HSBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)7.31986463
2regulation of telomere maintenance via telomerase (GO:0032210)7.31976637
3negative regulation of telomerase activity (GO:0051974)6.70442660
4regulation of helicase activity (GO:0051095)6.63986248
5DNA damage response, detection of DNA damage (GO:0042769)5.96705234
6DNA damage induced protein phosphorylation (GO:0006975)5.95194120
7synaptic vesicle exocytosis (GO:0016079)5.32932965
8telomere maintenance via telomerase (GO:0007004)4.76806683
9regulation of telomerase activity (GO:0051972)4.73463000
10regulation of telomere maintenance (GO:0032204)4.70302851
11neuron cell-cell adhesion (GO:0007158)4.63240758
12ventricular trabecula myocardium morphogenesis (GO:0003222)4.54586321
13glutamate secretion (GO:0014047)4.33096574
14regulation of synaptic vesicle exocytosis (GO:2000300)4.29750747
15ATP hydrolysis coupled proton transport (GO:0015991)4.26771160
16energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.26771160
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26565999
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23313207
19vocalization behavior (GO:0071625)4.22181636
20protein localization to synapse (GO:0035418)4.13383724
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13359427
22chaperone-mediated protein transport (GO:0072321)4.12319568
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.11023040
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04114064
25synaptic vesicle maturation (GO:0016188)4.00987790
26presynaptic membrane assembly (GO:0097105)3.97384817
27ATP synthesis coupled proton transport (GO:0015986)3.94913735
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94913735
29transferrin transport (GO:0033572)3.84705806
30regulation of synaptic vesicle transport (GO:1902803)3.79605851
31RNA-dependent DNA replication (GO:0006278)3.74015807
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72128743
33regulation of glutamate receptor signaling pathway (GO:1900449)3.72099272
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70939273
35respiratory electron transport chain (GO:0022904)3.68627141
36presynaptic membrane organization (GO:0097090)3.67806912
37postsynaptic membrane organization (GO:0001941)3.67049959
38negative regulation of DNA biosynthetic process (GO:2000279)3.66964444
39heart trabecula morphogenesis (GO:0061384)3.66690236
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65458439
41electron transport chain (GO:0022900)3.62616250
42neurotransmitter-gated ion channel clustering (GO:0072578)3.61656938
43intraciliary transport (GO:0042073)3.61157109
44ferric iron transport (GO:0015682)3.57107794
45trivalent inorganic cation transport (GO:0072512)3.57107794
46neurotransmitter secretion (GO:0007269)3.52563744
47sequestering of actin monomers (GO:0042989)3.51335920
48regulation of synapse structural plasticity (GO:0051823)3.46380188
49artery development (GO:0060840)3.45634671
50neuronal action potential propagation (GO:0019227)3.45350658
51negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.43626494
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40954281
53positive regulation of response to oxidative stress (GO:1902884)3.38225593
54positive regulation of cellular response to oxidative stress (GO:1900409)3.38225593
55protein localization to cilium (GO:0061512)3.37327427
56neuron-neuron synaptic transmission (GO:0007270)3.30194439
57protein complex biogenesis (GO:0070271)3.29333942
58cilium movement (GO:0003341)3.24349778
59protein polyglutamylation (GO:0018095)3.23251453
60protein deneddylation (GO:0000338)3.22029043
61cell migration in hindbrain (GO:0021535)3.20891381
62synaptic transmission, glutamatergic (GO:0035249)3.20488443
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.18298378
64protein neddylation (GO:0045116)3.18275896
65neuron recognition (GO:0008038)3.17845366
66locomotory exploration behavior (GO:0035641)3.14078222
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12640683
68ionotropic glutamate receptor signaling pathway (GO:0035235)3.11120104
69exploration behavior (GO:0035640)3.09771033
70long-term synaptic potentiation (GO:0060291)3.07417690
71cardiac right ventricle morphogenesis (GO:0003215)3.06319773
72hydrogen ion transmembrane transport (GO:1902600)3.02507601
73regulation of neuronal synaptic plasticity (GO:0048168)3.01913383
74calcium ion-dependent exocytosis (GO:0017156)3.01891844
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.00639960
76glutamate receptor signaling pathway (GO:0007215)2.99776182
77startle response (GO:0001964)2.99459548
78negative regulation of microtubule polymerization (GO:0031115)2.96404877
79phagosome maturation (GO:0090382)2.94930982
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94426595
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.94426595
82NADH dehydrogenase complex assembly (GO:0010257)2.94426595
83lymphangiogenesis (GO:0001946)2.94278095
84embryonic foregut morphogenesis (GO:0048617)2.92795233
85positive regulation of synapse assembly (GO:0051965)2.92461045
86synaptic vesicle transport (GO:0048489)2.92153764
87establishment of synaptic vesicle localization (GO:0097480)2.92153764
88neurotransmitter transport (GO:0006836)2.91313008
89positive regulation of membrane potential (GO:0045838)2.89621444
90mitochondrial respiratory chain complex assembly (GO:0033108)2.87387522
91single strand break repair (GO:0000012)2.87306309
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87107828
93regulation of vesicle fusion (GO:0031338)2.85752531
94nonmotile primary cilium assembly (GO:0035058)2.85242022
95positive regulation of TOR signaling (GO:0032008)2.84226017
96limb bud formation (GO:0060174)2.83139809
97regulation of neurotransmitter secretion (GO:0046928)2.82673279
98gamma-aminobutyric acid transport (GO:0015812)2.81055038
99regulation of glutamate secretion (GO:0014048)2.80711835
100transmission of nerve impulse (GO:0019226)2.80707512
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80650026
102nucleobase catabolic process (GO:0046113)2.80599630
103cullin deneddylation (GO:0010388)2.80262369
104chromatin remodeling at centromere (GO:0031055)2.78585325
105cilium morphogenesis (GO:0060271)2.77409036
106retinal ganglion cell axon guidance (GO:0031290)2.77200614
107neurotransmitter uptake (GO:0001504)2.75179713
108positive regulation of neurotransmitter transport (GO:0051590)2.74844631
109GTP biosynthetic process (GO:0006183)2.74712885
110negative regulation of striated muscle cell apoptotic process (GO:0010664)2.74564921
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73585655
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72768637
113mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.71451510
114positive regulation of neurotransmitter secretion (GO:0001956)2.71354300
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71305622
116regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70431269
117regulation of neurotransmitter levels (GO:0001505)2.70178209
118CENP-A containing nucleosome assembly (GO:0034080)2.69480021
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.69326590
120female mating behavior (GO:0060180)2.68557747
121response to histamine (GO:0034776)2.68373048
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68117958
123epithelial cilium movement (GO:0003351)2.67872218
124axonal fasciculation (GO:0007413)2.67730554
125negative regulation of dendrite morphogenesis (GO:0050774)2.67096824
126proline transport (GO:0015824)2.66917761
127establishment of vesicle localization (GO:0051650)2.66537789
128proton transport (GO:0015992)2.65041011
129brain morphogenesis (GO:0048854)2.64712961
130mechanosensory behavior (GO:0007638)2.64363643
131regulation of neurotransmitter transport (GO:0051588)2.64328692
132regulation of protein kinase A signaling (GO:0010738)2.64128207
133cell proliferation in forebrain (GO:0021846)2.63240572
134regulation of synaptic transmission, GABAergic (GO:0032228)2.62928302
135dendrite development (GO:0016358)2.62003744
136regulation of synaptic plasticity (GO:0048167)2.61529552
137pyrimidine nucleobase catabolic process (GO:0006208)2.61367617
138response to auditory stimulus (GO:0010996)2.61196327
139cerebellar granule cell differentiation (GO:0021707)2.60983944
140regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.60557567
141regulation of postsynaptic membrane potential (GO:0060078)2.60446298
142hydrogen transport (GO:0006818)2.60283300
143organ growth (GO:0035265)2.59294966
144respiratory chain complex IV assembly (GO:0008535)2.56670579
145neurofilament cytoskeleton organization (GO:0060052)2.56150037
146axoneme assembly (GO:0035082)2.55349134
147C4-dicarboxylate transport (GO:0015740)2.52517253
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52165263
149negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51300373
150DNA double-strand break processing (GO:0000729)2.51247988
151platelet dense granule organization (GO:0060155)2.50373697
152axonemal dynein complex assembly (GO:0070286)2.47473569
153DNA replication checkpoint (GO:0000076)2.47282535
154cerebral cortex neuron differentiation (GO:0021895)2.45121748
155nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44706988
156proteasome assembly (GO:0043248)2.44105072
157cilium organization (GO:0044782)2.41232076
158water-soluble vitamin biosynthetic process (GO:0042364)2.41175042
159L-serine metabolic process (GO:0006563)2.41171334
160cilium assembly (GO:0042384)2.40449584
161trabecula morphogenesis (GO:0061383)2.38866618
162detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38013155
163determination of left/right symmetry (GO:0007368)2.37573194
164layer formation in cerebral cortex (GO:0021819)2.37327364
165regulation of cilium movement (GO:0003352)2.36110800
166protein-cofactor linkage (GO:0018065)2.34256118
167exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33761980
168pancreas development (GO:0031016)2.32108290
169organelle disassembly (GO:1903008)2.31083718
170renal system development (GO:0072001)2.30075672
171positive regulation of mitochondrial fission (GO:0090141)2.29342540
172determination of bilateral symmetry (GO:0009855)2.29205182
173intra-S DNA damage checkpoint (GO:0031573)2.29088655
174heart field specification (GO:0003128)2.28428947
175secondary heart field specification (GO:0003139)2.28428947
176synapse assembly (GO:0007416)2.27861536
177behavioral response to nicotine (GO:0035095)2.27561660
178behavioral response to ethanol (GO:0048149)2.27152727
179activin receptor signaling pathway (GO:0032924)2.27141774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60833654
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.01781728
3GBX2_23144817_ChIP-Seq_PC3_Human3.95202715
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03426605
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.80563700
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76854738
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75059561
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.69237040
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64682316
10* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58387487
11TAF15_26573619_Chip-Seq_HEK293_Human2.55632315
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51795806
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50526485
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.41702396
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35148853
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.29991326
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.29606830
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28391651
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26272890
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22954633
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21732767
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20779841
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19361225
24EWS_26573619_Chip-Seq_HEK293_Human2.18184645
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13290920
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11891512
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04076038
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04076038
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04004636
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.02836204
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.98817162
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91039529
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90805417
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90523923
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.89620894
36ELK1_19687146_ChIP-ChIP_HELA_Human1.89075818
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80949230
38VDR_22108803_ChIP-Seq_LS180_Human1.80748600
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.78147809
40P300_19829295_ChIP-Seq_ESCs_Human1.77858164
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76046083
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75102929
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72622192
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68780123
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.66264038
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62522073
47* MYC_18940864_ChIP-ChIP_HL60_Human1.61899850
48SMAD4_21799915_ChIP-Seq_A2780_Human1.58869032
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58781750
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58197191
51FUS_26573619_Chip-Seq_HEK293_Human1.58151417
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.56431173
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53788109
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53237500
55RNF2_27304074_Chip-Seq_NSC_Mouse1.53172293
56ZNF274_21170338_ChIP-Seq_K562_Hela1.51981056
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48828127
58IGF1R_20145208_ChIP-Seq_DFB_Human1.45781503
59* ER_23166858_ChIP-Seq_MCF-7_Human1.45576704
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44252972
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43585673
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.42892939
63AR_21572438_ChIP-Seq_LNCaP_Human1.42382827
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41929667
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41841512
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41243318
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40043663
68* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39962697
69DROSHA_22980978_ChIP-Seq_HELA_Human1.37561945
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35019845
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33819437
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33282942
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.30971252
74AR_25329375_ChIP-Seq_VCAP_Human1.29187804
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.27868058
76JUN_21703547_ChIP-Seq_K562_Human1.27459944
77TP53_22573176_ChIP-Seq_HFKS_Human1.21325337
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19600346
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.18394319
80VDR_23849224_ChIP-Seq_CD4+_Human1.17494083
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17326896
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16851053
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15933352
84IRF1_19129219_ChIP-ChIP_H3396_Human1.15828107
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11496248
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.11410808
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10887159
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10429599
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10299987
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08381443
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06390831
92* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06115702
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05863601
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04752136
95TCF4_22108803_ChIP-Seq_LS180_Human1.04727585
96* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03743192
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.03370774
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03204768
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03111275
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03102167
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.01969227
102* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01911682
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01056934
104CBP_20019798_ChIP-Seq_JUKART_Human1.01056934
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.00684532
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00463051
107* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00461892
108* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99905320
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99771022
110TP63_19390658_ChIP-ChIP_HaCaT_Human0.99251932
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.99228685
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.99118574
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.98853287
114KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98451829
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98205961
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97829940
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96856971
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96186982
119FOXP3_21729870_ChIP-Seq_TREG_Human0.95413286
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94742234
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94742234
122STAT3_23295773_ChIP-Seq_U87_Human0.94309385
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94112147
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93937224
125P53_22387025_ChIP-Seq_ESCs_Mouse0.93712098
126* TCF4_23295773_ChIP-Seq_U87_Human0.92447692
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92443243
128MYC_18555785_ChIP-Seq_MESCs_Mouse0.92250877
129KDM2B_26808549_Chip-Seq_REH_Human0.91116967
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91084376
131E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90901376
132SOX9_26525672_Chip-Seq_HEART_Mouse0.90648133
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89948284
134HTT_18923047_ChIP-ChIP_STHdh_Human0.89881202
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.89519730
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89474625
137DCP1A_22483619_ChIP-Seq_HELA_Human0.89442034
138CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88704295
139* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87878724
140* GABP_19822575_ChIP-Seq_HepG2_Human0.87739454
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.86901712
142* CMYC_18555785_Chip-Seq_ESCs_Mouse0.86665740
143* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86468466
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.86155534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.93616340
2MP0004859_abnormal_synaptic_plasticity4.38928717
3MP0003635_abnormal_synaptic_transmissio3.47139496
4MP0004133_heterotaxia3.42568845
5MP0004270_analgesia3.22477790
6MP0002102_abnormal_ear_morphology3.06534855
7MP0001968_abnormal_touch/_nociception3.00045262
8MP0009745_abnormal_behavioral_response2.99185102
9MP0002064_seizures2.87878039
10MP0009046_muscle_twitch2.87188129
11MP0002063_abnormal_learning/memory/cond2.87178043
12MP0002736_abnormal_nociception_after2.73462930
13MP0002734_abnormal_mechanical_nocicepti2.69403899
14MP0002572_abnormal_emotion/affect_behav2.56375148
15MP0001529_abnormal_vocalization2.46681409
16MP0001984_abnormal_olfaction2.46494657
17MP0006276_abnormal_autonomic_nervous2.42423689
18MP0002272_abnormal_nervous_system2.40638509
19MP0002735_abnormal_chemical_nociception2.23796540
20MP0005423_abnormal_somatic_nervous2.20341470
21MP0001486_abnormal_startle_reflex2.16493012
22MP0001905_abnormal_dopamine_level2.16184212
23MP0003136_yellow_coat_color2.11862878
24MP0003122_maternal_imprinting2.09363773
25MP0003121_genomic_imprinting1.96483665
26MP0003890_abnormal_embryonic-extraembry1.95646941
27MP0000778_abnormal_nervous_system1.92955351
28MP0002733_abnormal_thermal_nociception1.91094762
29MP0005646_abnormal_pituitary_gland1.90185152
30MP0001970_abnormal_pain_threshold1.89734214
31MP0001440_abnormal_grooming_behavior1.88373150
32MP0002822_catalepsy1.87441016
33MP0002067_abnormal_sensory_capabilities1.86620538
34MP0005410_abnormal_fertilization1.76689848
35MP0001501_abnormal_sleep_pattern1.76506179
36MP0004142_abnormal_muscle_tone1.73723971
37MP0005645_abnormal_hypothalamus_physiol1.71894087
38MP0001188_hyperpigmentation1.70697905
39MP0002184_abnormal_innervation1.67335174
40MP0004924_abnormal_behavior1.66921595
41MP0005386_behavior/neurological_phenoty1.66921595
42MP0006292_abnormal_olfactory_placode1.66803037
43MP0002557_abnormal_social/conspecific_i1.65818981
44MP0009780_abnormal_chondrocyte_physiolo1.65650384
45MP0000647_abnormal_sebaceous_gland1.60394472
46MP0010386_abnormal_urinary_bladder1.52700905
47MP0002751_abnormal_autonomic_nervous1.52647543
48MP0002837_dystrophic_cardiac_calcinosis1.52516007
49MP0004811_abnormal_neuron_physiology1.51404487
50MP0002876_abnormal_thyroid_physiology1.51354508
51MP0008995_early_reproductive_senescence1.50094745
52MP0003787_abnormal_imprinting1.49902026
53MP0002938_white_spotting1.45850359
54MP0000566_synostosis1.45267189
55MP0003879_abnormal_hair_cell1.44471269
56MP0002909_abnormal_adrenal_gland1.43967860
57MP0008569_lethality_at_weaning1.43939813
58MP0003329_amyloid_beta_deposits1.40751728
59MP0002233_abnormal_nose_morphology1.33305340
60MP0002882_abnormal_neuron_morphology1.33201670
61MP0002066_abnormal_motor_capabilities/c1.30907792
62MP0000955_abnormal_spinal_cord1.27838021
63MP0002638_abnormal_pupillary_reflex1.27298267
64MP0001502_abnormal_circadian_rhythm1.24129096
65MP0000013_abnormal_adipose_tissue1.22561348
66MP0005253_abnormal_eye_physiology1.22060371
67MP0001293_anophthalmia1.20023109
68MP0003937_abnormal_limbs/digits/tail_de1.19863734
69MP0004147_increased_porphyrin_level1.19628871
70MP0005187_abnormal_penis_morphology1.18506101
71MP0003011_delayed_dark_adaptation1.18366197
72MP0000751_myopathy1.16746772
73MP0000049_abnormal_middle_ear1.15734043
74MP0008775_abnormal_heart_ventricle1.15144392
75MP0002127_abnormal_cardiovascular_syste1.13297151
76MP0003119_abnormal_digestive_system1.12752639
77MP0005551_abnormal_eye_electrophysiolog1.11056029
78MP0008875_abnormal_xenobiotic_pharmacok1.09180493
79MP0008058_abnormal_DNA_repair1.08010531
80MP0003183_abnormal_peptide_metabolism1.07095426
81MP0005195_abnormal_posterior_eye1.05426193
82MP0010030_abnormal_orbit_morphology1.03281700
83MP0000631_abnormal_neuroendocrine_gland1.01092850
84MP0003283_abnormal_digestive_organ0.99929229
85MP0005248_abnormal_Harderian_gland0.98889278
86MP0004858_abnormal_nervous_system0.98341553
87MP0002282_abnormal_trachea_morphology0.98188243
88MP0003646_muscle_fatigue0.97961556
89MP0000372_irregular_coat_pigmentation0.96905034
90MP0003633_abnormal_nervous_system0.96129085
91MP0003861_abnormal_nervous_system0.95469131
92MP0002152_abnormal_brain_morphology0.94932997
93MP0002229_neurodegeneration0.94901040
94MP0003938_abnormal_ear_development0.94346146
95MP0001963_abnormal_hearing_physiology0.94047985
96MP0003634_abnormal_glial_cell0.93476219
97MP0003186_abnormal_redox_activity0.92579790
98MP0003755_abnormal_palate_morphology0.91877231
99MP0009379_abnormal_foot_pigmentation0.90875514
100MP0003806_abnormal_nucleotide_metabolis0.89873421
101MP0003195_calcinosis0.89121211
102MP0009697_abnormal_copulation0.88146262
103MP0002234_abnormal_pharynx_morphology0.87491414
104MP0004885_abnormal_endolymph0.87357574
105MP0004043_abnormal_pH_regulation0.87252796
106MP0001664_abnormal_digestion0.85954940
107MP0002752_abnormal_somatic_nervous0.84746222
108MP0006035_abnormal_mitochondrial_morpho0.84523108
109MP0003631_nervous_system_phenotype0.84173668
110MP0008877_abnormal_DNA_methylation0.82863636
111MP0004742_abnormal_vestibular_system0.82395551
112MP0005084_abnormal_gallbladder_morpholo0.82156217
113MP0002069_abnormal_eating/drinking_beha0.81400448
114MP0008932_abnormal_embryonic_tissue0.81101029
115MP0001986_abnormal_taste_sensitivity0.80728357
116MP0004085_abnormal_heartbeat0.80137488
117MP0004215_abnormal_myocardial_fiber0.79802759
118MP0005499_abnormal_olfactory_system0.78875137
119MP0005394_taste/olfaction_phenotype0.78875137
120MP0002163_abnormal_gland_morphology0.78632301
121MP0003698_abnormal_male_reproductive0.78433396
122MP0005171_absent_coat_pigmentation0.78204051
123MP0000920_abnormal_myelination0.77981414
124MP0003718_maternal_effect0.77206760
125MP0005535_abnormal_body_temperature0.75760761
126MP0004145_abnormal_muscle_electrophysio0.75603723
127MP0004484_altered_response_of0.73253245
128MP0000026_abnormal_inner_ear0.71369085
129MP0005379_endocrine/exocrine_gland_phen0.71051180
130MP0002090_abnormal_vision0.70377021
131MP0000681_abnormal_thyroid_gland0.69474026
132MP0008872_abnormal_physiological_respon0.68603926
133MP0001177_atelectasis0.68548833
134MP0006036_abnormal_mitochondrial_physio0.67806438
135MP0004036_abnormal_muscle_relaxation0.64863325
136MP0001485_abnormal_pinna_reflex0.64496795
137MP0002653_abnormal_ependyma_morphology0.64479498
138MP0005409_darkened_coat_color0.63963193
139MP0004233_abnormal_muscle_weight0.63423578
140MP0006072_abnormal_retinal_apoptosis0.63292236
141MP0008789_abnormal_olfactory_epithelium0.63201327

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.16386084
2Acute necrotizing encephalopathy (HP:0006965)5.05137153
3Abnormal mitochondria in muscle tissue (HP:0008316)4.73923923
4Esophageal atresia (HP:0002032)4.73362071
5Myokymia (HP:0002411)4.63646124
6Progressive macrocephaly (HP:0004481)4.44281210
7Mitochondrial inheritance (HP:0001427)4.13767387
8Epileptic encephalopathy (HP:0200134)4.13062832
9Acute encephalopathy (HP:0006846)3.96543208
10Atonic seizures (HP:0010819)3.84944541
11Pheochromocytoma (HP:0002666)3.75157147
12Abnormality of midbrain morphology (HP:0002418)3.69338790
13Molar tooth sign on MRI (HP:0002419)3.69338790
14Gastrointestinal atresia (HP:0002589)3.61508989
15Abnormality of the aortic arch (HP:0012303)3.60635087
16Hepatocellular necrosis (HP:0001404)3.57780069
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.57009150
18Absent/shortened dynein arms (HP:0200106)3.57009150
19Neuroendocrine neoplasm (HP:0100634)3.56325714
20Gait imbalance (HP:0002141)3.52858005
21True hermaphroditism (HP:0010459)3.51727295
22Medial flaring of the eyebrow (HP:0010747)3.47797016
23Focal seizures (HP:0007359)3.42429219
24Increased CSF lactate (HP:0002490)3.41621114
25Visual hallucinations (HP:0002367)3.38019731
26Hyperventilation (HP:0002883)3.33589430
27Nephronophthisis (HP:0000090)3.33580457
28Pancreatic cysts (HP:0001737)3.22119832
29Limb dystonia (HP:0002451)3.20362198
30Polyphagia (HP:0002591)3.17268529
31Progressive cerebellar ataxia (HP:0002073)3.16832230
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14091779
33Abnormality of glycolysis (HP:0004366)3.12368645
34Increased serum pyruvate (HP:0003542)3.12368645
35Absence seizures (HP:0002121)3.10895570
36Congenital primary aphakia (HP:0007707)3.09849883
37Abnormality of the labia minora (HP:0012880)3.06093042
38Nephrogenic diabetes insipidus (HP:0009806)2.97212786
39Poor suck (HP:0002033)2.94686614
40Abnormal respiratory motile cilium physiology (HP:0012261)2.91224054
41Abnormal respiratory motile cilium morphology (HP:0005938)2.86417272
42Abnormal respiratory epithelium morphology (HP:0012253)2.86417272
43Abnormal ciliary motility (HP:0012262)2.85927276
44Aplasia cutis congenita (HP:0001057)2.81610512
45Febrile seizures (HP:0002373)2.78381855
46Hepatic necrosis (HP:0002605)2.78314074
47Dialeptic seizures (HP:0011146)2.75405220
48Optic disc pallor (HP:0000543)2.68420567
49Colon cancer (HP:0003003)2.64967689
50Abnormal hair whorl (HP:0010721)2.62588829
51Chronic hepatic failure (HP:0100626)2.61734393
52Abnormal eating behavior (HP:0100738)2.60034296
53Leukodystrophy (HP:0002415)2.58933502
54Generalized tonic-clonic seizures (HP:0002069)2.58528276
55Progressive inability to walk (HP:0002505)2.52651997
56Anxiety (HP:0000739)2.51754434
57Broad-based gait (HP:0002136)2.50749457
58Mutism (HP:0002300)2.49552166
59Abnormality of the renal medulla (HP:0100957)2.48014596
60Vaginal atresia (HP:0000148)2.43004225
61Respiratory failure (HP:0002878)2.42633178
62Genital tract atresia (HP:0001827)2.40236184
63Rhinitis (HP:0012384)2.40145198
64Retinal dysplasia (HP:0007973)2.37217396
65Ankle clonus (HP:0011448)2.35774383
66Septo-optic dysplasia (HP:0100842)2.35309270
67Optic nerve hypoplasia (HP:0000609)2.34449004
68Lipid accumulation in hepatocytes (HP:0006561)2.33601897
69Exercise intolerance (HP:0003546)2.29620803
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.26719883
71Lactic acidosis (HP:0003128)2.25083529
72Sclerocornea (HP:0000647)2.24244650
73Hypothermia (HP:0002045)2.22782536
74Occipital encephalocele (HP:0002085)2.20463185
75Lissencephaly (HP:0001339)2.18848698
76Specific learning disability (HP:0001328)2.16512461
77Inability to walk (HP:0002540)2.16003403
78Amblyopia (HP:0000646)2.15921006
79Epileptiform EEG discharges (HP:0011182)2.15754790
80Cerebral edema (HP:0002181)2.13654586
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11042896
82Agitation (HP:0000713)2.10667127
83Failure to thrive in infancy (HP:0001531)2.09985919
84X-linked dominant inheritance (HP:0001423)2.08265575
85Focal dystonia (HP:0004373)2.07351660
86Poor coordination (HP:0002370)2.06844121
87Neoplasm of the peripheral nervous system (HP:0100007)2.06032308
88Depression (HP:0000716)2.03714065
89Postaxial hand polydactyly (HP:0001162)2.01523966
90EEG with generalized epileptiform discharges (HP:0011198)2.01428014
91Delusions (HP:0000746)2.01399788
92Gaze-evoked nystagmus (HP:0000640)2.01346746
93Oligomenorrhea (HP:0000876)1.99828240
94Increased hepatocellular lipid droplets (HP:0006565)1.99633588
95Stenosis of the external auditory canal (HP:0000402)1.99353572
96Renal Fanconi syndrome (HP:0001994)1.98588176
97Fetal akinesia sequence (HP:0001989)1.98552427
98Supranuclear gaze palsy (HP:0000605)1.98323488
99Aplasia/Hypoplasia of the lens (HP:0008063)1.98250913
100Hyperglycinemia (HP:0002154)1.96725981
101Neurofibrillary tangles (HP:0002185)1.95623100
102Akinesia (HP:0002304)1.95611477
103Torticollis (HP:0000473)1.95129963
104Anencephaly (HP:0002323)1.92587116
105Hypsarrhythmia (HP:0002521)1.90647664
106Megalencephaly (HP:0001355)1.90515822
107Split foot (HP:0001839)1.89928956
108Postaxial foot polydactyly (HP:0001830)1.89858187
109Craniofacial dystonia (HP:0012179)1.89425801
110Infertility (HP:0000789)1.88661042
111Narrow forehead (HP:0000341)1.88650718
112Poor eye contact (HP:0000817)1.87854891
113CNS demyelination (HP:0007305)1.87211543
114Truncal ataxia (HP:0002078)1.87044941
115Methylmalonic acidemia (HP:0002912)1.86623783
116Esotropia (HP:0000565)1.86084448
117Cystic liver disease (HP:0006706)1.85817715
118Male pseudohermaphroditism (HP:0000037)1.85571672
119Increased serum lactate (HP:0002151)1.85496733
120Chorioretinal coloboma (HP:0000567)1.85222337
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84827972
122Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84827972
123Absent septum pellucidum (HP:0001331)1.83299829
124Broad foot (HP:0001769)1.81862657
125Anophthalmia (HP:0000528)1.80870198
126Oligodactyly (hands) (HP:0001180)1.80835056
1273-Methylglutaconic aciduria (HP:0003535)1.78358161
128Hypoplastic pelvis (HP:0008839)1.78297120
129Hypoplasia of the brainstem (HP:0002365)1.78193976
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78193976
131Poor speech (HP:0002465)1.77997947
132Scrotal hypoplasia (HP:0000046)1.77274157
133Pancreatic fibrosis (HP:0100732)1.76876545
134Sleep apnea (HP:0010535)1.76775302
135Action tremor (HP:0002345)1.75587387
136Emotional lability (HP:0000712)1.75054619
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74922971
138Preaxial hand polydactyly (HP:0001177)1.74817975
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.73516481
140Tubulointerstitial nephritis (HP:0001970)1.70809574
141Duodenal stenosis (HP:0100867)1.70668190
142Small intestinal stenosis (HP:0012848)1.70668190
143Intestinal atresia (HP:0011100)1.68150645
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.66161266
145Patellar aplasia (HP:0006443)1.65318466
146Aganglionic megacolon (HP:0002251)1.64148918
147Pterygium (HP:0001059)1.62334970
148Abnormality of renal resorption (HP:0011038)1.61125556
149Supernumerary spleens (HP:0009799)1.59942821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK28.02412598
2TLK14.33088843
3MAP2K64.21700118
4MAP4K24.17611803
5CASK3.97724250
6MAP3K123.92601882
7MARK13.38591770
8MAP2K73.08206555
9MAP3K52.70128705
10NTRK32.69803982
11MAP3K42.50774010
12CDK192.44045500
13MINK12.29068579
14EPHA42.22074206
15ARAF2.20452641
16PLK22.12009812
17MAP3K91.96080214
18TRIM281.87194622
19PDK31.86112702
20PDK41.86112702
21TNIK1.82929444
22DAPK21.80590295
23SIK21.79790061
24NME11.77038527
25MAPK131.75605988
26BCR1.69108708
27OXSR11.67563646
28DAPK11.58167534
29PRPF4B1.46339058
30SRPK11.46270918
31NTRK21.43505565
32LIMK11.42626249
33CCNB11.42028522
34MAP2K41.41567367
35TESK11.35874402
36SIK31.35661777
37VRK21.33082633
38STK161.31460468
39FRK1.28100808
40GRK51.26241984
41STK391.25065503
42DYRK21.23314422
43CSNK1G11.21869578
44PDK21.21476111
45PRKCG1.19008963
46ERBB31.18945647
47BMPR1B1.16812933
48PHKG11.16092981
49PHKG21.16092981
50CDK51.15303527
51MYLK1.14584115
52BUB11.13011244
53CAMK2A1.08744462
54AKT31.05446482
55CDK141.04562375
56UHMK11.03301558
57BRAF1.02896301
58BMPR21.02585598
59PNCK1.02486549
60WNK41.01051716
61NUAK11.00773553
62KSR10.98955743
63SGK4940.98497568
64SGK2230.98497568
65ZAK0.98264888
66INSRR0.97967675
67CDK180.97912809
68WNK30.97911927
69CAMK2B0.97027454
70PAK60.95604082
71PTK2B0.93431781
72CAMKK20.92753161
73PRKD30.91369435
74CDK150.88068388
75MUSK0.87754984
76PLK30.85785407
77ADRBK20.81446833
78MKNK10.81146076
79DYRK30.81117834
80CSNK1G20.80320415
81MKNK20.80115302
82PRKCE0.79775908
83LMTK20.79506277
84BCKDK0.79170041
85CDK11A0.77828165
86NTRK10.77607018
87TTK0.76269715
88GRK10.75313343
89CAMK2D0.73221902
90MAP3K80.72744697
91PIK3CA0.70511818
92WEE10.70360816
93PINK10.68225445
94FGFR20.66551892
95CSNK1G30.65672878
96RIPK40.65234474
97CDC70.64647803
98SGK20.62250478
99CAMK2G0.60311407
100MAPKAPK50.59821452
101KSR20.59233321
102DAPK30.59116090
103ADRBK10.58060587
104PAK30.57895595
105EPHB20.56698477
106DYRK1A0.56540211
107GRK70.56280985
108CAMKK10.56225115
109PLK40.55867816
110MAPKAPK30.53955912
111MAPK150.53599090
112PIM20.50898825
113PLK10.50125577
114CDK80.49759567
115STK38L0.48240346
116LATS20.47012841
117FES0.45994307
118CAMK10.45664014
119TAF10.45028436
120PBK0.43560832
121ATR0.42239190
122EPHA30.41122920
123TSSK60.41108902
124NEK60.40857145
125MST40.40688026
126CSNK1A10.39434294
127PRKCZ0.37364537
128FER0.36891891
129VRK10.35762570
130PRKACA0.35575212
131NEK10.35423760
132ROCK20.34702505
133AURKA0.34698349
134PKN10.34485165
135RPS6KA40.33131751
136CHEK20.30708352
137CSNK1A1L0.29772459
138CSNK2A10.29770955
139PRKG10.29709404
140RAF10.29684828
141IRAK20.26197990
142TIE10.26191172
143PRKACB0.23835950
144CSNK1E0.23555954
145DYRK1B0.22462956
146ATM0.20271017

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.11012184
2Synaptic vesicle cycle_Homo sapiens_hsa047213.90749165
3Collecting duct acid secretion_Homo sapiens_hsa049663.46577072
4Parkinsons disease_Homo sapiens_hsa050123.37929871
5Nicotine addiction_Homo sapiens_hsa050333.20689784
6Alzheimers disease_Homo sapiens_hsa050102.68574725
7Vibrio cholerae infection_Homo sapiens_hsa051102.57205614
8Huntingtons disease_Homo sapiens_hsa050162.48274174
9GABAergic synapse_Homo sapiens_hsa047272.36319761
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30430960
11Olfactory transduction_Homo sapiens_hsa047402.25475698
12Circadian entrainment_Homo sapiens_hsa047132.08881231
13Morphine addiction_Homo sapiens_hsa050322.06303568
14RNA polymerase_Homo sapiens_hsa030202.04947695
15Cardiac muscle contraction_Homo sapiens_hsa042602.02954486
16Amphetamine addiction_Homo sapiens_hsa050311.94916604
17Dopaminergic synapse_Homo sapiens_hsa047281.83307140
18Long-term potentiation_Homo sapiens_hsa047201.82495348
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82400988
20Glutamatergic synapse_Homo sapiens_hsa047241.78972795
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78798587
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78108842
23Serotonergic synapse_Homo sapiens_hsa047261.70744097
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68402586
25Ribosome_Homo sapiens_hsa030101.64900480
26Basal transcription factors_Homo sapiens_hsa030221.62063603
27Proteasome_Homo sapiens_hsa030501.57805535
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.56644557
29Insulin secretion_Homo sapiens_hsa049111.53325534
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53237968
31Protein export_Homo sapiens_hsa030601.49432234
32Mismatch repair_Homo sapiens_hsa034301.48256861
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47567177
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47280572
35Homologous recombination_Homo sapiens_hsa034401.42787094
36Taste transduction_Homo sapiens_hsa047421.42526258
37Cholinergic synapse_Homo sapiens_hsa047251.38066797
38Fanconi anemia pathway_Homo sapiens_hsa034601.37029916
39Salivary secretion_Homo sapiens_hsa049701.31858540
40Cocaine addiction_Homo sapiens_hsa050301.31760032
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29063171
42Long-term depression_Homo sapiens_hsa047301.28104095
43Rheumatoid arthritis_Homo sapiens_hsa053231.25155610
44Renin secretion_Homo sapiens_hsa049241.23932685
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21218958
46Gastric acid secretion_Homo sapiens_hsa049711.20985947
47RNA degradation_Homo sapiens_hsa030181.19619898
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19070962
49Pyrimidine metabolism_Homo sapiens_hsa002401.18665508
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15588811
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14021276
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13702771
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11636156
54Calcium signaling pathway_Homo sapiens_hsa040201.09238862
55Phototransduction_Homo sapiens_hsa047441.08418661
56Phagosome_Homo sapiens_hsa041451.07271414
57Glutathione metabolism_Homo sapiens_hsa004801.02428770
58Nucleotide excision repair_Homo sapiens_hsa034201.02375409
59Spliceosome_Homo sapiens_hsa030401.00604216
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99544257
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.98234143
62Oxytocin signaling pathway_Homo sapiens_hsa049210.97968722
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95782953
64Pyruvate metabolism_Homo sapiens_hsa006200.94186534
65Axon guidance_Homo sapiens_hsa043600.91229328
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89288771
67Selenocompound metabolism_Homo sapiens_hsa004500.89267190
68Gap junction_Homo sapiens_hsa045400.89097791
69Peroxisome_Homo sapiens_hsa041460.88642296
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88525445
71DNA replication_Homo sapiens_hsa030300.86728121
72beta-Alanine metabolism_Homo sapiens_hsa004100.85216637
73RNA transport_Homo sapiens_hsa030130.85147627
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84207755
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83543738
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83460824
77Folate biosynthesis_Homo sapiens_hsa007900.82877237
78Basal cell carcinoma_Homo sapiens_hsa052170.77289142
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.76932930
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76116644
81Type I diabetes mellitus_Homo sapiens_hsa049400.74516772
82Non-homologous end-joining_Homo sapiens_hsa034500.73720313
83Chemical carcinogenesis_Homo sapiens_hsa052040.72298073
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71943533
85Sulfur metabolism_Homo sapiens_hsa009200.71788205
86cAMP signaling pathway_Homo sapiens_hsa040240.69075456
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.65801130
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65767984
89Oocyte meiosis_Homo sapiens_hsa041140.65707660
90Fatty acid elongation_Homo sapiens_hsa000620.64736716
91Sulfur relay system_Homo sapiens_hsa041220.64341346
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64329550
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64040567
94Butanoate metabolism_Homo sapiens_hsa006500.63609162
95GnRH signaling pathway_Homo sapiens_hsa049120.63407819
96Hedgehog signaling pathway_Homo sapiens_hsa043400.63324236
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62677340
98Base excision repair_Homo sapiens_hsa034100.62186570
99Tryptophan metabolism_Homo sapiens_hsa003800.60897903
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.60341200
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.60321212
102Nitrogen metabolism_Homo sapiens_hsa009100.59377845
103Retinol metabolism_Homo sapiens_hsa008300.59203781
104Melanogenesis_Homo sapiens_hsa049160.58193268
105Regulation of autophagy_Homo sapiens_hsa041400.56504301
106TGF-beta signaling pathway_Homo sapiens_hsa043500.55684832
107Hippo signaling pathway_Homo sapiens_hsa043900.55300526
108Caffeine metabolism_Homo sapiens_hsa002320.54584214
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52017479
110Linoleic acid metabolism_Homo sapiens_hsa005910.51942839
111ErbB signaling pathway_Homo sapiens_hsa040120.51534060
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49977310
113mRNA surveillance pathway_Homo sapiens_hsa030150.48774838
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47106913
115Estrogen signaling pathway_Homo sapiens_hsa049150.45009862
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44584647
117Alcoholism_Homo sapiens_hsa050340.44453086
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44097054
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43847391
120Fatty acid metabolism_Homo sapiens_hsa012120.43552783
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42788991
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40538631
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39654321
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38870381
125Pancreatic secretion_Homo sapiens_hsa049720.38691950
126Thyroid hormone synthesis_Homo sapiens_hsa049180.38148167
127Ras signaling pathway_Homo sapiens_hsa040140.37528515
128Glioma_Homo sapiens_hsa052140.36728986
129Dilated cardiomyopathy_Homo sapiens_hsa054140.35237769
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35170437
131Ether lipid metabolism_Homo sapiens_hsa005650.32743583
132N-Glycan biosynthesis_Homo sapiens_hsa005100.31457843
133Steroid biosynthesis_Homo sapiens_hsa001000.30014487
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27509968
135Endocytosis_Homo sapiens_hsa041440.26621327
136Glucagon signaling pathway_Homo sapiens_hsa049220.25452737
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24967390
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24002272
139MAPK signaling pathway_Homo sapiens_hsa040100.23478281
140Metabolic pathways_Homo sapiens_hsa011000.22982888
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21796681
142Propanoate metabolism_Homo sapiens_hsa006400.21215315
143Renal cell carcinoma_Homo sapiens_hsa052110.20459795
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.19806823
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19014504
146Lysosome_Homo sapiens_hsa041420.18079641
147Wnt signaling pathway_Homo sapiens_hsa043100.16447159
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16190623
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15992421
150Prion diseases_Homo sapiens_hsa050200.15328070
151Purine metabolism_Homo sapiens_hsa002300.15210404
152Circadian rhythm_Homo sapiens_hsa047100.14986673
153Type II diabetes mellitus_Homo sapiens_hsa049300.14921858

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