HSD11B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)7.62514929
2exogenous drug catabolic process (GO:0042738)7.56533108
3epoxygenase P450 pathway (GO:0019373)7.41949186
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.29896268
5L-phenylalanine catabolic process (GO:0006559)7.29896268
6L-phenylalanine metabolic process (GO:0006558)6.96585411
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.96585411
8aromatic amino acid family catabolic process (GO:0009074)6.60991778
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.29174425
10tryptophan catabolic process (GO:0006569)5.99556691
11indole-containing compound catabolic process (GO:0042436)5.99556691
12indolalkylamine catabolic process (GO:0046218)5.99556691
13kynurenine metabolic process (GO:0070189)5.84566930
14bile acid biosynthetic process (GO:0006699)5.79108330
15alpha-linolenic acid metabolic process (GO:0036109)5.65380487
16tryptophan metabolic process (GO:0006568)5.63785097
17glyoxylate metabolic process (GO:0046487)5.59507490
18high-density lipoprotein particle remodeling (GO:0034375)5.43734838
19urea cycle (GO:0000050)5.41004398
20urea metabolic process (GO:0019627)5.41004398
21negative regulation of fibrinolysis (GO:0051918)5.40320526
22sulfur amino acid catabolic process (GO:0000098)5.33999948
23cysteine metabolic process (GO:0006534)5.31236183
24complement activation, alternative pathway (GO:0006957)5.31039384
25regulation of protein activation cascade (GO:2000257)5.27294110
26protein carboxylation (GO:0018214)5.21659802
27peptidyl-glutamic acid carboxylation (GO:0017187)5.21659802
28regulation of fibrinolysis (GO:0051917)5.17078169
29drug metabolic process (GO:0017144)5.05941356
30serine family amino acid catabolic process (GO:0009071)5.01869101
31nitrogen cycle metabolic process (GO:0071941)4.98011352
32bile acid metabolic process (GO:0008206)4.97395521
33regulation of complement activation (GO:0030449)4.96249305
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89243231
35ethanol metabolic process (GO:0006067)4.83895107
36oxidative demethylation (GO:0070989)4.82776862
37androgen biosynthetic process (GO:0006702)4.81650036
38homocysteine metabolic process (GO:0050667)4.81512790
39reverse cholesterol transport (GO:0043691)4.78166037
40aromatic amino acid family metabolic process (GO:0009072)4.77147869
41regulation of cholesterol esterification (GO:0010872)4.76524654
42regulation of triglyceride catabolic process (GO:0010896)4.76086096
43protein-lipid complex remodeling (GO:0034368)4.71136945
44macromolecular complex remodeling (GO:0034367)4.71136945
45plasma lipoprotein particle remodeling (GO:0034369)4.71136945
46lysine catabolic process (GO:0006554)4.63509436
47lysine metabolic process (GO:0006553)4.63509436
48amino-acid betaine metabolic process (GO:0006577)4.59659439
49tyrosine metabolic process (GO:0006570)4.59299108
50alpha-amino acid catabolic process (GO:1901606)4.55278066
51triglyceride homeostasis (GO:0070328)4.49869279
52acylglycerol homeostasis (GO:0055090)4.49869279
53phospholipid efflux (GO:0033700)4.47826113
54negative regulation of sterol transport (GO:0032372)4.45743215
55negative regulation of cholesterol transport (GO:0032375)4.45743215
56regulation of plasminogen activation (GO:0010755)4.45304046
57cellular ketone body metabolic process (GO:0046950)4.42029412
58plasma lipoprotein particle clearance (GO:0034381)4.32566574
59bile acid and bile salt transport (GO:0015721)4.31281621
60cellular glucuronidation (GO:0052695)4.28404244
61indolalkylamine metabolic process (GO:0006586)4.22223368
62cellular amino acid catabolic process (GO:0009063)4.21859745
63acute-phase response (GO:0006953)4.20800809
64coenzyme catabolic process (GO:0009109)4.20015181
65glycine metabolic process (GO:0006544)4.19028535
66amine catabolic process (GO:0009310)4.17855859
67cellular biogenic amine catabolic process (GO:0042402)4.17855859
68ethanol oxidation (GO:0006069)4.15940406
69imidazole-containing compound metabolic process (GO:0052803)4.14744865
70glutamate metabolic process (GO:0006536)4.14735635
71low-density lipoprotein particle remodeling (GO:0034374)4.11062980
72cholesterol efflux (GO:0033344)4.08525663
73negative regulation of blood coagulation (GO:0030195)4.07576404
74negative regulation of hemostasis (GO:1900047)4.07576404
75cellular modified amino acid catabolic process (GO:0042219)4.06799406
76serine family amino acid metabolic process (GO:0009069)4.05244665
77benzene-containing compound metabolic process (GO:0042537)4.04937916
78drug catabolic process (GO:0042737)4.01321922
79phenylpropanoid metabolic process (GO:0009698)3.97917977
80dicarboxylic acid biosynthetic process (GO:0043650)3.95177877
81plasma lipoprotein particle assembly (GO:0034377)3.93274724
82fibrinolysis (GO:0042730)3.90182300
83cellular response to cadmium ion (GO:0071276)3.90093506
84positive regulation of triglyceride metabolic process (GO:0090208)3.89184547
85androgen metabolic process (GO:0008209)3.88095782
86serine family amino acid biosynthetic process (GO:0009070)3.86027382
87S-adenosylmethionine metabolic process (GO:0046500)3.84424329
88arginine metabolic process (GO:0006525)3.84267668
89low-density lipoprotein particle clearance (GO:0034383)3.83590719
90regulation of humoral immune response (GO:0002920)3.82992798
91adhesion of symbiont to host (GO:0044406)3.82919569
92hormone catabolic process (GO:0042447)3.82441482
93ketone body metabolic process (GO:1902224)3.81716931
94aldehyde catabolic process (GO:0046185)3.81653398
95uronic acid metabolic process (GO:0006063)3.79961818
96glucuronate metabolic process (GO:0019585)3.79961818
97short-chain fatty acid metabolic process (GO:0046459)3.76815011
98negative regulation of coagulation (GO:0050819)3.75541604
99positive regulation of lipid catabolic process (GO:0050996)3.74838009
100complement activation, classical pathway (GO:0006958)3.74128990
101complement activation (GO:0006956)3.73576186
102negative regulation of wound healing (GO:0061045)3.72312039
103cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.72139013
104carboxylic acid catabolic process (GO:0046395)3.72038636
105organic acid catabolic process (GO:0016054)3.72038636
106blood coagulation, intrinsic pathway (GO:0007597)3.71994423
107hemoglobin metabolic process (GO:0020027)3.70203524
108positive regulation of triglyceride lipase activity (GO:0061365)3.70085535
109positive regulation of lipoprotein lipase activity (GO:0051006)3.70085535
110phospholipid homeostasis (GO:0055091)3.69688383
111very-low-density lipoprotein particle assembly (GO:0034379)3.68432320
112negative regulation of lipase activity (GO:0060192)3.68423487
113protein activation cascade (GO:0072376)3.67672532
114amyloid precursor protein catabolic process (GO:0042987)3.67595632
115acetyl-CoA metabolic process (GO:0006084)3.65850336
116cholesterol homeostasis (GO:0042632)3.65149690
117steroid catabolic process (GO:0006706)3.63588205
118plasma lipoprotein particle organization (GO:0071827)3.61589465
119cytolysis (GO:0019835)3.61369510
120negative regulation of protein activation cascade (GO:2000258)3.61340479
121opsonization (GO:0008228)3.59797513
122regulation of cholesterol homeostasis (GO:2000188)3.59661725
123sterol homeostasis (GO:0055092)3.59435570
124regulation of bile acid biosynthetic process (GO:0070857)3.59163099
125cofactor catabolic process (GO:0051187)3.59155659
126sodium-independent organic anion transport (GO:0043252)3.56210871
127protein-lipid complex assembly (GO:0065005)3.52988428
128killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.43222237
129disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.43222237
130negative regulation of complement activation (GO:0045916)3.38338668
131positive regulation of hemostasis (GO:1900048)3.37982765
132positive regulation of blood coagulation (GO:0030194)3.37982765
133sterol catabolic process (GO:0016127)3.37933444
134cholesterol catabolic process (GO:0006707)3.37933444
135acute inflammatory response (GO:0002526)3.34882743
136regulation of triglyceride metabolic process (GO:0090207)3.34422851
137intestinal cholesterol absorption (GO:0030299)3.31315768
138drug transmembrane transport (GO:0006855)3.27877136
139alkaloid metabolic process (GO:0009820)3.25516270
140positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.24608219
141xenobiotic catabolic process (GO:0042178)3.20766708
142regulation of acute inflammatory response (GO:0002673)3.19506307
143positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.19056934
144response to mercury ion (GO:0046689)3.17832114
145detection of molecule of bacterial origin (GO:0032490)3.15537496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.17921691
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.99771687
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.74030426
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.36555660
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.13528984
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.99580581
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89184648
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95629004
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83627868
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.06235317
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11405125
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5618554
13* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.98171427
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88353554
15CLOCK_20551151_ChIP-Seq_293T_Human1.79811271
16GATA1_22025678_ChIP-Seq_K562_Human1.64168994
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.57320564
18HTT_18923047_ChIP-ChIP_STHdh_Human1.49564878
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42228798
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.41339885
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39531364
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39439995
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.35349555
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28659552
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22101540
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.14506540
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14381210
28* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11592180
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08052893
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06009477
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05406247
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01604769
33CJUN_26792858_Chip-Seq_BT549_Human0.98858093
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97731074
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97680944
36JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97659181
37PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97144542
38EP300_21415370_ChIP-Seq_HL-1_Mouse0.95243315
39ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94639657
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93994493
41CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93129881
42SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90860943
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89703561
44PIAS1_25552417_ChIP-Seq_VCAP_Human0.88985399
45VDR_24787735_ChIP-Seq_THP-1_Human0.87901921
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86767540
47* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86016498
48TP53_18474530_ChIP-ChIP_U2OS_Human0.85813011
49TBX20_22328084_ChIP-Seq_HEART_Mouse0.85528260
50TBX20_22080862_ChIP-Seq_HEART_Mouse0.85528260
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85360324
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85339754
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84686877
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83758262
55ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82579251
56AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81760324
57SMAD_19615063_ChIP-ChIP_OVARY_Human0.81116686
58NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80542195
59ESR2_21235772_ChIP-Seq_MCF-7_Human0.80305881
60* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78768686
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78742853
62GATA4_25053715_ChIP-Seq_YYC3_Human0.78613031
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78566915
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76686670
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76109411
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75531834
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75414482
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75414482
69IRF8_27001747_Chip-Seq_BMDM_Mouse0.72781317
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72386144
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71360867
72KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71000136
73* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69282501
74SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68877466
75* RARA_24833708_ChIP-Seq_LIVER_Mouse0.66852416
76BP1_19119308_ChIP-ChIP_Hs578T_Human0.66223143
77BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65293782
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64779221
79SOX9_24532713_ChIP-Seq_HFSC_Mouse0.64252706
80RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63772890
81LXR_22292898_ChIP-Seq_THP-1_Human0.63387355
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.62734205
83CEBPB_22108803_ChIP-Seq_LS180_Human0.62595544
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62335661
85TP63_23658742_ChIP-Seq_EP156T_Human0.61001394
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.60452463
87TP53_16413492_ChIP-PET_HCT116_Human0.59345797
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57254384
89* RARB_24833708_ChIP-Seq_LIVER_Mouse0.57231852
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57141560
91EGR1_19032775_ChIP-ChIP_M12_Human0.55236992
92MYC_19915707_ChIP-ChIP_AK7_Human0.55211207
93ZNF263_19887448_ChIP-Seq_K562_Human0.54799164
94POU5F1_16518401_ChIP-PET_MESCs_Mouse0.54594520
95GF1_26923725_Chip-Seq_HPCs_Mouse0.54309411
96* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54047860
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.53846583
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.53783005
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.53678158
100PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53356631
101STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.53065118
102GATA1_19941826_ChIP-Seq_K562_Human0.51742892
103BCAT_22108803_ChIP-Seq_LS180_Human0.51696022
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.51207247
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50890626
106* AR_20517297_ChIP-Seq_VCAP_Human0.50877972
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.50076476
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50061110
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.49399658
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48963175
111GATA2_19941826_ChIP-Seq_K562_Human0.48932395
112STAT1_17558387_ChIP-Seq_HELA_Human0.48694387
113CBP_21632823_ChIP-Seq_H3396_Human0.46686931
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.46393988
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.45672303
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45589882
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.45520363
118* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45341324
119P53_21459846_ChIP-Seq_SAOS-2_Human0.45138624
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44762485
121* ESET_19884257_ChIP-Seq_ESCs_Mouse0.43610334
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42803846
123TAF2_19829295_ChIP-Seq_ESCs_Human0.42437499
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41853558
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.41678673
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40927049
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39469002
128SOX2_20726797_ChIP-Seq_SW620_Human0.38628007
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.38546081
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.38289611
131* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38095854
132* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.37889108
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.37674386
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37639986
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.37150946
136CDX2_22108803_ChIP-Seq_LS180_Human0.36645572
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35841891
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.35446738
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.35390723
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.35357218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22465563
2MP0005360_urolithiasis7.47134244
3MP0005085_abnormal_gallbladder_physiolo6.17263960
4MP0005365_abnormal_bile_salt5.99218243
5MP0008875_abnormal_xenobiotic_pharmacok5.21737220
6MP0003806_abnormal_nucleotide_metabolis4.18189590
7MP0008004_abnormal_stomach_pH3.90480589
8MP0003252_abnormal_bile_duct3.81285828
9* MP0010329_abnormal_lipoprotein_level3.49506359
10MP0009840_abnormal_foam_cell3.24490303
11MP0005083_abnormal_biliary_tract2.93290110
12MP0005332_abnormal_amino_acid2.84087600
13MP0003195_calcinosis2.63406099
14MP0001666_abnormal_nutrient_absorption2.48041344
15MP0003191_abnormal_cellular_cholesterol2.33874737
16MP0004019_abnormal_vitamin_homeostasis2.16873445
17* MP0000609_abnormal_liver_physiology2.12854920
18* MP0002118_abnormal_lipid_homeostasis2.08939725
19MP0002138_abnormal_hepatobiliary_system2.08280424
20MP0005319_abnormal_enzyme/_coenzyme1.81539061
21MP0003868_abnormal_feces_composition1.78054651
22MP0001764_abnormal_homeostasis1.65341635
23MP0003279_aneurysm1.54984044
24MP0003300_gastrointestinal_ulcer1.54474079
25* MP0005584_abnormal_enzyme/coenzyme_acti1.54144171
26MP0008438_abnormal_cutaneous_collagen1.52522840
27MP0009697_abnormal_copulation1.52167258
28MP0002332_abnormal_exercise_endurance1.49398525
29MP0005451_abnormal_body_composition1.37761357
30MP0003011_delayed_dark_adaptation1.32801353
31MP0009643_abnormal_urine_homeostasis1.32524532
32MP0003186_abnormal_redox_activity1.32231581
33MP0005023_abnormal_wound_healing1.22830090
34MP0000604_amyloidosis1.22266512
35MP0003656_abnormal_erythrocyte_physiolo1.17710172
36MP0002254_reproductive_system_inflammat1.16868642
37MP0005647_abnormal_sex_gland1.16117997
38MP0009764_decreased_sensitivity_to1.15741881
39MP0003705_abnormal_hypodermis_morpholog1.15665894
40MP0000598_abnormal_liver_morphology1.13942440
41MP0009763_increased_sensitivity_to1.04661147
42MP0004272_abnormal_basement_membrane1.02895062
43MP0010368_abnormal_lymphatic_system0.98760278
44MP0005636_abnormal_mineral_homeostasis0.97913941
45MP0005670_abnormal_white_adipose0.97348037
46MP0008469_abnormal_protein_level0.94779861
47MP0002876_abnormal_thyroid_physiology0.88077890
48* MP0009642_abnormal_blood_homeostasis0.87285726
49MP0001661_extended_life_span0.85546706
50MP0004130_abnormal_muscle_cell0.83027315
51MP0002971_abnormal_brown_adipose0.82400239
52MP0006036_abnormal_mitochondrial_physio0.81317265
53MP0005376_homeostasis/metabolism_phenot0.80340568
54MP0004233_abnormal_muscle_weight0.78726652
55MP0003329_amyloid_beta_deposits0.78724841
56MP0003690_abnormal_glial_cell0.77845231
57MP0005375_adipose_tissue_phenotype0.77593622
58MP0002282_abnormal_trachea_morphology0.77271507
59MP0009765_abnormal_xenobiotic_induced0.74795967
60MP0005408_hypopigmentation0.74098154
61MP0002295_abnormal_pulmonary_circulatio0.73777100
62* MP0002078_abnormal_glucose_homeostasis0.73722366
63MP0004510_myositis0.73446513
64MP0001851_eye_inflammation0.71885501
65MP0001915_intracranial_hemorrhage0.71639928
66MP0002998_abnormal_bone_remodeling0.71463691
67MP0005084_abnormal_gallbladder_morpholo0.71331161
68MP0005535_abnormal_body_temperature0.70182155
69MP0002896_abnormal_bone_mineralization0.69852112
70MP0008775_abnormal_heart_ventricle0.69412464
71MP0005275_abnormal_skin_tensile0.69182825
72MP0003724_increased_susceptibility_to0.68638427
73MP0002909_abnormal_adrenal_gland0.66828713
74* MP0005334_abnormal_fat_pad0.65054482
75MP0001756_abnormal_urination0.64995379
76MP0005187_abnormal_penis_morphology0.62415868
77MP0005220_abnormal_exocrine_pancreas0.61479680
78MP0005464_abnormal_platelet_physiology0.60046299
79MP0002837_dystrophic_cardiac_calcinosis0.59732237
80MP0005266_abnormal_metabolism0.58944146
81MP0003091_abnormal_cell_migration0.58939973
82MP0002877_abnormal_melanocyte_morpholog0.58886107
83MP0003566_abnormal_cell_adhesion0.58690218
84MP0000343_altered_response_to0.57005160
85MP0009785_altered_susceptibility_to0.56350159
86MP0002136_abnormal_kidney_physiology0.55760522
87MP0002933_joint_inflammation0.55364356
88MP0005448_abnormal_energy_balance0.54067461
89MP0003436_decreased_susceptibility_to0.52589128
90MP0004782_abnormal_surfactant_physiolog0.52203409
91MP0001533_abnormal_skeleton_physiology0.52094237
92MP0003828_pulmonary_edema0.52073541
93MP0003075_altered_response_to0.51840039
94MP0003303_peritoneal_inflammation0.51233029
95MP0006035_abnormal_mitochondrial_morpho0.50814947
96MP0009053_abnormal_anal_canal0.50359398
97MP0008874_decreased_physiological_sensi0.49902893
98MP0003638_abnormal_response/metabolism_0.49863056
99MP0006082_CNS_inflammation0.49764581
100MP0005666_abnormal_adipose_tissue0.48770004
101MP0005395_other_phenotype0.45483551
102MP0005166_decreased_susceptibility_to0.44900346
103MP0000249_abnormal_blood_vessel0.44569020
104* MP0000639_abnormal_adrenal_gland0.44549926
105MP0002928_abnormal_bile_duct0.44125281
106MP0004883_abnormal_blood_vessel0.42908511
107MP0008873_increased_physiological_sensi0.42143149
108MP0001853_heart_inflammation0.41831000
109MP0002822_catalepsy0.40969626
110MP0009115_abnormal_fat_cell0.40527533
111* MP0003953_abnormal_hormone_level0.39138169
112MP0009384_cardiac_valve_regurgitation0.38866059
113MP0001845_abnormal_inflammatory_respons0.38264503
114MP0005167_abnormal_blood-brain_barrier0.38101702
115MP0005058_abnormal_lysosome_morphology0.37959621
116MP0005164_abnormal_response_to0.37549825
117MP0002168_other_aberrant_phenotype0.37455431
118MP0000230_abnormal_systemic_arterial0.36383718
119MP0001881_abnormal_mammary_gland0.36257494
120MP0002132_abnormal_respiratory_system0.35209572
121MP0001243_abnormal_dermal_layer0.34686290
122MP0002970_abnormal_white_adipose0.34280086
123MP0008872_abnormal_physiological_respon0.33532018
124MP0004381_abnormal_hair_follicle0.31629197
125MP0002796_impaired_skin_barrier0.31321182
126MP0003718_maternal_effect0.31148797
127MP0005248_abnormal_Harderian_gland0.30697793
128MP0005595_abnormal_vascular_smooth0.29739347
129MP0002060_abnormal_skin_morphology0.29158937

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.31413917
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.12225467
3Intrahepatic cholestasis (HP:0001406)7.04544272
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.36911722
5Prolonged partial thromboplastin time (HP:0003645)6.31414338
6Hypobetalipoproteinemia (HP:0003563)6.19698869
7Xanthomatosis (HP:0000991)6.19311636
8Hyperlipoproteinemia (HP:0010980)5.67095098
9Complement deficiency (HP:0004431)5.30418189
10Joint hemorrhage (HP:0005261)4.71966872
11Hypolipoproteinemia (HP:0010981)4.70866262
12Hyperammonemia (HP:0001987)4.58501725
13Abnormality of the common coagulation pathway (HP:0010990)4.34665312
14Hyperglycinemia (HP:0002154)4.33949759
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33297522
16Epidermoid cyst (HP:0200040)4.33063151
17Ketosis (HP:0001946)4.27262116
18Hypoalphalipoproteinemia (HP:0003233)4.18550517
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.18501317
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18320744
21Abnormality of methionine metabolism (HP:0010901)4.15153472
22Hyperglycinuria (HP:0003108)4.08641840
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07133269
24Fat malabsorption (HP:0002630)3.98797646
25Abnormality of glycine metabolism (HP:0010895)3.98795651
26Abnormality of serine family amino acid metabolism (HP:0010894)3.98795651
27Abnormality of complement system (HP:0005339)3.83396350
28Hypoglycemic coma (HP:0001325)3.82855635
29Abnormality of the intrinsic pathway (HP:0010989)3.66007937
30Abnormality of pyrimidine metabolism (HP:0004353)3.59676234
31Conjugated hyperbilirubinemia (HP:0002908)3.56970880
32Hypercholesterolemia (HP:0003124)3.55954558
33Abnormality of fatty-acid metabolism (HP:0004359)3.46439091
34Anomalous pulmonary venous return (HP:0010772)3.39622762
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38824322
36Hyperbilirubinemia (HP:0002904)3.29069890
37Relative macrocephaly (HP:0004482)3.19331568
38Delayed CNS myelination (HP:0002188)3.12284352
39Ketoacidosis (HP:0001993)3.11910374
40Abnormality of nucleobase metabolism (HP:0010932)3.07706161
41Steatorrhea (HP:0002570)3.01976331
42Abnormality of serum amino acid levels (HP:0003112)2.98909209
43Abnormality of the pulmonary veins (HP:0011718)2.98384384
44Cerebral palsy (HP:0100021)2.98367143
45Myocardial infarction (HP:0001658)2.97434885
46Systemic lupus erythematosus (HP:0002725)2.94253256
47Hepatocellular carcinoma (HP:0001402)2.89136868
48Spontaneous abortion (HP:0005268)2.83890133
49Abnormality of purine metabolism (HP:0004352)2.81721125
50Metabolic acidosis (HP:0001942)2.79220425
51Skin nodule (HP:0200036)2.75618907
52Hypochromic microcytic anemia (HP:0004840)2.73049818
53Vascular calcification (HP:0004934)2.67310531
54Dicarboxylic aciduria (HP:0003215)2.66033894
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66033894
56Mitral stenosis (HP:0001718)2.62741731
57Osteomalacia (HP:0002749)2.62290149
58Large earlobe (HP:0009748)2.62276209
59Lethargy (HP:0001254)2.58422948
60Gout (HP:0001997)2.55191646
61Glomerulonephritis (HP:0000099)2.49732851
62Recurrent gram-negative bacterial infections (HP:0005420)2.45292490
63Spastic diplegia (HP:0001264)2.43052981
64Cardiovascular calcification (HP:0011915)2.39232389
65Amyloidosis (HP:0011034)2.38340588
66Abnormal gallbladder morphology (HP:0012437)2.37474273
67Hypoglycemic seizures (HP:0002173)2.35214957
68Malnutrition (HP:0004395)2.33787795
69Cholelithiasis (HP:0001081)2.32474411
70Acanthocytosis (HP:0001927)2.31937237
71Esophageal varix (HP:0002040)2.31139163
72Arthropathy (HP:0003040)2.30049851
73Generalized aminoaciduria (HP:0002909)2.29801308
74Cerebral edema (HP:0002181)2.29379830
75Irritability (HP:0000737)2.29178746
76Neonatal onset (HP:0003623)2.29004573
77Neonatal hypoglycemia (HP:0001998)2.22967540
78Sensorimotor neuropathy (HP:0007141)2.22956705
79Cholecystitis (HP:0001082)2.22769981
80Abnormal gallbladder physiology (HP:0012438)2.22769981
81Pancreatitis (HP:0001733)2.21611728
82Gingival bleeding (HP:0000225)2.20227871
83Joint swelling (HP:0001386)2.16767489
84Ureteral duplication (HP:0000073)2.16076412
85Menorrhagia (HP:0000132)2.14852121
86Vomiting (HP:0002013)2.14096611
87Abnormality of carpal bone ossification (HP:0006257)2.12265798
88Late onset (HP:0003584)2.11282991
89Thrombophlebitis (HP:0004418)2.10850149
90Enlarged kidneys (HP:0000105)2.09787275
91Diastasis recti (HP:0001540)2.08557588
92Hydroxyprolinuria (HP:0003080)2.06485461
93Abnormality of proline metabolism (HP:0010907)2.06485461
94Brushfield spots (HP:0001088)2.05792575
95Hemorrhage of the eye (HP:0011885)2.05327764
96Rhizomelia (HP:0008905)2.03647945
97Purpura (HP:0000979)1.96984521
98Opisthotonus (HP:0002179)1.96131135
99Alkalosis (HP:0001948)1.96057190
100Renal cortical cysts (HP:0000803)1.95794823
101Abnormality of the gallbladder (HP:0005264)1.95287961
102Protrusio acetabuli (HP:0003179)1.93172944
103Stenosis of the external auditory canal (HP:0000402)1.92586028
104Abnormality of the Achilles tendon (HP:0005109)1.91863653
105Rickets (HP:0002748)1.88643989
106Abnormal cartilage morphology (HP:0002763)1.87653943
107Hyperinsulinemic hypoglycemia (HP:0000825)1.86159514
108Elevated alkaline phosphatase (HP:0003155)1.85455099
109Nephritis (HP:0000123)1.84273438
110Abnormality of iron homeostasis (HP:0011031)1.82922652
111Pulmonary embolism (HP:0002204)1.82680945
112Proximal tubulopathy (HP:0000114)1.82425030
113Elevated hepatic transaminases (HP:0002910)1.82128332
114Poikilocytosis (HP:0004447)1.82007175
115Fair hair (HP:0002286)1.81888510
116Cervical subluxation (HP:0003308)1.81112563
117Abnormality of transition element cation homeostasis (HP:0011030)1.80994488
118Status epilepticus (HP:0002133)1.80880440
119Hypertriglyceridemia (HP:0002155)1.80067021
120Acute hepatic failure (HP:0006554)1.79615771
121Abnormal enzyme/coenzyme activity (HP:0012379)1.79181920
122Reduced antithrombin III activity (HP:0001976)1.78111084
123Mucopolysacchariduria (HP:0008155)1.74704297
124Urinary glycosaminoglycan excretion (HP:0003541)1.74704297
125Hyperglycemia (HP:0003074)1.73047608
126Split foot (HP:0001839)1.65683246
127Increased serum ferritin (HP:0003281)1.65370292
128Abnormal ossification of hand bones (HP:0005921)1.64838522
129Abnormality of the alveolar ridges (HP:0006477)1.64557652
130Abnormality of polysaccharide metabolism (HP:0011012)1.62290769
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62290769
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62290769
133Wrist flexion contracture (HP:0001239)1.59788625
134Abnormality of alkaline phosphatase activity (HP:0004379)1.59520988
135Abnormal hand bone ossification (HP:0010660)1.57521951
136Atrioventricular block (HP:0001678)1.56917248
137Hypophosphatemia (HP:0002148)1.53585103
138Partial agenesis of the corpus callosum (HP:0001338)1.51294235
139Ulnar bowing (HP:0003031)1.49377621
140Bone pain (HP:0002653)1.47961832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B7.71984909
2BCKDK6.82378455
3FGFR44.63900122
4SIK14.48117677
5ERN14.32886047
6DDR22.96037564
7TAOK32.78982523
8INSRR2.67358197
9TRIB32.33779986
10ERBB42.26705551
11PKN22.17704629
12MAP2K42.04021537
13MST1R2.01022690
14TYK21.88997766
15ARAF1.78064303
16FLT31.76589972
17MAPK111.76535546
18PIK3CG1.72721773
19EPHB21.68820615
20FGFR21.61080686
21KDR1.60855216
22LATS21.55426020
23KSR21.53348589
24DAPK21.46403058
25PDK21.39303332
26PTK61.38576303
27NEK91.33483988
28JAK11.30958575
29GRK61.30754232
30MAP3K71.26669799
31TIE11.26658372
32ABL21.26026682
33LATS11.25621966
34JAK21.23685886
35TGFBR21.23505114
36TBK11.20231353
37FRK1.18852021
38MAP3K141.17234239
39CSK1.14875949
40STK381.12357658
41PINK11.12261081
42PRKAA21.11549650
43MAP2K31.09677333
44LMTK21.06190917
45CAMK41.00773893
46MAPK121.00738215
47MAPK40.98352435
48CDC42BPA0.97907933
49EPHB10.97757081
50FGFR30.96291228
51MAP3K90.95772954
52AKT30.95552693
53IKBKE0.88782705
54ICK0.88438818
55EIF2AK30.87117889
56RIPK10.86722580
57PRKCZ0.86128544
58CAMK1D0.84070607
59MAP3K10.81382513
60MAP3K30.81092543
61PDGFRB0.80199320
62IRAK30.78484408
63STK38L0.74289784
64EPHA30.73460499
65PRKACG0.72539476
66SGK30.72172045
67MAP3K100.72157614
68MAP2K60.70045584
69CDK60.69389518
70MET0.68816921
71CAMKK20.68333051
72ERBB20.66001452
73MAPK70.64752649
74TESK10.64369781
75GSK3A0.64253223
76PRKCQ0.63893071
77MOS0.63647594
78FER0.63347906
79PDPK10.63127147
80PRKAA10.61825224
81MAP3K130.61202376
82NTRK10.59942183
83CAMK2G0.59668826
84MTOR0.59478763
85IGF1R0.59035125
86ITK0.57504785
87MAP3K20.57451502
88PTK20.57307424
89MAP3K120.56866303
90ZAP700.56129220
91MAP3K110.55808136
92MAPK30.55444657
93MYLK0.54763221
94MAP4K10.53599673
95GRK10.52159843
96EPHA40.51966979
97NTRK30.51936217
98RAF10.51926351
99TAOK20.50612872
100MAPK150.50503939
101PIM20.50185332
102CSF1R0.49992062
103SGK20.49772250
104MELK0.48914289
105KSR10.46313723
106DYRK1B0.45075611
107PDK10.44825678
108PDK40.43587439
109PDK30.43587439
110MAP2K20.43076122
111LRRK20.39144998
112ROCK10.38517037
113RET0.37870637
114JAK30.36762713
115PAK20.35991885
116MAP3K60.35858548
117CAMK1G0.35282125
118MAP2K10.34936070
119PRKCH0.34836033
120PRKACA0.34412358
121PRKCG0.34233964
122MAPK10.33915738
123SGK4940.33752505
124SGK2230.33752505
125STK240.33468176
126EGFR0.33430482
127BLK0.33087325
128PDGFRA0.33057224
129MAP3K50.32589357
130FGFR10.32202374
131PRKD20.32139256
132ROCK20.31354900
133KIT0.31163413
134CDK40.30908855
135AKT20.30782748
136SRC0.30755710
137MAPKAPK30.29685643
138RPS6KA50.29002634
139CSNK1G10.27773659
140PRKCA0.27493438
141NLK0.25746999
142ABL10.25235535
143BMX0.24678278
144IRAK10.24566345
145TXK0.23998001

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42128237
2Nitrogen metabolism_Homo sapiens_hsa009103.59737788
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40471364
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21521087
5Arginine biosynthesis_Homo sapiens_hsa002202.97156755
6Complement and coagulation cascades_Homo sapiens_hsa046102.74933370
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74442083
8Tryptophan metabolism_Homo sapiens_hsa003802.71379438
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63502891
10Fatty acid degradation_Homo sapiens_hsa000712.57035576
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46344495
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45737698
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29758544
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16799282
15Butanoate metabolism_Homo sapiens_hsa006502.16312259
16Peroxisome_Homo sapiens_hsa041462.11494340
17Propanoate metabolism_Homo sapiens_hsa006402.04116241
18PPAR signaling pathway_Homo sapiens_hsa033201.94293851
19Histidine metabolism_Homo sapiens_hsa003401.91859976
20Fatty acid metabolism_Homo sapiens_hsa012121.90557017
21* Chemical carcinogenesis_Homo sapiens_hsa052041.87339849
22Caffeine metabolism_Homo sapiens_hsa002321.86766306
23* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84576434
24* Steroid hormone biosynthesis_Homo sapiens_hsa001401.82710763
25Staphylococcus aureus infection_Homo sapiens_hsa051501.81169369
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.75691790
27beta-Alanine metabolism_Homo sapiens_hsa004101.75675728
28Retinol metabolism_Homo sapiens_hsa008301.73957641
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66445074
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65277360
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60298130
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53106584
33Selenocompound metabolism_Homo sapiens_hsa004501.52538734
34Bile secretion_Homo sapiens_hsa049761.52405964
35Phenylalanine metabolism_Homo sapiens_hsa003601.51691469
36Pyruvate metabolism_Homo sapiens_hsa006201.41123274
37Tyrosine metabolism_Homo sapiens_hsa003501.38321946
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37373934
39Sulfur metabolism_Homo sapiens_hsa009201.36043524
40Fatty acid elongation_Homo sapiens_hsa000621.33438026
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31057450
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.22149916
43ABC transporters_Homo sapiens_hsa020101.20617051
44Biosynthesis of amino acids_Homo sapiens_hsa012301.16474328
45Carbon metabolism_Homo sapiens_hsa012001.15418554
46Steroid biosynthesis_Homo sapiens_hsa001001.14448072
47Fat digestion and absorption_Homo sapiens_hsa049751.11541190
48Folate biosynthesis_Homo sapiens_hsa007901.10922926
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04878350
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.03390425
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97429986
52Arginine and proline metabolism_Homo sapiens_hsa003300.95899409
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95151419
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92912026
55Sulfur relay system_Homo sapiens_hsa041220.92166269
56Vitamin digestion and absorption_Homo sapiens_hsa049770.88054681
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87354989
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.85299854
59Vitamin B6 metabolism_Homo sapiens_hsa007500.82866196
60Lysine degradation_Homo sapiens_hsa003100.80644573
61Glycerolipid metabolism_Homo sapiens_hsa005610.75293219
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70503002
63Fatty acid biosynthesis_Homo sapiens_hsa000610.69410335
64Glutathione metabolism_Homo sapiens_hsa004800.66984061
65Pentose phosphate pathway_Homo sapiens_hsa000300.65775515
66One carbon pool by folate_Homo sapiens_hsa006700.60934354
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56225265
68* Metabolic pathways_Homo sapiens_hsa011000.44058164
69Mineral absorption_Homo sapiens_hsa049780.36569503
70Other glycan degradation_Homo sapiens_hsa005110.33193431
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31573027
72Prion diseases_Homo sapiens_hsa050200.31405935
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.26635965
74Fructose and mannose metabolism_Homo sapiens_hsa000510.26548494
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25422169
76Insulin resistance_Homo sapiens_hsa049310.25333320
77Galactose metabolism_Homo sapiens_hsa000520.25257151
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21916534
79Linoleic acid metabolism_Homo sapiens_hsa005910.17624436
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.16326094
81ECM-receptor interaction_Homo sapiens_hsa045120.13594242
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10156544
83Glucagon signaling pathway_Homo sapiens_hsa049220.08495152
84Circadian rhythm_Homo sapiens_hsa047100.06851828
85Serotonergic synapse_Homo sapiens_hsa047260.03608568
86AMPK signaling pathway_Homo sapiens_hsa041520.01904837
87Malaria_Homo sapiens_hsa05144-0.2412974
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2363207
89Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2274452
90Pertussis_Homo sapiens_hsa05133-0.2171114
91Amoebiasis_Homo sapiens_hsa05146-0.2088398
92Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2017784
93Lysosome_Homo sapiens_hsa04142-0.1962165
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1670476
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1660526
96Hepatitis C_Homo sapiens_hsa05160-0.1611513
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1532545
98Regulation of autophagy_Homo sapiens_hsa04140-0.1392816
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1360506
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1263019
101Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1215436
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1192812
103African trypanosomiasis_Homo sapiens_hsa05143-0.1164677
104Proteoglycans in cancer_Homo sapiens_hsa05205-0.1127803
105Phagosome_Homo sapiens_hsa04145-0.1048036
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0963303
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0864733
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0840577
109TNF signaling pathway_Homo sapiens_hsa04668-0.0614701
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0480152
111Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0416930
112Sphingolipid metabolism_Homo sapiens_hsa00600-0.0371303

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