HS1BP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)4.67610828
2regulation of gene silencing by miRNA (GO:0060964)4.67610828
3regulation of gene silencing by RNA (GO:0060966)4.67610828
4folic acid-containing compound biosynthetic process (GO:0009396)4.21792023
5formation of translation preinitiation complex (GO:0001731)4.15330017
6positive regulation of SMAD protein import into nucleus (GO:0060391)4.06900676
7response to peptidoglycan (GO:0032494)4.06307037
8regulation of SMAD protein import into nucleus (GO:0060390)4.00516611
9IMP biosynthetic process (GO:0006188)3.65062456
10paraxial mesoderm development (GO:0048339)3.56120501
11protein localization to endosome (GO:0036010)3.52833910
12pinocytosis (GO:0006907)3.52650192
13detection of molecule of bacterial origin (GO:0032490)3.50398914
14barbed-end actin filament capping (GO:0051016)3.48350124
15basement membrane organization (GO:0071711)3.46097080
16macrophage activation involved in immune response (GO:0002281)3.40340184
17glycosphingolipid catabolic process (GO:0046479)3.38464335
18regulation of hippo signaling (GO:0035330)3.37425104
19negative regulation of erythrocyte differentiation (GO:0045647)3.36994579
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35093897
21detection of other organism (GO:0098543)3.31316555
22negative regulation of interleukin-12 production (GO:0032695)3.28243057
23pteridine-containing compound biosynthetic process (GO:0042559)3.18771529
24detection of external biotic stimulus (GO:0098581)3.17796976
25IMP metabolic process (GO:0046040)3.17081036
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16892015
27mannose metabolic process (GO:0006013)3.14266988
28regulation of mast cell degranulation (GO:0043304)3.12795978
29regulation of translational fidelity (GO:0006450)3.11851412
30detection of bacterium (GO:0016045)3.11084024
31fat-soluble vitamin biosynthetic process (GO:0042362)3.08809595
32nucleobase biosynthetic process (GO:0046112)3.08355206
33regulation of leukocyte degranulation (GO:0043300)3.05926693
34amino sugar catabolic process (GO:0046348)3.04989213
35maturation of SSU-rRNA (GO:0030490)3.03111145
36regulation of early endosome to late endosome transport (GO:2000641)3.02554701
37glycolipid catabolic process (GO:0019377)3.02319957
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01501777
39negative regulation of cell killing (GO:0031342)3.01501777
40positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00342014
41nodal signaling pathway (GO:0038092)2.99174159
42heterochromatin organization (GO:0070828)2.98237264
43regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95840962
44oligosaccharide catabolic process (GO:0009313)2.94995590
45embryonic process involved in female pregnancy (GO:0060136)2.94884653
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89266968
47outer ear morphogenesis (GO:0042473)2.89248885
48positive regulation of extracellular matrix organization (GO:1903055)2.85839651
49NADPH regeneration (GO:0006740)2.85403917
50immunoglobulin mediated immune response (GO:0016064)2.84928488
51cellular response to thyroid hormone stimulus (GO:0097067)2.84008216
52antigen processing and presentation of endogenous antigen (GO:0019883)2.83588664
53regulation of helicase activity (GO:0051095)2.81722781
54positive regulation of Cdc42 GTPase activity (GO:0043089)2.80002971
55regulation of interferon-beta biosynthetic process (GO:0045357)2.78321269
56purine nucleobase biosynthetic process (GO:0009113)2.77186679
57detection of biotic stimulus (GO:0009595)2.77158366
58regulation of superoxide anion generation (GO:0032928)2.76785526
59tetrahydrofolate metabolic process (GO:0046653)2.76050457
60regulation of mast cell activation involved in immune response (GO:0033006)2.75229476
61regulation of T-helper 2 cell differentiation (GO:0045628)2.75228776
62stress fiber assembly (GO:0043149)2.72771715
63intestinal epithelial cell development (GO:0060576)2.71542573
64response to thyroid hormone (GO:0097066)2.71460012
65amyloid precursor protein catabolic process (GO:0042987)2.69949007
66NIK/NF-kappaB signaling (GO:0038061)2.69853993
67DNA unwinding involved in DNA replication (GO:0006268)2.69052514
68pentose-phosphate shunt (GO:0006098)2.68806481
69response to muramyl dipeptide (GO:0032495)2.68097566
70positive regulation of cellular amide metabolic process (GO:0034250)2.67812702
71response to laminar fluid shear stress (GO:0034616)2.67055168
72positive regulation of gamma-delta T cell activation (GO:0046645)2.66830435
73N-acetylneuraminate metabolic process (GO:0006054)2.66350282
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66160412
75response to host (GO:0075136)2.66160412
76response to host defenses (GO:0052200)2.66160412
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.65551988
78positive regulation of leukocyte degranulation (GO:0043302)2.65544342
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65261511
80apoptotic process involved in morphogenesis (GO:0060561)2.63789561
81endosome to melanosome transport (GO:0035646)2.62646770
82endosome to pigment granule transport (GO:0043485)2.62646770
83positive regulation of receptor recycling (GO:0001921)2.62186703
84DNA strand elongation involved in DNA replication (GO:0006271)2.61292534
85anterior/posterior axis specification, embryo (GO:0008595)2.59872498
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59448848
87response to host immune response (GO:0052572)2.59448848
88granulocyte activation (GO:0036230)2.58202141
89modulation by symbiont of host cellular process (GO:0044068)2.58180572
90glycine metabolic process (GO:0006544)2.57291497
91histone H2A monoubiquitination (GO:0035518)2.53771673
92positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53546327
93hyaluronan catabolic process (GO:0030214)2.52852265
94negative regulation of androgen receptor signaling pathway (GO:0060766)2.52198398
95positive regulation of protein homooligomerization (GO:0032464)2.51628219
96ceramide catabolic process (GO:0046514)2.50164888
97regulation of extracellular matrix disassembly (GO:0010715)2.49751703
98alpha-linolenic acid metabolic process (GO:0036109)2.46647596
99DNA strand elongation (GO:0022616)2.45301484
100epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45040025
101positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.44532403
102apoptotic cell clearance (GO:0043277)2.44495051
103proline biosynthetic process (GO:0006561)2.44159631
104regulation of chemokine secretion (GO:0090196)2.43981458
105DNA replication initiation (GO:0006270)2.43295049
106macrophage activation (GO:0042116)2.43059734
107metanephric mesenchyme development (GO:0072075)2.42609368
108female genitalia development (GO:0030540)2.41571275
109kidney mesenchyme development (GO:0072074)2.41426956
110positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.40775189
111low-density lipoprotein particle clearance (GO:0034383)2.40007058
112establishment of apical/basal cell polarity (GO:0035089)2.39928711
113neutrophil activation involved in immune response (GO:0002283)2.39815470
114nuclear pore organization (GO:0006999)2.39750424
115pre-miRNA processing (GO:0031054)2.38691156
116regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.38160413
117ribosomal small subunit assembly (GO:0000028)2.37615084
118mitotic nuclear envelope disassembly (GO:0007077)2.37075008
119cellular extravasation (GO:0045123)2.36570116
120trophectodermal cell differentiation (GO:0001829)2.36240354
121negative regulation of cytokine production involved in immune response (GO:0002719)2.35865264
122neutrophil activation (GO:0042119)2.35789229
123vagina development (GO:0060068)2.35170529
124peptide catabolic process (GO:0043171)2.34986545
125regulation of regulated secretory pathway (GO:1903305)2.33749520
126regulation of translation in response to stress (GO:0043555)2.33708392
127germinal center formation (GO:0002467)2.33157566
128organ regeneration (GO:0031100)2.33147907
129positive regulation of mast cell activation (GO:0033005)2.32293062
130maternal placenta development (GO:0001893)2.32258256
131COPI coating of Golgi vesicle (GO:0048205)2.32028046
132Golgi transport vesicle coating (GO:0048200)2.32028046
133negative regulation of myeloid cell apoptotic process (GO:0033033)2.31889163
134positive regulation of mast cell activation involved in immune response (GO:0033008)2.31652975
135positive regulation of mast cell degranulation (GO:0043306)2.31652975
136T cell apoptotic process (GO:0070231)2.31493559
137negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31359066
138myeloid dendritic cell differentiation (GO:0043011)2.29600128
139negative regulation of fatty acid biosynthetic process (GO:0045717)2.28148708
140regulation of membrane protein ectodomain proteolysis (GO:0051043)2.28073419
141folic acid metabolic process (GO:0046655)2.27685607
142regulation of gene silencing (GO:0060968)2.27621011
143regulation of cholesterol storage (GO:0010885)2.27291054
144negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.25635355
145embryonic placenta development (GO:0001892)2.24920387
146ribosome biogenesis (GO:0042254)2.24784426
147nucleoside salvage (GO:0043174)2.24048550
148viral transcription (GO:0019083)2.23807472
149translational initiation (GO:0006413)2.23690594
150positive regulation by symbiont of host defense response (GO:0052509)2.23598038
151modulation by symbiont of host defense response (GO:0052031)2.23598038
152modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.23598038
153modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.23598038
154positive regulation by organism of defense response of other organism involved in symbiotic interact2.23598038
155modulation by symbiont of host immune response (GO:0052553)2.23598038
156substrate adhesion-dependent cell spreading (GO:0034446)2.22707520
157cytidine deamination (GO:0009972)2.22618116
158cytidine metabolic process (GO:0046087)2.22618116
159cytidine catabolic process (GO:0006216)2.22618116
160tRNA aminoacylation for protein translation (GO:0006418)2.22250710
161myeloid cell activation involved in immune response (GO:0002275)2.22200531
162positive regulation of chemokine secretion (GO:0090197)2.22098304
163positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.22057310
164fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.22053690
165regulation of extracellular matrix organization (GO:1903053)2.21637095
166positive regulation of type 2 immune response (GO:0002830)2.20974519
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.20010855
168folic acid-containing compound metabolic process (GO:0006760)2.19393630
169cranial suture morphogenesis (GO:0060363)2.19198912
170production of molecular mediator involved in inflammatory response (GO:0002532)2.18786849
171response to UV-C (GO:0010225)2.18609737
172vascular endothelial growth factor signaling pathway (GO:0038084)2.18511369
173pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.18262895
174UMP biosynthetic process (GO:0006222)2.18262895
175pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.18262895
176UMP metabolic process (GO:0046049)2.18262895
177nuclear envelope disassembly (GO:0051081)2.18246402
178membrane disassembly (GO:0030397)2.18246402
179regulation of integrin activation (GO:0033623)2.17845179
180positive regulation of phagocytosis (GO:0050766)2.17826425
181glyoxylate metabolic process (GO:0046487)2.17748337
182amino acid activation (GO:0043038)2.15958786
183tRNA aminoacylation (GO:0043039)2.15958786
184telomere maintenance via semi-conservative replication (GO:0032201)2.14621599
185aspartate family amino acid biosynthetic process (GO:0009067)2.13616796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.19527175
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.62833353
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.08726312
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.98998732
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.98998732
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.98998732
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97622535
8LXR_22292898_ChIP-Seq_THP-1_Human2.62613099
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.62576135
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61645600
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30341126
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24633058
13STAT3_1855785_ChIP-Seq_MESCs_Mouse2.17191346
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12183792
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12113143
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.11122753
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08727167
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04817483
19TFEB_21752829_ChIP-Seq_HELA_Human2.01255220
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00673270
21VDR_24763502_ChIP-Seq_THP-1_Human1.98735200
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98226906
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97811845
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94968904
25TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94678464
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92052938
27* TCF7_22412390_ChIP-Seq_EML_Mouse1.84508815
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79931360
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79565094
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79280251
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.79099039
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78038955
33KDM2B_26808549_Chip-Seq_DND41_Human1.74648673
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74262001
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.73665004
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73135067
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72494822
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69627238
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66718218
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66144967
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61890446
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59583566
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.58504792
44SPI1_23127762_ChIP-Seq_K562_Human1.57233488
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56174610
46MAF_26560356_Chip-Seq_TH1_Human1.55897846
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53396027
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52171966
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.49995884
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49583761
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47689946
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45828916
53KDM2B_26808549_Chip-Seq_K562_Human1.44851185
54* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44386671
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44075147
56XRN2_22483619_ChIP-Seq_HELA_Human1.40957902
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.40949941
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.40831827
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39261579
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37859301
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37767012
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37444291
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.37252244
64CLOCK_20551151_ChIP-Seq_293T_Human1.36846911
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34934087
66MYC_22102868_ChIP-Seq_BL_Human1.33117323
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32854113
68ZNF263_19887448_ChIP-Seq_K562_Human1.32706950
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32481608
70SPI1_23547873_ChIP-Seq_NB4_Human1.32439504
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.31114770
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31058358
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30029680
74UTX_26944678_Chip-Seq_JUKART_Human1.30011532
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29362177
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28659203
77* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28494038
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.28395180
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28096998
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27737906
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27566851
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27096003
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26837111
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25896232
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.25725064
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25575978
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25243495
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25232025
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25202840
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24930134
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24874432
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24128660
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24113815
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23757541
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23633335
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23569786
97MAF_26560356_Chip-Seq_TH2_Human1.23280146
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23177172
99VDR_21846776_ChIP-Seq_THP-1_Human1.21665942
100P68_20966046_ChIP-Seq_HELA_Human1.21480942
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21418994
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20759750
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20464709
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20407854
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20250829
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20015849
107MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19518940
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19359506
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.19355389
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.19001414
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18483014
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17916918
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17915984
114DCP1A_22483619_ChIP-Seq_HELA_Human1.16865309
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16776940
116NCOR1_26117541_ChIP-Seq_K562_Human1.16767903
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15725127
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15665964
119ATF3_27146783_Chip-Seq_COLON_Human1.15537896
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15182277
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14916251
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14576394
123BCOR_27268052_Chip-Seq_Bcells_Human1.14560147
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14107187
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.13647244
126SCL_19346495_ChIP-Seq_HPC-7_Human1.12687744
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12530110
128TP63_17297297_ChIP-ChIP_HaCaT_Human1.11665204
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11589706
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11230636
131GABP_17652178_ChIP-ChIP_JURKAT_Human1.10408314
132BCL6_27268052_Chip-Seq_Bcells_Human1.10043201
133GATA2_21666600_ChIP-Seq_HMVEC_Human1.09516202
134GATA1_19941826_ChIP-Seq_K562_Human1.09392870
135* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08663737
136SMC4_20622854_ChIP-Seq_HELA_Human1.08282636
137RACK7_27058665_Chip-Seq_MCF-7_Human1.08114807
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07328998
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06333232
140PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05419682
141POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05410730
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05188736
143E2F1_21310950_ChIP-Seq_MCF-7_Human1.04770195
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04127211
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03799934
146* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03714116
147NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03064513
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02968228
149NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02662654
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02499445
151TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02258261
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00861736
153GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00681656
154ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00656183
155P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99769647
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99700830
157GABP_19822575_ChIP-Seq_HepG2_Human0.98653513
158TP53_22127205_ChIP-Seq_IMR90_Human0.98370302
159AR_21909140_ChIP-Seq_LNCAP_Human0.98352468
160YY1_21170310_ChIP-Seq_MESCs_Mouse0.98131190
161IRF8_22096565_ChIP-ChIP_GC-B_Human0.97684456
162IRF8_21731497_ChIP-ChIP_J774_Mouse0.96017142
163TTF2_22483619_ChIP-Seq_HELA_Human0.95852521
164SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95778475
165BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94849385
166LXR_22158963_ChIP-Seq_LIVER_Mouse0.94383341

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.49767164
2MP0009840_abnormal_foam_cell3.47531341
3MP0003806_abnormal_nucleotide_metabolis2.94296765
4MP0005058_abnormal_lysosome_morphology2.87195763
5MP0005451_abnormal_body_composition2.76648445
6MP0003705_abnormal_hypodermis_morpholog2.74642047
7MP0003172_abnormal_lysosome_physiology2.52673908
8MP0008260_abnormal_autophagy2.48395203
9MP0003566_abnormal_cell_adhesion2.46877818
10MP0003724_increased_susceptibility_to2.46531182
11MP0008438_abnormal_cutaneous_collagen2.28376979
12MP0002419_abnormal_innate_immunity2.19189967
13MP0010352_gastrointestinal_tract_polyps2.18678542
14MP0003567_abnormal_fetal_cardiomyocyte2.08173887
15MP0005464_abnormal_platelet_physiology2.05295230
16MP0003191_abnormal_cellular_cholesterol1.93133204
17MP0004957_abnormal_blastocyst_morpholog1.89609285
18MP0005025_abnormal_response_to1.87333446
19MP0001533_abnormal_skeleton_physiology1.84842221
20MP0000685_abnormal_immune_system1.84244225
21MP0002148_abnormal_hypersensitivity_rea1.79392334
22MP0001835_abnormal_antigen_presentation1.78536627
23MP0005023_abnormal_wound_healing1.75484752
24MP0009785_altered_susceptibility_to1.74947392
25MP0005670_abnormal_white_adipose1.71271853
26MP0003453_abnormal_keratinocyte_physiol1.68239620
27MP0003075_altered_response_to1.67070803
28MP0004510_myositis1.66672094
29MP0005000_abnormal_immune_tolerance1.65699912
30MP0000604_amyloidosis1.64709951
31MP0010030_abnormal_orbit_morphology1.61585101
32MP0002998_abnormal_bone_remodeling1.61072236
33MP0003941_abnormal_skin_development1.59608827
34MP0005387_immune_system_phenotype1.58654447
35MP0001790_abnormal_immune_system1.58654447
36MP0010307_abnormal_tumor_latency1.57725094
37MP0004947_skin_inflammation1.56679214
38MP0002877_abnormal_melanocyte_morpholog1.56149855
39MP0002163_abnormal_gland_morphology1.53976672
40MP0004133_heterotaxia1.53042192
41MP0003693_abnormal_embryo_hatching1.51054610
42MP0004858_abnormal_nervous_system1.50784551
43MP0004272_abnormal_basement_membrane1.44388846
44MP0003111_abnormal_nucleus_morphology1.41762961
45MP0000371_diluted_coat_color1.41438023
46MP0002452_abnormal_antigen_presenting1.41353190
47MP0003828_pulmonary_edema1.38652402
48MP0002723_abnormal_immune_serum1.36815418
49MP0001730_embryonic_growth_arrest1.36697384
50MP0008007_abnormal_cellular_replicative1.35494314
51MP0004084_abnormal_cardiac_muscle1.32624095
52MP0005076_abnormal_cell_differentiation1.31409833
53MP0003183_abnormal_peptide_metabolism1.31208247
54MP0003077_abnormal_cell_cycle1.31039247
55MP0008057_abnormal_DNA_replication1.30924267
56MP0002086_abnormal_extraembryonic_tissu1.27429112
57MP0003186_abnormal_redox_activity1.26771093
58MP0009333_abnormal_splenocyte_physiolog1.25668547
59MP0008469_abnormal_protein_level1.25560659
60MP0001819_abnormal_immune_cell1.25218480
61MP0002420_abnormal_adaptive_immunity1.25157372
62MP0009278_abnormal_bone_marrow1.25056748
63MP0009053_abnormal_anal_canal1.23900723
64MP0001845_abnormal_inflammatory_respons1.22858530
65MP0006138_congestive_heart_failure1.22020615
66MP0001915_intracranial_hemorrhage1.22008278
67MP0002132_abnormal_respiratory_system1.21790900
68MP0001800_abnormal_humoral_immune1.20978236
69MP0005409_darkened_coat_color1.20347846
70MP0010155_abnormal_intestine_physiology1.19776219
71MP0003300_gastrointestinal_ulcer1.19700040
72MP0003329_amyloid_beta_deposits1.18964888
73MP0002405_respiratory_system_inflammati1.15984189
74MP0005365_abnormal_bile_salt1.15902632
75MP0004197_abnormal_fetal_growth/weight/1.15445690
76MP0005257_abnormal_intraocular_pressure1.15158403
77MP0006054_spinal_hemorrhage1.11875478
78MP0003448_altered_tumor_morphology1.11367147
79MP0005380_embryogenesis_phenotype1.11127081
80MP0001672_abnormal_embryogenesis/_devel1.11127081
81MP0008004_abnormal_stomach_pH1.09775473
82MP0001697_abnormal_embryo_size1.09620476
83MP0002089_abnormal_postnatal_growth/wei1.08807814
84MP0000733_abnormal_muscle_development1.08735327
85MP0000350_abnormal_cell_proliferation1.08039823
86MP0003984_embryonic_growth_retardation1.07827354
87MP0000858_altered_metastatic_potential1.07728309
88MP0002088_abnormal_embryonic_growth/wei1.07175328
89MP0005623_abnormal_meninges_morphology1.06136161
90MP0010630_abnormal_cardiac_muscle1.05731176
91MP0009764_decreased_sensitivity_to1.05045380
92MP0000465_gastrointestinal_hemorrhage1.04953124
93MP0005671_abnormal_response_to1.04124143
94MP0003690_abnormal_glial_cell1.03735851
95MP0005164_abnormal_response_to1.02216854
96MP0000343_altered_response_to1.01742751
97MP0003279_aneurysm1.01327516
98MP0002080_prenatal_lethality1.00425057
99MP0008058_abnormal_DNA_repair1.00073542
100MP0000598_abnormal_liver_morphology0.99763973
101MP0002277_abnormal_respiratory_mucosa0.98259899
102MP0005360_urolithiasis0.96990859
103MP0003656_abnormal_erythrocyte_physiolo0.94763633
104MP0005166_decreased_susceptibility_to0.94031932
105MP0005390_skeleton_phenotype0.93754387
106MP0002269_muscular_atrophy0.93353044
107MP0010094_abnormal_chromosome_stability0.92694949
108MP0001851_eye_inflammation0.90734381
109MP0002085_abnormal_embryonic_tissue0.89578685
110MP0002925_abnormal_cardiovascular_devel0.89576232
111MP0006082_CNS_inflammation0.87947274
112MP0000767_abnormal_smooth_muscle0.87671587
113MP0000716_abnormal_immune_system0.87573016
114MP0002139_abnormal_hepatobiliary_system0.87301020
115MP0005367_renal/urinary_system_phenotyp0.87056447
116MP0000516_abnormal_urinary_system0.87056447
117MP0004233_abnormal_muscle_weight0.86842062
118MP0001175_abnormal_lung_morphology0.86441044
119MP0002295_abnormal_pulmonary_circulatio0.85560118
120MP0003283_abnormal_digestive_organ0.85281164
121MP0001958_emphysema0.83832920
122MP0001544_abnormal_cardiovascular_syste0.83561425
123MP0005385_cardiovascular_system_phenoty0.83561425
124MP0005310_abnormal_salivary_gland0.83557112
125MP0004381_abnormal_hair_follicle0.83290829
126MP0005408_hypopigmentation0.82795180
127MP0003436_decreased_susceptibility_to0.82665249
128MP0000609_abnormal_liver_physiology0.81915302
129MP0004883_abnormal_blood_vessel0.81867746
130MP0002084_abnormal_developmental_patter0.81820678
131MP0000015_abnormal_ear_pigmentation0.81392656
132MP0008932_abnormal_embryonic_tissue0.81339839
133MP0001853_heart_inflammation0.81278406
134MP0001849_ear_inflammation0.81109216
135MP0005085_abnormal_gallbladder_physiolo0.80933865
136MP0002128_abnormal_blood_circulation0.80818042
137MP0003795_abnormal_bone_structure0.79841599
138MP0002135_abnormal_kidney_morphology0.79520341
139MP0005319_abnormal_enzyme/_coenzyme0.78623812
140MP0002254_reproductive_system_inflammat0.77744581
141MP0009643_abnormal_urine_homeostasis0.77334220
142MP0003091_abnormal_cell_migration0.76704393
143MP0005165_increased_susceptibility_to0.76368844
144MP0000249_abnormal_blood_vessel0.76260818
145MP0000920_abnormal_myelination0.75959897
146MP0002429_abnormal_blood_cell0.75807683
147MP0005379_endocrine/exocrine_gland_phen0.75597268
148MP0002933_joint_inflammation0.75551136
149MP0002398_abnormal_bone_marrow0.75512401
150MP0000428_abnormal_craniofacial_morphol0.74648202
151MP0001614_abnormal_blood_vessel0.74646379
152MP0005397_hematopoietic_system_phenotyp0.74158574
153MP0001545_abnormal_hematopoietic_system0.74158574
154MP0000313_abnormal_cell_death0.73588163
155MP0005266_abnormal_metabolism0.71817842
156MP0003878_abnormal_ear_physiology0.71817583
157MP0005377_hearing/vestibular/ear_phenot0.71817583
158MP0010234_abnormal_vibrissa_follicle0.71218009
159MP0003890_abnormal_embryonic-extraembry0.71197433
160MP0008874_decreased_physiological_sensi0.70872988
161MP0001348_abnormal_lacrimal_gland0.70336394
162MP0009763_increased_sensitivity_to0.70160493
163MP0005197_abnormal_uvea_morphology0.68538094
164MP0003123_paternal_imprinting0.68501225
165MP0000613_abnormal_salivary_gland0.67813292

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)4.82260369
2Eczematoid dermatitis (HP:0000976)3.89135953
3Protrusio acetabuli (HP:0003179)3.71592982
4Ileus (HP:0002595)3.50665709
5Axonal loss (HP:0003447)3.45832965
6Agnosia (HP:0010524)3.34540259
7Loss of speech (HP:0002371)3.32820942
8Multiple enchondromatosis (HP:0005701)3.28239418
9Cervical subluxation (HP:0003308)3.19761647
10Systemic lupus erythematosus (HP:0002725)3.10453284
11Purpura (HP:0000979)3.01832037
12Vacuolated lymphocytes (HP:0001922)2.95732244
13Morphological abnormality of the inner ear (HP:0011390)2.90813989
14Rectal prolapse (HP:0002035)2.80185893
15Deep venous thrombosis (HP:0002625)2.76525441
16Vertebral compression fractures (HP:0002953)2.72565072
17Esophageal varix (HP:0002040)2.71681050
18Increased cerebral lipofuscin (HP:0011813)2.68625135
19Urinary glycosaminoglycan excretion (HP:0003541)2.67011059
20Mucopolysacchariduria (HP:0008155)2.67011059
21Amyloidosis (HP:0011034)2.63402097
22Abnormality of macrophages (HP:0004311)2.60592835
23Nuclear cataract (HP:0100018)2.59268366
24Myositis (HP:0100614)2.58966723
25Myocardial infarction (HP:0001658)2.58616139
26Orchitis (HP:0100796)2.55930687
27Ependymoma (HP:0002888)2.53301486
28Dysostosis multiplex (HP:0000943)2.49996404
29Hemorrhage of the eye (HP:0011885)2.48475978
30Abnormality of polysaccharide metabolism (HP:0011012)2.45004376
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45004376
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45004376
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.41523102
34Chronic obstructive pulmonary disease (HP:0006510)2.38568285
35Obstructive lung disease (HP:0006536)2.38568285
36Gingivitis (HP:0000230)2.35940066
37Hand muscle atrophy (HP:0009130)2.34308084
38Neurofibrillary tangles (HP:0002185)2.28577122
39Spontaneous hematomas (HP:0007420)2.28450526
40Mediastinal lymphadenopathy (HP:0100721)2.27664216
41Personality changes (HP:0000751)2.27498913
42Cerebral aneurysm (HP:0004944)2.26534504
43Asymmetric septal hypertrophy (HP:0001670)2.25287119
44Premature rupture of membranes (HP:0001788)2.24785360
45Distal upper limb amyotrophy (HP:0007149)2.24642295
46Upper limb amyotrophy (HP:0009129)2.24642295
47Petechiae (HP:0000967)2.23822679
48Interstitial pulmonary disease (HP:0006530)2.18839459
49Distal lower limb muscle weakness (HP:0009053)2.18278751
50Hematochezia (HP:0002573)2.18231602
51Ankle contracture (HP:0006466)2.16389902
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14671224
53Polycythemia (HP:0001901)2.10722934
54Progressive neurologic deterioration (HP:0002344)2.10509141
55Cellulitis (HP:0100658)2.10080092
56Hepatosplenomegaly (HP:0001433)2.08452503
57Spinal muscular atrophy (HP:0007269)2.08436296
58Spastic diplegia (HP:0001264)2.07024891
59Gingival bleeding (HP:0000225)2.06169009
60Selective tooth agenesis (HP:0001592)2.04400841
61Abnormality of liposaccharide metabolism (HP:0010968)2.04265037
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.04265037
63Abnormality of glycolipid metabolism (HP:0010969)2.04265037
64Achilles tendon contracture (HP:0001771)2.03643044
65Abnormality of the Achilles tendon (HP:0005109)2.03455742
66Abnormality of the distal phalanges of the toes (HP:0010182)2.03144063
67Cerebral inclusion bodies (HP:0100314)2.01426165
68Male infertility (HP:0003251)1.99702036
69Mesangial abnormality (HP:0001966)1.99230194
70Epistaxis (HP:0000421)1.98777514
71Increased connective tissue (HP:0009025)1.97895997
72Optic neuritis (HP:0100653)1.97329303
73Retrobulbar optic neuritis (HP:0100654)1.97329303
74Vaginal fistula (HP:0004320)1.97187498
75Thin bony cortex (HP:0002753)1.96895794
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96144500
77Increased serum ferritin (HP:0003281)1.94886102
78Hypoglycemic coma (HP:0001325)1.94802382
79Spondylolisthesis (HP:0003302)1.94320929
80Microretrognathia (HP:0000308)1.93353427
81Abnormality of the right ventricle (HP:0001707)1.92584328
82Abnormality of transition element cation homeostasis (HP:0011030)1.91867977
83Bone pain (HP:0002653)1.91525808
84Recurrent skin infections (HP:0001581)1.90605122
85Thoracic kyphosis (HP:0002942)1.90085804
86Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89516310
87Abnormal hemoglobin (HP:0011902)1.89098555
88Neuronal loss in central nervous system (HP:0002529)1.89019529
89Abnormal cartilage morphology (HP:0002763)1.88785212
90Gastrointestinal infarctions (HP:0005244)1.88493193
91Astrocytoma (HP:0009592)1.88215158
92Abnormality of the astrocytes (HP:0100707)1.88215158
93Flat acetabular roof (HP:0003180)1.86516958
94Prolonged neonatal jaundice (HP:0006579)1.85974411
95Urticaria (HP:0001025)1.85594228
96Prolonged bleeding time (HP:0003010)1.85103043
97Abnormality of the salivary glands (HP:0010286)1.84278600
98Disinhibition (HP:0000734)1.83828802
99Rectovaginal fistula (HP:0000143)1.83812956
100Rectal fistula (HP:0100590)1.83812956
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83474366
102Gastrointestinal dysmotility (HP:0002579)1.83215982
103Colon cancer (HP:0003003)1.82776786
104Polygenic inheritance (HP:0010982)1.82618046
105Upper motor neuron abnormality (HP:0002127)1.82003724
106Abnormality of the nasal mucosa (HP:0000433)1.81771144
107Mitral stenosis (HP:0001718)1.81766302
108Gastrointestinal carcinoma (HP:0002672)1.80586989
109Malignant gastrointestinal tract tumors (HP:0006749)1.80586989
110Recurrent abscess formation (HP:0002722)1.80073441
111Abnormality of the thoracic spine (HP:0100711)1.79995379
112Supernumerary spleens (HP:0009799)1.79924574
113Segmental peripheral demyelination/remyelination (HP:0003481)1.79796999
114Glomerulonephritis (HP:0000099)1.79712069
115Recurrent gram-negative bacterial infections (HP:0005420)1.79257075
116Hyperinsulinemic hypoglycemia (HP:0000825)1.77898921
117Malnutrition (HP:0004395)1.77888440
118Autoimmune thrombocytopenia (HP:0001973)1.77518820
119Aplasia/hypoplasia of the humerus (HP:0006507)1.77193620
120Vertebral hypoplasia (HP:0008417)1.77124054
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77124054
122Shallow orbits (HP:0000586)1.76398027
123Generalized amyotrophy (HP:0003700)1.76335412
124Xanthomatosis (HP:0000991)1.75849780
125Abnormality of iron homeostasis (HP:0011031)1.75742464
126Peritonitis (HP:0002586)1.74931864
127Abnormality of the fetal cardiovascular system (HP:0010948)1.74325285
128Abnormal umbilical cord blood vessels (HP:0011403)1.74325285
129Single umbilical artery (HP:0001195)1.74325285
130Lymphangioma (HP:0100764)1.74110351
131Muscle fibrillation (HP:0010546)1.73703504
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.72775769
133Pathologic fracture (HP:0002756)1.72304418
134Complement deficiency (HP:0004431)1.72013040
135Abnormality of complement system (HP:0005339)1.70568879
136Increased IgE level (HP:0003212)1.70364317
137Hypertriglyceridemia (HP:0002155)1.69464252
138Partial duplication of the phalanx of hand (HP:0009999)1.68749735
139Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68092670
140Aortic aneurysm (HP:0004942)1.68031498
141Short humerus (HP:0005792)1.67769173
142Abnormal number of incisors (HP:0011064)1.67655109
143Aneurysm (HP:0002617)1.67468827
144Trismus (HP:0000211)1.67351018
145Cardiomegaly (HP:0001640)1.66444193
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65989516
147Tongue fasciculations (HP:0001308)1.65574619
148Abnormal platelet function (HP:0011869)1.65387585
149Impaired platelet aggregation (HP:0003540)1.65387585
150Diminished motivation (HP:0000745)1.65296327
151J-shaped sella turcica (HP:0002680)1.65196979
152Supranuclear gaze palsy (HP:0000605)1.65041401
153Joint stiffness (HP:0001387)1.64680225
154Joint hemorrhage (HP:0005261)1.64653888
155Recurrent bacterial skin infections (HP:0005406)1.64154168
156Bulbar palsy (HP:0001283)1.63981819
157Exercise-induced muscle cramps (HP:0003710)1.63699504
158Blue sclerae (HP:0000592)1.63490847
159Abnormal neuron morphology (HP:0012757)1.62152313
160Abnormality of the motor neurons (HP:0002450)1.62152313
161Skin nodule (HP:0200036)1.60692487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.54478972
2TIE14.94700439
3IRAK33.14863898
4PRPF4B2.90258116
5ERN12.85167368
6TRIB32.60262448
7EPHA22.58559733
8BLK2.58421636
9PRKG22.45388547
10PKN22.44151945
11FLT32.20176571
12MAP3K112.14406592
13BUB12.08953994
14TAOK22.04550302
15SMG12.02024179
16RIPK12.00157714
17RIPK41.90359434
18BMX1.85955827
19MAP3K101.83872990
20MET1.81136295
21TGFBR21.73832363
22IRAK41.71109993
23TBK11.68077122
24TAOK11.65427650
25MAP4K11.60400908
26PAK41.59376393
27CAMK1D1.56557951
28CDK121.55931363
29TSSK61.55437713
30CSK1.54314712
31BCKDK1.53895508
32SCYL21.41508133
33EPHB11.40946452
34PASK1.40518703
35FGFR41.39134703
36MAP3K11.34446463
37GRK61.30958046
38MAP3K141.30948292
39RPS6KB21.30874856
40LRRK21.29087877
41STK101.28955304
42PDGFRA1.26540660
43FGR1.25368844
44NME21.23337490
45MAP3K81.15171816
46MAP2K21.14526581
47TTK1.14285589
48KDR1.13293731
49KSR21.12405530
50ARAF1.11723560
51EEF2K1.11475533
52CDC42BPA1.10865381
53PDPK11.10772802
54MAP3K131.09427348
55LATS21.07983151
56INSRR1.07695400
57NEK21.07381321
58WEE11.07316024
59TTN1.06792370
60PRKD21.06030225
61NEK91.04750402
62NEK11.00043009
63MTOR0.99826608
64MARK20.98981072
65CDK70.98875502
66CDK40.98652539
67MAP3K60.98029359
68FES0.95407476
69SIK30.95159295
70TGFBR10.94420733
71ZAP700.90977104
72MAP2K30.89859629
73TNK20.89679388
74PTK60.89128235
75IRAK20.88038814
76PTK20.86515023
77ZAK0.84772957
78CDK60.84702462
79RPS6KA20.84082182
80MAPKAPK30.83635136
81TRPM70.82791868
82STK38L0.80847299
83CSF1R0.79027235
84HCK0.78508724
85IKBKE0.76317339
86ILK0.74260325
87PIM20.73569804
88DDR20.72883104
89ALK0.71981625
90TEC0.71831942
91RPS6KL10.71630415
92RPS6KC10.71630415
93PDK10.70598463
94TYK20.70371957
95SIK10.70231253
96MATK0.69095042
97PAK10.68910871
98MAP2K10.68554956
99BRD40.66605361
100JAK10.65113175
101PIM10.64747836
102MAP3K20.64327129
103MST1R0.60704571
104BTK0.60204869
105GRK10.59863192
106PRKCI0.58518704
107AKT30.57890954
108PAK20.57538219
109RPS6KA40.56534248
110DYRK30.56481533
111PRKD30.56006039
112JAK20.54786915
113PLK10.52786712
114DMPK0.52231781
115MAP3K30.52169981
116STK380.50623996
117CAMK1G0.50223753
118AURKA0.50148346
119RPS6KA60.50096333
120MAPK110.50020446
121HIPK20.48931298
122ABL20.48755076
123MOS0.48722708
124RET0.48588498
125FGFR10.48190626
126MAPK120.47562915
127CDC70.46880116
128ICK0.46858298
129STK240.46589692
130AKT20.46059856
131MAP3K50.45895878
132LYN0.45700353
133GRK70.45532101
134TESK10.44912047
135IKBKB0.44119042
136MAPKAPK20.41854738
137NTRK10.41820405
138STK40.38879720
139IRAK10.38836138
140LCK0.38731046
141SYK0.38189160
142ATR0.38051691
143BRAF0.37911132
144PRKCD0.35879381
145ACVR1B0.33981432
146ADRBK20.32532811
147DAPK30.32146531
148DYRK1B0.31425962
149EGFR0.30963547
150JAK30.30837541
151MAPK10.30073995
152TESK20.29750887
153CDK20.28563761
154AURKB0.27976255
155KIT0.27963142

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.76355667
2DNA replication_Homo sapiens_hsa030302.62440282
3Mismatch repair_Homo sapiens_hsa034302.61830313
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46766830
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.45025963
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43364111
7Osteoclast differentiation_Homo sapiens_hsa043802.34170450
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.26947589
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.14309657
10Other glycan degradation_Homo sapiens_hsa005112.00476797
11Lysosome_Homo sapiens_hsa041421.96833704
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96307008
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.89591893
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87201897
15Ribosome_Homo sapiens_hsa030101.85885955
16Folate biosynthesis_Homo sapiens_hsa007901.85355399
17Staphylococcus aureus infection_Homo sapiens_hsa051501.80283778
18Base excision repair_Homo sapiens_hsa034101.75463689
19Biosynthesis of amino acids_Homo sapiens_hsa012301.74755900
20Malaria_Homo sapiens_hsa051441.65348221
21Tuberculosis_Homo sapiens_hsa051521.65321674
22Acute myeloid leukemia_Homo sapiens_hsa052211.64720295
23RNA transport_Homo sapiens_hsa030131.63619343
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57220905
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57095083
26Fructose and mannose metabolism_Homo sapiens_hsa000511.55645000
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54585465
28B cell receptor signaling pathway_Homo sapiens_hsa046621.51217486
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48057180
30Pertussis_Homo sapiens_hsa051331.47343043
31Selenocompound metabolism_Homo sapiens_hsa004501.46925223
32Sulfur relay system_Homo sapiens_hsa041221.46398235
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43586902
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43116678
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42037822
36Carbon metabolism_Homo sapiens_hsa012001.38579605
37Toxoplasmosis_Homo sapiens_hsa051451.38144187
38Proteasome_Homo sapiens_hsa030501.37807792
39Nucleotide excision repair_Homo sapiens_hsa034201.26516858
40TNF signaling pathway_Homo sapiens_hsa046681.26418343
41p53 signaling pathway_Homo sapiens_hsa041151.25525880
42Pancreatic cancer_Homo sapiens_hsa052121.21583390
43Non-small cell lung cancer_Homo sapiens_hsa052231.19465430
44Salmonella infection_Homo sapiens_hsa051321.18053163
45Complement and coagulation cascades_Homo sapiens_hsa046101.17763693
46Pentose phosphate pathway_Homo sapiens_hsa000301.17510486
47VEGF signaling pathway_Homo sapiens_hsa043701.16844081
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16688416
49Galactose metabolism_Homo sapiens_hsa000521.15419125
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14161457
51Homologous recombination_Homo sapiens_hsa034401.13639606
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.12724467
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.11866989
54Influenza A_Homo sapiens_hsa051641.09562262
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09486300
56Adherens junction_Homo sapiens_hsa045201.08299679
57Hepatitis C_Homo sapiens_hsa051601.06886413
58Allograft rejection_Homo sapiens_hsa053301.06838501
59Amoebiasis_Homo sapiens_hsa051461.06566585
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04026400
61Rheumatoid arthritis_Homo sapiens_hsa053231.02521726
62Cell cycle_Homo sapiens_hsa041101.01871688
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01642546
64Shigellosis_Homo sapiens_hsa051311.00344686
65Tryptophan metabolism_Homo sapiens_hsa003800.97132010
66Bladder cancer_Homo sapiens_hsa052190.96508713
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.95060894
68Chemokine signaling pathway_Homo sapiens_hsa040620.94386380
69Hepatitis B_Homo sapiens_hsa051610.93782782
70Nitrogen metabolism_Homo sapiens_hsa009100.93631956
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93540964
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93353873
73Viral myocarditis_Homo sapiens_hsa054160.92203393
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91317923
75Proteoglycans in cancer_Homo sapiens_hsa052050.91306972
76Graft-versus-host disease_Homo sapiens_hsa053320.91114173
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.90570330
78Vibrio cholerae infection_Homo sapiens_hsa051100.89949246
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89903863
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89004437
81Endocytosis_Homo sapiens_hsa041440.88628919
82HIF-1 signaling pathway_Homo sapiens_hsa040660.87267069
83Pyrimidine metabolism_Homo sapiens_hsa002400.85883934
84Legionellosis_Homo sapiens_hsa051340.85201353
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84657043
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.84331939
87Autoimmune thyroid disease_Homo sapiens_hsa053200.83586094
88Sphingolipid metabolism_Homo sapiens_hsa006000.83013143
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81292419
90Renal cell carcinoma_Homo sapiens_hsa052110.80575320
91Endometrial cancer_Homo sapiens_hsa052130.79739013
92Measles_Homo sapiens_hsa051620.78944184
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.78037707
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77893287
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77524065
96Starch and sucrose metabolism_Homo sapiens_hsa005000.77486472
97RNA polymerase_Homo sapiens_hsa030200.76727736
98Phenylalanine metabolism_Homo sapiens_hsa003600.73476207
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72932468
100PPAR signaling pathway_Homo sapiens_hsa033200.72623014
101Herpes simplex infection_Homo sapiens_hsa051680.70305720
102Hematopoietic cell lineage_Homo sapiens_hsa046400.70228475
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.70011267
104Spliceosome_Homo sapiens_hsa030400.69487626
105African trypanosomiasis_Homo sapiens_hsa051430.69347781
106Fatty acid degradation_Homo sapiens_hsa000710.69303421
107Platelet activation_Homo sapiens_hsa046110.68631107
108Prolactin signaling pathway_Homo sapiens_hsa049170.67878427
109Glutathione metabolism_Homo sapiens_hsa004800.67329299
110Insulin resistance_Homo sapiens_hsa049310.67240943
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66743709
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.66426462
113Thyroid cancer_Homo sapiens_hsa052160.66402222
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64792556
115TGF-beta signaling pathway_Homo sapiens_hsa043500.64657106
116Prion diseases_Homo sapiens_hsa050200.64429892
117Hippo signaling pathway_Homo sapiens_hsa043900.64003742
118Insulin signaling pathway_Homo sapiens_hsa049100.62928447
119Chemical carcinogenesis_Homo sapiens_hsa052040.62414873
120Apoptosis_Homo sapiens_hsa042100.61967611
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61925968
122Arginine and proline metabolism_Homo sapiens_hsa003300.61434739
123Antigen processing and presentation_Homo sapiens_hsa046120.60460121
124MicroRNAs in cancer_Homo sapiens_hsa052060.60044580
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.56847882
126Arginine biosynthesis_Homo sapiens_hsa002200.56093696
127Chronic myeloid leukemia_Homo sapiens_hsa052200.56018193
128Bile secretion_Homo sapiens_hsa049760.55492361
129Peroxisome_Homo sapiens_hsa041460.54684193
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54665089
131Small cell lung cancer_Homo sapiens_hsa052220.54559252
132T cell receptor signaling pathway_Homo sapiens_hsa046600.53228432
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.53146495
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.52677718
135Asthma_Homo sapiens_hsa053100.52133149
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51341917
137Phagosome_Homo sapiens_hsa041450.51244403
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50907375
139mTOR signaling pathway_Homo sapiens_hsa041500.50736906
140Tyrosine metabolism_Homo sapiens_hsa003500.48308967
141GnRH signaling pathway_Homo sapiens_hsa049120.48265783
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47653312
143Glioma_Homo sapiens_hsa052140.47574223
144Prostate cancer_Homo sapiens_hsa052150.47558414
145Notch signaling pathway_Homo sapiens_hsa043300.46336220
146ABC transporters_Homo sapiens_hsa020100.46304303
147Focal adhesion_Homo sapiens_hsa045100.45778249
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45635400
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45392654
150Type I diabetes mellitus_Homo sapiens_hsa049400.43862623
151Retinol metabolism_Homo sapiens_hsa008300.42521260
152Choline metabolism in cancer_Homo sapiens_hsa052310.42191844
153Leishmaniasis_Homo sapiens_hsa051400.39346352
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39155910
155Viral carcinogenesis_Homo sapiens_hsa052030.38937034
156HTLV-I infection_Homo sapiens_hsa051660.38833046
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38783835
158Melanoma_Homo sapiens_hsa052180.38583024
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38098778
160Basal cell carcinoma_Homo sapiens_hsa052170.37229897
161Lysine degradation_Homo sapiens_hsa003100.37072517
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36735127
163beta-Alanine metabolism_Homo sapiens_hsa004100.35767471

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