HSD17B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.36328305
2L-phenylalanine catabolic process (GO:0006559)7.36328305
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.04226685
4L-phenylalanine metabolic process (GO:0006558)7.04226685
5aromatic amino acid family catabolic process (GO:0009074)6.64881856
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.32721387
7indole-containing compound catabolic process (GO:0042436)6.03784723
8indolalkylamine catabolic process (GO:0046218)6.03784723
9tryptophan catabolic process (GO:0006569)6.03784723
10kynurenine metabolic process (GO:0070189)5.92931710
11bile acid biosynthetic process (GO:0006699)5.86973874
12glyoxylate metabolic process (GO:0046487)5.79238421
13negative regulation of fibrinolysis (GO:0051918)5.70004287
14tryptophan metabolic process (GO:0006568)5.67928404
15high-density lipoprotein particle remodeling (GO:0034375)5.65457953
16epoxygenase P450 pathway (GO:0019373)5.65056337
17sulfur amino acid catabolic process (GO:0000098)5.60280755
18urea metabolic process (GO:0019627)5.51626815
19urea cycle (GO:0000050)5.51626815
20regulation of fibrinolysis (GO:0051917)5.49608953
21regulation of protein activation cascade (GO:2000257)5.37651351
22complement activation, alternative pathway (GO:0006957)5.34761364
23alpha-linolenic acid metabolic process (GO:0036109)5.33090696
24exogenous drug catabolic process (GO:0042738)5.32894916
25cysteine metabolic process (GO:0006534)5.31573349
26protein carboxylation (GO:0018214)5.31000451
27peptidyl-glutamic acid carboxylation (GO:0017187)5.31000451
28nitrogen cycle metabolic process (GO:0071941)5.06636107
29bile acid metabolic process (GO:0008206)5.03908321
30regulation of complement activation (GO:0030449)5.02629150
31reverse cholesterol transport (GO:0043691)4.99964973
32serine family amino acid catabolic process (GO:0009071)4.98966915
33regulation of triglyceride catabolic process (GO:0010896)4.85596929
34regulation of cholesterol esterification (GO:0010872)4.85224039
35protein-lipid complex remodeling (GO:0034368)4.83572152
36macromolecular complex remodeling (GO:0034367)4.83572152
37plasma lipoprotein particle remodeling (GO:0034369)4.83572152
38aromatic amino acid family metabolic process (GO:0009072)4.82778059
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79302197
40bile acid and bile salt transport (GO:0015721)4.76473765
41homocysteine metabolic process (GO:0050667)4.71605165
42cellular ketone body metabolic process (GO:0046950)4.65995076
43drug metabolic process (GO:0017144)4.65525134
44triglyceride homeostasis (GO:0070328)4.65042574
45acylglycerol homeostasis (GO:0055090)4.65042574
46phospholipid efflux (GO:0033700)4.64651870
47tyrosine metabolic process (GO:0006570)4.63102874
48negative regulation of sterol transport (GO:0032372)4.58042325
49negative regulation of cholesterol transport (GO:0032375)4.58042325
50lysine catabolic process (GO:0006554)4.51241908
51lysine metabolic process (GO:0006553)4.51241908
52alpha-amino acid catabolic process (GO:1901606)4.50955223
53amino-acid betaine metabolic process (GO:0006577)4.50100670
54plasma lipoprotein particle clearance (GO:0034381)4.45027064
55cellular glucuronidation (GO:0052695)4.35558699
56glycine metabolic process (GO:0006544)4.28810584
57indolalkylamine metabolic process (GO:0006586)4.27467282
58omega-hydroxylase P450 pathway (GO:0097267)4.25468723
59coenzyme catabolic process (GO:0009109)4.24567840
60cholesterol efflux (GO:0033344)4.24106488
61imidazole-containing compound metabolic process (GO:0052803)4.21689384
62cellular amino acid catabolic process (GO:0009063)4.19296828
63cellular biogenic amine catabolic process (GO:0042402)4.16767433
64amine catabolic process (GO:0009310)4.16767433
65glutamate metabolic process (GO:0006536)4.12429728
66oxidative demethylation (GO:0070989)4.10448178
67plasma lipoprotein particle assembly (GO:0034377)4.08700060
68serine family amino acid metabolic process (GO:0009069)4.08250807
69benzene-containing compound metabolic process (GO:0042537)4.06637816
70ethanol oxidation (GO:0006069)4.06420373
71fibrinolysis (GO:0042730)4.04684214
72ketone body metabolic process (GO:1902224)4.03693998
73drug catabolic process (GO:0042737)3.99764709
74cellular modified amino acid catabolic process (GO:0042219)3.99572854
75serine family amino acid biosynthetic process (GO:0009070)3.95107865
76low-density lipoprotein particle remodeling (GO:0034374)3.95047438
77arginine metabolic process (GO:0006525)3.94952394
78aldehyde catabolic process (GO:0046185)3.94286175
79alkaloid metabolic process (GO:0009820)3.91604739
80blood coagulation, intrinsic pathway (GO:0007597)3.90993627
81phospholipid homeostasis (GO:0055091)3.90406425
82positive regulation of lipoprotein lipase activity (GO:0051006)3.89704884
83positive regulation of triglyceride lipase activity (GO:0061365)3.89704884
84dicarboxylic acid biosynthetic process (GO:0043650)3.89666603
85uronic acid metabolic process (GO:0006063)3.86696041
86glucuronate metabolic process (GO:0019585)3.86696041
87cholesterol homeostasis (GO:0042632)3.83326874
88sterol homeostasis (GO:0055092)3.77020410
89intestinal absorption (GO:0050892)3.75893241
90complement activation, classical pathway (GO:0006958)3.75618403
91flavonoid metabolic process (GO:0009812)3.75578197
92very-low-density lipoprotein particle assembly (GO:0034379)3.73995453
93protein activation cascade (GO:0072376)3.73689444
94regulation of bile acid biosynthetic process (GO:0070857)3.73320381
95cytolysis (GO:0019835)3.72723998
96complement activation (GO:0006956)3.70136760
97regulation of cholesterol homeostasis (GO:2000188)3.69787341
98cofactor catabolic process (GO:0051187)3.69754214
99positive regulation of lipid catabolic process (GO:0050996)3.69093004
100plasma lipoprotein particle organization (GO:0071827)3.68776232
101protein-lipid complex assembly (GO:0065005)3.67454006
102organic acid catabolic process (GO:0016054)3.66860182
103carboxylic acid catabolic process (GO:0046395)3.66860182
104short-chain fatty acid metabolic process (GO:0046459)3.65947457
105regulation of guanylate cyclase activity (GO:0031282)3.63624445
106negative regulation of lipase activity (GO:0060192)3.63490372
107L-fucose catabolic process (GO:0042355)3.59385489
108fucose catabolic process (GO:0019317)3.59385489
109L-fucose metabolic process (GO:0042354)3.59385489
110sulfation (GO:0051923)3.56739622
111acetyl-CoA metabolic process (GO:0006084)3.54545959
112NAD biosynthetic process (GO:0009435)3.52163174
113phenylpropanoid metabolic process (GO:0009698)3.50204339
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32656862
115fat-soluble vitamin biosynthetic process (GO:0042362)3.26407839
1163-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.21320258
117purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.21320258
118drug transmembrane transport (GO:0006855)3.12329931
119regulation of lipoprotein metabolic process (GO:0050746)3.09005865
120positive regulation of guanylate cyclase activity (GO:0031284)3.05772863
121positive regulation of fatty acid transport (GO:2000193)3.05118473
122vitamin biosynthetic process (GO:0009110)3.03473977
123transepithelial transport (GO:0070633)3.02769149
124urate metabolic process (GO:0046415)3.02624644
125angiotensin maturation (GO:0002003)3.02002077
126positive regulation of icosanoid secretion (GO:0032305)2.97432013
127sulfate transmembrane transport (GO:1902358)2.95978153
128negative regulation of protein activation cascade (GO:2000258)2.94259083
129regulation of protein glycosylation (GO:0060049)2.94047936
130behavioral response to nicotine (GO:0035095)2.91711135
131intestinal cholesterol absorption (GO:0030299)2.89625808
132detection of light stimulus involved in visual perception (GO:0050908)2.88534834
133detection of light stimulus involved in sensory perception (GO:0050962)2.88534834
134indole-containing compound metabolic process (GO:0042430)2.88002989
135xenobiotic catabolic process (GO:0042178)2.87883251
136heme transport (GO:0015886)2.84909723
137S-adenosylmethionine metabolic process (GO:0046500)2.83755274
138arginine catabolic process (GO:0006527)2.83172945
139reflex (GO:0060004)2.80891107
140water-soluble vitamin biosynthetic process (GO:0042364)2.80540116
141xenobiotic metabolic process (GO:0006805)2.79657767
142ethanol metabolic process (GO:0006067)2.79257134
143regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.76645474
144drug transport (GO:0015893)2.70180669
145quinone biosynthetic process (GO:1901663)2.69429292
146lipoprotein metabolic process (GO:0042157)2.68700712
147negative regulation of complement activation (GO:0045916)2.66350615
148behavioral response to ethanol (GO:0048149)2.65582469
149thyroid hormone metabolic process (GO:0042403)2.64151022
150L-ascorbic acid metabolic process (GO:0019852)2.64032260
151tachykinin receptor signaling pathway (GO:0007217)2.59593433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.25492380
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14797464
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.90098278
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.37473777
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14968675
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.98820694
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81892752
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93053406
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80353038
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07926389
11VDR_22108803_ChIP-Seq_LS180_Human3.00478664
12ZNF274_21170338_ChIP-Seq_K562_Hela2.72048866
13GBX2_23144817_ChIP-Seq_PC3_Human2.65469669
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28552351
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21376014
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21229156
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12388466
18IGF1R_20145208_ChIP-Seq_DFB_Human2.10648313
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06410524
20* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7738820
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.95672868
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93896589
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88472278
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82192783
25P300_19829295_ChIP-Seq_ESCs_Human1.81900017
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78262984
27ER_23166858_ChIP-Seq_MCF-7_Human1.76679741
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72417672
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.71502196
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69327574
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64702507
32CDX2_22108803_ChIP-Seq_LS180_Human1.62755915
33STAT3_23295773_ChIP-Seq_U87_Human1.60453219
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60141574
35FUS_26573619_Chip-Seq_HEK293_Human1.58768771
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58705996
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57584065
38HTT_18923047_ChIP-ChIP_STHdh_Human1.56835650
39CLOCK_20551151_ChIP-Seq_293T_Human1.54719479
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52022762
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52016886
42TCF4_22108803_ChIP-Seq_LS180_Human1.50559245
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49619133
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49610230
45CBP_20019798_ChIP-Seq_JUKART_Human1.49610230
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47567850
47TCF4_23295773_ChIP-Seq_U87_Human1.47548885
48TAF15_26573619_Chip-Seq_HEK293_Human1.46915559
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44343093
50SMAD4_21799915_ChIP-Seq_A2780_Human1.44254922
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43012009
52AR_25329375_ChIP-Seq_VCAP_Human1.42202751
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42158775
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39435159
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39053653
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.38395905
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.37433996
58SOX2_19829295_ChIP-Seq_ESCs_Human1.36980860
59NANOG_19829295_ChIP-Seq_ESCs_Human1.36980860
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36894342
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36660916
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30721669
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30613573
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.29332545
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29332545
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28126820
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28124356
68GATA1_22025678_ChIP-Seq_K562_Human1.26764191
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23820216
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.23783426
71EWS_26573619_Chip-Seq_HEK293_Human1.21887449
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21280981
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20491754
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18990400
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18663299
76TP53_16413492_ChIP-PET_HCT116_Human1.18402146
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17881222
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17600537
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17105806
80IRF1_19129219_ChIP-ChIP_H3396_Human1.16835903
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16613398
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.16118935
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.15928544
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15851359
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14354693
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14354693
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14154570
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13723673
89* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12575691
90RUNX2_22187159_ChIP-Seq_PCA_Human1.12531610
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12091898
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.11638714
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.10769168
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09648295
95RXR_22108803_ChIP-Seq_LS180_Human1.09476499
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.09430426
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08837000
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06409144
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06306237
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05463905
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05246407
102P53_22387025_ChIP-Seq_ESCs_Mouse1.04703878
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.04609953
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.03563102
105CJUN_26792858_Chip-Seq_BT549_Human1.03420617
106EZH2_22144423_ChIP-Seq_EOC_Human1.02982851
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02458883
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00436440
109RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95954452
110* GATA4_25053715_ChIP-Seq_YYC3_Human0.95222119
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85891589
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83778007
113ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83342033
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81313386
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79623579
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.79104724
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78738774
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78531285
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.77817675
120* RARA_24833708_ChIP-Seq_LIVER_Mouse0.77481454
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76504418
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.75808620
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74869298
124ZNF263_19887448_ChIP-Seq_K562_Human0.73049565
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73024165
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71079339
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70764686
128* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70143750
129* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68989406
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68986503
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68392828
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65025809
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65025809
134* RARB_24833708_ChIP-Seq_LIVER_Mouse0.64256239
135LXR_22292898_ChIP-Seq_THP-1_Human0.61602267
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60876615
137MYC_19915707_ChIP-ChIP_AK7_Human0.59773107
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59567863
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.59178282
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.58992231
141CEBPB_22108803_ChIP-Seq_LS180_Human0.57136500
142GATA6_25053715_ChIP-Seq_YYC3_Human0.56831709
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.56829570
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55636679
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.55561200
146* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54833457
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.53352787
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.51898078
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.51835040
150TAF2_19829295_ChIP-Seq_ESCs_Human0.50432195
151AR_20517297_ChIP-Seq_VCAP_Human0.49548146
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49285306
153* SOX2_20726797_ChIP-Seq_SW620_Human0.49221683
154FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49132932
155GATA1_19941826_ChIP-Seq_K562_Human0.48817794
156ERG_21242973_ChIP-ChIP_JURKAT_Human0.48602096
157P53_21459846_ChIP-Seq_SAOS-2_Human0.48404744
158GATA1_19941827_ChIP-Seq_MEL_Mouse0.47981093
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47281204
160STAT1_17558387_ChIP-Seq_HELA_Human0.47113061
161GATA2_19941826_ChIP-Seq_K562_Human0.46496736
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46253384
163CBP_21632823_ChIP-Seq_H3396_Human0.44843898
164* EGR1_19032775_ChIP-ChIP_M12_Human0.43887894
165NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.43738914
166PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.40494467
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40126668
168STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40010693
169GATA3_24758297_ChIP-Seq_MCF-7_Human0.39005648
170BCAT_22108803_ChIP-Seq_LS180_Human0.38918347
171SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.38807034
172SRY_22984422_ChIP-ChIP_TESTIS_Rat0.38229301
173RACK7_27058665_Chip-Seq_MCF-7_Human0.37346865
174BCOR_27268052_Chip-Seq_Bcells_Human0.37224381
175MYC_27129775_Chip-Seq_CORNEA_Mouse0.37088407
176CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36611456
177NCOR_22424771_ChIP-Seq_293T_Human0.36436399
178CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36029247
179MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.35964510
180ERG_20517297_ChIP-Seq_VCAP_Human0.35924512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14095355
2MP0005360_urolithiasis7.60344149
3MP0005085_abnormal_gallbladder_physiolo6.37921432
4MP0005365_abnormal_bile_salt6.10385436
5MP0008875_abnormal_xenobiotic_pharmacok5.10769827
6MP0003806_abnormal_nucleotide_metabolis4.30591344
7MP0003252_abnormal_bile_duct3.89294964
8MP0010329_abnormal_lipoprotein_level3.60138928
9MP0009840_abnormal_foam_cell3.25389073
10MP0005083_abnormal_biliary_tract3.02648054
11MP0001666_abnormal_nutrient_absorption2.78366864
12MP0005332_abnormal_amino_acid2.68546856
13MP0003195_calcinosis2.67406678
14MP0004043_abnormal_pH_regulation2.65014717
15MP0004147_increased_porphyrin_level2.49386342
16MP0003191_abnormal_cellular_cholesterol2.44815199
17MP0004019_abnormal_vitamin_homeostasis2.23492776
18MP0000609_abnormal_liver_physiology2.14110661
19MP0002118_abnormal_lipid_homeostasis2.07629166
20MP0005551_abnormal_eye_electrophysiolog2.01685642
21MP0002138_abnormal_hepatobiliary_system1.93786845
22MP0003183_abnormal_peptide_metabolism1.93063404
23MP0003868_abnormal_feces_composition1.92655866
24MP0005319_abnormal_enzyme/_coenzyme1.82905067
25MP0000569_abnormal_digit_pigmentation1.63211742
26MP0001764_abnormal_homeostasis1.62614987
27MP0005377_hearing/vestibular/ear_phenot1.59078107
28MP0003878_abnormal_ear_physiology1.59078107
29MP0005584_abnormal_enzyme/coenzyme_acti1.56335787
30MP0009697_abnormal_copulation1.56278445
31* MP0001501_abnormal_sleep_pattern1.48422181
32MP0001664_abnormal_digestion1.47339282
33MP0002102_abnormal_ear_morphology1.42885869
34MP0005451_abnormal_body_composition1.38534795
35MP0003011_delayed_dark_adaptation1.38466586
36MP0001986_abnormal_taste_sensitivity1.38232886
37MP0000427_abnormal_hair_cycle1.32323384
38MP0001485_abnormal_pinna_reflex1.31942329
39MP0009643_abnormal_urine_homeostasis1.31908163
40MP0000372_irregular_coat_pigmentation1.31890871
41MP0010386_abnormal_urinary_bladder1.27036330
42MP0003705_abnormal_hypodermis_morpholog1.27031998
43MP0003656_abnormal_erythrocyte_physiolo1.25163218
44MP0003186_abnormal_redox_activity1.23649172
45MP0003646_muscle_fatigue1.21284545
46MP0005174_abnormal_tail_pigmentation1.19576557
47MP0000538_abnormal_urinary_bladder1.18673442
48MP0000598_abnormal_liver_morphology1.16459725
49MP0000604_amyloidosis1.10502198
50MP0005253_abnormal_eye_physiology1.09803706
51MP0009780_abnormal_chondrocyte_physiolo1.09357345
52MP0005647_abnormal_sex_gland1.09115943
53MP0005645_abnormal_hypothalamus_physiol1.08531003
54MP0003136_yellow_coat_color1.06870444
55MP0001765_abnormal_ion_homeostasis1.06741191
56MP0003879_abnormal_hair_cell1.05028820
57MP0001324_abnormal_eye_pigmentation1.03868950
58MP0005636_abnormal_mineral_homeostasis1.02379842
59MP0002254_reproductive_system_inflammat1.02184745
60MP0009764_decreased_sensitivity_to1.00944558
61MP0002938_white_spotting0.98965946
62MP0010368_abnormal_lymphatic_system0.96725667
63MP0001968_abnormal_touch/_nociception0.96233128
64MP0003950_abnormal_plasma_membrane0.96056014
65MP0009763_increased_sensitivity_to0.96055990
66MP0002638_abnormal_pupillary_reflex0.95397854
67MP0008469_abnormal_protein_level0.89003816
68MP0003866_abnormal_defecation0.88375220
69MP0005084_abnormal_gallbladder_morpholo0.88344490
70MP0009642_abnormal_blood_homeostasis0.87521426
71MP0000383_abnormal_hair_follicle0.87454397
72MP0002822_catalepsy0.87155014
73MP0005646_abnormal_pituitary_gland0.84229806
74MP0008775_abnormal_heart_ventricle0.84139233
75MP0005408_hypopigmentation0.83284193
76MP0009053_abnormal_anal_canal0.83007661
77MP0010234_abnormal_vibrissa_follicle0.82514926
78MP0010155_abnormal_intestine_physiology0.82348663
79MP0005376_homeostasis/metabolism_phenot0.79715611
80MP0005410_abnormal_fertilization0.78462081
81MP0004885_abnormal_endolymph0.77749835
82MP0006036_abnormal_mitochondrial_physio0.77281063
83MP0002876_abnormal_thyroid_physiology0.76900285
84MP0008877_abnormal_DNA_methylation0.76327003
85MP0009745_abnormal_behavioral_response0.75890513
86MP0006072_abnormal_retinal_apoptosis0.74742964
87MP0005195_abnormal_posterior_eye0.74382521
88MP0002078_abnormal_glucose_homeostasis0.73686473
89MP0009765_abnormal_xenobiotic_induced0.73570531
90MP0000566_synostosis0.73346028
91MP0005220_abnormal_exocrine_pancreas0.71153238
92MP0006276_abnormal_autonomic_nervous0.71121112
93MP0004142_abnormal_muscle_tone0.70864854
94MP0002971_abnormal_brown_adipose0.68477010
95MP0000015_abnormal_ear_pigmentation0.68178185
96MP0005670_abnormal_white_adipose0.67184339
97MP0001486_abnormal_startle_reflex0.67106708
98MP0005386_behavior/neurological_phenoty0.66552993
99MP0004924_abnormal_behavior0.66552993
100MP0006054_spinal_hemorrhage0.66482451
101MP0005266_abnormal_metabolism0.66219128
102MP0000371_diluted_coat_color0.66070814
103MP0001661_extended_life_span0.65426242
104MP0001756_abnormal_urination0.64590042
105MP0002272_abnormal_nervous_system0.63767142
106MP0002229_neurodegeneration0.63366270
107MP0005334_abnormal_fat_pad0.63293058
108MP0002168_other_aberrant_phenotype0.62616155
109MP0005535_abnormal_body_temperature0.61708944
110MP0004130_abnormal_muscle_cell0.61645386
111MP0000516_abnormal_urinary_system0.61502128
112MP0005367_renal/urinary_system_phenotyp0.61502128
113MP0003690_abnormal_glial_cell0.61343874
114MP0004484_altered_response_of0.60556015
115MP0010678_abnormal_skin_adnexa0.60267058
116MP0005389_reproductive_system_phenotype0.60042046
117MP0003329_amyloid_beta_deposits0.59411638
118MP0000639_abnormal_adrenal_gland0.57966566
119MP0005448_abnormal_energy_balance0.54152095
120MP0004264_abnormal_extraembryonic_tissu0.54049266
121MP0006035_abnormal_mitochondrial_morpho0.52684096
122MP0005464_abnormal_platelet_physiology0.52490882
123MP0002796_impaired_skin_barrier0.50830878
124MP0002136_abnormal_kidney_physiology0.48910211
125MP0004782_abnormal_surfactant_physiolog0.48538813
126MP0003638_abnormal_response/metabolism_0.46619289
127MP0008873_increased_physiological_sensi0.46525293
128MP0005395_other_phenotype0.44624798
129MP0003075_altered_response_to0.44606677
130MP0005166_decreased_susceptibility_to0.43757513
131MP0003718_maternal_effect0.42888454
132MP0008874_decreased_physiological_sensi0.42274373
133MP0005167_abnormal_blood-brain_barrier0.41058558
134MP0008872_abnormal_physiological_respon0.41005629
135MP0009384_cardiac_valve_regurgitation0.40654449
136MP0003724_increased_susceptibility_to0.40594240
137MP0003953_abnormal_hormone_level0.40279003
138MP0002928_abnormal_bile_duct0.38858991
139MP0003436_decreased_susceptibility_to0.38682505
140MP0000579_abnormal_nail_morphology0.37948156
141MP0005666_abnormal_adipose_tissue0.37113610
142MP0005248_abnormal_Harderian_gland0.37030986
143MP0002837_dystrophic_cardiac_calcinosis0.35289991
144MP0004381_abnormal_hair_follicle0.35057499
145MP0000249_abnormal_blood_vessel0.33533888
146MP0004883_abnormal_blood_vessel0.33285089
147MP0006082_CNS_inflammation0.33152200
148MP0005058_abnormal_lysosome_morphology0.32062839
149MP0000230_abnormal_systemic_arterial0.31503552
150MP0001243_abnormal_dermal_layer0.31315457
151MP0001845_abnormal_inflammatory_respons0.29526506
152MP0009115_abnormal_fat_cell0.28757482
153MP0001881_abnormal_mammary_gland0.28346680
154MP0002132_abnormal_respiratory_system0.28101070
155MP0003453_abnormal_keratinocyte_physiol0.27796660
156MP0005164_abnormal_response_to0.27436132
157MP0002060_abnormal_skin_morphology0.27403370

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.44304292
2Deep venous thrombosis (HP:0002625)7.40426302
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.17333073
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55860845
5Prolonged partial thromboplastin time (HP:0003645)6.54827184
6Hypobetalipoproteinemia (HP:0003563)6.34657730
7Xanthomatosis (HP:0000991)6.26279398
8Complement deficiency (HP:0004431)5.48450129
9Hyperlipoproteinemia (HP:0010980)5.41338876
10Hypolipoproteinemia (HP:0010981)4.82562517
11Joint hemorrhage (HP:0005261)4.79905402
12Hyperammonemia (HP:0001987)4.55294926
13Abnormality of the common coagulation pathway (HP:0010990)4.44431183
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39860226
15Hyperglycinemia (HP:0002154)4.37820487
16Epidermoid cyst (HP:0200040)4.35896215
17Hypoalphalipoproteinemia (HP:0003233)4.23644864
18Fat malabsorption (HP:0002630)4.23036268
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.18253812
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16331234
21Ketosis (HP:0001946)4.09199424
22Abnormality of methionine metabolism (HP:0010901)4.08779076
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.03235792
24Abnormality of complement system (HP:0005339)4.00616840
25Hyperglycinuria (HP:0003108)3.90366593
26Abnormality of serine family amino acid metabolism (HP:0010894)3.85726098
27Abnormality of glycine metabolism (HP:0010895)3.85726098
28Hypoglycemic coma (HP:0001325)3.83081930
29Conjugated hyperbilirubinemia (HP:0002908)3.79826657
30Abnormality of the intrinsic pathway (HP:0010989)3.77579519
31Hyperventilation (HP:0002883)3.71411897
32Decreased circulating renin level (HP:0003351)3.71291574
33Abnormality of pyrimidine metabolism (HP:0004353)3.62995907
34Hypercholesterolemia (HP:0003124)3.51994867
35Congenital sensorineural hearing impairment (HP:0008527)3.36850833
36Hyperbilirubinemia (HP:0002904)3.31865007
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30550676
38Abnormality of fatty-acid metabolism (HP:0004359)3.30120700
39Pancreatic cysts (HP:0001737)3.26384118
40Abnormality of the renal cortex (HP:0011035)3.22616255
41Spontaneous abortion (HP:0005268)3.15580622
42Steatorrhea (HP:0002570)3.14568767
43Congenital stationary night blindness (HP:0007642)3.13581032
44Abnormality of nucleobase metabolism (HP:0010932)2.99319923
45Hypochromic microcytic anemia (HP:0004840)2.97584283
46Hepatocellular carcinoma (HP:0001402)2.95175140
47Abnormality of serum amino acid levels (HP:0003112)2.94105877
48Delayed CNS myelination (HP:0002188)2.93398507
49Pancreatic fibrosis (HP:0100732)2.91039228
50Myocardial infarction (HP:0001658)2.87933611
51Ketoacidosis (HP:0001993)2.87299044
52Abnormality of vitamin B metabolism (HP:0004340)2.83380234
53Pigmentary retinal degeneration (HP:0001146)2.81836064
54Chronic hepatic failure (HP:0100626)2.75340286
55Metabolic acidosis (HP:0001942)2.75117655
56Glycosuria (HP:0003076)2.74100224
57Abnormality of urine glucose concentration (HP:0011016)2.74100224
58True hermaphroditism (HP:0010459)2.73931586
59Systemic lupus erythematosus (HP:0002725)2.73738261
60Acanthocytosis (HP:0001927)2.72808594
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.71523009
62Metabolic alkalosis (HP:0200114)2.69834893
63Attenuation of retinal blood vessels (HP:0007843)2.68338540
64Abnormality of purine metabolism (HP:0004352)2.67481931
65Proximal tubulopathy (HP:0000114)2.66977033
66Dicarboxylic aciduria (HP:0003215)2.65850153
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65850153
68Skin nodule (HP:0200036)2.65377643
69Molar tooth sign on MRI (HP:0002419)2.61835931
70Abnormality of midbrain morphology (HP:0002418)2.61835931
71Ileus (HP:0002595)2.59850606
72Potter facies (HP:0002009)2.59741070
73Facial shape deformation (HP:0011334)2.59741070
74Tubular atrophy (HP:0000092)2.59555292
75Lethargy (HP:0001254)2.59315328
76Abolished electroretinogram (ERG) (HP:0000550)2.56781531
77Abnormality of renin-angiotensin system (HP:0000847)2.56128801
78Stomach cancer (HP:0012126)2.55080425
79Vascular calcification (HP:0004934)2.54444760
80Fair hair (HP:0002286)2.53952029
81Abnormality of alanine metabolism (HP:0010916)2.53920718
82Hyperalaninemia (HP:0003348)2.53920718
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53920718
84Gaze-evoked nystagmus (HP:0000640)2.49518082
85Hypoglycemic seizures (HP:0002173)2.46024124
86Recurrent gram-negative bacterial infections (HP:0005420)2.45698033
87Gout (HP:0001997)2.45580983
88Abnormal gallbladder morphology (HP:0012437)2.44191398
89Hypothermia (HP:0002045)2.42329827
90Glomerulonephritis (HP:0000099)2.42305385
91Type II lissencephaly (HP:0007260)2.39577621
92Cerebral edema (HP:0002181)2.39508725
93Cholelithiasis (HP:0001081)2.38995429
94Spastic diplegia (HP:0001264)2.37243514
95Malnutrition (HP:0004395)2.35139840
96Neonatal onset (HP:0003623)2.34103635
97Amyloidosis (HP:0011034)2.33883602
98Cholecystitis (HP:0001082)2.33832519
99Abnormal gallbladder physiology (HP:0012438)2.33832519
100Large for gestational age (HP:0001520)2.33589705
101Esophageal varix (HP:0002040)2.32568953
102Irritability (HP:0000737)2.30859543
103Gingival bleeding (HP:0000225)2.28213561
104Abnormality of macular pigmentation (HP:0008002)2.27131930
105Abnormality of the renal medulla (HP:0100957)2.26299645
106Mitral stenosis (HP:0001718)2.25536490
107Cardiovascular calcification (HP:0011915)2.25175325
108Nephronophthisis (HP:0000090)2.23091503
109Sensorimotor neuropathy (HP:0007141)2.22943460
110Confusion (HP:0001289)2.20582790
111Generalized hypopigmentation of hair (HP:0011358)2.19579827
112Hyperactive renin-angiotensin system (HP:0000841)2.19370452
113Pancreatitis (HP:0001733)2.17608615
114Chronic diarrhea (HP:0002028)2.15379236
115Menorrhagia (HP:0000132)2.15229067
116Cystic liver disease (HP:0006706)2.14916549
117Late onset (HP:0003584)2.14862896
118Abnormal cartilage morphology (HP:0002763)2.14116570
119Abnormal rod and cone electroretinograms (HP:0008323)2.13989077
120Pendular nystagmus (HP:0012043)2.13962933
121Thrombophlebitis (HP:0004418)2.09097277
122Poikilocytosis (HP:0004447)2.08908024
123Enlarged kidneys (HP:0000105)2.08315981
124Decreased central vision (HP:0007663)2.07433858
125Chorioretinal atrophy (HP:0000533)2.07027793
126Abnormal biliary tract physiology (HP:0012439)2.06223418
127Bile duct proliferation (HP:0001408)2.06223418
128Bony spicule pigmentary retinopathy (HP:0007737)2.06199615
129Vomiting (HP:0002013)2.05777064
130Abnormality of the fovea (HP:0000493)2.05453932
131Brushfield spots (HP:0001088)2.04518312
132Abnormality of the gallbladder (HP:0005264)2.02468420
133Macular degeneration (HP:0000608)2.01202819
134Medial flaring of the eyebrow (HP:0010747)2.00495638
135Hemorrhage of the eye (HP:0011885)1.98604466
136Thyroid-stimulating hormone excess (HP:0002925)1.97439362
137Generalized aminoaciduria (HP:0002909)1.97352842
138Opisthotonus (HP:0002179)1.97046788
139Hyperinsulinemic hypoglycemia (HP:0000825)1.96781908
140Rickets (HP:0002748)1.94955826
141Methylmalonic aciduria (HP:0012120)1.94881654
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91740832
143Hyperaldosteronism (HP:0000859)1.89877041
144Abnormality of transition element cation homeostasis (HP:0011030)1.88792652
145Abnormality of iron homeostasis (HP:0011031)1.88741726
146Abnormality of proline metabolism (HP:0010907)1.88339027
147Hydroxyprolinuria (HP:0003080)1.88339027
148Keratoconus (HP:0000563)1.86190848
149Increased corneal curvature (HP:0100692)1.86190848
150Abnormal albumin level (HP:0012116)1.85460455
151Hypoalbuminemia (HP:0003073)1.85460455
152Progressive inability to walk (HP:0002505)1.84945159
153Genetic anticipation (HP:0003743)1.84564353
154Inability to walk (HP:0002540)1.84305887
155Alkalosis (HP:0001948)1.84145349
156Hypokalemia (HP:0002900)1.83491411
157Abnormal enzyme/coenzyme activity (HP:0012379)1.83375243
158Furrowed tongue (HP:0000221)1.82843517
159Abnormality of vitamin metabolism (HP:0100508)1.80618049
160Hypophosphatemic rickets (HP:0004912)1.78076597
161Renal cortical cysts (HP:0000803)1.77742956
162Elevated hepatic transaminases (HP:0002910)1.76507845
163Nephritis (HP:0000123)1.72810839
164Hyperuricemia (HP:0002149)1.69221870
165Increased purine levels (HP:0004368)1.69221870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.56180675
2TAOK35.18764222
3ACVR1B4.77391385
4ERN14.34184748
5FGFR44.24419050
6SIK14.05111911
7ADRBK23.64553520
8ERBB42.87191560
9MST1R2.85501362
10INSRR2.59124425
11BMPR1B2.40412830
12STK392.33267518
13MAP2K42.06166573
14ZAK2.04838305
15WNK32.02032070
16OXSR11.99510330
17NUAK11.97112175
18PKN21.96649860
19CASK1.95365521
20MAP4K21.94765213
21WNK41.92191759
22MAPK111.90911580
23FRK1.81774547
24PIK3CG1.73530065
25PTK61.67905191
26TRIB31.65783520
27FLT31.59071266
28TYK21.58544639
29LATS11.48236358
30GRK61.46060122
31RIPK11.41540894
32ABL21.38649263
33DAPK21.35513869
34NEK91.32237124
35MST41.28554077
36ADRBK11.28076956
37TBK11.26842213
38KDR1.23825263
39TNIK1.22195694
40AKT31.21962536
41PRKCE1.14033291
42PIK3CA1.13714766
43MAP3K71.12078849
44JAK21.10880707
45MET1.10477820
46ERBB21.09352223
47MAPK131.09196955
48MAP3K141.08493626
49FGFR21.08075589
50MAP3K41.04946093
51PRKAA21.04824963
52MAP2K31.02394788
53FER1.02322354
54LMTK21.01601976
55TXK1.01525293
56MAP3K100.98239446
57STK30.94520517
58MAP3K30.94257163
59EPHB20.92388686
60NLK0.91693628
61EPHB10.91527570
62TEC0.91119050
63MAP3K110.89538690
64EPHA20.88716938
65MAP2K20.87110666
66MAPK40.86385542
67IRAK10.84504173
68JAK10.84315706
69PTK20.83063153
70MKNK20.82553239
71PDK20.82258829
72PRKCZ0.82010247
73PINK10.81647198
74MAP3K120.81639624
75TLK10.81557837
76TGFBR10.80387292
77CAMKK20.79429302
78CAMK2G0.75020774
79CSK0.73886625
80TIE10.73820681
81PRKACG0.72846428
82MAPK150.72487062
83MUSK0.70193389
84STK240.70153062
85STK38L0.69495809
86MAPK120.69487326
87BRSK20.69082176
88PTK2B0.68661935
89CDK60.67273845
90PDPK10.65514006
91MAP2K10.64009385
92MAP2K60.63695720
93IKBKE0.62511194
94MAPKAPK30.61890107
95GSK3A0.61858664
96ICK0.61777701
97EPHA30.60671458
98DYRK1B0.60184796
99PRKAA10.59320698
100BCR0.57694096
101NTRK30.56838831
102CSNK1A1L0.56195455
103TRPM70.55902959
104IKBKB0.52497775
105TAOK20.51043439
106PRKCQ0.50739427
107CSNK1G20.48736628
108CAMK1D0.48612591
109TGFBR20.48554504
110PHKG10.48407782
111PHKG20.48407782
112SGK30.47207485
113CAMK2A0.46708665
114GRK10.46701045
115PRKACA0.46183696
116KIT0.45576607
117MAPK70.44955169
118MAP3K130.43829758
119PRKCI0.43473646
120IRAK30.43253930
121GRK50.43130126
122MAP3K10.42809517
123CSF1R0.42196446
124PKN10.41936348
125CHUK0.41543160
126PDK10.41358874
127IGF1R0.40634980
128CSNK1G30.40202307
129KSR20.39722363
130CSNK1A10.39541615
131GRK70.39377221
132MAP3K20.38912278
133FGFR30.37981438
134RET0.37507095
135MAPKAPK50.37081043
136MAP3K50.36672367
137MATK0.34379580
138EGFR0.32463746
139TRIM280.32270631
140PRKCA0.31847670
141PRKG10.31399412
142TAOK10.31363423
143MTOR0.30983698
144PRKCG0.30276314
145CSNK1G10.29925123
146ERBB30.29813546
147SGK4940.29519132
148SGK2230.29519132
149EPHA40.28568539
150TNK20.28471649
151MAP2K70.28219336
152EIF2AK30.27842972
153PRKCB0.27793500
154MYLK0.27375029
155SGK20.26469926
156PRKG20.25424266
157PBK0.23320545
158PAK30.21511427
159CDK40.21010605
160PDGFRA0.20496987
161ITK0.18299894
162BMX0.17632653
163CAMK40.16941502

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.49181261
2Nitrogen metabolism_Homo sapiens_hsa009103.53656603
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35172434
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23670409
5Arginine biosynthesis_Homo sapiens_hsa002202.99660499
6Complement and coagulation cascades_Homo sapiens_hsa046102.79944954
7Tryptophan metabolism_Homo sapiens_hsa003802.68968213
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64677798
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53284321
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50668925
11Fatty acid degradation_Homo sapiens_hsa000712.46184073
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39795495
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23896804
14Butanoate metabolism_Homo sapiens_hsa006502.20106464
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18130764
16Peroxisome_Homo sapiens_hsa041462.02834057
17Chemical carcinogenesis_Homo sapiens_hsa052041.99598383
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96256141
19Histidine metabolism_Homo sapiens_hsa003401.92687040
20Propanoate metabolism_Homo sapiens_hsa006401.87846981
21PPAR signaling pathway_Homo sapiens_hsa033201.86917136
22Caffeine metabolism_Homo sapiens_hsa002321.83390472
23* Steroid hormone biosynthesis_Homo sapiens_hsa001401.82278603
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79350325
25Sulfur metabolism_Homo sapiens_hsa009201.78150976
26Fatty acid metabolism_Homo sapiens_hsa012121.75129998
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73758099
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.73201662
29Staphylococcus aureus infection_Homo sapiens_hsa051501.72671223
30Retinol metabolism_Homo sapiens_hsa008301.69989912
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68389432
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65863065
33beta-Alanine metabolism_Homo sapiens_hsa004101.65326127
34Bile secretion_Homo sapiens_hsa049761.58462539
35Selenocompound metabolism_Homo sapiens_hsa004501.55581060
36Phenylalanine metabolism_Homo sapiens_hsa003601.53906366
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45977959
38Tyrosine metabolism_Homo sapiens_hsa003501.42417264
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41820826
40Pyruvate metabolism_Homo sapiens_hsa006201.32964408
41Fat digestion and absorption_Homo sapiens_hsa049751.31052833
42Fatty acid elongation_Homo sapiens_hsa000621.29520612
43Starch and sucrose metabolism_Homo sapiens_hsa005001.29390710
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.28729990
45Steroid biosynthesis_Homo sapiens_hsa001001.24650185
46Folate biosynthesis_Homo sapiens_hsa007901.19413033
47ABC transporters_Homo sapiens_hsa020101.16931967
48Biosynthesis of amino acids_Homo sapiens_hsa012301.14770274
49Carbon metabolism_Homo sapiens_hsa012001.12494797
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11959120
51Sulfur relay system_Homo sapiens_hsa041221.09815133
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.05250142
53Phototransduction_Homo sapiens_hsa047441.04180166
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98143946
55Vitamin B6 metabolism_Homo sapiens_hsa007500.97328456
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96869455
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.95627281
58Arginine and proline metabolism_Homo sapiens_hsa003300.94772796
59Vitamin digestion and absorption_Homo sapiens_hsa049770.91197857
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87672262
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87182680
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84863528
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81042247
64Sphingolipid metabolism_Homo sapiens_hsa006000.79475915
65Lysine degradation_Homo sapiens_hsa003100.73845968
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71589944
67Glycerolipid metabolism_Homo sapiens_hsa005610.70325754
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69851523
69Glutathione metabolism_Homo sapiens_hsa004800.69752084
70One carbon pool by folate_Homo sapiens_hsa006700.68754840
71Protein digestion and absorption_Homo sapiens_hsa049740.62907290
72Pentose phosphate pathway_Homo sapiens_hsa000300.61029070
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56050405
74Serotonergic synapse_Homo sapiens_hsa047260.47887955
75Fatty acid biosynthesis_Homo sapiens_hsa000610.47007285
76* Metabolic pathways_Homo sapiens_hsa011000.46727011
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45945090
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.45311426
79Nicotine addiction_Homo sapiens_hsa050330.43126819
80Prion diseases_Homo sapiens_hsa050200.39794216
81Taste transduction_Homo sapiens_hsa047420.35488650
82Galactose metabolism_Homo sapiens_hsa000520.35399418
83Pancreatic secretion_Homo sapiens_hsa049720.34813041
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33301256
85Linoleic acid metabolism_Homo sapiens_hsa005910.32769029
86Fructose and mannose metabolism_Homo sapiens_hsa000510.32544242
87Insulin secretion_Homo sapiens_hsa049110.29844095
88Olfactory transduction_Homo sapiens_hsa047400.24914476
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24745780
90Salivary secretion_Homo sapiens_hsa049700.21813678
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20118719
92Insulin resistance_Homo sapiens_hsa049310.19954008
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.19364175
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.18884674
95Dorso-ventral axis formation_Homo sapiens_hsa043200.15326518
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.14726513
97Asthma_Homo sapiens_hsa053100.13970835
98Renin secretion_Homo sapiens_hsa049240.10377834
99Morphine addiction_Homo sapiens_hsa050320.09827589
100Circadian rhythm_Homo sapiens_hsa047100.09063609
101Glutamatergic synapse_Homo sapiens_hsa047240.07697311
102Glucagon signaling pathway_Homo sapiens_hsa049220.04906948
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02991055
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02525211
105* Ovarian steroidogenesis_Homo sapiens_hsa04913-0.2246140
106Amoebiasis_Homo sapiens_hsa05146-0.2122104
107Ether lipid metabolism_Homo sapiens_hsa00565-0.2026686
108Bladder cancer_Homo sapiens_hsa05219-0.1942808
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1903974
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1777592
111Regulation of autophagy_Homo sapiens_hsa04140-0.1754582
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1618517
113Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1383111
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1356542
115Hepatitis C_Homo sapiens_hsa05160-0.1323911
116Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1277211
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1261738
118Renin-angiotensin system_Homo sapiens_hsa04614-0.1235143
119Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1231979
120African trypanosomiasis_Homo sapiens_hsa05143-0.1208705
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1144893
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1142183
123Mineral absorption_Homo sapiens_hsa04978-0.1101919
124AMPK signaling pathway_Homo sapiens_hsa04152-0.0112012

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