ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	estrogen biosynthetic process (GO:0006703)	9.56489058
2	cellular response to ATP (GO:0071318)	7.92729133
3	protein carboxylation (GO:0018214)	7.28917867
4	peptidyl-glutamic acid carboxylation (GO:0017187)	7.28917867
5	GDP-mannose metabolic process (GO:0019673)	7.21448798
6	regulation of skeletal muscle contraction (GO:0014819)	7.11317158
7	adenosine receptor signaling pathway (GO:0001973)	6.83406805
8	negative regulation of cell aging (GO:0090344)	6.82650106
9	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	6.61227813
10	DNA strand renaturation (GO:0000733)	6.23004272
11	negative regulation of interleukin-8 production (GO:0032717)	6.13219327
12	regulation of synapse structural plasticity (GO:0051823)	5.87010560
13	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	5.80469939
14	mannose metabolic process (GO:0006013)	5.62744695
15	mitotic cell cycle arrest (GO:0071850)	5.46422273
16	proline biosynthetic process (GO:0006561)	5.30937251
17	purinergic nucleotide receptor signaling pathway (GO:0035590)	5.21223018
18	positive regulation of protein kinase C signaling (GO:0090037)	5.10970342
19	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.04858606
20	lens fiber cell differentiation (GO:0070306)	5.02422715
21	meiotic chromosome segregation (GO:0045132)	4.84142607
22	adenine nucleotide transport (GO:0051503)	4.78778228
23	purine ribonucleotide transport (GO:0015868)	4.65859428
24	granulocyte differentiation (GO:0030851)	4.58736967
25	transepithelial transport (GO:0070633)	4.52658526
26	response to ATP (GO:0033198)	4.42433717
27	detection of light stimulus involved in sensory perception (GO:0050962)	4.31984946
28	detection of light stimulus involved in visual perception (GO:0050908)	4.31984946
29	purinergic receptor signaling pathway (GO:0035587)	4.14491796
30	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.98155510
31	estrogen metabolic process (GO:0008210)	3.96994447
32	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.92966619
33	semaphorin-plexin signaling pathway (GO:0071526)	3.92690000
34	proline metabolic process (GO:0006560)	3.90609189
35	sphingosine metabolic process (GO:0006670)	3.90583396
36	androgen biosynthetic process (GO:0006702)	3.83377982
37	sphingomyelin metabolic process (GO:0006684)	3.80212878
38	purine nucleotide transport (GO:0015865)	3.76985527
39	sensory perception of taste (GO:0050909)	3.72042371
40	negative regulation of erythrocyte differentiation (GO:0045647)	3.68941742
41	UV protection (GO:0009650)	3.58958397
42	diol metabolic process (GO:0034311)	3.48717476
43	positive regulation of heat generation (GO:0031652)	3.46016499
44	rRNA methylation (GO:0031167)	3.43734465
45	folic acid transport (GO:0015884)	3.43070216
46	folic acid metabolic process (GO:0046655)	3.39637874
47	type B pancreatic cell proliferation (GO:0044342)	3.35970254
48	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.33576532
49	negative regulation of toll-like receptor signaling pathway (GO:0034122)	3.31615525
50	sialylation (GO:0097503)	3.30958674
51	endocytic recycling (GO:0032456)	3.29652777
52	nucleoside transmembrane transport (GO:1901642)	3.20567652
53	peptidyl-glutamic acid modification (GO:0018200)	3.20166718
54	phosphate ion homeostasis (GO:0055062)	3.16878716
55	trivalent inorganic anion homeostasis (GO:0072506)	3.16878716
56	regulation of cell aging (GO:0090342)	3.14186607
57	response to peptidoglycan (GO:0032494)	3.12148381
58	sphingoid metabolic process (GO:0046519)	3.10419024
59	phosphatidylglycerol biosynthetic process (GO:0006655)	3.08874535
60	regulation of phospholipid biosynthetic process (GO:0071071)	3.08503691
61	protein insertion into membrane (GO:0051205)	3.07481761
62	nucleotide-sugar biosynthetic process (GO:0009226)	3.03672273
63	sulfur amino acid catabolic process (GO:0000098)	3.02200941
64	mitochondrion distribution (GO:0048311)	2.95714633
65	glycine transport (GO:0015816)	2.94496342
66	negative regulation of tumor necrosis factor production (GO:0032720)	2.91773134
67	melanin biosynthetic process (GO:0042438)	2.89199636
68	sex determination (GO:0007530)	2.87902353
69	modulation by virus of host process (GO:0019054)	2.85352311
70	germinal center formation (GO:0002467)	2.83856247
71	urinary tract smooth muscle contraction (GO:0014848)	2.83490127
72	cellular anion homeostasis (GO:0030002)	2.83316332
73	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	2.82502415
74	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.80923190
75	nucleoside transport (GO:0015858)	2.77349297
76	histone phosphorylation (GO:0016572)	2.75970964
77	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.75132428
78	grooming behavior (GO:0007625)	2.74856956
79	melanin metabolic process (GO:0006582)	2.74158207
80	regulation of interferon-beta biosynthetic process (GO:0045357)	2.74049750
81	keratan sulfate metabolic process (GO:0042339)	2.73381800
82	response to muramyl dipeptide (GO:0032495)	2.70958681
83	cardiolipin metabolic process (GO:0032048)	2.65316944
84	oligosaccharide catabolic process (GO:0009313)	2.64829163
85	protein import into peroxisome matrix (GO:0016558)	2.63266266
86	female pregnancy (GO:0007565)	2.61763427
87	regulation of type I interferon-mediated signaling pathway (GO:0060338)	2.61731390
88	renal absorption (GO:0070293)	2.58549904
89	cell migration in hindbrain (GO:0021535)	2.58505902
90	regulation of cholesterol homeostasis (GO:2000188)	2.57711158
91	regulation of ARF GTPase activity (GO:0032312)	2.57158690
92	regulation of protein kinase A signaling (GO:0010738)	2.56213237
93	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.54955164
94	keratan sulfate biosynthetic process (GO:0018146)	2.54549245
95	peristalsis (GO:0030432)	2.54470876
96	pinocytosis (GO:0006907)	2.54116890
97	glycosphingolipid catabolic process (GO:0046479)	2.52481766
98	androgen metabolic process (GO:0008209)	2.50219182
99	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.48843089
100	rRNA modification (GO:0000154)	2.47810378

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	4.43018694
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.58264179
3	LXR_22292898_ChIP-Seq_THP-1_Human	3.17602367
4	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.00342576
5	P68_20966046_ChIP-Seq_HELA_Human	2.80422181
6	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.53657859
7	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.52918528
8	VDR_24763502_ChIP-Seq_THP-1_Human	2.41637676
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.34916111
10	MAF_26560356_Chip-Seq_TH2_Human	2.34313197
11	MYC_22102868_ChIP-Seq_BL_Human	2.29279028
12	RACK7_27058665_Chip-Seq_MCF-7_Human	2.28317844
13	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.27527650
14	CTCF_27219007_Chip-Seq_ERYTHROID_Human	2.23986250
15	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.17833097
16	BCOR_27268052_Chip-Seq_Bcells_Human	2.12702351
17	BCL6_27268052_Chip-Seq_Bcells_Human	2.11640344
18	MAF_26560356_Chip-Seq_TH1_Human	2.09214845
19	E2F1_20622854_ChIP-Seq_HELA_Human	2.05875824
20	KDM2B_26808549_Chip-Seq_DND41_Human	2.05157310
21	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.03236165
22	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.96208768
23	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.92968403
24	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.90872430
25	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.89469363
26	TCF7_22412390_ChIP-Seq_EML_Mouse	1.89208027
27	XRN2_22483619_ChIP-Seq_HELA_Human	1.87055953
28	CTCF_27219007_Chip-Seq_Bcells_Human	1.86602910
29	SMC4_20622854_ChIP-Seq_HELA_Human	1.86018438
30	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.85603224
31	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.81705233
32	PHF8_20622854_ChIP-Seq_HELA_Human	1.81585478
33	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.78974247
34	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.77167831
35	UTX_26944678_Chip-Seq_JUKART_Human	1.72601290
36	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.71044986
37	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.67134681
38	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.66091019
39	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.66009084
40	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.64417532
41	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.64205360
42	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.63615427
43	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.57281103
44	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.56993202
45	CTCF_21964334_Chip-Seq_Bcells_Human	1.56137328
46	CREB1_26743006_Chip-Seq_LNCaP_Human	1.55398881
47	TP53_22127205_ChIP-Seq_IMR90_Human	1.49419031
48	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.46899944
49	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.44855944
50	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.44151600
51	CTCF_20526341_ChIP-Seq_ESCs_Human	1.44091381
52	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43089178
53	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.40540875
54	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.40167090
55	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.39896776
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.37988614
57	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.36368636
58	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.35327522
59	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.35111604
60	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.34680727
61	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.31599067
62	NCOR1_26117541_ChIP-Seq_K562_Human	1.30595288
63	KDM2B_26808549_Chip-Seq_K562_Human	1.30479421
64	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.29716090
65	SA1_27219007_Chip-Seq_Bcells_Human	1.28965534
66	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28160880
67	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.27477591
68	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.25279603
69	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.25013409
70	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.22660160
71	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.21828309
72	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.20227601
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19107174
74	TP63_22573176_ChIP-Seq_HFKS_Human	1.17753746
75	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.17626799
76	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.17352110
77	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.17037882
78	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.16024982
79	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15625812
80	ATF3_27146783_Chip-Seq_COLON_Human	1.15416638
81	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.15215550
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.14399233
83	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.13622198
84	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.12814992
85	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12545897
86	SCL_19346495_ChIP-Seq_HPC-7_Human	1.11874265
87	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.11837426
88	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.10831846
89	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.09437046
90	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.08582450
91	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.07973947
92	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.07590084
93	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07343758
94	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.06591062
95	P300_27268052_Chip-Seq_Bcells_Human	1.04878580
96	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.01652634
97	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.00018239
98	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.99800579
99	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98687299
100	ERA_21632823_ChIP-Seq_H3396_Human	0.97629248

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	6.14711869
2	MP0001986_abnormal_taste_sensitivity	5.53108129
3	MP0005174_abnormal_tail_pigmentation	4.64541103
4	MP0005423_abnormal_somatic_nervous	4.09943346
5	MP0003136_yellow_coat_color	3.97512165
6	MP0002254_reproductive_system_inflammat	3.78852091
7	MP0003303_peritoneal_inflammation	3.65024639
8	MP0005409_darkened_coat_color	3.33140768
9	MP0000751_myopathy	2.67563345
10	MP0001348_abnormal_lacrimal_gland	2.54272380
11	MP0003878_abnormal_ear_physiology	2.46949054
12	MP0005377_hearing/vestibular/ear_phenot	2.46949054
13	MP0001661_extended_life_span	2.35674514
14	MP0005083_abnormal_biliary_tract	2.21279136
15	MP0008875_abnormal_xenobiotic_pharmacok	2.17674479
16	MP0001188_hyperpigmentation	2.06614180
17	MP0005058_abnormal_lysosome_morphology	2.04308225
18	MP0001968_abnormal_touch/_nociception	2.04106807
19	MP0003705_abnormal_hypodermis_morpholog	2.01556300
20	MP0003453_abnormal_keratinocyte_physiol	1.93691859
21	MP0005451_abnormal_body_composition	1.89834002
22	MP0004381_abnormal_hair_follicle	1.88377490
23	MP0005330_cardiomyopathy	1.84011039
24	MP0000015_abnormal_ear_pigmentation	1.81120107
25	MP0001756_abnormal_urination	1.73158233
26	MP0001958_emphysema	1.72906049
27	MP0003172_abnormal_lysosome_physiology	1.71362666
28	MP0004130_abnormal_muscle_cell	1.68589987
29	MP0002160_abnormal_reproductive_system	1.67937870
30	MP0005076_abnormal_cell_differentiation	1.65004138
31	MP0001873_stomach_inflammation	1.64416277
32	MP0000750_abnormal_muscle_regeneration	1.56709737
33	MP0000013_abnormal_adipose_tissue	1.48088170
34	MP0001765_abnormal_ion_homeostasis	1.43679097
35	MP0005365_abnormal_bile_salt	1.37156423
36	MP0001346_abnormal_lacrimal_gland	1.34667184
37	MP0001502_abnormal_circadian_rhythm	1.33535660
38	MP0000003_abnormal_adipose_tissue	1.28777483
39	MP0000747_muscle_weakness	1.24315407
40	MP0005410_abnormal_fertilization	1.22915136
41	MP0004185_abnormal_adipocyte_glucose	1.21445212
42	MP0000470_abnormal_stomach_morphology	1.19864590
43	MP0002876_abnormal_thyroid_physiology	1.18197089
44	MP0004019_abnormal_vitamin_homeostasis	1.16494938
45	MP0001919_abnormal_reproductive_system	1.16364254
46	MP0006082_CNS_inflammation	1.09963325
47	MP0005257_abnormal_intraocular_pressure	1.09265991
48	MP0004858_abnormal_nervous_system	0.96566623
49	MP0005332_abnormal_amino_acid	0.95905558
50	MP0000538_abnormal_urinary_bladder	0.94548727
51	MP0005584_abnormal_enzyme/coenzyme_acti	0.88805814
52	MP0005389_reproductive_system_phenotype	0.86572797
53	MP0003329_amyloid_beta_deposits	0.85638539
54	MP0009643_abnormal_urine_homeostasis	0.85330422
55	MP0009278_abnormal_bone_marrow	0.85318877
56	MP0001664_abnormal_digestion	0.84799893
57	MP0005501_abnormal_skin_physiology	0.83951785
58	MP0000685_abnormal_immune_system	0.83740312
59	MP0004043_abnormal_pH_regulation	0.83240715
60	MP0005647_abnormal_sex_gland	0.82975286
61	MP0003111_abnormal_nucleus_morphology	0.82597272
62	MP0002736_abnormal_nociception_after	0.82185565
63	MP0003091_abnormal_cell_migration	0.80665689
64	MP0004947_skin_inflammation	0.78997812
65	MP0003436_decreased_susceptibility_to	0.78904131
66	MP0001851_eye_inflammation	0.77536829
67	MP0009840_abnormal_foam_cell	0.76890636
68	MP0002735_abnormal_chemical_nociception	0.76816856
69	MP0003448_altered_tumor_morphology	0.76379752
70	MP0005375_adipose_tissue_phenotype	0.75446811
71	MP0002638_abnormal_pupillary_reflex	0.74451700
72	MP0000367_abnormal_coat/_hair	0.73871199
73	MP0009697_abnormal_copulation	0.73743373
74	MP0002075_abnormal_coat/hair_pigmentati	0.71208533
75	MP0005023_abnormal_wound_healing	0.70072456
76	MP0005666_abnormal_adipose_tissue	0.65673548
77	MP0000358_abnormal_cell_content/	0.64767361
78	MP0003763_abnormal_thymus_physiology	0.63581982
79	MP0000858_altered_metastatic_potential	0.61223888
80	MP0002998_abnormal_bone_remodeling	0.60609689
81	MP0002136_abnormal_kidney_physiology	0.58703471
82	MP0010368_abnormal_lymphatic_system	0.58046223
83	MP0009931_abnormal_skin_appearance	0.57764768
84	MP0010329_abnormal_lipoprotein_level	0.54889715
85	MP0004782_abnormal_surfactant_physiolog	0.54618910
86	MP0008874_decreased_physiological_sensi	0.53454824
87	MP0004087_abnormal_muscle_fiber	0.52298632
88	MP0002118_abnormal_lipid_homeostasis	0.52231890
89	MP0003656_abnormal_erythrocyte_physiolo	0.52228593
90	MP0010155_abnormal_intestine_physiology	0.52126493
91	MP0002419_abnormal_innate_immunity	0.51538525
92	MP0002019_abnormal_tumor_incidence	0.50575917
93	MP0002060_abnormal_skin_morphology	0.49934256
94	MP0003806_abnormal_nucleotide_metabolis	0.49930321
95	MP0001905_abnormal_dopamine_level	0.49447034
96	MP0010771_integument_phenotype	0.49205173
97	MP0002933_joint_inflammation	0.48970462
98	MP0002909_abnormal_adrenal_gland	0.48784756
99	MP0005167_abnormal_blood-brain_barrier	0.48730581
100	MP0003183_abnormal_peptide_metabolism	0.45861522

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	6.44388441
2	Ulnar bowing (HP:0003031)	5.47749459
3	Rib fusion (HP:0000902)	5.38923505
4	Hemorrhage of the eye (HP:0011885)	5.09838803
5	Annular pancreas (HP:0001734)	4.85770272
6	Dyschromatopsia (HP:0007641)	4.79853655
7	Mesangial abnormality (HP:0001966)	4.74220834
8	Thin bony cortex (HP:0002753)	4.62786942
9	Joint hemorrhage (HP:0005261)	4.59174974
10	Turricephaly (HP:0000262)	4.37231468
11	Attenuation of retinal blood vessels (HP:0007843)	4.19388349
12	Facial hemangioma (HP:0000329)	4.15227448
13	Rectovaginal fistula (HP:0000143)	4.12839120
14	Rectal fistula (HP:0100590)	4.12839120
15	Akinesia (HP:0002304)	4.09842095
16	Abnormality of the intrinsic pathway (HP:0010989)	4.04832574
17	Vaginal fistula (HP:0004320)	4.04430682
18	Poikiloderma (HP:0001029)	4.02148019
19	Popliteal pterygium (HP:0009756)	4.00725145
20	Intestinal fistula (HP:0100819)	3.97631493
21	Prolonged partial thromboplastin time (HP:0003645)	3.96152318
22	Facial diplegia (HP:0001349)	3.91686709
23	Aplasia of the musculature (HP:0100854)	3.57893205
24	Choroideremia (HP:0001139)	3.40935565
25	Atrioventricular block (HP:0001678)	3.31877084
26	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.27503681
27	Capillary hemangiomas (HP:0005306)	3.23810002
28	Coronal craniosynostosis (HP:0004440)	3.22131509
29	Anteriorly placed anus (HP:0001545)	3.11940574
30	Increased circulating renin level (HP:0000848)	3.06945990
31	Fetal akinesia sequence (HP:0001989)	3.06393036
32	Congenital stationary night blindness (HP:0007642)	3.05163254
33	Squamous cell carcinoma (HP:0002860)	3.04988845
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.96061682
35	Bowed forearm bones (HP:0003956)	2.95839777
36	Bowing of the arm (HP:0006488)	2.95839777
37	Abnormality of the common coagulation pathway (HP:0010990)	2.92150187
38	Joint stiffness (HP:0001387)	2.89623227
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.87302556
40	Increased hepatocellular lipid droplets (HP:0006565)	2.79794014
41	Abnormal drinking behavior (HP:0030082)	2.77707039
42	Polydipsia (HP:0001959)	2.77707039
43	Renal Fanconi syndrome (HP:0001994)	2.75775357
44	Long clavicles (HP:0000890)	2.74931396
45	Abnormality of the costochondral junction (HP:0000919)	2.72878536
46	Neonatal respiratory distress (HP:0002643)	2.70206514
47	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.69836914
48	Abnormality of polysaccharide metabolism (HP:0011012)	2.69836914
49	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.69836914
50	Delayed epiphyseal ossification (HP:0002663)	2.69797121
51	Lipid accumulation in hepatocytes (HP:0006561)	2.62830584
52	Short chin (HP:0000331)	2.62827300
53	Myotonia (HP:0002486)	2.61718129
54	Decreased central vision (HP:0007663)	2.61605569
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.59654404
56	Hypoalbuminemia (HP:0003073)	2.55380125
57	Abnormal albumin level (HP:0012116)	2.55380125
58	Thin ribs (HP:0000883)	2.51311249
59	Neonatal onset (HP:0003623)	2.48234052
60	Mucopolysacchariduria (HP:0008155)	2.42479669
61	Urinary glycosaminoglycan excretion (HP:0003541)	2.42479669
62	Hypophosphatemic rickets (HP:0004912)	2.37795298
63	Widely patent fontanelles and sutures (HP:0004492)	2.37140661
64	Abnormality of placental membranes (HP:0011409)	2.36108928
65	Amniotic constriction ring (HP:0009775)	2.36108928
66	Myopathic facies (HP:0002058)	2.32274789
67	Enlarged epiphyses (HP:0010580)	2.31441084
68	Pustule (HP:0200039)	2.31363602
69	Zonular cataract (HP:0010920)	2.28930870
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.28539256
71	Chorioretinal atrophy (HP:0000533)	2.25661197
72	Increased muscle lipid content (HP:0009058)	2.21936006
73	Heart block (HP:0012722)	2.19333141
74	Patellar aplasia (HP:0006443)	2.16816310
75	Increased intramyocellular lipid droplets (HP:0012240)	2.16529288
76	Bilateral sensorineural hearing impairment (HP:0008619)	2.15702183
77	Basal cell carcinoma (HP:0002671)	2.15360204
78	Abnormal atrioventricular conduction (HP:0005150)	2.14008435
79	Choanal stenosis (HP:0000452)	2.10770660
80	Flat occiput (HP:0005469)	2.10056797
81	Diminished movement (HP:0002374)	2.08480682
82	Cholelithiasis (HP:0001081)	2.05838829
83	Cheilitis (HP:0100825)	2.04887169
84	Renal tubular dysfunction (HP:0000124)	2.04703063
85	Chronic mucocutaneous candidiasis (HP:0002728)	2.03453375
86	Recurrent cutaneous fungal infections (HP:0011370)	2.03453375
87	Short humerus (HP:0005792)	2.03326707
88	Aplasia/Hypoplasia of the patella (HP:0006498)	2.00601347
89	Narrow nasal bridge (HP:0000446)	1.99860726
90	Increased number of teeth (HP:0011069)	1.99274251
91	Malignant hyperthermia (HP:0002047)	1.97825418
92	Respiratory difficulties (HP:0002880)	1.95726565
93	Premature graying of hair (HP:0002216)	1.94493983
94	Abnormal epiphyseal ossification (HP:0010656)	1.93478717
95	Pterygium (HP:0001059)	1.90119748
96	Polyuria (HP:0000103)	1.86259536
97	Hypokalemic alkalosis (HP:0001949)	1.85342872
98	Tetany (HP:0001281)	1.82257672
99	Easy fatigability (HP:0003388)	1.80987877
100	Exertional dyspnea (HP:0002875)	1.80898814

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	8.42856917
2	MAPK15	6.00544935
3	STK39	5.34104475
4	OXSR1	3.74908837
5	TESK2	3.10453189
6	ERN1	2.97549702
7	TRIB3	2.45790932
8	MAP2K3	2.31602701
9	BLK	2.26911767
10	SIK1	1.69571252
11	MUSK	1.69134408
12	ZAP70	1.59727553
13	ICK	1.52577193
14	GRK6	1.46949493
15	SMG1	1.40701161
16	STK16	1.27342523
17	MAP4K1	1.26990528
18	SIK2	1.26375914
19	EEF2K	1.26280244
20	PDPK1	1.23534600
21	PRPF4B	1.16156542
22	PRKD3	1.11481791
23	TLK1	1.05239990
24	MAP3K6	1.03790744
25	MAP2K6	0.98487781
26	CSK	0.97116154
27	PRKD2	0.96998434
28	TBK1	0.93610316
29	CDK12	0.87411470
30	WNK1	0.87298021
31	BMX	0.84974411
32	DAPK2	0.84112334
33	CDK6	0.80251779
34	DYRK1B	0.78658008
35	CDK4	0.74243674
36	PKN2	0.72424570
37	MAP2K4	0.72314934
38	MAP3K11	0.69211572
39	ADRBK1	0.65119960
40	PDGFRA	0.64432639
41	CDK15	0.63523329
42	KDR	0.60836722
43	CDK11A	0.59767735
44	MTOR	0.59586252
45	RPS6KA2	0.59408396
46	TNK2	0.58275389
47	LATS1	0.56998623
48	IRAK2	0.56162701
49	CDK18	0.55854610
50	MARK2	0.55306025
51	RPS6KL1	0.54544566
52	RPS6KC1	0.54544566
53	FGFR4	0.54148651
54	PRKD1	0.54118929
55	RIPK4	0.53529130
56	RPS6KA6	0.53127611
57	MAPK11	0.51769994
58	FES	0.49991695
59	ARAF	0.48498440
60	MAP3K1	0.45877461
61	KSR2	0.45414476
62	SIK3	0.44353156
63	NEK9	0.41458249
64	PAK1	0.39728066
65	AKT3	0.38850868
66	TTN	0.38757866
67	PRKG2	0.38134055
68	PTK6	0.38017514
69	MAPK12	0.37696689
70	PDK1	0.37645865
71	CDK14	0.37597534
72	HIPK2	0.36800777
73	SYK	0.35843818
74	CCNB1	0.35092032
75	IRAK3	0.35077828
76	MAP3K7	0.34341332
77	HCK	0.34245929
78	RIPK1	0.34217215
79	BTK	0.33238584
80	MAPK8	0.32435391
81	MAP3K14	0.31430861
82	MELK	0.28231959
83	PRKAA1	0.27903644
84	PIM2	0.27883566
85	CDC42BPA	0.27877972
86	RET	0.27134253
87	EPHA2	0.26633171
88	MAP3K3	0.25759823
89	AURKA	0.25315418
90	ADRBK2	0.25197333
91	LYN	0.24864159
92	TGFBR2	0.24398282
93	STK11	0.23700934
94	PRKCH	0.23592940
95	JAK3	0.23506454
96	SRC	0.21453774
97	IKBKB	0.21240790
98	DAPK1	0.20895395
99	MAP2K1	0.20639600
100	MAPK3	0.20055189

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	6.62730462
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.81680071
3	Sulfur relay system_Homo sapiens_hsa04122	3.88101970
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.85141389
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.50096219
6	Other glycan degradation_Homo sapiens_hsa00511	2.97069710
7	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.66569016
8	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.45478200
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.41683144
10	Sphingolipid metabolism_Homo sapiens_hsa00600	2.29424045
11	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.92248896
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.67265749
13	Lysosome_Homo sapiens_hsa04142	1.64149520
14	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.35379311
15	VEGF signaling pathway_Homo sapiens_hsa04370	1.22937985
16	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.19899151
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18787509
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13964722
19	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.12822618
20	mTOR signaling pathway_Homo sapiens_hsa04150	1.09015764
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05752852
22	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00364309
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.96909544
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94639755
25	Bladder cancer_Homo sapiens_hsa05219	0.92095915
26	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.90624758
27	Acute myeloid leukemia_Homo sapiens_hsa05221	0.90284415
28	Notch signaling pathway_Homo sapiens_hsa04330	0.85134936
29	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.82552639
30	Endocytosis_Homo sapiens_hsa04144	0.81652981
31	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.79427087
32	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.77889153
33	Primary immunodeficiency_Homo sapiens_hsa05340	0.74658666
34	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.74374885
35	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.72854296
36	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.71305065
37	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.71066951
38	Insulin resistance_Homo sapiens_hsa04931	0.69699058
39	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.67594416
40	Tuberculosis_Homo sapiens_hsa05152	0.67107485
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.66921164
42	Circadian rhythm_Homo sapiens_hsa04710	0.62975821
43	Hepatitis C_Homo sapiens_hsa05160	0.61786941
44	Non-small cell lung cancer_Homo sapiens_hsa05223	0.60517643
45	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.59959929
46	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.58201039
47	Calcium signaling pathway_Homo sapiens_hsa04020	0.57826474
48	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56551534
49	Lysine degradation_Homo sapiens_hsa00310	0.55590512
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54413658
51	Taste transduction_Homo sapiens_hsa04742	0.53777489
52	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.52811073
53	Arginine biosynthesis_Homo sapiens_hsa00220	0.51844065
54	Osteoclast differentiation_Homo sapiens_hsa04380	0.49816427
55	MAPK signaling pathway_Homo sapiens_hsa04010	0.49212105
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49031871
57	Melanogenesis_Homo sapiens_hsa04916	0.48685683
58	Pancreatic cancer_Homo sapiens_hsa05212	0.48649570
59	Insulin signaling pathway_Homo sapiens_hsa04910	0.46771436
60	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.44107692
61	Phenylalanine metabolism_Homo sapiens_hsa00360	0.43882292
62	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.43237910
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.42633128
64	GnRH signaling pathway_Homo sapiens_hsa04912	0.42275811
65	Influenza A_Homo sapiens_hsa05164	0.41941425
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41274176
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40222649
68	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.39395942
69	Platelet activation_Homo sapiens_hsa04611	0.38012247
70	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.37601364
71	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.37567274
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37417343
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36540822
74	Galactose metabolism_Homo sapiens_hsa00052	0.36049709
75	TNF signaling pathway_Homo sapiens_hsa04668	0.35792385
76	ABC transporters_Homo sapiens_hsa02010	0.35508916
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.35304258
78	Toxoplasmosis_Homo sapiens_hsa05145	0.35024314
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34224487
80	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31134699
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29435687
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29166522
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.28864736
84	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28482899
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28255997
86	Endometrial cancer_Homo sapiens_hsa05213	0.28228120
87	Fanconi anemia pathway_Homo sapiens_hsa03460	0.25906278
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.25171529
89	Cocaine addiction_Homo sapiens_hsa05030	0.24574540
90	Choline metabolism in cancer_Homo sapiens_hsa05231	0.24274471
91	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.23502036
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.23197785
93	Herpes simplex infection_Homo sapiens_hsa05168	0.22681206
94	Leishmaniasis_Homo sapiens_hsa05140	0.21359107
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.21318616
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.20233147
97	Apoptosis_Homo sapiens_hsa04210	0.20002334
98	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.19763419
99	Hepatitis B_Homo sapiens_hsa05161	0.19183027
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.19148604

HSD17B1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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