HS3ST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide catabolic process (GO:0009313)7.12735424
2glycosphingolipid catabolic process (GO:0046479)6.95279142
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.45588728
4synaptic vesicle exocytosis (GO:0016079)6.38309691
5synaptic vesicle maturation (GO:0016188)6.35980783
6glutamate secretion (GO:0014047)6.31318568
7glycolipid catabolic process (GO:0019377)6.24326282
8amino sugar catabolic process (GO:0046348)5.83664644
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.76657554
10regulation of synaptic vesicle exocytosis (GO:2000300)5.74346879
11ceramide catabolic process (GO:0046514)5.68272604
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56423625
13locomotory exploration behavior (GO:0035641)5.44730041
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.35775239
15vocalization behavior (GO:0071625)5.27370851
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21316858
17neuronal action potential propagation (GO:0019227)5.10106756
18protein localization to synapse (GO:0035418)5.09936458
19regulation of synaptic vesicle transport (GO:1902803)5.02974954
20cellular response to thyroid hormone stimulus (GO:0097067)4.87675568
21regulation of glutamate receptor signaling pathway (GO:1900449)4.76561326
22neuron cell-cell adhesion (GO:0007158)4.73118591
23layer formation in cerebral cortex (GO:0021819)4.64190991
24positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.62804491
25exploration behavior (GO:0035640)4.53354595
26neurotransmitter secretion (GO:0007269)4.51969452
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39838792
28regulation of neuronal synaptic plasticity (GO:0048168)4.31947124
29ganglioside metabolic process (GO:0001573)4.29846783
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.22873320
31regulation of cholesterol storage (GO:0010885)4.22445914
32sphingolipid catabolic process (GO:0030149)4.19952152
33regulation of mononuclear cell migration (GO:0071675)4.19377910
34regulation of synapse structural plasticity (GO:0051823)4.18236942
35proline transport (GO:0015824)4.17375983
36membrane lipid catabolic process (GO:0046466)4.11104984
37synaptic transmission, glutamatergic (GO:0035249)4.07776542
38negative regulation of nitric oxide biosynthetic process (GO:0045019)4.03660939
39neuron-neuron synaptic transmission (GO:0007270)4.00213006
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98042628
41negative regulation of interleukin-12 production (GO:0032695)3.96744546
42dendritic spine morphogenesis (GO:0060997)3.95787004
43glutamate receptor signaling pathway (GO:0007215)3.92543965
44response to acidic pH (GO:0010447)3.87875842
45neurotransmitter-gated ion channel clustering (GO:0072578)3.87386768
46synaptic vesicle endocytosis (GO:0048488)3.85418876
47neuron recognition (GO:0008038)3.83138645
48glucosamine-containing compound catabolic process (GO:1901072)3.79152031
49regulation of neurotransmitter secretion (GO:0046928)3.78542318
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78412862
51positive regulation of membrane potential (GO:0045838)3.71429876
52positive regulation of neurotransmitter secretion (GO:0001956)3.70306846
53transferrin transport (GO:0033572)3.68898800
54phagosome maturation (GO:0090382)3.67437728
55activation of protein kinase A activity (GO:0034199)3.66240350
56keratan sulfate catabolic process (GO:0042340)3.65961969
57response to thyroid hormone (GO:0097066)3.65151590
58regulation of synaptic plasticity (GO:0048167)3.62117387
59regulation of dendritic spine morphogenesis (GO:0061001)3.61147005
60regulation of postsynaptic membrane potential (GO:0060078)3.60820282
61axonal fasciculation (GO:0007413)3.59079612
62neurotransmitter transport (GO:0006836)3.58950818
63long-term synaptic potentiation (GO:0060291)3.58739262
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.57943321
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57855313
66neutrophil activation involved in immune response (GO:0002283)3.57431603
67positive regulation of leukocyte degranulation (GO:0043302)3.55863325
68positive regulation of monocyte chemotaxis (GO:0090026)3.54092294
69positive regulation of mast cell activation involved in immune response (GO:0033008)3.53804752
70positive regulation of mast cell degranulation (GO:0043306)3.53804752
71gamma-aminobutyric acid transport (GO:0015812)3.52583073
72regulation of vesicle fusion (GO:0031338)3.52251280
73negative regulation of dendrite morphogenesis (GO:0050774)3.52048996
74N-acetylneuraminate metabolic process (GO:0006054)3.50773934
75long-term memory (GO:0007616)3.42951086
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42538948
77trivalent inorganic cation transport (GO:0072512)3.42237954
78ferric iron transport (GO:0015682)3.42237954
79positive regulation of neurotransmitter transport (GO:0051590)3.39949228
80intracellular pH reduction (GO:0051452)3.38286579
81response to peptidoglycan (GO:0032494)3.37955489
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37705512
83regulation of neurotransmitter transport (GO:0051588)3.37379949
84cellular potassium ion homeostasis (GO:0030007)3.37078064
85postsynaptic membrane organization (GO:0001941)3.35731882
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35631109
87positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.33494864
88pH reduction (GO:0045851)3.31109577
89regulation of neurotransmitter levels (GO:0001505)3.30358481
90presynaptic membrane assembly (GO:0097105)3.28110612
91cell migration in hindbrain (GO:0021535)3.27021321
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27012148
93negative regulation of dendrite development (GO:2000171)3.26800477
94regulation of dendritic spine development (GO:0060998)3.24420618
95ATP hydrolysis coupled proton transport (GO:0015991)3.24247474
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.24247474
97regulation of voltage-gated calcium channel activity (GO:1901385)3.24143367
98fat-soluble vitamin biosynthetic process (GO:0042362)3.23836909
99regulation of synaptic transmission, glutamatergic (GO:0051966)3.21870885
100osteoclast differentiation (GO:0030316)3.21498776
101response to magnesium ion (GO:0032026)3.21283939
102neuromuscular process controlling balance (GO:0050885)3.21060576
103response to lipoprotein particle (GO:0055094)3.19677300
104positive regulation of synapse maturation (GO:0090129)3.18304585
105positive regulation of bone resorption (GO:0045780)3.16565949
106positive regulation of bone remodeling (GO:0046852)3.16565949
107vesicle transport along microtubule (GO:0047496)3.15033471
108cerebellar Purkinje cell differentiation (GO:0021702)3.12733592
109regulation of vitamin D biosynthetic process (GO:0060556)3.11437004
110membrane depolarization (GO:0051899)3.10451568
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10067380
112lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07950387
113dendrite morphogenesis (GO:0048813)3.07186757
114regulation of glutamate secretion (GO:0014048)3.07044282
115positive regulation of mast cell activation (GO:0033005)3.06739143
116presynaptic membrane organization (GO:0097090)3.06137764
117macrophage activation involved in immune response (GO:0002281)3.04921938
118peptide catabolic process (GO:0043171)3.04904202
119organelle transport along microtubule (GO:0072384)3.04117444
120establishment of synaptic vesicle localization (GO:0097480)3.04012430
121synaptic vesicle transport (GO:0048489)3.04012430
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03388075
123apoptotic cell clearance (GO:0043277)3.01855665
124monocyte chemotaxis (GO:0002548)3.01267416
125innervation (GO:0060384)2.99866922
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.99861267
127regulation of synaptic transmission (GO:0050804)2.99312289
128synaptic transmission (GO:0007268)2.99013391
129membrane depolarization during action potential (GO:0086010)2.98148469
130transmission of nerve impulse (GO:0019226)2.97771858
131negative regulation of microtubule polymerization (GO:0031115)2.97371809
132myeloid dendritic cell differentiation (GO:0043011)2.96763088
133synapse assembly (GO:0007416)2.96477793
134positive regulation of dendritic spine development (GO:0060999)2.96434937
135response to histamine (GO:0034776)2.95583778
136behavioral response to cocaine (GO:0048148)2.95478278
137positive regulation of synaptic transmission (GO:0050806)2.94808077
138positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94596029
139detection of calcium ion (GO:0005513)2.92591281
140response to auditory stimulus (GO:0010996)2.91367796
141negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.90912470
142bone resorption (GO:0045453)2.89335005
143calcium ion-dependent exocytosis (GO:0017156)2.88896780
144sodium ion export (GO:0071436)2.88886436
145regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88856217
146iron ion transport (GO:0006826)2.87456012
147dendritic spine organization (GO:0097061)2.87128404
148positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86397094
149membrane hyperpolarization (GO:0060081)2.86160518
150cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85518927
151social behavior (GO:0035176)2.85202617
152intraspecies interaction between organisms (GO:0051703)2.85202617
153positive regulation of cholesterol efflux (GO:0010875)2.84666777
154lysosome organization (GO:0007040)2.82196534
155lytic vacuole organization (GO:0080171)2.82196534
156iron ion import (GO:0097286)2.81905235
157negative regulation of lipid storage (GO:0010888)2.81217063
158adhesion of symbiont to host cell (GO:0044650)2.79983094
159virion attachment to host cell (GO:0019062)2.79983094
160negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79228692
161positive regulation of osteoclast differentiation (GO:0045672)2.77549377
162vitamin D metabolic process (GO:0042359)2.77438991
163regulation of mast cell degranulation (GO:0043304)2.73647188
164barbed-end actin filament capping (GO:0051016)2.70604302
165regulation of monocyte differentiation (GO:0045655)2.70434549
166immunoglobulin mediated immune response (GO:0016064)2.69972583
167regulation of monocyte chemotaxis (GO:0090025)2.69327568
168negative regulation of amino acid transport (GO:0051956)2.69120448
169granulocyte activation (GO:0036230)2.67549832
170cellular extravasation (GO:0045123)2.66056088
171cellular response to arsenic-containing substance (GO:0071243)2.65623888
172regulation of leukocyte degranulation (GO:0043300)2.64243746
173positive regulation of heat generation (GO:0031652)2.63123430
174regulation of hydrogen peroxide-induced cell death (GO:1903205)2.62618724
175negative regulation of interleukin-1 beta production (GO:0032691)2.61804481
176lipid storage (GO:0019915)2.60755610
177negative regulation of response to reactive oxygen species (GO:1901032)2.60258528
178positive regulation of chemokine biosynthetic process (GO:0045080)2.59672593
179cellular iron ion homeostasis (GO:0006879)2.58098989
180glycosphingolipid metabolic process (GO:0006687)2.58027695
181positive regulation of tissue remodeling (GO:0034105)2.55616578
182L-amino acid import (GO:0043092)2.54040720
183regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53506884
184T-helper 1 type immune response (GO:0042088)2.51636238
185regulation of mast cell activation involved in immune response (GO:0033006)2.51594762
186adhesion of symbiont to host (GO:0044406)2.50881942
187regulation of macrophage chemotaxis (GO:0010758)2.49600419
188protein localization to endosome (GO:0036010)2.48447005
189sphingosine metabolic process (GO:0006670)2.47878212
190myeloid dendritic cell activation (GO:0001773)2.47114333
191regulation of superoxide anion generation (GO:0032928)2.46727877
192positive regulation of cholesterol transport (GO:0032376)2.46025052
193positive regulation of sterol transport (GO:0032373)2.46025052
194neuromuscular process controlling posture (GO:0050884)2.43694209
195fructose metabolic process (GO:0006000)2.42339178
196positive regulation of regulated secretory pathway (GO:1903307)2.39257638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41587366
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.58574497
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.78142729
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.57957306
5GBX2_23144817_ChIP-Seq_PC3_Human3.53582693
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.52969281
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.32182689
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25107819
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.16720943
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15717573
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10564434
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.06435624
13VDR_24787735_ChIP-Seq_THP-1_Human2.85966962
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84840873
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84840873
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.80206263
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72962304
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72241606
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64194797
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61261995
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.59293251
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59168993
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57697975
24* EZH2_27304074_Chip-Seq_ESCs_Mouse2.57532671
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56084163
26DROSHA_22980978_ChIP-Seq_HELA_Human2.39015019
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.33212606
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32302237
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.28386184
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.24083358
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.22774412
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21740966
33AR_21572438_ChIP-Seq_LNCaP_Human2.21557726
34TAF15_26573619_Chip-Seq_HEK293_Human2.18348177
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18029944
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12446702
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11505351
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02366063
39* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91618978
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90655504
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87757685
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86533930
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85844124
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75713685
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75682975
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75458510
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74757572
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74564410
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.74080723
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73167348
51SPI1_23127762_ChIP-Seq_K562_Human1.65587024
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.64863431
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62697034
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56768160
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.55827781
56GATA1_22025678_ChIP-Seq_K562_Human1.53074180
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52167420
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52118683
59P300_19829295_ChIP-Seq_ESCs_Human1.45758539
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45587398
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.45363017
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.42883471
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41615398
64VDR_24763502_ChIP-Seq_THP-1_Human1.41460019
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39631051
66* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39474705
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39271192
68ZNF274_21170338_ChIP-Seq_K562_Hela1.39010440
69* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38996238
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38353685
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37931182
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.36690854
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35885689
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35343913
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33798038
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32692289
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31733025
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31492128
79PU_27001747_Chip-Seq_BMDM_Mouse1.30948422
80* SMAD3_21741376_ChIP-Seq_EPCs_Human1.30375386
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.29829113
82IGF1R_20145208_ChIP-Seq_DFB_Human1.29579418
83AR_25329375_ChIP-Seq_VCAP_Human1.29025423
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28724469
85* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27444576
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.27146035
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26354954
88STAT1_20625510_ChIP-Seq_HELA_Human1.25128167
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24613321
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24474102
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23020675
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22318744
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.20435121
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20307864
95RNF2_27304074_Chip-Seq_NSC_Mouse1.16377262
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16351896
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16308629
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16066956
99AR_19668381_ChIP-Seq_PC3_Human1.15959003
100SCL_19346495_ChIP-Seq_HPC-7_Human1.15641255
101STAT3_23295773_ChIP-Seq_U87_Human1.15377154
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14900011
103* LXR_22292898_ChIP-Seq_THP-1_Human1.14209774
104TFEB_21752829_ChIP-Seq_HELA_Human1.14023977
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.12630156
106FUS_26573619_Chip-Seq_HEK293_Human1.11657762
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11089228
108* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10617933
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09724530
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09035659
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.08990446
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08670759
113TCF4_23295773_ChIP-Seq_U87_Human1.08485848
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08349773
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08184599
116GATA1_19941826_ChIP-Seq_K562_Human1.07532178
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07083643
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.06844919
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06576426
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05922163
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05781112
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03617099
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.02976494
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01708486
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00153157
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00104548
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99954297
128RUNX2_22187159_ChIP-Seq_PCA_Human0.99709028
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99515916
130KDM2B_26808549_Chip-Seq_K562_Human0.99334269
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.99282142
132* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98845851
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98634790
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97810414
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97305691
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96967599
137* MITF_21258399_ChIP-Seq_MELANOMA_Human0.95820188
138TP53_16413492_ChIP-PET_HCT116_Human0.95735495
139JUN_21703547_ChIP-Seq_K562_Human0.95575115
140AHR_22903824_ChIP-Seq_MCF-7_Human0.95318974
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94530411
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93626282
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93500234
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93042549
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92430067
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91862714
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91862714
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91578097
149VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90420375
150ESR1_21235772_ChIP-Seq_MCF-7_Human0.90362934
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90352603
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88033357
153* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86417874
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86300308
155ER_23166858_ChIP-Seq_MCF-7_Human0.86246780
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86135889
157SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86089667
158BCAT_22108803_ChIP-Seq_LS180_Human0.86021743
159TP53_18474530_ChIP-ChIP_U2OS_Human0.85932065
160SPI1_23547873_ChIP-Seq_NB4_Human0.85259889
161* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85182356
162* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85168881
163TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84996134
164SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84871761
165JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84413033
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82264896
167* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81934556
168LXR_22158963_ChIP-Seq_LIVER_Mouse0.80460283
169RUNX1_22412390_ChIP-Seq_EML_Mouse0.75376649
170RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74136411
171NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.72752575
172JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72211502
173NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71623034
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71623034
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71506268
176GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70909840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.71839547
2MP0005058_abnormal_lysosome_morphology5.17020404
3MP0003880_abnormal_central_pattern4.86350995
4MP0003172_abnormal_lysosome_physiology4.62835898
5MP0009840_abnormal_foam_cell4.37189786
6MP0003635_abnormal_synaptic_transmissio4.30653687
7MP0004270_analgesia4.19792359
8MP0001968_abnormal_touch/_nociception3.58748328
9MP0002063_abnormal_learning/memory/cond3.46862429
10MP0009745_abnormal_behavioral_response3.42167657
11MP0003303_peritoneal_inflammation3.31607632
12MP0006082_CNS_inflammation3.28494981
13MP0002064_seizures3.25953358
14MP0009046_muscle_twitch3.13645796
15MP0002734_abnormal_mechanical_nocicepti2.99645712
16MP0002736_abnormal_nociception_after2.95879712
17MP0002572_abnormal_emotion/affect_behav2.87898780
18MP0005423_abnormal_somatic_nervous2.74598801
19MP0002139_abnormal_hepatobiliary_system2.71065995
20MP0001486_abnormal_startle_reflex2.70445344
21MP0002148_abnormal_hypersensitivity_rea2.64429168
22MP0003724_increased_susceptibility_to2.59660887
23MP0002272_abnormal_nervous_system2.52325626
24MP0003191_abnormal_cellular_cholesterol2.51585114
25MP0002735_abnormal_chemical_nociception2.37372354
26MP0002733_abnormal_thermal_nociception2.36960902
27MP0000343_altered_response_to2.27745746
28MP0001440_abnormal_grooming_behavior2.21977976
29MP0002419_abnormal_innate_immunity2.19855997
30MP0001970_abnormal_pain_threshold2.19078792
31MP0003436_decreased_susceptibility_to2.18007526
32MP0004858_abnormal_nervous_system2.09321865
33MP0003329_amyloid_beta_deposits2.06872347
34MP0005671_abnormal_response_to2.03507206
35MP0002067_abnormal_sensory_capabilities2.02449885
36MP0001501_abnormal_sleep_pattern2.01717588
37MP0005257_abnormal_intraocular_pressure1.97348476
38MP0009780_abnormal_chondrocyte_physiolo1.93724286
39MP0000778_abnormal_nervous_system1.92831254
40MP0004811_abnormal_neuron_physiology1.91916934
41MP0001835_abnormal_antigen_presentation1.87852275
42MP0005310_abnormal_salivary_gland1.87258628
43MP0002822_catalepsy1.84947502
44MP0002184_abnormal_innervation1.84388177
45MP0004924_abnormal_behavior1.79635802
46MP0005386_behavior/neurological_phenoty1.79635802
47MP0008569_lethality_at_weaning1.79376347
48MP0003879_abnormal_hair_cell1.78550602
49MP0002557_abnormal_social/conspecific_i1.74662224
50MP0005000_abnormal_immune_tolerance1.71149161
51MP0002998_abnormal_bone_remodeling1.68147094
52MP0005167_abnormal_blood-brain_barrier1.67510768
53MP0006276_abnormal_autonomic_nervous1.66311293
54MP0000955_abnormal_spinal_cord1.64638496
55MP0009764_decreased_sensitivity_to1.64349604
56MP0002909_abnormal_adrenal_gland1.55359645
57MP0005451_abnormal_body_composition1.54910746
58MP0009785_altered_susceptibility_to1.54783011
59MP0002452_abnormal_antigen_presenting1.52564883
60MP0005025_abnormal_response_to1.51498059
61MP0001984_abnormal_olfaction1.47771725
62MP0003300_gastrointestinal_ulcer1.47564345
63MP0002066_abnormal_motor_capabilities/c1.47369322
64MP0002882_abnormal_neuron_morphology1.43659675
65MP0001533_abnormal_skeleton_physiology1.40080837
66MP0001790_abnormal_immune_system1.39286618
67MP0005387_immune_system_phenotype1.39286618
68MP0001905_abnormal_dopamine_level1.38530250
69MP0003787_abnormal_imprinting1.35275199
70MP0003633_abnormal_nervous_system1.34216161
71MP0002723_abnormal_immune_serum1.29908526
72MP0005365_abnormal_bile_salt1.29032756
73MP0003656_abnormal_erythrocyte_physiolo1.26164517
74MP0005646_abnormal_pituitary_gland1.25337229
75MP0004142_abnormal_muscle_tone1.23738188
76MP0001845_abnormal_inflammatory_respons1.18884460
77MP0003631_nervous_system_phenotype1.18001185
78MP0005645_abnormal_hypothalamus_physiol1.17343181
79MP0001853_heart_inflammation1.15714350
80MP0001529_abnormal_vocalization1.15576628
81MP0001502_abnormal_circadian_rhythm1.15450228
82MP0000751_myopathy1.15360640
83MP0005166_decreased_susceptibility_to1.14800296
84MP0003448_altered_tumor_morphology1.12391241
85MP0002152_abnormal_brain_morphology1.10664148
86MP0003806_abnormal_nucleotide_metabolis1.08151823
87MP0005647_abnormal_sex_gland1.07773910
88MP0005410_abnormal_fertilization1.04923243
89MP0004885_abnormal_endolymph1.04482372
90MP0008872_abnormal_physiological_respon1.04471740
91MP0002420_abnormal_adaptive_immunity1.04209964
92MP0001800_abnormal_humoral_immune1.03654719
93MP0008874_decreased_physiological_sensi1.02597809
94MP0000569_abnormal_digit_pigmentation1.02331702
95MP0001819_abnormal_immune_cell1.02149702
96MP0004019_abnormal_vitamin_homeostasis1.01158439
97MP0002837_dystrophic_cardiac_calcinosis0.98353267
98MP0008469_abnormal_protein_level0.96582217
99MP0000604_amyloidosis0.96250240
100MP0003453_abnormal_keratinocyte_physiol0.95326675
101MP0003950_abnormal_plasma_membrane0.92231466
102MP0002069_abnormal_eating/drinking_beha0.92111781
103MP0004947_skin_inflammation0.91899263
104MP0004145_abnormal_muscle_electrophysio0.91543797
105MP0008260_abnormal_autophagy0.91299231
106MP0002229_neurodegeneration0.91037520
107MP0002405_respiratory_system_inflammati0.89565314
108MP0001188_hyperpigmentation0.88203805
109MP0004742_abnormal_vestibular_system0.85759929
110MP0006054_spinal_hemorrhage0.84274500
111MP0009333_abnormal_splenocyte_physiolog0.84086845
112MP0003122_maternal_imprinting0.83208710
113MP0004085_abnormal_heartbeat0.83188993
114MP0005535_abnormal_body_temperature0.82505844
115MP0003632_abnormal_nervous_system0.81355261
116MP0002090_abnormal_vision0.80801602
117MP0005394_taste/olfaction_phenotype0.80069282
118MP0005499_abnormal_olfactory_system0.80069282
119MP0001963_abnormal_hearing_physiology0.79652383
120MP0001664_abnormal_digestion0.77305407
121MP0000371_diluted_coat_color0.76537359
122MP0000685_abnormal_immune_system0.76433062
123MP0003075_altered_response_to0.76281285
124MP0003634_abnormal_glial_cell0.75842968
125MP0002332_abnormal_exercise_endurance0.75540098
126MP0004484_altered_response_of0.75341641
127MP0000920_abnormal_myelination0.74755422
128MP0005623_abnormal_meninges_morphology0.74058450
129MP0002254_reproductive_system_inflammat0.73366411
130MP0002752_abnormal_somatic_nervous0.73141087
131MP0005165_increased_susceptibility_to0.72625865
132MP0010234_abnormal_vibrissa_follicle0.71071861
133MP0005397_hematopoietic_system_phenotyp0.70149845
134MP0001545_abnormal_hematopoietic_system0.70149845
135MP0004510_myositis0.70036118
136MP0005464_abnormal_platelet_physiology0.70018183
137MP0004215_abnormal_myocardial_fiber0.70003043
138MP0002876_abnormal_thyroid_physiology0.69110188
139MP0000631_abnormal_neuroendocrine_gland0.68818388
140MP0005551_abnormal_eye_electrophysiolog0.67948321
141MP0001727_abnormal_embryo_implantation0.67711572
142MP0001177_atelectasis0.66665022
143MP0002653_abnormal_ependyma_morphology0.65274346
144MP0000013_abnormal_adipose_tissue0.64437685
145MP0005187_abnormal_penis_morphology0.62960351
146MP0000747_muscle_weakness0.62673782
147MP0004233_abnormal_muscle_weight0.61459351
148MP0003183_abnormal_peptide_metabolism0.61438619
149MP0000858_altered_metastatic_potential0.59469877
150MP0008961_abnormal_basal_metabolism0.58275051
151MP0001348_abnormal_lacrimal_gland0.57756852
152MP0003690_abnormal_glial_cell0.57400377
153MP0010386_abnormal_urinary_bladder0.57342498
154MP0003283_abnormal_digestive_organ0.56958804
155MP0003861_abnormal_nervous_system0.55408862
156MP0001943_abnormal_respiration0.54420732
157MP0010769_abnormal_survival0.53537702
158MP0001485_abnormal_pinna_reflex0.52933000
159MP0010770_preweaning_lethality0.51978913
160MP0002082_postnatal_lethality0.51978913
161MP0008004_abnormal_stomach_pH0.51517593
162MP0003956_abnormal_body_size0.51182116

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.66924872
2Increased cerebral lipofuscin (HP:0011813)7.37408715
3Myokymia (HP:0002411)7.10029373
4Increased neuronal autofluorescent lipopigment (HP:0002074)6.09821694
5Focal seizures (HP:0007359)6.07590156
6Visual hallucinations (HP:0002367)5.83536379
7Atonic seizures (HP:0010819)5.23908404
8Epileptic encephalopathy (HP:0200134)5.13101117
9Disinhibition (HP:0000734)5.08429247
10Vacuolated lymphocytes (HP:0001922)4.99246216
11Loss of speech (HP:0002371)4.89830929
12Febrile seizures (HP:0002373)4.64988973
13Dysostosis multiplex (HP:0000943)4.51707505
14Absence seizures (HP:0002121)4.39942411
15Systemic lupus erythematosus (HP:0002725)4.28125920
16Apathy (HP:0000741)4.23233363
17Generalized tonic-clonic seizures (HP:0002069)4.15245118
18Diminished motivation (HP:0000745)4.07575051
19Progressive cerebellar ataxia (HP:0002073)4.00642713
20Neuronal loss in central nervous system (HP:0002529)3.97299792
21Dialeptic seizures (HP:0011146)3.96364659
22Abnormality of macrophages (HP:0004311)3.94815889
23Abnormality of polysaccharide metabolism (HP:0011012)3.82954062
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.82954062
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.82954062
26Supranuclear gaze palsy (HP:0000605)3.75840460
27Impaired vibration sensation in the lower limbs (HP:0002166)3.66478640
28Broad-based gait (HP:0002136)3.58747095
29Ankle clonus (HP:0011448)3.57812448
30Poor eye contact (HP:0000817)3.57616714
31Action tremor (HP:0002345)3.54861175
32Urinary glycosaminoglycan excretion (HP:0003541)3.48902742
33Mucopolysacchariduria (HP:0008155)3.48902742
34Papilledema (HP:0001085)3.41353451
35Amblyopia (HP:0000646)3.39819064
36Axonal loss (HP:0003447)3.32432297
37Hyperventilation (HP:0002883)3.29693609
38Nuclear cataract (HP:0100018)3.25167871
39Termporal pattern (HP:0011008)3.24720547
40Insidious onset (HP:0003587)3.24720547
41Urinary bladder sphincter dysfunction (HP:0002839)3.23537849
42Autoimmune thrombocytopenia (HP:0001973)3.23474531
43Gaze-evoked nystagmus (HP:0000640)3.22223244
44Urinary urgency (HP:0000012)3.20121149
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.18830755
46Mutism (HP:0002300)3.16663287
47Impaired social interactions (HP:0000735)3.11574087
48Abnormal social behavior (HP:0012433)3.11574087
49Retinal atrophy (HP:0001105)3.10134080
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07543015
51Depression (HP:0000716)3.05904068
52Truncal ataxia (HP:0002078)2.95494597
53Glomerulonephritis (HP:0000099)2.94230354
54Abnormal eating behavior (HP:0100738)2.93761422
55Abnormality of the periventricular white matter (HP:0002518)2.91446321
56Postural instability (HP:0002172)2.91388635
57Dysmetria (HP:0001310)2.88606651
58Agnosia (HP:0010524)2.86860295
59Dementia (HP:0000726)2.83452873
60Myocardial infarction (HP:0001658)2.83043368
61Cerebral inclusion bodies (HP:0100314)2.81055988
62Anxiety (HP:0000739)2.77300129
63Dysdiadochokinesis (HP:0002075)2.76050872
64Recurrent gram-negative bacterial infections (HP:0005420)2.75256026
65Torticollis (HP:0000473)2.69613173
66Spastic gait (HP:0002064)2.66057417
67Abnormality of the corticospinal tract (HP:0002492)2.64384277
68Drooling (HP:0002307)2.63454411
69Excessive salivation (HP:0003781)2.63454411
70Global brain atrophy (HP:0002283)2.61378965
71Complement deficiency (HP:0004431)2.60652364
72Upper motor neuron abnormality (HP:0002127)2.60118469
73Epileptiform EEG discharges (HP:0011182)2.59341470
74Limb dystonia (HP:0002451)2.57924423
75Absent speech (HP:0001344)2.57824361
76Bradykinesia (HP:0002067)2.57388694
77Impaired smooth pursuit (HP:0007772)2.56736128
78Progressive neurologic deterioration (HP:0002344)2.55344135
79Abnormality of binocular vision (HP:0011514)2.53885308
80Diplopia (HP:0000651)2.53885308
81Focal dystonia (HP:0004373)2.53369242
82EEG with generalized epileptiform discharges (HP:0011198)2.51783282
83Impaired vibratory sensation (HP:0002495)2.51665103
84Scanning speech (HP:0002168)2.51642044
85Pheochromocytoma (HP:0002666)2.50856217
86Genetic anticipation (HP:0003743)2.47901622
87Progressive inability to walk (HP:0002505)2.47771615
88Stereotypic behavior (HP:0000733)2.45790731
89Recurrent bacterial skin infections (HP:0005406)2.44121596
90Inability to walk (HP:0002540)2.43916476
91Personality changes (HP:0000751)2.42547807
92Abnormality of the lower motor neuron (HP:0002366)2.42091619
93Fetal akinesia sequence (HP:0001989)2.42075972
94Polyphagia (HP:0002591)2.40959890
95Resting tremor (HP:0002322)2.39309010
96Neurofibrillary tangles (HP:0002185)2.39215297
97Hypsarrhythmia (HP:0002521)2.38659655
98Purpura (HP:0000979)2.36396036
99Eczematoid dermatitis (HP:0000976)2.30464553
100Megalencephaly (HP:0001355)2.27756811
101Craniofacial dystonia (HP:0012179)2.27107428
102Hemiparesis (HP:0001269)2.25691410
103Neuroendocrine neoplasm (HP:0100634)2.22998375
104Status epilepticus (HP:0002133)2.22773994
105Prolonged neonatal jaundice (HP:0006579)2.22391538
106Generalized myoclonic seizures (HP:0002123)2.20698103
107Lower limb muscle weakness (HP:0007340)2.20470354
108Delusions (HP:0000746)2.19626862
109Abnormality of the vasculature of the conjunctiva (HP:0008054)2.19208065
110Metaphyseal irregularity (HP:0003025)2.17708106
111Akinesia (HP:0002304)2.17360688
112Dysmetric saccades (HP:0000641)2.16964619
113Abnormality of ocular smooth pursuit (HP:0000617)2.14785960
114Increased serum ferritin (HP:0003281)2.13581212
115Recurrent abscess formation (HP:0002722)2.13497275
116Inappropriate behavior (HP:0000719)2.11659703
117Increased CSF protein (HP:0002922)2.08850751
118Intention tremor (HP:0002080)2.07671315
119Obstructive sleep apnea (HP:0002870)2.07386686
120Epidermoid cyst (HP:0200040)2.05312509
121Asymmetric septal hypertrophy (HP:0001670)2.01855221
122Amyotrophic lateral sclerosis (HP:0007354)2.01465175
123Peripheral demyelination (HP:0011096)2.01456823
124Abnormality of glycolipid metabolism (HP:0010969)10.8104469
125Abnormality of liposaccharide metabolism (HP:0010968)10.8104469
126Abnormality of glycosphingolipid metabolism (HP:0004343)10.8104469
127Blue irides (HP:0000635)1.99170506
128Incomplete penetrance (HP:0003829)1.98709724
129Agitation (HP:0000713)1.98170237
130Hepatosplenomegaly (HP:0001433)1.97787403
131Lower limb amyotrophy (HP:0007210)1.97501717
132Memory impairment (HP:0002354)1.97335695
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.96875841
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96875841
135Ventricular fibrillation (HP:0001663)1.96005578
136Hemiplegia (HP:0002301)1.95460549
137Skin nodule (HP:0200036)1.93937160
138Annular pancreas (HP:0001734)1.93355710
139Rapidly progressive (HP:0003678)1.93350497
140Poor head control (HP:0002421)1.91248141
141Hypoventilation (HP:0002791)1.90357997
142Pathologic fracture (HP:0002756)1.89512970
143Gait ataxia (HP:0002066)1.89045171
144Cardiomegaly (HP:0001640)1.88666900
145Hyperthyroidism (HP:0000836)1.88467692
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88345590
147Mediastinal lymphadenopathy (HP:0100721)1.87389429
148Ankyloglossia (HP:0010296)1.87152810
149Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85176333
150Hypoplasia of the brainstem (HP:0002365)1.85176333
151J-shaped sella turcica (HP:0002680)1.83607684
152Bundle branch block (HP:0011710)1.82762601
153Clonus (HP:0002169)1.82120512
154Intellectual disability, profound (HP:0002187)1.81130296
155Abnormality of salivation (HP:0100755)1.80994328
156Rigidity (HP:0002063)1.80935643
157Abnormality of complement system (HP:0005339)1.78170557
158Dysphonia (HP:0001618)1.77411554
159Xanthomatosis (HP:0000991)1.76503474
160Urinary incontinence (HP:0000020)1.75420134
161Peripheral hypomyelination (HP:0007182)1.73359645
162Spastic tetraparesis (HP:0001285)1.69682252
163Frequent falls (HP:0002359)1.68871610
164Multiple enchondromatosis (HP:0005701)1.67298113
165Abnormality of iron homeostasis (HP:0011031)1.67203632
166Interstitial pulmonary disease (HP:0006530)1.66001913
167Stomatitis (HP:0010280)1.62693742
168Myoclonus (HP:0001336)1.61963348
169Orchitis (HP:0100796)1.61815102
170Thoracic kyphosis (HP:0002942)1.56592830
171Spinal muscular atrophy (HP:0007269)1.54212386
172Amyloidosis (HP:0011034)1.54156510
173Basal ganglia calcification (HP:0002135)1.52392156
174Nausea (HP:0002018)1.50858030
175Segmental peripheral demyelination/remyelination (HP:0003481)1.50205016
176Abnormality of transition element cation homeostasis (HP:0011030)1.49800949
177Beaking of vertebral bodies (HP:0004568)1.47261215
178Optic neuritis (HP:0100653)1.46436083
179Retrobulbar optic neuritis (HP:0100654)1.46436083
180Conjunctival telangiectasia (HP:0000524)1.45337304
181Paralysis (HP:0003470)1.44564308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.30389631
2EPHA44.23623281
3MAP3K94.01133268
4NTRK33.83318336
5GRK73.58813938
6BLK3.45299011
7MARK13.30130581
8MAP3K43.10571712
9DAPK23.06191936
10MINK12.81768313
11MAP2K72.79333660
12RIPK42.73405398
13ACVR1B2.59971209
14MAP3K112.59284054
15MAP3K122.48752213
16PAK62.46016842
17CDK192.45772922
18DDR22.32370113
19KSR22.17254217
20NME22.16211170
21MAP2K42.11057649
22MAP3K142.00394590
23PLK21.94889797
24MATK1.93490431
25DAPK11.89709929
26PDK21.88601587
27TAOK21.87375818
28ABL21.87312544
29CASK1.79168673
30CAMKK11.72676320
31PRKD31.63887428
32NTRK21.62447885
33GRK51.61293721
34NTRK11.56876689
35KSR11.55089719
36LATS21.53098665
37MAPK131.52276107
38TBK11.49719573
39CDK51.49259391
40TGFBR21.47213760
41PNCK1.44531734
42PIM21.39171580
43MOS1.34901904
44MAP3K21.32540423
45MAP2K61.25840060
46CSK1.23717540
47ARAF1.22485606
48OXSR11.20892541
49PRKCG1.16834417
50MAP3K131.15685444
51CAMKK21.15191266
52BMPR21.11370433
53SIK21.10034468
54UHMK11.08713776
55CDC42BPA1.08519136
56PRPF4B1.08354665
57PHKG21.08007109
58PHKG11.08007109
59RIPK11.06432816
60MAP3K31.06030199
61ERN11.06014065
62TNIK1.05406485
63IKBKB1.04736069
64MAP3K50.96418749
65CDK180.94803307
66PTK2B0.94154334
67RET0.94101050
68FES0.93946870
69MAP2K30.93118759
70TAOK10.93066987
71CDK150.92764542
72CDK140.92296843
73TYRO30.89832647
74CAMK2A0.89184154
75STK380.88989079
76CAMK1D0.88307309
77STK110.87320021
78ZAP700.86985513
79CAMK10.83315248
80CCNB10.81616317
81TYK20.81567521
82CDK11A0.81401760
83RAF10.79974402
84CSNK1G20.78870489
85IRAK20.76314842
86SYK0.76013516
87TXK0.75245842
88TESK10.72389776
89FGR0.72235333
90PDK10.71195049
91PAK30.70849758
92JAK20.70145806
93LMTK20.69975954
94SCYL20.68337706
95LYN0.68277956
96PDPK10.66799148
97PRKCH0.65322358
98DYRK1A0.65004501
99JAK10.63986361
100SGK4940.63865391
101SGK2230.63865391
102RPS6KA20.62700255
103MAP3K60.62598804
104DAPK30.62420191
105MARK30.57238007
106MARK20.57144373
107TESK20.56282370
108NME10.56046969
109ALK0.55819194
110PKN10.55124020
111SGK10.54162265
112MAP3K10.53890477
113MAP2K10.51469556
114MAPK40.49514312
115CAMK2B0.49002910
116TAOK30.48838630
117PRKCE0.48358791
118CAMK1G0.46496635
119EPHA30.46457704
120PRKCZ0.44291255
121MAP4K10.42256718
122PIM10.41563259
123PINK10.41562756
124MAPK120.40345131
125NEK60.40291754
126CHUK0.38531291
127PDK30.38479938
128PDK40.38479938
129ADRBK10.38210135
130FYN0.37164563
131RPS6KA30.36181497
132GRK60.35790252
133SGK20.35757854
134FER0.34976204
135CAMK2G0.34765982
136LCK0.34654215
137LIMK10.33864543
138ADRBK20.33829161
139NEK10.33358384
140CAMK40.33299724
141ROCK20.29707222
142BRSK10.29607463
143MAP3K70.28553481
144SGK30.28072764
145MAPK100.27958931
146FGFR20.27550611
147BCR0.26384350

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041424.59837486
2Other glycan degradation_Homo sapiens_hsa005113.94531524
3Synaptic vesicle cycle_Homo sapiens_hsa047213.82105515
4Nicotine addiction_Homo sapiens_hsa050333.32172292
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.28365321
6Olfactory transduction_Homo sapiens_hsa047402.86662149
7Staphylococcus aureus infection_Homo sapiens_hsa051502.81387619
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59356872
9Circadian entrainment_Homo sapiens_hsa047132.59316187
10Long-term potentiation_Homo sapiens_hsa047202.57888028
11Glutamatergic synapse_Homo sapiens_hsa047242.48254966
12GABAergic synapse_Homo sapiens_hsa047272.47602131
13Morphine addiction_Homo sapiens_hsa050322.47567665
14Amphetamine addiction_Homo sapiens_hsa050312.43510767
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32312549
16Osteoclast differentiation_Homo sapiens_hsa043802.21982501
17Salivary secretion_Homo sapiens_hsa049702.17251178
18Phagosome_Homo sapiens_hsa041452.16928414
19Dopaminergic synapse_Homo sapiens_hsa047282.16862772
20Asthma_Homo sapiens_hsa053102.11535980
21Tuberculosis_Homo sapiens_hsa051522.11076515
22Collecting duct acid secretion_Homo sapiens_hsa049662.00217963
23Insulin secretion_Homo sapiens_hsa049111.98044586
24Gastric acid secretion_Homo sapiens_hsa049711.92672166
25Leishmaniasis_Homo sapiens_hsa051401.89724551
26Cholinergic synapse_Homo sapiens_hsa047251.88224333
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80139687
28Taste transduction_Homo sapiens_hsa047421.77144361
29Renin secretion_Homo sapiens_hsa049241.75220958
30Oxytocin signaling pathway_Homo sapiens_hsa049211.66627533
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64970640
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64408209
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64212819
34Long-term depression_Homo sapiens_hsa047301.63933251
35Allograft rejection_Homo sapiens_hsa053301.63930197
36Serotonergic synapse_Homo sapiens_hsa047261.63532918
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63462906
38Pertussis_Homo sapiens_hsa051331.59117107
39Calcium signaling pathway_Homo sapiens_hsa040201.48489955
40GnRH signaling pathway_Homo sapiens_hsa049121.43474786
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.43402826
42Cocaine addiction_Homo sapiens_hsa050301.41972616
43Salmonella infection_Homo sapiens_hsa051321.40137958
44Graft-versus-host disease_Homo sapiens_hsa053321.39294005
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.39077846
46Gap junction_Homo sapiens_hsa045401.36300916
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35167529
48Malaria_Homo sapiens_hsa051441.33328516
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27697875
50Autoimmune thyroid disease_Homo sapiens_hsa053201.26997420
51Vibrio cholerae infection_Homo sapiens_hsa051101.26943830
52Sphingolipid metabolism_Homo sapiens_hsa006001.25911347
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25506410
54Glioma_Homo sapiens_hsa052141.24946880
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.20837388
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20187663
57Axon guidance_Homo sapiens_hsa043601.18595065
58TNF signaling pathway_Homo sapiens_hsa046681.18165902
59cAMP signaling pathway_Homo sapiens_hsa040241.17395646
60Estrogen signaling pathway_Homo sapiens_hsa049151.16157567
61Legionellosis_Homo sapiens_hsa051341.13623773
62ErbB signaling pathway_Homo sapiens_hsa040121.12589968
63Cardiac muscle contraction_Homo sapiens_hsa042601.11768300
64Antigen processing and presentation_Homo sapiens_hsa046121.11346218
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10845809
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08766238
67Toxoplasmosis_Homo sapiens_hsa051451.07755338
68Type II diabetes mellitus_Homo sapiens_hsa049301.07343460
69Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07066621
70NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06229249
71Melanogenesis_Homo sapiens_hsa049161.04330373
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00241603
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98074998
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93015394
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92388631
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.91672844
77* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90698096
78Dorso-ventral axis formation_Homo sapiens_hsa043200.89607571
79Oocyte meiosis_Homo sapiens_hsa041140.88995124
80Mineral absorption_Homo sapiens_hsa049780.87820766
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86465298
82Complement and coagulation cascades_Homo sapiens_hsa046100.86158703
83PPAR signaling pathway_Homo sapiens_hsa033200.84066411
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80657060
85Hematopoietic cell lineage_Homo sapiens_hsa046400.78524321
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.76947287
87Oxidative phosphorylation_Homo sapiens_hsa001900.76785832
88Alzheimers disease_Homo sapiens_hsa050100.75849398
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74193199
90VEGF signaling pathway_Homo sapiens_hsa043700.73629311
91Pancreatic secretion_Homo sapiens_hsa049720.70513200
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.69485453
93Phototransduction_Homo sapiens_hsa047440.69221483
94Thyroid hormone synthesis_Homo sapiens_hsa049180.67730323
95Choline metabolism in cancer_Homo sapiens_hsa052310.67586711
96MAPK signaling pathway_Homo sapiens_hsa040100.66481730
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64008328
98B cell receptor signaling pathway_Homo sapiens_hsa046620.63261424
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.62981841
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62669708
101Viral myocarditis_Homo sapiens_hsa054160.62489117
102Glucagon signaling pathway_Homo sapiens_hsa049220.61004810
103Ras signaling pathway_Homo sapiens_hsa040140.60753887
104Nitrogen metabolism_Homo sapiens_hsa009100.59127472
105Dilated cardiomyopathy_Homo sapiens_hsa054140.58399083
106Apoptosis_Homo sapiens_hsa042100.58029455
107Parkinsons disease_Homo sapiens_hsa050120.56583146
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56253267
109Shigellosis_Homo sapiens_hsa051310.55497704
110Influenza A_Homo sapiens_hsa051640.55435768
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55049402
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55036090
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53664163
114mTOR signaling pathway_Homo sapiens_hsa041500.53500756
115Rap1 signaling pathway_Homo sapiens_hsa040150.52735551
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.49341805
117Endocytosis_Homo sapiens_hsa041440.49251814
118Renal cell carcinoma_Homo sapiens_hsa052110.48426258
119Insulin signaling pathway_Homo sapiens_hsa049100.45824568
120Prion diseases_Homo sapiens_hsa050200.45436701
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44070715
122Non-small cell lung cancer_Homo sapiens_hsa052230.43959375
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43629769
124Fructose and mannose metabolism_Homo sapiens_hsa000510.43098768
125Systemic lupus erythematosus_Homo sapiens_hsa053220.43054309
126African trypanosomiasis_Homo sapiens_hsa051430.42840856
127Endometrial cancer_Homo sapiens_hsa052130.42840089
128Ether lipid metabolism_Homo sapiens_hsa005650.42745664
129Inositol phosphate metabolism_Homo sapiens_hsa005620.42165610
130Alcoholism_Homo sapiens_hsa050340.42074609
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41229438
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41046223
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40126122
134Wnt signaling pathway_Homo sapiens_hsa043100.40044659
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39958244
136Galactose metabolism_Homo sapiens_hsa000520.38608373
137Hepatitis C_Homo sapiens_hsa051600.37984691
138Amoebiasis_Homo sapiens_hsa051460.37952726
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37814953
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36735275
141Bile secretion_Homo sapiens_hsa049760.36504032
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35845585
143Chemokine signaling pathway_Homo sapiens_hsa040620.35308777
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34470721
145Rheumatoid arthritis_Homo sapiens_hsa053230.33496964
146Type I diabetes mellitus_Homo sapiens_hsa049400.31306409
147Vitamin B6 metabolism_Homo sapiens_hsa007500.31194445
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31061836
149Colorectal cancer_Homo sapiens_hsa052100.30812356
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29750438
151AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28843509
152Fatty acid biosynthesis_Homo sapiens_hsa000610.21812089

Most similar genes based on co-expression Upload to Enrichr

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