HS6ST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.17281751
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04306646
3synaptic vesicle maturation (GO:0016188)6.01791482
4cornea development in camera-type eye (GO:0061303)5.99895024
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.93764808
6vocalization behavior (GO:0071625)5.64670572
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51073836
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.48356710
9regulation of glutamate receptor signaling pathway (GO:1900449)5.10288820
10synaptic vesicle exocytosis (GO:0016079)4.99629877
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.97322208
12protein localization to synapse (GO:0035418)4.92078878
13exploration behavior (GO:0035640)4.91606432
14glutamate secretion (GO:0014047)4.91280929
15astrocyte differentiation (GO:0048708)4.90861160
16regulation of synapse structural plasticity (GO:0051823)4.86015688
17layer formation in cerebral cortex (GO:0021819)4.79385925
18regulation of synaptic vesicle exocytosis (GO:2000300)4.75347074
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.69232897
20dendritic spine morphogenesis (GO:0060997)4.67626471
21neuron cell-cell adhesion (GO:0007158)4.65252980
22neurotransmitter-gated ion channel clustering (GO:0072578)4.59441388
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.57368984
24regulation of neuronal synaptic plasticity (GO:0048168)4.51880489
25negative regulation of dendrite morphogenesis (GO:0050774)4.46875838
26neurotransmitter secretion (GO:0007269)4.20821389
27synaptic transmission, glutamatergic (GO:0035249)4.19690796
28regulation of synaptic vesicle transport (GO:1902803)4.19181201
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09594907
30glutamate receptor signaling pathway (GO:0007215)4.05133449
31proline transport (GO:0015824)4.04287207
32positive regulation of membrane potential (GO:0045838)4.00933351
33neuron-neuron synaptic transmission (GO:0007270)3.95933714
34positive regulation of synapse maturation (GO:0090129)3.92381295
35long-term memory (GO:0007616)3.85304247
36regulation of timing of cell differentiation (GO:0048505)3.84474745
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81010669
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80782383
39auditory behavior (GO:0031223)3.79717264
40gamma-aminobutyric acid transport (GO:0015812)3.77994662
41regulation of dendritic spine morphogenesis (GO:0061001)3.77854268
42postsynaptic membrane organization (GO:0001941)3.77633367
43activation of protein kinase A activity (GO:0034199)3.77022368
44neuronal action potential propagation (GO:0019227)3.76013433
45startle response (GO:0001964)3.70909784
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70899420
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.69118342
48neuron recognition (GO:0008038)3.66613761
49negative regulation of dendrite development (GO:2000171)3.66598183
50neuromuscular process controlling balance (GO:0050885)3.65828904
51regulation of postsynaptic membrane potential (GO:0060078)3.64269042
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62222550
53dendrite morphogenesis (GO:0048813)3.60412537
54regulation of synaptic plasticity (GO:0048167)3.58919661
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.55000683
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54746651
57glandular epithelial cell differentiation (GO:0002067)3.47297399
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47144203
59innervation (GO:0060384)3.47028377
60detection of calcium ion (GO:0005513)3.46995676
61axonal fasciculation (GO:0007413)3.44346680
62insulin secretion (GO:0030073)3.42915068
63hindbrain development (GO:0030902)3.39598894
64dendritic spine organization (GO:0097061)3.38803208
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.37863286
66response to auditory stimulus (GO:0010996)3.36423680
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36268103
68cellular potassium ion homeostasis (GO:0030007)3.32328775
69transmission of nerve impulse (GO:0019226)3.31740213
70regulation of development, heterochronic (GO:0040034)3.30177786
71neurotransmitter transport (GO:0006836)3.27076685
72regulation of calcium ion-dependent exocytosis (GO:0017158)3.24765000
73presynaptic membrane assembly (GO:0097105)3.24001471
74potassium ion homeostasis (GO:0055075)3.23411656
75glandular epithelial cell development (GO:0002068)3.22725592
76vesicle transport along microtubule (GO:0047496)3.21063894
77cerebellar granule cell differentiation (GO:0021707)3.20798733
78positive regulation of neurotransmitter secretion (GO:0001956)3.20651814
79potassium ion import (GO:0010107)3.18502312
80positive regulation of cell fate commitment (GO:0010455)3.18052927
81positive regulation of dendritic spine morphogenesis (GO:0061003)3.17837130
82regulation of ARF protein signal transduction (GO:0032012)3.17363394
83prepulse inhibition (GO:0060134)3.16930736
84long-term synaptic potentiation (GO:0060291)3.16678927
85behavioral fear response (GO:0001662)3.16222176
86behavioral defense response (GO:0002209)3.16222176
87positive regulation of dendritic spine development (GO:0060999)3.15083505
88sodium ion export (GO:0071436)3.15016517
89regulation of dendritic spine development (GO:0060998)3.14943607
90regulation of vesicle fusion (GO:0031338)3.13190812
91regulation of neurotransmitter secretion (GO:0046928)3.13058949
92positive regulation of neurotransmitter transport (GO:0051590)3.12883810
93cerebellar Purkinje cell layer development (GO:0021680)3.12322310
94regulation of neurotransmitter transport (GO:0051588)3.12082997
95response to histamine (GO:0034776)3.11796450
96negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10217575
97synapse assembly (GO:0007416)3.10212415
98central nervous system projection neuron axonogenesis (GO:0021952)3.09972362
99learning (GO:0007612)3.08845526
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08674665
101glycine transport (GO:0015816)3.07062495
102organelle transport along microtubule (GO:0072384)3.05821937
103neuronal ion channel clustering (GO:0045161)3.05241104
104mechanosensory behavior (GO:0007638)3.04756616
105regulation of neurotransmitter levels (GO:0001505)3.04713367
106synaptic vesicle endocytosis (GO:0048488)3.03684906
107membrane depolarization (GO:0051899)3.03067719
108dorsal/ventral axis specification (GO:0009950)3.02444106
109regulation of hexokinase activity (GO:1903299)3.01589449
110regulation of glucokinase activity (GO:0033131)3.01589449
111membrane depolarization during action potential (GO:0086010)3.01452152
112cell communication by electrical coupling (GO:0010644)3.00557238
113chemosensory behavior (GO:0007635)3.00025939
114neuromuscular process (GO:0050905)2.99985248
115membrane hyperpolarization (GO:0060081)2.99233246
116social behavior (GO:0035176)2.97518404
117intraspecies interaction between organisms (GO:0051703)2.97518404
118urinary tract smooth muscle contraction (GO:0014848)2.97494073
119regulation of female receptivity (GO:0045924)2.96509348
120signal release (GO:0023061)2.95561702
121presynaptic membrane organization (GO:0097090)2.95217595
122cell migration in hindbrain (GO:0021535)2.95188944
123gamma-aminobutyric acid signaling pathway (GO:0007214)2.94360623
124fear response (GO:0042596)2.93679065
125regulation of synapse maturation (GO:0090128)2.93147707
126dopamine receptor signaling pathway (GO:0007212)2.92450058
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90455595
128righting reflex (GO:0060013)2.90245354
129synaptic transmission (GO:0007268)2.89199799
130neuromuscular process controlling posture (GO:0050884)2.87154749
131neuromuscular synaptic transmission (GO:0007274)2.85875882
132cochlea development (GO:0090102)2.77621529
133calcium ion-dependent exocytosis (GO:0017156)2.73177035
134serotonin metabolic process (GO:0042428)2.72807882
135macroautophagy (GO:0016236)2.71931066
136cellular potassium ion transport (GO:0071804)2.70472179
137potassium ion transmembrane transport (GO:0071805)2.70472179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99625408
2* GBX2_23144817_ChIP-Seq_PC3_Human3.44056428
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10197146
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05539881
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95840424
6REST_21632747_ChIP-Seq_MESCs_Mouse2.80027194
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.76509366
8DROSHA_22980978_ChIP-Seq_HELA_Human2.66113523
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61632653
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61632653
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59572330
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54476701
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53816409
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50400907
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.47427194
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41403437
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41007211
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.31005012
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25086819
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24763952
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21322902
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16232998
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11125938
24* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09405663
25* EED_16625203_ChIP-ChIP_MESCs_Mouse2.07230252
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05546240
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01865765
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99002786
29AR_21572438_ChIP-Seq_LNCaP_Human1.90565872
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84584255
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83618816
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74556454
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66711801
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66214983
35SMAD4_21799915_ChIP-Seq_A2780_Human1.61363289
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56320629
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54176310
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.53873505
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42342348
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42282268
41ZNF274_21170338_ChIP-Seq_K562_Hela1.41949011
42* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38939623
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35200995
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33872792
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33475017
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32395352
47* AR_19668381_ChIP-Seq_PC3_Human1.29500658
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26924053
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26090124
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25955942
51TAF15_26573619_Chip-Seq_HEK293_Human1.25795599
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25671121
53* STAT3_23295773_ChIP-Seq_U87_Human1.25246428
54HTT_18923047_ChIP-ChIP_STHdh_Human1.23855039
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22602007
56IGF1R_20145208_ChIP-Seq_DFB_Human1.21263340
57P300_19829295_ChIP-Seq_ESCs_Human1.21249246
58* KDM2B_26808549_Chip-Seq_K562_Human1.20229132
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18891710
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18646830
61* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18408664
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.17947889
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.17726051
64* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17153118
65AR_25329375_ChIP-Seq_VCAP_Human1.17087493
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17049704
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16875150
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13657697
69FUS_26573619_Chip-Seq_HEK293_Human1.13259248
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11198091
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10511787
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10392957
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09619273
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.09539649
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08892684
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08892684
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08775822
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08364785
79* TCF4_23295773_ChIP-Seq_U87_Human1.08191790
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06826245
81VDR_22108803_ChIP-Seq_LS180_Human1.06713650
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06250234
83* AHR_22903824_ChIP-Seq_MCF-7_Human1.05545118
84* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04589573
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.04423846
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04276886
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.04225591
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04211838
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.03923901
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03132482
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01832130
92* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01813883
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01576138
94SMAD3_21741376_ChIP-Seq_ESCs_Human1.01381997
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01167437
96TP53_16413492_ChIP-PET_HCT116_Human1.00154631
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00120262
98* FLI1_21867929_ChIP-Seq_TH2_Mouse0.99881968
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.99615211
100BCAT_22108803_ChIP-Seq_LS180_Human0.98604337
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.98261646
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97516832
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96934078
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96873630
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.96221054
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95793106
107KDM2B_26808549_Chip-Seq_REH_Human0.95034019
108* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92850210
109* CBP_20019798_ChIP-Seq_JUKART_Human0.92850210
110P53_22387025_ChIP-Seq_ESCs_Mouse0.91673673
111ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91207797
112RUNX2_22187159_ChIP-Seq_PCA_Human0.90975320
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89803810
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89320061
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89257693
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88613327
117* RNF2_27304074_Chip-Seq_NSC_Mouse0.88413551
118JUN_21703547_ChIP-Seq_K562_Human0.88332298
119* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88207102
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87824873
121* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87700856
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87589496
123RXR_22108803_ChIP-Seq_LS180_Human0.86926620
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86510979
125* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85663298
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.85110393
127* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84035383
128BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83973671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.00117662
2MP0004270_analgesia4.28714261
3MP0003635_abnormal_synaptic_transmissio4.24129136
4MP0003880_abnormal_central_pattern4.14964431
5MP0002638_abnormal_pupillary_reflex4.13195388
6MP0006292_abnormal_olfactory_placode4.13016677
7MP0005257_abnormal_intraocular_pressure3.52700297
8MP0002063_abnormal_learning/memory/cond3.47792928
9MP0009745_abnormal_behavioral_response3.36191989
10MP0002822_catalepsy3.29331119
11MP0002064_seizures2.99713396
12MP0009780_abnormal_chondrocyte_physiolo2.89689705
13MP0005423_abnormal_somatic_nervous2.84789425
14MP0002734_abnormal_mechanical_nocicepti2.80511699
15MP0002572_abnormal_emotion/affect_behav2.79666478
16MP0009046_muscle_twitch2.75282830
17MP0001968_abnormal_touch/_nociception2.72254985
18MP0008877_abnormal_DNA_methylation2.67875816
19MP0001486_abnormal_startle_reflex2.46984186
20MP0002272_abnormal_nervous_system2.35264206
21MP0002909_abnormal_adrenal_gland2.33582129
22MP0002735_abnormal_chemical_nociception2.20280218
23MP0002733_abnormal_thermal_nociception2.07584679
24MP0001501_abnormal_sleep_pattern2.01688929
25MP0000778_abnormal_nervous_system1.95668188
26MP0003879_abnormal_hair_cell1.94714923
27MP0001970_abnormal_pain_threshold1.93957633
28MP0002736_abnormal_nociception_after1.93521317
29MP0004858_abnormal_nervous_system1.92697888
30MP0004811_abnormal_neuron_physiology1.92626722
31MP0008789_abnormal_olfactory_epithelium1.90681251
32MP0001440_abnormal_grooming_behavior1.90555008
33MP0003121_genomic_imprinting1.83798758
34MP0002184_abnormal_innervation1.82397198
35MP0003329_amyloid_beta_deposits1.80919106
36MP0002557_abnormal_social/conspecific_i1.79019301
37MP0008569_lethality_at_weaning1.77218623
38MP0005386_behavior/neurological_phenoty1.76923100
39MP0004924_abnormal_behavior1.76923100
40MP0002938_white_spotting1.75688461
41MP0002067_abnormal_sensory_capabilities1.74407440
42MP0000955_abnormal_spinal_cord1.65461315
43MP0005646_abnormal_pituitary_gland1.65336963
44MP0003283_abnormal_digestive_organ1.64434017
45MP0004885_abnormal_endolymph1.59643352
46MP0003633_abnormal_nervous_system1.45008349
47MP0005645_abnormal_hypothalamus_physiol1.43618002
48MP0002882_abnormal_neuron_morphology1.40905364
49MP0002066_abnormal_motor_capabilities/c1.39943549
50MP0001944_abnormal_pancreas_morphology1.39113439
51MP0000569_abnormal_digit_pigmentation1.38462333
52MP0003123_paternal_imprinting1.37553258
53MP0003787_abnormal_imprinting1.34179126
54MP0001529_abnormal_vocalization1.33009142
55MP0001984_abnormal_olfaction1.25893185
56MP0000013_abnormal_adipose_tissue1.25828931
57MP0006276_abnormal_autonomic_nervous1.17817945
58MP0003631_nervous_system_phenotype1.16610351
59MP0002152_abnormal_brain_morphology1.13944471
60MP0002876_abnormal_thyroid_physiology1.13458821
61MP0002160_abnormal_reproductive_system1.11177692
62MP0008961_abnormal_basal_metabolism1.10887342
63MP0001502_abnormal_circadian_rhythm1.05367032
64MP0002693_abnormal_pancreas_physiology1.04354252
65MP0003122_maternal_imprinting1.03944988
66MP0010386_abnormal_urinary_bladder1.00815434
67MP0000613_abnormal_salivary_gland1.00446777
68MP0001188_hyperpigmentation0.98436891
69MP0001177_atelectasis0.95613295
70MP0001905_abnormal_dopamine_level0.95100364
71MP0002069_abnormal_eating/drinking_beha0.94999170
72MP0004142_abnormal_muscle_tone0.93948316
73MP0002837_dystrophic_cardiac_calcinosis0.90958579
74MP0002229_neurodegeneration0.89782774
75MP0008874_decreased_physiological_sensi0.89187607
76MP0003075_altered_response_to0.87944546
77MP0003634_abnormal_glial_cell0.87238617
78MP0003172_abnormal_lysosome_physiology0.84114818
79MP0004085_abnormal_heartbeat0.83873683
80MP0000631_abnormal_neuroendocrine_gland0.83607889
81MP0004133_heterotaxia0.80473109
82MP0005535_abnormal_body_temperature0.79040137
83MP0008872_abnormal_physiological_respon0.78079697
84MP0002234_abnormal_pharynx_morphology0.77765113
85MP0000604_amyloidosis0.77385570
86MP0003632_abnormal_nervous_system0.76838233
87MP0004145_abnormal_muscle_electrophysio0.75517356
88MP0001348_abnormal_lacrimal_gland0.74282701
89MP0001299_abnormal_eye_distance/0.73608560
90MP0005187_abnormal_penis_morphology0.72723616
91MP0005409_darkened_coat_color0.70976405
92MP0001919_abnormal_reproductive_system0.69390815
93MP0003690_abnormal_glial_cell0.68073021
94MP0004742_abnormal_vestibular_system0.67891045
95MP0002078_abnormal_glucose_homeostasis0.67078099
96MP0005394_taste/olfaction_phenotype0.66014206
97MP0005499_abnormal_olfactory_system0.66014206
98MP0005551_abnormal_eye_electrophysiolog0.65227594
99MP0002090_abnormal_vision0.65149978
100MP0010234_abnormal_vibrissa_follicle0.64812539
101MP0006072_abnormal_retinal_apoptosis0.64632390
102MP0001963_abnormal_hearing_physiology0.64376987
103MP0005448_abnormal_energy_balance0.63686605
104MP0000920_abnormal_myelination0.63443949
105MP0010678_abnormal_skin_adnexa0.63250106
106MP0004043_abnormal_pH_regulation0.62745200
107MP0005379_endocrine/exocrine_gland_phen0.62591244
108MP0004130_abnormal_muscle_cell0.62003343
109MP0002752_abnormal_somatic_nervous0.61744406
110MP0004510_myositis0.61706134
111MP0000751_myopathy0.61192407
112MP0003861_abnormal_nervous_system0.60099559
113MP0001986_abnormal_taste_sensitivity0.60001471
114MP0005389_reproductive_system_phenotype0.58417827
115MP0001664_abnormal_digestion0.55835309
116MP0003938_abnormal_ear_development0.55724863
117MP0000383_abnormal_hair_follicle0.55706908
118MP0001765_abnormal_ion_homeostasis0.55243878
119MP0001756_abnormal_urination0.55130082
120MP0004233_abnormal_muscle_weight0.54552700
121MP0001485_abnormal_pinna_reflex0.54435894
122MP0001943_abnormal_respiration0.53582202
123MP0010769_abnormal_survival0.53194814
124MP0003137_abnormal_impulse_conducting0.52791606
125MP0010770_preweaning_lethality0.51790793
126MP0002082_postnatal_lethality0.51790793

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.87193114
2Myokymia (HP:0002411)6.80932373
3Aplasia/Hypoplasia of the fovea (HP:0008060)5.93694521
4Hypoplasia of the fovea (HP:0007750)5.93694521
5Focal seizures (HP:0007359)5.29783776
6Visual hallucinations (HP:0002367)4.94739569
7Abnormality of the fovea (HP:0000493)4.69256894
8Epileptic encephalopathy (HP:0200134)4.52312678
9Papilledema (HP:0001085)3.92653230
10Progressive cerebellar ataxia (HP:0002073)3.85134064
11Action tremor (HP:0002345)3.82835757
12Aplasia/Hypoplasia of the macula (HP:0008059)3.80050813
13Supranuclear gaze palsy (HP:0000605)3.79139383
14Absence seizures (HP:0002121)3.68112020
15Ankle clonus (HP:0011448)3.64397070
16Poor eye contact (HP:0000817)3.62387931
17Atonic seizures (HP:0010819)3.60792571
18Mutism (HP:0002300)3.57060813
19Broad-based gait (HP:0002136)3.56456991
20Febrile seizures (HP:0002373)3.54428219
21Aplasia/Hypoplasia affecting the retina (HP:0008061)3.53066441
22Generalized tonic-clonic seizures (HP:0002069)3.51049134
23Difficulty running (HP:0009046)3.38550848
24Hyperinsulinemic hypoglycemia (HP:0000825)3.38015461
25Hyperventilation (HP:0002883)3.34435240
26Dialeptic seizures (HP:0011146)3.32457092
27Urinary bladder sphincter dysfunction (HP:0002839)3.24842119
28Abnormal social behavior (HP:0012433)3.22087684
29Impaired social interactions (HP:0000735)3.22087684
30Depression (HP:0000716)3.21836156
31Impaired vibration sensation in the lower limbs (HP:0002166)3.12656883
32Epileptiform EEG discharges (HP:0011182)3.02693230
33Gaze-evoked nystagmus (HP:0000640)3.02436428
34Dysdiadochokinesis (HP:0002075)3.02032394
35Drooling (HP:0002307)3.01123686
36Excessive salivation (HP:0003781)3.01123686
37Optic nerve hypoplasia (HP:0000609)2.97970959
38Torticollis (HP:0000473)2.96252453
39Anxiety (HP:0000739)2.95878764
40Postural instability (HP:0002172)2.93527199
41Truncal ataxia (HP:0002078)2.92658531
42EEG with generalized epileptiform discharges (HP:0011198)2.89796685
43Cerebral inclusion bodies (HP:0100314)2.88808768
44Genetic anticipation (HP:0003743)2.88547280
45Neurofibrillary tangles (HP:0002185)2.85861101
46Impaired smooth pursuit (HP:0007772)2.81891620
47Hypsarrhythmia (HP:0002521)2.80618110
48Hypoglycemic coma (HP:0001325)2.79933813
49Status epilepticus (HP:0002133)2.78530090
50Dysmetria (HP:0001310)2.77623637
51Abnormality of binocular vision (HP:0011514)2.72988525
52Diplopia (HP:0000651)2.72988525
53Focal dystonia (HP:0004373)2.68468587
54Congenital glaucoma (HP:0001087)2.68341961
55Abnormality of the lower motor neuron (HP:0002366)2.68043084
56Hypoglycemic seizures (HP:0002173)2.67740197
57Megalencephaly (HP:0001355)2.66341010
58Abnormal eating behavior (HP:0100738)2.66236733
59Urinary urgency (HP:0000012)2.64872899
60Hemiparesis (HP:0001269)2.62970182
61Amyotrophic lateral sclerosis (HP:0007354)2.62857847
62Abnormality of the corticospinal tract (HP:0002492)2.61209679
63Spastic gait (HP:0002064)2.60608237
64Amblyopia (HP:0000646)2.58551306
65Stereotypic behavior (HP:0000733)2.56896773
66Intention tremor (HP:0002080)2.54633845
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.53039202
68Obstructive sleep apnea (HP:0002870)2.52300494
69Tetraplegia (HP:0002445)2.52254518
70Termporal pattern (HP:0011008)2.49533046
71Insidious onset (HP:0003587)2.49533046
72Bradykinesia (HP:0002067)2.45977918
73Mask-like facies (HP:0000298)2.45857424
74Craniofacial dystonia (HP:0012179)2.42954517
75Pheochromocytoma (HP:0002666)2.41908425
76Abnormality of ocular smooth pursuit (HP:0000617)2.39229763
77Agitation (HP:0000713)2.38683928
78Progressive inability to walk (HP:0002505)2.38147592
79Congenital malformation of the right heart (HP:0011723)2.35907714
80Double outlet right ventricle (HP:0001719)2.35907714
81Fetal akinesia sequence (HP:0001989)2.31035197
82Akinesia (HP:0002304)2.29811790
83Scanning speech (HP:0002168)2.29238990
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.28519412
85Resting tremor (HP:0002322)2.25095189
86Inappropriate behavior (HP:0000719)2.24729753
87Optic nerve coloboma (HP:0000588)2.24222654
88Ankyloglossia (HP:0010296)2.22501539
89Dysmetric saccades (HP:0000641)2.22202308
90Limb dystonia (HP:0002451)2.21374710
91Impaired vibratory sensation (HP:0002495)2.20891599
92Lower limb muscle weakness (HP:0007340)2.16321862
93Hemiplegia (HP:0002301)2.15603909
94Abnormality of the aortic arch (HP:0012303)2.15306526
95Intestinal atresia (HP:0011100)2.13642450
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12698322
97Degeneration of the lateral corticospinal tracts (HP:0002314)2.12698322
98Lower limb amyotrophy (HP:0007210)2.11757769
99Blue irides (HP:0000635)2.11333164
100Insomnia (HP:0100785)2.10516533
101Clonus (HP:0002169)2.08866564
102Pointed chin (HP:0000307)2.07267378
103Inability to walk (HP:0002540)2.04502963
104Apathy (HP:0000741)2.03802453
105Absent speech (HP:0001344)2.03788826
106Neuroendocrine neoplasm (HP:0100634)2.03046921
107Generalized myoclonic seizures (HP:0002123)2.00795475
108Polyphagia (HP:0002591)2.00772743
109Ventricular fibrillation (HP:0001663)1.99654915
110Abnormality of salivation (HP:0100755)1.98257928
111Diminished movement (HP:0002374)1.97305565
112Intellectual disability, profound (HP:0002187)1.96472406
113Aqueductal stenosis (HP:0002410)1.94408958
114Papillary thyroid carcinoma (HP:0002895)1.93996335
115Hyperglycemia (HP:0003074)1.93182890
116Generalized hyperpigmentation (HP:0007440)1.92711802
117Annular pancreas (HP:0001734)1.89527771
118Ketoacidosis (HP:0001993)1.89156923
119Macroorchidism (HP:0000053)1.89077467
120Neuronal loss in central nervous system (HP:0002529)1.87870735
121Increased circulating renin level (HP:0000848)1.87501335
122Aplasia/Hypoplasia of the lens (HP:0008063)1.85927321
123Enlarged penis (HP:0000040)1.85337254
124Neoplasm of the peripheral nervous system (HP:0100007)1.85293291
125Spastic tetraplegia (HP:0002510)1.84029702
126Hepatoblastoma (HP:0002884)1.83312151
127Morphological abnormality of the pyramidal tract (HP:0002062)1.81497228
128Muscular hypotonia of the trunk (HP:0008936)1.80279751
129Gait ataxia (HP:0002066)1.79281718
130Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.79273431
131Abnormal EKG (HP:0003115)1.78272507
132Diminished motivation (HP:0000745)1.74840625
133Incomplete penetrance (HP:0003829)1.74367155
134Rigidity (HP:0002063)1.74127733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.89924032
2EPHA44.21861012
3NTRK34.11448082
4MAP3K93.85738145
5MAP3K42.73085381
6MINK12.63941072
7DAPK22.58599624
8PRKD32.49660311
9NTRK22.41550702
10NTRK12.21707816
11HIPK22.19024699
12PAK62.16278015
13MAP2K72.11660571
14CAMKK12.06598977
15KSR21.95336900
16DAPK11.78076168
17CASK1.76537013
18KSR11.76513295
19MAP2K41.64276090
20CDK51.61218704
21MAP3K21.56754667
22RIPK41.47446237
23MAPK131.46244327
24IRAK21.42114152
25PHKG21.40554873
26PHKG11.40554873
27SIK21.39776632
28PRPF4B1.35992002
29MAP3K121.25715279
30TAOK11.24083578
31LATS21.23791316
32TNIK1.23516553
33PRKCG1.19395605
34UHMK11.14775106
35CAMKK21.12261571
36TYRO31.10243087
37PLK21.06965787
38WNK31.01420163
39GRK51.01170399
40FES1.00654481
41MARK20.97157975
42CDK190.97066203
43STK380.96546596
44RET0.95404941
45SCYL20.93865941
46PRKCH0.92529808
47STK110.92382716
48CAMK2A0.90657088
49GRK10.89721054
50CDK180.87466463
51CDK150.86579151
52ALK0.85958536
53CDK140.82883886
54CAMK2B0.79840625
55CSNK1G20.79550460
56CAMK10.79234826
57PNCK0.77697994
58CDK11A0.75368977
59PAK30.74410800
60SGK2230.73890054
61SGK4940.73890054
62STK38L0.71800228
63RIPK10.70479955
64SGK10.69013364
65CDK30.67831742
66PRKCZ0.65484640
67PDK10.64345906
68SGK20.63017168
69SGK30.62736816
70FRK0.61746040
71RAF10.60920321
72FYN0.60109981
73ARAF0.58354603
74DYRK1A0.57762959
75PDPK10.57721903
76INSRR0.56110613
77RPS6KB10.54897918
78DYRK20.54632232
79MAP3K10.54528386
80RPS6KA30.52678308
81LMTK20.50993180
82STK240.50635292
83CAMK2G0.50599292
84PRKCE0.49348137
85ERBB30.47277561
86CDC42BPA0.46935746
87PTK2B0.46862074
88RPS6KA20.45291973
89CAMK1G0.44411022
90BMPR20.44166869
91BRSK10.42215750
92MAP3K130.42139581
93NEK60.41832374
94MAP3K60.41674757
95CCNB10.41435147
96MAPK100.40607195
97FGFR20.40596674
98CSNK1D0.40310734
99PKN10.38399261
100PRKAA10.38205149
101CSNK1G30.38070637
102CSNK1A10.37046787
103CSNK1G10.36892795
104MAPK120.36556213
105DMPK0.36252349
106PRKACA0.34851364
107PRKCB0.34453037
108PINK10.33786618
109PRKCA0.33171716
110PRKCI0.33118374
111CAMK40.32375898
112OXSR10.32342807
113MAP2K10.32249742
114PDGFRA0.31400153
115CSNK1E0.31141765
116MAP3K70.30992613
117GSK3B0.30566018
118CAMK2D0.30395270
119MAP2K60.29206304

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.05172622
2Nicotine addiction_Homo sapiens_hsa050333.32836757
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94965858
4Circadian entrainment_Homo sapiens_hsa047132.77933680
5Olfactory transduction_Homo sapiens_hsa047402.70668311
6Long-term potentiation_Homo sapiens_hsa047202.69669406
7GABAergic synapse_Homo sapiens_hsa047272.61189187
8Glutamatergic synapse_Homo sapiens_hsa047242.54864495
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52146051
10Vitamin B6 metabolism_Homo sapiens_hsa007502.50851066
11Morphine addiction_Homo sapiens_hsa050322.46639424
12Amphetamine addiction_Homo sapiens_hsa050312.46187244
13Dopaminergic synapse_Homo sapiens_hsa047282.25620752
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23026679
15Insulin secretion_Homo sapiens_hsa049112.21995039
16Salivary secretion_Homo sapiens_hsa049702.12972493
17Cholinergic synapse_Homo sapiens_hsa047252.09346322
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95057352
19Cocaine addiction_Homo sapiens_hsa050301.86200390
20Gastric acid secretion_Homo sapiens_hsa049711.85476899
21Renin secretion_Homo sapiens_hsa049241.71301961
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69462830
23Oxytocin signaling pathway_Homo sapiens_hsa049211.63168282
24Long-term depression_Homo sapiens_hsa047301.61590734
25Serotonergic synapse_Homo sapiens_hsa047261.57798992
26Taste transduction_Homo sapiens_hsa047421.56445745
27Type II diabetes mellitus_Homo sapiens_hsa049301.53708162
28Calcium signaling pathway_Homo sapiens_hsa040201.50499986
29Gap junction_Homo sapiens_hsa045401.45141111
30GnRH signaling pathway_Homo sapiens_hsa049121.45092952
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44528105
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41497815
33Axon guidance_Homo sapiens_hsa043601.31391240
34Estrogen signaling pathway_Homo sapiens_hsa049151.31335671
35Glioma_Homo sapiens_hsa052141.30532275
36cAMP signaling pathway_Homo sapiens_hsa040241.29178544
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27404539
38Butanoate metabolism_Homo sapiens_hsa006501.11171289
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10751083
40ErbB signaling pathway_Homo sapiens_hsa040121.10589472
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09572197
42Melanogenesis_Homo sapiens_hsa049161.08828693
43Collecting duct acid secretion_Homo sapiens_hsa049660.99505740
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.96636766
45Nitrogen metabolism_Homo sapiens_hsa009100.93586040
46* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92566844
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88154628
48Pancreatic secretion_Homo sapiens_hsa049720.87851111
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.87328408
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86482176
51Oocyte meiosis_Homo sapiens_hsa041140.85890965
52Thyroid hormone synthesis_Homo sapiens_hsa049180.83664904
53Vibrio cholerae infection_Homo sapiens_hsa051100.83197409
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82407869
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82360479
56Dorso-ventral axis formation_Homo sapiens_hsa043200.81172158
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81167443
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79474333
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.75978347
60Dilated cardiomyopathy_Homo sapiens_hsa054140.74528129
61Choline metabolism in cancer_Homo sapiens_hsa052310.73997969
62mTOR signaling pathway_Homo sapiens_hsa041500.73945228
63Oxidative phosphorylation_Homo sapiens_hsa001900.73456321
64Alzheimers disease_Homo sapiens_hsa050100.73151916
65MAPK signaling pathway_Homo sapiens_hsa040100.70795368
66Folate biosynthesis_Homo sapiens_hsa007900.69199296
67Endometrial cancer_Homo sapiens_hsa052130.68756580
68Phototransduction_Homo sapiens_hsa047440.68475077
69Type I diabetes mellitus_Homo sapiens_hsa049400.67735830
70VEGF signaling pathway_Homo sapiens_hsa043700.65647016
71Glucagon signaling pathway_Homo sapiens_hsa049220.64396025
72Ras signaling pathway_Homo sapiens_hsa040140.63538095
73Rap1 signaling pathway_Homo sapiens_hsa040150.61826737
74Alcoholism_Homo sapiens_hsa050340.61700784
75Cardiac muscle contraction_Homo sapiens_hsa042600.61468606
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60980020
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60718577
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.58404293
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58313857
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57038369
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56408668
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56106487
83Non-small cell lung cancer_Homo sapiens_hsa052230.54175393
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53850665
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53825687
86Endocytosis_Homo sapiens_hsa041440.53697331
87Renal cell carcinoma_Homo sapiens_hsa052110.53444696
88Prion diseases_Homo sapiens_hsa050200.52244549
89Insulin signaling pathway_Homo sapiens_hsa049100.51758171
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49921906
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49040274
92Bile secretion_Homo sapiens_hsa049760.48278835
93Wnt signaling pathway_Homo sapiens_hsa043100.47801808
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46507823
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43677335
96Inositol phosphate metabolism_Homo sapiens_hsa005620.43146218
97Mineral absorption_Homo sapiens_hsa049780.42576817
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42229062
99Colorectal cancer_Homo sapiens_hsa052100.40834469
100ABC transporters_Homo sapiens_hsa020100.39536052
101Ovarian steroidogenesis_Homo sapiens_hsa049130.39016974
102Circadian rhythm_Homo sapiens_hsa047100.38650593
103Chemokine signaling pathway_Homo sapiens_hsa040620.37719562
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37058438
105Prolactin signaling pathway_Homo sapiens_hsa049170.34101915
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32955749
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31816246
108Parkinsons disease_Homo sapiens_hsa050120.31000476
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30705664
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29431822
111Pentose phosphate pathway_Homo sapiens_hsa000300.28603732
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28272141
113Platelet activation_Homo sapiens_hsa046110.28181785
114AMPK signaling pathway_Homo sapiens_hsa041520.27397692
115African trypanosomiasis_Homo sapiens_hsa051430.27231278
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26642564
117Regulation of autophagy_Homo sapiens_hsa041400.25581833
118Ether lipid metabolism_Homo sapiens_hsa005650.24330514
119beta-Alanine metabolism_Homo sapiens_hsa004100.24217992
120Protein export_Homo sapiens_hsa030600.24024801
121Hippo signaling pathway_Homo sapiens_hsa043900.21337649
122Tight junction_Homo sapiens_hsa045300.19943993
123Tryptophan metabolism_Homo sapiens_hsa003800.19667513

Most similar genes based on co-expression Upload to Enrichr

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