37131598
111protein localization to Golgi apparatus (GO:0034067)2.36803845
112extracellular fibril organization (GO:0043206)2.36104657
113myoblast fusion (GO:0007520)2.36102076
114regulation of Rho protein signal transduction (GO:0035023)2.35816281
115plasma membrane repair (GO:0001778)2.35595735
116cytoplasmic mRNA processing body assembly (GO:0033962)2.34724693
117polyol transport (GO:0015791)2.34686575
118regulation of transforming growth factor beta1 production (GO:0032908)2.33443755
119regulation of protein localization to cell surface (GO:2000008)2.32927928
120regulation of heart rate by cardiac conduction (GO:0086091)2.32690193
121cell communication involved in cardiac conduction (GO:0086065)2.31547091
122genitalia morphogenesis (GO:0035112)2.30652909
123bone trabecula formation (GO:0060346)2.27761851
124skeletal muscle adaptation (GO:0043501)2.26904277
125cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.26819752
126syncytium formation by plasma membrane fusion (GO:0000768)2.26295785
127nucleus localization (GO:0051647)2.25436804
128lymphangiogenesis (GO:0001946)2.25095069
129macroautophagy (GO:0016236)2.24928662
130cell adhesion mediated by integrin (GO:0033627)2.23925757
131nephron epithelium development (GO:0072009)2.23382330
132inositol phosphate-mediated signaling (GO:0048016)2.22679128
133Notch signaling involved in heart development (GO:0061314)2.22567325
134lateral sprouting from an epithelium (GO:0060601)2.21245318
135negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.20978121
136regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.20738378
137cell wall macromolecule catabolic process (GO:0016998)2.19966999
138cell wall macromolecule metabolic process (GO:0044036)2.19966999
139protein K48-linked deubiquitination (GO:0071108)2.18856998
140collagen metabolic process (GO:0032963)2.17838736
141regulation of transforming growth factor beta2 production (GO:0032909)2.16426840
142negative regulation of protein kinase B signaling (GO:0051898)2.14984843
143collagen catabolic process (GO:0030574)2.13774510
144wound healing (GO:0042060)2.12657554
145phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.12033768
146multicellular organismal macromolecule metabolic process (GO:0044259)2.09992629
147phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.04748183
148extracellular matrix disassembly (GO:0022617)2.03873670
149gland morphogenesis (GO:0022612)2.01635874
150hair follicle development (GO:0001942)2.00948803
151* regulation of water loss via skin (GO:0033561)18.1224158
152desmosome organization (GO:0002934)12.9144207
153* multicellular organismal water homeostasis (GO:0050891)11.6122333
154hair cycle (GO:0042633)10.4720593
155molting cycle (GO:0042303)10.4720593
156peptide cross-linking (GO:0018149)10.0117211
157male genitalia development (GO:0030539)1.99576827
158regulation of natural killer cell differentiation (GO:0032823)1.99512282
159acyl-CoA biosynthetic process (GO:0071616)1.99136377
160thioester biosynthetic process (GO:0035384)1.99136377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.66843324
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.59187138
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.74700320
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64596603
5ZNF263_19887448_ChIP-Seq_K562_Human2.50049707
6FOXO3_23340844_ChIP-Seq_DLD1_Human2.24252972
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.22754166
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15036310
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14115065
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.12235970
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07644174
12GBX2_23144817_ChIP-Seq_PC3_Human2.06614191
13TP63_17297297_ChIP-ChIP_HaCaT_Human13.0264826
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99326626
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99326626
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97360244
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89725057
18CTNNB1_20460455_ChIP-Seq_HCT116_Human1.88716600
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.88538283
20* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.79962602
21TP63_23658742_ChIP-Seq_EP156T_Human1.75709962
22AR_21572438_ChIP-Seq_LNCaP_Human1.74846673
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.72351626
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72325210
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70935380
26* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70501190
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.64335387
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.62010298
29* GATA6_21074721_ChIP-Seq_CACO-2_Human1.61299522
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61150973
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61092941
32* TP63_22573176_ChIP-Seq_HFKS_Human1.58591892
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.56773802
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55670506
35GATA1_22025678_ChIP-Seq_K562_Human1.52115246
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51858545
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50186038
38RXR_22108803_ChIP-Seq_LS180_Human1.50128577
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.48239034
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43208222
41DROSHA_22980978_ChIP-Seq_HELA_Human1.42151051
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41536847
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41422854
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.40864819
45CTCF_27219007_Chip-Seq_Bcells_Human1.40013645
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.37057910
47STAT3_23295773_ChIP-Seq_U87_Human1.36394007
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35601946
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35285001
50CJUN_26792858_Chip-Seq_BT549_Human1.34304042
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31945449
52SMAD3_21741376_ChIP-Seq_HESCs_Human1.30515017
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30506358
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29482144
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.29239515
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.28897861
57TP53_18474530_ChIP-ChIP_U2OS_Human1.28304550
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27760164
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27358990
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27216185
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26321533
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26321533
63ATF3_27146783_Chip-Seq_COLON_Human1.26114393
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25490615
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24706683
66KLF5_25053715_ChIP-Seq_YYC3_Human1.23017422
67TCF4_23295773_ChIP-Seq_U87_Human1.22918235
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22274304
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21951335
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21937420
71ERG_20517297_ChIP-Seq_VCAP_Human1.21654238
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20586599
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19652506
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18650570
75CEBPB_22108803_ChIP-Seq_LS180_Human1.16970908
76RACK7_27058665_Chip-Seq_MCF-7_Human1.16270561
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.15427553
78* E2F1_20622854_ChIP-Seq_HELA_Human1.12320256
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11520318
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.11486119
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10831436
82TP53_16413492_ChIP-PET_HCT116_Human1.10642454
83SOX2_20726797_ChIP-Seq_SW620_Human1.10260458
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09177996
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06607198
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06548436
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04928187
88BRD4_25478319_ChIP-Seq_HGPS_Human1.04897257
89OCT1_27270436_Chip-Seq_PROSTATE_Human1.04882859
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04285562
91LXR_22292898_ChIP-Seq_THP-1_Human1.02577588
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.02414851
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01854534
94* CTCF_20526341_ChIP-Seq_ESCs_Human1.01099620
95* BCOR_27268052_Chip-Seq_Bcells_Human1.01068519
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00314526
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.00197292
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99880642
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99021403
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98976131
101AR_25329375_ChIP-Seq_VCAP_Human0.98838149
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98408608
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.97023570
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96511370
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.96467224
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96039339
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94772222
108* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94533541
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.94515047
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.94369604
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94254830
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93216118
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92950703
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91416981
115CDX2_22108803_ChIP-Seq_LS180_Human0.91364300
116KDM2B_26808549_Chip-Seq_K562_Human0.91091258
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90775396
118* HNFA_21074721_ChIP-Seq_CACO-2_Human0.90592348
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.89649668
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88651618
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88142929
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.87540705
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.86601125
124* RBPJ_21746931_ChIP-Seq_IB4_Human0.86340098
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.85806140
126BCL6_27268052_Chip-Seq_Bcells_Human0.85606302
127TAF2_19829295_ChIP-Seq_ESCs_Human0.85178231
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85169923
129* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85132707
130RNF2_27304074_Chip-Seq_ESCs_Mouse0.84525168
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84165277
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84165277
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.83933789
134AHR_22903824_ChIP-Seq_MCF-7_Human0.83187133
135JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82140783
136GATA4_25053715_ChIP-Seq_YYC3_Human0.82063436
137JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81666797
138JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80497176
139SA1_27219007_Chip-Seq_ERYTHROID_Human0.79549927
140* P68_20966046_ChIP-Seq_HELA_Human0.79387627
141SMC4_20622854_ChIP-Seq_HELA_Human0.78534913
142SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78215188
143MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.78070458
144* SMAD4_21741376_ChIP-Seq_ESCs_Human0.77959926
145GATA6_25053715_ChIP-Seq_YYC3_Human0.77059358
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76940739
147TBX20_22080862_ChIP-Seq_HEART_Mouse0.76661233
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.76661233
149* BCAT_22108803_ChIP-Seq_LS180_Human0.75723794
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75532431
151FOXH1_21741376_ChIP-Seq_ESCs_Human0.75084393
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74931333
153P53_21459846_ChIP-Seq_SAOS-2_Human0.74896270
154KDM2B_26808549_Chip-Seq_JURKAT_Human0.74520499
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74224903
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74035402
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.73514204
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.73126125
159GATA2_19941826_ChIP-Seq_K562_Human0.73094022
160* YY1_22570637_ChIP-Seq_MALME-3M_Human0.71579152
161* TCF4_22108803_ChIP-Seq_LS180_Human0.70106515
162EZH2_27304074_Chip-Seq_ESCs_Mouse0.69798480
163EGR1_19032775_ChIP-ChIP_M12_Human0.69768472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.85090385
2MP0005275_abnormal_skin_tensile7.80545720
3MP0005501_abnormal_skin_physiology5.41287486
4MP0000579_abnormal_nail_morphology4.97387603
5MP0002138_abnormal_hepatobiliary_system4.42361647
6MP0009379_abnormal_foot_pigmentation4.04109855
7MP0010234_abnormal_vibrissa_follicle3.83106915
8MP0003705_abnormal_hypodermis_morpholog3.59942516
9MP0003941_abnormal_skin_development3.59049236
10MP0002060_abnormal_skin_morphology3.50147530
11MP0004947_skin_inflammation3.37857863
12MP0001216_abnormal_epidermal_layer3.34073735
13MP0010771_integument_phenotype3.18895893
14MP0001188_hyperpigmentation3.03373672
15MP0000569_abnormal_digit_pigmentation2.87440072
16MP0002254_reproductive_system_inflammat2.66036215
17MP0005451_abnormal_body_composition2.62692242
18MP0005377_hearing/vestibular/ear_phenot2.62479062
19MP0003878_abnormal_ear_physiology2.62479062
20MP0000647_abnormal_sebaceous_gland2.62101705
21MP0000383_abnormal_hair_follicle2.58644799
22MP0010678_abnormal_skin_adnexa2.48447030
23MP0004381_abnormal_hair_follicle2.33931673
24MP0008438_abnormal_cutaneous_collagen2.31481248
25MP0003300_gastrointestinal_ulcer2.29267722
26MP0004885_abnormal_endolymph2.21910627
27MP0000427_abnormal_hair_cycle2.19395041
28MP0000377_abnormal_hair_follicle2.06839165
29MP0003191_abnormal_cellular_cholesterol1.99195914
30MP0003453_abnormal_keratinocyte_physiol1.97764065
31MP0000467_abnormal_esophagus_morphology1.93502968
32MP0002098_abnormal_vibrissa_morphology1.91426569
33MP0005171_absent_coat_pigmentation1.88024625
34MP0009931_abnormal_skin_appearance1.86515691
35MP0003252_abnormal_bile_duct1.67931295
36MP0001243_abnormal_dermal_layer1.65994813
37MP0003091_abnormal_cell_migration1.62853098
38MP0002095_abnormal_skin_pigmentation1.62062138
39MP0002168_other_aberrant_phenotype1.53293806
40MP0001191_abnormal_skin_condition1.52196255
41MP0000762_abnormal_tongue_morphology1.49655087
42MP0005174_abnormal_tail_pigmentation1.46418642
43MP0008004_abnormal_stomach_pH1.45963811
44MP0003566_abnormal_cell_adhesion1.41493140
45MP0004185_abnormal_adipocyte_glucose1.34554953
46MP0002928_abnormal_bile_duct1.33522130
47MP0005409_darkened_coat_color1.29019640
48MP0000015_abnormal_ear_pigmentation1.22002813
49MP0002177_abnormal_outer_ear1.19974459
50MP0010368_abnormal_lymphatic_system1.18335438
51MP0000367_abnormal_coat/_hair1.18214281
52MP0002234_abnormal_pharynx_morphology1.10550646
53MP0003879_abnormal_hair_cell1.00402921
54MP0004510_myositis0.97718673
55MP0005408_hypopigmentation0.97277620
56MP0004782_abnormal_surfactant_physiolog0.94341670
57MP0001851_eye_inflammation0.93545321
58MP0001661_extended_life_span0.93514187
59MP0000371_diluted_coat_color0.83659849
60MP0001346_abnormal_lacrimal_gland0.77262344
61MP0001784_abnormal_fluid_regulation0.76475439
62MP0003279_aneurysm0.76374858
63MP0001756_abnormal_urination0.73040435
64MP0004036_abnormal_muscle_relaxation0.72331666
65MP0010030_abnormal_orbit_morphology0.69825473
66MP0001849_ear_inflammation0.68267285
67MP0010386_abnormal_urinary_bladder0.68006521
68MP0000465_gastrointestinal_hemorrhage0.66734166
69MP0000566_synostosis0.66609401
70MP0001485_abnormal_pinna_reflex0.66303287
71MP0004084_abnormal_cardiac_muscle0.64312921
72MP0001340_abnormal_eyelid_morphology0.63875264
73MP0004043_abnormal_pH_regulation0.63506112
74MP0001879_abnormal_lymphatic_vessel0.62708346
75MP0005023_abnormal_wound_healing0.59129025
76MP0001958_emphysema0.56926826
77MP0008057_abnormal_DNA_replication0.56232630
78MP0005220_abnormal_exocrine_pancreas0.54831708
79MP0000537_abnormal_urethra_morphology0.54627377
80MP0009333_abnormal_splenocyte_physiolog0.52638155
81MP0002075_abnormal_coat/hair_pigmentati0.52406236
82MP0005395_other_phenotype0.52209828
83MP0005503_abnormal_tendon_morphology0.51473537
84MP0002269_muscular_atrophy0.51415144
85MP0005257_abnormal_intraocular_pressure0.49283903
86MP0008961_abnormal_basal_metabolism0.47308301
87MP0009053_abnormal_anal_canal0.46929853
88MP0000013_abnormal_adipose_tissue0.45792805
89MP0004134_abnormal_chest_morphology0.44177340
90MP0000747_muscle_weakness0.43806108
91MP0003943_abnormal_hepatobiliary_system0.43191060
92MP0001177_atelectasis0.42199444
93MP0000534_abnormal_ureter_morphology0.40868768
94MP0009780_abnormal_chondrocyte_physiolo0.40604362
95MP0000767_abnormal_smooth_muscle0.40387642
96MP0002111_abnormal_tail_morphology0.39893099
97MP0002332_abnormal_exercise_endurance0.39145089
98MP0005666_abnormal_adipose_tissue0.39106483
99MP0006054_spinal_hemorrhage0.37919061
100MP0000751_myopathy0.37470557
101MP0003950_abnormal_plasma_membrane0.36939796
102MP0010352_gastrointestinal_tract_polyps0.36825421
103MP0009672_abnormal_birth_weight0.35129996
104MP0001299_abnormal_eye_distance/0.34202624
105MP0003755_abnormal_palate_morphology0.33496732
106MP0000627_abnormal_mammary_gland0.33177605
107MP0002166_altered_tumor_susceptibility0.32212610
108MP0005076_abnormal_cell_differentiation0.32188268
109MP0005388_respiratory_system_phenotype0.30315268
110MP0002133_abnormal_respiratory_system0.30315268
111MP0002009_preneoplasia0.30169326
112MP0004272_abnormal_basement_membrane0.29979917
113MP0002877_abnormal_melanocyte_morpholog0.29360288
114MP0002006_tumorigenesis0.28373069
115MP0005375_adipose_tissue_phenotype0.26546685
116MP0000538_abnormal_urinary_bladder0.26545585
117MP0002697_abnormal_eye_size0.25829846
118MP0003045_fibrosis0.25821843
119MP0000432_abnormal_head_morphology0.25290487
120MP0002282_abnormal_trachea_morphology0.23821822
121MP0003329_amyloid_beta_deposits0.21901324
122MP0003448_altered_tumor_morphology0.19467626
123MP0002108_abnormal_muscle_morphology0.19082149
124MP0002233_abnormal_nose_morphology0.18962468
125MP0003385_abnormal_body_wall0.18734663
126MP0000428_abnormal_craniofacial_morphol0.18516391
127MP0000462_abnormal_digestive_system0.18252544
128MP0002896_abnormal_bone_mineralization0.17885447
129MP0001186_pigmentation_phenotype0.17711055
130MP0000749_muscle_degeneration0.17436131
131MP0004130_abnormal_muscle_cell0.15447063
132MP0005508_abnormal_skeleton_morphology0.15440135
133MP0009384_cardiac_valve_regurgitation0.14875372
134MP0004197_abnormal_fetal_growth/weight/0.14374731
135MP0004264_abnormal_extraembryonic_tissu0.13701350
136MP0000733_abnormal_muscle_development0.13402478
137MP0002249_abnormal_larynx_morphology0.12146722
138MP0002109_abnormal_limb_morphology0.11412125
139MP0002971_abnormal_brown_adipose0.10989974

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)8.33046969
2Conjunctival hamartoma (HP:0100780)8.29055589
3Palmoplantar hyperkeratosis (HP:0000972)7.50071714
4Congenital ichthyosiform erythroderma (HP:0007431)7.24270728
5Palmar hyperkeratosis (HP:0010765)7.16742425
6Plantar hyperkeratosis (HP:0007556)7.00273815
7Hypotrichosis (HP:0001006)6.79282644
8Erythroderma (HP:0001019)6.51468713
9Erythema (HP:0010783)5.99305030
10Onycholysis (HP:0001806)5.93459549
11Eczematoid dermatitis (HP:0000976)5.62761726
12Abnormality of the axillary hair (HP:0100134)5.54636357
13Abnormality of secondary sexual hair (HP:0009888)5.54636357
14Hamartoma of the eye (HP:0010568)5.45408951
15Thick nail (HP:0001805)5.40567528
16Pili torti (HP:0003777)5.31159596
17Woolly hair (HP:0002224)5.31141844
18Gangrene (HP:0100758)4.96698691
19Right ventricular cardiomyopathy (HP:0011663)4.92505306
20Alopecia of scalp (HP:0002293)4.87345311
21Follicular hyperkeratosis (HP:0007502)4.72284340
22Abnormal blistering of the skin (HP:0008066)4.57385832
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.42537774
24Milia (HP:0001056)4.18300286
25Ectropion (HP:0000656)3.94359520
26Fragile nails (HP:0001808)3.82774726
27Atrophic scars (HP:0001075)3.78176437
28Corneal erosion (HP:0200020)3.76488642
29Palmoplantar keratoderma (HP:0000982)3.65807506
30Nail dystrophy (HP:0008404)3.53421351
31Hyporeflexia of lower limbs (HP:0002600)3.45467445
32Curly hair (HP:0002212)3.42765301
33Abnormal hair laboratory examination (HP:0003328)3.27995457
34Oral leukoplakia (HP:0002745)3.27265073
35Hypergammaglobulinemia (HP:0010702)3.17465974
36Increased connective tissue (HP:0009025)3.14647273
37Type 1 muscle fiber predominance (HP:0003803)3.14130324
38Short nail (HP:0001799)3.07060234
39Hypohidrosis (HP:0000966)2.97217912
40Fragile skin (HP:0001030)2.93751113
41Pruritus (HP:0000989)2.85991200
42Neonatal death (HP:0003811)2.82176713
43Lack of skin elasticity (HP:0100679)2.78428524
44Absent eyelashes (HP:0000561)2.78333756
45Advanced eruption of teeth (HP:0006288)2.76423616
46Broad face (HP:0000283)2.74510582
47Neonatal short-limb short stature (HP:0008921)2.64438445
48Sparse eyelashes (HP:0000653)2.56194395
49Urethral obstruction (HP:0000796)2.55712664
50Ventricular tachycardia (HP:0004756)2.51579128
51Absent hair (HP:0002298)2.51317311
52Sensory axonal neuropathy (HP:0003390)2.50259728
53Aortic aneurysm (HP:0004942)2.48175372
54Natal tooth (HP:0000695)2.47797741
55Lip pit (HP:0100267)2.34432799
56Potter facies (HP:0002009)2.30685126
57Facial shape deformation (HP:0011334)2.30685126
58Parakeratosis (HP:0001036)2.30638259
59Hamartoma (HP:0010566)2.30518180
60Blue irides (HP:0000635)2.29604423
61Renovascular hypertension (HP:0100817)2.22856149
62Ridged nail (HP:0001807)2.20068832
63Premature rupture of membranes (HP:0001788)2.18627867
64Melanocytic nevus (HP:0000995)2.15545399
65Thyroid-stimulating hormone excess (HP:0002925)2.14861207
66Papilloma (HP:0012740)2.13309979
67Verrucae (HP:0200043)2.13309979
68Abnormality of the salivary glands (HP:0010286)2.05241765
69Selective tooth agenesis (HP:0001592)2.05084768
70Hyperhidrosis (HP:0000975)2.04804953
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04080565
72Laryngomalacia (HP:0001601)2.03443283
73Portal hypertension (HP:0001409)2.03281438
74Enlarged kidneys (HP:0000105)2.02104951
75Increased IgE level (HP:0003212)10.8293252
76Hyperkalemia (HP:0002153)1.98429643
77Bladder diverticulum (HP:0000015)1.97798323
78Craniofacial hyperostosis (HP:0004493)1.96686015
79Tubulointerstitial nephritis (HP:0001970)1.93794532
80Ankle contracture (HP:0006466)1.93763428
81Areflexia of lower limbs (HP:0002522)1.93065373
82Furrowed tongue (HP:0000221)1.92550214
83Abnormality of the dental pulp (HP:0006479)1.92255909
84Hypoplastic labia majora (HP:0000059)1.92096320
85Anonychia (HP:0001798)1.89135889
86Abnormality of the neuromuscular junction (HP:0003398)1.89028855
87Fatigable weakness (HP:0003473)1.89028855
88Generalized hypopigmentation of hair (HP:0011358)1.87260567
89Abnormality of the gastric mucosa (HP:0004295)1.87118799
90Esophageal varix (HP:0002040)1.86271988
91Distal lower limb muscle weakness (HP:0009053)1.84984289
92Abnormality of the labia majora (HP:0012881)1.84929166
93Round ear (HP:0100830)1.84878091
94Abnormality of placental membranes (HP:0011409)1.84638388
95Amniotic constriction ring (HP:0009775)1.84638388
96Protrusio acetabuli (HP:0003179)1.84528860
97Blepharitis (HP:0000498)1.84355661
98Osteolytic defects of the hand bones (HP:0009699)1.81052475
99Osteolytic defects of the phalanges of the hand (HP:0009771)1.81052475
100Slender build (HP:0001533)1.80946313
101Abnormality of dentin (HP:0010299)1.80288309
102Abnormality of the hepatic vasculature (HP:0006707)1.80288163
103Oligodontia (HP:0000677)1.80204868
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.80110620
105Skin ulcer (HP:0200042)1.80099514
106Bilateral sensorineural hearing impairment (HP:0008619)1.78417390
107Tibial bowing (HP:0002982)1.76500869
108Tubulointerstitial abnormality (HP:0001969)1.75480507
109Fair hair (HP:0002286)1.74903077
110Hypoplastic toenails (HP:0001800)1.74608908
111Cerebral aneurysm (HP:0004944)1.74589196
112Malignant hyperthermia (HP:0002047)1.73696869
113Duplicated collecting system (HP:0000081)1.72414198
114Ventricular fibrillation (HP:0001663)1.71705341
115Mildly elevated creatine phosphokinase (HP:0008180)1.70571326
116Muscle fiber splitting (HP:0003555)1.69613334
117Abnormality of molar (HP:0011077)1.69291558
118Abnormality of molar morphology (HP:0011070)1.69291558
119Tubulointerstitial fibrosis (HP:0005576)1.69046707
120Spinal rigidity (HP:0003306)1.65971958
121Abnormality of permanent molar morphology (HP:0011071)1.65310033
122Abnormality of the dental root (HP:0006486)1.65310033
123Taurodontia (HP:0000679)1.65310033
124Soft skin (HP:0000977)1.64517431
125Acanthosis nigricans (HP:0000956)1.64188896
126Cranial hyperostosis (HP:0004437)1.63844290
127Abnormality of the nasal septum (HP:0000419)1.62053918
128Increased variability in muscle fiber diameter (HP:0003557)1.61692957
129Corneal dystrophy (HP:0001131)1.61501379
130Depressed nasal tip (HP:0000437)1.59904142
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.59677368
132Spondylolisthesis (HP:0003302)1.59660193
133Overgrowth (HP:0001548)1.58852686
134Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.58648905
135Abnormality of the fingertips (HP:0001211)1.57927803
136Hypoplasia of dental enamel (HP:0006297)1.57703648
137Muscle fiber inclusion bodies (HP:0100299)1.56765969
138Mitral valve prolapse (HP:0001634)1.56314811
139Abnormality of the fingernails (HP:0001231)1.55397902
140Hyperacusis (HP:0010780)1.55258008
141Nemaline bodies (HP:0003798)1.54767007
142Asthma (HP:0002099)1.54381266
143Flat cornea (HP:0007720)1.54141037
144Dilatation of the ascending aorta (HP:0005111)1.53179618
145Dehydration (HP:0001944)1.50373013
146Abnormality of skeletal muscle fiber size (HP:0012084)1.49989561
147Sparse scalp hair (HP:0002209)1.49195103
148Overriding aorta (HP:0002623)1.49012935
149Broad metatarsal (HP:0001783)1.48657418
150Carious teeth (HP:0000670)1.47120106
151Distal lower limb amyotrophy (HP:0008944)1.46671998
152Toxemia of pregnancy (HP:0100603)1.44615489
153Achilles tendon contracture (HP:0001771)1.44614644
154Aortic dissection (HP:0002647)1.42934679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR15.15030604
2FER4.10231085
3MST1R3.79638979
4MAP3K93.70853484
5FRK3.63458813
6MAPKAPK33.36375233
7CDK123.32299795
8LATS12.92205171
9TTN2.83526195
10MAP3K32.80091414
11CAMK1G2.69957012
12MAP3K22.43942002
13ERN12.41936790
14TIE12.41814979
15TGFBR12.40046662
16PIK3CG2.24622370
17TAOK12.23565729
18RIPK12.14631452
19AKT32.08728605
20WNK12.08571622
21FGFR22.05965825
22TRIB31.90659531
23WNK41.89095209
24OBSCN1.84567714
25EPHA31.83616760
26MAP3K111.61113335
27EPHA21.56945370
28NTRK21.52801067
29MET1.47559618
30EPHB11.46932570
31PNCK1.44664842
32SGK21.37709342
33MAP3K71.35317798
34MYLK1.34816303
35EPHB21.33292731
36RPS6KB21.32985184
37FGFR41.30794698
38PDGFRA1.27560989
39LATS21.25246822
40BCR1.24451258
41TYK21.23358501
42MAP2K31.19830941
43WNK31.18266450
44DDR21.17944705
45FGFR31.16582591
46NLK1.16563705
47PDGFRB1.14703483
48SGK31.14441128
49PAK21.09649792
50MAP2K61.07726709
51PRKAA21.06937591
52CDC42BPA1.06384698
53PTK61.05544057
54MAP2K41.03190199
55BRD41.01238319
56OXSR10.99898442
57TGFBR20.99717868
58STK390.99623036
59MAP3K10.98598910
60SGK4940.96817821
61SGK2230.96817821
62EEF2K0.95355393
63TRPM70.94466110
64DAPK20.93672552
65MAPKAPK20.92399984
66STK38L0.91537436
67LMTK20.90865433
68SIK10.90424238
69MST40.89605825
70FGR0.83441828
71NTRK10.81681646
72TYRO30.78539722
73LRRK20.78482710
74MAP3K60.77884059
75CDK60.76644642
76PDK40.75628123
77PDK30.75628123
78MARK20.71669045
79INSRR0.69808314
80PTK20.67992644
81MAPKAPK50.66948204
82IRAK10.64863623
83NEK90.64170383
84STK30.63775685
85MELK0.62721116
86YES10.61636257
87PRKD30.61333855
88BMX0.61275947
89NME10.60929414
90PRKCH0.60921769
91RPS6KA20.60493384
92PHKG20.59431249
93PHKG10.59431249
94HCK0.57604224
95BMPR1B0.54581500
96ACVR1B0.54263762
97PKN20.54222600
98CHUK0.53402007
99PIK3CA0.53245038
100JAK10.51115908
101PRKD10.50970449
102MAPK110.50803053
103MAP3K130.50717475
104PRKAA10.50433849
105DMPK0.48855376
106PRKD20.47976382
107MAP2K10.45721365
108SCYL20.44429272
109DYRK1B0.44193371
110MTOR0.43841094
111MAPK10.43115705
112STK240.42832652
113HIPK20.42544933
114PAK30.42524577
115RPS6KA40.42387844
116NEK60.41635307
117KIT0.41245866
118PRKCE0.40985702
119BLK0.40312493
120GSK3A0.40278764
121RET0.39832110
122ICK0.39395159
123STK110.38895342
124ITK0.38370399
125PKN10.37147164
126PDK20.36374154
127MAPK100.35338281
128MAPK70.34162319
129CSNK1A1L0.34067112
130PRKCI0.33347267
131STK380.33231580
132MAPK120.32776519
133FYN0.32028780
134ERBB30.31021799
135ERBB20.30850412
136EGFR0.29520392
137ATM0.29070631
138SRC0.27144412
139CAMK1D0.24725871
140JAK20.24304770
141CSNK1D0.23857088
142RPS6KA10.22964916
143GRK10.22167372
144STK100.22152743
145ROCK10.21991209
146ERBB40.21364611
147SGK10.21267189
148KSR20.17913475

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.37141010
2Linoleic acid metabolism_Homo sapiens_hsa005913.27678555
3Fatty acid elongation_Homo sapiens_hsa000623.24105480
4ECM-receptor interaction_Homo sapiens_hsa045122.37375770
5Arachidonic acid metabolism_Homo sapiens_hsa005902.21118187
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.03975590
7Ether lipid metabolism_Homo sapiens_hsa005651.97376556
8Steroid biosynthesis_Homo sapiens_hsa001001.97276330
9Staphylococcus aureus infection_Homo sapiens_hsa051501.92394122
10ABC transporters_Homo sapiens_hsa020101.91529531
11Sphingolipid metabolism_Homo sapiens_hsa006001.90453369
12Protein digestion and absorption_Homo sapiens_hsa049741.85418718
13GnRH signaling pathway_Homo sapiens_hsa049121.77892176
14Fat digestion and absorption_Homo sapiens_hsa049751.64349468
15Phenylalanine metabolism_Homo sapiens_hsa003601.59503239
16Dorso-ventral axis formation_Homo sapiens_hsa043201.54791438
17VEGF signaling pathway_Homo sapiens_hsa043701.54468656
18Gastric acid secretion_Homo sapiens_hsa049711.53511676
19Phototransduction_Homo sapiens_hsa047441.43755985
20Adherens junction_Homo sapiens_hsa045201.40598931
21Amoebiasis_Homo sapiens_hsa051461.39575338
22Thyroid cancer_Homo sapiens_hsa052161.36579211
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36361344
24Lysine degradation_Homo sapiens_hsa003101.36293555
25Histidine metabolism_Homo sapiens_hsa003401.33987581
26Proteoglycans in cancer_Homo sapiens_hsa052051.31787542
27Renin secretion_Homo sapiens_hsa049241.31648175
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31215660
29Basal cell carcinoma_Homo sapiens_hsa052171.28034581
30Tight junction_Homo sapiens_hsa045301.27612398
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.22740381
32Thyroid hormone synthesis_Homo sapiens_hsa049181.22482937
33Focal adhesion_Homo sapiens_hsa045101.17305672
34Axon guidance_Homo sapiens_hsa043601.17029071
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.15897285
36Melanogenesis_Homo sapiens_hsa049161.15323943
37Glioma_Homo sapiens_hsa052141.14046938
38Circadian rhythm_Homo sapiens_hsa047101.13314143
39Inositol phosphate metabolism_Homo sapiens_hsa005621.10615281
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09905006
41Long-term depression_Homo sapiens_hsa047301.08241070
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05735815
43Platelet activation_Homo sapiens_hsa046111.04764569
44Long-term potentiation_Homo sapiens_hsa047201.00900816
45Fatty acid biosynthesis_Homo sapiens_hsa000610.98879543
46Hippo signaling pathway_Homo sapiens_hsa043900.95716747
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94620295
48Estrogen signaling pathway_Homo sapiens_hsa049150.92290800
49ErbB signaling pathway_Homo sapiens_hsa040120.92017011
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.90939060
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89627785
52Salivary secretion_Homo sapiens_hsa049700.89624940
53MicroRNAs in cancer_Homo sapiens_hsa052060.89469279
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87327886
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.85600655
56Ras signaling pathway_Homo sapiens_hsa040140.85301528
57Pertussis_Homo sapiens_hsa051330.84913685
58Glutamatergic synapse_Homo sapiens_hsa047240.83997427
59Oxytocin signaling pathway_Homo sapiens_hsa049210.83943996
60Toxoplasmosis_Homo sapiens_hsa051450.83657927
61Tyrosine metabolism_Homo sapiens_hsa003500.82870894
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82471045
63PPAR signaling pathway_Homo sapiens_hsa033200.81309200
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79796033
65Acute myeloid leukemia_Homo sapiens_hsa052210.79286396
66Rap1 signaling pathway_Homo sapiens_hsa040150.77295267
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.76232639
68Pancreatic secretion_Homo sapiens_hsa049720.75116205
69Retinol metabolism_Homo sapiens_hsa008300.73922670
70Insulin resistance_Homo sapiens_hsa049310.73752192
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73301168
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71798983
73Bile secretion_Homo sapiens_hsa049760.71336524
74Prostate cancer_Homo sapiens_hsa052150.70526845
75Serotonergic synapse_Homo sapiens_hsa047260.70157455
76Complement and coagulation cascades_Homo sapiens_hsa046100.69653841
77Bladder cancer_Homo sapiens_hsa052190.68572329
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67715502
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66967447
80Gap junction_Homo sapiens_hsa045400.66419867
81Olfactory transduction_Homo sapiens_hsa047400.65733218
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64529062
83Taste transduction_Homo sapiens_hsa047420.63970900
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.63304368
85cAMP signaling pathway_Homo sapiens_hsa040240.63045531
86Insulin secretion_Homo sapiens_hsa049110.62841682
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.62434007
88Hedgehog signaling pathway_Homo sapiens_hsa043400.61284675
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59974799
90Dilated cardiomyopathy_Homo sapiens_hsa054140.59677826
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59484963
92Notch signaling pathway_Homo sapiens_hsa043300.58549861
93Insulin signaling pathway_Homo sapiens_hsa049100.58381735
94TGF-beta signaling pathway_Homo sapiens_hsa043500.58143025
95Oocyte meiosis_Homo sapiens_hsa041140.57145410
96Caffeine metabolism_Homo sapiens_hsa002320.56911921
97Glucagon signaling pathway_Homo sapiens_hsa049220.55603615
98Endocytosis_Homo sapiens_hsa041440.54631514
99Ovarian steroidogenesis_Homo sapiens_hsa049130.54308925
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52844102
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52733148
102Calcium signaling pathway_Homo sapiens_hsa040200.50997008
103Small cell lung cancer_Homo sapiens_hsa052220.50677283
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49733929
105Pancreatic cancer_Homo sapiens_hsa052120.47644425
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46996666
107Wnt signaling pathway_Homo sapiens_hsa043100.46981357
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46705967
109Renal cell carcinoma_Homo sapiens_hsa052110.46666117
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46505453
111Tuberculosis_Homo sapiens_hsa051520.46416290
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.45772864
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45529318
114Hepatitis C_Homo sapiens_hsa051600.45154581
115MAPK signaling pathway_Homo sapiens_hsa040100.44668810
116Choline metabolism in cancer_Homo sapiens_hsa052310.44528696
117mTOR signaling pathway_Homo sapiens_hsa041500.44371136
118Type II diabetes mellitus_Homo sapiens_hsa049300.43991315
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43709787
120Melanoma_Homo sapiens_hsa052180.43390712
121Fatty acid degradation_Homo sapiens_hsa000710.42988758
122Chronic myeloid leukemia_Homo sapiens_hsa052200.42769970
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42668386
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.42437630
125Vibrio cholerae infection_Homo sapiens_hsa051100.42346798
126Circadian entrainment_Homo sapiens_hsa047130.41795028
127Non-small cell lung cancer_Homo sapiens_hsa052230.41312512
128Pathways in cancer_Homo sapiens_hsa052000.41081154
129Endometrial cancer_Homo sapiens_hsa052130.41015432
130Fatty acid metabolism_Homo sapiens_hsa012120.36951153
131Malaria_Homo sapiens_hsa051440.35135215

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