HS3ST6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primary alcohol catabolic process (GO:0034310)8.67005983
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.66939231
3epithelial cilium movement (GO:0003351)8.54267668
4axoneme assembly (GO:0035082)8.03864656
5glomerular visceral epithelial cell development (GO:0072015)7.91413134
6left/right pattern formation (GO:0060972)7.25293471
7glomerular epithelial cell development (GO:0072310)6.94620261
8ethanol metabolic process (GO:0006067)6.48554152
9keratinization (GO:0031424)6.35762220
10COPI coating of Golgi vesicle (GO:0048205)6.09486812
11Golgi transport vesicle coating (GO:0048200)6.09486812
12glomerular basement membrane development (GO:0032836)5.78392619
13desmosome organization (GO:0002934)5.73131762
14lung epithelium development (GO:0060428)5.63306481
15negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.54592499
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.28645463
17exocrine pancreas development (GO:0031017)5.11629179
18endocrine pancreas development (GO:0031018)5.10665978
19keratinocyte proliferation (GO:0043616)5.05260824
20protein retention in ER lumen (GO:0006621)5.01444975
21one-carbon compound transport (GO:0019755)4.96513037
22microtubule bundle formation (GO:0001578)4.94606867
23diterpenoid biosynthetic process (GO:0016102)4.85328788
24negative regulation of T cell differentiation in thymus (GO:0033085)4.75412855
25establishment of apical/basal cell polarity (GO:0035089)4.71532732
26peptide hormone processing (GO:0016486)4.66677269
27regulation of retinoic acid receptor signaling pathway (GO:0048385)4.58129080
28left/right axis specification (GO:0070986)4.41810792
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.41015183
30negative regulation of B cell mediated immunity (GO:0002713)4.40713934
31negative regulation of immunoglobulin mediated immune response (GO:0002890)4.40713934
32regulation of cilium movement (GO:0003352)4.40394290
33establishment or maintenance of monopolar cell polarity (GO:0061339)4.39057465
34establishment of monopolar cell polarity (GO:0061162)4.39057465
35glandular epithelial cell differentiation (GO:0002067)4.34303305
36COPII vesicle coating (GO:0048208)4.30934858
37vitamin transmembrane transport (GO:0035461)4.29895621
38hair cycle (GO:0042633)4.25376363
39molting cycle (GO:0042303)4.25376363
40regulation of type B pancreatic cell apoptotic process (GO:2000674)4.14140978
41glomerulus development (GO:0032835)4.10670941
42pyrimidine-containing compound transmembrane transport (GO:0072531)4.03818922
43glucosamine-containing compound catabolic process (GO:1901072)4.01170922
44phosphate ion transmembrane transport (GO:0035435)3.99895517
45regulation of water loss via skin (GO:0033561)3.94550202
46protein maturation by protein folding (GO:0022417)3.83858067
47hemidesmosome assembly (GO:0031581)3.82745067
48ventricular system development (GO:0021591)3.82059359
49cilium organization (GO:0044782)3.79151616
50negative regulation of glycoprotein biosynthetic process (GO:0010561)3.78974833
51regulation of phospholipase A2 activity (GO:0032429)3.73351543
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.72247689
53cilium assembly (GO:0042384)3.68765088
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.67788651
55tolerance induction (GO:0002507)3.65993281
56intraciliary transport (GO:0042073)3.64897599
57response to xenobiotic stimulus (GO:0009410)3.58194874
58establishment of planar polarity (GO:0001736)3.56910992
59establishment of tissue polarity (GO:0007164)3.56910992
60proline transport (GO:0015824)3.55936658
61primary alcohol metabolic process (GO:0034308)3.55073159
62lipoxygenase pathway (GO:0019372)3.53523167
63regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.53306727
64establishment of skin barrier (GO:0061436)3.53161888
65lens fiber cell development (GO:0070307)3.51481215
66activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.51188095
67keratinocyte development (GO:0003334)3.49091675
68multicellular organismal water homeostasis (GO:0050891)3.48252551
69long-chain fatty acid biosynthetic process (GO:0042759)3.45403747
70gland morphogenesis (GO:0022612)3.43797344
71keratinocyte differentiation (GO:0030216)3.42834369
72positive regulation of insulin secretion (GO:0032024)3.42194477
73retinoic acid metabolic process (GO:0042573)3.41487178
74glandular epithelial cell development (GO:0002068)3.41313219
75ethanol oxidation (GO:0006069)3.39822875
76positive regulation of transcription regulatory region DNA binding (GO:2000679)3.38997860
77signal peptide processing (GO:0006465)3.38393444
78terpenoid biosynthetic process (GO:0016114)3.37197828
79phosphate ion transport (GO:0006817)3.37132497
80negative regulation of humoral immune response (GO:0002921)3.35190136
81microtubule-based movement (GO:0007018)3.32660788
82peptide cross-linking (GO:0018149)3.29642162
83epidermis development (GO:0008544)3.29418197
84positive regulation of nuclease activity (GO:0032075)3.27233203
85regulation of germinal center formation (GO:0002634)3.25225129
86embryonic camera-type eye development (GO:0031076)3.23328733
87regulation of apoptotic process involved in morphogenesis (GO:1902337)3.22940921
884-hydroxyproline metabolic process (GO:0019471)3.20859534
89phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.20659211
90columnar/cuboidal epithelial cell development (GO:0002066)3.20330564
91regulation of endothelial cell chemotaxis (GO:2001026)3.19999671
92regulation of microtubule-based movement (GO:0060632)3.17253619
93excretion (GO:0007588)3.16680873
94regulation of cell proliferation involved in kidney development (GO:1901722)3.13031082
95negative regulation of keratinocyte proliferation (GO:0010839)3.12793842
96insulin secretion (GO:0030073)3.11980953
97intermediate filament organization (GO:0045109)3.11975216
98lateral sprouting from an epithelium (GO:0060601)3.11585636
99type B pancreatic cell development (GO:0003323)3.11086002
100positive regulation of gastrulation (GO:2000543)3.09317759
101epithelial cell fate commitment (GO:0072148)3.07302814
102retinol metabolic process (GO:0042572)3.05967148
103sphingoid metabolic process (GO:0046519)3.04478384
104intestinal cholesterol absorption (GO:0030299)3.02392635
105centriole assembly (GO:0098534)3.00885914
106synaptonemal complex assembly (GO:0007130)2.96771541
107pharyngeal system development (GO:0060037)2.96542346
108intestinal epithelial cell development (GO:0060576)2.96129821
109cytoplasmic microtubule organization (GO:0031122)2.95023878
110SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93264383
111sphingosine metabolic process (GO:0006670)2.92536856
112cellular component assembly involved in morphogenesis (GO:0010927)2.91519414
113regulation of insulin secretion (GO:0050796)2.91127114
114regulation of cholesterol homeostasis (GO:2000188)2.90831905
115protein targeting to ER (GO:0045047)2.89918840
116regulation of nuclease activity (GO:0032069)2.89835507
117negative regulation of glycoprotein metabolic process (GO:1903019)2.89632544
118water homeostasis (GO:0030104)2.89453829
119cerebellar granule cell differentiation (GO:0021707)2.89401506
120cell projection assembly (GO:0030031)2.89219280
121nitric oxide mediated signal transduction (GO:0007263)2.88314511
122induction of positive chemotaxis (GO:0050930)2.86129074
123regulation of mesonephros development (GO:0061217)2.85933942
124membrane budding (GO:0006900)2.85085303
125cotranslational protein targeting to membrane (GO:0006613)2.84715323
126endoplasmic reticulum unfolded protein response (GO:0030968)2.84534453
127dopaminergic neuron differentiation (GO:0071542)2.83926697
128sperm capacitation (GO:0048240)2.83823308
129protein-cofactor linkage (GO:0018065)2.80526595
130establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78926688
131cellular response to unfolded protein (GO:0034620)2.77158890
132mesenchymal to epithelial transition (GO:0060231)2.76442400
133hydrogen peroxide biosynthetic process (GO:0050665)2.76166419
134cellular response to vitamin D (GO:0071305)2.74369305
135regulation of interleukin-5 production (GO:0032674)2.74318818
136ER overload response (GO:0006983)2.74295370
137regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.73899137
138ER-nucleus signaling pathway (GO:0006984)2.73187293
139regulation of cardioblast proliferation (GO:0003264)2.73062444
140regulation of secondary heart field cardioblast proliferation (GO:0003266)2.73062444
141positive regulation of peptide hormone secretion (GO:0090277)2.72769289
142protein localization to cilium (GO:0061512)2.71995639
143L-phenylalanine catabolic process (GO:0006559)2.71298899
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71298899
145gamma-aminobutyric acid transport (GO:0015812)2.70861329
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70426888
147sympathetic nervous system development (GO:0048485)2.70222116
148regulation of ruffle assembly (GO:1900027)2.69127626
149protein localization to endoplasmic reticulum (GO:0070972)2.68570447
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.67138994
151L-phenylalanine metabolic process (GO:0006558)2.67138994
152cranial nerve development (GO:0021545)2.66865083
153cellular response to topologically incorrect protein (GO:0035967)2.66791411
154epidermal cell differentiation (GO:0009913)2.66276762
155regulation of peptide hormone secretion (GO:0090276)2.64591286
156centrosome localization (GO:0051642)2.64262444
157purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.63952045
1583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.63952045
159negative regulation of inclusion body assembly (GO:0090084)2.62873281
160regulation of glomerulus development (GO:0090192)2.62064247
161positive regulation of tolerance induction (GO:0002645)2.61731266
162sodium ion homeostasis (GO:0055078)2.61494324
163interferon-gamma secretion (GO:0072643)2.60576278
164positive regulation of peptide secretion (GO:0002793)2.60196787
165regulation of interleukin-13 production (GO:0032656)2.59889790
166synaptonemal complex organization (GO:0070193)2.59771953
167regulation of peptide secretion (GO:0002791)2.58027335
168regulation of cilium assembly (GO:1902017)2.57912907
169morphogenesis of embryonic epithelium (GO:0016331)2.57548069
170norepinephrine metabolic process (GO:0042415)2.57523692
171coronary vasculature morphogenesis (GO:0060977)2.56406920
172response to dietary excess (GO:0002021)2.56345269
173cilium morphogenesis (GO:0060271)2.55409718
174regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54298222
175regulation of keratinocyte proliferation (GO:0010837)2.52830253
176negative regulation of kidney development (GO:0090185)2.52772010
177dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51279775
178positive regulation of glomerulus development (GO:0090193)2.51108566
179exogenous drug catabolic process (GO:0042738)2.50863025
180vesicle coating (GO:0006901)2.50790631
181regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.50371315
182diol metabolic process (GO:0034311)2.49355182
183regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.47056964
184ear development (GO:0043583)2.43280508
185reactive oxygen species biosynthetic process (GO:1903409)2.42515747
186renal system development (GO:0072001)2.42465258
187transmission of nerve impulse (GO:0019226)2.42221800
188regulation of transforming growth factor beta1 production (GO:0032908)2.41576413
189axonemal dynein complex assembly (GO:0070286)14.6224046
190cilium or flagellum-dependent cell motility (GO:0001539)12.2522574
191motile cilium assembly (GO:0044458)10.6687113
192cilium movement (GO:0003341)10.2358731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.34579233
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65591649
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.49083207
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.06945966
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01991316
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.71687989
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.50114814
8* SMC4_20622854_ChIP-Seq_HELA_Human2.23740637
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20702939
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.13474836
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.07412524
12P63_26484246_Chip-Seq_KERATINOCYTES_Human2.07095181
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02651624
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01279057
15TP63_17297297_ChIP-ChIP_HaCaT_Human10.6850140
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92539692
17CLOCK_20551151_ChIP-Seq_293T_Human1.90685073
18* P68_20966046_ChIP-Seq_HELA_Human1.90444847
19ZNF263_19887448_ChIP-Seq_K562_Human1.89909949
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84808747
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81166949
22* STAT1_20625510_ChIP-Seq_HELA_Human1.80993253
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.76648338
24* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.74641696
25CTCF_20526341_ChIP-Seq_ESCs_Human1.71989941
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66710545
27DROSHA_22980978_ChIP-Seq_HELA_Human1.64398517
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63266560
29* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60187257
30* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54312421
31SOX2_20726797_ChIP-Seq_SW620_Human1.54311169
32GATA1_22025678_ChIP-Seq_K562_Human1.52116068
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47447394
34* PHF8_20622854_ChIP-Seq_HELA_Human1.47211313
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47019063
36* BCOR_27268052_Chip-Seq_Bcells_Human1.45668294
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.44509907
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.42354332
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.42337892
40* RUNX1_27514584_Chip-Seq_MCF-7_Human1.42023167
41GATA4_25053715_ChIP-Seq_YYC3_Human1.39206488
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39116427
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39037176
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37888853
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37700941
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37045496
47CREB1_26743006_Chip-Seq_LNCaP_Human1.35891269
48* ELF1_20517297_ChIP-Seq_JURKAT_Human1.34791495
49* E2F1_20622854_ChIP-Seq_HELA_Human1.32238622
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30872703
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30794315
52* TP53_20018659_ChIP-ChIP_R1E_Mouse1.29578296
53* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29015552
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28249861
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28093613
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27573262
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.26729180
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23494308
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.23459755
60TET1_21490601_ChIP-Seq_MESCs_Mouse1.21575596
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21281713
62SA1_27219007_Chip-Seq_Bcells_Human1.20820947
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.20064813
64* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18647143
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18139123
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18096868
67BCL6_27268052_Chip-Seq_Bcells_Human1.17332509
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16191811
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14236615
70LXR_22292898_ChIP-Seq_THP-1_Human1.14181988
71* P300_27268052_Chip-Seq_Bcells_Human1.13943616
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13354950
73OCT4_19829295_ChIP-Seq_ESCs_Human1.10860754
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10237116
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08776284
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08658288
77* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08394508
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08282951
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.08079494
80ERA_21632823_ChIP-Seq_H3396_Human1.08000379
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07898091
82* YY1_22570637_ChIP-Seq_MALME-3M_Human1.07596387
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07259538
84TP63_22573176_ChIP-Seq_HFKS_Human1.07159284
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06528042
86* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05328291
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04735955
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04732899
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03288790
90RACK7_27058665_Chip-Seq_MCF-7_Human1.02800537
91SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02461581
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02314637
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02007513
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01278965
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01278965
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.01002585
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00519911
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00468778
99CJUN_26792858_Chip-Seq_BT549_Human1.00061695
100RNF2_27304074_Chip-Seq_ESCs_Mouse0.98829624
101* SOX2_21211035_ChIP-Seq_LN229_Human0.98469042
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.98203739
103* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97494957
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97307299
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95731908
106AHR_22903824_ChIP-Seq_MCF-7_Human0.95422316
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95115395
108FLI1_21867929_ChIP-Seq_CD8_Mouse0.94206411
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.92947808
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92106924
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91941909
112* CTCF_27219007_Chip-Seq_Bcells_Human0.90908238
113* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90325866
114GATA6_25053715_ChIP-Seq_YYC3_Human0.89839149
115P53_21459846_ChIP-Seq_SAOS-2_Human0.89533149
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89529225
117KDM2B_26808549_Chip-Seq_K562_Human0.89521335
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.89395018
119TP63_23658742_ChIP-Seq_EP156T_Human0.88278575
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.88194327
121RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87503484
122EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87503484
123* RARB_24833708_ChIP-Seq_LIVER_Mouse0.87220895
124* KLF5_25053715_ChIP-Seq_YYC3_Human0.87122915
125SMRT_27268052_Chip-Seq_Bcells_Human0.86336818
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86194301
127* RAC3_21632823_ChIP-Seq_H3396_Human0.85806705
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85330921
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85191054
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84159177
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83562025
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.82746361
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.82746361
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.82504309
135* TP53_23651856_ChIP-Seq_MEFs_Mouse0.82421234
136BCAT_22108803_ChIP-Seq_LS180_Human0.82237421
137* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81329178
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.81172287
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79801246
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.79572985
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.78793226
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.78579062
143* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77351780
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77265931
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75420523
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74826317
147* RING1B_27294783_Chip-Seq_NPCs_Mouse0.73754615
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73357095
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.71573310
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.70769807
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70296067

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.40430690
2MP0008875_abnormal_xenobiotic_pharmacok4.31110049
3MP0002877_abnormal_melanocyte_morpholog3.60869319
4MP0003283_abnormal_digestive_organ3.45114263
5MP0003195_calcinosis3.24198810
6MP0000013_abnormal_adipose_tissue3.19495496
7MP0002796_impaired_skin_barrier3.18307468
8MP0002254_reproductive_system_inflammat2.93235899
9MP0004043_abnormal_pH_regulation2.92986896
10MP0000678_abnormal_parathyroid_gland2.88387741
11MP0001944_abnormal_pancreas_morphology2.58421424
12MP0010386_abnormal_urinary_bladder2.55271152
13MP0002693_abnormal_pancreas_physiology2.53792134
14MP0004133_heterotaxia2.53492418
15MP0006072_abnormal_retinal_apoptosis2.34240639
16MP0004381_abnormal_hair_follicle2.33398902
17MP0005220_abnormal_exocrine_pancreas2.33145463
18MP0001346_abnormal_lacrimal_gland2.29509150
19MP0005623_abnormal_meninges_morphology2.15215138
20MP0005379_endocrine/exocrine_gland_phen2.12878592
21MP0002060_abnormal_skin_morphology2.12871943
22MP0002098_abnormal_vibrissa_morphology2.12476151
23MP0002909_abnormal_adrenal_gland2.07749122
24MP0000383_abnormal_hair_follicle2.07036075
25MP0000003_abnormal_adipose_tissue1.99950297
26MP0009780_abnormal_chondrocyte_physiolo1.96894849
27MP0003878_abnormal_ear_physiology1.94568695
28MP0005377_hearing/vestibular/ear_phenot1.94568695
29MP0001502_abnormal_circadian_rhythm1.89183007
30MP0005365_abnormal_bile_salt1.86383523
31MP0000579_abnormal_nail_morphology1.84454234
32MP0002132_abnormal_respiratory_system1.82705725
33MP0002009_preneoplasia1.81721748
34MP0008961_abnormal_basal_metabolism1.76486269
35MP0010234_abnormal_vibrissa_follicle1.74418747
36MP0010030_abnormal_orbit_morphology1.72472037
37MP0000462_abnormal_digestive_system1.70290031
38MP0002653_abnormal_ependyma_morphology1.67511112
39MP0009643_abnormal_urine_homeostasis1.64659784
40MP0010678_abnormal_skin_adnexa1.61449662
41MP0005501_abnormal_skin_physiology1.58411296
42MP0001216_abnormal_epidermal_layer1.56220415
43MP0000613_abnormal_salivary_gland1.53989162
44MP0005499_abnormal_olfactory_system1.52004159
45MP0005394_taste/olfaction_phenotype1.52004159
46MP0003045_fibrosis1.47638939
47MP0003123_paternal_imprinting1.45153933
48MP0008995_early_reproductive_senescence1.44984045
49MP0000467_abnormal_esophagus_morphology1.44142865
50MP0003453_abnormal_keratinocyte_physiol1.41285265
51MP0001666_abnormal_nutrient_absorption1.37801849
52MP0002249_abnormal_larynx_morphology1.36446631
53MP0002234_abnormal_pharynx_morphology1.36257911
54MP0005165_increased_susceptibility_to1.35327453
55MP0003942_abnormal_urinary_system1.30576575
56MP0002078_abnormal_glucose_homeostasis1.29457027
57MP0003787_abnormal_imprinting1.27067266
58MP0002837_dystrophic_cardiac_calcinosis1.26886184
59MP0000566_synostosis1.26582449
60MP0000762_abnormal_tongue_morphology1.25068579
61MP0003011_delayed_dark_adaptation1.24633134
62MP0001756_abnormal_urination1.24485842
63MP0000647_abnormal_sebaceous_gland1.24273874
64MP0001765_abnormal_ion_homeostasis1.23518610
65MP0000538_abnormal_urinary_bladder1.21094450
66MP0002139_abnormal_hepatobiliary_system1.20274020
67MP0005023_abnormal_wound_healing1.19018861
68MP0010771_integument_phenotype1.18038830
69MP0004264_abnormal_extraembryonic_tissu1.16558451
70MP0002896_abnormal_bone_mineralization1.15857025
71MP0002168_other_aberrant_phenotype1.14811301
72MP0004272_abnormal_basement_membrane1.13342314
73MP0003705_abnormal_hypodermis_morpholog1.09608535
74MP0003566_abnormal_cell_adhesion1.07685843
75MP0005085_abnormal_gallbladder_physiolo1.07240664
76MP0002876_abnormal_thyroid_physiology1.05782518
77MP0009384_cardiac_valve_regurgitation1.00929702
78MP0001984_abnormal_olfaction1.00548158
79MP0001270_distended_abdomen1.00452448
80MP0009046_muscle_twitch0.99758537
81MP0005187_abnormal_penis_morphology0.99129795
82MP0002638_abnormal_pupillary_reflex0.98750966
83MP0005076_abnormal_cell_differentiation0.98662299
84MP0003183_abnormal_peptide_metabolism0.98549875
85MP0005083_abnormal_biliary_tract0.97795256
86MP0003119_abnormal_digestive_system0.97761318
87MP0004859_abnormal_synaptic_plasticity0.95426947
88MP0002163_abnormal_gland_morphology0.93088626
89MP0005275_abnormal_skin_tensile0.92868547
90MP0001188_hyperpigmentation0.92050330
91MP0000534_abnormal_ureter_morphology0.91501642
92MP0009379_abnormal_foot_pigmentation0.91412572
93MP0008789_abnormal_olfactory_epithelium0.88931644
94MP0000230_abnormal_systemic_arterial0.88364359
95MP0000427_abnormal_hair_cycle0.87396414
96MP0001905_abnormal_dopamine_level0.87216733
97MP0004185_abnormal_adipocyte_glucose0.86923426
98MP0003953_abnormal_hormone_level0.86423934
99MP0002282_abnormal_trachea_morphology0.85549307
100MP0003879_abnormal_hair_cell0.85171338
101MP0001340_abnormal_eyelid_morphology0.83835215
102MP0001881_abnormal_mammary_gland0.83462374
103MP0004947_skin_inflammation0.83380576
104MP0000377_abnormal_hair_follicle0.82928492
105MP0002277_abnormal_respiratory_mucosa0.82898574
106MP0005375_adipose_tissue_phenotype0.82716338
107MP0004019_abnormal_vitamin_homeostasis0.82228689
108MP0004885_abnormal_endolymph0.82137720
109MP0003866_abnormal_defecation0.82068018
110MP0000470_abnormal_stomach_morphology0.81068625
111MP0005409_darkened_coat_color0.80488664
112MP0002160_abnormal_reproductive_system0.80360531
113MP0002177_abnormal_outer_ear0.80060278
114MP0001663_abnormal_digestive_system0.79967758
115MP0000049_abnormal_middle_ear0.79323000
116MP0005248_abnormal_Harderian_gland0.78945858
117MP0005332_abnormal_amino_acid0.78882989
118MP0005645_abnormal_hypothalamus_physiol0.78831503
119MP0002295_abnormal_pulmonary_circulatio0.77485745
120MP0004233_abnormal_muscle_weight0.76904560
121MP0000367_abnormal_coat/_hair0.76543927
122MP0001243_abnormal_dermal_layer0.75055359
123MP0005408_hypopigmentation0.74940137
124MP0000465_gastrointestinal_hemorrhage0.74918458
125MP0001919_abnormal_reproductive_system0.74598994
126MP0009931_abnormal_skin_appearance0.72778107
127MP0002233_abnormal_nose_morphology0.72598947
128MP0002136_abnormal_kidney_physiology0.71391484
129MP0000955_abnormal_spinal_cord0.71316659
130MP0002928_abnormal_bile_duct0.71315798
131MP0003938_abnormal_ear_development0.70606438
132MP0000639_abnormal_adrenal_gland0.70377703
133MP0001851_eye_inflammation0.68312320
134MP0003252_abnormal_bile_duct0.67773043
135MP0003959_abnormal_lean_body0.67053662
136MP0008260_abnormal_autophagy0.66740845
137MP0002735_abnormal_chemical_nociception0.66011524
138MP0002095_abnormal_skin_pigmentation0.65201297
139MP0002118_abnormal_lipid_homeostasis0.64910631
140MP0000163_abnormal_cartilage_morphology0.64402986
141MP0005395_other_phenotype0.62006656
142MP0004858_abnormal_nervous_system0.60679162
143MP0003075_altered_response_to0.60381812
144MP0005636_abnormal_mineral_homeostasis0.59629089
145MP0005381_digestive/alimentary_phenotyp0.58716311
146MP0000627_abnormal_mammary_gland0.56464475
147MP0004742_abnormal_vestibular_system0.54243492
148MP0001191_abnormal_skin_condition0.53399466
149MP0005386_behavior/neurological_phenoty0.49122319
150MP0004924_abnormal_behavior0.49122319
151MP0001849_ear_inflammation0.46980203
152MP0000681_abnormal_thyroid_gland0.46210218

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.39038190
2Abnormal respiratory epithelium morphology (HP:0012253)9.39038190
3Abnormal respiratory motile cilium physiology (HP:0012261)9.33069476
4Dynein arm defect of respiratory motile cilia (HP:0012255)9.05995144
5Absent/shortened dynein arms (HP:0200106)9.05995144
6Abnormal ciliary motility (HP:0012262)9.05055267
7Rhinitis (HP:0012384)8.71879611
8Bronchiectasis (HP:0002110)6.11720767
9Hyperinsulinemic hypoglycemia (HP:0000825)5.74482909
10Nasal polyposis (HP:0100582)5.70483129
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.46924490
12Hypoglycemic seizures (HP:0002173)5.19303373
13Hypoglycemic coma (HP:0001325)5.15383312
14Symptomatic seizures (HP:0011145)4.90302979
15Abnormality of the nasal mucosa (HP:0000433)4.64518121
16Mesangial abnormality (HP:0001966)4.55241878
17Lip pit (HP:0100267)4.26128849
18Abnormality of calcium-phosphate metabolism (HP:0100530)4.21822768
19Focal segmental glomerulosclerosis (HP:0000097)4.12763143
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69617653
21Hyperglycemia (HP:0003074)3.57426503
22Ketoacidosis (HP:0001993)3.56659414
23Recurrent sinusitis (HP:0011108)3.54496211
24Bronchitis (HP:0012387)3.43220099
25Insulin-resistant diabetes mellitus (HP:0000831)3.41497805
26Infertility (HP:0000789)3.41467732
27Hypoalbuminemia (HP:0003073)3.36819660
28Abnormal albumin level (HP:0012116)3.36819660
29Recurrent otitis media (HP:0000403)3.32137575
30Chronic sinusitis (HP:0011109)3.28478042
31Abnormal hemoglobin (HP:0011902)3.26114243
32Abnormal pancreas size (HP:0012094)3.25266613
33Mucopolysacchariduria (HP:0008155)3.13928166
34Urinary glycosaminoglycan excretion (HP:0003541)3.13928166
35Occipital encephalocele (HP:0002085)3.11920509
36Abnormality of endocrine pancreas physiology (HP:0012093)3.11224651
37Abnormality of the pancreatic islet cells (HP:0006476)3.11224651
38Glomerulosclerosis (HP:0000096)3.11177687
39Male infertility (HP:0003251)3.10925600
40Late onset (HP:0003584)3.07272190
41Abnormality of the intrinsic pathway (HP:0010989)3.05546099
42Pancreatic fibrosis (HP:0100732)3.05279186
43Abnormality of mucopolysaccharide metabolism (HP:0011020)3.02742047
44Abnormality of polysaccharide metabolism (HP:0011012)3.02742047
45Abnormality of glycosaminoglycan metabolism (HP:0004371)3.02742047
46Pancreatic islet-cell hyperplasia (HP:0004510)3.01699967
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.98417914
48Atelectasis (HP:0100750)2.94850535
49Absent eyebrow (HP:0002223)2.94267647
50Fragile nails (HP:0001808)2.93039299
51Split foot (HP:0001839)2.87659598
52True hermaphroditism (HP:0010459)2.85210112
53Generalized aminoaciduria (HP:0002909)2.80019368
54Chronic bronchitis (HP:0004469)2.75279017
55Pancreatic cysts (HP:0001737)2.72857974
56Increased IgE level (HP:0003212)2.71107742
57Dysostosis multiplex (HP:0000943)2.70202000
58Woolly hair (HP:0002224)2.70197393
59Congenital ichthyosiform erythroderma (HP:0007431)2.67124122
60Milia (HP:0001056)2.66545506
61Large for gestational age (HP:0001520)2.64615779
62Abdominal distention (HP:0003270)2.63502124
63Decreased circulating renin level (HP:0003351)2.62699811
64Plantar hyperkeratosis (HP:0007556)2.60382554
65Hyperparathyroidism (HP:0000843)2.54245767
66Hyperactive renin-angiotensin system (HP:0000841)2.53890247
67Corneal erosion (HP:0200020)2.51349189
68Conjugated hyperbilirubinemia (HP:0002908)2.49869558
69Cystic liver disease (HP:0006706)2.49775467
70Hypotrichosis (HP:0001006)2.42362949
71Onycholysis (HP:0001806)2.41555804
72Down-sloping shoulders (HP:0200021)2.40597427
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38723273
74Ketosis (HP:0001946)2.37697217
75Chronic otitis media (HP:0000389)2.37238656
76Agitation (HP:0000713)2.37181913
77Erythroderma (HP:0001019)2.32629164
78Insulin resistance (HP:0000855)2.30974112
79Hypokalemia (HP:0002900)2.29343091
80Pili torti (HP:0003777)2.26680916
81Type I diabetes mellitus (HP:0100651)2.26066564
82Bell-shaped thorax (HP:0001591)2.25530639
83Popliteal pterygium (HP:0009756)2.25030415
84Ankyloglossia (HP:0010296)2.22823330
85Hypophosphatemia (HP:0002148)2.21791513
86Myokymia (HP:0002411)2.20727516
87Gout (HP:0001997)2.20120693
88Right ventricular cardiomyopathy (HP:0011663)2.18257834
89Choanal stenosis (HP:0000452)2.18005870
90Turricephaly (HP:0000262)2.17671830
91Prolonged partial thromboplastin time (HP:0003645)2.17609231
92Abnormality of renin-angiotensin system (HP:0000847)2.16029763
93Ridged nail (HP:0001807)2.11739969
94Hypercortisolism (HP:0001578)2.11093025
95Renal salt wasting (HP:0000127)2.10408659
96Concave nail (HP:0001598)2.07723660
97Xanthomatosis (HP:0000991)2.07402962
98Hypokalemic alkalosis (HP:0001949)2.07147238
99Bifid scrotum (HP:0000048)2.03866859
100Palmar hyperkeratosis (HP:0010765)2.02384823
101Facial shape deformation (HP:0011334)2.01508281
102Potter facies (HP:0002009)2.01508281
103Hyperkalemia (HP:0002153)2.01115001
104Hypoplastic labia majora (HP:0000059)2.00547694
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8676017
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98948206
107Abnormal rod and cone electroretinograms (HP:0008323)1.97694849
108Erythema (HP:0010783)1.97677771
109Neonatal respiratory distress (HP:0002643)1.95965643
110Parakeratosis (HP:0001036)1.95148688
111Abnormality of potassium homeostasis (HP:0011042)1.92876562
112Male pseudohermaphroditism (HP:0000037)1.91746907
113Exocrine pancreatic insufficiency (HP:0001738)1.88193441
114Flat acetabular roof (HP:0003180)1.88088216
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87920640
116Hypoproteinemia (HP:0003075)1.87060057
117Anencephaly (HP:0002323)1.86370316
118Asplenia (HP:0001746)1.86196301
119Intestinal atresia (HP:0011100)1.85684084
120Osteomalacia (HP:0002749)1.85441702
121Absent eyelashes (HP:0000561)1.84843650
122Fibular aplasia (HP:0002990)1.84298448
123Growth hormone excess (HP:0000845)1.84007282
124Progressive neurologic deterioration (HP:0002344)1.83800567
125Humeroradial synostosis (HP:0003041)1.83433773
126Synostosis involving the elbow (HP:0003938)1.83433773
127Abnormality of midbrain morphology (HP:0002418)1.83150552
128Molar tooth sign on MRI (HP:0002419)1.83150552
129Thoracolumbar scoliosis (HP:0002944)1.83029242
130Atrophic scars (HP:0001075)1.82742592
131Abnormality of the common coagulation pathway (HP:0010990)1.82356378
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.82292341
133Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82246810
134Abnormality of the distal phalanges of the toes (HP:0010182)1.79860657
135Cutaneous finger syndactyly (HP:0010554)1.79255052
136Palmoplantar hyperkeratosis (HP:0000972)1.78843775
137Retinal atrophy (HP:0001105)1.77548453
138Abnormality of the labia majora (HP:0012881)1.77124583
139Furrowed tongue (HP:0000221)1.76768810
140Elevated alkaline phosphatase (HP:0003155)1.76043973
141Abnormality of the parathyroid morphology (HP:0011766)1.75898746
142Morphological abnormality of the middle ear (HP:0008609)1.73448121
143Limb hypertonia (HP:0002509)1.71980162
144Hyperaldosteronism (HP:0000859)1.71804183
145Nephritis (HP:0000123)1.71365946
146Eczematoid dermatitis (HP:0000976)1.71081155
147Abnormality of chloride homeostasis (HP:0011422)1.70378012
148Nephronophthisis (HP:0000090)1.69785969
149Septate vagina (HP:0001153)1.69644650
150Aplasia/hypoplasia of the uterus (HP:0008684)1.69166298
151Abnormality of the fovea (HP:0000493)1.68043842
152Renal dysplasia (HP:0000110)1.67069627
153Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66821920
154Abnormality of alkaline phosphatase activity (HP:0004379)1.66170126
155Stage 5 chronic kidney disease (HP:0003774)1.66059831
156Abnormality of nail color (HP:0100643)1.65612264
157Protuberant abdomen (HP:0001538)1.65162871
158Abnormality of the salivary glands (HP:0010286)1.64379731
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.64235938
160Abnormality of the vocal cords (HP:0008777)1.63687943
161Congenital hepatic fibrosis (HP:0002612)1.60923828
162Postaxial foot polydactyly (HP:0001830)1.60723946
163Tetany (HP:0001281)1.59057762
164Abnormal hair laboratory examination (HP:0003328)1.51896685
165Athetosis (HP:0002305)1.49879460
166Abnormality of the musculature of the hand (HP:0001421)1.48772765
167Ventricular fibrillation (HP:0001663)1.47849701
168Chronic hepatic failure (HP:0100626)1.47658252
169Sleep apnea (HP:0010535)1.45765467
170Vascular calcification (HP:0004934)1.45204813
171Gait imbalance (HP:0002141)1.43152898
172Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.42964584
173Abnormal blistering of the skin (HP:0008066)1.42945848
174Vaginal fistula (HP:0004320)1.42628703
175Carpal bone hypoplasia (HP:0001498)1.41264814
176Alopecia of scalp (HP:0002293)1.40755203
177Abnormality of permanent molar morphology (HP:0011071)1.40587014
178Abnormality of the dental root (HP:0006486)1.40587014
179Taurodontia (HP:0000679)1.40587014
180Sparse eyelashes (HP:0000653)1.40570704
181Amelogenesis imperfecta (HP:0000705)1.40447642
182Conjunctival hamartoma (HP:0100780)1.39460962
183Sclerocornea (HP:0000647)1.37547620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.41895548
2PASK5.11424107
3INSRR4.52776802
4EEF2K4.21725669
5ERN13.59671911
6MAPKAPK33.25667458
7WNK42.91011181
8SMG12.77497701
9MST1R2.45634250
10HIPK22.43585440
11MST42.32939278
12MAP3K22.30840402
13MAP2K22.26819305
14FLT32.02421590
15MAP3K11.91064175
16MET1.87306332
17EPHB11.84635319
18TLK11.82439552
19STK161.79757195
20RIPK11.78633654
21NTRK11.75513501
22BCKDK1.74717130
23PTK21.71491176
24MAP3K121.66888368
25MAP3K61.61774785
26SIK11.60175648
27WNK31.60052331
28EPHB21.59806442
29ABL21.59136904
30FRK1.55447557
31PTK61.45832329
32MAP3K31.45693227
33DYRK1B1.41088711
34FER1.34382725
35PIK3CG1.32799186
36ILK1.31560910
37FGFR31.29956774
38BMPR1B1.28227079
39MAPK121.27984389
40SGK2231.27521080
41SGK4941.27521080
42MARK11.17962439
43MARK21.16845661
44PIM21.12991127
45SGK21.09870869
46STK381.08823241
47MAPK131.08473104
48TRIB31.02010909
49PAK30.97979059
50TGFBR10.96821623
51MINK10.95247411
52RPS6KB20.95209510
53BRAF0.93979742
54LRRK20.91459732
55LATS10.90737140
56EPHA30.89864497
57ERBB30.89378183
58MAP2K10.87764670
59FGFR40.86242530
60MAP2K40.85127807
61PRKCI0.84821682
62EPHA20.80517642
63MYLK0.80494783
64TAOK30.80491745
65PDGFRA0.79982524
66ARAF0.78496280
67NME10.78118162
68MAP3K110.77321348
69PDPK10.75267788
70BMPR20.73815925
71ERBB20.71881187
72RPS6KA20.71588511
73IRAK10.70966659
74SGK30.64463492
75ZAP700.63265722
76GSK3A0.61702870
77FGFR10.60945578
78CDC42BPA0.60401538
79WNK10.59188158
80PKN10.58725708
81NEK60.57878765
82CHUK0.57132087
83PRKD10.57129353
84MAPKAPK20.56905143
85PRKAA20.56540430
86ITK0.54560172
87RPS6KB10.54168029
88OXSR10.52764720
89MAP2K60.52349127
90TBK10.51848018
91LMTK20.50903400
92UHMK10.50680713
93RPS6KC10.50219191
94RPS6KL10.50219191
95MAP3K130.49593357
96MAP3K140.49191620
97BRSK20.49144622
98CDK30.48017264
99SGK10.47924572
100PRKCE0.46955782
101CSK0.46928083
102PHKG10.45076627
103PHKG20.45076627
104GRK10.44821488
105JAK20.44488537
106TTK0.43531106
107PRKD20.41450669
108TESK10.41432552
109MAP2K30.41081498
110CDK90.40856194
111NLK0.40703782
112VRK10.39993418
113IGF1R0.39751140
114ZAK0.39707661
115PRKCD0.39195304
116PRKCQ0.38969301
117STK38L0.38896001
118AKT20.38741575
119TYK20.35493021
120PRKCZ0.34492995
121MTOR0.32474952
122MAPK90.32435281
123PRKACG0.31762510
124RPS6KA60.31660120
125DYRK20.31620725
126PRKACA0.31236285
127TRPM70.30919909
128MAPK30.30868647
129ALK0.30756327
130PTK2B0.30605019
131ROCK20.29131633
132CDK120.28167488
133STK100.27336043
134STK390.26748405
135ADRBK10.26157557
136BTK0.25711986
137MAPK110.25539563
138BLK0.24443305
139MAPKAPK50.23626593
140PAK20.23454178
141CSNK1A10.22226465
142STK240.21781345
143TAOK10.21238237
144RET0.21198818
145PRKD30.21189643
146MAPK80.20532697
147IKBKE0.20215560
148PRKCA0.20061964
149MAPK10.19779388
150MATK0.19704418
151CAMK2G0.19233971
152AKT10.18559688
153NEK20.18236421
154BMX0.17927567
155CHEK20.17338841
156BCR0.16852188
157PDGFRB0.16558913
158PRKCH0.15927245
159CDK60.15064459
160LATS20.13152041

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.81174653
2Protein export_Homo sapiens_hsa030604.08663227
3Sulfur metabolism_Homo sapiens_hsa009203.55791851
4Insulin secretion_Homo sapiens_hsa049112.40224236
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24183716
6Fatty acid biosynthesis_Homo sapiens_hsa000612.14785741
7Vibrio cholerae infection_Homo sapiens_hsa051101.95415918
8Folate biosynthesis_Homo sapiens_hsa007901.92489982
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.87414302
10Huntingtons disease_Homo sapiens_hsa050161.86743704
11Nitrogen metabolism_Homo sapiens_hsa009101.72604927
12Histidine metabolism_Homo sapiens_hsa003401.69125697
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67502026
14Pancreatic secretion_Homo sapiens_hsa049721.60877202
15Phototransduction_Homo sapiens_hsa047441.54491410
16Phenylalanine metabolism_Homo sapiens_hsa003601.54482827
17Type II diabetes mellitus_Homo sapiens_hsa049301.44287521
18N-Glycan biosynthesis_Homo sapiens_hsa005101.43966976
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43744999
20Protein digestion and absorption_Homo sapiens_hsa049741.42713282
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40684792
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.37635406
23Tight junction_Homo sapiens_hsa045301.36418979
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34978542
25Tryptophan metabolism_Homo sapiens_hsa003801.31806649
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31258496
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29476336
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28122110
29Sphingolipid metabolism_Homo sapiens_hsa006001.25915364
30Caffeine metabolism_Homo sapiens_hsa002321.23822161
31Selenocompound metabolism_Homo sapiens_hsa004501.23065306
32Glutathione metabolism_Homo sapiens_hsa004801.18077656
33Hepatitis C_Homo sapiens_hsa051601.15948374
34Linoleic acid metabolism_Homo sapiens_hsa005911.13696915
35Notch signaling pathway_Homo sapiens_hsa043301.11038528
36Other glycan degradation_Homo sapiens_hsa005111.08314381
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07304318
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07267705
39Lysosome_Homo sapiens_hsa041421.06116354
40Butanoate metabolism_Homo sapiens_hsa006501.05763112
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05595573
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04457656
43Tyrosine metabolism_Homo sapiens_hsa003501.03881761
44Starch and sucrose metabolism_Homo sapiens_hsa005001.02508356
45Fatty acid elongation_Homo sapiens_hsa000621.01618127
46Cocaine addiction_Homo sapiens_hsa050301.01155740
47Ribosome_Homo sapiens_hsa030101.00887926
48Nicotine addiction_Homo sapiens_hsa050330.97280392
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96867960
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.94118768
51Fat digestion and absorption_Homo sapiens_hsa049750.92562193
52Taste transduction_Homo sapiens_hsa047420.91970385
53Fatty acid degradation_Homo sapiens_hsa000710.91557238
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.91122705
55ABC transporters_Homo sapiens_hsa020100.90230371
56Thyroid hormone synthesis_Homo sapiens_hsa049180.89722750
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89240970
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87956859
59Galactose metabolism_Homo sapiens_hsa000520.87780094
60Retinol metabolism_Homo sapiens_hsa008300.85416607
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85038614
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83062241
63Choline metabolism in cancer_Homo sapiens_hsa052310.81943360
64Glycerolipid metabolism_Homo sapiens_hsa005610.80909076
65Regulation of autophagy_Homo sapiens_hsa041400.77398266
66Chemical carcinogenesis_Homo sapiens_hsa052040.76479273
67Vitamin digestion and absorption_Homo sapiens_hsa049770.75651267
68Hedgehog signaling pathway_Homo sapiens_hsa043400.74925178
69Insulin resistance_Homo sapiens_hsa049310.74242177
70Arachidonic acid metabolism_Homo sapiens_hsa005900.73915141
71Steroid biosynthesis_Homo sapiens_hsa001000.73466970
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.72196907
73Olfactory transduction_Homo sapiens_hsa047400.70676536
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.69802696
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69655678
76Pyruvate metabolism_Homo sapiens_hsa006200.69334073
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68948447
78Cardiac muscle contraction_Homo sapiens_hsa042600.67971394
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66197384
80Bladder cancer_Homo sapiens_hsa052190.64272217
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63640131
82Basal cell carcinoma_Homo sapiens_hsa052170.62192901
83Circadian rhythm_Homo sapiens_hsa047100.60545021
84Lysine degradation_Homo sapiens_hsa003100.59495539
85ECM-receptor interaction_Homo sapiens_hsa045120.59483412
86VEGF signaling pathway_Homo sapiens_hsa043700.58787294
87Renin-angiotensin system_Homo sapiens_hsa046140.58438429
88Fatty acid metabolism_Homo sapiens_hsa012120.57314143
89Glutamatergic synapse_Homo sapiens_hsa047240.56469456
90Ether lipid metabolism_Homo sapiens_hsa005650.56230527
91Ovarian steroidogenesis_Homo sapiens_hsa049130.56213051
92Prolactin signaling pathway_Homo sapiens_hsa049170.55383358
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54350613
94Salivary secretion_Homo sapiens_hsa049700.53806913
95Synaptic vesicle cycle_Homo sapiens_hsa047210.53687886
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53522216
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53401033
98Calcium signaling pathway_Homo sapiens_hsa040200.52073141
99Oxytocin signaling pathway_Homo sapiens_hsa049210.51348979
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51222927
101Glucagon signaling pathway_Homo sapiens_hsa049220.50933750
102Melanogenesis_Homo sapiens_hsa049160.50539829
103Type I diabetes mellitus_Homo sapiens_hsa049400.49756975
104Estrogen signaling pathway_Homo sapiens_hsa049150.49052356
105Renin secretion_Homo sapiens_hsa049240.48802188
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48659524
107Oxidative phosphorylation_Homo sapiens_hsa001900.47996156
108Collecting duct acid secretion_Homo sapiens_hsa049660.47166309
109Inositol phosphate metabolism_Homo sapiens_hsa005620.46541278
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.46108772
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46075174
112Peroxisome_Homo sapiens_hsa041460.45482765
113Morphine addiction_Homo sapiens_hsa050320.45046759
114Amphetamine addiction_Homo sapiens_hsa050310.44755070
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.42793016
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41076885
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40996692
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39780268
119Bile secretion_Homo sapiens_hsa049760.39436365
120beta-Alanine metabolism_Homo sapiens_hsa004100.38953621
121Amoebiasis_Homo sapiens_hsa051460.38867728
122Serotonergic synapse_Homo sapiens_hsa047260.37588285
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37226585
124Prion diseases_Homo sapiens_hsa050200.35383271
125mRNA surveillance pathway_Homo sapiens_hsa030150.34575244
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33093781
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31187692
128MAPK signaling pathway_Homo sapiens_hsa040100.30362729
129Axon guidance_Homo sapiens_hsa043600.30076991
130Complement and coagulation cascades_Homo sapiens_hsa046100.29720376
131Dorso-ventral axis formation_Homo sapiens_hsa043200.29582806
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29167932
133Ras signaling pathway_Homo sapiens_hsa040140.27265962
134Hippo signaling pathway_Homo sapiens_hsa043900.26541543
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26469039
136Thyroid cancer_Homo sapiens_hsa052160.26233131
137Arginine and proline metabolism_Homo sapiens_hsa003300.25255568
138Mineral absorption_Homo sapiens_hsa049780.24960555
139Vitamin B6 metabolism_Homo sapiens_hsa007500.24917624
140Metabolic pathways_Homo sapiens_hsa011000.24875012
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24399562
142GABAergic synapse_Homo sapiens_hsa047270.23580951
143Dopaminergic synapse_Homo sapiens_hsa047280.23422928
144GnRH signaling pathway_Homo sapiens_hsa049120.20904681
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.20831070
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19829657
147Gastric acid secretion_Homo sapiens_hsa049710.19786298
148Dilated cardiomyopathy_Homo sapiens_hsa054140.19184719
149Propanoate metabolism_Homo sapiens_hsa006400.19159448
150Circadian entrainment_Homo sapiens_hsa047130.18976480
151Cholinergic synapse_Homo sapiens_hsa047250.18342182

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