HSD17B4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.06733969
2L-phenylalanine catabolic process (GO:0006559)7.06733969
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77704181
4L-phenylalanine metabolic process (GO:0006558)6.77704181
5aromatic amino acid family catabolic process (GO:0009074)6.28257987
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91915559
7* alpha-linolenic acid metabolic process (GO:0036109)5.74069677
8glyoxylate metabolic process (GO:0046487)5.64579396
9tryptophan catabolic process (GO:0006569)5.60432099
10indole-containing compound catabolic process (GO:0042436)5.60432099
11indolalkylamine catabolic process (GO:0046218)5.60432099
12kynurenine metabolic process (GO:0070189)5.57036136
13* bile acid biosynthetic process (GO:0006699)5.42614485
14tryptophan metabolic process (GO:0006568)5.28273314
15sulfur amino acid catabolic process (GO:0000098)5.27000440
16urea cycle (GO:0000050)5.17149501
17urea metabolic process (GO:0019627)5.17149501
18cysteine metabolic process (GO:0006534)5.14965761
19complement activation, alternative pathway (GO:0006957)5.00713342
20negative regulation of fibrinolysis (GO:0051918)4.97286444
21lysine metabolic process (GO:0006553)4.95627855
22lysine catabolic process (GO:0006554)4.95627855
23* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93598728
24high-density lipoprotein particle remodeling (GO:0034375)4.92393760
25regulation of triglyceride catabolic process (GO:0010896)4.86605317
26peptidyl-glutamic acid carboxylation (GO:0017187)4.84638766
27protein carboxylation (GO:0018214)4.84638766
28regulation of protein activation cascade (GO:2000257)4.83128379
29nitrogen cycle metabolic process (GO:0071941)4.78099598
30serine family amino acid catabolic process (GO:0009071)4.73847617
31regulation of fibrinolysis (GO:0051917)4.70257162
32amino-acid betaine metabolic process (GO:0006577)4.69209535
33* bile acid metabolic process (GO:0008206)4.65835721
34homocysteine metabolic process (GO:0050667)4.61306483
35L-serine metabolic process (GO:0006563)4.55073237
36regulation of complement activation (GO:0030449)4.54949856
37aromatic amino acid family metabolic process (GO:0009072)4.52740282
38regulation of cholesterol esterification (GO:0010872)4.42555252
39cellular ketone body metabolic process (GO:0046950)4.40969120
40alpha-amino acid catabolic process (GO:1901606)4.40668678
41plasma lipoprotein particle clearance (GO:0034381)4.38983278
42acylglycerol homeostasis (GO:0055090)4.38156425
43triglyceride homeostasis (GO:0070328)4.38156425
44reverse cholesterol transport (GO:0043691)4.37262361
45tyrosine metabolic process (GO:0006570)4.36703263
46plasma lipoprotein particle remodeling (GO:0034369)4.33613202
47protein-lipid complex remodeling (GO:0034368)4.33613202
48macromolecular complex remodeling (GO:0034367)4.33613202
49ethanol oxidation (GO:0006069)4.26506923
50negative regulation of sterol transport (GO:0032372)4.18345520
51negative regulation of cholesterol transport (GO:0032375)4.18345520
52phospholipid efflux (GO:0033700)4.16018930
53acetyl-CoA metabolic process (GO:0006084)4.15811816
54cellular amino acid catabolic process (GO:0009063)4.14618302
55short-chain fatty acid metabolic process (GO:0046459)4.10835840
56coenzyme catabolic process (GO:0009109)4.09232891
57* fatty acid beta-oxidation (GO:0006635)4.06839479
58glycine metabolic process (GO:0006544)3.99570095
59serine family amino acid metabolic process (GO:0009069)3.97483153
60positive regulation of fatty acid beta-oxidation (GO:0032000)3.94738211
61cellular modified amino acid catabolic process (GO:0042219)3.94284936
62* fatty acid oxidation (GO:0019395)3.94134138
63positive regulation of lipid catabolic process (GO:0050996)3.93514338
64cellular glucuronidation (GO:0052695)3.92642766
65bile acid and bile salt transport (GO:0015721)3.92330248
66glutamate metabolic process (GO:0006536)3.91888331
67indolalkylamine metabolic process (GO:0006586)3.90882968
68* lipid oxidation (GO:0034440)3.87002888
69benzene-containing compound metabolic process (GO:0042537)3.85925296
70cholesterol efflux (GO:0033344)3.84321901
71* fatty acid catabolic process (GO:0009062)3.83322401
72epoxygenase P450 pathway (GO:0019373)3.83245375
73serine family amino acid biosynthetic process (GO:0009070)3.80920828
74* organic acid catabolic process (GO:0016054)3.80920096
75* carboxylic acid catabolic process (GO:0046395)3.80920096
76amine catabolic process (GO:0009310)3.80802609
77cellular biogenic amine catabolic process (GO:0042402)3.80802609
78ketone body metabolic process (GO:1902224)3.80410864
79* monocarboxylic acid catabolic process (GO:0072329)3.79432328
80phospholipid homeostasis (GO:0055091)3.74619095
81dicarboxylic acid biosynthetic process (GO:0043650)3.73700225
822-oxoglutarate metabolic process (GO:0006103)3.72602252
83aspartate family amino acid catabolic process (GO:0009068)3.71987876
84drug catabolic process (GO:0042737)3.71261320
85plasma lipoprotein particle assembly (GO:0034377)3.70495124
86biotin metabolic process (GO:0006768)3.70358939
87aldehyde catabolic process (GO:0046185)3.69730089
88carnitine metabolic process (GO:0009437)3.65258468
89imidazole-containing compound metabolic process (GO:0052803)3.65207099
90positive regulation of lipoprotein lipase activity (GO:0051006)3.64473557
91positive regulation of triglyceride lipase activity (GO:0061365)3.64473557
92cholesterol homeostasis (GO:0042632)3.62919364
93fibrinolysis (GO:0042730)3.60460745
94arginine metabolic process (GO:0006525)3.60454545
95negative regulation of lipase activity (GO:0060192)3.59750825
96valine metabolic process (GO:0006573)3.57697336
97sterol homeostasis (GO:0055092)3.57429659
98regulation of cholesterol homeostasis (GO:2000188)3.56673669
99low-density lipoprotein particle remodeling (GO:0034374)3.56231912
100blood coagulation, intrinsic pathway (GO:0007597)3.53741220
101glucuronate metabolic process (GO:0019585)3.51872202
102uronic acid metabolic process (GO:0006063)3.51872202
103very-low-density lipoprotein particle assembly (GO:0034379)3.50509380
104cofactor catabolic process (GO:0051187)3.47990394
105NADPH regeneration (GO:0006740)3.44348367
106protein-lipid complex assembly (GO:0065005)3.44251829
107omega-hydroxylase P450 pathway (GO:0097267)3.42009050
108nuclear pore complex assembly (GO:0051292)3.41236207
109exogenous drug catabolic process (GO:0042738)3.39693521
110pre-miRNA processing (GO:0031054)3.39465488
111positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.33223864
112regulation of apoptotic cell clearance (GO:2000425)3.18086207
113establishment of integrated proviral latency (GO:0075713)3.17958618
114ethanol metabolic process (GO:0006067)3.14271537
115gap junction assembly (GO:0016264)3.10666823
116embryonic retina morphogenesis in camera-type eye (GO:0060059)3.09254375
117regulation of bile acid biosynthetic process (GO:0070857)3.07692304
118plasma lipoprotein particle organization (GO:0071827)2.98368463
119nuclear pore organization (GO:0006999)2.97138722
120fat-soluble vitamin biosynthetic process (GO:0042362)2.95088629
121paraxial mesoderm development (GO:0048339)2.93832956
122proline metabolic process (GO:0006560)2.83949396
123fatty acid homeostasis (GO:0055089)2.83067550
124protein-lipid complex subunit organization (GO:0071825)2.82909848
125tricarboxylic acid metabolic process (GO:0072350)2.82285850
126anterior/posterior axis specification, embryo (GO:0008595)2.79401870
127glutamine family amino acid biosynthetic process (GO:0009084)2.78710198
128tricarboxylic acid cycle (GO:0006099)2.78098125
129positive regulation of SMAD protein import into nucleus (GO:0060391)2.76619947
130negative regulation of protein activation cascade (GO:2000258)2.76471143
131regulation of cholesterol biosynthetic process (GO:0045540)2.75192237
132regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74735736
133protein complex localization (GO:0031503)2.71794162
134primary alcohol catabolic process (GO:0034310)2.71649760
135proline biosynthetic process (GO:0006561)2.71070613
136protein activation cascade (GO:0072376)2.68628545
137cholesterol biosynthetic process (GO:0006695)2.68269627
138drug metabolic process (GO:0017144)2.67655232
139long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.65797056
140negative regulation of lipid transport (GO:0032369)2.64511287
141midgut development (GO:0007494)2.63239317
142COPII vesicle coating (GO:0048208)2.61577218
143fatty-acyl-CoA biosynthetic process (GO:0046949)2.60326093
144transcytosis (GO:0045056)2.60163551
145thioester biosynthetic process (GO:0035384)2.59057859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.91845664
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.89112559
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.54948864
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.25544043
5EGR1_23403033_ChIP-Seq_LIVER_Mouse6.20616835
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92342914
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.64115142
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87718044
9E2F7_22180533_ChIP-Seq_HELA_Human3.70835341
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.60937650
11AR_21909140_ChIP-Seq_LNCAP_Human3.33458722
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.18447166
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.83327643
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57452718
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52200751
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52200751
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52200751
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47753698
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.35729710
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.32355066
21CLOCK_20551151_ChIP-Seq_293T_Human2.28314504
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.12027840
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08500737
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07039425
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05678203
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02719700
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2383378
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.95898609
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94785695
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81066657
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79890563
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75648973
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73805489
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72260734
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.63407796
36GATA1_22025678_ChIP-Seq_K562_Human1.61683823
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60661247
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54394020
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52029286
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51760677
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46906369
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.43525434
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42977041
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42411124
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42034555
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38108333
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35868244
48SOX17_20123909_ChIP-Seq_XEN_Mouse1.35771525
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.34072165
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34020317
51HTT_18923047_ChIP-ChIP_STHdh_Human1.29224584
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28883426
53NANOG_21062744_ChIP-ChIP_HESCs_Human1.24940484
54EOMES_21245162_ChIP-Seq_HESCs_Human1.23341391
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20341116
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19810812
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18404761
58NANOG_16518401_ChIP-PET_MESCs_Mouse1.16751253
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16303970
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15762076
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15355653
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14469812
63EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12557209
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.12165926
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10949805
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06112509
67NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05931617
68* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05042441
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04812944
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03532265
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02700164
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02697508
73* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02094327
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01678128
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01518934
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00246194
77SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99911922
78* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99762924
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99505613
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98858017
81MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98825837
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98596583
83* GATA4_25053715_ChIP-Seq_YYC3_Human0.98443613
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96619572
85* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96126416
86PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95700494
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94504292
88ESR2_21235772_ChIP-Seq_MCF-7_Human0.94129531
89YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94085067
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94053318
91CHD1_26751641_Chip-Seq_LNCaP_Human0.94016073
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.93732120
93E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93065124
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.92674706
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92278682
96* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92180766
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.92023199
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90808719
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90794088
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.90766262
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90627872
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89961076
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89040979
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88665884
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88115507
106ZNF263_19887448_ChIP-Seq_K562_Human0.87602433
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87540374
108TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86716173
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.86515611
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86389959
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86261570
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86215383
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86068580
114IGF1R_20145208_ChIP-Seq_DFB_Human0.86022812
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85741668
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84631515
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81678129
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.79498843
119* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77893645
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77372329
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74642321
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.74554253
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73823437
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73443818
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73443818
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70569531
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.68174595
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65259763
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.65106192
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64679204
131LXR_22292898_ChIP-Seq_THP-1_Human0.63779214
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63495447
133* CEBPB_22108803_ChIP-Seq_LS180_Human0.62628552
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.61615535
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.61615535
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.61478983
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.60522550
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59643868
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59242000
140EGR1_19032775_ChIP-ChIP_M12_Human0.57007222
141SOX2_20726797_ChIP-Seq_SW620_Human0.56893711
142GATA1_19941826_ChIP-Seq_K562_Human0.56859703
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.55673477
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.54536015
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.54364128
146GATA6_25053715_ChIP-Seq_YYC3_Human0.52373536
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52175322
148GATA2_19941826_ChIP-Seq_K562_Human0.51341459
149KAP1_22055183_ChIP-Seq_ESCs_Mouse0.50420631
150BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50172645
151AR_20517297_ChIP-Seq_VCAP_Human0.50050543
152RACK7_27058665_Chip-Seq_MCF-7_Human0.48845157
153CBP_21632823_ChIP-Seq_H3396_Human0.48524272
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47710833
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46859166
156* GATA3_24758297_ChIP-Seq_MCF-7_Human0.46553232
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.46110988
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.45187882
159* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.44850105
160POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.44580515
161GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44401521
162MYC_19915707_ChIP-ChIP_AK7_Human0.44277947
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.43597497
164KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.41072491
165P53_21459846_ChIP-Seq_SAOS-2_Human0.40891763
166SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.40403866
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40325980
168EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39668237
169BRD4_27068464_Chip-Seq_AML-cells_Mouse0.39520236
170TAF2_19829295_ChIP-Seq_ESCs_Human0.39118339
171CSB_26484114_Chip-Seq_FIBROBLAST_Human0.39062583
172BCOR_27268052_Chip-Seq_Bcells_Human0.39061586
173TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.39008540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.88345284
2MP0005360_urolithiasis7.24251079
3MP0005085_abnormal_gallbladder_physiolo5.93583444
4* MP0005365_abnormal_bile_salt5.66588274
5MP0008875_abnormal_xenobiotic_pharmacok4.71348350
6MP0003806_abnormal_nucleotide_metabolis4.07436906
7MP0003252_abnormal_bile_duct3.71164925
8MP0010329_abnormal_lipoprotein_level3.61442243
9MP0003941_abnormal_skin_development3.57216007
10MP0009840_abnormal_foam_cell3.22363213
11MP0003890_abnormal_embryonic-extraembry2.99219678
12MP0005332_abnormal_amino_acid2.92272714
13MP0005083_abnormal_biliary_tract2.74996383
14MP0003195_calcinosis2.59886402
15MP0003191_abnormal_cellular_cholesterol2.50774280
16* MP0001666_abnormal_nutrient_absorption2.37894578
17* MP0002118_abnormal_lipid_homeostasis2.22803925
18MP0004272_abnormal_basement_membrane2.18969216
19MP0010352_gastrointestinal_tract_polyps2.16784006
20MP0000609_abnormal_liver_physiology2.16719205
21MP0004019_abnormal_vitamin_homeostasis2.10355493
22MP0010234_abnormal_vibrissa_follicle1.89291035
23MP0004957_abnormal_blastocyst_morpholog1.88276355
24MP0005319_abnormal_enzyme/_coenzyme1.85920125
25MP0001730_embryonic_growth_arrest1.84646522
26MP0002138_abnormal_hepatobiliary_system1.76194242
27MP0005670_abnormal_white_adipose1.71865761
28MP0005584_abnormal_enzyme/coenzyme_acti1.67891605
29MP0004264_abnormal_extraembryonic_tissu1.64382834
30MP0003566_abnormal_cell_adhesion1.62825004
31MP0003868_abnormal_feces_composition1.60966631
32MP0001764_abnormal_homeostasis1.54639380
33MP0003186_abnormal_redox_activity1.48415632
34MP0001915_intracranial_hemorrhage1.48409943
35MP0002697_abnormal_eye_size1.47987470
36MP0003705_abnormal_hypodermis_morpholog1.47408812
37MP0005451_abnormal_body_composition1.46968292
38MP0008932_abnormal_embryonic_tissue1.45646207
39MP0009643_abnormal_urine_homeostasis1.45526034
40MP0000537_abnormal_urethra_morphology1.42178545
41MP0004130_abnormal_muscle_cell1.39419036
42MP0003011_delayed_dark_adaptation1.35939343
43MP0003693_abnormal_embryo_hatching1.30071923
44MP0002084_abnormal_developmental_patter1.29630173
45MP0002090_abnormal_vision1.26680810
46MP0009703_decreased_birth_body1.26166680
47MP0009697_abnormal_copulation1.24777270
48MP0003567_abnormal_fetal_cardiomyocyte1.21384222
49MP0001672_abnormal_embryogenesis/_devel1.19892843
50MP0005380_embryogenesis_phenotype1.19892843
51MP0005666_abnormal_adipose_tissue1.19741243
52MP0001177_atelectasis1.18631513
53MP0000598_abnormal_liver_morphology1.15508472
54MP0003111_abnormal_nucleus_morphology1.14930959
55MP0003119_abnormal_digestive_system1.14371522
56MP0003984_embryonic_growth_retardation1.13516361
57MP0003122_maternal_imprinting1.13081161
58MP0002088_abnormal_embryonic_growth/wei1.12439389
59MP0000604_amyloidosis1.10048411
60MP0001849_ear_inflammation1.08541353
61MP0002877_abnormal_melanocyte_morpholog1.08351567
62MP0002971_abnormal_brown_adipose1.08155869
63MP0001293_anophthalmia1.06443991
64MP0003937_abnormal_limbs/digits/tail_de1.06288085
65MP0008007_abnormal_cellular_replicative1.04897657
66MP0005647_abnormal_sex_gland1.04793898
67MP0003656_abnormal_erythrocyte_physiolo1.04404713
68MP0006036_abnormal_mitochondrial_physio1.03920096
69MP0002085_abnormal_embryonic_tissue1.01507215
70MP0008057_abnormal_DNA_replication1.01010596
71MP0009763_increased_sensitivity_to0.98997310
72MP0003690_abnormal_glial_cell0.98355990
73MP0002233_abnormal_nose_morphology0.97884588
74MP0009764_decreased_sensitivity_to0.95864158
75MP0002086_abnormal_extraembryonic_tissu0.95787778
76MP0002254_reproductive_system_inflammat0.95730802
77MP0006054_spinal_hemorrhage0.94112870
78MP0010678_abnormal_skin_adnexa0.93453633
79MP0001984_abnormal_olfaction0.93113147
80MP0000566_synostosis0.92590387
81MP0001697_abnormal_embryo_size0.92086934
82MP0002837_dystrophic_cardiac_calcinosis0.91933033
83MP0002092_abnormal_eye_morphology0.91467327
84MP0010368_abnormal_lymphatic_system0.90229485
85MP0005636_abnormal_mineral_homeostasis0.90086485
86MP0001661_extended_life_span0.89426707
87MP0001299_abnormal_eye_distance/0.89139859
88MP0005076_abnormal_cell_differentiation0.88484804
89MP0010307_abnormal_tumor_latency0.87973587
90MP0005334_abnormal_fat_pad0.87613395
91MP0008469_abnormal_protein_level0.86011399
92MP0009642_abnormal_blood_homeostasis0.85309469
93MP0003632_abnormal_nervous_system0.85084821
94MP0000579_abnormal_nail_morphology0.83563363
95MP0002078_abnormal_glucose_homeostasis0.82996031
96MP0002080_prenatal_lethality0.81529669
97MP0003718_maternal_effect0.81164896
98MP0004233_abnormal_muscle_weight0.80633237
99MP0001756_abnormal_urination0.80261441
100MP0000428_abnormal_craniofacial_morphol0.79644446
101MP0004185_abnormal_adipocyte_glucose0.79472590
102MP0002111_abnormal_tail_morphology0.78601914
103MP0005535_abnormal_body_temperature0.78456439
104MP0005376_homeostasis/metabolism_phenot0.78394123
105MP0005408_hypopigmentation0.78324958
106MP0005257_abnormal_intraocular_pressure0.78239695
107MP0004197_abnormal_fetal_growth/weight/0.77177252
108MP0003077_abnormal_cell_cycle0.75122156
109MP0010630_abnormal_cardiac_muscle0.74066899
110MP0002876_abnormal_thyroid_physiology0.73728864
111MP0010094_abnormal_chromosome_stability0.71979275
112MP0001286_abnormal_eye_development0.70880158
113MP0005058_abnormal_lysosome_morphology0.70713975
114MP0005266_abnormal_metabolism0.69777731
115MP0000350_abnormal_cell_proliferation0.69668112
116MP0003329_amyloid_beta_deposits0.69354871
117MP0009765_abnormal_xenobiotic_induced0.69053227
118MP0008438_abnormal_cutaneous_collagen0.68897067
119MP0000647_abnormal_sebaceous_gland0.67588220
120MP0000462_abnormal_digestive_system0.67579295
121MP0005220_abnormal_exocrine_pancreas0.66681059
122MP0005084_abnormal_gallbladder_morpholo0.64313458
123MP0005375_adipose_tissue_phenotype0.64175642
124MP0002136_abnormal_kidney_physiology0.62778605
125MP0009053_abnormal_anal_canal0.62332200
126MP0005448_abnormal_energy_balance0.62115876
127MP0009115_abnormal_fat_cell0.61570999
128MP0009384_cardiac_valve_regurgitation0.56153976
129MP0006035_abnormal_mitochondrial_morpho0.56114249
130MP0003724_increased_susceptibility_to0.54416182
131MP0002796_impaired_skin_barrier0.51462490
132MP0002970_abnormal_white_adipose0.50752494
133MP0004782_abnormal_surfactant_physiolog0.47007498
134MP0004043_abnormal_pH_regulation0.45418397
135MP0005395_other_phenotype0.44771563
136MP0003638_abnormal_response/metabolism_0.44657990
137MP0000639_abnormal_adrenal_gland0.44244068
138MP0000230_abnormal_systemic_arterial0.43144067
139MP0003075_altered_response_to0.42684815
140MP0005464_abnormal_platelet_physiology0.42401525
141MP0005330_cardiomyopathy0.41490708
142MP0002168_other_aberrant_phenotype0.40885310
143MP0003953_abnormal_hormone_level0.39814516
144MP0001881_abnormal_mammary_gland0.39105776
145MP0002060_abnormal_skin_morphology0.38982183
146MP0000249_abnormal_blood_vessel0.38860689
147MP0008873_increased_physiological_sensi0.38327650
148MP0005166_decreased_susceptibility_to0.38115976
149MP0003959_abnormal_lean_body0.36752366
150MP0002295_abnormal_pulmonary_circulatio0.35596618
151MP0003300_gastrointestinal_ulcer0.35477917
152MP0009672_abnormal_birth_weight0.34376653
153MP0004381_abnormal_hair_follicle0.33943758
154MP0006082_CNS_inflammation0.33512482
155MP0005248_abnormal_Harderian_gland0.33108179
156MP0005164_abnormal_response_to0.32565109
157MP0008874_decreased_physiological_sensi0.32233852
158MP0003436_decreased_susceptibility_to0.32032727
159MP0002269_muscular_atrophy0.31938824
160MP0005167_abnormal_blood-brain_barrier0.31505387

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.67490155
2Deep venous thrombosis (HP:0002625)6.66943815
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.62782756
4Xanthomatosis (HP:0000991)6.00847454
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.97202112
6Hypobetalipoproteinemia (HP:0003563)5.79241432
7Prolonged partial thromboplastin time (HP:0003645)5.55384440
8Hyperlipoproteinemia (HP:0010980)5.13164863
9Complement deficiency (HP:0004431)5.11483977
10Hyperammonemia (HP:0001987)4.89286420
11Hyperglycinuria (HP:0003108)4.61450329
12Hypolipoproteinemia (HP:0010981)4.52164280
13Hyperglycinemia (HP:0002154)4.51282014
14Abnormality of serine family amino acid metabolism (HP:0010894)4.49325095
15Abnormality of glycine metabolism (HP:0010895)4.49325095
16Ketosis (HP:0001946)4.46670694
17Epidermoid cyst (HP:0200040)4.38171764
18Hypoglycemic coma (HP:0001325)4.25154662
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.24550148
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.20148298
21Joint hemorrhage (HP:0005261)4.07811480
22Hypoalphalipoproteinemia (HP:0003233)4.07526464
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04277748
24Abnormality of fatty-acid metabolism (HP:0004359)4.03418615
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.00947630
26Abnormality of the common coagulation pathway (HP:0010990)3.92390338
27Abnormality of methionine metabolism (HP:0010901)3.90012427
28Fat malabsorption (HP:0002630)3.84430163
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.79033097
30Abnormality of complement system (HP:0005339)3.75108967
31Hypercholesterolemia (HP:0003124)3.49211313
32Ketoacidosis (HP:0001993)3.43816370
33Abnormality of the intrinsic pathway (HP:0010989)3.34531126
34Abnormality of pyrimidine metabolism (HP:0004353)3.32512307
35Conjugated hyperbilirubinemia (HP:0002908)3.29401440
36Abnormality of serum amino acid levels (HP:0003112)3.14961022
37Multiple enchondromatosis (HP:0005701)3.13057806
38Dicarboxylic aciduria (HP:0003215)3.12370378
39Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12370378
40Delayed CNS myelination (HP:0002188)3.11050397
41Hyperbilirubinemia (HP:0002904)3.06823979
42Abnormality of nucleobase metabolism (HP:0010932)3.05752191
43Hepatoblastoma (HP:0002884)2.92867213
44Metabolic acidosis (HP:0001942)2.92711144
45Abnormality of purine metabolism (HP:0004352)2.92372132
46Steatorrhea (HP:0002570)2.90076990
47Myocardial infarction (HP:0001658)2.83920617
48Skin nodule (HP:0200036)2.82144469
49Hepatocellular carcinoma (HP:0001402)2.79090015
50Systemic lupus erythematosus (HP:0002725)2.78739177
51Lethargy (HP:0001254)2.76834201
52Papillary thyroid carcinoma (HP:0002895)2.67106949
53Increased serum pyruvate (HP:0003542)2.61379146
54Generalized aminoaciduria (HP:0002909)2.59601258
55Gout (HP:0001997)2.54889313
56Cerebral edema (HP:0002181)2.53936917
57Agnosia (HP:0010524)2.51367097
58Abnormality of glycolysis (HP:0004366)2.47850653
59Back pain (HP:0003418)2.43319479
60Vascular calcification (HP:0004934)2.43100661
61Spontaneous abortion (HP:0005268)2.41438353
62Abnormality of proline metabolism (HP:0010907)2.35864766
63Hydroxyprolinuria (HP:0003080)2.35864766
64Choanal stenosis (HP:0000452)2.34708291
65Hypoglycemic seizures (HP:0002173)2.34601697
66Malnutrition (HP:0004395)2.34436101
67Abnormal gallbladder morphology (HP:0012437)2.33678368
68Cholelithiasis (HP:0001081)2.30330346
69Vomiting (HP:0002013)2.30025444
70Esophageal varix (HP:0002040)2.29379964
71Osteomalacia (HP:0002749)2.29131277
72Irritability (HP:0000737)2.28180942
73Glomerulonephritis (HP:0000099)2.24540049
74Pancreatitis (HP:0001733)2.24386029
75Proximal tubulopathy (HP:0000114)2.23438692
76Cardiovascular calcification (HP:0011915)2.22057697
77Amyloidosis (HP:0011034)2.20147611
78Abnormal gallbladder physiology (HP:0012438)2.18032937
79Cholecystitis (HP:0001082)2.18032937
80Mitral stenosis (HP:0001718)2.17505843
81Neonatal onset (HP:0003623)2.17278788
82Hypochromic microcytic anemia (HP:0004840)2.16734994
83Hemorrhage of the eye (HP:0011885)2.16105646
84Acanthocytosis (HP:0001927)2.15969211
85Brushfield spots (HP:0001088)2.15835419
86Symptomatic seizures (HP:0011145)2.14821102
87Abnormal cartilage morphology (HP:0002763)2.13906460
88Bifid scrotum (HP:0000048)2.13284975
89Recurrent gram-negative bacterial infections (HP:0005420)2.11706191
90Late onset (HP:0003584)2.08642850
91Rhabdomyosarcoma (HP:0002859)2.06240525
92Enlarged kidneys (HP:0000105)2.02917360
93Pseudobulbar signs (HP:0002200)2.02617327
94Nausea (HP:0002018)2.02187063
95Hyperuricemia (HP:0002149)2.01868938
96Increased purine levels (HP:0004368)2.01868938
97Hypertriglyceridemia (HP:0002155)2.01285981
98Abnormality of urine glucose concentration (HP:0011016)1.99726469
99Glycosuria (HP:0003076)1.99726469
100Renal cortical cysts (HP:0000803)1.98635795
101Myoglobinuria (HP:0002913)1.98492463
102Insidious onset (HP:0003587)1.94980891
103Termporal pattern (HP:0011008)1.94980891
104Neurofibrillary tangles (HP:0002185)1.94196217
105Alkalosis (HP:0001948)1.93926433
106Right ventricular cardiomyopathy (HP:0011663)1.92173661
107Vaginal fistula (HP:0004320)1.91994700
108Hyperinsulinemic hypoglycemia (HP:0000825)1.91868602
109Opisthotonus (HP:0002179)1.91755806
110Abnormality of the gallbladder (HP:0005264)1.91201026
111Thyroid carcinoma (HP:0002890)1.87911477
112Gingival bleeding (HP:0000225)1.84238325
113Rickets (HP:0002748)1.82749473
114Abnormality of vitamin metabolism (HP:0100508)1.82407140
115Thrombophlebitis (HP:0004418)1.81710028
116Gastrointestinal carcinoma (HP:0002672)1.80451845
117Malignant gastrointestinal tract tumors (HP:0006749)1.80451845
118Abnormality of transition element cation homeostasis (HP:0011030)1.79608348
119Abnormality of iron homeostasis (HP:0011031)1.79531244
120Nephritis (HP:0000123)1.79330172
121Scanning speech (HP:0002168)1.78412265
122Atrioventricular block (HP:0001678)1.77797561
123Hemangiomatosis (HP:0007461)1.76879236
124* Spastic diplegia (HP:0001264)1.75137935
125Tetraparesis (HP:0002273)1.75090063
126Cerebral inclusion bodies (HP:0100314)1.71402239
127Myelomeningocele (HP:0002475)1.70926336
128Disinhibition (HP:0000734)1.68461839
129Pancreatic islet-cell hyperplasia (HP:0004510)1.68418023
130Exercise-induced muscle cramps (HP:0003710)1.67881941
131Abnormal delivery (HP:0001787)1.64508205
132Medulloblastoma (HP:0002885)1.63169069
133Anal stenosis (HP:0002025)1.63100973
134Upper motor neuron abnormality (HP:0002127)1.60881868
135Impaired pain sensation (HP:0007328)1.59553152
136Abnormality of pain sensation (HP:0010832)1.59553152
137Elevated alkaline phosphatase (HP:0003155)1.58010222
138Coronal craniosynostosis (HP:0004440)1.56349243
139Turricephaly (HP:0000262)1.55875404
140Biliary tract neoplasm (HP:0100574)1.55666500
141Vacuolated lymphocytes (HP:0001922)1.54799755
142Nephroblastoma (Wilms tumor) (HP:0002667)1.54148955
143Ependymoma (HP:0002888)1.53838172
144Visceral angiomatosis (HP:0100761)1.53184696
145Absent eyebrow (HP:0002223)1.53181124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.21960295
2SIK14.43127059
3ERN13.92671044
4FGFR43.69296043
5TSSK63.48183316
6TRIB33.02207245
7TTK2.95660060
8ACVR1B2.80727267
9PKN22.56703450
10MKNK12.55736087
11ERBB42.35827048
12TNIK2.15482303
13INSRR2.07505889
14MST1R2.04274564
15LATS22.01367031
16TAOK31.95944724
17MKNK21.93352596
18CAMK1D1.93064679
19FLT31.80142186
20SRPK11.77645849
21ALK1.75776570
22NEK91.67139602
23MAPK111.66103605
24PLK31.65653435
25CDC71.57366888
26FGFR21.54742616
27PTK61.53676870
28EEF2K1.52752457
29EPHB11.48508222
30LATS11.47554026
31PDK31.43780463
32PDK41.43780463
33RIPK11.42525409
34MAP2K41.41274774
35NTRK11.39286503
36EIF2AK31.39017239
37BRD41.36149160
38PIK3CG1.35049079
39PNCK1.34385738
40PRKAA21.32956753
41TYK21.32092959
42ABL21.29953621
43FER1.27105458
44MET1.26081573
45FRK1.24737675
46KDR1.24440664
47MAP3K71.15956944
48CDK121.14844489
49MAP3K101.14650198
50LMTK21.12205170
51SCYL21.10730205
52CASK1.09899352
53BCR1.09583932
54PAK41.07838063
55JAK21.05754576
56CAMK1G1.05732766
57TGFBR21.05227853
58STK241.04243065
59TRIM281.04071631
60BMPR1B1.03295014
61CDK191.02525245
62MAP2K31.02228938
63TAF11.01221796
64WNK31.01116294
65TIE10.99651196
66BRSK20.99040234
67EIF2AK10.97694204
68YES10.97257069
69JAK10.96333872
70FGFR30.95663739
71PDK20.95135045
72ERBB20.93237040
73PLK40.91120259
74MAP3K90.90201395
75TBK10.86971474
76STK30.83533017
77DMPK0.82676790
78CDK60.80409416
79PINK10.79411564
80DAPK20.79139736
81GSK3A0.77198836
82MAP3K30.76894313
83CSK0.75975427
84CSNK1E0.75399295
85SMG10.75246667
86PDPK10.74824500
87WNK40.74305394
88STK38L0.73568136
89PRKAA10.73533452
90ERBB30.73514140
91PRKACG0.72316573
92CSF1R0.71356967
93PRKCZ0.70044468
94MAPK40.68505840
95DYRK1B0.67786064
96KSR20.66367546
97GRK60.65515070
98PIK3CA0.65122369
99TTN0.64050574
100PDGFRA0.63657304
101PLK10.63045311
102ATM0.62038155
103MAPK120.60983571
104NEK60.59856267
105MYLK0.57945991
106PRKDC0.57381098
107NLK0.57295927
108EPHA30.55634827
109LRRK20.55085998
110PTK20.54994704
111MAP3K40.54845133
112ICK0.54839648
113AKT30.54514259
114MTOR0.54493740
115CAMK2G0.54472590
116FGFR10.53713106
117IGF1R0.53406198
118RPS6KA40.52863241
119CHEK10.52847217
120OBSCN0.52564083
121PRKACB0.52291026
122EPHB20.51496142
123RPS6KB10.49967593
124CSNK1G20.49841617
125FGR0.49768446
126OXSR10.48467054
127STK390.47393054
128CDK40.47322102
129RET0.47209252
130PLK20.47197602
131MAP2K10.46923586
132RPS6KB20.46476884
133TGFBR10.46403226
134MST40.46075538
135KSR10.45397479
136PDK10.45351701
137MAPK100.45008356
138PKN10.44883061
139PAK20.44827758
140WEE10.44608824
141CDK180.43821503
142BMX0.43414967
143MAPK150.43238204
144PBK0.43197095
145PRKD10.42908834
146MAP3K110.42852507
147CSNK1G10.42643703
148PRKCQ0.42509522
149CDK10.42408938
150ROCK20.42398697
151PAK30.41568601
152CDK150.40495495
153ATR0.40047797
154SGK30.37642178
155BUB10.37534510
156NEK20.37415656
157TYRO30.36822946
158MAPK70.35617775
159SGK4940.34311564
160SGK2230.34311564
161MAP3K140.33570714
162MAP2K60.31286465
163EGFR0.30806824
164NEK10.30546452
165KIT0.28195300
166IRAK30.27804455
167MAP2K20.27522315
168PRKG20.25275959

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.00117335
2Nitrogen metabolism_Homo sapiens_hsa009103.49117271
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12970142
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95962564
5Fatty acid degradation_Homo sapiens_hsa000712.86712025
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.83443154
7Arginine biosynthesis_Homo sapiens_hsa002202.77635561
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76438070
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75407824
10Tryptophan metabolism_Homo sapiens_hsa003802.64706263
11Propanoate metabolism_Homo sapiens_hsa006402.49632502
12Complement and coagulation cascades_Homo sapiens_hsa046102.42698288
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42037440
14Butanoate metabolism_Homo sapiens_hsa006502.31307344
15Fatty acid metabolism_Homo sapiens_hsa012122.26424451
16PPAR signaling pathway_Homo sapiens_hsa033202.19178740
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15354982
18* Peroxisome_Homo sapiens_hsa041462.12601811
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98475749
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90106049
21beta-Alanine metabolism_Homo sapiens_hsa004101.82914676
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82304784
23Histidine metabolism_Homo sapiens_hsa003401.77720995
24Chemical carcinogenesis_Homo sapiens_hsa052041.76683663
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76358089
26Caffeine metabolism_Homo sapiens_hsa002321.72054970
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.67131173
28Pyruvate metabolism_Homo sapiens_hsa006201.66058355
29Fatty acid elongation_Homo sapiens_hsa000621.66036355
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57831407
31Staphylococcus aureus infection_Homo sapiens_hsa051501.57772816
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.54451737
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53673268
34Retinol metabolism_Homo sapiens_hsa008301.52712133
35Selenocompound metabolism_Homo sapiens_hsa004501.46670701
36Phenylalanine metabolism_Homo sapiens_hsa003601.43734566
37Carbon metabolism_Homo sapiens_hsa012001.41652661
38Sulfur metabolism_Homo sapiens_hsa009201.40809830
39Bile secretion_Homo sapiens_hsa049761.39842985
40Tyrosine metabolism_Homo sapiens_hsa003501.31866428
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29004267
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27091407
43Fat digestion and absorption_Homo sapiens_hsa049751.26197968
44Biosynthesis of amino acids_Homo sapiens_hsa012301.25390482
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.19208921
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17993476
47Steroid biosynthesis_Homo sapiens_hsa001001.16896210
48Folate biosynthesis_Homo sapiens_hsa007901.14882956
49ABC transporters_Homo sapiens_hsa020101.12843588
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97875129
51Arginine and proline metabolism_Homo sapiens_hsa003300.96183291
52Vitamin B6 metabolism_Homo sapiens_hsa007500.94195652
53Fatty acid biosynthesis_Homo sapiens_hsa000610.94140413
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93460526
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92324947
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.89009300
57Glycerolipid metabolism_Homo sapiens_hsa005610.87306829
58Lysine degradation_Homo sapiens_hsa003100.86368315
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86361809
60Sulfur relay system_Homo sapiens_hsa041220.86180362
61Vitamin digestion and absorption_Homo sapiens_hsa049770.84620703
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82763495
63Other glycan degradation_Homo sapiens_hsa005110.78467178
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76152121
65Glutathione metabolism_Homo sapiens_hsa004800.75419668
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.74283832
67Adherens junction_Homo sapiens_hsa045200.70073143
68Pentose phosphate pathway_Homo sapiens_hsa000300.67872723
69Non-homologous end-joining_Homo sapiens_hsa034500.56677679
70One carbon pool by folate_Homo sapiens_hsa006700.53620827
71Tight junction_Homo sapiens_hsa045300.48314337
72* Metabolic pathways_Homo sapiens_hsa011000.46420798
73Sphingolipid metabolism_Homo sapiens_hsa006000.46366853
74Thyroid cancer_Homo sapiens_hsa052160.46337574
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40354475
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.40326353
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33548640
78Insulin resistance_Homo sapiens_hsa049310.32406626
79Fructose and mannose metabolism_Homo sapiens_hsa000510.30542143
80Prion diseases_Homo sapiens_hsa050200.30029830
81Galactose metabolism_Homo sapiens_hsa000520.29579422
82RNA transport_Homo sapiens_hsa030130.29509562
83mRNA surveillance pathway_Homo sapiens_hsa030150.28702917
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27082951
85Mismatch repair_Homo sapiens_hsa034300.26431951
86TGF-beta signaling pathway_Homo sapiens_hsa043500.23923693
87AMPK signaling pathway_Homo sapiens_hsa041520.19297726
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.17782741
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15920771
90Linoleic acid metabolism_Homo sapiens_hsa005910.15472574
91Spliceosome_Homo sapiens_hsa030400.14405922
92Cell cycle_Homo sapiens_hsa041100.11571597
93Glucagon signaling pathway_Homo sapiens_hsa049220.11419699
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11279895
95Endometrial cancer_Homo sapiens_hsa052130.10269328
96N-Glycan biosynthesis_Homo sapiens_hsa005100.09200690
97DNA replication_Homo sapiens_hsa030300.08917472
98Hippo signaling pathway_Homo sapiens_hsa043900.08896355
99Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2072673
100Bladder cancer_Homo sapiens_hsa05219-0.2027136
101Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1977055
102Mineral absorption_Homo sapiens_hsa04978-0.1875294
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1846359
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1810751
105Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1807047
106Hepatitis C_Homo sapiens_hsa05160-0.1753265
107Protein digestion and absorption_Homo sapiens_hsa04974-0.1648808
108Amoebiasis_Homo sapiens_hsa05146-0.1622566
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1586121
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1311808
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1163798
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1099562
113Lysosome_Homo sapiens_hsa04142-0.0985252
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0880477
115Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0544262
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0499442
117Renin-angiotensin system_Homo sapiens_hsa04614-0.0242578
118Insulin signaling pathway_Homo sapiens_hsa04910-0.0242001

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