Rank | Gene Set | Z-score |
---|---|---|
1 | L-phenylalanine catabolic process (GO:0006559) | 7.06733969 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.06733969 |
3 | L-phenylalanine metabolic process (GO:0006558) | 6.77704181 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 6.77704181 |
5 | aromatic amino acid family catabolic process (GO:0009074) | 6.28257987 |
6 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 5.91915559 |
7 | * alpha-linolenic acid metabolic process (GO:0036109) | 5.74069677 |
8 | glyoxylate metabolic process (GO:0046487) | 5.64579396 |
9 | indole-containing compound catabolic process (GO:0042436) | 5.60432099 |
10 | indolalkylamine catabolic process (GO:0046218) | 5.60432099 |
11 | tryptophan catabolic process (GO:0006569) | 5.60432099 |
12 | kynurenine metabolic process (GO:0070189) | 5.57036136 |
13 | * bile acid biosynthetic process (GO:0006699) | 5.42614485 |
14 | tryptophan metabolic process (GO:0006568) | 5.28273314 |
15 | sulfur amino acid catabolic process (GO:0000098) | 5.27000440 |
16 | urea metabolic process (GO:0019627) | 5.17149501 |
17 | urea cycle (GO:0000050) | 5.17149501 |
18 | cysteine metabolic process (GO:0006534) | 5.14965761 |
19 | complement activation, alternative pathway (GO:0006957) | 5.00713342 |
20 | negative regulation of fibrinolysis (GO:0051918) | 4.97286444 |
21 | lysine catabolic process (GO:0006554) | 4.95627855 |
22 | lysine metabolic process (GO:0006553) | 4.95627855 |
23 | * fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.93598728 |
24 | high-density lipoprotein particle remodeling (GO:0034375) | 4.92393760 |
25 | regulation of triglyceride catabolic process (GO:0010896) | 4.86605317 |
26 | protein carboxylation (GO:0018214) | 4.84638766 |
27 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.84638766 |
28 | regulation of protein activation cascade (GO:2000257) | 4.83128379 |
29 | nitrogen cycle metabolic process (GO:0071941) | 4.78099598 |
30 | serine family amino acid catabolic process (GO:0009071) | 4.73847617 |
31 | regulation of fibrinolysis (GO:0051917) | 4.70257162 |
32 | amino-acid betaine metabolic process (GO:0006577) | 4.69209535 |
33 | * bile acid metabolic process (GO:0008206) | 4.65835721 |
34 | homocysteine metabolic process (GO:0050667) | 4.61306483 |
35 | L-serine metabolic process (GO:0006563) | 4.55073237 |
36 | regulation of complement activation (GO:0030449) | 4.54949856 |
37 | aromatic amino acid family metabolic process (GO:0009072) | 4.52740282 |
38 | regulation of cholesterol esterification (GO:0010872) | 4.42555252 |
39 | cellular ketone body metabolic process (GO:0046950) | 4.40969120 |
40 | alpha-amino acid catabolic process (GO:1901606) | 4.40668678 |
41 | plasma lipoprotein particle clearance (GO:0034381) | 4.38983278 |
42 | triglyceride homeostasis (GO:0070328) | 4.38156425 |
43 | acylglycerol homeostasis (GO:0055090) | 4.38156425 |
44 | reverse cholesterol transport (GO:0043691) | 4.37262361 |
45 | tyrosine metabolic process (GO:0006570) | 4.36703263 |
46 | protein-lipid complex remodeling (GO:0034368) | 4.33613202 |
47 | macromolecular complex remodeling (GO:0034367) | 4.33613202 |
48 | plasma lipoprotein particle remodeling (GO:0034369) | 4.33613202 |
49 | ethanol oxidation (GO:0006069) | 4.26506923 |
50 | negative regulation of cholesterol transport (GO:0032375) | 4.18345520 |
51 | negative regulation of sterol transport (GO:0032372) | 4.18345520 |
52 | phospholipid efflux (GO:0033700) | 4.16018930 |
53 | acetyl-CoA metabolic process (GO:0006084) | 4.15811816 |
54 | cellular amino acid catabolic process (GO:0009063) | 4.14618302 |
55 | short-chain fatty acid metabolic process (GO:0046459) | 4.10835840 |
56 | coenzyme catabolic process (GO:0009109) | 4.09232891 |
57 | * fatty acid beta-oxidation (GO:0006635) | 4.06839479 |
58 | glycine metabolic process (GO:0006544) | 3.99570095 |
59 | serine family amino acid metabolic process (GO:0009069) | 3.97483153 |
60 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.94738211 |
61 | cellular modified amino acid catabolic process (GO:0042219) | 3.94284936 |
62 | * fatty acid oxidation (GO:0019395) | 3.94134138 |
63 | positive regulation of lipid catabolic process (GO:0050996) | 3.93514338 |
64 | cellular glucuronidation (GO:0052695) | 3.92642766 |
65 | bile acid and bile salt transport (GO:0015721) | 3.92330248 |
66 | glutamate metabolic process (GO:0006536) | 3.91888331 |
67 | indolalkylamine metabolic process (GO:0006586) | 3.90882968 |
68 | * lipid oxidation (GO:0034440) | 3.87002888 |
69 | benzene-containing compound metabolic process (GO:0042537) | 3.85925296 |
70 | cholesterol efflux (GO:0033344) | 3.84321901 |
71 | * fatty acid catabolic process (GO:0009062) | 3.83322401 |
72 | epoxygenase P450 pathway (GO:0019373) | 3.83245375 |
73 | serine family amino acid biosynthetic process (GO:0009070) | 3.80920828 |
74 | * carboxylic acid catabolic process (GO:0046395) | 3.80920096 |
75 | * organic acid catabolic process (GO:0016054) | 3.80920096 |
76 | cellular biogenic amine catabolic process (GO:0042402) | 3.80802609 |
77 | amine catabolic process (GO:0009310) | 3.80802609 |
78 | ketone body metabolic process (GO:1902224) | 3.80410864 |
79 | * monocarboxylic acid catabolic process (GO:0072329) | 3.79432328 |
80 | phospholipid homeostasis (GO:0055091) | 3.74619095 |
81 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.73700225 |
82 | 2-oxoglutarate metabolic process (GO:0006103) | 3.72602252 |
83 | aspartate family amino acid catabolic process (GO:0009068) | 3.71987876 |
84 | drug catabolic process (GO:0042737) | 3.71261320 |
85 | plasma lipoprotein particle assembly (GO:0034377) | 3.70495124 |
86 | biotin metabolic process (GO:0006768) | 3.70358939 |
87 | aldehyde catabolic process (GO:0046185) | 3.69730089 |
88 | carnitine metabolic process (GO:0009437) | 3.65258468 |
89 | imidazole-containing compound metabolic process (GO:0052803) | 3.65207099 |
90 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.64473557 |
91 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.64473557 |
92 | cholesterol homeostasis (GO:0042632) | 3.62919364 |
93 | fibrinolysis (GO:0042730) | 3.60460745 |
94 | arginine metabolic process (GO:0006525) | 3.60454545 |
95 | negative regulation of lipase activity (GO:0060192) | 3.59750825 |
96 | valine metabolic process (GO:0006573) | 3.57697336 |
97 | sterol homeostasis (GO:0055092) | 3.57429659 |
98 | regulation of cholesterol homeostasis (GO:2000188) | 3.56673669 |
99 | low-density lipoprotein particle remodeling (GO:0034374) | 3.56231912 |
100 | blood coagulation, intrinsic pathway (GO:0007597) | 3.53741220 |
101 | uronic acid metabolic process (GO:0006063) | 3.51872202 |
102 | glucuronate metabolic process (GO:0019585) | 3.51872202 |
103 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.50509380 |
104 | cofactor catabolic process (GO:0051187) | 3.47990394 |
105 | NADPH regeneration (GO:0006740) | 3.44348367 |
106 | protein-lipid complex assembly (GO:0065005) | 3.44251829 |
107 | omega-hydroxylase P450 pathway (GO:0097267) | 3.42009050 |
108 | nuclear pore complex assembly (GO:0051292) | 3.41236207 |
109 | exogenous drug catabolic process (GO:0042738) | 3.39693521 |
110 | pre-miRNA processing (GO:0031054) | 3.39465488 |
111 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.33223864 |
112 | regulation of apoptotic cell clearance (GO:2000425) | 3.18086207 |
113 | establishment of integrated proviral latency (GO:0075713) | 3.17958618 |
114 | ethanol metabolic process (GO:0006067) | 3.14271537 |
115 | gap junction assembly (GO:0016264) | 3.10666823 |
116 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 3.09254375 |
117 | regulation of bile acid biosynthetic process (GO:0070857) | 3.07692304 |
118 | plasma lipoprotein particle organization (GO:0071827) | 2.98368463 |
119 | nuclear pore organization (GO:0006999) | 2.97138722 |
120 | fat-soluble vitamin biosynthetic process (GO:0042362) | 2.95088629 |
121 | paraxial mesoderm development (GO:0048339) | 2.93832956 |
122 | proline metabolic process (GO:0006560) | 2.83949396 |
123 | fatty acid homeostasis (GO:0055089) | 2.83067550 |
124 | protein-lipid complex subunit organization (GO:0071825) | 2.82909848 |
125 | tricarboxylic acid metabolic process (GO:0072350) | 2.82285850 |
126 | anterior/posterior axis specification, embryo (GO:0008595) | 2.79401870 |
127 | glutamine family amino acid biosynthetic process (GO:0009084) | 2.78710198 |
128 | tricarboxylic acid cycle (GO:0006099) | 2.78098125 |
129 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.76619947 |
130 | negative regulation of protein activation cascade (GO:2000258) | 2.76471143 |
131 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.75192237 |
132 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 2.74735736 |
133 | protein complex localization (GO:0031503) | 2.71794162 |
134 | primary alcohol catabolic process (GO:0034310) | 2.71649760 |
135 | proline biosynthetic process (GO:0006561) | 2.71070613 |
136 | protein activation cascade (GO:0072376) | 2.68628545 |
137 | cholesterol biosynthetic process (GO:0006695) | 2.68269627 |
138 | drug metabolic process (GO:0017144) | 2.67655232 |
139 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 2.65797056 |
140 | negative regulation of lipid transport (GO:0032369) | 2.64511287 |
141 | midgut development (GO:0007494) | 2.63239317 |
142 | COPII vesicle coating (GO:0048208) | 2.61577218 |
143 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 2.60326093 |
144 | transcytosis (GO:0045056) | 2.60163551 |
145 | thioester biosynthetic process (GO:0035384) | 2.59057859 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 7.91845664 |
2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 6.89112559 |
3 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.54948864 |
4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.25544043 |
5 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.20616835 |
6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.92342914 |
7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.64115142 |
8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.87718044 |
9 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.70835341 |
10 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.60937650 |
11 | AR_21909140_ChIP-Seq_LNCAP_Human | 3.33458722 |
12 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 3.18447166 |
13 | * TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.83327643 |
14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.57452718 |
15 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 2.52200751 |
16 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 2.52200751 |
17 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 2.52200751 |
18 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.47753698 |
19 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 2.35729710 |
20 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.32355066 |
21 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.28314504 |
22 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 2.12027840 |
23 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 2.08500737 |
24 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.07039425 |
25 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.05678203 |
26 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 2.02719700 |
27 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.2383378 |
28 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.95898609 |
29 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.94785695 |
30 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.81066657 |
31 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.79890563 |
32 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.75648973 |
33 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.73805489 |
34 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.72260734 |
35 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.63407796 |
36 | GATA1_22025678_ChIP-Seq_K562_Human | 1.61683823 |
37 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.60661247 |
38 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.54394020 |
39 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.52029286 |
40 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.51760677 |
41 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.46906369 |
42 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.43525434 |
43 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.42977041 |
44 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.42411124 |
45 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.42034555 |
46 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.38108333 |
47 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.35868244 |
48 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.35771525 |
49 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.34072165 |
50 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.34020317 |
51 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.29224584 |
52 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.28883426 |
53 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.24940484 |
54 | EOMES_21245162_ChIP-Seq_HESCs_Human | 1.23341391 |
55 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.20341116 |
56 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.19810812 |
57 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.18404761 |
58 | NANOG_16518401_ChIP-PET_MESCs_Mouse | 1.16751253 |
59 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.16303970 |
60 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.15762076 |
61 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.15355653 |
62 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.14469812 |
63 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.12557209 |
64 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.12165926 |
65 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.10949805 |
66 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.06112509 |
67 | NANOG_18692474_ChIP-Seq_MEFs_Mouse | 1.05931617 |
68 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.05042441 |
69 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.04812944 |
70 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.03532265 |
71 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.02700164 |
72 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.02697508 |
73 | * TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.02094327 |
74 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.01678128 |
75 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.01518934 |
76 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.00246194 |
77 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.99911922 |
78 | * THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.99762924 |
79 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.99505613 |
80 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.98858017 |
81 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.98825837 |
82 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.98596583 |
83 | * GATA4_25053715_ChIP-Seq_YYC3_Human | 0.98443613 |
84 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.96619572 |
85 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.96126416 |
86 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.95700494 |
87 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.94504292 |
88 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.94129531 |
89 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.94085067 |
90 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.94053318 |
91 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.94016073 |
92 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.93732120 |
93 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.93065124 |
94 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.92674706 |
95 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.92278682 |
96 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.92180766 |
97 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.92023199 |
98 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.90808719 |
99 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.90794088 |
100 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.90766262 |
101 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.90627872 |
102 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.89961076 |
103 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.89040979 |
104 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.88665884 |
105 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.88115507 |
106 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.87602433 |
107 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.87540374 |
108 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 0.86716173 |
109 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.86515611 |
110 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.86389959 |
111 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.86261570 |
112 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.86215383 |
113 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.86068580 |
114 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.86022812 |
115 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.85741668 |
116 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.84631515 |
117 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.81678129 |
118 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.79498843 |
119 | * AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.77893645 |
120 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.77372329 |
121 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.74642321 |
122 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.74554253 |
123 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.73823437 |
124 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.73443818 |
125 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.73443818 |
126 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.70569531 |
127 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.68174595 |
128 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.65259763 |
129 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.65106192 |
130 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.64679204 |
131 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.63779214 |
132 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.63495447 |
133 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.62628552 |
134 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.61615535 |
135 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.61615535 |
136 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.61478983 |
137 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.60522550 |
138 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.59643868 |
139 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.59242000 |
140 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.57007222 |
141 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.56893711 |
142 | GATA1_19941826_ChIP-Seq_K562_Human | 0.56859703 |
143 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.55673477 |
144 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.54536015 |
145 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.54364128 |
146 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.52373536 |
147 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.52175322 |
148 | GATA2_19941826_ChIP-Seq_K562_Human | 0.51341459 |
149 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.50420631 |
150 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.50172645 |
151 | AR_20517297_ChIP-Seq_VCAP_Human | 0.50050543 |
152 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.48845157 |
153 | CBP_21632823_ChIP-Seq_H3396_Human | 0.48524272 |
154 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.47710833 |
155 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.46859166 |
156 | * GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.46553232 |
157 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.46110988 |
158 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.45187882 |
159 | * PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.44850105 |
160 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.44580515 |
161 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.44401521 |
162 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.44277947 |
163 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.43597497 |
164 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.41072491 |
165 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.40891763 |
166 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.40403866 |
167 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.40325980 |
168 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.39668237 |
169 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.39520236 |
170 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.39118339 |
171 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.39062583 |
172 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.39061586 |
173 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.39008540 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 7.88345284 |
2 | MP0005360_urolithiasis | 7.24251079 |
3 | MP0005085_abnormal_gallbladder_physiolo | 5.93583444 |
4 | * MP0005365_abnormal_bile_salt | 5.66588274 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.71348350 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.07436906 |
7 | MP0003252_abnormal_bile_duct | 3.71164925 |
8 | MP0010329_abnormal_lipoprotein_level | 3.61442243 |
9 | MP0003941_abnormal_skin_development | 3.57216007 |
10 | MP0009840_abnormal_foam_cell | 3.22363213 |
11 | MP0003890_abnormal_embryonic-extraembry | 2.99219678 |
12 | MP0005332_abnormal_amino_acid | 2.92272714 |
13 | MP0005083_abnormal_biliary_tract | 2.74996383 |
14 | MP0003195_calcinosis | 2.59886402 |
15 | MP0003191_abnormal_cellular_cholesterol | 2.50774280 |
16 | * MP0001666_abnormal_nutrient_absorption | 2.37894578 |
17 | * MP0002118_abnormal_lipid_homeostasis | 2.22803925 |
18 | MP0004272_abnormal_basement_membrane | 2.18969216 |
19 | MP0010352_gastrointestinal_tract_polyps | 2.16784006 |
20 | MP0000609_abnormal_liver_physiology | 2.16719205 |
21 | MP0004019_abnormal_vitamin_homeostasis | 2.10355493 |
22 | MP0010234_abnormal_vibrissa_follicle | 1.89291035 |
23 | MP0004957_abnormal_blastocyst_morpholog | 1.88276355 |
24 | MP0005319_abnormal_enzyme/_coenzyme | 1.85920125 |
25 | MP0001730_embryonic_growth_arrest | 1.84646522 |
26 | MP0002138_abnormal_hepatobiliary_system | 1.76194242 |
27 | MP0005670_abnormal_white_adipose | 1.71865761 |
28 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.67891605 |
29 | MP0004264_abnormal_extraembryonic_tissu | 1.64382834 |
30 | MP0003566_abnormal_cell_adhesion | 1.62825004 |
31 | MP0003868_abnormal_feces_composition | 1.60966631 |
32 | MP0001764_abnormal_homeostasis | 1.54639380 |
33 | MP0003186_abnormal_redox_activity | 1.48415632 |
34 | MP0001915_intracranial_hemorrhage | 1.48409943 |
35 | MP0002697_abnormal_eye_size | 1.47987470 |
36 | MP0003705_abnormal_hypodermis_morpholog | 1.47408812 |
37 | MP0005451_abnormal_body_composition | 1.46968292 |
38 | MP0008932_abnormal_embryonic_tissue | 1.45646207 |
39 | MP0009643_abnormal_urine_homeostasis | 1.45526034 |
40 | MP0000537_abnormal_urethra_morphology | 1.42178545 |
41 | MP0004130_abnormal_muscle_cell | 1.39419036 |
42 | MP0003011_delayed_dark_adaptation | 1.35939343 |
43 | MP0003693_abnormal_embryo_hatching | 1.30071923 |
44 | MP0002084_abnormal_developmental_patter | 1.29630173 |
45 | MP0002090_abnormal_vision | 1.26680810 |
46 | MP0009703_decreased_birth_body | 1.26166680 |
47 | MP0009697_abnormal_copulation | 1.24777270 |
48 | MP0003567_abnormal_fetal_cardiomyocyte | 1.21384222 |
49 | MP0001672_abnormal_embryogenesis/_devel | 1.19892843 |
50 | MP0005380_embryogenesis_phenotype | 1.19892843 |
51 | MP0005666_abnormal_adipose_tissue | 1.19741243 |
52 | MP0001177_atelectasis | 1.18631513 |
53 | MP0000598_abnormal_liver_morphology | 1.15508472 |
54 | MP0003111_abnormal_nucleus_morphology | 1.14930959 |
55 | MP0003119_abnormal_digestive_system | 1.14371522 |
56 | MP0003984_embryonic_growth_retardation | 1.13516361 |
57 | MP0003122_maternal_imprinting | 1.13081161 |
58 | MP0002088_abnormal_embryonic_growth/wei | 1.12439389 |
59 | MP0000604_amyloidosis | 1.10048411 |
60 | MP0001849_ear_inflammation | 1.08541353 |
61 | MP0002877_abnormal_melanocyte_morpholog | 1.08351567 |
62 | MP0002971_abnormal_brown_adipose | 1.08155869 |
63 | MP0001293_anophthalmia | 1.06443991 |
64 | MP0003937_abnormal_limbs/digits/tail_de | 1.06288085 |
65 | MP0008007_abnormal_cellular_replicative | 1.04897657 |
66 | MP0005647_abnormal_sex_gland | 1.04793898 |
67 | MP0003656_abnormal_erythrocyte_physiolo | 1.04404713 |
68 | MP0006036_abnormal_mitochondrial_physio | 1.03920096 |
69 | MP0002085_abnormal_embryonic_tissue | 1.01507215 |
70 | MP0008057_abnormal_DNA_replication | 1.01010596 |
71 | MP0009763_increased_sensitivity_to | 0.98997310 |
72 | MP0003690_abnormal_glial_cell | 0.98355990 |
73 | MP0002233_abnormal_nose_morphology | 0.97884588 |
74 | MP0009764_decreased_sensitivity_to | 0.95864158 |
75 | MP0002086_abnormal_extraembryonic_tissu | 0.95787778 |
76 | MP0002254_reproductive_system_inflammat | 0.95730802 |
77 | MP0006054_spinal_hemorrhage | 0.94112870 |
78 | MP0010678_abnormal_skin_adnexa | 0.93453633 |
79 | MP0001984_abnormal_olfaction | 0.93113147 |
80 | MP0000566_synostosis | 0.92590387 |
81 | MP0001697_abnormal_embryo_size | 0.92086934 |
82 | MP0002837_dystrophic_cardiac_calcinosis | 0.91933033 |
83 | MP0002092_abnormal_eye_morphology | 0.91467327 |
84 | MP0010368_abnormal_lymphatic_system | 0.90229485 |
85 | MP0005636_abnormal_mineral_homeostasis | 0.90086485 |
86 | MP0001661_extended_life_span | 0.89426707 |
87 | MP0001299_abnormal_eye_distance/ | 0.89139859 |
88 | MP0005076_abnormal_cell_differentiation | 0.88484804 |
89 | MP0010307_abnormal_tumor_latency | 0.87973587 |
90 | MP0005334_abnormal_fat_pad | 0.87613395 |
91 | MP0008469_abnormal_protein_level | 0.86011399 |
92 | MP0009642_abnormal_blood_homeostasis | 0.85309469 |
93 | MP0003632_abnormal_nervous_system | 0.85084821 |
94 | MP0000579_abnormal_nail_morphology | 0.83563363 |
95 | MP0002078_abnormal_glucose_homeostasis | 0.82996031 |
96 | MP0002080_prenatal_lethality | 0.81529669 |
97 | MP0003718_maternal_effect | 0.81164896 |
98 | MP0004233_abnormal_muscle_weight | 0.80633237 |
99 | MP0001756_abnormal_urination | 0.80261441 |
100 | MP0000428_abnormal_craniofacial_morphol | 0.79644446 |
101 | MP0004185_abnormal_adipocyte_glucose | 0.79472590 |
102 | MP0002111_abnormal_tail_morphology | 0.78601914 |
103 | MP0005535_abnormal_body_temperature | 0.78456439 |
104 | MP0005376_homeostasis/metabolism_phenot | 0.78394123 |
105 | MP0005408_hypopigmentation | 0.78324958 |
106 | MP0005257_abnormal_intraocular_pressure | 0.78239695 |
107 | MP0004197_abnormal_fetal_growth/weight/ | 0.77177252 |
108 | MP0003077_abnormal_cell_cycle | 0.75122156 |
109 | MP0010630_abnormal_cardiac_muscle | 0.74066899 |
110 | MP0002876_abnormal_thyroid_physiology | 0.73728864 |
111 | MP0010094_abnormal_chromosome_stability | 0.71979275 |
112 | MP0001286_abnormal_eye_development | 0.70880158 |
113 | MP0005058_abnormal_lysosome_morphology | 0.70713975 |
114 | MP0005266_abnormal_metabolism | 0.69777731 |
115 | MP0000350_abnormal_cell_proliferation | 0.69668112 |
116 | MP0003329_amyloid_beta_deposits | 0.69354871 |
117 | MP0009765_abnormal_xenobiotic_induced | 0.69053227 |
118 | MP0008438_abnormal_cutaneous_collagen | 0.68897067 |
119 | MP0000647_abnormal_sebaceous_gland | 0.67588220 |
120 | MP0000462_abnormal_digestive_system | 0.67579295 |
121 | MP0005220_abnormal_exocrine_pancreas | 0.66681059 |
122 | MP0005084_abnormal_gallbladder_morpholo | 0.64313458 |
123 | MP0005375_adipose_tissue_phenotype | 0.64175642 |
124 | MP0002136_abnormal_kidney_physiology | 0.62778605 |
125 | MP0009053_abnormal_anal_canal | 0.62332200 |
126 | MP0005448_abnormal_energy_balance | 0.62115876 |
127 | MP0009115_abnormal_fat_cell | 0.61570999 |
128 | MP0009384_cardiac_valve_regurgitation | 0.56153976 |
129 | MP0006035_abnormal_mitochondrial_morpho | 0.56114249 |
130 | MP0003724_increased_susceptibility_to | 0.54416182 |
131 | MP0002796_impaired_skin_barrier | 0.51462490 |
132 | MP0002970_abnormal_white_adipose | 0.50752494 |
133 | MP0004782_abnormal_surfactant_physiolog | 0.47007498 |
134 | MP0004043_abnormal_pH_regulation | 0.45418397 |
135 | MP0005395_other_phenotype | 0.44771563 |
136 | MP0003638_abnormal_response/metabolism_ | 0.44657990 |
137 | MP0000639_abnormal_adrenal_gland | 0.44244068 |
138 | MP0000230_abnormal_systemic_arterial | 0.43144067 |
139 | MP0003075_altered_response_to | 0.42684815 |
140 | MP0005464_abnormal_platelet_physiology | 0.42401525 |
141 | MP0005330_cardiomyopathy | 0.41490708 |
142 | MP0002168_other_aberrant_phenotype | 0.40885310 |
143 | MP0003953_abnormal_hormone_level | 0.39814516 |
144 | MP0001881_abnormal_mammary_gland | 0.39105776 |
145 | MP0002060_abnormal_skin_morphology | 0.38982183 |
146 | MP0000249_abnormal_blood_vessel | 0.38860689 |
147 | MP0008873_increased_physiological_sensi | 0.38327650 |
148 | MP0005166_decreased_susceptibility_to | 0.38115976 |
149 | MP0003959_abnormal_lean_body | 0.36752366 |
150 | MP0002295_abnormal_pulmonary_circulatio | 0.35596618 |
151 | MP0003300_gastrointestinal_ulcer | 0.35477917 |
152 | MP0009672_abnormal_birth_weight | 0.34376653 |
153 | MP0004381_abnormal_hair_follicle | 0.33943758 |
154 | MP0006082_CNS_inflammation | 0.33512482 |
155 | MP0005248_abnormal_Harderian_gland | 0.33108179 |
156 | MP0005164_abnormal_response_to | 0.32565109 |
157 | MP0008874_decreased_physiological_sensi | 0.32233852 |
158 | MP0003436_decreased_susceptibility_to | 0.32032727 |
159 | MP0002269_muscular_atrophy | 0.31938824 |
160 | MP0005167_abnormal_blood-brain_barrier | 0.31505387 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Intrahepatic cholestasis (HP:0001406) | 6.67490155 |
2 | Deep venous thrombosis (HP:0002625) | 6.66943815 |
3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 6.62782756 |
4 | Xanthomatosis (HP:0000991) | 6.00847454 |
5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.97202112 |
6 | Hypobetalipoproteinemia (HP:0003563) | 5.79241432 |
7 | Prolonged partial thromboplastin time (HP:0003645) | 5.55384440 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.13164863 |
9 | Complement deficiency (HP:0004431) | 5.11483977 |
10 | Hyperammonemia (HP:0001987) | 4.89286420 |
11 | Hyperglycinuria (HP:0003108) | 4.61450329 |
12 | Hypolipoproteinemia (HP:0010981) | 4.52164280 |
13 | Hyperglycinemia (HP:0002154) | 4.51282014 |
14 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.49325095 |
15 | Abnormality of glycine metabolism (HP:0010895) | 4.49325095 |
16 | Ketosis (HP:0001946) | 4.46670694 |
17 | Epidermoid cyst (HP:0200040) | 4.38171764 |
18 | Hypoglycemic coma (HP:0001325) | 4.25154662 |
19 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.24550148 |
20 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.20148298 |
21 | Joint hemorrhage (HP:0005261) | 4.07811480 |
22 | Hypoalphalipoproteinemia (HP:0003233) | 4.07526464 |
23 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.04277748 |
24 | Abnormality of fatty-acid metabolism (HP:0004359) | 4.03418615 |
25 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.00947630 |
26 | Abnormality of the common coagulation pathway (HP:0010990) | 3.92390338 |
27 | Abnormality of methionine metabolism (HP:0010901) | 3.90012427 |
28 | Fat malabsorption (HP:0002630) | 3.84430163 |
29 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.79033097 |
30 | Abnormality of complement system (HP:0005339) | 3.75108967 |
31 | Hypercholesterolemia (HP:0003124) | 3.49211313 |
32 | Ketoacidosis (HP:0001993) | 3.43816370 |
33 | Abnormality of the intrinsic pathway (HP:0010989) | 3.34531126 |
34 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.32512307 |
35 | Conjugated hyperbilirubinemia (HP:0002908) | 3.29401440 |
36 | Abnormality of serum amino acid levels (HP:0003112) | 3.14961022 |
37 | Multiple enchondromatosis (HP:0005701) | 3.13057806 |
38 | Dicarboxylic aciduria (HP:0003215) | 3.12370378 |
39 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.12370378 |
40 | Delayed CNS myelination (HP:0002188) | 3.11050397 |
41 | Hyperbilirubinemia (HP:0002904) | 3.06823979 |
42 | Abnormality of nucleobase metabolism (HP:0010932) | 3.05752191 |
43 | Hepatoblastoma (HP:0002884) | 2.92867213 |
44 | Metabolic acidosis (HP:0001942) | 2.92711144 |
45 | Abnormality of purine metabolism (HP:0004352) | 2.92372132 |
46 | Steatorrhea (HP:0002570) | 2.90076990 |
47 | Myocardial infarction (HP:0001658) | 2.83920617 |
48 | Skin nodule (HP:0200036) | 2.82144469 |
49 | Hepatocellular carcinoma (HP:0001402) | 2.79090015 |
50 | Systemic lupus erythematosus (HP:0002725) | 2.78739177 |
51 | Lethargy (HP:0001254) | 2.76834201 |
52 | Papillary thyroid carcinoma (HP:0002895) | 2.67106949 |
53 | Increased serum pyruvate (HP:0003542) | 2.61379146 |
54 | Generalized aminoaciduria (HP:0002909) | 2.59601258 |
55 | Gout (HP:0001997) | 2.54889313 |
56 | Cerebral edema (HP:0002181) | 2.53936917 |
57 | Agnosia (HP:0010524) | 2.51367097 |
58 | Abnormality of glycolysis (HP:0004366) | 2.47850653 |
59 | Back pain (HP:0003418) | 2.43319479 |
60 | Vascular calcification (HP:0004934) | 2.43100661 |
61 | Spontaneous abortion (HP:0005268) | 2.41438353 |
62 | Abnormality of proline metabolism (HP:0010907) | 2.35864766 |
63 | Hydroxyprolinuria (HP:0003080) | 2.35864766 |
64 | Choanal stenosis (HP:0000452) | 2.34708291 |
65 | Hypoglycemic seizures (HP:0002173) | 2.34601697 |
66 | Malnutrition (HP:0004395) | 2.34436101 |
67 | Abnormal gallbladder morphology (HP:0012437) | 2.33678368 |
68 | Cholelithiasis (HP:0001081) | 2.30330346 |
69 | Vomiting (HP:0002013) | 2.30025444 |
70 | Esophageal varix (HP:0002040) | 2.29379964 |
71 | Osteomalacia (HP:0002749) | 2.29131277 |
72 | Irritability (HP:0000737) | 2.28180942 |
73 | Glomerulonephritis (HP:0000099) | 2.24540049 |
74 | Pancreatitis (HP:0001733) | 2.24386029 |
75 | Proximal tubulopathy (HP:0000114) | 2.23438692 |
76 | Cardiovascular calcification (HP:0011915) | 2.22057697 |
77 | Amyloidosis (HP:0011034) | 2.20147611 |
78 | Abnormal gallbladder physiology (HP:0012438) | 2.18032937 |
79 | Cholecystitis (HP:0001082) | 2.18032937 |
80 | Mitral stenosis (HP:0001718) | 2.17505843 |
81 | Neonatal onset (HP:0003623) | 2.17278788 |
82 | Hypochromic microcytic anemia (HP:0004840) | 2.16734994 |
83 | Hemorrhage of the eye (HP:0011885) | 2.16105646 |
84 | Acanthocytosis (HP:0001927) | 2.15969211 |
85 | Brushfield spots (HP:0001088) | 2.15835419 |
86 | Symptomatic seizures (HP:0011145) | 2.14821102 |
87 | Abnormal cartilage morphology (HP:0002763) | 2.13906460 |
88 | Bifid scrotum (HP:0000048) | 2.13284975 |
89 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.11706191 |
90 | Late onset (HP:0003584) | 2.08642850 |
91 | Rhabdomyosarcoma (HP:0002859) | 2.06240525 |
92 | Enlarged kidneys (HP:0000105) | 2.02917360 |
93 | Pseudobulbar signs (HP:0002200) | 2.02617327 |
94 | Nausea (HP:0002018) | 2.02187063 |
95 | Hyperuricemia (HP:0002149) | 2.01868938 |
96 | Increased purine levels (HP:0004368) | 2.01868938 |
97 | Hypertriglyceridemia (HP:0002155) | 2.01285981 |
98 | Abnormality of urine glucose concentration (HP:0011016) | 1.99726469 |
99 | Glycosuria (HP:0003076) | 1.99726469 |
100 | Renal cortical cysts (HP:0000803) | 1.98635795 |
101 | Myoglobinuria (HP:0002913) | 1.98492463 |
102 | Insidious onset (HP:0003587) | 1.94980891 |
103 | Termporal pattern (HP:0011008) | 1.94980891 |
104 | Neurofibrillary tangles (HP:0002185) | 1.94196217 |
105 | Alkalosis (HP:0001948) | 1.93926433 |
106 | Right ventricular cardiomyopathy (HP:0011663) | 1.92173661 |
107 | Vaginal fistula (HP:0004320) | 1.91994700 |
108 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.91868602 |
109 | Opisthotonus (HP:0002179) | 1.91755806 |
110 | Abnormality of the gallbladder (HP:0005264) | 1.91201026 |
111 | Thyroid carcinoma (HP:0002890) | 1.87911477 |
112 | Gingival bleeding (HP:0000225) | 1.84238325 |
113 | Rickets (HP:0002748) | 1.82749473 |
114 | Abnormality of vitamin metabolism (HP:0100508) | 1.82407140 |
115 | Thrombophlebitis (HP:0004418) | 1.81710028 |
116 | Gastrointestinal carcinoma (HP:0002672) | 1.80451845 |
117 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.80451845 |
118 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.79608348 |
119 | Abnormality of iron homeostasis (HP:0011031) | 1.79531244 |
120 | Nephritis (HP:0000123) | 1.79330172 |
121 | Scanning speech (HP:0002168) | 1.78412265 |
122 | Atrioventricular block (HP:0001678) | 1.77797561 |
123 | Hemangiomatosis (HP:0007461) | 1.76879236 |
124 | * Spastic diplegia (HP:0001264) | 1.75137935 |
125 | Tetraparesis (HP:0002273) | 1.75090063 |
126 | Cerebral inclusion bodies (HP:0100314) | 1.71402239 |
127 | Myelomeningocele (HP:0002475) | 1.70926336 |
128 | Disinhibition (HP:0000734) | 1.68461839 |
129 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.68418023 |
130 | Exercise-induced muscle cramps (HP:0003710) | 1.67881941 |
131 | Abnormal delivery (HP:0001787) | 1.64508205 |
132 | Medulloblastoma (HP:0002885) | 1.63169069 |
133 | Anal stenosis (HP:0002025) | 1.63100973 |
134 | Upper motor neuron abnormality (HP:0002127) | 1.60881868 |
135 | Impaired pain sensation (HP:0007328) | 1.59553152 |
136 | Abnormality of pain sensation (HP:0010832) | 1.59553152 |
137 | Elevated alkaline phosphatase (HP:0003155) | 1.58010222 |
138 | Coronal craniosynostosis (HP:0004440) | 1.56349243 |
139 | Turricephaly (HP:0000262) | 1.55875404 |
140 | Biliary tract neoplasm (HP:0100574) | 1.55666500 |
141 | Vacuolated lymphocytes (HP:0001922) | 1.54799755 |
142 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.54148955 |
143 | Ependymoma (HP:0002888) | 1.53838172 |
144 | Visceral angiomatosis (HP:0100761) | 1.53184696 |
145 | Absent eyebrow (HP:0002223) | 1.53181124 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 7.21960295 |
2 | SIK1 | 4.43127059 |
3 | ERN1 | 3.92671044 |
4 | FGFR4 | 3.69296043 |
5 | TSSK6 | 3.48183316 |
6 | TRIB3 | 3.02207245 |
7 | TTK | 2.95660060 |
8 | ACVR1B | 2.80727267 |
9 | PKN2 | 2.56703450 |
10 | MKNK1 | 2.55736087 |
11 | ERBB4 | 2.35827048 |
12 | TNIK | 2.15482303 |
13 | INSRR | 2.07505889 |
14 | MST1R | 2.04274564 |
15 | LATS2 | 2.01367031 |
16 | TAOK3 | 1.95944724 |
17 | MKNK2 | 1.93352596 |
18 | CAMK1D | 1.93064679 |
19 | FLT3 | 1.80142186 |
20 | SRPK1 | 1.77645849 |
21 | ALK | 1.75776570 |
22 | NEK9 | 1.67139602 |
23 | MAPK11 | 1.66103605 |
24 | PLK3 | 1.65653435 |
25 | CDC7 | 1.57366888 |
26 | FGFR2 | 1.54742616 |
27 | PTK6 | 1.53676870 |
28 | EEF2K | 1.52752457 |
29 | EPHB1 | 1.48508222 |
30 | LATS1 | 1.47554026 |
31 | PDK3 | 1.43780463 |
32 | PDK4 | 1.43780463 |
33 | RIPK1 | 1.42525409 |
34 | MAP2K4 | 1.41274774 |
35 | NTRK1 | 1.39286503 |
36 | EIF2AK3 | 1.39017239 |
37 | BRD4 | 1.36149160 |
38 | PIK3CG | 1.35049079 |
39 | PNCK | 1.34385738 |
40 | PRKAA2 | 1.32956753 |
41 | TYK2 | 1.32092959 |
42 | ABL2 | 1.29953621 |
43 | FER | 1.27105458 |
44 | MET | 1.26081573 |
45 | FRK | 1.24737675 |
46 | KDR | 1.24440664 |
47 | MAP3K7 | 1.15956944 |
48 | CDK12 | 1.14844489 |
49 | MAP3K10 | 1.14650198 |
50 | LMTK2 | 1.12205170 |
51 | SCYL2 | 1.10730205 |
52 | CASK | 1.09899352 |
53 | BCR | 1.09583932 |
54 | PAK4 | 1.07838063 |
55 | JAK2 | 1.05754576 |
56 | CAMK1G | 1.05732766 |
57 | TGFBR2 | 1.05227853 |
58 | STK24 | 1.04243065 |
59 | TRIM28 | 1.04071631 |
60 | BMPR1B | 1.03295014 |
61 | CDK19 | 1.02525245 |
62 | MAP2K3 | 1.02228938 |
63 | TAF1 | 1.01221796 |
64 | WNK3 | 1.01116294 |
65 | TIE1 | 0.99651196 |
66 | BRSK2 | 0.99040234 |
67 | EIF2AK1 | 0.97694204 |
68 | YES1 | 0.97257069 |
69 | JAK1 | 0.96333872 |
70 | FGFR3 | 0.95663739 |
71 | PDK2 | 0.95135045 |
72 | ERBB2 | 0.93237040 |
73 | PLK4 | 0.91120259 |
74 | MAP3K9 | 0.90201395 |
75 | TBK1 | 0.86971474 |
76 | STK3 | 0.83533017 |
77 | DMPK | 0.82676790 |
78 | CDK6 | 0.80409416 |
79 | PINK1 | 0.79411564 |
80 | DAPK2 | 0.79139736 |
81 | GSK3A | 0.77198836 |
82 | MAP3K3 | 0.76894313 |
83 | CSK | 0.75975427 |
84 | CSNK1E | 0.75399295 |
85 | SMG1 | 0.75246667 |
86 | PDPK1 | 0.74824500 |
87 | WNK4 | 0.74305394 |
88 | STK38L | 0.73568136 |
89 | PRKAA1 | 0.73533452 |
90 | ERBB3 | 0.73514140 |
91 | PRKACG | 0.72316573 |
92 | CSF1R | 0.71356967 |
93 | PRKCZ | 0.70044468 |
94 | MAPK4 | 0.68505840 |
95 | DYRK1B | 0.67786064 |
96 | KSR2 | 0.66367546 |
97 | GRK6 | 0.65515070 |
98 | PIK3CA | 0.65122369 |
99 | TTN | 0.64050574 |
100 | PDGFRA | 0.63657304 |
101 | PLK1 | 0.63045311 |
102 | ATM | 0.62038155 |
103 | MAPK12 | 0.60983571 |
104 | NEK6 | 0.59856267 |
105 | MYLK | 0.57945991 |
106 | PRKDC | 0.57381098 |
107 | NLK | 0.57295927 |
108 | EPHA3 | 0.55634827 |
109 | LRRK2 | 0.55085998 |
110 | PTK2 | 0.54994704 |
111 | MAP3K4 | 0.54845133 |
112 | ICK | 0.54839648 |
113 | AKT3 | 0.54514259 |
114 | MTOR | 0.54493740 |
115 | CAMK2G | 0.54472590 |
116 | FGFR1 | 0.53713106 |
117 | IGF1R | 0.53406198 |
118 | RPS6KA4 | 0.52863241 |
119 | CHEK1 | 0.52847217 |
120 | OBSCN | 0.52564083 |
121 | PRKACB | 0.52291026 |
122 | EPHB2 | 0.51496142 |
123 | RPS6KB1 | 0.49967593 |
124 | CSNK1G2 | 0.49841617 |
125 | FGR | 0.49768446 |
126 | OXSR1 | 0.48467054 |
127 | STK39 | 0.47393054 |
128 | CDK4 | 0.47322102 |
129 | RET | 0.47209252 |
130 | PLK2 | 0.47197602 |
131 | MAP2K1 | 0.46923586 |
132 | RPS6KB2 | 0.46476884 |
133 | TGFBR1 | 0.46403226 |
134 | MST4 | 0.46075538 |
135 | KSR1 | 0.45397479 |
136 | PDK1 | 0.45351701 |
137 | MAPK10 | 0.45008356 |
138 | PKN1 | 0.44883061 |
139 | PAK2 | 0.44827758 |
140 | WEE1 | 0.44608824 |
141 | CDK18 | 0.43821503 |
142 | BMX | 0.43414967 |
143 | MAPK15 | 0.43238204 |
144 | PBK | 0.43197095 |
145 | PRKD1 | 0.42908834 |
146 | MAP3K11 | 0.42852507 |
147 | CSNK1G1 | 0.42643703 |
148 | PRKCQ | 0.42509522 |
149 | CDK1 | 0.42408938 |
150 | ROCK2 | 0.42398697 |
151 | PAK3 | 0.41568601 |
152 | CDK15 | 0.40495495 |
153 | ATR | 0.40047797 |
154 | SGK3 | 0.37642178 |
155 | BUB1 | 0.37534510 |
156 | NEK2 | 0.37415656 |
157 | TYRO3 | 0.36822946 |
158 | MAPK7 | 0.35617775 |
159 | SGK223 | 0.34311564 |
160 | SGK494 | 0.34311564 |
161 | MAP3K14 | 0.33570714 |
162 | MAP2K6 | 0.31286465 |
163 | EGFR | 0.30806824 |
164 | NEK1 | 0.30546452 |
165 | KIT | 0.28195300 |
166 | IRAK3 | 0.27804455 |
167 | MAP2K2 | 0.27522315 |
168 | PRKG2 | 0.25275959 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.00117335 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.49117271 |
3 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.12970142 |
4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.95962564 |
5 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.86712025 |
6 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.83443154 |
7 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.77635561 |
8 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.76438070 |
9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.75407824 |
10 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.64706263 |
11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.49632502 |
12 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.42698288 |
13 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.42037440 |
14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.31307344 |
15 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.26424451 |
16 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.19178740 |
17 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.15354982 |
18 | * Peroxisome_Homo sapiens_hsa04146 | 2.12601811 |
19 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.98475749 |
20 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.90106049 |
21 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.82914676 |
22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.82304784 |
23 | Histidine metabolism_Homo sapiens_hsa00340 | 1.77720995 |
24 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.76683663 |
25 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.76358089 |
26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.72054970 |
27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.67131173 |
28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.66058355 |
29 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.66036355 |
30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.57831407 |
31 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.57772816 |
32 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.54451737 |
33 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.53673268 |
34 | Retinol metabolism_Homo sapiens_hsa00830 | 1.52712133 |
35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.46670701 |
36 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.43734566 |
37 | Carbon metabolism_Homo sapiens_hsa01200 | 1.41652661 |
38 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.40809830 |
39 | Bile secretion_Homo sapiens_hsa04976 | 1.39842985 |
40 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.31866428 |
41 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.29004267 |
42 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.27091407 |
43 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.26197968 |
44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.25390482 |
45 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19208921 |
46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.17993476 |
47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.16896210 |
48 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.14882956 |
49 | ABC transporters_Homo sapiens_hsa02010 | 1.12843588 |
50 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.97875129 |
51 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.96183291 |
52 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.94195652 |
53 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.94140413 |
54 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.93460526 |
55 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.92324947 |
56 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.89009300 |
57 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.87306829 |
58 | Lysine degradation_Homo sapiens_hsa00310 | 0.86368315 |
59 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.86361809 |
60 | Sulfur relay system_Homo sapiens_hsa04122 | 0.86180362 |
61 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.84620703 |
62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.82763495 |
63 | Other glycan degradation_Homo sapiens_hsa00511 | 0.78467178 |
64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.76152121 |
65 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.75419668 |
66 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.74283832 |
67 | Adherens junction_Homo sapiens_hsa04520 | 0.70073143 |
68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.67872723 |
69 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.56677679 |
70 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.53620827 |
71 | Tight junction_Homo sapiens_hsa04530 | 0.48314337 |
72 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.46420798 |
73 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.46366853 |
74 | Thyroid cancer_Homo sapiens_hsa05216 | 0.46337574 |
75 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.40354475 |
76 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.40326353 |
77 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.33548640 |
78 | Insulin resistance_Homo sapiens_hsa04931 | 0.32406626 |
79 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.30542143 |
80 | Prion diseases_Homo sapiens_hsa05020 | 0.30029830 |
81 | Galactose metabolism_Homo sapiens_hsa00052 | 0.29579422 |
82 | RNA transport_Homo sapiens_hsa03013 | 0.29509562 |
83 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.28702917 |
84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.27082951 |
85 | Mismatch repair_Homo sapiens_hsa03430 | 0.26431951 |
86 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.23923693 |
87 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.19297726 |
88 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.17782741 |
89 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.15920771 |
90 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.15472574 |
91 | Spliceosome_Homo sapiens_hsa03040 | 0.14405922 |
92 | Cell cycle_Homo sapiens_hsa04110 | 0.11571597 |
93 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.11419699 |
94 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.11279895 |
95 | Endometrial cancer_Homo sapiens_hsa05213 | 0.10269328 |
96 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.09200690 |
97 | DNA replication_Homo sapiens_hsa03030 | 0.08917472 |
98 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.08896355 |
99 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | -0.2072673 |
100 | Bladder cancer_Homo sapiens_hsa05219 | -0.2027136 |
101 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.1977055 |
102 | Mineral absorption_Homo sapiens_hsa04978 | -0.1875294 |
103 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1846359 |
104 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1810751 |
105 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.1807047 |
106 | Hepatitis C_Homo sapiens_hsa05160 | -0.1753265 |
107 | Protein digestion and absorption_Homo sapiens_hsa04974 | -0.1648808 |
108 | Amoebiasis_Homo sapiens_hsa05146 | -0.1622566 |
109 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1586121 |
110 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1311808 |
111 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.1163798 |
112 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.1099562 |
113 | Lysosome_Homo sapiens_hsa04142 | -0.0985252 |
114 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | -0.0880477 |
115 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.0544262 |
116 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.0499442 |
117 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.0242578 |
118 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.0242001 |