HSD11B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)7.57297698
2angiotensin maturation (GO:0002003)7.38516889
3aminoglycoside antibiotic metabolic process (GO:0030647)7.36248961
4urate metabolic process (GO:0046415)7.09747931
5intestinal absorption (GO:0050892)6.90896690
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.68812220
7phosphate ion transport (GO:0006817)6.52227096
8drug transport (GO:0015893)6.49639829
9excretion (GO:0007588)6.26530539
10lysine metabolic process (GO:0006553)6.21581841
11lysine catabolic process (GO:0006554)6.21581841
12positive regulation of respiratory burst (GO:0060267)5.87597928
13organic cation transport (GO:0015695)5.78790431
14quaternary ammonium group transport (GO:0015697)5.75278395
15renal absorption (GO:0070293)5.70822856
16phosphate ion transmembrane transport (GO:0035435)5.50253823
17positive regulation of guanylate cyclase activity (GO:0031284)5.28511132
18cellular ketone body metabolic process (GO:0046950)5.26178872
19response to mercury ion (GO:0046689)5.23357947
20epoxygenase P450 pathway (GO:0019373)5.10966774
21sulfur amino acid catabolic process (GO:0000098)4.90097516
22fat-soluble vitamin biosynthetic process (GO:0042362)4.85586113
23glyoxylate metabolic process (GO:0046487)4.80463254
24drug catabolic process (GO:0042737)4.76914003
25receptor guanylyl cyclase signaling pathway (GO:0007168)4.70296453
26positive regulation of pseudopodium assembly (GO:0031274)4.70182282
27amino-acid betaine transport (GO:0015838)4.67641974
28carnitine transport (GO:0015879)4.67641974
29glomerular filtration (GO:0003094)4.63176509
30bundle of His cell to Purkinje myocyte communication (GO:0086069)4.59747491
31trivalent inorganic anion homeostasis (GO:0072506)4.59735080
32phosphate ion homeostasis (GO:0055062)4.59735080
33exogenous drug catabolic process (GO:0042738)4.57530522
34regulation of cellular extravasation (GO:0002691)4.54452662
35nonribosomal peptide biosynthetic process (GO:0019184)4.54120280
36regulation of cGMP biosynthetic process (GO:0030826)4.53274061
37ketone body metabolic process (GO:1902224)4.50418707
38flavonoid metabolic process (GO:0009812)4.50266782
39cysteine metabolic process (GO:0006534)4.48526883
40tricarboxylic acid metabolic process (GO:0072350)4.46485837
41bile acid and bile salt transport (GO:0015721)4.45680590
42metanephric nephron tubule development (GO:0072234)4.45622122
43metanephric tubule development (GO:0072170)4.45622122
44homocysteine metabolic process (GO:0050667)4.45414609
45maintenance of gastrointestinal epithelium (GO:0030277)4.40637646
46ethanol oxidation (GO:0006069)4.33213502
47antibacterial humoral response (GO:0019731)4.27727995
48vitamin D metabolic process (GO:0042359)4.26036457
49regulation of vitamin metabolic process (GO:0030656)4.23315737
50renal filtration (GO:0097205)4.20918157
51regulation of pseudopodium assembly (GO:0031272)4.18662581
52short-chain fatty acid metabolic process (GO:0046459)4.17754034
53antimicrobial humoral response (GO:0019730)4.17147725
54urea cycle (GO:0000050)4.15598159
55actin filament depolymerization (GO:0030042)4.14749628
56glutathione biosynthetic process (GO:0006750)4.14285347
57regulation of bile acid biosynthetic process (GO:0070857)4.12014096
58metanephric nephron epithelium development (GO:0072243)4.07107504
59diacylglycerol metabolic process (GO:0046339)4.06017048
60oligosaccharide biosynthetic process (GO:0009312)4.00987480
61transcytosis (GO:0045056)3.98695996
62lipoprotein transport (GO:0042953)3.94391166
63desmosome organization (GO:0002934)3.93042144
64nephron tubule development (GO:0072080)3.91258730
65regulation of guanylate cyclase activity (GO:0031282)3.88811687
66urea metabolic process (GO:0019627)3.88348072
67metanephric epithelium development (GO:0072207)3.87681976
68sulfate transmembrane transport (GO:1902358)3.87253288
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.85978305
70aspartate family amino acid catabolic process (GO:0009068)3.79446532
71sulfur compound transport (GO:0072348)3.77081046
72modified amino acid transport (GO:0072337)3.73822245
73nucleoside diphosphate biosynthetic process (GO:0009133)3.73638217
74regulation of cGMP metabolic process (GO:0030823)3.69556487
75hormone catabolic process (GO:0042447)3.68954568
76* regulation of systemic arterial blood pressure by hormone (GO:0001990)3.68897956
77* regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.68897956
78* endocrine process (GO:0050886)3.68897956
79positive regulation of glycoprotein biosynthetic process (GO:0010560)3.65923920
80ethanol metabolic process (GO:0006067)3.64659351
81positive regulation of Cdc42 GTPase activity (GO:0043089)3.63884458
82fructose metabolic process (GO:0006000)3.62805853
83regulation of apoptotic process involved in morphogenesis (GO:1902337)3.62206497
84uronic acid metabolic process (GO:0006063)3.58085836
85glucuronate metabolic process (GO:0019585)3.58085836
86nitrogen cycle metabolic process (GO:0071941)3.51058440
87cellular glucuronidation (GO:0052695)3.50669652
88O-glycan processing (GO:0016266)3.47955267
89sodium ion homeostasis (GO:0055078)3.47927279
90* regulation of systemic arterial blood pressure (GO:0003073)3.47574723
91cellular response to vitamin D (GO:0071305)3.46715539
92GDP-mannose metabolic process (GO:0019673)3.46056552
93regulation of hydrogen peroxide metabolic process (GO:0010310)3.44846671
94positive regulation of glycoprotein metabolic process (GO:1903020)3.44604742
95phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.43643463
96bicarbonate transport (GO:0015701)3.43434719
97regulation of respiratory burst (GO:0060263)3.43322477
98digestive system process (GO:0022600)3.43272093
99renal tubule development (GO:0061326)3.42043331
100branched-chain amino acid metabolic process (GO:0009081)3.40377371
101auditory receptor cell differentiation (GO:0042491)3.39746874
102epithelial structure maintenance (GO:0010669)3.38790979
103fatty acid beta-oxidation (GO:0006635)3.38080868
104cellular modified amino acid catabolic process (GO:0042219)3.33856873
105nephron tubule morphogenesis (GO:0072078)3.32838553
106nephron epithelium morphogenesis (GO:0072088)3.32838553
107collecting duct development (GO:0072044)3.32756398
108vitamin transmembrane transport (GO:0035461)3.32645836
109proline metabolic process (GO:0006560)3.32088487
110carnitine transmembrane transport (GO:1902603)3.31815542
111toxin transport (GO:1901998)3.30876506
112fatty acid oxidation (GO:0019395)3.26043193
113labyrinthine layer development (GO:0060711)3.25686870
114glutathione metabolic process (GO:0006749)3.24348198
115glycoside metabolic process (GO:0016137)3.22648079
116very-low-density lipoprotein particle assembly (GO:0034379)3.20848034
117calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.17997625
118lipid oxidation (GO:0034440)3.17892138
119response to growth hormone (GO:0060416)3.16164488
120hydrogen peroxide catabolic process (GO:0042744)3.15754372
121adhesion of symbiont to host cell (GO:0044650)3.15187463
122virion attachment to host cell (GO:0019062)3.15187463
123nephron epithelium development (GO:0072009)3.14930352
124sulfate transport (GO:0008272)3.14490689
125arginine metabolic process (GO:0006525)3.13552497
126vitamin transport (GO:0051180)3.13209018
127glycosphingolipid catabolic process (GO:0046479)3.12466355
128peptide biosynthetic process (GO:0043043)3.12032227
129valine metabolic process (GO:0006573)3.11144949
130* renal system process involved in regulation of blood volume (GO:0001977)3.08753773
131regulation of mesenchymal cell apoptotic process (GO:2001053)3.08596704
1323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.06997592
133purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.06997592
134glycolipid catabolic process (GO:0019377)3.06502570
135positive regulation of cGMP biosynthetic process (GO:0030828)3.05781803
136positive regulation of lipid catabolic process (GO:0050996)3.05068186
137peptide catabolic process (GO:0043171)3.04475216
138polyol transport (GO:0015791)3.04238418
139digestion (GO:0007586)3.03063895
140sperm capacitation (GO:0048240)3.02493018
141cellular response to vitamin (GO:0071295)3.00710753
142nucleotide-sugar biosynthetic process (GO:0009226)2.99401672
1432-oxoglutarate metabolic process (GO:0006103)2.98711443
144peptide hormone processing (GO:0016486)2.97926734
145tricarboxylic acid cycle (GO:0006099)2.97332156
146carnitine shuttle (GO:0006853)2.96933948
147epithelial cell-cell adhesion (GO:0090136)2.96853722
148multicellular organismal water homeostasis (GO:0050891)2.96511491
149amino-acid betaine metabolic process (GO:0006577)2.94651942
150glutathione derivative metabolic process (GO:1901685)2.93332268
151glutathione derivative biosynthetic process (GO:1901687)2.93332268
152sphingomyelin metabolic process (GO:0006684)2.93209809
153UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93111957
154glycerol metabolic process (GO:0006071)2.92974528
155glutamine family amino acid biosynthetic process (GO:0009084)2.92424970
156drug metabolic process (GO:0017144)2.91364004
157nephron tubule formation (GO:0072079)2.90558922
158serine family amino acid catabolic process (GO:0009071)2.90394214
159cGMP-mediated signaling (GO:0019934)2.88904352
160positive regulation of fatty acid oxidation (GO:0046321)2.88574061
161cellular response to pH (GO:0071467)2.88325784
162NADH metabolic process (GO:0006734)2.85541335
163regulation of cholesterol homeostasis (GO:2000188)2.84726291
164ATP synthesis coupled proton transport (GO:0015986)2.83967529
165energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83967529
166erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83257187
167L-phenylalanine metabolic process (GO:0006558)2.83257187
168fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82910919
169plasma lipoprotein particle assembly (GO:0034377)2.82790651
170neurotransmitter biosynthetic process (GO:0042136)2.81001824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.53504047
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.06724004
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.97390470
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.95710182
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.70272005
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.28527836
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.03786305
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.99498035
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.94651276
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87737503
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.83161564
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.80231002
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.69208872
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65168633
15CLOCK_20551151_ChIP-Seq_293T_Human2.55150063
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.50915674
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.50548162
18AR_21909140_ChIP-Seq_LNCAP_Human2.43691295
19GATA6_25053715_ChIP-Seq_YYC3_Human2.35906463
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.31525306
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.25248215
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.19636710
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15212056
24* RACK7_27058665_Chip-Seq_MCF-7_Human2.12285735
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11852028
26GATA4_25053715_ChIP-Seq_YYC3_Human2.08747622
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05335208
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96228053
29* SOX2_20726797_ChIP-Seq_SW620_Human1.92954214
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.79841591
31LXR_22292898_ChIP-Seq_THP-1_Human1.75905722
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.75881773
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74310786
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72037667
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68043675
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67078200
37* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61754214
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60871953
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.60856495
40* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57449150
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55000111
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47924047
43VDR_22108803_ChIP-Seq_LS180_Human1.47026497
44ATF3_27146783_Chip-Seq_COLON_Human1.46629346
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45419438
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44465365
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43468929
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43351547
49* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40965824
50EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39740234
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.38967966
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.38726696
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36388588
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33493873
55CREB1_26743006_Chip-Seq_LNCaP_Human1.33220677
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31754181
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30209252
58JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.30122036
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28707738
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27376813
61CTCF_27219007_Chip-Seq_Bcells_Human1.25463870
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23985198
63* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23738730
64DROSHA_22980978_ChIP-Seq_HELA_Human1.21300174
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.20299330
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19668088
67* SA1_27219007_Chip-Seq_Bcells_Human1.19425969
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.17275348
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16524060
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16425613
71NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15637949
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12697125
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11777061
74* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11253175
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10913463
76FOXA1_25552417_ChIP-Seq_VCAP_Human1.10846244
77BCOR_27268052_Chip-Seq_Bcells_Human1.09368943
78HNF4A_19822575_ChIP-Seq_HepG2_Human1.09361672
79ZNF263_19887448_ChIP-Seq_K562_Human1.07591598
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.06633864
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06619308
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05962239
83BCL6_27268052_Chip-Seq_Bcells_Human1.05803013
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05504010
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04317155
86* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04287705
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.04246333
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04082833
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03671980
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03609582
91* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03493363
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.03445941
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02965093
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02657367
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01400018
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01375503
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99045276
98KLF5_25053715_ChIP-Seq_YYC3_Human0.99035670
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98609314
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97880265
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97201370
102P68_20966046_ChIP-Seq_HELA_Human0.97181830
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97152773
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.96976596
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96126571
106* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95803439
107EGR1_19032775_ChIP-ChIP_M12_Human0.94348323
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94250053
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93061049
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93001682
111E2F1_20622854_ChIP-Seq_HELA_Human0.92805457
112CEBPB_22108803_ChIP-Seq_LS180_Human0.90636059
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.90284601
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.89893888
115TP63_22573176_ChIP-Seq_HFKS_Human0.89623142
116TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89457287
117ETS1_21867929_ChIP-Seq_TH2_Mouse0.88308250
118PHF8_20622854_ChIP-Seq_HELA_Human0.85580763
119* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84937295
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84864426
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84402879
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81502982
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81482234
124* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81393225
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81350692
126RAC3_21632823_ChIP-Seq_H3396_Human0.80685775
127* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79238355
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78730327
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78730327
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.78677200
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.78677200
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78273667
133CTCF_20526341_ChIP-Seq_ESCs_Human0.78027194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation5.47326043
2MP0005360_urolithiasis4.86695812
3MP0009379_abnormal_foot_pigmentation3.76580529
4MP0004019_abnormal_vitamin_homeostasis3.68052945
5* MP0001765_abnormal_ion_homeostasis3.56901007
6MP0003283_abnormal_digestive_organ3.46679050
7* MP0009643_abnormal_urine_homeostasis3.28940194
8MP0005332_abnormal_amino_acid3.13879092
9MP0005377_hearing/vestibular/ear_phenot3.08152904
10MP0003878_abnormal_ear_physiology3.08152904
11MP0002139_abnormal_hepatobiliary_system3.05884768
12MP0010234_abnormal_vibrissa_follicle2.93115490
13MP0002138_abnormal_hepatobiliary_system2.88613600
14* MP0005636_abnormal_mineral_homeostasis2.86395817
15MP0004264_abnormal_extraembryonic_tissu2.83990370
16MP0003183_abnormal_peptide_metabolism2.83647418
17MP0008875_abnormal_xenobiotic_pharmacok2.58796420
18* MP0001756_abnormal_urination2.48789971
19MP0000537_abnormal_urethra_morphology2.43209210
20* MP0002136_abnormal_kidney_physiology2.39275937
21MP0004147_increased_porphyrin_level2.32710079
22MP0003195_calcinosis2.31640045
23MP0003252_abnormal_bile_duct2.29377396
24MP0001958_emphysema2.28566950
25MP0006054_spinal_hemorrhage2.27027301
26MP0000538_abnormal_urinary_bladder2.26994185
27MP0005409_darkened_coat_color2.18903889
28MP0000462_abnormal_digestive_system1.97084656
29MP0003868_abnormal_feces_composition1.96208577
30MP0003300_gastrointestinal_ulcer1.86160645
31MP0009840_abnormal_foam_cell1.84805522
32MP0003705_abnormal_hypodermis_morpholog1.83311199
33MP0003866_abnormal_defecation1.82349916
34MP0001188_hyperpigmentation1.82323071
35MP0005670_abnormal_white_adipose1.78299748
36MP0003315_abnormal_perineum_morphology1.78020052
37MP0001664_abnormal_digestion1.69551084
38MP0005381_digestive/alimentary_phenotyp1.67039263
39MP0001663_abnormal_digestive_system1.65852036
40MP0004858_abnormal_nervous_system1.63215390
41MP0004782_abnormal_surfactant_physiolog1.63212062
42MP0005365_abnormal_bile_salt1.52545453
43MP0001849_ear_inflammation1.50557373
44MP0005085_abnormal_gallbladder_physiolo1.48443038
45MP0008961_abnormal_basal_metabolism1.48179259
46MP0005058_abnormal_lysosome_morphology1.40603736
47MP0001666_abnormal_nutrient_absorption1.38123956
48MP0000566_synostosis1.38006173
49MP0010329_abnormal_lipoprotein_level1.35154457
50MP0009053_abnormal_anal_canal1.34055157
51MP0002089_abnormal_postnatal_growth/wei1.30231304
52MP0010155_abnormal_intestine_physiology1.29851614
53* MP0000477_abnormal_intestine_morphology1.24253198
54MP0002896_abnormal_bone_mineralization1.21799666
55MP0005167_abnormal_blood-brain_barrier1.21738672
56MP0003879_abnormal_hair_cell1.20256546
57MP0002254_reproductive_system_inflammat1.18727572
58MP0004885_abnormal_endolymph1.17770141
59MP0003693_abnormal_embryo_hatching1.16269690
60MP0004272_abnormal_basement_membrane1.15635454
61MP0010030_abnormal_orbit_morphology1.12131112
62MP0000490_abnormal_crypts_of1.11940754
63MP0005451_abnormal_body_composition1.10823879
64MP0002822_catalepsy1.10752384
65* MP0002135_abnormal_kidney_morphology1.06348492
66MP0002796_impaired_skin_barrier1.05499097
67MP0002928_abnormal_bile_duct1.05143723
68MP0010352_gastrointestinal_tract_polyps1.04146749
69MP0002098_abnormal_vibrissa_morphology1.02727553
70MP0000534_abnormal_ureter_morphology0.99636997
71MP0000678_abnormal_parathyroid_gland0.94692158
72MP0001764_abnormal_homeostasis0.93815725
73MP0000467_abnormal_esophagus_morphology0.92926019
74MP0003566_abnormal_cell_adhesion0.91411877
75MP0002282_abnormal_trachea_morphology0.90820119
76MP0008438_abnormal_cutaneous_collagen0.90065171
77MP0001485_abnormal_pinna_reflex0.84971586
78MP0001873_stomach_inflammation0.84515841
79MP0005319_abnormal_enzyme/_coenzyme0.81607238
80MP0000609_abnormal_liver_physiology0.81172628
81MP0005501_abnormal_skin_physiology0.80655726
82MP0002168_other_aberrant_phenotype0.79214358
83MP0002166_altered_tumor_susceptibility0.77782655
84MP0002115_abnormal_skeleton_extremities0.77102441
85MP0005584_abnormal_enzyme/coenzyme_acti0.77089154
86MP0004484_altered_response_of0.76731671
87* MP0000230_abnormal_systemic_arterial0.75805657
88MP0002971_abnormal_brown_adipose0.74755598
89MP0000163_abnormal_cartilage_morphology0.74312778
90MP0008004_abnormal_stomach_pH0.74118153
91MP0010678_abnormal_skin_adnexa0.73932883
92MP0005666_abnormal_adipose_tissue0.71252409
93MP0002876_abnormal_thyroid_physiology0.71171538
94MP0005166_decreased_susceptibility_to0.69855655
95MP0001727_abnormal_embryo_implantation0.69821223
96MP0002009_preneoplasia0.66951900
97MP0008872_abnormal_physiological_respon0.66888472
98MP0002234_abnormal_pharynx_morphology0.66107391
99MP0002932_abnormal_joint_morphology0.65933397
100MP0001216_abnormal_epidermal_layer0.64220059
101MP0003186_abnormal_redox_activity0.63152139
102MP0003453_abnormal_keratinocyte_physiol0.62847217
103MP0005187_abnormal_penis_morphology0.61682357
104MP0001881_abnormal_mammary_gland0.61348482
105MP0009115_abnormal_fat_cell0.60806866
106MP0000465_gastrointestinal_hemorrhage0.59427695
107MP0003938_abnormal_ear_development0.59394471
108MP0004947_skin_inflammation0.58824347
109MP0003115_abnormal_respiratory_system0.58221905
110MP0000377_abnormal_hair_follicle0.57669683
111MP0002113_abnormal_skeleton_development0.56474142
112MP0005310_abnormal_salivary_gland0.56408674
113MP0003942_abnormal_urinary_system0.55868310
114MP0003638_abnormal_response/metabolism_0.55614152
115MP0000681_abnormal_thyroid_gland0.55009057
116MP0005448_abnormal_energy_balance0.53251225
117MP0002006_tumorigenesis0.53007132
118MP0002249_abnormal_larynx_morphology0.52825822
119MP0001845_abnormal_inflammatory_respons0.52598581
120MP0003718_maternal_effect0.51746947
121MP0005375_adipose_tissue_phenotype0.51640748
122MP0001501_abnormal_sleep_pattern0.51570209
123MP0004742_abnormal_vestibular_system0.51427989
124MP0003122_maternal_imprinting0.50999334
125MP0003191_abnormal_cellular_cholesterol0.50857331
126MP0004233_abnormal_muscle_weight0.50531362
127MP0003806_abnormal_nucleotide_metabolis0.49825315
128* MP0009642_abnormal_blood_homeostasis0.49507671
129MP0005535_abnormal_body_temperature0.49167320
130MP0004270_analgesia0.48793504
131MP0003329_amyloid_beta_deposits0.47529348
132MP0003724_increased_susceptibility_to0.47464825
133MP0005084_abnormal_gallbladder_morpholo0.47280436
134MP0005257_abnormal_intraocular_pressure0.46906181
135MP0002111_abnormal_tail_morphology0.45658374
136MP0005220_abnormal_exocrine_pancreas0.45334353
137MP0003119_abnormal_digestive_system0.44709600
138MP0000762_abnormal_tongue_morphology0.44616929
139MP0002653_abnormal_ependyma_morphology0.44502827
140MP0001270_distended_abdomen0.44400453
141MP0000470_abnormal_stomach_morphology0.43816019
142MP0003941_abnormal_skin_development0.42769866
143MP0006036_abnormal_mitochondrial_physio0.41194942
144MP0002118_abnormal_lipid_homeostasis0.39912580

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.40180214
2* Metabolic alkalosis (HP:0200114)7.62304910
3Abnormality of chloride homeostasis (HP:0011422)7.13921500
4Increased circulating renin level (HP:0000848)6.73765735
5Hypokalemic alkalosis (HP:0001949)6.60742146
6Hypomagnesemia (HP:0002917)6.17905238
7Polyuria (HP:0000103)5.73055354
8Gout (HP:0001997)5.60001983
9Abnormality of magnesium homeostasis (HP:0004921)5.48367078
10Hyperaldosteronism (HP:0000859)5.45962220
11Abnormal urine output (HP:0012590)5.35527911
12Abnormality of renal excretion (HP:0011036)5.04986216
13* Abnormality of renin-angiotensin system (HP:0000847)4.88233451
14Tetany (HP:0001281)4.66619989
15Renal salt wasting (HP:0000127)4.65098319
16Polydipsia (HP:0001959)4.45581203
17Abnormal drinking behavior (HP:0030082)4.45581203
18* Alkalosis (HP:0001948)4.38598919
19Proximal tubulopathy (HP:0000114)4.20899401
20Hyperuricemia (HP:0002149)4.15397746
21Increased purine levels (HP:0004368)4.15397746
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.73937538
23Abnormality of the vitamin B12 metabolism (HP:0004341)3.73188975
24Hypercalciuria (HP:0002150)3.72321241
25* Hypokalemia (HP:0002900)3.59336632
26Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52109730
27Abnormality of purine metabolism (HP:0004352)3.48660468
28Hyperglycinuria (HP:0003108)3.42723752
29Abnormality of vitamin B metabolism (HP:0004340)3.41891826
30Chronic diarrhea (HP:0002028)3.34068174
31Systemic lupus erythematosus (HP:0002725)3.26564418
32Generalized aminoaciduria (HP:0002909)3.21750733
33Pili torti (HP:0003777)3.18765274
34Confusion (HP:0001289)3.13899256
35Hemorrhage of the eye (HP:0011885)3.10671200
36Fat malabsorption (HP:0002630)3.05439829
37Abnormal tarsal ossification (HP:0008369)3.02066827
38Delayed epiphyseal ossification (HP:0002663)3.00440803
39Malnutrition (HP:0004395)2.99979896
40Abnormality of sodium homeostasis (HP:0010931)2.99761623
41Hyponatremia (HP:0002902)2.98817599
42Abnormality of vitamin metabolism (HP:0100508)2.89241008
43Hypotension (HP:0002615)2.86703136
44* Abnormality of potassium homeostasis (HP:0011042)2.85855878
45Renal tubular acidosis (HP:0001947)2.79429600
46Abnormality of proline metabolism (HP:0010907)2.79311924
47Hydroxyprolinuria (HP:0003080)2.79311924
48Congenital sensorineural hearing impairment (HP:0008527)2.78964171
49Abnormality of urine glucose concentration (HP:0011016)2.78623199
50Glycosuria (HP:0003076)2.78623199
51Abnormality of small intestinal villus morphology (HP:0011472)2.72315699
52Villous atrophy (HP:0011473)2.72315699
53Thin bony cortex (HP:0002753)2.71804833
54Dehydration (HP:0001944)2.71557266
55Abnormality of carpal bone ossification (HP:0006257)2.65496823
56Adrenal overactivity (HP:0002717)2.60683390
57Intrahepatic cholestasis (HP:0001406)2.59396672
58Abnormality of serine family amino acid metabolism (HP:0010894)2.59164124
59Abnormality of glycine metabolism (HP:0010895)2.59164124
60Abnormality of fatty-acid metabolism (HP:0004359)2.51779196
61Ileus (HP:0002595)2.47849189
62Focal segmental glomerulosclerosis (HP:0000097)2.42855083
63Abnormal hair laboratory examination (HP:0003328)2.41795182
64Flattened epiphyses (HP:0003071)2.40951670
65Abnormal ossification of hand bones (HP:0005921)2.39027848
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38915849
67Dicarboxylic aciduria (HP:0003215)2.38915849
68Abnormality of nucleobase metabolism (HP:0010932)2.38822526
69Nephrolithiasis (HP:0000787)2.37705681
70Nephrocalcinosis (HP:0000121)2.37180628
71Hyperphosphaturia (HP:0003109)2.34750826
72Widely patent fontanelles and sutures (HP:0004492)2.34483472
73Hyperkalemia (HP:0002153)2.30575189
74Ketoacidosis (HP:0001993)2.29904524
75Hypobetalipoproteinemia (HP:0003563)2.26949482
76Abnormal urine phosphate concentration (HP:0012599)2.22415384
77Vacuolated lymphocytes (HP:0001922)2.22365313
78Flat acetabular roof (HP:0003180)2.19172085
79Abnormal foot bone ossification (HP:0010675)2.16667153
80Abnormal hand bone ossification (HP:0010660)2.15678911
81Metaphyseal cupping (HP:0003021)2.15176323
82Neonatal short-limb short stature (HP:0008921)2.13447063
83Acanthocytosis (HP:0001927)2.13442254
84Xanthomatosis (HP:0000991)2.11643405
85Hypophosphatemia (HP:0002148)2.10728606
86Hemangiomatosis (HP:0007461)2.08440723
87Conjugated hyperbilirubinemia (HP:0002908)2.02910130
88Abnormal biliary tract morphology (HP:0012440)2.01707101
89Hyperphosphatemia (HP:0002905)2.01242140
90Vascular calcification (HP:0004934)2.01049447
91Megaloblastic anemia (HP:0001889)2.00791030
92Bicornuate uterus (HP:0000813)2.00446362
93Chondrocalcinosis (HP:0000934)1.99943533
94Pigmentary retinal degeneration (HP:0001146)1.99092639
95Ketosis (HP:0001946)1.93524154
96Abdominal distention (HP:0003270)1.92832438
97Rectal prolapse (HP:0002035)1.92020639
98* Decreased circulating renin level (HP:0003351)1.90752150
99Vomiting (HP:0002013)1.90366872
100Abnormality of the costochondral junction (HP:0000919)1.89710554
101Aortic dissection (HP:0002647)1.88984650
102Syncope (HP:0001279)1.88631843
103Rickets (HP:0002748)1.86563367
104Symptomatic seizures (HP:0011145)1.86063064
105Cardiovascular calcification (HP:0011915)1.86028627
106Enlarged epiphyses (HP:0010580)1.86022997
107Abnormality of complement system (HP:0005339)1.85950713
108Abnormality of the 1st metacarpal (HP:0010009)1.85297691
109Glomerulonephritis (HP:0000099)1.83888167
110Right ventricular cardiomyopathy (HP:0011663)1.83624038
111Glomerulosclerosis (HP:0000096)1.83055211
112Hyperammonemia (HP:0001987)1.82866737
113Abnormality of Sharpey fibers (HP:0100685)1.82578207
114Flat capital femoral epiphysis (HP:0003370)1.80400820
115Neonatal onset (HP:0003623)1.80182376
116Aortic aneurysm (HP:0004942)1.79729872
117Abnormal enzyme/coenzyme activity (HP:0012379)1.78917646
118Lymphangioma (HP:0100764)1.77457865
119Abnormality of alkaline phosphatase activity (HP:0004379)1.77216287
120Ureteral stenosis (HP:0000071)1.74843724
121Hyperparathyroidism (HP:0000843)1.73855763
122Abnormal cartilage morphology (HP:0002763)1.73510377
123Bilateral sensorineural hearing impairment (HP:0008619)1.72787928
124Potter facies (HP:0002009)1.72578723
125Facial shape deformation (HP:0011334)1.72578723
126Enlarged kidneys (HP:0000105)1.71629328
127Visceral angiomatosis (HP:0100761)1.71205058
128Petechiae (HP:0000967)1.70752724
129Tubulointerstitial fibrosis (HP:0005576)1.68721125
130Arterial tortuosity (HP:0005116)1.65516959
131Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63460488
132Short phalanx of the thumb (HP:0009660)1.63284226
133Abnormal pancreas size (HP:0012094)1.61577000
134Nausea (HP:0002018)1.61122134
135Wide cranial sutures (HP:0010537)1.60835285
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.58150092
137Spastic diplegia (HP:0001264)1.57714763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.20684516
2WNK36.16473919
3ACVR1B5.54918894
4OXSR15.49425647
5EPHA24.99282995
6STK393.14168202
7MST1R2.89479614
8STK38L2.46122728
9EPHB22.44102288
10BCKDK2.31664607
11MST42.24916476
12MYLK2.20455893
13MAP3K72.11227189
14PASK1.99293541
15PAK41.94069011
16MAP2K21.85647532
17FRK1.78616687
18NEK11.65817501
19LMTK21.61211799
20PTK61.51534126
21ERN11.46592561
22TESK11.43614530
23TRIB31.41524520
24STK241.36004117
25LRRK21.34701454
26MAP3K101.33232879
27SMG11.32129328
28PRPF4B1.26871678
29TNIK1.23577537
30TGFBR21.20919577
31WNK11.12878887
32SGK4941.06160844
33SGK2231.06160844
34MET1.04750356
35LATS11.04570796
36TESK21.02477544
37PDK31.00884686
38PDK41.00884686
39PTK20.96063623
40MATK0.92385900
41STK380.92045282
42PIK3CA0.88575226
43TTN0.88243502
44NME10.87231040
45DMPK0.86789175
46RIPK10.86684342
47PKN20.86681886
48PRKCI0.86480196
49PDK20.85503401
50PRKG20.85449015
51ERBB20.85156797
52EPHA30.84108718
53CDC42BPA0.83036468
54MAP3K120.82952366
55CAMKK10.81957013
56STK100.76008105
57MAP3K10.74244783
58GRK60.73678630
59AKT30.70797478
60KSR20.70293042
61FER0.69150020
62KSR10.68402857
63DYRK1B0.67769462
64NUAK10.66947898
65MAP3K20.66240295
66MAP3K80.64564887
67MAP2K10.63693908
68PDGFRA0.63140197
69EPHB10.62415401
70FGFR40.61315364
71LIMK10.60695612
72PRKAA20.59472488
73NLK0.58775574
74FGFR30.58127708
75PAK20.57725822
76DDR20.57619340
77TIE10.55099899
78PAK10.54254491
79TYK20.53964383
80SIK10.53162316
81CAMK2D0.51477795
82TAOK10.49422591
83RPS6KA20.49139942
84ROCK10.48945676
85GSK3A0.47968492
86ICK0.47950178
87PRKACG0.47450383
88ROCK20.46867324
89PRKAA10.44303279
90PAK30.43305729
91RIPK40.42776407
92EPHA40.41877771
93KDR0.41223605
94CAMK1D0.41001050
95SCYL20.40536511
96PDK10.39790651
97SGK30.39752703
98PDPK10.39194134
99MAP3K30.38045491
100AKT20.37684653
101ILK0.36448771
102PIK3CG0.36411477
103PRKCA0.36102064
104MAPKAPK30.35887435
105TTK0.35579509
106MAP3K110.35291390
107MAP4K10.34623846
108CSNK1A10.33568911
109STK110.30950239
110PRKCZ0.30196445
111SRC0.30182466
112ABL20.29717626
113EEF2K0.29008222
114MAPK110.28256211
115RET0.27739702
116FGFR10.26590399
117NEK90.25980638
118CDK190.24875920
119RPS6KL10.24695177
120RPS6KC10.24695177
121YES10.24460833
122DAPK30.24002920
123SGK20.22995148
124CAMK1G0.22875133
125MAP2K60.22202651
126MAPKAPK20.22175280
127PRKCD0.20605506
128MTOR0.20591161
129ARAF0.20072459
130AURKB0.19325960
131PTK2B0.18037079
132RPS6KA10.17961573
133BMX0.17312128
134SGK10.17115598
135FYN0.16742263
136RPS6KA60.13493854
137GRK10.11931921
138NEK60.11866837
139CDK60.10528106
140CASK0.10068163
141TBK10.09297882
142BRAF0.07708819

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.21912706
2Sulfur metabolism_Homo sapiens_hsa009203.98840810
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.54999906
4Butanoate metabolism_Homo sapiens_hsa006503.36266953
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.33778431
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.26827442
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86448117
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.84005905
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72899116
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54542558
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45501526
12Propanoate metabolism_Homo sapiens_hsa006402.39794678
13Mineral absorption_Homo sapiens_hsa049782.38947877
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08267810
15Fatty acid degradation_Homo sapiens_hsa000712.04178444
16Bile secretion_Homo sapiens_hsa049762.02964967
17Caffeine metabolism_Homo sapiens_hsa002322.02538306
18Pyruvate metabolism_Homo sapiens_hsa006201.96916248
19Glutathione metabolism_Homo sapiens_hsa004801.83696382
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.79944952
21Tryptophan metabolism_Homo sapiens_hsa003801.79275875
22Carbon metabolism_Homo sapiens_hsa012001.78177294
23Peroxisome_Homo sapiens_hsa041461.56790641
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52571244
25Vitamin digestion and absorption_Homo sapiens_hsa049771.51443440
26Protein digestion and absorption_Homo sapiens_hsa049741.41708689
27Collecting duct acid secretion_Homo sapiens_hsa049661.30047007
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29323052
29Fructose and mannose metabolism_Homo sapiens_hsa000511.29012471
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26020198
31beta-Alanine metabolism_Homo sapiens_hsa004101.25291158
32Fatty acid metabolism_Homo sapiens_hsa012121.23160546
33Histidine metabolism_Homo sapiens_hsa003401.22317259
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19475277
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18422290
36Arginine and proline metabolism_Homo sapiens_hsa003301.16664844
37Oxidative phosphorylation_Homo sapiens_hsa001901.14796146
38PPAR signaling pathway_Homo sapiens_hsa033201.11103362
39Other glycan degradation_Homo sapiens_hsa005111.10343202
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08684024
41* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99046834
42Pentose phosphate pathway_Homo sapiens_hsa000300.98979395
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95374802
44Starch and sucrose metabolism_Homo sapiens_hsa005000.95140796
45Lysine degradation_Homo sapiens_hsa003100.94754062
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.90708686
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89484076
48Renin-angiotensin system_Homo sapiens_hsa046140.88266402
49Chemical carcinogenesis_Homo sapiens_hsa052040.83450470
50Parkinsons disease_Homo sapiens_hsa050120.79888989
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79136717
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76474691
53Thyroid hormone synthesis_Homo sapiens_hsa049180.75779474
54Phenylalanine metabolism_Homo sapiens_hsa003600.74858804
55Nitrogen metabolism_Homo sapiens_hsa009100.74722035
56Ether lipid metabolism_Homo sapiens_hsa005650.73833373
57Biosynthesis of amino acids_Homo sapiens_hsa012300.72897126
58Arachidonic acid metabolism_Homo sapiens_hsa005900.70829487
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70713628
60Glycerolipid metabolism_Homo sapiens_hsa005610.68811171
61Tight junction_Homo sapiens_hsa045300.68556098
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65721767
63Retinol metabolism_Homo sapiens_hsa008300.64624579
64Selenocompound metabolism_Homo sapiens_hsa004500.61690925
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.60772170
66Asthma_Homo sapiens_hsa053100.57488788
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56386223
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.56305709
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.55245613
70Gastric acid secretion_Homo sapiens_hsa049710.52815794
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52640713
72Fat digestion and absorption_Homo sapiens_hsa049750.51702715
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50433111
74Folate biosynthesis_Homo sapiens_hsa007900.50243814
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.49303247
76Alzheimers disease_Homo sapiens_hsa050100.49274049
77Metabolic pathways_Homo sapiens_hsa011000.48180852
78Basal cell carcinoma_Homo sapiens_hsa052170.46327111
79Vibrio cholerae infection_Homo sapiens_hsa051100.45133411
80Arginine biosynthesis_Homo sapiens_hsa002200.44848553
81Hedgehog signaling pathway_Homo sapiens_hsa043400.43250249
82Lysosome_Homo sapiens_hsa041420.41025337
83Pancreatic secretion_Homo sapiens_hsa049720.40548121
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40445101
85Hippo signaling pathway_Homo sapiens_hsa043900.40001931
86Hepatitis C_Homo sapiens_hsa051600.37539284
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37400270
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.37382588
89ECM-receptor interaction_Homo sapiens_hsa045120.36802400
90Cardiac muscle contraction_Homo sapiens_hsa042600.36557363
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.36391334
92Sulfur relay system_Homo sapiens_hsa041220.36212075
93Autoimmune thyroid disease_Homo sapiens_hsa053200.35358636
94Galactose metabolism_Homo sapiens_hsa000520.34781752
95Bladder cancer_Homo sapiens_hsa052190.33008844
96Renin secretion_Homo sapiens_hsa049240.32762579
97Huntingtons disease_Homo sapiens_hsa050160.29432189
98* Steroid hormone biosynthesis_Homo sapiens_hsa001400.28154065
99Staphylococcus aureus infection_Homo sapiens_hsa051500.27788446
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25808483
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24925219
102Adherens junction_Homo sapiens_hsa045200.24834247
103Allograft rejection_Homo sapiens_hsa053300.24509717
104Fatty acid biosynthesis_Homo sapiens_hsa000610.24198458
105Linoleic acid metabolism_Homo sapiens_hsa005910.23938850
106Tyrosine metabolism_Homo sapiens_hsa003500.20276320
107Thyroid cancer_Homo sapiens_hsa052160.17760853
108Fatty acid elongation_Homo sapiens_hsa000620.17699207
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.17136888
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16703028
111Graft-versus-host disease_Homo sapiens_hsa053320.15733045
112Proteoglycans in cancer_Homo sapiens_hsa052050.13776276
113Focal adhesion_Homo sapiens_hsa045100.12715725
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.12058349
115Insulin resistance_Homo sapiens_hsa049310.11975453
116Sphingolipid metabolism_Homo sapiens_hsa006000.11894389
117Glucagon signaling pathway_Homo sapiens_hsa049220.11397231
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11389943
119TGF-beta signaling pathway_Homo sapiens_hsa043500.11177136
120Ovarian steroidogenesis_Homo sapiens_hsa049130.07517742
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06470906
122AMPK signaling pathway_Homo sapiens_hsa041520.05514947
123Type I diabetes mellitus_Homo sapiens_hsa049400.04779287
124Choline metabolism in cancer_Homo sapiens_hsa052310.02910617
125Antigen processing and presentation_Homo sapiens_hsa046120.01844490
126GnRH signaling pathway_Homo sapiens_hsa049120.01306377

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