HS3ST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.81273098
2ensheathment of neurons (GO:0007272)6.46330960
3axon ensheathment (GO:0008366)6.46330960
4myelination (GO:0042552)6.41880741
5long-chain fatty acid biosynthetic process (GO:0042759)5.66250503
6negative regulation of neurotransmitter secretion (GO:0046929)5.28331005
7water-soluble vitamin biosynthetic process (GO:0042364)5.10595669
8negative regulation of neurotransmitter transport (GO:0051589)4.88469420
9myelin maintenance (GO:0043217)4.83488260
10presynaptic membrane organization (GO:0097090)4.76136991
11apical protein localization (GO:0045176)4.69124305
12protein complex biogenesis (GO:0070271)4.64838456
13presynaptic membrane assembly (GO:0097105)4.62433369
14behavioral response to nicotine (GO:0035095)4.61755995
15oligodendrocyte differentiation (GO:0048709)4.56336242
16sulfation (GO:0051923)4.46925089
17negative regulation of protein localization to cell surface (GO:2000009)4.35776689
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.22603036
19NADH dehydrogenase complex assembly (GO:0010257)4.22603036
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.22603036
21regulation of collateral sprouting (GO:0048670)4.21628410
22negative regulation of membrane potential (GO:0045837)4.21250386
23asymmetric protein localization (GO:0008105)4.20300342
24monoubiquitinated protein deubiquitination (GO:0035520)4.19183401
25establishment of mitochondrion localization (GO:0051654)4.18943426
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.18107321
27mitochondrial respiratory chain complex assembly (GO:0033108)4.07490392
28adhesion of symbiont to host cell (GO:0044650)4.06595388
29virion attachment to host cell (GO:0019062)4.06595388
30negative regulation of systemic arterial blood pressure (GO:0003085)3.99435618
31interferon-gamma secretion (GO:0072643)3.96606032
32astrocyte development (GO:0014002)3.93411272
33regulation of germinal center formation (GO:0002634)3.89632809
34photoreceptor cell differentiation (GO:0046530)3.87588961
35eye photoreceptor cell differentiation (GO:0001754)3.87588961
36negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.80394442
37creatine metabolic process (GO:0006600)3.78316329
38adaptation of signaling pathway (GO:0023058)3.75063514
39glycerophospholipid catabolic process (GO:0046475)3.74140062
40peptidyl-tyrosine autophosphorylation (GO:0038083)3.69581927
41neuron cell-cell adhesion (GO:0007158)3.66899977
42DNA deamination (GO:0045006)3.66616039
43L-amino acid import (GO:0043092)3.64862112
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.62396082
45negative regulation of mast cell activation (GO:0033004)3.62034685
46response to xenobiotic stimulus (GO:0009410)3.60564712
47substantia nigra development (GO:0021762)3.55120637
48purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.54601600
493-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.54601600
50neuronal action potential propagation (GO:0019227)3.51222381
51regulation of glomerulus development (GO:0090192)3.50311661
52endoderm formation (GO:0001706)3.49854372
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.49189664
54cholesterol biosynthetic process (GO:0006695)3.48771910
55cellular response to ATP (GO:0071318)3.48554900
56positive regulation of action potential (GO:0045760)3.48374685
57import into cell (GO:0098657)3.47454063
58positive regulation of endothelial cell differentiation (GO:0045603)3.43503090
59positive regulation of fatty acid transport (GO:2000193)3.40052698
60response to methylmercury (GO:0051597)3.37179455
61adult walking behavior (GO:0007628)3.36802570
62base-excision repair, AP site formation (GO:0006285)3.36573112
63positive regulation of oligodendrocyte differentiation (GO:0048714)3.36012653
64cellular response to exogenous dsRNA (GO:0071360)3.31367619
65prostate gland growth (GO:0060736)3.24283274
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.24042786
67cerebral cortex radially oriented cell migration (GO:0021799)3.21029256
68membrane tubulation (GO:0097320)3.16363741
69membrane repolarization during action potential (GO:0086011)3.16097346
70positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.16012056
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.15263304
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15075326
73peripheral nervous system axon ensheathment (GO:0032292)3.13926147
74myelination in peripheral nervous system (GO:0022011)3.13926147
75limb bud formation (GO:0060174)3.13858475
76positive regulation of potassium ion transmembrane transport (GO:1901381)3.13654268
77amyloid precursor protein metabolic process (GO:0042982)3.13374328
78cerebellar granule cell differentiation (GO:0021707)3.13064322
79indolalkylamine metabolic process (GO:0006586)3.11885664
80positive regulation of glomerulus development (GO:0090193)3.10482160
81cell proliferation in forebrain (GO:0021846)3.10415939
82negative regulation of axonogenesis (GO:0050771)3.08894232
83negative regulation of JUN kinase activity (GO:0043508)3.08415968
84protein polyglutamylation (GO:0018095)3.07534625
85neuron remodeling (GO:0016322)3.06393629
86transmission of nerve impulse (GO:0019226)3.06151096
87response to redox state (GO:0051775)3.04447578
88sterol biosynthetic process (GO:0016126)3.02588010
89ovulation cycle (GO:0042698)2.99947458
90adhesion of symbiont to host (GO:0044406)2.99342268
91positive regulation of defense response to virus by host (GO:0002230)2.99010540
92positive regulation of triglyceride biosynthetic process (GO:0010867)2.98970830
93ear development (GO:0043583)2.97395461
94glycosylceramide metabolic process (GO:0006677)2.97161026
95protein K48-linked deubiquitination (GO:0071108)2.96766771
96regulation of endothelial cell differentiation (GO:0045601)2.96526340
97regulation of receptor binding (GO:1900120)2.95824121
98membrane assembly (GO:0071709)2.95709777
99protein palmitoylation (GO:0018345)2.94797903
100negative regulation of DNA-templated transcription, elongation (GO:0032785)2.93424968
101negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93197781
102magnesium ion transport (GO:0015693)2.92718533
103somite development (GO:0061053)2.90513926
104negative regulation of T cell differentiation in thymus (GO:0033085)2.87894677
105neuronal ion channel clustering (GO:0045161)2.87025610
106negative regulation of protein tyrosine kinase activity (GO:0061099)2.85384133
107kynurenine metabolic process (GO:0070189)2.85269629
108serotonin metabolic process (GO:0042428)2.85237262
109gamma-aminobutyric acid transport (GO:0015812)2.84852536
110axon development (GO:0061564)2.84424037
111dentate gyrus development (GO:0021542)2.83449598
112vitamin biosynthetic process (GO:0009110)2.81730824
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80916505
114amino acid import (GO:0043090)2.79760559
115peripheral nervous system development (GO:0007422)2.79292629
116cellular response to epinephrine stimulus (GO:0071872)2.78204555
117response to gravity (GO:0009629)2.76109385
118fatty-acyl-CoA biosynthetic process (GO:0046949)2.75798983
119fatty-acyl-CoA metabolic process (GO:0035337)2.75007881
120isoprenoid biosynthetic process (GO:0008299)2.74929899
121primary amino compound metabolic process (GO:1901160)2.74691205
122tryptophan catabolic process (GO:0006569)2.74123730
123indole-containing compound catabolic process (GO:0042436)2.74123730
124indolalkylamine catabolic process (GO:0046218)2.74123730
125regulation of lipoprotein metabolic process (GO:0050746)2.73788489
126regulation of mesoderm development (GO:2000380)2.73652327
127platelet dense granule organization (GO:0060155)2.72069923
128positive regulation of prostaglandin secretion (GO:0032308)2.71874517
129neurotransmitter uptake (GO:0001504)2.71391114
130nucleotide transmembrane transport (GO:1901679)2.70589300
131response to epinephrine (GO:0071871)2.70132679
132pharyngeal system development (GO:0060037)2.69655026
133regulation of cholesterol storage (GO:0010885)2.67834051
134gamma-aminobutyric acid signaling pathway (GO:0007214)2.67686571
135branching involved in labyrinthine layer morphogenesis (GO:0060670)2.67671466
136GPI anchor biosynthetic process (GO:0006506)2.63087295
137GPI anchor metabolic process (GO:0006505)2.61432192
138negative regulation of axon extension (GO:0030517)2.61347628
139protein import into peroxisome matrix (GO:0016558)2.60197607
140negative regulation of inclusion body assembly (GO:0090084)2.60177256
141pyrimidine nucleotide catabolic process (GO:0006244)2.58185824
142neuron recognition (GO:0008038)2.57795755
143negative regulation of execution phase of apoptosis (GO:1900118)2.57411205
144organ growth (GO:0035265)2.57410842
145indole-containing compound metabolic process (GO:0042430)2.55713090
146peptidyl-cysteine modification (GO:0018198)2.55437726
147regulation of voltage-gated calcium channel activity (GO:1901385)2.54552721
148Golgi to endosome transport (GO:0006895)2.54358169
149positive regulation of icosanoid secretion (GO:0032305)2.54290504
150regulation of skeletal muscle contraction (GO:0014819)2.54122292
151cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.51975146
152response to lipoprotein particle (GO:0055094)2.51729540
153interferon-gamma production (GO:0032609)2.49795601
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49132668
155axonemal dynein complex assembly (GO:0070286)2.48354628
156negative regulation of lipid storage (GO:0010888)2.48194852
157epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47645262
158mechanosensory behavior (GO:0007638)2.47036752
159parturition (GO:0007567)2.46663542
160glial cell differentiation (GO:0010001)2.45486338
161axoneme assembly (GO:0035082)2.45270611
162cytochrome complex assembly (GO:0017004)2.45227770
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.44837764
164interleukin-6-mediated signaling pathway (GO:0070102)2.44393054
165glial cell development (GO:0021782)2.44356566
166dendritic spine morphogenesis (GO:0060997)2.44070603
167cellular potassium ion homeostasis (GO:0030007)2.43315938
168negative regulation of synaptic transmission (GO:0050805)2.42590354
169neural nucleus development (GO:0048857)2.41495147
170positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.41415878
171mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.41415878
172mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41073014
173epithelial cilium movement (GO:0003351)2.40825043
174leukocyte migration involved in inflammatory response (GO:0002523)2.40441868
175response to monoamine (GO:0071867)2.39831659
176response to catecholamine (GO:0071869)2.39831659
177regulation of cilium movement (GO:0003352)2.38467941
178embryonic skeletal joint morphogenesis (GO:0060272)2.38439485
179regulation of cell proliferation involved in kidney development (GO:1901722)2.37377600
180cellular anion homeostasis (GO:0030002)2.37332042
181negative regulation of appetite (GO:0032099)2.37007535
182negative regulation of response to food (GO:0032096)2.37007535
183preassembly of GPI anchor in ER membrane (GO:0016254)2.36799248
184negative regulation of blood pressure (GO:0045776)2.36510944
185positive regulation of glial cell differentiation (GO:0045687)2.36209567
186cellular response to catecholamine stimulus (GO:0071870)2.34521595
187smooth muscle tissue development (GO:0048745)2.32206409
188positive regulation of calcium-mediated signaling (GO:0050850)2.31164460
189positive regulation of fatty acid oxidation (GO:0046321)2.30760230
190auditory behavior (GO:0031223)2.29570605
191cobalamin metabolic process (GO:0009235)2.28251729
192positive regulation of heat generation (GO:0031652)2.27727253
193detection of light stimulus involved in visual perception (GO:0050908)2.27670616
194detection of light stimulus involved in sensory perception (GO:0050962)2.27670616
195central nervous system myelination (GO:0022010)10.2443909
196axon ensheathment in central nervous system (GO:0032291)10.2443909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.69035833
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.38706041
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.10337361
4TAF15_26573619_Chip-Seq_HEK293_Human2.57784118
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55766648
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50644015
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50615562
8* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.42360567
9EZH2_22144423_ChIP-Seq_EOC_Human2.40472369
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37680995
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.35648420
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.35305326
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20546929
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20546929
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20483959
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.15441184
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10153706
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07172519
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01415089
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00502632
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.00456557
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00105157
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99521716
24* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99183611
25ZNF274_21170338_ChIP-Seq_K562_Hela1.99169819
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95678862
27* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95277364
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.89839373
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85724212
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84889117
31VDR_22108803_ChIP-Seq_LS180_Human1.83616505
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77297521
33ER_23166858_ChIP-Seq_MCF-7_Human1.72482833
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.71764174
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70906053
36IRF1_19129219_ChIP-ChIP_H3396_Human1.70522960
37AR_21572438_ChIP-Seq_LNCaP_Human1.68669797
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68081736
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66498461
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.60982976
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60384962
42* SMAD3_21741376_ChIP-Seq_EPCs_Human1.57262398
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.54778109
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54762067
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54423348
46DROSHA_22980978_ChIP-Seq_HELA_Human1.51739835
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50458470
48* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50264729
49FUS_26573619_Chip-Seq_HEK293_Human1.50099394
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.49528843
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49482954
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49124876
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.48474980
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47205679
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44886961
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44043907
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43095677
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.42442054
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40334512
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39993589
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36695621
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.35470387
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34795179
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32261316
65P300_19829295_ChIP-Seq_ESCs_Human1.30990866
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28409030
67NCOR_22424771_ChIP-Seq_293T_Human1.27944846
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27873304
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.27547926
70IGF1R_20145208_ChIP-Seq_DFB_Human1.26850705
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26020419
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24547203
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22881163
74REST_21632747_ChIP-Seq_MESCs_Mouse1.22818890
75SMAD4_21799915_ChIP-Seq_A2780_Human1.22059889
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21917217
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.20364806
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19817541
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19107954
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18784137
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17250035
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17250035
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16330886
84AHR_22903824_ChIP-Seq_MCF-7_Human1.16195279
85STAT3_23295773_ChIP-Seq_U87_Human1.16118586
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.14626633
87BCAT_22108803_ChIP-Seq_LS180_Human1.13534923
88RNF2_27304074_Chip-Seq_NSC_Mouse1.12248219
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.11242928
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10464858
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09897350
92TAF2_19829295_ChIP-Seq_ESCs_Human1.09819962
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09371452
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09195063
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08598204
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08425218
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07084937
98CBP_20019798_ChIP-Seq_JUKART_Human1.06710534
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06710534
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04866517
101RXR_22108803_ChIP-Seq_LS180_Human1.04741731
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.03834267
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.03650381
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03650381
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03650058
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03123317
107EWS_26573619_Chip-Seq_HEK293_Human1.02937407
108* TCF4_23295773_ChIP-Seq_U87_Human1.02192247
109* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00728970
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.00627779
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00207431
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.99710965
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99533337
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98348586
115TP53_18474530_ChIP-ChIP_U2OS_Human0.97597558
116SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97555478
117CMYC_18555785_Chip-Seq_ESCs_Mouse0.96819109
118MYC_19829295_ChIP-Seq_ESCs_Human0.96687418
119* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96613725
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96184470
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95544878
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95534069
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94203042
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.94171999
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93814912
126STAT1_20625510_ChIP-Seq_HELA_Human0.93619065
127* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93068973
128LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92372494
129CTCF_20526341_ChIP-Seq_ESCs_Human0.92311562
130EOMES_21245162_ChIP-Seq_HESCs_Human0.92102583
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92068880
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.91992923
133PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91776021
134RUNX2_22187159_ChIP-Seq_PCA_Human0.91486983
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90823669
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90581732
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90388943
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.89878273
139SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89728118
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88959966
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88675052
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88663627
143BCL6_27268052_Chip-Seq_Bcells_Human0.88628600
144P300_18555785_Chip-Seq_ESCs_Mouse0.88475865
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.88400142
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87503042
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87442580
148RUNX_20019798_ChIP-Seq_JUKART_Human0.86340588
149KDM2B_26808549_Chip-Seq_REH_Human0.86299321
150FOXH1_21741376_ChIP-Seq_ESCs_Human0.86122288
151EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85561679
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85556783
153ERA_21632823_ChIP-Seq_H3396_Human0.85210870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.07801305
2MP0002837_dystrophic_cardiac_calcinosis4.93923796
3MP0000920_abnormal_myelination4.84698892
4MP0003880_abnormal_central_pattern4.35495221
5MP0004270_analgesia3.67411953
6MP0003011_delayed_dark_adaptation3.11177254
7MP0003329_amyloid_beta_deposits2.87278660
8MP0003950_abnormal_plasma_membrane2.80860466
9MP0003690_abnormal_glial_cell2.75935061
10MP0002272_abnormal_nervous_system2.64393665
11MP0004859_abnormal_synaptic_plasticity2.63324468
12MP0005171_absent_coat_pigmentation2.52602395
13MP0001486_abnormal_startle_reflex2.51429849
14MP0001529_abnormal_vocalization2.50899220
15MP0004885_abnormal_endolymph2.50504141
16MP0001905_abnormal_dopamine_level2.47231489
17MP0002064_seizures2.46859661
18MP0001485_abnormal_pinna_reflex2.45569895
19MP0004742_abnormal_vestibular_system2.43760256
20MP0005670_abnormal_white_adipose2.33617232
21MP0009046_muscle_twitch2.30215783
22MP0003136_yellow_coat_color2.23296342
23MP0002138_abnormal_hepatobiliary_system2.20395938
24MP0003634_abnormal_glial_cell2.18045048
25MP0005671_abnormal_response_to2.15169472
26MP0000778_abnormal_nervous_system2.13597320
27MP0003724_increased_susceptibility_to2.11897124
28MP0009745_abnormal_behavioral_response2.11189309
29MP0003635_abnormal_synaptic_transmissio2.10936700
30MP0004142_abnormal_muscle_tone2.04408769
31MP0004147_increased_porphyrin_level1.99529796
32MP0002734_abnormal_mechanical_nocicepti1.96122896
33MP0002148_abnormal_hypersensitivity_rea1.91618204
34MP0005623_abnormal_meninges_morphology1.85712277
35MP0005409_darkened_coat_color1.77965984
36MP0002229_neurodegeneration1.77525868
37MP0003632_abnormal_nervous_system1.74987032
38MP0009764_decreased_sensitivity_to1.72802857
39MP0005423_abnormal_somatic_nervous1.69248758
40MP0002572_abnormal_emotion/affect_behav1.63900429
41MP0002160_abnormal_reproductive_system1.61144607
42MP0004130_abnormal_muscle_cell1.59101861
43MP0001440_abnormal_grooming_behavior1.57805069
44MP0008875_abnormal_xenobiotic_pharmacok1.55698987
45MP0004043_abnormal_pH_regulation1.55037029
46MP0002063_abnormal_learning/memory/cond1.54689201
47MP0005389_reproductive_system_phenotype1.54437760
48MP0010678_abnormal_skin_adnexa1.53540683
49MP0001853_heart_inflammation1.51959856
50MP0005410_abnormal_fertilization1.50362907
51MP0000537_abnormal_urethra_morphology1.49272940
52MP0000343_altered_response_to1.48903896
53MP0001963_abnormal_hearing_physiology1.46802231
54MP0008775_abnormal_heart_ventricle1.46211043
55MP0002067_abnormal_sensory_capabilities1.44908023
56MP0004185_abnormal_adipocyte_glucose1.44451064
57MP0004924_abnormal_behavior1.43615672
58MP0005386_behavior/neurological_phenoty1.43615672
59MP0002653_abnormal_ependyma_morphology1.43497966
60MP0000383_abnormal_hair_follicle1.42709976
61MP0002277_abnormal_respiratory_mucosa1.42126977
62MP0001970_abnormal_pain_threshold1.42026570
63MP0008789_abnormal_olfactory_epithelium1.41163841
64MP0005551_abnormal_eye_electrophysiolog1.39278756
65MP0003631_nervous_system_phenotype1.38201747
66MP0002882_abnormal_neuron_morphology1.37777669
67MP0000955_abnormal_spinal_cord1.36839542
68MP0000604_amyloidosis1.35972279
69MP0000462_abnormal_digestive_system1.32307474
70MP0002733_abnormal_thermal_nociception1.31443596
71MP0005084_abnormal_gallbladder_morpholo1.31316005
72MP0008569_lethality_at_weaning1.30874708
73MP0006292_abnormal_olfactory_placode1.30437424
74MP0005253_abnormal_eye_physiology1.29771495
75MP0008872_abnormal_physiological_respon1.26581684
76MP0002066_abnormal_motor_capabilities/c1.25777662
77MP0002735_abnormal_chemical_nociception1.22364853
78MP0000049_abnormal_middle_ear1.22251256
79MP0004272_abnormal_basement_membrane1.22224594
80MP0005000_abnormal_immune_tolerance1.21422392
81MP0002876_abnormal_thyroid_physiology1.20427578
82MP0003633_abnormal_nervous_system1.18913430
83MP0004381_abnormal_hair_follicle1.17904993
84MP0001919_abnormal_reproductive_system1.16346833
85MP0000685_abnormal_immune_system1.14931646
86MP0002752_abnormal_somatic_nervous1.14560513
87MP0001968_abnormal_touch/_nociception1.14129819
88MP0003123_paternal_imprinting1.13703768
89MP0002139_abnormal_hepatobiliary_system1.11934296
90MP0009785_altered_susceptibility_to1.10685751
91MP0009765_abnormal_xenobiotic_induced1.09460919
92MP0001790_abnormal_immune_system1.08219990
93MP0005387_immune_system_phenotype1.08219990
94MP0004145_abnormal_muscle_electrophysio1.08124511
95MP0005167_abnormal_blood-brain_barrier1.06547141
96MP0001501_abnormal_sleep_pattern1.03744994
97MP0000230_abnormal_systemic_arterial1.03193180
98MP0005058_abnormal_lysosome_morphology1.01277557
99MP0004134_abnormal_chest_morphology1.00222537
100MP0000747_muscle_weakness0.98480865
101MP0000026_abnormal_inner_ear0.96184003
102MP0001299_abnormal_eye_distance/0.96054259
103MP0003938_abnormal_ear_development0.92325510
104MP0002736_abnormal_nociception_after0.91677914
105MP0006082_CNS_inflammation0.91203622
106MP0009053_abnormal_anal_canal0.90963976
107MP0002557_abnormal_social/conspecific_i0.90742701
108MP0001835_abnormal_antigen_presentation0.90630699
109MP0005195_abnormal_posterior_eye0.90542614
110MP0001800_abnormal_humoral_immune0.90263842
111MP0003890_abnormal_embryonic-extraembry0.90065773
112MP0005646_abnormal_pituitary_gland0.89224335
113MP0000538_abnormal_urinary_bladder0.89011380
114MP0002184_abnormal_innervation0.88389287
115MP0002638_abnormal_pupillary_reflex0.87890944
116MP0001851_eye_inflammation0.87369770
117MP0002152_abnormal_brain_morphology0.87312733
118MP0008877_abnormal_DNA_methylation0.86831308
119MP0002452_abnormal_antigen_presenting0.86796365
120MP0000631_abnormal_neuroendocrine_gland0.86795329
121MP0003879_abnormal_hair_cell0.85540913
122MP0002723_abnormal_immune_serum0.84842942
123MP0005451_abnormal_body_composition0.84442732
124MP0001346_abnormal_lacrimal_gland0.83794598
125MP0001188_hyperpigmentation0.83659645
126MP0003283_abnormal_digestive_organ0.82944861
127MP0000762_abnormal_tongue_morphology0.82802202
128MP0002295_abnormal_pulmonary_circulatio0.81468862
129MP0002928_abnormal_bile_duct0.81036866
130MP0002932_abnormal_joint_morphology0.80300787
131MP0008260_abnormal_autophagy0.79719014
132MP0005367_renal/urinary_system_phenotyp0.77437298
133MP0000516_abnormal_urinary_system0.77437298
134MP0003638_abnormal_response/metabolism_0.77343304
135MP0001756_abnormal_urination0.76846057
136MP0001765_abnormal_ion_homeostasis0.76369727
137MP0004036_abnormal_muscle_relaxation0.75874951
138MP0000566_synostosis0.75823193
139MP0004858_abnormal_nervous_system0.75384159
140MP0004085_abnormal_heartbeat0.74812209
141MP0001533_abnormal_skeleton_physiology0.74678466
142MP0002163_abnormal_gland_morphology0.74566463
143MP0001348_abnormal_lacrimal_gland0.74541665
144MP0003119_abnormal_digestive_system0.72426155
145MP0005025_abnormal_response_to0.72355083
146MP0005647_abnormal_sex_gland0.71914653
147MP0005310_abnormal_salivary_gland0.71828088
148MP0006072_abnormal_retinal_apoptosis0.71665213
149MP0003137_abnormal_impulse_conducting0.71540800
150MP0001177_atelectasis0.70041006
151MP0001502_abnormal_circadian_rhythm0.67800516
152MP0003937_abnormal_limbs/digits/tail_de0.67578713
153MP0004811_abnormal_neuron_physiology0.67401591
154MP0004133_heterotaxia0.66877165
155MP0000013_abnormal_adipose_tissue0.65835317
156MP0009780_abnormal_chondrocyte_physiolo0.65437327
157MP0002102_abnormal_ear_morphology0.65226640
158MP0009384_cardiac_valve_regurgitation0.64428477
159MP0000372_irregular_coat_pigmentation0.64260819
160MP0001984_abnormal_olfaction0.64053244
161MP0003195_calcinosis0.63482898
162MP0003806_abnormal_nucleotide_metabolis0.63396996
163MP0000749_muscle_degeneration0.63229211
164MP0005408_hypopigmentation0.62578414
165MP0000467_abnormal_esophagus_morphology0.59986165

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.59745483
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.59745483
3Neurofibrillary tangles (HP:0002185)5.85928875
4Parakeratosis (HP:0001036)5.54109338
5Cutaneous melanoma (HP:0012056)5.46316729
6Abnormality of the corticospinal tract (HP:0002492)5.00790134
7Cerebral inclusion bodies (HP:0100314)4.29202406
8Sensory axonal neuropathy (HP:0003390)4.20402397
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.01390638
10Peripheral hypomyelination (HP:0007182)4.01193041
11Abnormality of the proximal phalanges of the hand (HP:0009834)3.65925131
12Short femoral neck (HP:0100864)3.55078837
13Meningioma (HP:0002858)3.54239017
14Supranuclear gaze palsy (HP:0000605)3.48136623
15Methylmalonic aciduria (HP:0012120)3.43825119
16Spastic gait (HP:0002064)3.43429315
17Congenital, generalized hypertrichosis (HP:0004540)3.28784448
18Hypoplasia of the uterus (HP:0000013)3.28063783
19Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.27683804
20Congenital stationary night blindness (HP:0007642)3.26323188
21Scanning speech (HP:0002168)3.19139074
22Ankle clonus (HP:0011448)3.14055149
23Cerebral hypomyelination (HP:0006808)3.12427812
24Onion bulb formation (HP:0003383)3.12091868
25Myokymia (HP:0002411)3.11218815
26Increased serum pyruvate (HP:0003542)3.11095924
27Abnormality of glycolysis (HP:0004366)3.11095924
28Insidious onset (HP:0003587)3.08656124
29Termporal pattern (HP:0011008)3.08656124
30Dysmetria (HP:0001310)3.05063179
31Abolished electroretinogram (ERG) (HP:0000550)3.02801413
32Pendular nystagmus (HP:0012043)3.00799478
33Abnormality of the middle phalanges of the toes (HP:0010183)2.99510304
34Thickened helices (HP:0000391)2.99144515
35Alacrima (HP:0000522)2.97314628
36Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.94228002
37Akinesia (HP:0002304)2.92149595
38Intention tremor (HP:0002080)2.88323733
39Atonic seizures (HP:0010819)2.83594330
40Nephronophthisis (HP:0000090)2.80958289
41Congenital ichthyosiform erythroderma (HP:0007431)2.78035449
42Pancreatic cysts (HP:0001737)2.72862825
43Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.71039151
44Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.70926614
45Short 1st metacarpal (HP:0010034)2.70926614
46Focal motor seizures (HP:0011153)2.69008077
47Hyperglycinemia (HP:0002154)2.68297383
48Absent/shortened dynein arms (HP:0200106)2.67969903
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.67969903
50Hematochezia (HP:0002573)2.67355601
51Aplasia/hypoplasia of the uterus (HP:0008684)2.65757776
52Epileptic encephalopathy (HP:0200134)2.65523378
53Molar tooth sign on MRI (HP:0002419)2.64967508
54Abnormality of midbrain morphology (HP:0002418)2.64967508
55Hyperventilation (HP:0002883)2.64918450
56Leukodystrophy (HP:0002415)2.64823732
57Congenital sensorineural hearing impairment (HP:0008527)2.61219423
58True hermaphroditism (HP:0010459)2.60902093
59Abnormal auditory evoked potentials (HP:0006958)2.60496505
60Abnormality of the 1st metacarpal (HP:0010009)2.59958638
61Pancreatic fibrosis (HP:0100732)2.59248506
62Aplasia/hypoplasia of the femur (HP:0005613)2.57091189
63Short hallux (HP:0010109)2.53862576
64Retinal dysplasia (HP:0007973)2.53153381
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51898417
66Autoamputation (HP:0001218)2.50319924
67Aplasia/Hypoplasia of the hallux (HP:0008362)2.48607627
68Agitation (HP:0000713)2.47869854
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.47116058
70Abnormality of the phalanges of the 5th finger (HP:0004213)2.46391228
71Pheochromocytoma (HP:0002666)2.43082644
72Symphalangism affecting the phalanges of the hand (HP:0009773)2.42674458
73Clumsiness (HP:0002312)2.41157853
74Abnormal respiratory epithelium morphology (HP:0012253)2.36754130
75Abnormal respiratory motile cilium morphology (HP:0005938)2.36754130
76Decreased circulating renin level (HP:0003351)2.35650022
77Split foot (HP:0001839)2.34536926
78Asplenia (HP:0001746)2.30991480
79Abnormal rod and cone electroretinograms (HP:0008323)2.30797366
80Cerebral hemorrhage (HP:0001342)2.30541241
81Adactyly (HP:0009776)2.29625906
82Hypoplasia of the iris (HP:0007676)2.28661931
83Anteriorly placed anus (HP:0001545)2.27753913
84Short tibia (HP:0005736)2.27726835
85Spastic paraparesis (HP:0002313)2.26912637
86Abnormality of glycolipid metabolism (HP:0010969)2.26881308
87Abnormality of liposaccharide metabolism (HP:0010968)2.26881308
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.26881308
89Genetic anticipation (HP:0003743)2.25491101
90Hypoplastic pelvis (HP:0008839)2.24874682
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24503311
92Abnormality of the renal medulla (HP:0100957)2.23998007
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.23086388
94Decreased lacrimation (HP:0000633)2.20830159
95Humeroradial synostosis (HP:0003041)2.20576933
96Synostosis involving the elbow (HP:0003938)2.20576933
97Megalencephaly (HP:0001355)2.20394575
98IgG deficiency (HP:0004315)2.19672213
99Lower limb muscle weakness (HP:0007340)2.19211748
100Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18989739
101Slow saccadic eye movements (HP:0000514)2.18943138
102Neuroendocrine neoplasm (HP:0100634)2.18535146
103Stridor (HP:0010307)2.17634718
104Vacuolated lymphocytes (HP:0001922)2.16706363
105Conjunctival hamartoma (HP:0100780)2.16332179
106Stenosis of the external auditory canal (HP:0000402)2.15341234
107Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.14659925
108Segmental peripheral demyelination/remyelination (HP:0003481)2.14650281
109Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14319603
110Abnormal respiratory motile cilium physiology (HP:0012261)2.12821490
111Bone cyst (HP:0012062)2.11673848
112Abnormal ciliary motility (HP:0012262)2.11055209
113Visual hallucinations (HP:0002367)2.10023349
114Methylmalonic acidemia (HP:0002912)2.08963931
115Aplasia involving bones of the upper limbs (HP:0009823)2.08491561
116Aplasia of the phalanges of the hand (HP:0009802)2.08491561
117Aplasia involving bones of the extremities (HP:0009825)2.08491561
118Muscle fiber splitting (HP:0003555)2.08478042
119Morphological abnormality of the inner ear (HP:0011390)2.06281143
120Abnormal drinking behavior (HP:0030082)2.05987437
121Polydipsia (HP:0001959)2.05987437
122Absent septum pellucidum (HP:0001331)2.05623632
123Progressive cerebellar ataxia (HP:0002073)2.04841689
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04074866
125Dysostosis multiplex (HP:0000943)2.04071046
126Broad-based gait (HP:0002136)2.01915687
127Prostate neoplasm (HP:0100787)2.01067257
128Gaze-evoked nystagmus (HP:0000640)2.00848855
129Diplopia (HP:0000651)1.99023134
130Abnormality of binocular vision (HP:0011514)1.99023134
131Partial agenesis of the corpus callosum (HP:0001338)1.98878257
132Poor speech (HP:0002465)1.98106028
133Mitochondrial inheritance (HP:0001427)1.97802728
134Erythroderma (HP:0001019)1.97466242
135Spastic tetraparesis (HP:0001285)1.96119037
136Cystic liver disease (HP:0006706)1.96097634
137Cupped ear (HP:0000378)1.95135649
138Foot dorsiflexor weakness (HP:0009027)1.92973492
139Increased circulating renin level (HP:0000848)1.92703054
140Paralysis (HP:0003470)1.90041818
141White forelock (HP:0002211)1.89725470
142CNS hypomyelination (HP:0003429)1.88870197
143Hypoplasia of the ulna (HP:0003022)1.88210696
144Metabolic alkalosis (HP:0200114)1.88133967
145Progressive inability to walk (HP:0002505)1.86443884
146Keratoconus (HP:0000563)1.85905330
147Increased corneal curvature (HP:0100692)1.85905330
148Chorioretinal atrophy (HP:0000533)1.85244143
149Patchy hypopigmentation of hair (HP:0011365)1.85226536
150Type II lissencephaly (HP:0007260)1.84457928
151Focal seizures (HP:0007359)1.84120782
152Morphological abnormality of the pyramidal tract (HP:0002062)1.84027488
153Furrowed tongue (HP:0000221)1.83905163
1543-Methylglutaconic aciduria (HP:0003535)1.83346377
155Short phalanx of the thumb (HP:0009660)1.83085415
156Porencephaly (HP:0002132)1.82370794
157Premature skin wrinkling (HP:0100678)1.81581543
158Vaginal atresia (HP:0000148)1.81512060
159Abnormality of the nasal septum (HP:0000419)1.81246865
160Hemiparesis (HP:0001269)1.80089199
161Limb dystonia (HP:0002451)1.80051409
162Generalized myoclonic seizures (HP:0002123)1.79786030
163Acute necrotizing encephalopathy (HP:0006965)1.79701996
164Barrel-shaped chest (HP:0001552)1.79518416
165Thyroiditis (HP:0100646)1.79423341
166Progressive macrocephaly (HP:0004481)1.78409879
167Decreased central vision (HP:0007663)1.78033991
168Bowel incontinence (HP:0002607)1.77937862
169Hypoplastic left heart (HP:0004383)1.77639181
170Absent thumb (HP:0009777)1.77610935
171Widely spaced teeth (HP:0000687)1.77526726
172Attenuation of retinal blood vessels (HP:0007843)1.77169149
173Clonus (HP:0002169)1.76996831
174Abnormality of the septum pellucidum (HP:0007375)1.76538101
175Urinary urgency (HP:0000012)1.75905803
176Hypomagnesemia (HP:0002917)1.75895243
177Fused cervical vertebrae (HP:0002949)1.75341575
178Oligodontia (HP:0000677)1.74557569
179Medial flaring of the eyebrow (HP:0010747)1.73902558
180Abnormality of the fetal cardiovascular system (HP:0010948)1.73133673
181Abnormal umbilical cord blood vessels (HP:0011403)1.73133673
182Single umbilical artery (HP:0001195)1.73133673
183Mixed hearing impairment (HP:0000410)1.72385634
184Fibular aplasia (HP:0002990)1.72360049
185Morphological abnormality of the middle ear (HP:0008609)1.72126246
186Hyporeflexia of lower limbs (HP:0002600)1.71938155
187Genital tract atresia (HP:0001827)1.71896852
188Dicarboxylic aciduria (HP:0003215)1.71794528
189Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71794528
190Abnormality of the renal collecting system (HP:0004742)1.71683750
191Abnormality of the renal cortex (HP:0011035)1.71582924
192Abnormality of the foot musculature (HP:0001436)1.70900002
193Carpal bone hypoplasia (HP:0001498)1.70103905
194Coronal craniosynostosis (HP:0004440)1.68198154
195Dysdiadochokinesis (HP:0002075)1.67472092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.67277570
2FRK5.29269344
3OXSR14.50471188
4EPHB13.17859253
5CDK193.08428746
6BCR3.01133917
7TAOK32.70348659
8TLK12.52372379
9CASK2.49375833
10TXK2.37265406
11PRPF4B2.35284830
12WNK42.27199085
13PKN12.22571523
14LIMK12.05270276
15ACVR1B2.03622774
16PNCK1.99487064
17BCKDK1.99280695
18IKBKB1.98957839
19MET1.96600580
20MAPKAPK51.86843393
21TNIK1.83226728
22WNK11.80595863
23PBK1.79198032
24CSNK1G31.76451455
25CSNK1A1L1.70391663
26ICK1.63110321
27CAMK2B1.56638386
28ROCK21.50006003
29NEK61.49278424
30FGFR21.46220108
31MAP3K111.46163584
32NTRK11.43832155
33MAP3K141.41854414
34NME21.41749049
35CSNK1G11.41536408
36BLK1.41396655
37MAP4K21.40272336
38TGFBR21.39642172
39CSNK1G21.38978123
40UHMK11.38556418
41MST41.38509663
42FGR1.37818796
43EPHA41.35428528
44MARK11.35003552
45EPHB21.34544227
46ZAK1.33943161
47PAK61.33022628
48TESK21.29363554
49CAMK2D1.28234787
50SGK4941.23434574
51SGK2231.23434574
52TIE11.22022553
53ABL21.19284286
54DAPK21.15819138
55ARAF1.15516390
56MST1R1.15023846
57PRKD21.13300515
58INSRR1.12848797
59BMPR1B1.12300766
60EPHA21.10180299
61MAP3K131.05403648
62NUAK11.04942837
63PAK31.03747557
64ADRBK11.03688136
65MAPK151.02807443
66CHUK1.01136661
67CAMKK21.00934459
68MATK0.98956539
69TBK10.96165730
70CAMK2G0.95611102
71CAMK2A0.94986971
72CDK50.93908516
73PHKG10.93839249
74PHKG20.93839249
75GRK50.93673733
76PIM20.93526898
77TRPM70.92107555
78PRKCE0.89777056
79DYRK20.88290826
80CDK140.88120045
81MAP3K90.84917061
82IKBKE0.84569530
83MAPKAPK30.82757531
84RPS6KA60.80351889
85PRKCQ0.79512909
86KIT0.78965419
87CSK0.77864826
88IRAK30.77849388
89NTRK20.77180728
90MAP4K10.75703035
91CSF1R0.75248820
92CDK150.74181671
93SYK0.73288773
94CDK180.70908053
95CLK10.70727637
96DYRK30.68074569
97PDPK10.67677036
98ERBB40.66994668
99LYN0.66484220
100GRK70.65538018
101CDK11A0.64597000
102MUSK0.63343088
103MARK20.62504060
104TGFBR10.61870299
105TYRO30.61748516
106RPS6KA20.61566110
107PRKD30.61419092
108MAP3K40.60827827
109MAP2K20.58765654
110KSR20.58040892
111NTRK30.56757881
112CDK90.56401752
113PRKD10.55346326
114RPS6KL10.54729705
115RPS6KC10.54729705
116MAP2K60.53692820
117FYN0.53117977
118SGK20.51103918
119LCK0.49778513
120MAPK70.47824622
121PLK20.47595568
122PRKG10.46563296
123STK160.45915726
124GRK10.45565218
125STK110.43923385
126ABL10.43645447
127CSNK1D0.43544414
128PINK10.43440319
129ITK0.43025866
130CAMK1G0.42432808
131TEC0.41344778
132PIK3CA0.41291795
133NME10.41135940
134DDR20.40872035
135PRKACB0.40698405
136PRKCA0.39987799
137IGF1R0.38861280
138PRKCH0.37871369
139CDK80.37779604
140CSNK1A10.37741248
141ADRBK20.37120397
142PTK2B0.36177377
143MAPK130.35475514
144PDK10.32799658
145MAP2K70.32432978
146DAPK30.32270354
147DYRK1A0.31802843
148RPS6KA50.31005995
149PRKCG0.30733366
150BRAF0.29406732
151BMX0.29071704
152PRKACA0.27303983
153WNK30.25578692
154SGK10.25441752
155MOS0.25060840
156GSK3A0.23609748

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.31779034
2Fatty acid elongation_Homo sapiens_hsa000624.12188746
3Steroid biosynthesis_Homo sapiens_hsa001003.41221909
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03438832
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.97918735
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68256279
7Ether lipid metabolism_Homo sapiens_hsa005652.64600468
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.64053299
9Oxidative phosphorylation_Homo sapiens_hsa001902.46669201
10Asthma_Homo sapiens_hsa053102.37667389
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24977669
12Axon guidance_Homo sapiens_hsa043601.98885814
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88679269
14Sulfur metabolism_Homo sapiens_hsa009201.85192265
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84412899
16Parkinsons disease_Homo sapiens_hsa050121.71468161
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71467139
18Protein export_Homo sapiens_hsa030601.71105526
19Sphingolipid metabolism_Homo sapiens_hsa006001.71067606
20Alzheimers disease_Homo sapiens_hsa050101.69426792
21GABAergic synapse_Homo sapiens_hsa047271.66652875
22Allograft rejection_Homo sapiens_hsa053301.66517694
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.63259971
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62741087
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.59139069
26Graft-versus-host disease_Homo sapiens_hsa053321.58873203
27Collecting duct acid secretion_Homo sapiens_hsa049661.57557923
28Nicotine addiction_Homo sapiens_hsa050331.57490737
29Glutamatergic synapse_Homo sapiens_hsa047241.52766539
30Primary immunodeficiency_Homo sapiens_hsa053401.52202658
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51719316
32Serotonergic synapse_Homo sapiens_hsa047261.47536658
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.45151460
34Morphine addiction_Homo sapiens_hsa050321.44134953
35Vibrio cholerae infection_Homo sapiens_hsa051101.44112166
36Tryptophan metabolism_Homo sapiens_hsa003801.35399567
37Chemical carcinogenesis_Homo sapiens_hsa052041.35008944
38Butanoate metabolism_Homo sapiens_hsa006501.33619350
39Synaptic vesicle cycle_Homo sapiens_hsa047211.30941544
40Type I diabetes mellitus_Homo sapiens_hsa049401.27485185
41Retinol metabolism_Homo sapiens_hsa008301.26805456
42Renal cell carcinoma_Homo sapiens_hsa052111.24338493
43Vitamin B6 metabolism_Homo sapiens_hsa007501.24126116
44Long-term depression_Homo sapiens_hsa047301.23020390
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19386493
46Cardiac muscle contraction_Homo sapiens_hsa042601.16366985
47Circadian entrainment_Homo sapiens_hsa047131.16345792
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15009415
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.14770561
50Sulfur relay system_Homo sapiens_hsa041221.12173945
51Rheumatoid arthritis_Homo sapiens_hsa053231.10039810
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09139073
53Hematopoietic cell lineage_Homo sapiens_hsa046401.08343679
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08231313
55Tight junction_Homo sapiens_hsa045301.07864312
56Antigen processing and presentation_Homo sapiens_hsa046121.07300398
57Histidine metabolism_Homo sapiens_hsa003401.06264478
58Salivary secretion_Homo sapiens_hsa049701.03156802
59Linoleic acid metabolism_Homo sapiens_hsa005911.02120602
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02047558
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97759246
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97166595
63Staphylococcus aureus infection_Homo sapiens_hsa051500.96239359
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95966057
65Peroxisome_Homo sapiens_hsa041460.95276387
66Glycerolipid metabolism_Homo sapiens_hsa005610.94996606
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94868860
68Huntingtons disease_Homo sapiens_hsa050160.94428264
69Gastric acid secretion_Homo sapiens_hsa049710.92183260
70Taste transduction_Homo sapiens_hsa047420.89524169
71Dopaminergic synapse_Homo sapiens_hsa047280.89242754
72Nitrogen metabolism_Homo sapiens_hsa009100.88458776
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86941449
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.86030134
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85766792
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85330661
77Cocaine addiction_Homo sapiens_hsa050300.84733008
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83734275
79Type II diabetes mellitus_Homo sapiens_hsa049300.83067331
80Arginine and proline metabolism_Homo sapiens_hsa003300.82894656
81Endocytosis_Homo sapiens_hsa041440.80467362
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.79626974
83Ras signaling pathway_Homo sapiens_hsa040140.79249039
84Fatty acid biosynthesis_Homo sapiens_hsa000610.79166742
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79121630
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78774730
87Amphetamine addiction_Homo sapiens_hsa050310.74497444
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73476921
89Caffeine metabolism_Homo sapiens_hsa002320.73288393
90Cholinergic synapse_Homo sapiens_hsa047250.72720694
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71279051
92ECM-receptor interaction_Homo sapiens_hsa045120.70414522
93Long-term potentiation_Homo sapiens_hsa047200.70057046
94Renin secretion_Homo sapiens_hsa049240.69344693
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.69225433
96Phototransduction_Homo sapiens_hsa047440.69122456
97Vitamin digestion and absorption_Homo sapiens_hsa049770.68999672
98Other glycan degradation_Homo sapiens_hsa005110.68992911
99Autoimmune thyroid disease_Homo sapiens_hsa053200.68354446
100ErbB signaling pathway_Homo sapiens_hsa040120.67951442
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.67620388
102Ovarian steroidogenesis_Homo sapiens_hsa049130.65586613
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64995268
104Olfactory transduction_Homo sapiens_hsa047400.64417813
105Renin-angiotensin system_Homo sapiens_hsa046140.63215302
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61125697
107Glutathione metabolism_Homo sapiens_hsa004800.61075962
108Propanoate metabolism_Homo sapiens_hsa006400.60869445
109cAMP signaling pathway_Homo sapiens_hsa040240.60778990
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60223596
111African trypanosomiasis_Homo sapiens_hsa051430.59714254
112Phagosome_Homo sapiens_hsa041450.58552989
113Mineral absorption_Homo sapiens_hsa049780.57698002
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.57066917
115Pancreatic secretion_Homo sapiens_hsa049720.55860403
116Gap junction_Homo sapiens_hsa045400.55331357
117Arachidonic acid metabolism_Homo sapiens_hsa005900.55285512
118Calcium signaling pathway_Homo sapiens_hsa040200.54419917
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.53958405
120Fatty acid metabolism_Homo sapiens_hsa012120.52898871
121Hedgehog signaling pathway_Homo sapiens_hsa043400.52397735
122Insulin secretion_Homo sapiens_hsa049110.52010257
123Dorso-ventral axis formation_Homo sapiens_hsa043200.50514910
124Dilated cardiomyopathy_Homo sapiens_hsa054140.50375124
125Basal transcription factors_Homo sapiens_hsa030220.49974877
126Fanconi anemia pathway_Homo sapiens_hsa034600.49508141
127Osteoclast differentiation_Homo sapiens_hsa043800.49320856
128Oxytocin signaling pathway_Homo sapiens_hsa049210.47614899
129TNF signaling pathway_Homo sapiens_hsa046680.47469373
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47312926
131Prion diseases_Homo sapiens_hsa050200.47038871
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.47033177
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46995025
134Malaria_Homo sapiens_hsa051440.46718659
135Melanogenesis_Homo sapiens_hsa049160.45518104
136Selenocompound metabolism_Homo sapiens_hsa004500.45284818
137Systemic lupus erythematosus_Homo sapiens_hsa053220.44237340
138Lysosome_Homo sapiens_hsa041420.43737517
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43266548
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41929509
141MAPK signaling pathway_Homo sapiens_hsa040100.41712918
142RNA polymerase_Homo sapiens_hsa030200.40847303
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40317568
144Leishmaniasis_Homo sapiens_hsa051400.40284224
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39534156
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39041074
147RNA degradation_Homo sapiens_hsa030180.38784511
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38031071
149Choline metabolism in cancer_Homo sapiens_hsa052310.37807419
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37228684
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36809328
152Wnt signaling pathway_Homo sapiens_hsa043100.35192521

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