HSD17B12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.36865601
2L-phenylalanine catabolic process (GO:0006559)6.36865601
3fatty acid elongation (GO:0030497)6.16820846
4L-phenylalanine metabolic process (GO:0006558)5.95864109
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.95864109
6alpha-linolenic acid metabolic process (GO:0036109)5.81718528
7aromatic amino acid family catabolic process (GO:0009074)5.20830456
8* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.17200900
9* fatty-acyl-CoA biosynthetic process (GO:0046949)5.06287656
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.90664169
11cholesterol biosynthetic process (GO:0006695)4.89312833
12bile acid biosynthetic process (GO:0006699)4.77022768
13glyoxylate metabolic process (GO:0046487)4.66818644
14* thioester biosynthetic process (GO:0035384)4.58685447
15* acyl-CoA biosynthetic process (GO:0071616)4.58685447
16* fatty-acyl-CoA metabolic process (GO:0035337)4.54372786
17very long-chain fatty acid metabolic process (GO:0000038)4.49841864
18* long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.47300567
19sulfur amino acid catabolic process (GO:0000098)4.41077882
20sterol biosynthetic process (GO:0016126)4.34335481
21acetyl-CoA metabolic process (GO:0006084)4.31126719
22plasma lipoprotein particle clearance (GO:0034381)4.31058654
23tryptophan catabolic process (GO:0006569)4.29203475
24indole-containing compound catabolic process (GO:0042436)4.29203475
25indolalkylamine catabolic process (GO:0046218)4.29203475
26coenzyme catabolic process (GO:0009109)4.19578389
27L-serine metabolic process (GO:0006563)4.15555331
28complement activation, alternative pathway (GO:0006957)4.15352435
29aldehyde catabolic process (GO:0046185)4.13316973
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.11859160
31tryptophan metabolic process (GO:0006568)4.09044571
32serine family amino acid biosynthetic process (GO:0009070)4.05823678
33tyrosine metabolic process (GO:0006570)4.04087612
34peptidyl-glutamic acid carboxylation (GO:0017187)4.03146712
35protein carboxylation (GO:0018214)4.03146712
36kynurenine metabolic process (GO:0070189)4.02901459
37* acyl-CoA metabolic process (GO:0006637)4.02540852
38* thioester metabolic process (GO:0035383)4.02540852
39high-density lipoprotein particle remodeling (GO:0034375)3.99156901
40bile acid metabolic process (GO:0008206)3.96435618
41cysteine metabolic process (GO:0006534)3.95161518
42cofactor catabolic process (GO:0051187)3.92102672
43negative regulation of fibrinolysis (GO:0051918)3.90111251
44regulation of triglyceride catabolic process (GO:0010896)3.89433842
45ethanol oxidation (GO:0006069)3.88121078
46regulation of protein activation cascade (GO:2000257)3.86499015
47aromatic amino acid family metabolic process (GO:0009072)3.81140066
48low-density lipoprotein particle clearance (GO:0034383)3.76372095
49urea metabolic process (GO:0019627)3.75120417
50urea cycle (GO:0000050)3.75120417
51regulation of fibrinolysis (GO:0051917)3.68507494
52regulation of complement activation (GO:0030449)3.65752694
53regulation of cholesterol esterification (GO:0010872)3.60267862
54reverse cholesterol transport (GO:0043691)3.59316299
55acylglycerol homeostasis (GO:0055090)3.58910985
56triglyceride homeostasis (GO:0070328)3.58910985
57plasma lipoprotein particle remodeling (GO:0034369)3.58463207
58protein-lipid complex remodeling (GO:0034368)3.58463207
59macromolecular complex remodeling (GO:0034367)3.58463207
60heme transport (GO:0015886)3.57081048
61cellular ketone body metabolic process (GO:0046950)3.55450883
62coenzyme A metabolic process (GO:0015936)3.52855354
63fatty acid beta-oxidation (GO:0006635)3.52292812
64short-chain fatty acid metabolic process (GO:0046459)3.46642532
65alpha-amino acid catabolic process (GO:1901606)3.46209667
66fatty acid catabolic process (GO:0009062)3.45506147
67nitrogen cycle metabolic process (GO:0071941)3.44827094
68regulation of cholesterol metabolic process (GO:0090181)3.43069077
69serine family amino acid metabolic process (GO:0009069)3.40395715
70regulation of cholesterol biosynthetic process (GO:0045540)3.38412766
71cholesterol efflux (GO:0033344)3.34580595
72very-low-density lipoprotein particle assembly (GO:0034379)3.33061571
73fatty acid oxidation (GO:0019395)3.32546375
74amino-acid betaine metabolic process (GO:0006577)3.32193466
75cellular amino acid catabolic process (GO:0009063)3.30226584
76lipid oxidation (GO:0034440)3.28782879
77lysine catabolic process (GO:0006554)3.28726355
78lysine metabolic process (GO:0006553)3.28726355
79homocysteine metabolic process (GO:0050667)3.27064150
80fibrinolysis (GO:0042730)3.25878400
81* triglyceride biosynthetic process (GO:0019432)3.25122428
82monocarboxylic acid catabolic process (GO:0072329)3.24848576
83biotin metabolic process (GO:0006768)3.24649104
84opsonization (GO:0008228)3.24470645
85glycine metabolic process (GO:0006544)3.23188664
86bile acid and bile salt transport (GO:0015721)3.22476424
87linoleic acid metabolic process (GO:0043651)3.20465909
88indolalkylamine metabolic process (GO:0006586)3.19090225
89ketone body metabolic process (GO:1902224)3.18868290
90ethanol metabolic process (GO:0006067)3.18729308
91cholesterol metabolic process (GO:0008203)3.18355627
92cellular glucuronidation (GO:0052695)3.17826910
93organic acid catabolic process (GO:0016054)3.16138350
94carboxylic acid catabolic process (GO:0046395)3.16138350
95* neutral lipid biosynthetic process (GO:0046460)3.15579934
96* acylglycerol biosynthetic process (GO:0046463)3.15579934
97phospholipid efflux (GO:0033700)3.13746691
98cellular aldehyde metabolic process (GO:0006081)3.11618448
99amine catabolic process (GO:0009310)3.10799237
100cellular biogenic amine catabolic process (GO:0042402)3.10799237
101bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65340086
102L-serine transport (GO:0015825)2.60785028
103water-soluble vitamin biosynthetic process (GO:0042364)2.53998961
104sequestering of extracellular ligand from receptor (GO:0035581)2.51882350
105magnesium ion transport (GO:0015693)2.50969994
106hemidesmosome assembly (GO:0031581)2.49657609
107dorsal/ventral axis specification (GO:0009950)2.49165409
108polyketide metabolic process (GO:0030638)2.48958876
109doxorubicin metabolic process (GO:0044598)2.48958876
110daunorubicin metabolic process (GO:0044597)2.48958876
111gap junction assembly (GO:0016264)2.42729423
112anterior/posterior axis specification, embryo (GO:0008595)2.40142294
113paraxial mesoderm development (GO:0048339)2.40133961
114lactate metabolic process (GO:0006089)2.39997922
115aminoglycoside antibiotic metabolic process (GO:0030647)2.38443830
116regulation of cell fate specification (GO:0042659)2.36854563
117cell adhesion mediated by integrin (GO:0033627)2.36737111
118COPII vesicle coating (GO:0048208)2.36298663
119serine family amino acid catabolic process (GO:0009071)2.31453699
120L-ascorbic acid metabolic process (GO:0019852)2.26426234
121auditory receptor cell differentiation (GO:0042491)2.23050879
122establishment of integrated proviral latency (GO:0075713)2.20825896
123inner ear receptor cell development (GO:0060119)2.17752331
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.15906017
125glucuronate metabolic process (GO:0019585)2.15864044
126uronic acid metabolic process (GO:0006063)2.15864044
127C4-dicarboxylate transport (GO:0015740)2.14414669
128response to lipoprotein particle (GO:0055094)2.11785366
129UDP-N-acetylglucosamine metabolic process (GO:0006047)2.11233633
130Sertoli cell development (GO:0060009)2.10382184
131vascular smooth muscle contraction (GO:0014829)2.09813547
132nucleotide-sugar biosynthetic process (GO:0009226)2.06800602
133regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05587040
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.05526810
135branched-chain amino acid catabolic process (GO:0009083)2.05042976
136maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.03662305
137kidney morphogenesis (GO:0060993)2.03233053
138intestinal absorption (GO:0050892)2.01919550
139zinc ion transport (GO:0006829)2.00605145
140isoprenoid biosynthetic process (GO:0008299)2.00246001
141regulation of coenzyme metabolic process (GO:0051196)2.00043570
142regulation of cofactor metabolic process (GO:0051193)2.00043570
143serine transport (GO:0032329)1.99607978
144positive regulation of mitochondrial fission (GO:0090141)1.99476433
145positive regulation of protein autophosphorylation (GO:0031954)1.99464495
146desmosome organization (GO:0002934)1.97153149
147glutamine metabolic process (GO:0006541)1.95759601
148pteridine-containing compound biosynthetic process (GO:0042559)1.95120857
149positive regulation of actin filament depolymerization (GO:0030836)1.94559516
150lipid particle organization (GO:0034389)1.94229176
151negative regulation of hormone metabolic process (GO:0032351)1.94047090
152intestinal cholesterol absorption (GO:0030299)1.93909003
153G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.93775233
154regulation of sulfur metabolic process (GO:0042762)1.92988104
155protein neddylation (GO:0045116)1.92090798
156protein retention in ER lumen (GO:0006621)1.90874277
157glycoside metabolic process (GO:0016137)1.90101084
158cell migration involved in gastrulation (GO:0042074)1.88347969
159transcytosis (GO:0045056)1.87720601
160response to nitrosative stress (GO:0051409)1.87188365
161positive regulation of glycoprotein biosynthetic process (GO:0010560)1.86687458
162blood coagulation, intrinsic pathway (GO:0007597)1.86525615
163L-alpha-amino acid transmembrane transport (GO:1902475)1.86277836
164hair cell differentiation (GO:0035315)1.85814564
165cellular response to cholesterol (GO:0071397)1.85642820
166presynaptic membrane assembly (GO:0097105)1.85240364
167artery smooth muscle contraction (GO:0014824)1.84524063
168CDP-diacylglycerol biosynthetic process (GO:0016024)1.83969333
169regulation of mesoderm development (GO:2000380)1.83956759
170dicarboxylic acid biosynthetic process (GO:0043650)1.83613634
171negative regulation of hormone biosynthetic process (GO:0032353)1.82539648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.61231003
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.92659832
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.53728541
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.70964728
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.50832327
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.99513412
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61620312
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.97607419
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.92638292
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.97989426
11CLOCK_20551151_ChIP-Seq_293T_Human2.61571020
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59882924
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22065110
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21151273
15GBX2_23144817_ChIP-Seq_PC3_Human2.15953763
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15802751
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14156514
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10453276
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.07631267
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04936577
21IGF1R_20145208_ChIP-Seq_DFB_Human2.02454809
22FUS_26573619_Chip-Seq_HEK293_Human2.01649149
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97808852
24* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96651179
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89023407
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87636375
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.85325919
28HTT_18923047_ChIP-ChIP_STHdh_Human1.82178532
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79014125
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71272973
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69617222
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.66458987
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65221457
34P300_19829295_ChIP-Seq_ESCs_Human1.59099786
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54243514
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54064944
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53905448
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.53459324
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52673239
40EWS_26573619_Chip-Seq_HEK293_Human1.52020651
41ELK1_19687146_ChIP-ChIP_HELA_Human1.49680428
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47367050
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.44892083
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43030786
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42363339
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41611767
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41196280
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41196280
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36186643
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.33546352
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32744258
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.32541066
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28560063
54TP53_18474530_ChIP-ChIP_U2OS_Human1.28168706
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27856151
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.27561836
57* NANOG_16153702_ChIP-ChIP_HESCs_Human1.27507762
58ZNF274_21170338_ChIP-Seq_K562_Hela1.27207756
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27132816
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26048400
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24276571
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.23394807
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.21710860
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.21653225
65* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21489818
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20145536
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19741928
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19191209
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18304951
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17963497
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17356659
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17105238
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17028398
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16036512
75CDX2_22108803_ChIP-Seq_LS180_Human1.15010537
76* STAT3_23295773_ChIP-Seq_U87_Human1.14696992
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14674077
78TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14319068
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14225651
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14160641
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.12997314
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12835315
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12193660
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12105851
85TAF15_26573619_Chip-Seq_HEK293_Human1.11208770
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11198357
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10947879
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10922810
89SOX2_20726797_ChIP-Seq_SW620_Human1.10307619
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08649889
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07406267
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07138268
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06760601
94TCF4_22108803_ChIP-Seq_LS180_Human1.06495153
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06121486
96AR_21909140_ChIP-Seq_LNCAP_Human1.05828306
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.05697776
98VDR_22108803_ChIP-Seq_LS180_Human1.05286332
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05071226
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03583376
101CJUN_26792858_Chip-Seq_BT549_Human1.03416477
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03407930
103* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02654948
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01747130
105GATA1_22025678_ChIP-Seq_K562_Human1.01677197
106* P53_22387025_ChIP-Seq_ESCs_Mouse1.01637036
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00626576
108* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00272155
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99947668
110SOX2_18555785_Chip-Seq_ESCs_Mouse0.99654551
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99624278
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99381624
113* MYC_18555785_ChIP-Seq_MESCs_Mouse0.99193842
114SOX17_20123909_ChIP-Seq_XEN_Mouse0.98615798
115* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.98594666
116GATA4_25053715_ChIP-Seq_YYC3_Human0.98588387
117* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97951119
118* STAT3_18555785_Chip-Seq_ESCs_Mouse0.97507522
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.97281947
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97078497
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.96312084
122TP53_16413492_ChIP-PET_HCT116_Human0.95945747
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95632966
124* P300_18555785_Chip-Seq_ESCs_Mouse0.95627449
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.95602664
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95558245
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95451275
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.94464719
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93981677
130HNF4A_19822575_ChIP-Seq_HepG2_Human0.93438106
131JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92521098
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89549923
133WT1_19549856_ChIP-ChIP_CCG9911_Human0.87222321
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86631292
135* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85961384
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85906387
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83465726
138IRF8_22096565_ChIP-ChIP_GC-B_Human0.81448816
139IRF8_21731497_ChIP-ChIP_J774_Mouse0.78379856
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76710146
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75360971
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75308688
143EST1_17652178_ChIP-ChIP_JURKAT_Human0.74634213
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.70327558
145* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69683788
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69280592
147* EOMES_21245162_ChIP-Seq_HESCs_Human0.69210162
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68780506
149AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68420568
150SALL4_22934838_ChIP-ChIP_CD34+_Human0.66106521
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.64979576
152NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.64472243
153* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.64347128
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.63786281
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63566193
156ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62989049
157AR_20517297_ChIP-Seq_VCAP_Human0.60993280
158* CBP_21632823_ChIP-Seq_H3396_Human0.57970980
159SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.57882994
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.57612076
161* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.57558115
162NCOR_22424771_ChIP-Seq_293T_Human0.57553895
163CEBPB_22108803_ChIP-Seq_LS180_Human0.57109579
164PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.56965865
165P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56541929
166CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.56000922
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55269911
168* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.55139069
169CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.55027756
170REST_19997604_ChIP-ChIP_NEURONS_Mouse0.54404066
171DCP1A_22483619_ChIP-Seq_HELA_Human0.54287707
172ERG_20517297_ChIP-Seq_VCAP_Human0.53904036
173* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53291743
174* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.53032198
175FOXA1_25552417_ChIP-Seq_VCAP_Human0.52744517
176SOX2_19829295_ChIP-Seq_ESCs_Human0.52565404
177NANOG_19829295_ChIP-Seq_ESCs_Human0.52565404
178MYC_19915707_ChIP-ChIP_AK7_Human0.52516514

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.18406153
2MP0005360_urolithiasis5.88684397
3MP0003806_abnormal_nucleotide_metabolis4.85274377
4MP0005365_abnormal_bile_salt4.85250485
5MP0005085_abnormal_gallbladder_physiolo4.84321894
6MP0008875_abnormal_xenobiotic_pharmacok3.98099032
7MP0009840_abnormal_foam_cell3.56009041
8MP0010234_abnormal_vibrissa_follicle3.41127667
9MP0010329_abnormal_lipoprotein_level3.22210292
10MP0003941_abnormal_skin_development3.11907785
11MP0003195_calcinosis2.98948479
12MP0005332_abnormal_amino_acid2.53045014
13MP0005083_abnormal_biliary_tract2.50518089
14MP0003191_abnormal_cellular_cholesterol2.47500064
15MP0003252_abnormal_bile_duct2.40686905
16MP0009780_abnormal_chondrocyte_physiolo2.33164553
17MP0003186_abnormal_redox_activity2.30834162
18* MP0003890_abnormal_embryonic-extraembry2.29190862
19MP0002118_abnormal_lipid_homeostasis2.27627921
20MP0003690_abnormal_glial_cell2.26434973
21MP0010352_gastrointestinal_tract_polyps2.24257090
22MP0003122_maternal_imprinting2.22893657
23MP0008438_abnormal_cutaneous_collagen2.20871720
24MP0001666_abnormal_nutrient_absorption2.13129015
25MP0003011_delayed_dark_adaptation2.09246821
26MP0000609_abnormal_liver_physiology1.93034065
27MP0000604_amyloidosis1.89388268
28MP0002938_white_spotting1.85053109
29MP0000566_synostosis1.84717027
30MP0005584_abnormal_enzyme/coenzyme_acti1.82923106
31MP0009697_abnormal_copulation1.81108511
32MP0000920_abnormal_myelination1.73768501
33MP0002837_dystrophic_cardiac_calcinosis1.71569352
34MP0005408_hypopigmentation1.70017486
35MP0005058_abnormal_lysosome_morphology1.69581160
36MP0001764_abnormal_homeostasis1.65436544
37MP0005187_abnormal_penis_morphology1.65142339
38MP0003937_abnormal_limbs/digits/tail_de1.61836956
39MP0005319_abnormal_enzyme/_coenzyme1.59725554
40MP0004019_abnormal_vitamin_homeostasis1.58186191
41MP0003329_amyloid_beta_deposits1.56536326
42MP0006072_abnormal_retinal_apoptosis1.55060994
43MP0010678_abnormal_skin_adnexa1.53966234
44MP0000579_abnormal_nail_morphology1.52554646
45MP0004215_abnormal_myocardial_fiber1.40940203
46MP0003656_abnormal_erythrocyte_physiolo1.38511312
47MP0002233_abnormal_nose_morphology1.37571637
48MP0004133_heterotaxia1.33548122
49MP0002876_abnormal_thyroid_physiology1.32141579
50MP0001293_anophthalmia1.30390607
51MP0000762_abnormal_tongue_morphology1.28513353
52MP0001299_abnormal_eye_distance/1.27680726
53MP0001984_abnormal_olfaction1.27448617
54MP0003119_abnormal_digestive_system1.26953532
55MP0003283_abnormal_digestive_organ1.26512496
56MP0010368_abnormal_lymphatic_system1.25839609
57MP0003950_abnormal_plasma_membrane1.24299415
58MP0001529_abnormal_vocalization1.21705643
59MP0003868_abnormal_feces_composition1.20952439
60MP0005257_abnormal_intraocular_pressure1.19360965
61MP0005670_abnormal_white_adipose1.15539572
62MP0009643_abnormal_urine_homeostasis1.15515576
63MP0003566_abnormal_cell_adhesion1.15464906
64MP0004130_abnormal_muscle_cell1.08594842
65MP0006036_abnormal_mitochondrial_physio1.08536000
66MP0000598_abnormal_liver_morphology1.06441618
67MP0004957_abnormal_blastocyst_morpholog1.05875558
68MP0003705_abnormal_hypodermis_morpholog1.05160679
69MP0005248_abnormal_Harderian_gland1.03962338
70MP0002909_abnormal_adrenal_gland1.03123825
71MP0001661_extended_life_span1.01731085
72MP0003121_genomic_imprinting1.01412403
73MP0005451_abnormal_body_composition1.00987927
74MP0002254_reproductive_system_inflammat0.99849676
75MP0010030_abnormal_orbit_morphology0.99509821
76MP0004185_abnormal_adipocyte_glucose0.98897165
77MP0002796_impaired_skin_barrier0.98000716
78MP0005379_endocrine/exocrine_gland_phen0.97083946
79MP0001881_abnormal_mammary_gland0.96977343
80MP0009763_increased_sensitivity_to0.96579358
81MP0005666_abnormal_adipose_tissue0.94662766
82MP0005376_homeostasis/metabolism_phenot0.94588348
83MP0003136_yellow_coat_color0.94095205
84MP0002971_abnormal_brown_adipose0.93648040
85MP0005253_abnormal_eye_physiology0.93613577
86MP0002084_abnormal_developmental_patter0.92729769
87MP0000537_abnormal_urethra_morphology0.92143698
88MP0000383_abnormal_hair_follicle0.91514529
89MP0002234_abnormal_pharynx_morphology0.91407636
90* MP0008932_abnormal_embryonic_tissue0.90661619
91MP0000778_abnormal_nervous_system0.90351913
92MP0008775_abnormal_heart_ventricle0.90119250
93MP0002697_abnormal_eye_size0.89685954
94MP0005275_abnormal_skin_tensile0.88587387
95MP0008469_abnormal_protein_level0.87648181
96MP0009765_abnormal_xenobiotic_induced0.87072263
97MP0003755_abnormal_palate_morphology0.85809082
98MP0000462_abnormal_digestive_system0.85293788
99MP0004084_abnormal_cardiac_muscle0.84087581
100MP0002295_abnormal_pulmonary_circulatio0.83130194
101MP0003315_abnormal_perineum_morphology0.82902361
102MP0003632_abnormal_nervous_system0.82863550
103MP0005334_abnormal_fat_pad0.82359735
104MP0005171_absent_coat_pigmentation0.81941670
105MP0003724_increased_susceptibility_to0.81023001
106MP0001286_abnormal_eye_development0.80933182
107MP0004147_increased_porphyrin_level0.80200615
108MP0008789_abnormal_olfactory_epithelium0.80142153
109MP0005164_abnormal_response_to0.79590032
110MP0006082_CNS_inflammation0.79582933
111MP0002111_abnormal_tail_morphology0.77205374
112MP0005535_abnormal_body_temperature0.76141281
113MP0005499_abnormal_olfactory_system0.75650019
114MP0005394_taste/olfaction_phenotype0.75650019
115MP0005551_abnormal_eye_electrophysiolog0.75393115
116MP0009764_decreased_sensitivity_to0.74550163
117MP0000428_abnormal_craniofacial_morphol0.74197806
118MP0004381_abnormal_hair_follicle0.74070484
119MP0004134_abnormal_chest_morphology0.74001180
120MP0005266_abnormal_metabolism0.73742099
121MP0003718_maternal_effect0.73197748
122MP0000647_abnormal_sebaceous_gland0.71978543
123MP0001188_hyperpigmentation0.71421098
124MP0001243_abnormal_dermal_layer0.71267666
125MP0009672_abnormal_birth_weight0.71205666
126MP0005636_abnormal_mineral_homeostasis0.70578551
127MP0009642_abnormal_blood_homeostasis0.70340250
128MP0005647_abnormal_sex_gland0.69849036
129MP0002078_abnormal_glucose_homeostasis0.69640236
130MP0002090_abnormal_vision0.69486126
131MP0009384_cardiac_valve_regurgitation0.67711309
132MP0009250_abnormal_appendicular_skeleto0.67166768
133MP0004782_abnormal_surfactant_physiolog0.67125706
134MP0003634_abnormal_glial_cell0.66132759
135MP0001324_abnormal_eye_pigmentation0.65967719
136MP0003567_abnormal_fetal_cardiomyocyte0.65932196
137MP0001915_intracranial_hemorrhage0.65738137
138MP0005391_vision/eye_phenotype0.65715355
139MP0002970_abnormal_white_adipose0.65129048
140MP0005195_abnormal_posterior_eye0.64669478
141MP0000631_abnormal_neuroendocrine_gland0.64663231
142MP0004885_abnormal_endolymph0.64426177
143MP0003942_abnormal_urinary_system0.63524255
144MP0000432_abnormal_head_morphology0.62355678
145MP0003172_abnormal_lysosome_physiology0.61880335
146MP0009046_muscle_twitch0.61630608
147MP0003787_abnormal_imprinting0.61253698
148MP0002896_abnormal_bone_mineralization0.61057466
149MP0008873_increased_physiological_sensi0.61045313
150MP0004270_analgesia0.60997448
151MP0000427_abnormal_hair_cycle0.60568254
152MP0000639_abnormal_adrenal_gland0.60429014
153MP0003075_altered_response_to0.60174636
154MP0008260_abnormal_autophagy0.58464130
155MP0001542_abnormal_bone_strength0.57637146
156MP0005448_abnormal_energy_balance0.56244555
157MP0005220_abnormal_exocrine_pancreas0.54580190
158MP0006035_abnormal_mitochondrial_morpho0.53513257
159MP0002060_abnormal_skin_morphology0.53301017
160MP0003959_abnormal_lean_body0.53192054
161MP0001905_abnormal_dopamine_level0.53167622
162MP0005375_adipose_tissue_phenotype0.52611869
163MP0002138_abnormal_hepatobiliary_system0.51876859
164MP0000372_irregular_coat_pigmentation0.51439616
165MP0001756_abnormal_urination0.51006890
166MP0001533_abnormal_skeleton_physiology0.50859193
167MP0005395_other_phenotype0.49530126
168MP0006054_spinal_hemorrhage0.47135330
169MP0004272_abnormal_basement_membrane0.46750932
170MP0001177_atelectasis0.46728810
171MP0002419_abnormal_innate_immunity0.45169863

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.82144664
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.73665548
3Xanthomatosis (HP:0000991)5.32106760
4Deep venous thrombosis (HP:0002625)5.15548942
5Hypobetalipoproteinemia (HP:0003563)4.86541769
6Prolonged partial thromboplastin time (HP:0003645)4.68733467
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.58998711
8Hyperlipoproteinemia (HP:0010980)4.48560785
9Complement deficiency (HP:0004431)4.30650178
10Abnormality of glycolysis (HP:0004366)3.97365514
11Increased serum pyruvate (HP:0003542)3.97365514
12Hyperammonemia (HP:0001987)3.90355877
13Epidermoid cyst (HP:0200040)3.88655505
14Abnormality of serine family amino acid metabolism (HP:0010894)3.85240799
15Abnormality of glycine metabolism (HP:0010895)3.85240799
16Hyperglycinemia (HP:0002154)3.74495003
17Hypolipoproteinemia (HP:0010981)3.57899117
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49189213
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.48799831
20Ketosis (HP:0001946)3.41779171
21Abnormality of fatty-acid metabolism (HP:0004359)3.37606831
22Hypoglycemic coma (HP:0001325)3.37207853
23Abnormality of methionine metabolism (HP:0010901)3.37131987
24Fat malabsorption (HP:0002630)3.34697649
25Abnormality of complement system (HP:0005339)3.23885279
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.23386353
27Hyperglycinuria (HP:0003108)3.21299799
28Abnormality of the common coagulation pathway (HP:0010990)3.18071381
29Joint hemorrhage (HP:0005261)3.10786677
30Spastic paraparesis (HP:0002313)3.05739273
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.00451844
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99275172
33Hyperinsulinemic hypoglycemia (HP:0000825)2.98180686
34Hypoalphalipoproteinemia (HP:0003233)2.93533717
35Abnormality of serum amino acid levels (HP:0003112)2.93155334
36Abnormality of the intrinsic pathway (HP:0010989)2.92097429
37Steatorrhea (HP:0002570)2.88702591
38Neurofibrillary tangles (HP:0002185)2.84815629
39Conjugated hyperbilirubinemia (HP:0002908)2.79935848
40Hypercholesterolemia (HP:0003124)2.73435804
41Parakeratosis (HP:0001036)2.72819539
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67076586
43Dicarboxylic aciduria (HP:0003215)2.67076586
44Cerebral edema (HP:0002181)2.65431402
45Systemic lupus erythematosus (HP:0002725)2.64614780
46Ketoacidosis (HP:0001993)2.62269735
47Lethargy (HP:0001254)2.59354016
48Proximal tubulopathy (HP:0000114)2.53512413
49Coronal craniosynostosis (HP:0004440)2.53335076
50Opisthotonus (HP:0002179)2.53037563
51Spastic diplegia (HP:0001264)2.50002844
52Abnormal gallbladder physiology (HP:0012438)2.47366175
53Cholecystitis (HP:0001082)2.47366175
54Skin nodule (HP:0200036)2.46177387
55Right ventricular cardiomyopathy (HP:0011663)2.43214119
56Hepatoblastoma (HP:0002884)2.40543365
57Intestinal atresia (HP:0011100)2.38849130
58Brushfield spots (HP:0001088)2.38687175
59Hyperbilirubinemia (HP:0002904)2.36333194
60Abnormality of pyrimidine metabolism (HP:0004353)2.35927405
61Colon cancer (HP:0003003)2.34433136
62Symptomatic seizures (HP:0011145)2.34338379
63Hepatic necrosis (HP:0002605)2.32373201
64Paraparesis (HP:0002385)2.31722009
65Epiphyseal stippling (HP:0010655)2.31569302
66Myocardial infarction (HP:0001658)2.30145028
67Delayed CNS myelination (HP:0002188)2.26480920
68Acute encephalopathy (HP:0006846)2.25431897
69Cerebral inclusion bodies (HP:0100314)2.22162797
70Amyloidosis (HP:0011034)2.20972211
71Generalized aminoaciduria (HP:0002909)2.19910471
72Cortical dysplasia (HP:0002539)2.16900338
73Metabolic acidosis (HP:0001942)2.15713931
74Irritability (HP:0000737)2.13065183
75Abnormal gallbladder morphology (HP:0012437)2.11216237
76Sensorimotor neuropathy (HP:0007141)2.10488811
77Congenital ichthyosiform erythroderma (HP:0007431)2.10305157
78Hepatosplenomegaly (HP:0001433)2.09576286
79Degeneration of the lateral corticospinal tracts (HP:0002314)2.09445970
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09445970
81Abnormality of nucleobase metabolism (HP:0010932)2.09241168
82Axonal loss (HP:0003447)2.08785218
83Vomiting (HP:0002013)2.08698980
84Cardiovascular calcification (HP:0011915)2.06743557
85Exercise-induced muscle cramps (HP:0003710)2.03874146
86Abnormal biliary tract morphology (HP:0012440)2.03313697
87Papillary thyroid carcinoma (HP:0002895)2.03007777
88Hypoglycemic seizures (HP:0002173)2.00423364
89Pterygium (HP:0001059)1.99627708
90Cerebral hemorrhage (HP:0001342)1.97288725
91Hepatocellular carcinoma (HP:0001402)1.96358812
92Abnormality of purine metabolism (HP:0004352)1.95898050
93Hyperglycemia (HP:0003074)1.95698304
94Hypertriglyceridemia (HP:0002155)1.95058633
95Methylmalonic aciduria (HP:0012120)1.93971436
96Gastrointestinal atresia (HP:0002589)1.93932102
97Fragile nails (HP:0001808)1.92474765
98Pancreatitis (HP:0001733)1.91765373
99Abnormal cartilage morphology (HP:0002763)1.91618172
100Double outlet right ventricle (HP:0001719)1.91228269
101Congenital malformation of the right heart (HP:0011723)1.91228269
102Labial hypoplasia (HP:0000066)1.89412978
103Spontaneous abortion (HP:0005268)1.88607471
104Recurrent gram-negative bacterial infections (HP:0005420)1.87723070
105Methylmalonic acidemia (HP:0002912)1.85993138
106Abnormality of urine glucose concentration (HP:0011016)1.85465316
107Glycosuria (HP:0003076)1.85465316
108Hepatocellular necrosis (HP:0001404)1.83675217
109Vascular calcification (HP:0004934)1.83566157
110Mitral stenosis (HP:0001718)1.83548854
111Hypophosphatemic rickets (HP:0004912)1.82795617
112CNS demyelination (HP:0007305)1.81020271
113Genital tract atresia (HP:0001827)1.80150241
114Abnormality of the gallbladder (HP:0005264)1.79986063
115Cholelithiasis (HP:0001081)1.78929194
116Vaginal atresia (HP:0000148)1.77701065
117Hypoplastic female external genitalia (HP:0012815)1.77259297
118Ileus (HP:0002595)1.77215465
119Renal cortical cysts (HP:0000803)1.76652538
120Leukodystrophy (HP:0002415)1.76557260
121Esophageal atresia (HP:0002032)1.76353289
122Abnormality of iron homeostasis (HP:0011031)1.75567323
123Bifid tongue (HP:0010297)1.75396060
124Thyroid carcinoma (HP:0002890)1.75383156
125Glomerulonephritis (HP:0000099)1.74734139
1263-Methylglutaconic aciduria (HP:0003535)1.74659835
127Aplasia/Hypoplasia of the hallux (HP:0008362)1.73912274
128Adrenal hypoplasia (HP:0000835)1.73629244
129Acanthocytosis (HP:0001927)1.72264820
130Scrotal hypoplasia (HP:0000046)1.72072230
131Myelomeningocele (HP:0002475)1.70978674
132Back pain (HP:0003418)1.70369935
133Abnormality of vitamin metabolism (HP:0100508)1.67445748
134Short tibia (HP:0005736)1.66037616
135Neoplasm of the adrenal gland (HP:0100631)1.64683721
136Disproportionate short-trunk short stature (HP:0003521)1.62791730
137Abnormality of the antihelix (HP:0009738)1.60064209
138Pancreatic islet-cell hyperplasia (HP:0004510)1.57187695
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56991772
140Abnormality of alanine metabolism (HP:0010916)1.56991772
141Hyperalaninemia (HP:0003348)1.56991772
142Anophthalmia (HP:0000528)1.54362303
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.52829829
144Preaxial foot polydactyly (HP:0001841)1.52184429
145Stenosis of the external auditory canal (HP:0000402)1.50849996
146Hemiparesis (HP:0001269)1.50648489
147Congenital primary aphakia (HP:0007707)1.50590395
148Medial flaring of the eyebrow (HP:0010747)1.49964103
149Rhabdomyosarcoma (HP:0002859)1.49438196
150Aplasia involving bones of the extremities (HP:0009825)1.49334866
151Aplasia involving bones of the upper limbs (HP:0009823)1.49334866
152Aplasia of the phalanges of the hand (HP:0009802)1.49334866
153Poor suck (HP:0002033)1.48771393
154Broad alveolar ridges (HP:0000187)1.47888996
155True hermaphroditism (HP:0010459)1.47853675
156Short hallux (HP:0010109)1.45693184
157Onycholysis (HP:0001806)1.45337114
158Hypokinesia (HP:0002375)1.45162935
159Abnormality of the middle phalanges of the toes (HP:0010183)1.45137201
160Biliary tract neoplasm (HP:0100574)1.44899263
161Absent eyelashes (HP:0000561)1.43496755
162Pancreatic fibrosis (HP:0100732)1.43332580
163Absent eyebrow (HP:0002223)1.42949759
164Tetraparesis (HP:0002273)1.42914699
165Medulloblastoma (HP:0002885)1.41889635
166Uterine neoplasm (HP:0010784)1.41214852
167Abnormality of vitamin B metabolism (HP:0004340)1.41185454
168Microglossia (HP:0000171)1.41013466
169Palpitations (HP:0001962)1.41008847
170Plantar hyperkeratosis (HP:0007556)1.40993367
171Gait imbalance (HP:0002141)1.39756467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.82460367
2PBK4.47510948
3STK393.49373996
4ERBB43.33658039
5EPHB13.25560843
6SIK12.85148622
7MET2.69069562
8OXSR12.59847879
9WNK32.35221164
10MST1R2.20025733
11ERN12.15536961
12LATS12.07152855
13PNCK2.04055978
14MAPKAPK52.01345620
15TESK22.00979089
16FLT31.98662609
17LIMK11.97957071
18BCR1.96950385
19EIF2AK31.87513205
20STK31.61570674
21NUAK11.61088261
22STK241.60453154
23STK161.59732730
24TTK1.53853586
25TAF11.52977096
26MAP3K91.50870365
27STK38L1.49292602
28ABL21.47872089
29ARAF1.46940880
30FGFR41.46849126
31EIF2AK11.46158694
32ERBB31.45889006
33EPHB21.44925259
34PLK31.40277609
35CAMK1D1.34851404
36FGFR21.33919842
37NTRK11.27054990
38CSNK1G31.27043825
39MAP3K121.25731754
40PLK41.23128130
41MKNK21.22262697
42INSRR1.19917932
43NEK11.14334021
44ZAK1.13718369
45TBK11.13434321
46PIM21.12981161
47PKN11.11014402
48PKN21.10681834
49IRAK31.08000027
50MST41.04060692
51MKNK11.04022206
52TIE11.03352838
53CASK1.02707335
54LATS21.00337663
55MAP3K41.00167838
56LMTK20.98277902
57WNK40.97716259
58GRK10.96480341
59CSNK1G10.94235275
60TRIM280.93809303
61TRIB30.92794674
62EPHA20.89637174
63BRAF0.89253021
64DMPK0.89166749
65NEK90.89028539
66PTK20.88076635
67GSK3A0.88025868
68CSF1R0.87821299
69TYK20.86158552
70BLK0.85427977
71TSSK60.84458516
72PRKCE0.83385128
73FER0.83226548
74PINK10.82154530
75PIK3CG0.82029217
76SRPK10.79201145
77WEE10.77506863
78SCYL20.76634634
79PDGFRA0.74230752
80DYRK20.73382380
81MAP3K30.73195368
82PLK10.72396228
83BMPR1B0.70818472
84CSNK1A1L0.70525179
85DDR20.69245337
86PRKCG0.68906570
87VRK10.68651743
88BRSK20.68362249
89PDK40.67691006
90PDK30.67691006
91TGFBR10.66890527
92MAP2K70.66458492
93FRK0.66355233
94EIF2AK20.65293247
95FGR0.63862207
96KIT0.63574665
97MAP3K140.62927741
98TNIK0.60811723
99MAP2K10.60784009
100IGF1R0.60675412
101CAMK2G0.59436605
102FGFR10.59093689
103CSNK1G20.58340385
104CSNK1E0.57979092
105PHKG20.56460497
106PHKG10.56460497
107CDC70.55759082
108CDK190.55386024
109MYLK0.54704427
110TESK10.53910565
111MAPK110.53485055
112MAPK40.53483716
113PRKG20.49672895
114ROCK20.48917099
115EPHA40.48115175
116CDK140.48024123
117PRKACG0.47850645
118CSNK1A10.47370056
119BMX0.47020597
120PDK20.46875272
121BUB10.46586181
122PAK20.46083141
123NME20.45570129
124SGK4940.44903659
125SGK2230.44903659
126LRRK20.44481655
127JAK20.44434323
128PTK60.43314135
129CDK30.42668040
130ATM0.42585990
131CAMK2A0.40282778
132PIK3CA0.39743818
133MINK10.39600856
134AKT30.38523946
135UHMK10.37934679
136ADRBK20.37865509
137PAK30.37451135
138MAP4K20.37371392
139EGFR0.37166460
140PRKAA20.36522243
141ACVR1B0.35387142
142CAMK2B0.35332834
143PRKCD0.34309228
144LYN0.34105379
145PRKCZ0.32671490
146CAMK1G0.32077309
147MAP2K40.32031835
148ERBB20.31605602
149MAP2K30.31456231
150CAMK2D0.30289401
151PAK40.30199669
152PLK20.29829365

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.43518722
2* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.38644170
3Steroid biosynthesis_Homo sapiens_hsa001003.14603748
4* Fatty acid elongation_Homo sapiens_hsa000622.88601590
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65246172
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62739468
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57852826
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48179195
9Fatty acid degradation_Homo sapiens_hsa000712.45586473
10Propanoate metabolism_Homo sapiens_hsa006402.44073817
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39651808
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37321461
13* Fatty acid metabolism_Homo sapiens_hsa012122.37303237
14Nitrogen metabolism_Homo sapiens_hsa009102.32182829
15Butanoate metabolism_Homo sapiens_hsa006502.28370343
16Peroxisome_Homo sapiens_hsa041462.18820795
17Tryptophan metabolism_Homo sapiens_hsa003802.15420386
18Arginine biosynthesis_Homo sapiens_hsa002202.02216791
19Complement and coagulation cascades_Homo sapiens_hsa046101.98620230
20Histidine metabolism_Homo sapiens_hsa003401.95716546
21PPAR signaling pathway_Homo sapiens_hsa033201.94676601
22Caffeine metabolism_Homo sapiens_hsa002321.81290415
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80572035
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79484077
25Sulfur metabolism_Homo sapiens_hsa009201.79057110
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77128162
27Pyruvate metabolism_Homo sapiens_hsa006201.76571137
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65830836
29beta-Alanine metabolism_Homo sapiens_hsa004101.65253218
30Chemical carcinogenesis_Homo sapiens_hsa052041.59869412
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58629540
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54531472
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.47084102
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45721513
35Vitamin B6 metabolism_Homo sapiens_hsa007501.45562298
36Fatty acid biosynthesis_Homo sapiens_hsa000611.44529716
37Retinol metabolism_Homo sapiens_hsa008301.43697924
38Tyrosine metabolism_Homo sapiens_hsa003501.41736927
39Phenylalanine metabolism_Homo sapiens_hsa003601.40644399
40Carbon metabolism_Homo sapiens_hsa012001.37747283
41* Steroid hormone biosynthesis_Homo sapiens_hsa001401.34325993
42Staphylococcus aureus infection_Homo sapiens_hsa051501.33129632
43Folate biosynthesis_Homo sapiens_hsa007901.33074857
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29733767
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27829833
46Biosynthesis of amino acids_Homo sapiens_hsa012301.26199222
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24679755
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21140794
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.15349159
50Selenocompound metabolism_Homo sapiens_hsa004501.15169922
51Fat digestion and absorption_Homo sapiens_hsa049751.09498567
52Glutathione metabolism_Homo sapiens_hsa004801.02231623
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99965268
54Arginine and proline metabolism_Homo sapiens_hsa003300.94971191
55Starch and sucrose metabolism_Homo sapiens_hsa005000.89191513
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87495226
57Sulfur relay system_Homo sapiens_hsa041220.85480444
58Pentose phosphate pathway_Homo sapiens_hsa000300.84653347
59Protein export_Homo sapiens_hsa030600.84004913
60Bile secretion_Homo sapiens_hsa049760.83555592
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79791247
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79265367
63ECM-receptor interaction_Homo sapiens_hsa045120.77513045
64Proteasome_Homo sapiens_hsa030500.75803155
65Hippo signaling pathway_Homo sapiens_hsa043900.75464685
66Glycerolipid metabolism_Homo sapiens_hsa005610.74114136
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73428224
68Renin-angiotensin system_Homo sapiens_hsa046140.72908636
69One carbon pool by folate_Homo sapiens_hsa006700.71212846
70Basal cell carcinoma_Homo sapiens_hsa052170.67734742
71* Metabolic pathways_Homo sapiens_hsa011000.66936693
72Mismatch repair_Homo sapiens_hsa034300.62769841
73ABC transporters_Homo sapiens_hsa020100.61616533
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59570737
75Thyroid hormone synthesis_Homo sapiens_hsa049180.57638896
76Ether lipid metabolism_Homo sapiens_hsa005650.56665474
77Non-homologous end-joining_Homo sapiens_hsa034500.56573118
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56077779
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.55778964
80Mineral absorption_Homo sapiens_hsa049780.55527760
81Tight junction_Homo sapiens_hsa045300.53182000
82Adherens junction_Homo sapiens_hsa045200.52906807
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52239489
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51736469
85Hedgehog signaling pathway_Homo sapiens_hsa043400.49780009
86TGF-beta signaling pathway_Homo sapiens_hsa043500.47397691
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.47212219
88Basal transcription factors_Homo sapiens_hsa030220.47086551
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45073135
90Protein digestion and absorption_Homo sapiens_hsa049740.44966177
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43459273
92Oxidative phosphorylation_Homo sapiens_hsa001900.42778263
93Circadian rhythm_Homo sapiens_hsa047100.42643552
94Linoleic acid metabolism_Homo sapiens_hsa005910.41775915
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41749084
96Collecting duct acid secretion_Homo sapiens_hsa049660.41321668
97Prion diseases_Homo sapiens_hsa050200.41045347
98Insulin secretion_Homo sapiens_hsa049110.38824865
99Lysosome_Homo sapiens_hsa041420.37770595
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32497540
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31884158
102Galactose metabolism_Homo sapiens_hsa000520.26840327
103Phagosome_Homo sapiens_hsa041450.25128761
104Sphingolipid metabolism_Homo sapiens_hsa006000.23650412
105Fructose and mannose metabolism_Homo sapiens_hsa000510.20056967
106Parkinsons disease_Homo sapiens_hsa050120.19705915
107Arachidonic acid metabolism_Homo sapiens_hsa005900.19130032
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.16452157
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.15733905
110Lysine degradation_Homo sapiens_hsa003100.14604631
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.14407133
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12754037
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12417491
114N-Glycan biosynthesis_Homo sapiens_hsa005100.08175307
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06851327
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05185007
117Vibrio cholerae infection_Homo sapiens_hsa051100.04875363
118Rheumatoid arthritis_Homo sapiens_hsa053230.02814651
119Alzheimers disease_Homo sapiens_hsa050100.02012008
120Legionellosis_Homo sapiens_hsa051340.01286460
121Hepatitis C_Homo sapiens_hsa05160-0.0467237
122SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0433332
123Pertussis_Homo sapiens_hsa05133-0.0406732
124Malaria_Homo sapiens_hsa05144-0.0243380

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