HSD17B11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.55598929
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55598929
3L-phenylalanine metabolic process (GO:0006558)6.31744326
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.31744326
5aromatic amino acid family catabolic process (GO:0009074)5.91915363
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.76103434
7glyoxylate metabolic process (GO:0046487)5.45377351
8tryptophan catabolic process (GO:0006569)5.34829745
9indole-containing compound catabolic process (GO:0042436)5.34829745
10indolalkylamine catabolic process (GO:0046218)5.34829745
11alpha-linolenic acid metabolic process (GO:0036109)5.34079810
12cysteine metabolic process (GO:0006534)5.24084752
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.19422568
14bile acid biosynthetic process (GO:0006699)5.16444742
15kynurenine metabolic process (GO:0070189)5.13784453
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.11077856
17tryptophan metabolic process (GO:0006568)5.06143247
18sulfur amino acid catabolic process (GO:0000098)4.98908007
19antigen processing and presentation of endogenous antigen (GO:0019883)4.88766713
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85011386
21urea metabolic process (GO:0019627)4.81997641
22urea cycle (GO:0000050)4.81997641
23high-density lipoprotein particle remodeling (GO:0034375)4.79183650
24lysine catabolic process (GO:0006554)4.71294793
25lysine metabolic process (GO:0006553)4.71294793
26peptidyl-glutamic acid carboxylation (GO:0017187)4.64647442
27protein carboxylation (GO:0018214)4.64647442
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54625604
29homocysteine metabolic process (GO:0050667)4.54292227
30complement activation, alternative pathway (GO:0006957)4.53818225
31regulation of triglyceride catabolic process (GO:0010896)4.51105981
32drug catabolic process (GO:0042737)4.50271223
33serine family amino acid catabolic process (GO:0009071)4.50197764
34positive regulation of gamma-delta T cell activation (GO:0046645)4.47312460
35negative regulation of fibrinolysis (GO:0051918)4.45801761
36regulation of cholesterol esterification (GO:0010872)4.45648464
37bile acid metabolic process (GO:0008206)4.45640950
38amino-acid betaine metabolic process (GO:0006577)4.43931117
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.43706838
40negative regulation of cell killing (GO:0031342)4.43706838
41nitrogen cycle metabolic process (GO:0071941)4.43095411
42neutrophil activation involved in immune response (GO:0002283)4.41660795
43reverse cholesterol transport (GO:0043691)4.36586054
44regulation of protein activation cascade (GO:2000257)4.33725318
45detection of other organism (GO:0098543)4.30891554
46drug transmembrane transport (GO:0006855)4.30439901
47angiotensin maturation (GO:0002003)4.29019265
48negative regulation of sterol transport (GO:0032372)4.28561800
49negative regulation of cholesterol transport (GO:0032375)4.28561800
50aromatic amino acid family metabolic process (GO:0009072)4.28061152
51phospholipid efflux (GO:0033700)4.27773138
52plasma lipoprotein particle remodeling (GO:0034369)4.24780719
53protein-lipid complex remodeling (GO:0034368)4.24780719
54macromolecular complex remodeling (GO:0034367)4.24780719
55positive regulation by symbiont of host defense response (GO:0052509)4.24147128
56modulation by symbiont of host defense response (GO:0052031)4.24147128
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.24147128
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.24147128
59positive regulation by organism of defense response of other organism involved in symbiotic interact4.24147128
60modulation by symbiont of host immune response (GO:0052553)4.24147128
61regulation of fibrinolysis (GO:0051917)4.23657181
62cellular ketone body metabolic process (GO:0046950)4.14839222
63cellular glucuronidation (GO:0052695)4.11706201
64urate metabolic process (GO:0046415)4.11386706
65detection of bacterium (GO:0016045)4.11050927
66regulation of complement activation (GO:0030449)4.10947827
67tyrosine metabolic process (GO:0006570)4.04946393
68alpha-amino acid catabolic process (GO:1901606)4.04801964
69plasma lipoprotein particle clearance (GO:0034381)4.04597894
70cellular modified amino acid catabolic process (GO:0042219)3.99803423
71triglyceride homeostasis (GO:0070328)3.97917185
72acylglycerol homeostasis (GO:0055090)3.97917185
73ethanol oxidation (GO:0006069)3.97272899
74exogenous drug catabolic process (GO:0042738)3.96954418
75cholesterol efflux (GO:0033344)3.91052568
76short-chain fatty acid metabolic process (GO:0046459)3.90067938
77glutamate metabolic process (GO:0006536)3.88842370
78bile acid and bile salt transport (GO:0015721)3.87834119
79detection of external biotic stimulus (GO:0098581)3.84240422
80cellular amino acid catabolic process (GO:0009063)3.83871231
81flavonoid metabolic process (GO:0009812)3.82695953
82glucuronate metabolic process (GO:0019585)3.79661273
83uronic acid metabolic process (GO:0006063)3.79661273
84indolalkylamine metabolic process (GO:0006586)3.75963916
85regulation of cholesterol homeostasis (GO:2000188)3.74977888
86benzene-containing compound metabolic process (GO:0042537)3.74001301
87plasma lipoprotein particle assembly (GO:0034377)3.73299791
88serine family amino acid metabolic process (GO:0009069)3.73018581
89detection of molecule of bacterial origin (GO:0032490)3.71781682
90positive regulation of lipoprotein lipase activity (GO:0051006)3.71130055
91positive regulation of triglyceride lipase activity (GO:0061365)3.71130055
92coenzyme catabolic process (GO:0009109)3.68297990
93dicarboxylic acid biosynthetic process (GO:0043650)3.65250107
94epoxygenase P450 pathway (GO:0019373)3.64446298
95amine catabolic process (GO:0009310)3.63704116
96cellular biogenic amine catabolic process (GO:0042402)3.63704116
97response to peptidoglycan (GO:0032494)3.63480355
98drug transport (GO:0015893)3.63040621
99aldehyde catabolic process (GO:0046185)3.62242018
100macrophage activation involved in immune response (GO:0002281)3.62039084
101phospholipid homeostasis (GO:0055091)3.61729263
102cholesterol homeostasis (GO:0042632)3.60883060
103ketone body metabolic process (GO:1902224)3.60056547
104positive regulation of lipid catabolic process (GO:0050996)3.59419262
105regulation of B cell receptor signaling pathway (GO:0050855)3.59011500
106fatty acid beta-oxidation (GO:0006635)3.58564465
107sterol homeostasis (GO:0055092)3.58555919
108fatty acid oxidation (GO:0019395)3.54379953
109low-density lipoprotein particle remodeling (GO:0034374)3.53096528
110regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.52185593
111lipid oxidation (GO:0034440)3.50107843
112organic acid catabolic process (GO:0016054)3.49266680
113carboxylic acid catabolic process (GO:0046395)3.49266680
114acetyl-CoA metabolic process (GO:0006084)3.49158545
115immunoglobulin mediated immune response (GO:0016064)3.47841999
116protein-lipid complex assembly (GO:0065005)3.46862683
117carnitine metabolic process (GO:0009437)3.45637857
118monocarboxylic acid catabolic process (GO:0072329)3.43411059
119lipoprotein transport (GO:0042953)3.43119354
120serine family amino acid biosynthetic process (GO:0009070)3.42820130
121cellular extravasation (GO:0045123)3.42809752
122glycine metabolic process (GO:0006544)3.42162241
123aspartate family amino acid catabolic process (GO:0009068)3.41333969
124regulation of bile acid biosynthetic process (GO:0070857)3.41093051
125lipoprotein metabolic process (GO:0042157)3.39781459
126fatty acid catabolic process (GO:0009062)3.39336914
127drug metabolic process (GO:0017144)3.37893024
128detection of biotic stimulus (GO:0009595)3.37447818
129fat-soluble vitamin biosynthetic process (GO:0042362)3.36518824
130regulation of gamma-delta T cell activation (GO:0046643)3.33693024
131neutrophil activation (GO:0042119)3.30776892
132regulation of interferon-beta biosynthetic process (GO:0045357)3.20364027
133regulation of gamma-delta T cell differentiation (GO:0045586)3.20089085
134antigen processing and presentation via MHC class Ib (GO:0002475)3.15767888
135very-low-density lipoprotein particle assembly (GO:0034379)3.14734184
136microglial cell activation (GO:0001774)3.11751563
137regulation of mast cell degranulation (GO:0043304)3.05006565
138negative regulation of lymphocyte mediated immunity (GO:0002707)3.00863359
139regulation of cellular extravasation (GO:0002691)3.00792985
140respiratory burst (GO:0045730)2.99807276
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99764600
142granulocyte activation (GO:0036230)2.93797812
143negative regulation of interleukin-12 production (GO:0032695)2.93294535
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85934695
145response to host immune response (GO:0052572)2.85681829
146response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85681829
147intestinal absorption (GO:0050892)2.83121199
148myeloid cell activation involved in immune response (GO:0002275)2.80419147
149macrophage activation (GO:0042116)2.80293005
150response to interleukin-15 (GO:0070672)2.79588231
151regulation of leukocyte degranulation (GO:0043300)2.77679852
152regulation of mast cell activation involved in immune response (GO:0033006)2.76579137
153interferon-gamma-mediated signaling pathway (GO:0060333)2.74399563
154leukotriene metabolic process (GO:0006691)2.73869366
155B cell mediated immunity (GO:0019724)2.73813556
156positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.72979604
157positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71120285
158leukocyte migration involved in inflammatory response (GO:0002523)2.70503878
159peptide catabolic process (GO:0043171)2.69666999
160positive regulation of B cell differentiation (GO:0045579)2.69357892
161leukocyte aggregation (GO:0070486)2.65574008
162positive regulation of mast cell activation (GO:0033005)2.64768159
163response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64588924
164response to host (GO:0075136)2.64588924
165response to host defenses (GO:0052200)2.64588924
166positive regulation of antigen processing and presentation (GO:0002579)2.64521015
167negative regulation of leukocyte mediated immunity (GO:0002704)2.63769479
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62281195
169B cell receptor signaling pathway (GO:0050853)2.60678414
170neutrophil mediated immunity (GO:0002446)2.60412274
171dendritic cell chemotaxis (GO:0002407)2.59810302
172regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59586299
173dendritic cell migration (GO:0036336)2.57574440
174regulation of mast cell activation (GO:0033003)2.57209492
175regulation of antigen processing and presentation (GO:0002577)2.56210240
176regulation of tolerance induction (GO:0002643)2.56192286
177glycosphingolipid catabolic process (GO:0046479)2.55976339
178positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54138619
179maintenance of gastrointestinal epithelium (GO:0030277)2.52257746
180regulation of T cell mediated cytotoxicity (GO:0001914)2.51614987
181positive regulation of mast cell activation involved in immune response (GO:0033008)2.50938056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.26635780
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.31968848
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.76857244
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.51233501
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82015281
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.41325458
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.10002237
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.87674621
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45716208
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19714569
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09071560
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99105003
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80286796
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61141341
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45659032
16* SPI1_23547873_ChIP-Seq_NB4_Human2.42559587
17RUNX_20019798_ChIP-Seq_JUKART_Human2.33847590
18VDR_24763502_ChIP-Seq_THP-1_Human2.21716740
19MYB_26560356_Chip-Seq_TH2_Human2.15193950
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09046024
21SPI1_23127762_ChIP-Seq_K562_Human2.05547572
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03766948
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02703283
24SCL_19346495_ChIP-Seq_HPC-7_Human2.00112898
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0030916
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98040267
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96420586
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95175377
29CLOCK_20551151_ChIP-Seq_293T_Human1.88948870
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87769025
31VDR_21846776_ChIP-Seq_THP-1_Human1.85731576
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.83235804
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.82450530
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80532733
35MYB_26560356_Chip-Seq_TH1_Human1.78996227
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73985443
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73494082
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73212024
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67745253
40* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64970233
41MAF_26560356_Chip-Seq_TH1_Human1.63755153
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.58287570
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57287470
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53860296
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51123118
46GATA1_22025678_ChIP-Seq_K562_Human1.48654801
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48484184
48UTX_26944678_Chip-Seq_JUKART_Human1.47608077
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46934414
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46714520
51GATA3_27048872_Chip-Seq_THYMUS_Human1.46682287
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43007467
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42934171
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40766470
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40223485
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38619849
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.38528516
58GATA3_26560356_Chip-Seq_TH2_Human1.38242205
59* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36237994
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35854364
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.35795533
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.34251725
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31005189
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.26584498
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25984270
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25698260
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22022437
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.21801864
69* GATA4_25053715_ChIP-Seq_YYC3_Human1.20631096
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20603596
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19647794
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18858777
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15857906
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14957314
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13552938
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11135408
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.08548933
78TCF7_22412390_ChIP-Seq_EML_Mouse1.07921388
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06012892
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05781646
81* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04609744
82PU_27001747_Chip-Seq_BMDM_Mouse1.04530948
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02770926
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01001785
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99153944
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.97893224
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95390110
88PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93229586
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93131340
90HTT_18923047_ChIP-ChIP_STHdh_Human0.93101423
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93056787
92LXR_22292898_ChIP-Seq_THP-1_Human0.92466247
93BCL6_27268052_Chip-Seq_Bcells_Human0.92302142
94IRF8_21731497_ChIP-ChIP_J774_Mouse0.91546547
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91459777
96MAF_26560356_Chip-Seq_TH2_Human0.91260114
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90366014
98SOX2_20726797_ChIP-Seq_SW620_Human0.89899306
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88830584
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87868783
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87868783
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85346977
103TRIM28_21343339_ChIP-Seq_HEK293_Human0.83807749
104GATA6_25053715_ChIP-Seq_YYC3_Human0.83780798
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83653068
106BCOR_27268052_Chip-Seq_Bcells_Human0.81975142
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81184495
108MYC_22102868_ChIP-Seq_BL_Human0.79897686
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76583735
110EGR1_19032775_ChIP-ChIP_M12_Human0.74780428
111GATA2_19941826_ChIP-Seq_K562_Human0.74636551
112GATA1_19941826_ChIP-Seq_K562_Human0.73840254
113RACK7_27058665_Chip-Seq_MCF-7_Human0.73449319
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72849597
115* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72705805
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72047779
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70797884
118ZNF263_19887448_ChIP-Seq_K562_Human0.70033684
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69569787
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.69426549
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68296138
122TP63_17297297_ChIP-ChIP_HaCaT_Human0.67185178
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66949904
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65969677
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65752888
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65106453
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.64981708
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.64652158
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64078363
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.63366051
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62656663
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.62614680
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60560837
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59501161
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.59486836
136CEBPB_22108803_ChIP-Seq_LS180_Human0.59370238
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59151018
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59083733
139* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.57691135
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57264217
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.56478552
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56463662
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.56326565
144MYC_19915707_ChIP-ChIP_AK7_Human0.54508237
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.54505486
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.54505486
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54351846
148VDR_24787735_ChIP-Seq_THP-1_Human0.53654300
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.52665285
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.52005244
151P63_26484246_Chip-Seq_KERATINOCYTES_Human0.51979581
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.51574611
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51184228
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50824849
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.50758747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.59005148
2MP0005360_urolithiasis7.42817253
3MP0005085_abnormal_gallbladder_physiolo5.54107067
4MP0005365_abnormal_bile_salt5.27745999
5MP0008875_abnormal_xenobiotic_pharmacok4.85010337
6MP0003252_abnormal_bile_duct3.72088208
7MP0003806_abnormal_nucleotide_metabolis3.53222367
8MP0009840_abnormal_foam_cell3.49791711
9MP0010329_abnormal_lipoprotein_level3.26775469
10MP0001835_abnormal_antigen_presentation3.05729310
11MP0005332_abnormal_amino_acid2.91480343
12MP0001666_abnormal_nutrient_absorption2.75687110
13MP0005083_abnormal_biliary_tract2.62738828
14MP0003191_abnormal_cellular_cholesterol2.58534957
15MP0004019_abnormal_vitamin_homeostasis2.50471570
16MP0003195_calcinosis2.46236406
17MP0003183_abnormal_peptide_metabolism2.38830543
18MP0002138_abnormal_hepatobiliary_system2.29018326
19MP0001800_abnormal_humoral_immune2.14338695
20MP0005000_abnormal_immune_tolerance2.10242838
21MP0005671_abnormal_response_to2.07639694
22MP0000685_abnormal_immune_system2.04112269
23MP0002118_abnormal_lipid_homeostasis2.02791725
24MP0005387_immune_system_phenotype2.02618669
25MP0001790_abnormal_immune_system2.02618669
26MP0000609_abnormal_liver_physiology2.00434764
27MP0002148_abnormal_hypersensitivity_rea1.94895245
28MP0002723_abnormal_immune_serum1.92226570
29MP0002452_abnormal_antigen_presenting1.85641671
30MP0002420_abnormal_adaptive_immunity1.81757187
31MP0001819_abnormal_immune_cell1.81001654
32MP0005319_abnormal_enzyme/_coenzyme1.78587511
33MP0003866_abnormal_defecation1.77632151
34MP0009643_abnormal_urine_homeostasis1.72718266
35MP0002132_abnormal_respiratory_system1.69597982
36MP0005584_abnormal_enzyme/coenzyme_acti1.63686412
37MP0004147_increased_porphyrin_level1.60578670
38MP0000465_gastrointestinal_hemorrhage1.59299341
39MP0002396_abnormal_hematopoietic_system1.55019735
40MP0002166_altered_tumor_susceptibility1.48668246
41MP0005058_abnormal_lysosome_morphology1.47453549
42MP0005451_abnormal_body_composition1.42056908
43MP0002405_respiratory_system_inflammati1.41186253
44MP0003868_abnormal_feces_composition1.41089939
45MP0003763_abnormal_thymus_physiology1.37551411
46MP0000716_abnormal_immune_system1.36979543
47MP0003705_abnormal_hypodermis_morpholog1.34139422
48MP0009333_abnormal_splenocyte_physiolog1.34113775
49MP0003186_abnormal_redox_activity1.33346472
50MP0001764_abnormal_homeostasis1.33268944
51MP0002398_abnormal_bone_marrow1.30676391
52MP0000604_amyloidosis1.29213682
53MP0008260_abnormal_autophagy1.25517274
54MP0009764_decreased_sensitivity_to1.23886255
55MP0002254_reproductive_system_inflammat1.19484283
56MP0005636_abnormal_mineral_homeostasis1.19319481
57MP0001545_abnormal_hematopoietic_system1.18847022
58MP0005397_hematopoietic_system_phenotyp1.18847022
59MP0000689_abnormal_spleen_morphology1.16986659
60MP0000858_altered_metastatic_potential1.15458805
61MP0004883_abnormal_blood_vessel1.14699009
62MP0002722_abnormal_immune_system1.13627736
63MP0002429_abnormal_blood_cell1.10925750
64MP0003828_pulmonary_edema1.10451996
65MP0003690_abnormal_glial_cell1.08960924
66MP0000598_abnormal_liver_morphology1.07567574
67MP0008469_abnormal_protein_level1.06349308
68MP0004043_abnormal_pH_regulation1.05205296
69MP0001756_abnormal_urination1.02052774
70MP0002998_abnormal_bone_remodeling1.01289049
71MP0001851_eye_inflammation1.00144032
72MP0003656_abnormal_erythrocyte_physiolo0.99323030
73MP0002006_tumorigenesis0.98154536
74MP0003300_gastrointestinal_ulcer0.97617116
75MP0002136_abnormal_kidney_physiology0.97353994
76MP0009763_increased_sensitivity_to0.94242531
77MP0005647_abnormal_sex_gland0.93616260
78MP0005167_abnormal_blood-brain_barrier0.89818319
79MP0009642_abnormal_blood_homeostasis0.89207653
80MP0000490_abnormal_crypts_of0.88008809
81MP0001873_stomach_inflammation0.87036670
82MP0003436_decreased_susceptibility_to0.86237762
83MP0006082_CNS_inflammation0.86188416
84MP0002009_preneoplasia0.85795891
85MP0003011_delayed_dark_adaptation0.85776296
86MP0001853_heart_inflammation0.84731214
87MP0009697_abnormal_copulation0.84271228
88MP0009379_abnormal_foot_pigmentation0.84031461
89MP0005408_hypopigmentation0.80421293
90MP0003075_altered_response_to0.79776505
91MP0009278_abnormal_bone_marrow0.77686605
92MP0010234_abnormal_vibrissa_follicle0.76993023
93MP0005084_abnormal_gallbladder_morpholo0.76853550
94MP0005464_abnormal_platelet_physiology0.76788059
95MP0001765_abnormal_ion_homeostasis0.76414283
96MP0003724_increased_susceptibility_to0.76264298
97MP0002277_abnormal_respiratory_mucosa0.75919188
98MP0003329_amyloid_beta_deposits0.75883508
99MP0000703_abnormal_thymus_morphology0.74189709
100MP0005310_abnormal_salivary_gland0.73657730
101MP0004130_abnormal_muscle_cell0.73228686
102MP0005166_decreased_susceptibility_to0.72485075
103MP0005670_abnormal_white_adipose0.72082587
104MP0002971_abnormal_brown_adipose0.71632430
105MP0002078_abnormal_glucose_homeostasis0.70305732
106MP0009765_abnormal_xenobiotic_induced0.69632845
107MP0005376_homeostasis/metabolism_phenot0.68589136
108MP0005535_abnormal_body_temperature0.68362790
109MP0004782_abnormal_surfactant_physiolog0.67371673
110MP0005334_abnormal_fat_pad0.66519850
111MP0010368_abnormal_lymphatic_system0.65692016
112MP0006036_abnormal_mitochondrial_physio0.63423302
113MP0003303_peritoneal_inflammation0.62247028
114MP0002876_abnormal_thyroid_physiology0.61883396
115MP0003638_abnormal_response/metabolism_0.60262528
116MP0003172_abnormal_lysosome_physiology0.59324841
117MP0001845_abnormal_inflammatory_respons0.58665931
118MP0005666_abnormal_adipose_tissue0.58293618
119MP0001661_extended_life_span0.55450269
120MP0002419_abnormal_innate_immunity0.53223163
121MP0004264_abnormal_extraembryonic_tissu0.51561246
122MP0002928_abnormal_bile_duct0.51495442
123MP0000249_abnormal_blood_vessel0.51469752
124MP0005448_abnormal_energy_balance0.48635228
125MP0005220_abnormal_exocrine_pancreas0.48037182
126MP0004947_skin_inflammation0.47396020
127MP0002796_impaired_skin_barrier0.47138968
128MP0000230_abnormal_systemic_arterial0.46963107
129MP0008873_increased_physiological_sensi0.46750308
130MP0008004_abnormal_stomach_pH0.46065780
131MP0002168_other_aberrant_phenotype0.45793371
132MP0008874_decreased_physiological_sensi0.45604455
133MP0005266_abnormal_metabolism0.44644163
134MP0009053_abnormal_anal_canal0.44157014
135MP0005025_abnormal_response_to0.43916859
136MP0005164_abnormal_response_to0.42845204
137MP0009785_altered_susceptibility_to0.42273882
138MP0001881_abnormal_mammary_gland0.42261796
139MP0002135_abnormal_kidney_morphology0.41685016
140MP0001533_abnormal_skeleton_physiology0.41682939
141MP0000538_abnormal_urinary_bladder0.41347011
142MP0010155_abnormal_intestine_physiology0.41274373
143MP0009115_abnormal_fat_cell0.41066917
144MP0009384_cardiac_valve_regurgitation0.40152401
145MP0001663_abnormal_digestive_system0.39819056

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.23681164
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.12962835
3Deep venous thrombosis (HP:0002625)6.09149380
4Xanthomatosis (HP:0000991)5.73792946
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.61040489
6Hypobetalipoproteinemia (HP:0003563)5.21179730
7Eczematoid dermatitis (HP:0000976)5.16753637
8Prolonged partial thromboplastin time (HP:0003645)4.93002307
9Complement deficiency (HP:0004431)4.78180769
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.63892010
11Hyperlipoproteinemia (HP:0010980)4.56497760
12Myositis (HP:0100614)4.53915303
13Recurrent abscess formation (HP:0002722)4.46369869
14Hyperammonemia (HP:0001987)4.25935425
15Recurrent bacterial skin infections (HP:0005406)4.23435403
16Orchitis (HP:0100796)4.18603538
17Hyperglycinuria (HP:0003108)4.14006451
18Joint hemorrhage (HP:0005261)4.10362091
19Ketosis (HP:0001946)4.02555289
20Hypolipoproteinemia (HP:0010981)3.96394399
21Abnormality of macrophages (HP:0004311)3.93348568
22Abnormality of glycine metabolism (HP:0010895)3.90174250
23Abnormality of serine family amino acid metabolism (HP:0010894)3.90174250
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.85860126
25Epidermoid cyst (HP:0200040)3.82146875
26Retrobulbar optic neuritis (HP:0100654)3.81807999
27Optic neuritis (HP:0100653)3.81807999
28Hyperglycinemia (HP:0002154)3.80004232
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.79221810
30Elevated erythrocyte sedimentation rate (HP:0003565)3.73068810
31Fat malabsorption (HP:0002630)3.72880655
32Gastrointestinal infarctions (HP:0005244)3.69095288
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.65022706
34Abnormality of the common coagulation pathway (HP:0010990)3.64073809
35Abnormality of complement system (HP:0005339)3.55060744
36Hypoalphalipoproteinemia (HP:0003233)3.49691700
37Systemic lupus erythematosus (HP:0002725)3.45514772
38Hypoglycemic coma (HP:0001325)3.42772285
39Abnormality of purine metabolism (HP:0004352)3.37253015
40Abnormality of fatty-acid metabolism (HP:0004359)3.34999890
41Conjugated hyperbilirubinemia (HP:0002908)3.30166756
42Gout (HP:0001997)3.29484281
43Hypercholesterolemia (HP:0003124)3.25841471
44Abnormality of nucleobase metabolism (HP:0010932)3.23627679
45Chronic obstructive pulmonary disease (HP:0006510)3.22876018
46Obstructive lung disease (HP:0006536)3.22876018
47Abnormality of methionine metabolism (HP:0010901)3.20734343
48Encephalitis (HP:0002383)3.18898495
49Meningitis (HP:0001287)3.14197331
50Ketoacidosis (HP:0001993)3.11221775
51Abnormal delayed hypersensitivity skin test (HP:0002963)3.11165669
52Stomatitis (HP:0010280)3.08004200
53Recurrent fungal infections (HP:0002841)3.05866777
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04850101
55Vasculitis (HP:0002633)3.00227101
56Recurrent skin infections (HP:0001581)2.98517952
57Abnormality of pyrimidine metabolism (HP:0004353)2.96377007
58Vascular calcification (HP:0004934)2.96300643
59Mediastinal lymphadenopathy (HP:0100721)2.94535449
60Abnormality of the intrinsic pathway (HP:0010989)2.94094519
61Chronic diarrhea (HP:0002028)2.92252726
62Gingivitis (HP:0000230)2.90803297
63Spontaneous hematomas (HP:0007420)2.89334020
64Myocardial infarction (HP:0001658)2.89232917
65Delayed CNS myelination (HP:0002188)2.88695261
66Keratoconjunctivitis sicca (HP:0001097)2.88079641
67Malnutrition (HP:0004395)2.83407334
68Pulmonary embolism (HP:0002204)2.81791447
69Hyperbilirubinemia (HP:0002904)2.79908258
70Epistaxis (HP:0000421)2.78316062
71Metabolic acidosis (HP:0001942)2.76519586
72Prolonged bleeding time (HP:0003010)2.75338592
73Hepatocellular carcinoma (HP:0001402)2.74413169
74Abnormality of proline metabolism (HP:0010907)2.72991718
75Hydroxyprolinuria (HP:0003080)2.72991718
76Glomerulonephritis (HP:0000099)2.72841592
77Pulmonary infiltrates (HP:0002113)2.69466059
78Steatorrhea (HP:0002570)2.67299464
79Urticaria (HP:0001025)2.65703694
80Cardiovascular calcification (HP:0011915)2.64389397
81Keratoconjunctivitis (HP:0001096)2.63804203
82Hemoptysis (HP:0002105)2.63678958
83Recurrent gram-negative bacterial infections (HP:0005420)2.62098165
84Chronic mucocutaneous candidiasis (HP:0002728)2.60151845
85Recurrent cutaneous fungal infections (HP:0011370)2.60151845
86Sensorimotor neuropathy (HP:0007141)2.57912187
87Dicarboxylic aciduria (HP:0003215)2.57021122
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57021122
89Arterial thrombosis (HP:0004420)2.51372873
90Abnormality of serum amino acid levels (HP:0003112)2.51183729
91Chest pain (HP:0100749)2.50143441
92Generalized aminoaciduria (HP:0002909)2.50077602
93Pustule (HP:0200039)2.47714308
94Spastic diplegia (HP:0001264)2.45754923
95Skin nodule (HP:0200036)2.45587101
96Purpura (HP:0000979)2.44227235
97Anorexia (HP:0002039)2.43823378
98Proximal tubulopathy (HP:0000114)2.42043493
99Petechiae (HP:0000967)2.41646681
100Esophageal varix (HP:0002040)2.40602066
101Gangrene (HP:0100758)2.38506494
102Alkalosis (HP:0001948)2.37928087
103Amyloidosis (HP:0011034)2.37816202
104Inflammation of the large intestine (HP:0002037)2.35763917
105Abnormality of T cell number (HP:0011839)2.34069095
106Joint swelling (HP:0001386)2.33576995
107Lethargy (HP:0001254)2.30938411
108Hypochromic anemia (HP:0001931)2.27977298
109Axonal loss (HP:0003447)2.26931006
110Hyperuricemia (HP:0002149)2.26611873
111Increased purine levels (HP:0004368)2.26611873
112T lymphocytopenia (HP:0005403)2.25350052
113Irritability (HP:0000737)2.24615380
114Glycosuria (HP:0003076)2.24596558
115Abnormality of urine glucose concentration (HP:0011016)2.24596558
116Gastrointestinal inflammation (HP:0004386)2.22977320
117Peritonitis (HP:0002586)2.22513072
118Abnormality of T cells (HP:0002843)2.21886131
119Rickets (HP:0002748)2.21569493
120Mitral stenosis (HP:0001718)2.20319180
121Pancreatitis (HP:0001733)2.19442067
122Recurrent viral infections (HP:0004429)2.18677469
123Leukocytosis (HP:0001974)2.18036003
124Increased serum ferritin (HP:0003281)2.17130478
125Vacuolated lymphocytes (HP:0001922)2.16661721
126Granulocytopenia (HP:0001913)2.16558497
127Abnormal enzyme/coenzyme activity (HP:0012379)2.15853537
128Late onset (HP:0003584)2.15010418
129Abnormality of the pleura (HP:0002103)2.14979272
130Abnormality of T cell physiology (HP:0011840)2.14486632
131Spontaneous abortion (HP:0005268)2.14075104
132Vomiting (HP:0002013)2.13680402
133Osteomyelitis (HP:0002754)2.13676991
134Skin rash (HP:0000988)2.12867729
135Acanthocytosis (HP:0001927)2.12788179
136Cellulitis (HP:0100658)2.11447923
137Episodic fever (HP:0001954)2.10976000
138Polycythemia (HP:0001901)2.10765544
139Nephritis (HP:0000123)2.10360515
140Colitis (HP:0002583)2.10074853
141Neonatal onset (HP:0003623)2.06948005
142Abnormality of liposaccharide metabolism (HP:0010968)2.06737713
143Abnormality of glycosphingolipid metabolism (HP:0004343)2.06737713
144Abnormality of glycolipid metabolism (HP:0010969)2.06737713
145Hemorrhage of the eye (HP:0011885)2.04529135
146Widely patent fontanelles and sutures (HP:0004492)2.04087644
147Hypoglycemic seizures (HP:0002173)2.04060356
148Gingival bleeding (HP:0000225)2.02521463
149Cholecystitis (HP:0001082)1.98857896
150Abnormal gallbladder physiology (HP:0012438)1.98857896
151Increased IgE level (HP:0003212)1.98149373
152Menorrhagia (HP:0000132)1.97386311
153Glomerulopathy (HP:0100820)1.96499064
154Abnormal gallbladder morphology (HP:0012437)1.96364482
155Panhypogammaglobulinemia (HP:0003139)1.95642283
156Poikilocytosis (HP:0004447)1.95627511
157Dysostosis multiplex (HP:0000943)1.94954711
158Cholelithiasis (HP:0001081)1.94801927
159Abnormality of alkaline phosphatase activity (HP:0004379)1.94098659
160Abnormality of transition element cation homeostasis (HP:0011030)1.92042565
161Abnormal cartilage morphology (HP:0002763)1.91619220
162Increased IgM level (HP:0003496)1.91314427
163Elevated alkaline phosphatase (HP:0003155)1.90547763
164Nephrolithiasis (HP:0000787)1.90422775
165Hypochromic microcytic anemia (HP:0004840)1.86456874
166Nausea (HP:0002018)1.85842169
167Enlarged kidneys (HP:0000105)1.84821204
168Thrombophlebitis (HP:0004418)1.82390473
169Hypophosphatemic rickets (HP:0004912)1.81945238
170Abnormality of iron homeostasis (HP:0011031)1.79451463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.84265837
2ERN14.15598137
3FGFR43.31653385
4ACVR1B3.18296465
5SIK13.16646352
6MST1R3.02844436
7TAOK32.72848979
8TRIB32.57257827
9TXK2.42514401
10FES2.39980334
11IRAK42.28487957
12EPHB12.16712316
13PKN22.13944608
14PRPF4B1.92254164
15ERBB41.89983908
16TYK21.87158726
17WNK41.83967667
18PTK61.83780795
19FRK1.77070065
20SYK1.75645287
21INSRR1.71533976
22BMPR21.71163741
23GRK61.63803361
24TGFBR21.62987830
25TBK11.58137250
26MATK1.52134209
27MAP3K141.49139792
28HCK1.47424151
29IRAK31.46252929
30FGR1.45543394
31LYN1.44438491
32TEC1.41243651
33PIK3CG1.37830558
34RIPK11.30951043
35NEK91.30751447
36MAPK111.23961717
37JAK11.22175269
38JAK21.21565906
39CAMK1D1.20138373
40YES11.19011198
41MET1.18626519
42OXSR11.18291884
43LCK1.17763460
44ABL21.15638874
45MAP3K101.12716829
46TNK21.12582031
47CSK1.08410407
48MAP3K21.08354573
49MAP2K41.07680647
50TESK21.07271727
51PRKAA21.06451664
52IRAK11.04160242
53MAP3K61.03904888
54DAPK21.03830359
55FGFR21.03202846
56MAP2K31.02816131
57LATS11.00665021
58MAP3K71.00515709
59MAP3K30.99232509
60BLK0.98972661
61FLT30.97123793
62MAP3K120.96857699
63IKBKB0.93467953
64BMX0.91904456
65PDPK10.88975785
66GSK3A0.88954060
67PBK0.88599338
68TAOK10.87256724
69MAP2K20.86466561
70GRK70.85758559
71STK390.84791325
72LMTK20.82327569
73LRRK20.81233886
74MAP3K130.80115468
75IKBKE0.78177967
76MAPK150.77266312
77MAP4K10.76525462
78CDK190.75441340
79PTK20.75348335
80MARK30.73456582
81CAMK1G0.73373787
82MAP3K50.71018246
83MAP3K110.70916906
84WNK30.69567760
85MAP2K60.69302412
86KDR0.69290517
87SGK30.69253748
88PIM10.68898907
89CDK60.68441769
90TIE10.68227459
91KSR20.66182498
92PRKG20.65533721
93MAPK40.65493951
94FYN0.63078197
95PRKCZ0.62287024
96NLK0.61876152
97CSF1R0.61714643
98FGFR30.59916014
99SIK30.59472116
100PDK10.57725532
101IRAK20.57291938
102MAPK120.57046878
103DYRK1B0.56698540
104MAP3K10.55899438
105PINK10.55342981
106TRPM70.55162548
107PRKACG0.54981505
108ERBB20.54340625
109MST40.53015366
110STK38L0.52797073
111PRKCQ0.52316338
112CAMKK20.51570126
113PIK3CA0.49256121
114RET0.48964439
115EPHA30.48899877
116MYLK0.47928876
117ZAP700.47016443
118MAPKAPK20.45983202
119EGFR0.45927124
120MAP2K10.45046283
121SGK2230.44873933
122SGK4940.44873933
123KIT0.44434167
124PRKAA10.44229598
125TAOK20.44014861
126RIPK40.43433350
127PRKCD0.43391318
128BTK0.42179227
129CAMK2G0.41064102
130IGF1R0.40486769
131PDGFRA0.40428063
132JAK30.40327621
133STK100.38468280
134ICK0.38207210
135PDK20.36935382
136ITK0.36843447
137ABL10.36746332
138HIPK20.33237090
139MAPK70.28902575
140RPS6KC10.28786274
141RPS6KL10.28786274
142CDC42BPA0.26131683
143PRKD20.26054651
144RPS6KA60.25596125

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93967150
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.52230735
3Nitrogen metabolism_Homo sapiens_hsa009103.41460973
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93111523
5Arginine biosynthesis_Homo sapiens_hsa002202.71892625
6Tryptophan metabolism_Homo sapiens_hsa003802.65101184
7Fatty acid degradation_Homo sapiens_hsa000712.62921188
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60656363
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50747682
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49259061
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48709222
12Leishmaniasis_Homo sapiens_hsa051402.38469812
13Complement and coagulation cascades_Homo sapiens_hsa046102.38223012
14Butanoate metabolism_Homo sapiens_hsa006502.31119195
15Allograft rejection_Homo sapiens_hsa053302.27516198
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21392670
17Graft-versus-host disease_Homo sapiens_hsa053322.19359260
18Peroxisome_Homo sapiens_hsa041462.13571484
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06612977
20Asthma_Homo sapiens_hsa053102.04857854
21Autoimmune thyroid disease_Homo sapiens_hsa053202.03631301
22Propanoate metabolism_Homo sapiens_hsa006402.00749467
23Histidine metabolism_Homo sapiens_hsa003401.99126683
24PPAR signaling pathway_Homo sapiens_hsa033201.98480273
25Fatty acid metabolism_Homo sapiens_hsa012121.89544680
26Caffeine metabolism_Homo sapiens_hsa002321.81671335
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81617499
28Chemical carcinogenesis_Homo sapiens_hsa052041.80565275
29Staphylococcus aureus infection_Homo sapiens_hsa051501.78297415
30beta-Alanine metabolism_Homo sapiens_hsa004101.77900387
31Osteoclast differentiation_Homo sapiens_hsa043801.72903606
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71507782
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.71198176
34Bile secretion_Homo sapiens_hsa049761.68555673
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.67797123
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66250143
37Sulfur metabolism_Homo sapiens_hsa009201.66187520
38Type I diabetes mellitus_Homo sapiens_hsa049401.59751964
39Retinol metabolism_Homo sapiens_hsa008301.56655789
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.51293104
41Antigen processing and presentation_Homo sapiens_hsa046121.46633670
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45295853
43Tuberculosis_Homo sapiens_hsa051521.45165562
44Starch and sucrose metabolism_Homo sapiens_hsa005001.45079398
45Pyruvate metabolism_Homo sapiens_hsa006201.44368440
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43890694
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40678340
48Fat digestion and absorption_Homo sapiens_hsa049751.39622292
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35081471
50Phenylalanine metabolism_Homo sapiens_hsa003601.34057925
51Hematopoietic cell lineage_Homo sapiens_hsa046401.31040428
52Selenocompound metabolism_Homo sapiens_hsa004501.30711858
53Fatty acid elongation_Homo sapiens_hsa000621.26239403
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.24574039
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24255772
56Vitamin digestion and absorption_Homo sapiens_hsa049771.22937486
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21707007
58ABC transporters_Homo sapiens_hsa020101.19099159
59B cell receptor signaling pathway_Homo sapiens_hsa046621.18030529
60Tyrosine metabolism_Homo sapiens_hsa003501.16060990
61Folate biosynthesis_Homo sapiens_hsa007901.14681920
62Carbon metabolism_Homo sapiens_hsa012001.10365370
63Steroid biosynthesis_Homo sapiens_hsa001001.07911249
64Primary immunodeficiency_Homo sapiens_hsa053401.03689863
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02661836
66Arginine and proline metabolism_Homo sapiens_hsa003301.02179179
67Toxoplasmosis_Homo sapiens_hsa051451.00345616
68Influenza A_Homo sapiens_hsa051640.99349845
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99279853
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.98772471
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.96862701
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92764425
73Biosynthesis of amino acids_Homo sapiens_hsa012300.92740222
74Legionellosis_Homo sapiens_hsa051340.91545355
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.89208697
76Viral myocarditis_Homo sapiens_hsa054160.87093513
77Glutathione metabolism_Homo sapiens_hsa004800.86321546
78Measles_Homo sapiens_hsa051620.85609080
79Glycerolipid metabolism_Homo sapiens_hsa005610.85602641
80Lysine degradation_Homo sapiens_hsa003100.85529081
81Phagosome_Homo sapiens_hsa041450.82895255
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82507017
83Chemokine signaling pathway_Homo sapiens_hsa040620.81150283
84Herpes simplex infection_Homo sapiens_hsa051680.80733719
85Sulfur relay system_Homo sapiens_hsa041220.80412861
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79293234
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78616836
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76616433
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.75329957
90Rheumatoid arthritis_Homo sapiens_hsa053230.75318471
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74436579
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72260605
93TNF signaling pathway_Homo sapiens_hsa046680.70886757
94Acute myeloid leukemia_Homo sapiens_hsa052210.70356823
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69822699
96T cell receptor signaling pathway_Homo sapiens_hsa046600.67525615
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.66219104
98Platelet activation_Homo sapiens_hsa046110.65663939
99Pentose phosphate pathway_Homo sapiens_hsa000300.58424426
100Fatty acid biosynthesis_Homo sapiens_hsa000610.57134951
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56105743
102Vitamin B6 metabolism_Homo sapiens_hsa007500.54211762
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53612440
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49470961
105Hepatitis B_Homo sapiens_hsa051610.42554971
106Salmonella infection_Homo sapiens_hsa051320.42195036
107Ether lipid metabolism_Homo sapiens_hsa005650.42006712
108Galactose metabolism_Homo sapiens_hsa000520.39725037
109Metabolic pathways_Homo sapiens_hsa011000.39049347
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.37683820
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36739672
112Apoptosis_Homo sapiens_hsa042100.35190567
113Fructose and mannose metabolism_Homo sapiens_hsa000510.35055388
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34942466
115Mineral absorption_Homo sapiens_hsa049780.34264693
116Prion diseases_Homo sapiens_hsa050200.32787364
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.32118539
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31857706
119Insulin resistance_Homo sapiens_hsa049310.28756689
120Lysosome_Homo sapiens_hsa041420.28673113
121Renin-angiotensin system_Homo sapiens_hsa046140.28488427
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28251867
123One carbon pool by folate_Homo sapiens_hsa006700.28142738
124Other glycan degradation_Homo sapiens_hsa005110.25087643
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18455988
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.15611088
127Linoleic acid metabolism_Homo sapiens_hsa005910.12861074
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07759358
129Protein digestion and absorption_Homo sapiens_hsa049740.03863611
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02245835
131Thyroid hormone synthesis_Homo sapiens_hsa049180.00166073
132AMPK signaling pathway_Homo sapiens_hsa041520.00075089
133Malaria_Homo sapiens_hsa05144-0.1274579
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1266510
135Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1068344
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0707028
137Amoebiasis_Homo sapiens_hsa05146-0.0686956
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0655764
139African trypanosomiasis_Homo sapiens_hsa05143-0.0618982
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0491775
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0484983
142Glucagon signaling pathway_Homo sapiens_hsa04922-0.0358979
143Hepatitis C_Homo sapiens_hsa05160-0.0239075
144Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0145932
145Pertussis_Homo sapiens_hsa05133-0.0015946

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