HS3ST5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.73473144
2synaptic vesicle exocytosis (GO:0016079)5.61802518
3presynaptic membrane organization (GO:0097090)5.47842006
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37781697
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.34546004
6protein localization to synapse (GO:0035418)5.14867108
7protein-cofactor linkage (GO:0018065)4.94843968
8layer formation in cerebral cortex (GO:0021819)4.90577385
9regulation of synaptic vesicle exocytosis (GO:2000300)4.89114200
10neuron cell-cell adhesion (GO:0007158)4.80186154
11glutamate secretion (GO:0014047)4.75882954
12synaptic vesicle maturation (GO:0016188)4.74405732
13neurotransmitter-gated ion channel clustering (GO:0072578)4.58969778
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52824134
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.52528372
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.50016084
17positive regulation of synapse maturation (GO:0090129)4.40108004
18vocalization behavior (GO:0071625)4.36162701
19regulation of synaptic vesicle transport (GO:1902803)4.21385210
20regulation of glutamate receptor signaling pathway (GO:1900449)4.13642175
21pyrimidine nucleobase catabolic process (GO:0006208)4.09367017
22neuronal action potential propagation (GO:0019227)4.08311434
23neurotransmitter secretion (GO:0007269)4.02966760
24neuron recognition (GO:0008038)3.88038369
25positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.81969453
26cellular potassium ion homeostasis (GO:0030007)3.66034077
27proline transport (GO:0015824)3.56780656
28cerebellar Purkinje cell differentiation (GO:0021702)3.55567748
29behavioral response to ethanol (GO:0048149)3.55541372
30regulation of synapse structural plasticity (GO:0051823)3.55019912
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52032407
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.51760316
33synaptic vesicle endocytosis (GO:0048488)3.50452334
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50131309
35cell migration in hindbrain (GO:0021535)3.50079283
36regulation of synapse maturation (GO:0090128)3.49998857
37neuron-neuron synaptic transmission (GO:0007270)3.48628639
38axonal fasciculation (GO:0007413)3.48413691
39positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46038233
40exploration behavior (GO:0035640)3.43832837
41locomotory exploration behavior (GO:0035641)3.42491430
42glutamate receptor signaling pathway (GO:0007215)3.41757108
43neurotransmitter transport (GO:0006836)3.39674135
44mating behavior (GO:0007617)3.39654823
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.37289201
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.37231802
47negative regulation of microtubule polymerization (GO:0031115)3.34239100
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.32992195
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32051680
50positive regulation of mitochondrial fission (GO:0090141)3.28194806
51prepulse inhibition (GO:0060134)3.27837697
52regulation of vesicle fusion (GO:0031338)3.25324665
53adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.23670554
54regulation of neurotransmitter secretion (GO:0046928)3.22763757
55regulation of neuronal synaptic plasticity (GO:0048168)3.21379694
56gamma-aminobutyric acid transport (GO:0015812)3.18223380
57synapse assembly (GO:0007416)3.17553159
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17016670
59positive regulation of membrane potential (GO:0045838)3.13753258
60nonmotile primary cilium assembly (GO:0035058)3.13482956
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12950159
62negative regulation of dendrite morphogenesis (GO:0050774)3.12910674
63activation of protein kinase A activity (GO:0034199)3.12545886
64regulation of neurotransmitter levels (GO:0001505)3.11722391
65regulation of neurotransmitter transport (GO:0051588)3.11644296
66neuromuscular process controlling posture (GO:0050884)3.10298942
67response to histamine (GO:0034776)3.08957412
68nucleobase catabolic process (GO:0046113)3.08941262
69protein neddylation (GO:0045116)3.08391559
70synaptic transmission, glutamatergic (GO:0035249)3.08302650
71mitochondrion transport along microtubule (GO:0047497)3.08129531
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.08129531
73detection of calcium ion (GO:0005513)3.07051355
74regulation of long-term neuronal synaptic plasticity (GO:0048169)3.06778427
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06679783
76righting reflex (GO:0060013)3.06302932
77long-term memory (GO:0007616)3.06200205
78regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.06059862
79regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.06059862
80organelle transport along microtubule (GO:0072384)3.05220803
81vesicle transport along microtubule (GO:0047496)3.05056990
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04450711
83innervation (GO:0060384)3.03867700
84ionotropic glutamate receptor signaling pathway (GO:0035235)3.02100850
85establishment of synaptic vesicle localization (GO:0097480)3.02047342
86synaptic vesicle transport (GO:0048489)3.02047342
87establishment of mitochondrion localization (GO:0051654)3.01402831
88neurofilament cytoskeleton organization (GO:0060052)3.01354780
89axon cargo transport (GO:0008088)3.01330690
90negative regulation of dendrite development (GO:2000171)3.01295291
91regulation of postsynaptic membrane potential (GO:0060078)3.01091969
92response to pheromone (GO:0019236)2.98229612
93regulation of dendritic spine morphogenesis (GO:0061001)2.98223030
94behavioral response to cocaine (GO:0048148)2.97117810
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.96321886
96membrane depolarization during action potential (GO:0086010)2.94376385
97synaptic transmission, dopaminergic (GO:0001963)2.94018252
98DNA damage response, detection of DNA damage (GO:0042769)2.92820072
99striatum development (GO:0021756)2.92462395
100regulation of cAMP-dependent protein kinase activity (GO:2000479)2.91552223
101dendritic spine morphogenesis (GO:0060997)2.90718261
102dopamine receptor signaling pathway (GO:0007212)2.90714872
103establishment of vesicle localization (GO:0051650)2.89302024
104synaptic transmission (GO:0007268)2.89042061
105neuromuscular synaptic transmission (GO:0007274)2.87795451
106transmission of nerve impulse (GO:0019226)2.87120357
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86139794
108response to auditory stimulus (GO:0010996)2.86043179
109cerebellar granule cell differentiation (GO:0021707)2.85413721
110postsynaptic membrane organization (GO:0001941)2.84022063
111membrane assembly (GO:0071709)2.73028542
112DNA double-strand break processing (GO:0000729)2.71671560
113L-serine metabolic process (GO:0006563)2.69651431
114eosinophil chemotaxis (GO:0048245)2.66898321
115establishment of protein localization to mitochondrial membrane (GO:0090151)2.66032755
116IMP biosynthetic process (GO:0006188)2.60786042
117otic vesicle formation (GO:0030916)2.58952498
118negative regulation of DNA recombination (GO:0045910)2.58695456
119positive regulation of synapse assembly (GO:0051965)2.57570284
120negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54996077
121negative regulation of translation, ncRNA-mediated (GO:0040033)2.54996077
122regulation of translation, ncRNA-mediated (GO:0045974)2.54996077
123establishment of integrated proviral latency (GO:0075713)2.53924947
124regulation of gene silencing by RNA (GO:0060966)2.52477622
125regulation of posttranscriptional gene silencing (GO:0060147)2.52477622
126regulation of gene silencing by miRNA (GO:0060964)2.52477622
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.48946696
128termination of RNA polymerase III transcription (GO:0006386)2.48537462
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.48537462
130behavioral response to nicotine (GO:0035095)2.46644390
131dicarboxylic acid catabolic process (GO:0043649)2.45482510
132neuronal action potential (GO:0019228)2.44763911
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41776973
134ATP synthesis coupled proton transport (GO:0015986)2.41776973
135calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.41261059
136chaperone-mediated protein transport (GO:0072321)2.38655021
137neurotransmitter uptake (GO:0001504)2.38506241
138eosinophil migration (GO:0072677)2.37781077
139regulation of synapse assembly (GO:0051963)2.37397493
140retinal cone cell development (GO:0046549)2.35702959
141negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35425399
142paraxial mesoderm development (GO:0048339)2.35374466
143neurotransmitter biosynthetic process (GO:0042136)2.34765260
144telomere maintenance via telomerase (GO:0007004)2.32360378
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31808754
146IMP metabolic process (GO:0046040)2.30464346
147negative regulation of sister chromatid segregation (GO:0033046)2.28321192
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.28321192
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.28321192
150negative regulation of mitotic sister chromatid segregation (GO:0033048)2.28321192
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.28321192
152long-chain fatty acid biosynthetic process (GO:0042759)2.27676784
153kidney morphogenesis (GO:0060993)2.27512971
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.26684973
155synapse organization (GO:0050808)2.26379288
156regulation of meiosis I (GO:0060631)2.26226918
157C4-dicarboxylate transport (GO:0015740)2.26220223
158negative regulation of cytosolic calcium ion concentration (GO:0051481)2.25228117
159negative regulation of membrane potential (GO:0045837)2.22505714
160limb bud formation (GO:0060174)2.21972817
161anterior/posterior axis specification, embryo (GO:0008595)2.21622534
162regulation of mitotic spindle checkpoint (GO:1903504)2.21364637
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.21364637
164regulation of helicase activity (GO:0051095)2.20314644
165regulation of cilium movement (GO:0003352)2.17209389
166negative regulation of chromosome segregation (GO:0051985)2.16206553
167succinate metabolic process (GO:0006105)2.16043190
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.16013398
169regulation of sarcomere organization (GO:0060297)2.14880615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60357367
2GBX2_23144817_ChIP-Seq_PC3_Human3.77693133
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98650792
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95752679
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.93753206
6TAF15_26573619_Chip-Seq_HEK293_Human2.90739164
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81981829
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75067536
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58778187
10REST_21632747_ChIP-Seq_MESCs_Mouse2.55946438
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54041575
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54041575
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.53466450
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49657357
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43441268
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41189924
17AR_21572438_ChIP-Seq_LNCaP_Human2.37444079
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34536828
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34249295
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34139264
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32365994
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26917545
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.20741954
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.16791317
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12840308
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.09446150
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08657491
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.06882689
29BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03247436
30POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01394192
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00431329
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99470010
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98893087
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.95846056
35DROSHA_22980978_ChIP-Seq_HELA_Human1.90433617
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90343612
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87997854
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.87516621
39SMAD4_21799915_ChIP-Seq_A2780_Human1.79252357
40* EWS_26573619_Chip-Seq_HEK293_Human1.77644325
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76507904
42* P300_19829295_ChIP-Seq_ESCs_Human1.75807841
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73704709
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.69943557
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68561052
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67394997
47* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62893909
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61590367
49ZNF274_21170338_ChIP-Seq_K562_Hela1.60859959
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57178692
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.56593332
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54255535
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54161346
54* RNF2_27304074_Chip-Seq_NSC_Mouse1.52465785
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.52436195
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50868857
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48954315
58* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47335383
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.46901007
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45746151
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.45204824
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.44582613
63IGF1R_20145208_ChIP-Seq_DFB_Human1.43792326
64AR_25329375_ChIP-Seq_VCAP_Human1.43144211
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41938192
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.41886353
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41602348
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.41294990
69* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41195394
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.39705088
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37209077
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36312074
73* STAT3_23295773_ChIP-Seq_U87_Human1.35555899
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33532484
75FUS_26573619_Chip-Seq_HEK293_Human1.32474766
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.31672646
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30871854
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26114036
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24974029
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24970933
81VDR_22108803_ChIP-Seq_LS180_Human1.24830390
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24676546
83BCAT_22108803_ChIP-Seq_LS180_Human1.22896770
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21836683
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21474353
86* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20919962
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20436411
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19095154
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17840629
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15958682
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14337016
92TCF4_23295773_ChIP-Seq_U87_Human1.12917493
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12406661
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11925964
95SOX9_26525672_Chip-Seq_HEART_Mouse1.11568991
96JUN_21703547_ChIP-Seq_K562_Human1.10602998
97AR_19668381_ChIP-Seq_PC3_Human1.10403963
98* EZH2_27294783_Chip-Seq_NPCs_Mouse1.10387566
99* RUNX2_22187159_ChIP-Seq_PCA_Human1.10271614
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09864551
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09709371
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09203472
103* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07300178
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06269692
105ER_23166858_ChIP-Seq_MCF-7_Human1.05889696
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05297653
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.05047786
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.04441493
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03515003
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03456440
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03314755
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02544117
113AHR_22903824_ChIP-Seq_MCF-7_Human1.02329419
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.01095939
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00875230
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00875230
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00875230
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00308645
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00032895
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00032895
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99366131
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99031494
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99026687
124HTT_18923047_ChIP-ChIP_STHdh_Human0.98765434
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98126048
126POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97834499
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.97456208
128ELK1_19687146_ChIP-ChIP_HELA_Human0.96741136
129SOX2_19829295_ChIP-Seq_ESCs_Human0.96451090
130NANOG_19829295_ChIP-Seq_ESCs_Human0.96451090
131* KDM2B_26808549_Chip-Seq_REH_Human0.95917993
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.95487170
133MYC_18940864_ChIP-ChIP_HL60_Human0.95464729
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95130836
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94644459
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94060827
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93971064
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93865284
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.93773156
140* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92900751
141* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92799030
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91573847
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91402285
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90772133
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90600210
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90344166
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89716608
148* FLI1_21867929_ChIP-Seq_TH2_Mouse0.88354194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.40789253
2MP0003880_abnormal_central_pattern4.18528017
3MP0004270_analgesia3.69781088
4MP0003635_abnormal_synaptic_transmissio3.45655282
5MP0006276_abnormal_autonomic_nervous3.11745046
6MP0009046_muscle_twitch3.07627455
7MP0001968_abnormal_touch/_nociception3.04692232
8MP0002734_abnormal_mechanical_nocicepti3.01649439
9MP0009745_abnormal_behavioral_response2.80852191
10MP0001984_abnormal_olfaction2.80562551
11MP0002822_catalepsy2.78558868
12MP0002735_abnormal_chemical_nociception2.70860076
13MP0002063_abnormal_learning/memory/cond2.68365076
14MP0003941_abnormal_skin_development2.63031116
15MP0002064_seizures2.58612120
16MP0002272_abnormal_nervous_system2.43949331
17MP0002736_abnormal_nociception_after2.43786028
18MP0002572_abnormal_emotion/affect_behav2.42945757
19MP0002733_abnormal_thermal_nociception2.39816505
20MP0002184_abnormal_innervation2.34544786
21MP0010386_abnormal_urinary_bladder2.26880439
22MP0001970_abnormal_pain_threshold2.20941041
23MP0008877_abnormal_DNA_methylation2.19474054
24MP0002067_abnormal_sensory_capabilities2.17454063
25MP0005423_abnormal_somatic_nervous2.12391444
26MP0001486_abnormal_startle_reflex2.11974687
27MP0001440_abnormal_grooming_behavior2.10551817
28MP0001501_abnormal_sleep_pattern2.08926357
29MP0001529_abnormal_vocalization2.08717479
30MP0006292_abnormal_olfactory_placode2.01685273
31MP0003890_abnormal_embryonic-extraembry2.00605642
32MP0000778_abnormal_nervous_system1.91602172
33MP0004858_abnormal_nervous_system1.91283890
34MP0005386_behavior/neurological_phenoty1.81376353
35MP0004924_abnormal_behavior1.81376353
36MP0005551_abnormal_eye_electrophysiolog1.75021267
37MP0003567_abnormal_fetal_cardiomyocyte1.73256669
38MP0000569_abnormal_digit_pigmentation1.69518675
39MP0002909_abnormal_adrenal_gland1.61395796
40MP0008569_lethality_at_weaning1.59087478
41MP0000751_myopathy1.59048869
42MP0002557_abnormal_social/conspecific_i1.58208121
43MP0008058_abnormal_DNA_repair1.58041822
44MP0000955_abnormal_spinal_cord1.56921054
45MP0004811_abnormal_neuron_physiology1.56247271
46MP0003329_amyloid_beta_deposits1.55798333
47MP0005645_abnormal_hypothalamus_physiol1.51778088
48MP0001905_abnormal_dopamine_level1.50405304
49MP0005646_abnormal_pituitary_gland1.50217481
50MP0002882_abnormal_neuron_morphology1.49269056
51MP0002837_dystrophic_cardiac_calcinosis1.46534203
52MP0005499_abnormal_olfactory_system1.43497004
53MP0005394_taste/olfaction_phenotype1.43497004
54MP0003646_muscle_fatigue1.43404957
55MP0001502_abnormal_circadian_rhythm1.42479262
56MP0003122_maternal_imprinting1.41683791
57MP0003787_abnormal_imprinting1.40751703
58MP0003879_abnormal_hair_cell1.36592105
59MP0003123_paternal_imprinting1.35708190
60MP0001188_hyperpigmentation1.34424595
61MP0006072_abnormal_retinal_apoptosis1.31473475
62MP0002066_abnormal_motor_capabilities/c1.29837594
63MP0004145_abnormal_muscle_electrophysio1.26368989
64MP0000749_muscle_degeneration1.24937378
65MP0001293_anophthalmia1.22734779
66MP0008789_abnormal_olfactory_epithelium1.21692333
67MP0003136_yellow_coat_color1.21359771
68MP0002229_neurodegeneration1.19959870
69MP0002233_abnormal_nose_morphology1.17787553
70MP0004142_abnormal_muscle_tone1.16215222
71MP0004233_abnormal_muscle_weight1.16171784
72MP0004215_abnormal_myocardial_fiber1.15550387
73MP0002752_abnormal_somatic_nervous1.15091793
74MP0003937_abnormal_limbs/digits/tail_de1.14743689
75MP0009672_abnormal_birth_weight1.12832418
76MP0002638_abnormal_pupillary_reflex1.10328858
77MP0003385_abnormal_body_wall1.08570766
78MP0002160_abnormal_reproductive_system1.05425511
79MP0008872_abnormal_physiological_respon1.04653556
80MP0004742_abnormal_vestibular_system1.04375540
81MP0003119_abnormal_digestive_system1.04209694
82MP0002090_abnormal_vision1.04189201
83MP0000631_abnormal_neuroendocrine_gland0.99961424
84MP0002152_abnormal_brain_morphology0.99431363
85MP0002751_abnormal_autonomic_nervous0.95232061
86MP0003633_abnormal_nervous_system0.93258419
87MP0004036_abnormal_muscle_relaxation0.92156405
88MP0000049_abnormal_middle_ear0.91334580
89MP0004133_heterotaxia0.90804809
90MP0004085_abnormal_heartbeat0.90755924
91MP0003315_abnormal_perineum_morphology0.90743408
92MP0001286_abnormal_eye_development0.85589921
93MP0002102_abnormal_ear_morphology0.84151991
94MP0001963_abnormal_hearing_physiology0.84128759
95MP0003718_maternal_effect0.83687649
96MP0003632_abnormal_nervous_system0.83543153
97MP0008874_decreased_physiological_sensi0.81437247
98MP0003011_delayed_dark_adaptation0.81371397
99MP0002069_abnormal_eating/drinking_beha0.80828104
100MP0002106_abnormal_muscle_physiology0.80748169
101MP0009703_decreased_birth_body0.80619978
102MP0003631_nervous_system_phenotype0.80118776
103MP0003938_abnormal_ear_development0.79263495
104MP0002697_abnormal_eye_size0.78025264
105MP0000516_abnormal_urinary_system0.75480878
106MP0005367_renal/urinary_system_phenotyp0.75480878
107MP0003755_abnormal_palate_morphology0.75255323
108MP0005253_abnormal_eye_physiology0.73441930
109MP0002081_perinatal_lethality0.72653492
110MP0000647_abnormal_sebaceous_gland0.71872693
111MP0009780_abnormal_chondrocyte_physiolo0.71030087
112MP0001986_abnormal_taste_sensitivity0.69860452
113MP0005620_abnormal_muscle_contractility0.69717792
114MP0005535_abnormal_body_temperature0.69492242
115MP0004885_abnormal_endolymph0.68596226
116MP0003121_genomic_imprinting0.68264319
117MP0005195_abnormal_posterior_eye0.68188158
118MP0000538_abnormal_urinary_bladder0.67683854
119MP0000747_muscle_weakness0.67168338
120MP0003634_abnormal_glial_cell0.67068908
121MP0003137_abnormal_impulse_conducting0.66288469
122MP0010234_abnormal_vibrissa_follicle0.65652843
123MP0000013_abnormal_adipose_tissue0.63815766
124MP0001348_abnormal_lacrimal_gland0.63585133
125MP0005187_abnormal_penis_morphology0.62811839
126MP0004484_altered_response_of0.62325879
127MP0003861_abnormal_nervous_system0.62252323
128MP0001943_abnormal_respiration0.61169973
129MP0001485_abnormal_pinna_reflex0.60213775
130MP0002876_abnormal_thyroid_physiology0.58909799
131MP0001177_atelectasis0.58095600
132MP0001299_abnormal_eye_distance/0.55140360
133MP0000604_amyloidosis0.54547599

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.24393515
2Myokymia (HP:0002411)6.01313960
3Atonic seizures (HP:0010819)5.13364554
4Focal seizures (HP:0007359)4.80264235
5Absence seizures (HP:0002121)4.79991370
6Febrile seizures (HP:0002373)4.53317600
7Epileptic encephalopathy (HP:0200134)4.46231396
8Visual hallucinations (HP:0002367)4.38023930
9Dialeptic seizures (HP:0011146)4.08977149
10Generalized tonic-clonic seizures (HP:0002069)3.98735388
11Progressive cerebellar ataxia (HP:0002073)3.93443596
12Spastic diplegia (HP:0001264)3.92213619
13Abnormality of the labia minora (HP:0012880)3.59622589
14Termporal pattern (HP:0011008)3.37733501
15Insidious onset (HP:0003587)3.37733501
16Action tremor (HP:0002345)3.27886815
17Colon cancer (HP:0003003)3.23191166
18Pheochromocytoma (HP:0002666)3.22518997
19Limb dystonia (HP:0002451)3.22305894
20Ankle clonus (HP:0011448)3.20829325
21Hyperventilation (HP:0002883)3.11305872
22Exercise-induced muscle cramps (HP:0003710)2.97549682
23Hepatoblastoma (HP:0002884)2.96419294
24Broad-based gait (HP:0002136)2.91917595
25EEG with generalized epileptiform discharges (HP:0011198)2.89506229
26Dysdiadochokinesis (HP:0002075)2.88928041
27Vaginal atresia (HP:0000148)2.88890805
28Anxiety (HP:0000739)2.86548283
29Epileptiform EEG discharges (HP:0011182)2.86347630
30Neuroendocrine neoplasm (HP:0100634)2.82689452
31Abnormality of the corticospinal tract (HP:0002492)2.82474326
32Truncal ataxia (HP:0002078)2.81817715
33Gaze-evoked nystagmus (HP:0000640)2.81778271
34Fetal akinesia sequence (HP:0001989)2.80550419
35Supranuclear gaze palsy (HP:0000605)2.80362832
36Nephrogenic diabetes insipidus (HP:0009806)2.70730797
37Urinary bladder sphincter dysfunction (HP:0002839)2.69064469
38Urinary urgency (HP:0000012)2.68255591
39Hypothermia (HP:0002045)2.65557685
40Hyperglycinemia (HP:0002154)2.62659633
41Increased hepatocellular lipid droplets (HP:0006565)2.61642265
42Depression (HP:0000716)2.61589168
43Mutism (HP:0002300)2.59797168
44Drooling (HP:0002307)2.57745862
45Excessive salivation (HP:0003781)2.57745862
46Abnormality of macular pigmentation (HP:0008002)2.52608591
47Poor eye contact (HP:0000817)2.52063661
48Septo-optic dysplasia (HP:0100842)2.51916606
49Ulnar claw (HP:0001178)2.51575103
50Amblyopia (HP:0000646)2.51212951
51Progressive inability to walk (HP:0002505)2.50736726
52Polyphagia (HP:0002591)2.46857095
53Hypsarrhythmia (HP:0002521)2.44799735
54Inability to walk (HP:0002540)2.44662193
55Split foot (HP:0001839)2.43377633
56Gait imbalance (HP:0002141)2.42105321
57Impaired vibration sensation in the lower limbs (HP:0002166)2.41791198
58Agitation (HP:0000713)2.41585816
59Volvulus (HP:0002580)2.35866475
60Abnormal eating behavior (HP:0100738)2.33849479
61Poor coordination (HP:0002370)2.31688989
62Dysmetria (HP:0001310)2.31051791
63Impaired social interactions (HP:0000735)2.28946416
64Abnormal social behavior (HP:0012433)2.28946416
65Spastic gait (HP:0002064)2.26110610
66Congenital stationary night blindness (HP:0007642)2.23920892
67Failure to thrive in infancy (HP:0001531)2.23787689
68Central scotoma (HP:0000603)2.23700768
69Scanning speech (HP:0002168)2.23031714
70Partial agenesis of the corpus callosum (HP:0001338)2.21223805
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.20060404
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20060404
73Nemaline bodies (HP:0003798)2.19038557
74Abnormal EKG (HP:0003115)2.18795412
75Torticollis (HP:0000473)2.18724244
76Type 2 muscle fiber atrophy (HP:0003554)2.17372437
77Absent speech (HP:0001344)2.17365525
78Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16496654
79Hypoplasia of the brainstem (HP:0002365)2.16496654
80Genetic anticipation (HP:0003743)2.16363423
81Lipid accumulation in hepatocytes (HP:0006561)2.15774365
82Renal Fanconi syndrome (HP:0001994)2.15471055
83Amniotic constriction ring (HP:0009775)2.13885364
84Abnormality of placental membranes (HP:0011409)2.13885364
85Methylmalonic acidemia (HP:0002912)2.13059874
86Muscle fiber inclusion bodies (HP:0100299)2.12471789
87Prolonged QT interval (HP:0001657)2.12225533
88Absent septum pellucidum (HP:0001331)2.11011387
89Intestinal atresia (HP:0011100)2.09132091
90Supernumerary spleens (HP:0009799)2.08823328
91Megalencephaly (HP:0001355)2.08048333
92Dysmetric saccades (HP:0000641)2.06954380
93Myotonia (HP:0002486)2.06352869
94Lissencephaly (HP:0001339)2.05583184
95Broad foot (HP:0001769)2.05109708
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03844059
97Acute encephalopathy (HP:0006846)2.02918432
98Progressive macrocephaly (HP:0004481)2.02896178
99Lower limb muscle weakness (HP:0007340)2.01181716
100Pendular nystagmus (HP:0012043)2.00502683
101Hypoventilation (HP:0002791)1.98038610
102Abnormality of glycine metabolism (HP:0010895)1.97570467
103Abnormality of serine family amino acid metabolism (HP:0010894)1.97570467
104Shoulder girdle muscle weakness (HP:0003547)1.97137228
105Ventricular fibrillation (HP:0001663)1.97100110
106Exercise-induced myalgia (HP:0003738)1.96916498
107Poor suck (HP:0002033)1.95243704
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.93983422
109Specific learning disability (HP:0001328)1.93800200
110Anosmia (HP:0000458)1.92720175
111Abnormal hair whorl (HP:0010721)1.92072883
112Spastic tetraplegia (HP:0002510)1.91787109
113Acute necrotizing encephalopathy (HP:0006965)1.91490757
114Abnormal mitochondria in muscle tissue (HP:0008316)1.90985451
115Focal dystonia (HP:0004373)1.90115668
116Congenital primary aphakia (HP:0007707)1.89326352
117Abnormality of serum amino acid levels (HP:0003112)1.89242256
118Syncope (HP:0001279)1.88594103
119Akinesia (HP:0002304)1.87791898
120Incomplete penetrance (HP:0003829)1.87334171
121Popliteal pterygium (HP:0009756)1.86761213
122Esophageal atresia (HP:0002032)1.86262445
123Abnormality of salivation (HP:0100755)1.85638436
124Optic nerve hypoplasia (HP:0000609)1.85635884
125Abnormality of the septum pellucidum (HP:0007375)1.83950058
126Craniofacial dystonia (HP:0012179)1.83327532
127Broad alveolar ridges (HP:0000187)1.82921390
128Amyotrophic lateral sclerosis (HP:0007354)1.82775511
129Abnormality of the ileum (HP:0001549)1.82431680
130Genital tract atresia (HP:0001827)1.81867964
131Retinal dysplasia (HP:0007973)1.81620508
132Decreased testicular size (HP:0008734)1.80942383
133Postural instability (HP:0002172)1.80519289
134Generalized myoclonic seizures (HP:0002123)1.80389568
135Meckel diverticulum (HP:0002245)1.78972997
136Exotropia (HP:0000577)1.77826275
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76804582
138Morphological abnormality of the pyramidal tract (HP:0002062)1.76771131
139Hyperglycinuria (HP:0003108)1.76513087
140Psychosis (HP:0000709)1.76163168
141Abnormality of pain sensation (HP:0010832)1.75642389
142Impaired pain sensation (HP:0007328)1.75642389
143Gastrointestinal atresia (HP:0002589)1.75189738
144Pancreatic islet-cell hyperplasia (HP:0004510)1.74680016
145Cerebral inclusion bodies (HP:0100314)1.74568865
146Neoplasm of the peripheral nervous system (HP:0100007)1.74461770
147Medial flaring of the eyebrow (HP:0010747)1.74385954
148Stenosis of the external auditory canal (HP:0000402)1.73871528
149Muscle fiber atrophy (HP:0100295)1.72730869
150Depressed nasal tip (HP:0000437)1.70773479
151Renal hypoplasia (HP:0000089)1.70545892
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70100094
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70100094
154Mitochondrial inheritance (HP:0001427)1.68901928
155Abolished electroretinogram (ERG) (HP:0000550)1.65408127
156Labial hypoplasia (HP:0000066)1.64368159
157Hypoplastic female external genitalia (HP:0012815)1.63593974
158Breast aplasia (HP:0100783)1.62258069
159Abnormal lung lobation (HP:0002101)1.59227556
160Bifid tongue (HP:0010297)1.59018270
161Abnormality of the musculature of the pelvis (HP:0001469)1.58994162
162Abnormality of the hip-girdle musculature (HP:0001445)1.58994162
163Megaloblastic anemia (HP:0001889)1.58699637
164Abnormality of the neuromuscular junction (HP:0003398)1.58415863
165Fatigable weakness (HP:0003473)1.58415863
166Cortical dysplasia (HP:0002539)1.58068452
167Neoplasm of the adrenal gland (HP:0100631)1.56942710
168Cupped ear (HP:0000378)1.56657800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.98836875
2MARK13.60278095
3MAP3K43.25043758
4NTRK33.13160697
5PBK3.03194616
6MINK12.96439973
7MAP2K72.78946764
8MAP3K122.76438728
9CASK2.74552410
10KSR22.52792049
11MKNK22.40539092
12EPHA42.26178944
13ARAF2.19889932
14PAK62.16046939
15PHKG22.13833111
16PHKG12.13833111
17MAP2K42.12762948
18OBSCN2.10359155
19NTRK12.04211293
20TSSK61.97800342
21MAPK131.87373321
22BMPR1B1.86658382
23LATS21.78976595
24KSR11.77701837
25MKNK11.68708189
26BUB11.68635598
27DAPK21.67826604
28TNIK1.66660327
29PLK31.64884475
30FGFR21.57974243
31NTRK21.55824460
32NUAK11.54291091
33NME11.54015756
34SRPK11.51369398
35GRK51.46723386
36PNCK1.45161287
37TRIM281.43625642
38CDC71.39472397
39OXSR11.29300014
40PLK41.25827733
41MAP3K131.25391873
42VRK21.24744336
43LMTK21.23835512
44CDK51.22239204
45PLK21.21678295
46CSNK1G11.20537260
47GRK71.18444269
48VRK11.16027073
49DYRK31.15860148
50MAP3K61.12126442
51PRPF4B1.11036283
52CSNK1G21.09096605
53RAF11.08781725
54NEK11.07782555
55PAK31.06198079
56MAP3K21.01683236
57ZAK0.96675803
58CAMK2A0.93578529
59TTK0.93422541
60FRK0.91707692
61RET0.91552757
62CDK140.91120404
63GRK10.89136159
64PRKCG0.87823632
65PLK10.87652619
66BRAF0.86966994
67FGFR10.86409975
68DYRK20.86026977
69INSRR0.85997267
70CCNB10.85746791
71TAF10.85516270
72MAP2K10.84493563
73DAPK10.84438546
74CAMK2D0.83498744
75CDK180.83310122
76ERBB30.80712887
77SGK2230.80522912
78SGK4940.80522912
79CDK150.80342399
80UHMK10.77321810
81SIK20.76140620
82CAMKK10.76009763
83FES0.74616506
84DYRK1A0.72690453
85CSNK1G30.71922401
86STK380.71831782
87PRKCE0.70458542
88FER0.69647572
89CDK190.69071923
90RIPK40.68872356
91PRKD30.68307004
92CDK11A0.68166998
93SCYL20.67875433
94LIMK10.67098525
95CSNK1E0.64706760
96MAP3K10.63813549
97MAPKAPK30.63082363
98BMPR20.62123362
99CAMKK20.61318119
100MOS0.57217667
101LATS10.56476970
102MARK20.55079109
103SGK20.54588971
104ALK0.54364357
105WNK30.53413738
106ADRBK10.53092013
107MUSK0.52925060
108RPS6KA40.52622977
109EIF2AK30.51655328
110PINK10.50595442
111RPS6KA20.49594697
112WNK10.48541154
113PRKG10.48418402
114ADRBK20.47783144
115STK110.47735221
116CAMK2B0.46348820
117TGFBR10.45768484
118STK160.45164644
119MAP4K20.44797877
120TAOK10.44769105
121ATM0.44041994
122BCR0.43006947
123PRKDC0.42919337
124PRKACB0.41869775
125CDK80.41401437
126MAPKAPK50.41224100
127MAP3K70.41192062
128CAMK2G0.40856718
129AKT30.40812670
130CSNK1A1L0.40778276
131CSNK1D0.40763621
132PRKCZ0.39953082
133DYRK1B0.39017144
134PRKAA10.38681870
135ROCK20.37556330
136PRKCH0.36250989
137PRKACA0.35993940
138STK38L0.35978074
139PDK40.35490588
140PDK30.35490588
141CDK30.35080956
142TIE10.34861849
143TNK20.33958095
144CAMK10.33563201

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.75591302
2Nicotine addiction_Homo sapiens_hsa050333.32582438
3Olfactory transduction_Homo sapiens_hsa047403.07077201
4GABAergic synapse_Homo sapiens_hsa047272.86036673
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72103479
6Morphine addiction_Homo sapiens_hsa050322.55196654
7Circadian entrainment_Homo sapiens_hsa047132.41064381
8Dopaminergic synapse_Homo sapiens_hsa047282.27073406
9Glutamatergic synapse_Homo sapiens_hsa047242.24689109
10Taste transduction_Homo sapiens_hsa047422.14835544
11Serotonergic synapse_Homo sapiens_hsa047262.06876130
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05153080
13Cholinergic synapse_Homo sapiens_hsa047252.02194638
14Long-term potentiation_Homo sapiens_hsa047201.97212851
15Insulin secretion_Homo sapiens_hsa049111.94734937
16Collecting duct acid secretion_Homo sapiens_hsa049661.88067728
17RNA polymerase_Homo sapiens_hsa030201.82333899
18Amphetamine addiction_Homo sapiens_hsa050311.81352700
19Salivary secretion_Homo sapiens_hsa049701.76689085
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75518486
21Renin secretion_Homo sapiens_hsa049241.67850657
22Protein export_Homo sapiens_hsa030601.62833219
23beta-Alanine metabolism_Homo sapiens_hsa004101.60552738
24Cocaine addiction_Homo sapiens_hsa050301.58237850
25Long-term depression_Homo sapiens_hsa047301.56402049
26Steroid biosynthesis_Homo sapiens_hsa001001.56210640
27Oxytocin signaling pathway_Homo sapiens_hsa049211.52288277
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51221053
29Proteasome_Homo sapiens_hsa030501.51116109
30Gastric acid secretion_Homo sapiens_hsa049711.50736647
31Basal transcription factors_Homo sapiens_hsa030221.46723441
32Phototransduction_Homo sapiens_hsa047441.41277831
33Cardiac muscle contraction_Homo sapiens_hsa042601.40918799
34Mismatch repair_Homo sapiens_hsa034301.40599713
35Gap junction_Homo sapiens_hsa045401.40451716
36Oxidative phosphorylation_Homo sapiens_hsa001901.40378055
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39883768
38GnRH signaling pathway_Homo sapiens_hsa049121.38131777
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34588075
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32171892
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31623465
42Parkinsons disease_Homo sapiens_hsa050121.29628754
43Spliceosome_Homo sapiens_hsa030401.29546517
44RNA transport_Homo sapiens_hsa030131.28448242
45RNA degradation_Homo sapiens_hsa030181.28136813
46Calcium signaling pathway_Homo sapiens_hsa040201.27826007
47Propanoate metabolism_Homo sapiens_hsa006401.27237305
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24572748
49Vibrio cholerae infection_Homo sapiens_hsa051101.20840475
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14157159
51Alzheimers disease_Homo sapiens_hsa050101.12664916
52Axon guidance_Homo sapiens_hsa043601.10781617
53Estrogen signaling pathway_Homo sapiens_hsa049151.08746305
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08558100
55* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08544982
56Type II diabetes mellitus_Homo sapiens_hsa049301.08436427
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07994925
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07058448
59cAMP signaling pathway_Homo sapiens_hsa040241.04494188
60Non-homologous end-joining_Homo sapiens_hsa034501.01903957
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00323848
62mRNA surveillance pathway_Homo sapiens_hsa030150.98948115
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98409682
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.97803764
65ErbB signaling pathway_Homo sapiens_hsa040120.95465218
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94337845
67Glioma_Homo sapiens_hsa052140.94221499
68Pyruvate metabolism_Homo sapiens_hsa006200.92380004
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90805775
70Homologous recombination_Homo sapiens_hsa034400.90593385
71Oocyte meiosis_Homo sapiens_hsa041140.90430225
72One carbon pool by folate_Homo sapiens_hsa006700.90358791
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89930184
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89602476
75Fanconi anemia pathway_Homo sapiens_hsa034600.88816837
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88656864
77Dorso-ventral axis formation_Homo sapiens_hsa043200.87143989
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85242009
79Melanogenesis_Homo sapiens_hsa049160.85041656
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.84893938
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84506376
82Nucleotide excision repair_Homo sapiens_hsa034200.83200290
83Purine metabolism_Homo sapiens_hsa002300.82098083
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81513236
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78395499
86Circadian rhythm_Homo sapiens_hsa047100.76513105
87Dilated cardiomyopathy_Homo sapiens_hsa054140.75797755
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74798007
89Huntingtons disease_Homo sapiens_hsa050160.74532527
90Wnt signaling pathway_Homo sapiens_hsa043100.73357689
91Hippo signaling pathway_Homo sapiens_hsa043900.71626952
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.71312960
93Endometrial cancer_Homo sapiens_hsa052130.71085026
94Cell cycle_Homo sapiens_hsa041100.70358494
95Tight junction_Homo sapiens_hsa045300.70317321
96Ribosome_Homo sapiens_hsa030100.69568272
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69187105
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68858075
99Colorectal cancer_Homo sapiens_hsa052100.67808185
100Alcoholism_Homo sapiens_hsa050340.67505893
101DNA replication_Homo sapiens_hsa030300.67329614
102Basal cell carcinoma_Homo sapiens_hsa052170.66460055
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66298786
104Base excision repair_Homo sapiens_hsa034100.64740220
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64246725
106MAPK signaling pathway_Homo sapiens_hsa040100.63640705
107Butanoate metabolism_Homo sapiens_hsa006500.63588733
108Biosynthesis of amino acids_Homo sapiens_hsa012300.63015936
109Insulin signaling pathway_Homo sapiens_hsa049100.62806220
110Fatty acid metabolism_Homo sapiens_hsa012120.62358781
111Glucagon signaling pathway_Homo sapiens_hsa049220.62129980
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61470429
113Pancreatic secretion_Homo sapiens_hsa049720.60892445
114Choline metabolism in cancer_Homo sapiens_hsa052310.60723758
115Ras signaling pathway_Homo sapiens_hsa040140.59516870
116Carbon metabolism_Homo sapiens_hsa012000.58644271
117Ovarian steroidogenesis_Homo sapiens_hsa049130.58039057
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56595895
119VEGF signaling pathway_Homo sapiens_hsa043700.55316292
120Vitamin digestion and absorption_Homo sapiens_hsa049770.54010221
121Hedgehog signaling pathway_Homo sapiens_hsa043400.53917042
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53584412
123Arginine and proline metabolism_Homo sapiens_hsa003300.52837016
124Fatty acid elongation_Homo sapiens_hsa000620.52065422
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51765280
126Metabolic pathways_Homo sapiens_hsa011000.50723459
127Vitamin B6 metabolism_Homo sapiens_hsa007500.50352568
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49743197
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.49520856
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.49426865
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49209585
132Selenocompound metabolism_Homo sapiens_hsa004500.47668795
133Fatty acid biosynthesis_Homo sapiens_hsa000610.47506096
134Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47335421
135Renal cell carcinoma_Homo sapiens_hsa052110.46718002
136Thyroid hormone synthesis_Homo sapiens_hsa049180.46367687
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45951758
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.45191767
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44678575
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44567532
141Melanoma_Homo sapiens_hsa052180.44565793
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44027620
143Prolactin signaling pathway_Homo sapiens_hsa049170.43869547
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42712060
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42072955
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37775821
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37522004
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35836531
149Inositol phosphate metabolism_Homo sapiens_hsa005620.35238440
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34962222
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34929945
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33017506
153mTOR signaling pathway_Homo sapiens_hsa041500.32757528
154Type I diabetes mellitus_Homo sapiens_hsa049400.32258789
155Rap1 signaling pathway_Homo sapiens_hsa040150.31935116

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