HS6ST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66862966
2synaptic vesicle maturation (GO:0016188)4.39328069
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27530223
4vocalization behavior (GO:0071625)4.07809853
5layer formation in cerebral cortex (GO:0021819)3.99464891
6locomotory exploration behavior (GO:0035641)3.99437656
7proline transport (GO:0015824)3.96642945
8chondrocyte proliferation (GO:0035988)3.92216035
9sequestering of extracellular ligand from receptor (GO:0035581)3.90381926
10neuron recognition (GO:0008038)3.83452799
11axonal fasciculation (GO:0007413)3.83125557
12synaptic vesicle exocytosis (GO:0016079)3.79198512
13glutamate secretion (GO:0014047)3.69783755
14exploration behavior (GO:0035640)3.67642726
15regulation of synaptic vesicle exocytosis (GO:2000300)3.67305192
16metanephric mesenchyme development (GO:0072075)3.59771701
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57807400
18neuron cell-cell adhesion (GO:0007158)3.50264360
19dendritic spine morphogenesis (GO:0060997)3.49976098
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49682633
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.48198232
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45567800
23protein localization to synapse (GO:0035418)3.41975666
24presynaptic membrane assembly (GO:0097105)3.38589739
25positive regulation of fibroblast migration (GO:0010763)3.36921418
26neurotransmitter secretion (GO:0007269)3.36597859
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.33977720
28kidney mesenchyme development (GO:0072074)3.32197989
29regulation of glutamate receptor signaling pathway (GO:1900449)3.31486693
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30138729
31DNA damage response, detection of DNA damage (GO:0042769)3.21700737
32dendrite morphogenesis (GO:0048813)3.19396828
33regulation of neuronal synaptic plasticity (GO:0048168)3.16878424
34cholesterol biosynthetic process (GO:0006695)3.15543255
35regulation of synapse structural plasticity (GO:0051823)3.13117656
36regulation of synaptic vesicle transport (GO:1902803)3.09034512
37glutamate receptor signaling pathway (GO:0007215)3.07409088
38pyrimidine nucleobase catabolic process (GO:0006208)3.05062231
39vesicle transport along microtubule (GO:0047496)3.02497913
40axon extension (GO:0048675)3.01386796
41cellular potassium ion homeostasis (GO:0030007)2.97424044
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97360302
43activation of protein kinase A activity (GO:0034199)2.95545931
44chromatin remodeling at centromere (GO:0031055)2.95488520
45plasma membrane repair (GO:0001778)2.94434660
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93901278
47innervation (GO:0060384)2.93440137
48regulation of dendritic spine morphogenesis (GO:0061001)2.92367908
49L-serine metabolic process (GO:0006563)2.91857378
50transmission of nerve impulse (GO:0019226)2.89172383
51nonmotile primary cilium assembly (GO:0035058)2.88377620
52establishment of nucleus localization (GO:0040023)2.87572092
53cell migration in hindbrain (GO:0021535)2.87461786
54olfactory bulb development (GO:0021772)2.85233266
55establishment of integrated proviral latency (GO:0075713)2.83089854
56DNA double-strand break processing (GO:0000729)2.82617295
57DNA strand elongation involved in DNA replication (GO:0006271)2.82515269
58sterol biosynthetic process (GO:0016126)2.80447135
59DNA unwinding involved in DNA replication (GO:0006268)2.80385260
60presynaptic membrane organization (GO:0097090)2.80072287
61neuron-neuron synaptic transmission (GO:0007270)2.79916744
62synaptic transmission, glutamatergic (GO:0035249)2.79620679
63collagen fibril organization (GO:0030199)2.78795673
64CENP-A containing nucleosome assembly (GO:0034080)2.78784661
65positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77267175
66organelle transport along microtubule (GO:0072384)2.74849292
67regulation of development, heterochronic (GO:0040034)2.74715140
68mating behavior (GO:0007617)2.74572068
69neurotransmitter transport (GO:0006836)2.73809740
70cerebellar Purkinje cell layer development (GO:0021680)2.72695188
71postsynaptic membrane organization (GO:0001941)2.72506134
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72214845
73intraciliary transport (GO:0042073)2.72159444
74positive regulation of synapse maturation (GO:0090129)2.71924130
75dopamine receptor signaling pathway (GO:0007212)2.70740811
76synaptic vesicle endocytosis (GO:0048488)2.70701244
77neuromuscular process controlling balance (GO:0050885)2.69405722
78DNA strand elongation (GO:0022616)2.69058359
79positive regulation of axon extension (GO:0045773)2.69054911
80behavioral defense response (GO:0002209)2.68749176
81behavioral fear response (GO:0001662)2.68749176
82regulation of vesicle fusion (GO:0031338)2.67540137
83isoprenoid biosynthetic process (GO:0008299)2.66836059
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66025101
85kinetochore organization (GO:0051383)2.65137431
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64797581
87regulation of glutamate secretion (GO:0014048)2.64591799
88neuron projection extension (GO:1990138)2.64413131
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63750075
90synapse organization (GO:0050808)2.63727444
91regulation of synaptic transmission, GABAergic (GO:0032228)2.61573853
92urinary tract smooth muscle contraction (GO:0014848)2.60840677
93axon extension involved in axon guidance (GO:0048846)2.59284151
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.59284151
95regulation of mitochondrial translation (GO:0070129)2.59108441
96positive regulation of vesicle fusion (GO:0031340)2.58413377
97dendritic spine organization (GO:0097061)2.58335720
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57597867
99gamma-aminobutyric acid signaling pathway (GO:0007214)2.56865077
100synapse assembly (GO:0007416)2.56595047
101positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56436138
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.55975971
103neuronal action potential propagation (GO:0019227)2.55743832
104positive regulation of synapse assembly (GO:0051965)2.54767272
105regulation of axon extension involved in axon guidance (GO:0048841)2.54510745
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53959126
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53559868
108regulation of postsynaptic membrane potential (GO:0060078)2.52437211
109prepulse inhibition (GO:0060134)2.50973317
110regulation of neurotransmitter levels (GO:0001505)2.49974804
111negative regulation of dendrite morphogenesis (GO:0050774)2.49828768
112regulation of cAMP-dependent protein kinase activity (GO:2000479)2.49385570
113cerebral cortex radially oriented cell migration (GO:0021799)2.49271347
114regulation of synaptic plasticity (GO:0048167)2.48799947
115neuromuscular synaptic transmission (GO:0007274)2.48362768
116regulation of timing of cell differentiation (GO:0048505)2.48009744
117protein heterotrimerization (GO:0070208)2.47180949
118gamma-aminobutyric acid transport (GO:0015812)2.46789749
119mitotic metaphase plate congression (GO:0007080)2.46211169
120nucleobase catabolic process (GO:0046113)2.45503987
121kinetochore assembly (GO:0051382)2.45132371
122telomere maintenance via semi-conservative replication (GO:0032201)2.44401932
123response to histamine (GO:0034776)2.43884861
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.43863922
125proximal/distal pattern formation (GO:0009954)2.43364203
126paraxial mesoderm development (GO:0048339)2.43320057
127negative regulation of oligodendrocyte differentiation (GO:0048715)2.42602327
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.42384500
129membrane depolarization during action potential (GO:0086010)2.42328239
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.41851553
131cell communication by electrical coupling (GO:0010644)2.41789693
132long-term memory (GO:0007616)2.41726089
133DNA ligation (GO:0006266)2.41364529
134DNA replication-independent nucleosome assembly (GO:0006336)2.40684981
135DNA replication-independent nucleosome organization (GO:0034724)2.40684981
136spliceosomal snRNP assembly (GO:0000387)2.40239595
137cullin deneddylation (GO:0010388)2.39806956
138mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39262757
139mitotic sister chromatid segregation (GO:0000070)2.37783063
140double-strand break repair via nonhomologous end joining (GO:0006303)2.34616060
141non-recombinational repair (GO:0000726)2.34616060
142sister chromatid segregation (GO:0000819)2.34076382
143forebrain neuron differentiation (GO:0021879)2.32477671
144protein localization to kinetochore (GO:0034501)2.32406043
145histone exchange (GO:0043486)2.30711795
146DNA replication checkpoint (GO:0000076)2.30406454
147DNA replication-dependent nucleosome assembly (GO:0006335)2.29880757
148DNA replication-dependent nucleosome organization (GO:0034723)2.29880757
149purine nucleobase biosynthetic process (GO:0009113)2.29731829
150mitotic recombination (GO:0006312)2.25784530
151metaphase plate congression (GO:0051310)2.23325722
152proteasome assembly (GO:0043248)2.22994977
153retinal ganglion cell axon guidance (GO:0031290)2.22279247
154heterochromatin organization (GO:0070828)2.20479868
155spindle checkpoint (GO:0031577)2.17993396
156histone H2A acetylation (GO:0043968)2.17850291
157notochord development (GO:0030903)2.17177903
158regulation of sister chromatid cohesion (GO:0007063)2.16768601
159negative regulation of glial cell differentiation (GO:0045686)2.15309742
160peptidyl-arginine omega-N-methylation (GO:0035247)2.15305739
161IMP biosynthetic process (GO:0006188)2.15074153
162cell proliferation in forebrain (GO:0021846)2.14010241
163auditory behavior (GO:0031223)2.11729761
164negative regulation of astrocyte differentiation (GO:0048712)2.11687334
165limb development (GO:0060173)2.11618134
166appendage development (GO:0048736)2.11618134
167telomere maintenance via recombination (GO:0000722)2.10634202
168negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.10540366
169protein localization to chromosome, centromeric region (GO:0071459)2.10411598
170mitotic spindle checkpoint (GO:0071174)2.10398728
171ATP-dependent chromatin remodeling (GO:0043044)2.10276184
172nuclear pore organization (GO:0006999)2.09533782
173generation of neurons (GO:0048699)2.09343615
174nucleobase biosynthetic process (GO:0046112)2.09061185
175termination of RNA polymerase II transcription (GO:0006369)2.08872066
176negative regulation of chromosome segregation (GO:0051985)2.08860540
177hippocampus development (GO:0021766)2.07958185
178establishment of mitochondrion localization (GO:0051654)2.07815182
179outer ear morphogenesis (GO:0042473)2.07235034
180negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.06578682
181negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.06578682
182negative regulation of mitotic sister chromatid segregation (GO:0033048)2.06578682
183negative regulation of mitotic sister chromatid separation (GO:2000816)2.06578682
184negative regulation of sister chromatid segregation (GO:0033046)2.06578682
185ubiquinone metabolic process (GO:0006743)2.05212599
186limb bud formation (GO:0060174)2.02964948
187anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.02941930
188IMP metabolic process (GO:0046040)2.02876362
189protein deneddylation (GO:0000338)2.02558693
190regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.02468865
191regulation of mitotic metaphase/anaphase transition (GO:0030071)2.02468865
192protein heterotetramerization (GO:0051290)2.02433796
193negative regulation of mRNA processing (GO:0050686)2.02190833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.60907828
2E2F7_22180533_ChIP-Seq_HELA_Human4.35857269
3GBX2_23144817_ChIP-Seq_PC3_Human3.29669453
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02423208
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94557529
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94475851
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91554013
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77573433
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77573433
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69035698
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66956399
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58999934
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56940572
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.56351736
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.53484836
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.53215168
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52931232
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30490447
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.29640453
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29353324
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.19389439
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.18641051
23AR_21909140_ChIP-Seq_LNCAP_Human2.17996367
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14363361
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13621852
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.13422938
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.08926910
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04871732
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04457442
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02083443
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.96960101
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96648034
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.93639137
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93361624
35ELK1_19687146_ChIP-ChIP_HELA_Human1.93142906
36ZNF274_21170338_ChIP-Seq_K562_Hela1.93120667
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91553649
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89444035
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85024310
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83677404
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82430234
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80639773
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79878515
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78366195
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77432987
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75610694
47REST_21632747_ChIP-Seq_MESCs_Mouse1.75333777
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73969677
49* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73546309
50TAF15_26573619_Chip-Seq_HEK293_Human1.71499870
51* RARB_27405468_Chip-Seq_BRAIN_Mouse1.71275722
52DROSHA_22980978_ChIP-Seq_HELA_Human1.70943300
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69270176
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69165692
55AR_21572438_ChIP-Seq_LNCaP_Human1.69045748
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.68319071
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65867669
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.63092090
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62704057
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62551252
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60506215
62JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60333226
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58185388
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.57631057
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54840833
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.52874500
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50171168
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.48793509
69P300_19829295_ChIP-Seq_ESCs_Human1.47587198
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.47570429
71XRN2_22483619_ChIP-Seq_HELA_Human1.47264148
72MYC_18940864_ChIP-ChIP_HL60_Human1.47153203
73* TP53_18474530_ChIP-ChIP_U2OS_Human1.47055328
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46253539
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45812776
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.45132103
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44544569
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43499509
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42644202
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.40769210
81* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40671970
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40491399
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.40063838
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39627032
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39348413
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37605222
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37542136
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.37049149
89* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36499509
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36193138
91* TP53_16413492_ChIP-PET_HCT116_Human1.36008882
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35190899
93IGF1R_20145208_ChIP-Seq_DFB_Human1.34393163
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.33057972
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32940706
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32658074
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31676007
98TTF2_22483619_ChIP-Seq_HELA_Human1.31308435
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30918775
100* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29857640
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29532321
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29452662
103FUS_26573619_Chip-Seq_HEK293_Human1.28767595
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28058182
105RNF2_27304074_Chip-Seq_NSC_Mouse1.27913416
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.27875420
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.27793548
108* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26739647
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.25976404
110GABP_19822575_ChIP-Seq_HepG2_Human1.24738517
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24497047
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.24269807
113AR_25329375_ChIP-Seq_VCAP_Human1.24037833
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23358137
115MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23206308
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22727409
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21206320
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21064836
119* TP53_20018659_ChIP-ChIP_R1E_Mouse1.20956374
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.20944718
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19073010
122* JUN_21703547_ChIP-Seq_K562_Human1.18456462
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18389207
124DCP1A_22483619_ChIP-Seq_HELA_Human1.17430483
125* AR_19668381_ChIP-Seq_PC3_Human1.16814211
126POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16347441
127AHR_22903824_ChIP-Seq_MCF-7_Human1.16169557
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.15489891
129STAT3_23295773_ChIP-Seq_U87_Human1.15307267
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15027907
131WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14050244
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13817476
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11706877
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11375620
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10052056
136NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10052056
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09043844
138SOX9_26525672_Chip-Seq_HEART_Mouse1.08860333
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08803660
140YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08172519
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07512043
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07343104
143VDR_23849224_ChIP-Seq_CD4+_Human1.05592502
144EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05553509
145ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05527713
146TP63_19390658_ChIP-ChIP_HaCaT_Human1.05392107
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02310486
148RUNX2_22187159_ChIP-Seq_PCA_Human0.99086077
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98511583
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.98044016
151EWS_26573619_Chip-Seq_HEK293_Human0.97864468
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.97672909
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97417008
154* BCAT_22108803_ChIP-Seq_LS180_Human0.96455196
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95908762
156CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95637234
157* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95457518
158FOXP3_21729870_ChIP-Seq_TREG_Human0.95200871
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94844515
160TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.94652281
161* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94118785
162TCF4_23295773_ChIP-Seq_U87_Human0.93974677
163SMAD3_21741376_ChIP-Seq_ESCs_Human0.93461627
164HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93021328
165* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92211479
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90190073
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.87104995
168GATA1_26923725_Chip-Seq_HPCs_Mouse0.85753675
169ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85235196
170POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85069771
171MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84714298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.15153696
2MP0008438_abnormal_cutaneous_collagen3.49460887
3MP0003880_abnormal_central_pattern3.28881413
4MP0000566_synostosis3.20709155
5MP0001968_abnormal_touch/_nociception2.89710943
6MP0006292_abnormal_olfactory_placode2.86968727
7MP0003635_abnormal_synaptic_transmissio2.84919246
8MP0003122_maternal_imprinting2.80779134
9MP0005248_abnormal_Harderian_gland2.63767271
10MP0004270_analgesia2.57401531
11MP0002736_abnormal_nociception_after2.54668069
12MP0003283_abnormal_digestive_organ2.49004937
13MP0008789_abnormal_olfactory_epithelium2.44580083
14MP0005623_abnormal_meninges_morphology2.43170341
15MP0005503_abnormal_tendon_morphology2.37119652
16MP0002063_abnormal_learning/memory/cond2.28879605
17MP0009745_abnormal_behavioral_response2.24816175
18MP0006276_abnormal_autonomic_nervous2.19351901
19MP0001293_anophthalmia2.14365976
20MP0005275_abnormal_skin_tensile2.12183951
21MP0005394_taste/olfaction_phenotype2.11151496
22MP0005499_abnormal_olfactory_system2.11151496
23MP0010094_abnormal_chromosome_stability2.04637787
24MP0002734_abnormal_mechanical_nocicepti2.00548156
25MP0005187_abnormal_penis_morphology1.98591962
26MP0002064_seizures1.94776109
27MP0002735_abnormal_chemical_nociception1.93182375
28MP0002572_abnormal_emotion/affect_behav1.90759573
29MP0009046_muscle_twitch1.88136611
30MP0002733_abnormal_thermal_nociception1.84468537
31MP0001501_abnormal_sleep_pattern1.79340992
32MP0003123_paternal_imprinting1.78703464
33MP0009780_abnormal_chondrocyte_physiolo1.76085825
34MP0002272_abnormal_nervous_system1.76060263
35MP0002697_abnormal_eye_size1.74976422
36MP0002938_white_spotting1.73915217
37MP0003937_abnormal_limbs/digits/tail_de1.73702224
38MP0002184_abnormal_innervation1.71825735
39MP0001299_abnormal_eye_distance/1.67507769
40MP0008058_abnormal_DNA_repair1.62221240
41MP0003705_abnormal_hypodermis_morpholog1.61845261
42MP0000778_abnormal_nervous_system1.60284347
43MP0008932_abnormal_embryonic_tissue1.60158428
44MP0003279_aneurysm1.57315040
45MP0004858_abnormal_nervous_system1.56799092
46MP0001440_abnormal_grooming_behavior1.54435857
47MP0004957_abnormal_blastocyst_morpholog1.54389675
48MP0001486_abnormal_startle_reflex1.53846771
49MP0003693_abnormal_embryo_hatching1.53084279
50MP0003385_abnormal_body_wall1.53064823
51MP0001970_abnormal_pain_threshold1.50490164
52MP0005423_abnormal_somatic_nervous1.50255936
53MP0001188_hyperpigmentation1.48800851
54MP0003119_abnormal_digestive_system1.48594184
55MP0001346_abnormal_lacrimal_gland1.48314816
56MP0003121_genomic_imprinting1.47574453
57MP0002102_abnormal_ear_morphology1.47253182
58MP0000579_abnormal_nail_morphology1.47120681
59MP0001958_emphysema1.46115708
60MP0009384_cardiac_valve_regurgitation1.42398403
61MP0002092_abnormal_eye_morphology1.41751083
62MP0000534_abnormal_ureter_morphology1.40284147
63MP0003111_abnormal_nucleus_morphology1.37153858
64MP0002067_abnormal_sensory_capabilities1.35971879
65MP0003942_abnormal_urinary_system1.35601527
66MP0000013_abnormal_adipose_tissue1.35578802
67MP0009250_abnormal_appendicular_skeleto1.35414198
68MP0002249_abnormal_larynx_morphology1.34004665
69MP0000751_myopathy1.31012599
70MP0002557_abnormal_social/conspecific_i1.30502322
71MP0001286_abnormal_eye_development1.29901907
72MP0003077_abnormal_cell_cycle1.29587357
73MP0004811_abnormal_neuron_physiology1.27655462
74MP0003938_abnormal_ear_development1.27050131
75MP0001348_abnormal_lacrimal_gland1.24325660
76MP0004272_abnormal_basement_membrane1.23082667
77MP0004145_abnormal_muscle_electrophysio1.22931834
78MP0000647_abnormal_sebaceous_gland1.22887670
79MP0004133_heterotaxia1.22719306
80MP0003315_abnormal_perineum_morphology1.18347104
81MP0005391_vision/eye_phenotype1.18197666
82MP0000955_abnormal_spinal_cord1.16044719
83MP0004233_abnormal_muscle_weight1.15258425
84MP0006072_abnormal_retinal_apoptosis1.15254692
85MP0005386_behavior/neurological_phenoty1.14250418
86MP0004924_abnormal_behavior1.14250418
87MP0001177_atelectasis1.11932336
88MP0004197_abnormal_fetal_growth/weight/1.11821365
89MP0003890_abnormal_embryonic-extraembry1.08202918
90MP0000569_abnormal_digit_pigmentation1.08007599
91MP0003787_abnormal_imprinting1.07722040
92MP0000537_abnormal_urethra_morphology1.07331616
93MP0003329_amyloid_beta_deposits1.07115893
94MP0003879_abnormal_hair_cell1.04866456
95MP0002882_abnormal_neuron_morphology1.04735291
96MP0008877_abnormal_DNA_methylation1.03767242
97MP0002822_catalepsy1.02840159
98MP0005253_abnormal_eye_physiology1.02785050
99MP0003091_abnormal_cell_migration1.02142297
100MP0010030_abnormal_orbit_morphology1.02035467
101MP0005645_abnormal_hypothalamus_physiol1.00550895
102MP0002084_abnormal_developmental_patter0.99295537
103MP0005508_abnormal_skeleton_morphology0.99015356
104MP0002111_abnormal_tail_morphology0.95670831
105MP0002085_abnormal_embryonic_tissue0.95170826
106MP0002752_abnormal_somatic_nervous0.95085533
107MP0002090_abnormal_vision0.94698587
108MP0002108_abnormal_muscle_morphology0.94689039
109MP0004134_abnormal_chest_morphology0.94276798
110MP0010352_gastrointestinal_tract_polyps0.93965458
111MP0002066_abnormal_motor_capabilities/c0.93432162
112MP0003136_yellow_coat_color0.93339832
113MP0003755_abnormal_palate_morphology0.92329014
114MP0008057_abnormal_DNA_replication0.92319680
115MP0002295_abnormal_pulmonary_circulatio0.91993818
116MP0002098_abnormal_vibrissa_morphology0.91510099
117MP0008569_lethality_at_weaning0.91163275
118MP0003935_abnormal_craniofacial_develop0.90115530
119MP0000462_abnormal_digestive_system0.90108818
120MP0009379_abnormal_foot_pigmentation0.88644996
121MP0002152_abnormal_brain_morphology0.88500665
122MP0009697_abnormal_copulation0.88489430
123MP0009053_abnormal_anal_canal0.88415152
124MP0003115_abnormal_respiratory_system0.88258937
125MP0002282_abnormal_trachea_morphology0.87237241
126MP0000026_abnormal_inner_ear0.86571481
127MP0010234_abnormal_vibrissa_follicle0.85409242
128MP0000762_abnormal_tongue_morphology0.83949289
129MP0002909_abnormal_adrenal_gland0.83396216
130MP0002081_perinatal_lethality0.82725631
131MP0005195_abnormal_posterior_eye0.81218154
132MP0001984_abnormal_olfaction0.80928822
133MP0005171_absent_coat_pigmentation0.80184637
134MP0002751_abnormal_autonomic_nervous0.80101770
135MP0002896_abnormal_bone_mineralization0.78742379
136MP0001340_abnormal_eyelid_morphology0.77905551
137MP0009672_abnormal_birth_weight0.77303181
138MP0002233_abnormal_nose_morphology0.76659351
139MP0003861_abnormal_nervous_system0.74860134
140MP0001905_abnormal_dopamine_level0.73221629
141MP0001529_abnormal_vocalization0.72884754
142MP0002234_abnormal_pharynx_morphology0.72602198
143MP0001943_abnormal_respiration0.72559463
144MP0004085_abnormal_heartbeat0.72453921
145MP0000428_abnormal_craniofacial_morphol0.72280299
146MP0002932_abnormal_joint_morphology0.71108880
147MP0000049_abnormal_middle_ear0.70956049
148MP0000631_abnormal_neuroendocrine_gland0.70637522
149MP0002837_dystrophic_cardiac_calcinosis0.70587939
150MP0002116_abnormal_craniofacial_bone0.68483513
151MP0004484_altered_response_of0.68105544
152MP0004142_abnormal_muscle_tone0.65670321
153MP0000516_abnormal_urinary_system0.65657726
154MP0005367_renal/urinary_system_phenotyp0.65657726

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.74860398
2Premature rupture of membranes (HP:0001788)4.39229817
3Focal motor seizures (HP:0011153)3.74748560
4Myokymia (HP:0002411)3.60940394
5Focal seizures (HP:0007359)3.54937117
6Hepatoblastoma (HP:0002884)3.46023761
7Abnormality of dentin (HP:0010299)3.29256107
8Colon cancer (HP:0003003)3.25215392
9Shallow orbits (HP:0000586)3.18520748
10Atonic seizures (HP:0010819)2.83787972
11Visual hallucinations (HP:0002367)2.77672455
12Buphthalmos (HP:0000557)2.70656779
13Abnormality of the labia minora (HP:0012880)2.66979847
14Dilatation of the ascending aorta (HP:0005111)2.65599726
15Bladder diverticulum (HP:0000015)2.62767467
16Medulloblastoma (HP:0002885)2.56895263
17Aortic dissection (HP:0002647)2.56882412
18High anterior hairline (HP:0009890)2.56212505
19Absence seizures (HP:0002121)2.51922981
20Bowel diverticulosis (HP:0005222)2.49882594
21Genu recurvatum (HP:0002816)2.49022930
22Atrophic scars (HP:0001075)2.45214063
23Hypoventilation (HP:0002791)2.42440903
24Overgrowth (HP:0001548)2.41057577
25Glioma (HP:0009733)2.39989726
26Action tremor (HP:0002345)2.36808668
27Epileptic encephalopathy (HP:0200134)2.31437156
28Progressive cerebellar ataxia (HP:0002073)2.30764094
29Hyperglycinemia (HP:0002154)2.30617307
30Follicular hyperkeratosis (HP:0007502)2.28348825
31Cortical dysplasia (HP:0002539)2.28194421
32Vascular tortuosity (HP:0004948)2.25996390
33Cerebral aneurysm (HP:0004944)2.25950002
34Abnormality of the astrocytes (HP:0100707)2.25908541
35Astrocytoma (HP:0009592)2.25908541
36Generalized tonic-clonic seizures (HP:0002069)2.25852387
37Termporal pattern (HP:0011008)2.25078369
38Insidious onset (HP:0003587)2.25078369
39Papilledema (HP:0001085)2.24666322
40Oligodactyly (HP:0012165)2.24406073
41Ankle contracture (HP:0006466)2.24365900
42Soft skin (HP:0000977)2.23933961
43Peritonitis (HP:0002586)2.22770380
44Gait imbalance (HP:0002141)2.22096608
45Fragile skin (HP:0001030)2.21531985
46Increased serum pyruvate (HP:0003542)2.19695726
47Mitral valve prolapse (HP:0001634)2.18568274
48Neonatal short-limb short stature (HP:0008921)2.18370794
49Broad metatarsal (HP:0001783)2.17115522
50Febrile seizures (HP:0002373)2.16522774
51Dialeptic seizures (HP:0011146)2.12997051
52Lower limb amyotrophy (HP:0007210)2.12354262
53Aortic aneurysm (HP:0004942)2.10601567
54Abnormal lung lobation (HP:0002101)2.10059192
55Congenital primary aphakia (HP:0007707)2.08982175
56Wrist flexion contracture (HP:0001239)2.06992850
57Ankle clonus (HP:0011448)2.06733695
58Abnormality of glycolysis (HP:0004366)2.06612469
59Infantile muscular hypotonia (HP:0008947)2.03294048
60Renal hypoplasia (HP:0000089)2.00119529
61Arterial tortuosity (HP:0005116)1.96762240
62Wormian bones (HP:0002645)1.96684030
63Limb dystonia (HP:0002451)1.95906196
64Microglossia (HP:0000171)1.95562177
65Torticollis (HP:0000473)1.94708022
66Vaginal atresia (HP:0000148)1.94314170
67Shoulder girdle muscle weakness (HP:0003547)1.93443626
68Hyperextensible skin (HP:0000974)1.93123501
69Preaxial hand polydactyly (HP:0001177)1.92655488
70Ankyloglossia (HP:0010296)1.92440399
71Renal dysplasia (HP:0000110)1.92372607
72Medial flaring of the eyebrow (HP:0010747)1.92319163
73Anophthalmia (HP:0000528)1.92188558
74Esophageal atresia (HP:0002032)1.91975488
75Congenital glaucoma (HP:0001087)1.90905168
76Narrow nasal bridge (HP:0000446)1.88679341
77Genital tract atresia (HP:0001827)1.88290862
78Morphological abnormality of the middle ear (HP:0008609)1.88290560
79Nephrogenic diabetes insipidus (HP:0009806)1.88184673
80Postaxial foot polydactyly (HP:0001830)1.88178515
81Urinary urgency (HP:0000012)1.87261263
82Abnormality of the metopic suture (HP:0005556)1.86704016
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.86617112
84Ectopic kidney (HP:0000086)1.86372751
85Rib fusion (HP:0000902)1.85644526
86Abnormality of oral frenula (HP:0000190)1.84342043
87Sclerocornea (HP:0000647)1.83922325
88Volvulus (HP:0002580)1.82514339
89Postaxial hand polydactyly (HP:0001162)1.81396378
90Amblyopia (HP:0000646)1.80087032
91Increased variability in muscle fiber diameter (HP:0003557)1.80038617
92Impaired vibration sensation in the lower limbs (HP:0002166)1.79046878
93Depression (HP:0000716)1.78764752
94Abnormality of the diencephalon (HP:0010662)1.78726682
95Spinal cord compression (HP:0002176)1.78720316
96Asymmetry of the thorax (HP:0001555)1.78645221
97Papillary thyroid carcinoma (HP:0002895)1.78562322
98Septo-optic dysplasia (HP:0100842)1.78206773
99Excessive salivation (HP:0003781)1.77819128
100Drooling (HP:0002307)1.77819128
101Bronchomalacia (HP:0002780)1.77741185
102Broad-based gait (HP:0002136)1.77346072
103Cervical subluxation (HP:0003308)1.77310404
104Delayed gross motor development (HP:0002194)1.77286359
105Dysdiadochokinesis (HP:0002075)1.76287602
106Mild short stature (HP:0003502)1.75496812
107Truncal ataxia (HP:0002078)1.75446537
108Deviation of the hallux (HP:0010051)1.75104042
109Agitation (HP:0000713)1.75014088
110Postnatal microcephaly (HP:0005484)1.75006058
111Testicular neoplasm (HP:0010788)1.74827904
112Split foot (HP:0001839)1.72303835
113Optic nerve hypoplasia (HP:0000609)1.71903453
114Vitreoretinal degeneration (HP:0000655)1.71602449
115Hemivertebrae (HP:0002937)1.71394344
116Failure to thrive in infancy (HP:0001531)1.71001007
117True hermaphroditism (HP:0010459)1.70855091
118Pointed chin (HP:0000307)1.70588568
119Urinary bladder sphincter dysfunction (HP:0002839)1.70560171
120Aqueductal stenosis (HP:0002410)1.70384314
121Hallux valgus (HP:0001822)1.69667383
122Trigonocephaly (HP:0000243)1.69112534
123Megalencephaly (HP:0001355)1.68307526
124Pancreatic fibrosis (HP:0100732)1.68163450
125Spinal rigidity (HP:0003306)1.67111076
126Abnormality of pain sensation (HP:0010832)1.66811618
127Impaired pain sensation (HP:0007328)1.66811618
128Cutaneous finger syndactyly (HP:0010554)1.66651659
129Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66448124
130Short 4th metacarpal (HP:0010044)1.66448124
131Morphological abnormality of the inner ear (HP:0011390)1.66420863
132Facial hemangioma (HP:0000329)1.65969957
133Bicornuate uterus (HP:0000813)1.65808242
134Aplasia involving bones of the extremities (HP:0009825)1.65793153
135Aplasia involving bones of the upper limbs (HP:0009823)1.65793153
136Aplasia of the phalanges of the hand (HP:0009802)1.65793153
137Gastrointestinal atresia (HP:0002589)1.65523899
138Increased nuchal translucency (HP:0010880)1.65365904
139Pterygium (HP:0001059)1.65208920
140Occipital encephalocele (HP:0002085)1.65114099
141Abnormality of the corticospinal tract (HP:0002492)1.64532273
142Bifid tongue (HP:0010297)1.64360587
143Anxiety (HP:0000739)1.64330069
144Oligodactyly (hands) (HP:0001180)1.64288171
145Preaxial foot polydactyly (HP:0001841)1.64041454
146Macroorchidism (HP:0000053)1.63419819
147Coronal craniosynostosis (HP:0004440)1.63374841
148Broad ribs (HP:0000885)1.62105025
149Abnormality of the antihelix (HP:0009738)1.62082748
150Type 1 muscle fiber predominance (HP:0003803)1.62033143
151Nephronophthisis (HP:0000090)1.61428005
152Exercise-induced muscle cramps (HP:0003710)1.61127618
153Poor coordination (HP:0002370)1.59574538
154Striae distensae (HP:0001065)1.58805853
155Poor suck (HP:0002033)1.58786541
156Pheochromocytoma (HP:0002666)1.58505373
157Retinal dysplasia (HP:0007973)1.58169387
158Type 2 muscle fiber atrophy (HP:0003554)1.58066908
159Obstructive sleep apnea (HP:0002870)1.57864821
160Supranuclear gaze palsy (HP:0000605)1.57749586
161Mitral regurgitation (HP:0001653)1.57551630
162Hypoplastic pelvis (HP:0008839)1.57483331
163Biconcave vertebral bodies (HP:0004586)1.57366394
164Neoplasm of the adrenal cortex (HP:0100641)1.57348083
165Facial cleft (HP:0002006)1.56816584
166Dyskinesia (HP:0100660)1.56628040
167Cutaneous syndactyly (HP:0012725)1.56509702
168Broad foot (HP:0001769)1.55926967
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.55758392
170Intestinal atresia (HP:0011100)1.54861759
171Abnormality of the phalanges of the hallux (HP:0010057)1.54103964
172Median cleft lip (HP:0000161)1.53777881
173Absent septum pellucidum (HP:0001331)1.53423950
174Chorioretinal coloboma (HP:0000567)1.53254127
175Decreased testicular size (HP:0008734)1.53059665
176Abnormality of the 4th metacarpal (HP:0010012)1.52141586
177Acute necrotizing encephalopathy (HP:0006965)1.51602055
178Triphalangeal thumb (HP:0001199)1.51330534
179Amniotic constriction ring (HP:0009775)1.50665581
180Abnormality of placental membranes (HP:0011409)1.50665581
181Spastic diplegia (HP:0001264)1.49021466
182Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.48843870
183Short tibia (HP:0005736)1.48455042
184Supernumerary spleens (HP:0009799)1.48265913
185Specific learning disability (HP:0001328)1.48157564
186Acute encephalopathy (HP:0006846)1.47865484
187Abnormality of midbrain morphology (HP:0002418)1.46848228
188Molar tooth sign on MRI (HP:0002419)1.46848228
189Proximal placement of thumb (HP:0009623)1.46654883
190Vertebral clefting (HP:0008428)1.46299020
191Abnormal mitochondria in muscle tissue (HP:0008316)1.45891073
192Abnormality of glycine metabolism (HP:0010895)1.45134624
193Abnormality of serine family amino acid metabolism (HP:0010894)1.45134624
194Meckel diverticulum (HP:0002245)1.44679233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.86380362
2MAP3K93.26823720
3MINK13.10022291
4EPHA43.08611591
5SRPK13.04436448
6MARK12.99574172
7LATS22.82269147
8DDR22.64316987
9MAP3K42.59035136
10CDC72.47634930
11CSNK1A1L2.34547232
12PLK22.30113689
13BUB12.18649181
14CSNK1G12.11598023
15NTRK12.09894166
16TRIM282.08651549
17PAK62.08383393
18TSSK62.07389473
19PAK32.05298575
20MKNK12.04982795
21LIMK11.93397812
22PRKD31.89729057
23MAP2K71.86370124
24WEE11.75467402
25KSR21.70231715
26PBK1.69119283
27MAP4K21.66222552
28FER1.65683842
29STK161.63393489
30PDGFRA1.62556488
31MAP2K41.58456936
32KSR11.55731542
33MAPK131.55687190
34NTRK21.51320748
35CASK1.45394944
36TTK1.45159006
37DYRK21.44317564
38PNCK1.42434061
39MAP3K121.41985032
40CAMKK11.36537080
41PTK2B1.34614223
42ERBB31.34597889
43MKNK21.28589159
44STK391.24583117
45CDK51.24065146
46PLK41.21646987
47TTN1.21478005
48GRK51.20617411
49RIPK41.20322240
50EIF2AK11.18871412
51CDK141.18751313
52RPS6KA41.17185587
53SCYL21.11715838
54CAMK2A1.10995548
55PLK11.07730591
56CCNB11.07316888
57DAPK21.06822511
58CDK181.04762970
59TYRO31.03431005
60BMPR1B1.02727697
61CDK151.02531938
62PRKCG1.02130759
63RET1.01108001
64NME11.00413987
65SIK20.99545344
66UHMK10.97619460
67DYRK30.96636089
68ATR0.95684887
69VRK20.94511221
70MAP3K20.92237687
71PRPF4B0.91951300
72BRSK10.91547725
73MET0.90829166
74CSNK1G20.90578659
75MST1R0.89048920
76TESK10.88493044
77MAP3K100.87979179
78CDK11A0.86333920
79EPHB20.86137448
80STK380.85172326
81LATS10.84194427
82VRK10.84029833
83CHEK20.84004033
84MOS0.83528511
85PRKCH0.82869333
86PTK20.79870821
87DMPK0.78869788
88PHKG10.78746271
89PHKG20.78746271
90ROCK10.78691331
91BRD40.78587270
92PAK20.77395693
93CAMKK20.77027582
94WNK40.76866237
95EPHA30.75843262
96MAP2K10.75550376
97ARAF0.74618447
98STK38L0.74044661
99RIPK10.71830198
100NEK90.71772922
101ALK0.71301864
102TNK20.70548681
103ROCK20.69446655
104AURKB0.68570294
105WNK10.67750478
106EPHA20.66751661
107CDC42BPA0.64604109
108BRSK20.64488229
109NUAK10.63173913
110WNK30.62864202
111TRIB30.62126270
112RPS6KA20.61946855
113ADRBK10.61528919
114ATM0.61527872
115PRKCE0.61316478
116CDK80.60823855
117NEK10.60507384
118PLK30.60053148
119PIK3CA0.58096016
120FGFR10.57922323
121FGFR20.56927968
122STK110.56419895
123TAOK10.56163691
124FRK0.56097846
125MAPK150.55182567
126CAMK2B0.54942630
127BCKDK0.54826661
128PRKCZ0.53842383
129CHEK10.53771922
130OBSCN0.53229463
131OXSR10.53036472
132CSNK1E0.51772524
133MST40.50172844
134SGK10.49966894
135CSNK1G30.49074711
136EIF2AK20.48002319
137CDK30.47782323
138SGK4940.47669276
139SGK2230.47669276
140ZAK0.47348635
141BRAF0.47157450
142PDGFRB0.47053573
143PAK40.46702044
144BMX0.46425130
145FES0.46412793
146LMTK20.46379321
147FYN0.46295479
148EIF2AK30.46103777
149MAPKAPK50.45392202
150CSNK1A10.44833897
151CSNK1D0.44432273
152AURKA0.44073221
153CAMK2D0.43962592
154MAPK100.43163692
155YES10.43048680
156SGK20.42686306
157CDK10.42267186
158BCR0.41160390
159RPS6KA30.40670579
160CAMK2G0.39480062
161TNIK0.39211323
162CAMK1G0.39062544

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.07914998
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.05542974
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95293356
4Steroid biosynthesis_Homo sapiens_hsa001002.93103036
5DNA replication_Homo sapiens_hsa030302.59175324
6Synaptic vesicle cycle_Homo sapiens_hsa047212.53007087
7Mismatch repair_Homo sapiens_hsa034302.43297482
8Long-term potentiation_Homo sapiens_hsa047202.26839388
9Protein export_Homo sapiens_hsa030602.22428176
10GABAergic synapse_Homo sapiens_hsa047272.18591528
11Amphetamine addiction_Homo sapiens_hsa050312.17252975
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10948532
13Circadian entrainment_Homo sapiens_hsa047132.10512027
14Non-homologous end-joining_Homo sapiens_hsa034502.08954816
15Proteasome_Homo sapiens_hsa030502.06680985
16Spliceosome_Homo sapiens_hsa030402.05200560
17Dopaminergic synapse_Homo sapiens_hsa047282.04596360
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03896663
19Olfactory transduction_Homo sapiens_hsa047401.99252771
20Glutamatergic synapse_Homo sapiens_hsa047241.97396421
21Homologous recombination_Homo sapiens_hsa034401.96351528
22Morphine addiction_Homo sapiens_hsa050321.93317967
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83644822
24Serotonergic synapse_Homo sapiens_hsa047261.83263927
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78676363
26Fanconi anemia pathway_Homo sapiens_hsa034601.77647124
27Base excision repair_Homo sapiens_hsa034101.75886207
28Cocaine addiction_Homo sapiens_hsa050301.71081510
29Salivary secretion_Homo sapiens_hsa049701.68138825
30RNA transport_Homo sapiens_hsa030131.66610020
31Long-term depression_Homo sapiens_hsa047301.64989832
32Axon guidance_Homo sapiens_hsa043601.63742450
33Cholinergic synapse_Homo sapiens_hsa047251.62691299
34Cell cycle_Homo sapiens_hsa041101.62686712
35Nucleotide excision repair_Homo sapiens_hsa034201.60452812
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59158137
37RNA polymerase_Homo sapiens_hsa030201.58506457
38Propanoate metabolism_Homo sapiens_hsa006401.57481152
39Taste transduction_Homo sapiens_hsa047421.57120336
40Gap junction_Homo sapiens_hsa045401.57030094
41GnRH signaling pathway_Homo sapiens_hsa049121.56626632
42Oxytocin signaling pathway_Homo sapiens_hsa049211.51395400
43Gastric acid secretion_Homo sapiens_hsa049711.50765627
44Renin secretion_Homo sapiens_hsa049241.48772428
45Oxidative phosphorylation_Homo sapiens_hsa001901.44818600
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44252512
47Insulin secretion_Homo sapiens_hsa049111.44159613
48Parkinsons disease_Homo sapiens_hsa050121.44068358
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42412536
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41660829
51Glioma_Homo sapiens_hsa052141.38595441
52Dilated cardiomyopathy_Homo sapiens_hsa054141.38074984
53Melanogenesis_Homo sapiens_hsa049161.37238586
54Basal transcription factors_Homo sapiens_hsa030221.36937912
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.36633419
56Folate biosynthesis_Homo sapiens_hsa007901.33288355
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31618824
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31528142
59Estrogen signaling pathway_Homo sapiens_hsa049151.29059577
60RNA degradation_Homo sapiens_hsa030181.27825455
61Biosynthesis of amino acids_Homo sapiens_hsa012301.26554611
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24807440
63Fatty acid elongation_Homo sapiens_hsa000621.24759845
64* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24580081
65Calcium signaling pathway_Homo sapiens_hsa040201.24457425
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21683698
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20784130
68Huntingtons disease_Homo sapiens_hsa050161.20523904
69Pyruvate metabolism_Homo sapiens_hsa006201.20101004
70Butanoate metabolism_Homo sapiens_hsa006501.17300366
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13309781
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13069715
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12359236
74Cardiac muscle contraction_Homo sapiens_hsa042601.12152478
75Oocyte meiosis_Homo sapiens_hsa041141.10704811
76mRNA surveillance pathway_Homo sapiens_hsa030151.08985240
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08743010
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08582991
79ErbB signaling pathway_Homo sapiens_hsa040121.08280668
80Focal adhesion_Homo sapiens_hsa045101.06835055
81Vitamin B6 metabolism_Homo sapiens_hsa007501.04584639
82Pyrimidine metabolism_Homo sapiens_hsa002401.04108693
83ECM-receptor interaction_Homo sapiens_hsa045121.03723404
84cAMP signaling pathway_Homo sapiens_hsa040241.02486631
85Hippo signaling pathway_Homo sapiens_hsa043901.02434525
86Vibrio cholerae infection_Homo sapiens_hsa051101.00293188
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99917934
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97529507
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.96471686
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96470514
91Thyroid hormone synthesis_Homo sapiens_hsa049180.94698664
92Alzheimers disease_Homo sapiens_hsa050100.92708074
93One carbon pool by folate_Homo sapiens_hsa006700.91998275
94Hedgehog signaling pathway_Homo sapiens_hsa043400.91356304
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90655530
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.90349983
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90248019
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89839284
99Rap1 signaling pathway_Homo sapiens_hsa040150.89429676
100Proteoglycans in cancer_Homo sapiens_hsa052050.89092230
101Carbon metabolism_Homo sapiens_hsa012000.88973695
102Wnt signaling pathway_Homo sapiens_hsa043100.88936920
103Dorso-ventral axis formation_Homo sapiens_hsa043200.86888073
104Collecting duct acid secretion_Homo sapiens_hsa049660.86640365
105Melanoma_Homo sapiens_hsa052180.86247987
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83556067
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81798324
108Adherens junction_Homo sapiens_hsa045200.81710506
109Type II diabetes mellitus_Homo sapiens_hsa049300.81353894
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81199490
111Endometrial cancer_Homo sapiens_hsa052130.80946490
112Fatty acid metabolism_Homo sapiens_hsa012120.80807314
113MAPK signaling pathway_Homo sapiens_hsa040100.80739570
114TGF-beta signaling pathway_Homo sapiens_hsa043500.80356874
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.80003207
116Arginine and proline metabolism_Homo sapiens_hsa003300.78892748
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77076343
118Purine metabolism_Homo sapiens_hsa002300.76869623
119Sulfur relay system_Homo sapiens_hsa041220.76296048
120Choline metabolism in cancer_Homo sapiens_hsa052310.73107950
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73091943
122Colorectal cancer_Homo sapiens_hsa052100.72544361
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72479798
124Tight junction_Homo sapiens_hsa045300.72445609
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71617510
126Amoebiasis_Homo sapiens_hsa051460.71615902
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70619942
128Renal cell carcinoma_Homo sapiens_hsa052110.70373498
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68818510
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68692065
131Ovarian steroidogenesis_Homo sapiens_hsa049130.68098549
132Ras signaling pathway_Homo sapiens_hsa040140.67950592
133Basal cell carcinoma_Homo sapiens_hsa052170.67906565
134mTOR signaling pathway_Homo sapiens_hsa041500.67508800
135Selenocompound metabolism_Homo sapiens_hsa004500.67328711
136Ribosome_Homo sapiens_hsa030100.66529300
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66088641
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65529405
139Bladder cancer_Homo sapiens_hsa052190.65444072
140VEGF signaling pathway_Homo sapiens_hsa043700.64644660
141Alcoholism_Homo sapiens_hsa050340.64404947
142Peroxisome_Homo sapiens_hsa041460.63631108
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63058298
144MicroRNAs in cancer_Homo sapiens_hsa052060.59122107
145Non-small cell lung cancer_Homo sapiens_hsa052230.58071935
146Protein digestion and absorption_Homo sapiens_hsa049740.56793283
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56117695
148Phototransduction_Homo sapiens_hsa047440.55661027
149p53 signaling pathway_Homo sapiens_hsa041150.55099463
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54434706
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53992552
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53581347
153Glucagon signaling pathway_Homo sapiens_hsa049220.53178597
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52864063
155Metabolic pathways_Homo sapiens_hsa011000.52816118
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51386154
157Insulin signaling pathway_Homo sapiens_hsa049100.50467132
158N-Glycan biosynthesis_Homo sapiens_hsa005100.49870019
159beta-Alanine metabolism_Homo sapiens_hsa004100.49124481
160Platelet activation_Homo sapiens_hsa046110.47793318
161Endocytosis_Homo sapiens_hsa041440.47530142
162Pancreatic secretion_Homo sapiens_hsa049720.47486958
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47202128
164Lysine degradation_Homo sapiens_hsa003100.42380513
165Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37272511
166Glutathione metabolism_Homo sapiens_hsa004800.37249187
167Nitrogen metabolism_Homo sapiens_hsa009100.34243831
168Thyroid cancer_Homo sapiens_hsa052160.28934006
169Fatty acid biosynthesis_Homo sapiens_hsa000610.28475627
170Circadian rhythm_Homo sapiens_hsa047100.28403123

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