ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.85718226
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.52682819
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.26352821
4	ATP synthesis coupled proton transport (GO:0015986)	4.11182793
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.11182793
6	water-soluble vitamin biosynthetic process (GO:0042364)	3.92032652
7	nonmotile primary cilium assembly (GO:0035058)	3.89864983
8	protein complex biogenesis (GO:0070271)	3.86773675
9	pyrimidine nucleobase catabolic process (GO:0006208)	3.82817556
10	DNA deamination (GO:0045006)	3.77744322
11	cornea development in camera-type eye (GO:0061303)	3.75704928
12	epithelial cilium movement (GO:0003351)	3.64635205
13	cilium movement (GO:0003341)	3.62001277
14	axonemal dynein complex assembly (GO:0070286)	3.60818646
15	protein neddylation (GO:0045116)	3.60533169
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.58475007
17	NADH dehydrogenase complex assembly (GO:0010257)	3.58475007
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.58475007
19	negative regulation of telomere maintenance (GO:0032205)	3.49828067
20	indolalkylamine catabolic process (GO:0046218)	3.47975913
21	tryptophan catabolic process (GO:0006569)	3.47975913
22	indole-containing compound catabolic process (GO:0042436)	3.47975913
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.45747450
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.40129431
25	GTP biosynthetic process (GO:0006183)	3.40045104
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.34177136
27	nucleobase catabolic process (GO:0046113)	3.34085261
28	ubiquinone metabolic process (GO:0006743)	3.23497016
29	regulation of cilium movement (GO:0003352)	3.15270834
30	estrogen biosynthetic process (GO:0006703)	3.12415370
31	electron transport chain (GO:0022900)	3.08705699
32	kynurenine metabolic process (GO:0070189)	3.06574712
33	ubiquinone biosynthetic process (GO:0006744)	3.06441132
34	respiratory electron transport chain (GO:0022904)	3.06070782
35	synaptic transmission, cholinergic (GO:0007271)	2.97286892
36	chaperone-mediated protein transport (GO:0072321)	2.96828707
37	substrate-independent telencephalic tangential migration (GO:0021826)	2.93910750
38	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.93910750
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.93052309
40	neuron fate determination (GO:0048664)	2.91803882
41	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.90052458
42	platelet dense granule organization (GO:0060155)	2.88961769
43	retinal ganglion cell axon guidance (GO:0031290)	2.87203579
44	intraciliary transport (GO:0042073)	2.84338240
45	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.82955823
46	axoneme assembly (GO:0035082)	2.82844620
47	somite development (GO:0061053)	2.82710424
48	transmission of nerve impulse (GO:0019226)	2.79546332
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.79187492
50	heme transport (GO:0015886)	2.78278661
51	ribosomal small subunit assembly (GO:0000028)	2.77672892
52	photoreceptor cell development (GO:0042461)	2.77570482
53	indolalkylamine metabolic process (GO:0006586)	2.76411589
54	hydrogen ion transmembrane transport (GO:1902600)	2.76248439
55	behavioral response to ethanol (GO:0048149)	2.76033692
56	cholesterol biosynthetic process (GO:0006695)	2.72521773
57	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.71687543
58	cell proliferation in forebrain (GO:0021846)	2.71539056
59	UTP biosynthetic process (GO:0006228)	2.71238588
60	postsynaptic membrane organization (GO:0001941)	2.70889592
61	gamma-aminobutyric acid transport (GO:0015812)	2.70876238
62	protein polyglutamylation (GO:0018095)	2.70378099
63	tryptophan metabolic process (GO:0006568)	2.69712644
64	respiratory chain complex IV assembly (GO:0008535)	2.68949424
65	resolution of meiotic recombination intermediates (GO:0000712)	2.68586683
66	cilium morphogenesis (GO:0060271)	2.68563674
67	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.67998876
68	viral transcription (GO:0019083)	2.67179412
69	hindbrain development (GO:0030902)	2.65703522
70	presynaptic membrane assembly (GO:0097105)	2.63811879
71	dendritic spine morphogenesis (GO:0060997)	2.61467603
72	replication fork processing (GO:0031297)	2.61378096
73	protein-cofactor linkage (GO:0018065)	2.60725481
74	fucose catabolic process (GO:0019317)	2.60287324
75	L-fucose metabolic process (GO:0042354)	2.60287324
76	L-fucose catabolic process (GO:0042355)	2.60287324
77	negative regulation of response to food (GO:0032096)	2.59918270
78	negative regulation of appetite (GO:0032099)	2.59918270
79	proton transport (GO:0015992)	2.59872749
80	presynaptic membrane organization (GO:0097090)	2.59661347
81	cytochrome complex assembly (GO:0017004)	2.59399617
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.59363267
83	translational termination (GO:0006415)	2.56661543
84	hydrogen transport (GO:0006818)	2.56009630
85	spinal cord development (GO:0021510)	2.54501171
86	neural tube formation (GO:0001841)	2.53769955
87	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.53463557
88	cytidine deamination (GO:0009972)	2.51623275
89	cytidine metabolic process (GO:0046087)	2.51623275
90	cytidine catabolic process (GO:0006216)	2.51623275
91	iron coordination entity transport (GO:1901678)	2.51565215
92	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.51491574
93	sterol biosynthetic process (GO:0016126)	2.51480065
94	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.50858474
95	UTP metabolic process (GO:0046051)	2.49397110
96	isoprenoid biosynthetic process (GO:0008299)	2.48661624
97	rhodopsin mediated signaling pathway (GO:0016056)	2.44142796
98	regulation of telomere maintenance (GO:0032204)	2.43375832
99	seminiferous tubule development (GO:0072520)	2.42275729
100	mannosylation (GO:0097502)	2.42079529

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.26280210
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.61680290
3	VDR_22108803_ChIP-Seq_LS180_Human	2.81256199
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53249689
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47249808
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.42659636
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.39138176
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34394777
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27985566
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15640746
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.08495672
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.05645610
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03749620
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.02871326
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.00857516
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.00497611
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.97152004
18	FUS_26573619_Chip-Seq_HEK293_Human	1.95781025
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95577347
20	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93632768
21	EWS_26573619_Chip-Seq_HEK293_Human	1.90099812
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.86796346
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.85402708
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.82700737
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.82700737
26	RNF2_27304074_Chip-Seq_NSC_Mouse	1.76585129
27	P300_19829295_ChIP-Seq_ESCs_Human	1.75375333
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71129092
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.70823459
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65445436
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.65037021
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.61904106
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61087758
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.59518173
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57817781
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56969540
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56206973
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52501174
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.52494802
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.51502105
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.51179057
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49549480
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.48584471
44	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.43485561
45	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.37795517
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35932211
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.35932211
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32923950
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30821954
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30367031
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25972447
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25581533
53	AR_25329375_ChIP-Seq_VCAP_Human	1.25571143
54	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.25230120
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.20874223
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.20809892
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.18127698
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17106869
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16821570
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.16589968
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15960776
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15960776
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15852678
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15393235
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15393235
66	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.15216676
67	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13884135
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13100822
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12741362
70	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11639634
71	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10814534
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08682421
73	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.08288856
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07946585
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07825939
76	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07124830
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06525287
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06253496
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05259794
80	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05237874
81	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04843522
82	AR_20517297_ChIP-Seq_VCAP_Human	1.04832318
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04588436
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02964307
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.02484994
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02332845
87	NCOR_22424771_ChIP-Seq_293T_Human	1.01185277
88	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00923149
89	STAT3_23295773_ChIP-Seq_U87_Human	1.00700730
90	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.00232778
91	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99891247
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99156531
93	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98909626
94	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.98221723
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97010619
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96919148
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96405027
98	TCF4_23295773_ChIP-Seq_U87_Human	0.95276074
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94841300
100	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94724421

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.75312679
2	MP0003787_abnormal_imprinting	3.39547726
3	MP0002653_abnormal_ependyma_morphology	2.87859106
4	MP0002638_abnormal_pupillary_reflex	2.41675249
5	MP0003122_maternal_imprinting	2.40811746
6	MP0008789_abnormal_olfactory_epithelium	2.35766586
7	MP0002938_white_spotting	2.35090854
8	MP0005084_abnormal_gallbladder_morpholo	2.29569795
9	MP0008877_abnormal_DNA_methylation	2.25901903
10	MP0003121_genomic_imprinting	2.20553251
11	MP0006276_abnormal_autonomic_nervous	2.04966932
12	MP0005394_taste/olfaction_phenotype	2.04187794
13	MP0005499_abnormal_olfactory_system	2.04187794
14	MP0004142_abnormal_muscle_tone	2.00671021
15	MP0005551_abnormal_eye_electrophysiolog	1.98587316
16	MP0003195_calcinosis	1.97546899
17	MP0006072_abnormal_retinal_apoptosis	1.93515551
18	MP0000372_irregular_coat_pigmentation	1.88353968
19	MP0002163_abnormal_gland_morphology	1.87352128
20	MP0005645_abnormal_hypothalamus_physiol	1.85160997
21	MP0003136_yellow_coat_color	1.83323938
22	MP0002102_abnormal_ear_morphology	1.82878873
23	MP0001984_abnormal_olfaction	1.79818194
24	MP0003880_abnormal_central_pattern	1.77206313
25	MP0000569_abnormal_digit_pigmentation	1.72501212
26	MP0000778_abnormal_nervous_system	1.64435803
27	MP0001968_abnormal_touch/_nociception	1.62343782
28	MP0002272_abnormal_nervous_system	1.62034821
29	MP0000631_abnormal_neuroendocrine_gland	1.60772362
30	MP0001485_abnormal_pinna_reflex	1.58444527
31	MP0005646_abnormal_pituitary_gland	1.57848291
32	MP0005379_endocrine/exocrine_gland_phen	1.54705561
33	MP0009745_abnormal_behavioral_response	1.53514520
34	MP0001529_abnormal_vocalization	1.53015979
35	MP0002928_abnormal_bile_duct	1.49154859
36	MP0003011_delayed_dark_adaptation	1.46752680
37	MP0002557_abnormal_social/conspecific_i	1.46392235
38	MP0004885_abnormal_endolymph	1.45574081
39	MP0001986_abnormal_taste_sensitivity	1.45192881
40	MP0009046_muscle_twitch	1.43414436
41	MP0005253_abnormal_eye_physiology	1.43297735
42	MP0004133_heterotaxia	1.41863716
43	MP0002138_abnormal_hepatobiliary_system	1.41413696
44	MP0002733_abnormal_thermal_nociception	1.39881888
45	MP0001905_abnormal_dopamine_level	1.35021220
46	MP0002572_abnormal_emotion/affect_behav	1.34474412
47	MP0001293_anophthalmia	1.34290146
48	MP0008872_abnormal_physiological_respon	1.31743514
49	MP0002277_abnormal_respiratory_mucosa	1.31184113
50	MP0003283_abnormal_digestive_organ	1.29075340
51	MP0002184_abnormal_innervation	1.25872883
52	MP0002837_dystrophic_cardiac_calcinosis	1.24803713
53	MP0001970_abnormal_pain_threshold	1.24375052
54	MP0004742_abnormal_vestibular_system	1.22681314
55	MP0003123_paternal_imprinting	1.21527360
56	MP0005195_abnormal_posterior_eye	1.19441830
57	MP0002752_abnormal_somatic_nervous	1.18506016
58	MP0008875_abnormal_xenobiotic_pharmacok	1.16276562
59	MP0002751_abnormal_autonomic_nervous	1.15544174
60	MP0003635_abnormal_synaptic_transmissio	1.13993790
61	MP0005423_abnormal_somatic_nervous	1.12808094
62	MP0002063_abnormal_learning/memory/cond	1.11726757
63	MP0000427_abnormal_hair_cycle	1.11696801
64	MP0002876_abnormal_thyroid_physiology	1.08950607
65	MP0001919_abnormal_reproductive_system	1.08893025
66	MP0001188_hyperpigmentation	1.08567119
67	MP0001486_abnormal_startle_reflex	1.07958781
68	MP0002064_seizures	1.07865906
69	MP0005389_reproductive_system_phenotype	1.05845025
70	MP0003646_muscle_fatigue	1.03181749
71	MP0003878_abnormal_ear_physiology	1.02315385
72	MP0005377_hearing/vestibular/ear_phenot	1.02315385
73	MP0002067_abnormal_sensory_capabilities	1.01012740
74	MP0002736_abnormal_nociception_after	0.99464884
75	MP0002160_abnormal_reproductive_system	0.99217297
76	MP0001440_abnormal_grooming_behavior	0.96409041
77	MP0000955_abnormal_spinal_cord	0.96126503
78	MP0000026_abnormal_inner_ear	0.94632324
79	MP0002734_abnormal_mechanical_nocicepti	0.93103031
80	MP0003890_abnormal_embryonic-extraembry	0.92913373
81	MP0009379_abnormal_foot_pigmentation	0.89743046
82	MP0005391_vision/eye_phenotype	0.88119972
83	MP0002882_abnormal_neuron_morphology	0.86873909
84	MP0001501_abnormal_sleep_pattern	0.86234391
85	MP0004043_abnormal_pH_regulation	0.82133435
86	MP0002735_abnormal_chemical_nociception	0.81494760
87	MP0001286_abnormal_eye_development	0.80518223
88	MP0000049_abnormal_middle_ear	0.80223703
89	MP0001944_abnormal_pancreas_morphology	0.78535640
90	MP0002095_abnormal_skin_pigmentation	0.78217457
91	MP0002234_abnormal_pharynx_morphology	0.77391998
92	MP0001324_abnormal_eye_pigmentation	0.74910684
93	MP0004859_abnormal_synaptic_plasticity	0.74895205
94	MP0002210_abnormal_sex_determination	0.74703680
95	MP0005410_abnormal_fertilization	0.73805740
96	MP0003567_abnormal_fetal_cardiomyocyte	0.73614935
97	MP0001963_abnormal_hearing_physiology	0.72970238
98	MP0002909_abnormal_adrenal_gland	0.72595887
99	MP0000230_abnormal_systemic_arterial	0.70758659
100	MP0003119_abnormal_digestive_system	0.70278898

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	3.95944994
2	Molar tooth sign on MRI (HP:0002419)	3.95944994
3	Pancreatic cysts (HP:0001737)	3.75874718
4	True hermaphroditism (HP:0010459)	3.75504755
5	Medial flaring of the eyebrow (HP:0010747)	3.69921404
6	Pancreatic fibrosis (HP:0100732)	3.69542991
7	Nephronophthisis (HP:0000090)	3.68597423
8	Acute necrotizing encephalopathy (HP:0006965)	3.66288466
9	Congenital stationary night blindness (HP:0007642)	3.23599804
10	Abnormal ciliary motility (HP:0012262)	3.23062021
11	Progressive macrocephaly (HP:0004481)	3.18349953
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.15519963
13	Gait imbalance (HP:0002141)	3.14173936
14	Mitochondrial inheritance (HP:0001427)	3.09155049
15	Acute encephalopathy (HP:0006846)	3.05003786
16	Congenital primary aphakia (HP:0007707)	2.99251265
17	Abnormality of the labia minora (HP:0012880)	2.92856283
18	Abnormality of the renal medulla (HP:0100957)	2.92666208
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.91028504
20	Nephrogenic diabetes insipidus (HP:0009806)	2.90150517
21	Increased CSF lactate (HP:0002490)	2.64721926
22	Sclerocornea (HP:0000647)	2.63586779
23	Septo-optic dysplasia (HP:0100842)	2.62698289
24	Hyperglycinemia (HP:0002154)	2.60655504
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.60205570
26	Abnormal respiratory motile cilium physiology (HP:0012261)	2.58873592
27	Increased hepatocellular lipid droplets (HP:0006565)	2.48863583
28	Abolished electroretinogram (ERG) (HP:0000550)	2.44048478
29	Congenital, generalized hypertrichosis (HP:0004540)	2.40366547
30	Hepatocellular necrosis (HP:0001404)	2.37400468
31	Cystic liver disease (HP:0006706)	2.35923476
32	Hepatic necrosis (HP:0002605)	2.35872697
33	Vaginal atresia (HP:0000148)	2.31331126
34	Genital tract atresia (HP:0001827)	2.31199123
35	3-Methylglutaconic aciduria (HP:0003535)	2.28346832
36	Optic disc pallor (HP:0000543)	2.28200517
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.27938863
38	Lipid accumulation in hepatocytes (HP:0006561)	2.24583740
39	Abnormal number of erythroid precursors (HP:0012131)	2.18197515
40	Methylmalonic acidemia (HP:0002912)	2.17887248
41	Lissencephaly (HP:0001339)	2.17775820
42	Rib fusion (HP:0000902)	2.16721880
43	Polyphagia (HP:0002591)	2.13457137
44	Pendular nystagmus (HP:0012043)	2.12023871
45	Poor coordination (HP:0002370)	2.11446503
46	Cerebral edema (HP:0002181)	2.10600745
47	Abnormality of the renal cortex (HP:0011035)	2.09771378
48	Attenuation of retinal blood vessels (HP:0007843)	2.08165516
49	Myokymia (HP:0002411)	2.08129826
50	Renal Fanconi syndrome (HP:0001994)	2.07615227
51	Optic nerve hypoplasia (HP:0000609)	2.07403310
52	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06442417
53	Colon cancer (HP:0003003)	2.06253296
54	Growth hormone deficiency (HP:0000824)	2.05974767
55	Anencephaly (HP:0002323)	2.04911973
56	Male pseudohermaphroditism (HP:0000037)	2.03541748
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.01664569
58	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00688903
59	Hypoplasia of the fovea (HP:0007750)	2.00688903
60	Type II lissencephaly (HP:0007260)	2.00274656
61	Congenital hepatic fibrosis (HP:0002612)	1.99488679
62	Intestinal atresia (HP:0011100)	1.99122272
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98683398
64	Absent/shortened dynein arms (HP:0200106)	1.98683398
65	Tubular atrophy (HP:0000092)	1.97321440
66	Pachygyria (HP:0001302)	1.97200066
67	Dyskinesia (HP:0100660)	1.96881371
68	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.96736647
69	Postaxial foot polydactyly (HP:0001830)	1.96351475
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93940971
71	Large for gestational age (HP:0001520)	1.93574788
72	Specific learning disability (HP:0001328)	1.93308236
73	Narrow forehead (HP:0000341)	1.93088472
74	Abnormality of urine glucose concentration (HP:0011016)	1.93077306
75	Glycosuria (HP:0003076)	1.93077306
76	Abnormal drinking behavior (HP:0030082)	1.92069244
77	Polydipsia (HP:0001959)	1.92069244
78	Poor suck (HP:0002033)	1.90424323
79	Macrocytic anemia (HP:0001972)	1.89762302
80	Hyperventilation (HP:0002883)	1.89094077
81	Methylmalonic aciduria (HP:0012120)	1.88704769
82	Postaxial hand polydactyly (HP:0001162)	1.88667922
83	Abnormality of the pons (HP:0007361)	1.88651002
84	Hypoplasia of the pons (HP:0012110)	1.87651859
85	Limb dystonia (HP:0002451)	1.86549630
86	Constricted visual fields (HP:0001133)	1.83742291
87	Exertional dyspnea (HP:0002875)	1.80047004
88	Chronic hepatic failure (HP:0100626)	1.77487513
89	Anophthalmia (HP:0000528)	1.76234354
90	Decreased central vision (HP:0007663)	1.76191195
91	Retinitis pigmentosa (HP:0000510)	1.76139534
92	Absent thumb (HP:0009777)	1.75933630
93	Abnormal respiratory epithelium morphology (HP:0012253)	1.75908297
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.75908297
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75831761
96	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74790535
97	Abnormality of glycine metabolism (HP:0010895)	1.74790535
98	Furrowed tongue (HP:0000221)	1.72898618
99	Abnormal hair whorl (HP:0010721)	1.70881990
100	Reticulocytopenia (HP:0001896)	1.70698493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	3.22176784
2	FRK	3.10065653
3	WNK3	3.08274794
4	BMPR1B	2.83298835
5	STK16	2.75645716
6	ADRBK2	2.64297001
7	TAOK3	2.56036087
8	INSRR	2.42149144
9	WNK4	2.41764141
10	VRK2	2.27067344
11	DYRK2	2.20534601
12	ZAK	2.18172349
13	GRK1	2.08919969
14	NUAK1	2.05879907
15	MAP4K2	1.98980068
16	MAPK15	1.86522007
17	VRK1	1.76714696
18	MAPK13	1.76605029
19	CASK	1.75642581
20	TSSK6	1.64302086
21	TXK	1.62372760
22	PINK1	1.50044560
23	NTRK3	1.44843347
24	TLK1	1.43779353
25	WEE1	1.40514413
26	BCKDK	1.39281150
27	TRIM28	1.32914989
28	PRKCG	1.32328355
29	STK39	1.30252879
30	MAP3K4	1.30193756
31	MAP2K7	1.28901286
32	NTRK2	1.19717223
33	MARK1	1.19260158
34	EPHB1	1.17689604
35	TNIK	1.16286761
36	NME1	1.00188845
37	PASK	0.98980918
38	CAMKK2	0.96395406
39	OXSR1	0.90540019
40	TYRO3	0.85633821
41	PAK3	0.85342316
42	PRKCQ	0.84831633
43	DYRK1B	0.84049590
44	MAP2K2	0.83285709
45	TNK2	0.81755267
46	PRKD3	0.81537707
47	MKNK2	0.80984072
48	MINK1	0.80044802
49	RPS6KA5	0.79564231
50	DYRK3	0.79435287
51	PLK3	0.78963157
52	EPHA4	0.77197163
53	PLK4	0.76073689
54	BCR	0.74063592
55	CSNK1G2	0.68037939
56	DAPK2	0.66307764
57	CSNK1G1	0.66274825
58	TGFBR1	0.66169918
59	PLK2	0.65360447
60	ADRBK1	0.63542473
61	CSNK1G3	0.61487681
62	BRAF	0.61262660
63	PTK2B	0.59925423
64	FGFR2	0.58430416
65	PRKCE	0.57575330
66	CDC7	0.55993908
67	PRKACA	0.55125309
68	CAMK1	0.51256925
69	PIK3CA	0.49485291
70	SGK494	0.49262301
71	SGK223	0.49262301
72	TAF1	0.47616395
73	GRK7	0.47326365
74	PKN1	0.46830225
75	PHKG2	0.46502561
76	PHKG1	0.46502561
77	CSNK1A1	0.45913099
78	ERBB3	0.45257801
79	EPHB2	0.44921712
80	IKBKB	0.44815012
81	CAMK2A	0.44741032
82	CDK3	0.44378416
83	SGK2	0.44133293
84	ACVR1B	0.44081220
85	BRSK2	0.41824557
86	CSNK1A1L	0.39457337
87	SIK2	0.39404220
88	CDK8	0.38583009
89	STK11	0.38540710
90	MAPKAPK5	0.38220421
91	PRKCZ	0.37562192
92	TIE1	0.36932222
93	MKNK1	0.36312952
94	CDK19	0.36228438
95	MAP3K11	0.35970816
96	ITK	0.35298629
97	KIT	0.35269941
98	HIPK2	0.34223152
99	MUSK	0.33553548
100	CAMK1G	0.32621167

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65430976
2	Steroid biosynthesis_Homo sapiens_hsa00100	2.99988057
3	Parkinsons disease_Homo sapiens_hsa05012	2.91775061
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.89421691
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.75678805
6	Ribosome_Homo sapiens_hsa03010	2.69971496
7	Protein export_Homo sapiens_hsa03060	2.66638862
8	Phototransduction_Homo sapiens_hsa04744	2.55518499
9	Butanoate metabolism_Homo sapiens_hsa00650	2.38227581
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.28859233
11	RNA polymerase_Homo sapiens_hsa03020	2.21158500
12	Nicotine addiction_Homo sapiens_hsa05033	2.19986228
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10824982
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10753107
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90333857
16	Huntingtons disease_Homo sapiens_hsa05016	1.86818150
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.82153979
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79684450
19	Alzheimers disease_Homo sapiens_hsa05010	1.77474591
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.69502180
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68432248
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.67121934
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.59709703
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55327338
25	Homologous recombination_Homo sapiens_hsa03440	1.53238229
26	Proteasome_Homo sapiens_hsa03050	1.40646124
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.37500175
28	RNA degradation_Homo sapiens_hsa03018	1.31860795
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28632634
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25647565
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21527939
32	Peroxisome_Homo sapiens_hsa04146	1.14501771
33	Propanoate metabolism_Homo sapiens_hsa00640	1.12608159
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.11815004
35	Basal transcription factors_Homo sapiens_hsa03022	1.06910052
36	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.06684641
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06251528
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.05043406
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.04670300
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04003740
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.01940788
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00359661
43	Morphine addiction_Homo sapiens_hsa05032	0.93679129
44	GABAergic synapse_Homo sapiens_hsa04727	0.92568720
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91242627
46	Olfactory transduction_Homo sapiens_hsa04740	0.89783203
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.89457637
48	Caffeine metabolism_Homo sapiens_hsa00232	0.89351575
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88173858
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86338672
51	Asthma_Homo sapiens_hsa05310	0.84441503
52	Insulin secretion_Homo sapiens_hsa04911	0.83909569
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82685829
54	Taste transduction_Homo sapiens_hsa04742	0.82620795
55	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81446742
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80120554
57	One carbon pool by folate_Homo sapiens_hsa00670	0.79524891
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79314208
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.74233371
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73592748
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.72476759
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.71974348
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71473308
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70268740
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69559524
66	Purine metabolism_Homo sapiens_hsa00230	0.68136923
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66965021
68	Folate biosynthesis_Homo sapiens_hsa00790	0.66871594
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66476045
70	Metabolic pathways_Homo sapiens_hsa01100	0.64521236
71	Sulfur relay system_Homo sapiens_hsa04122	0.64233174
72	Retinol metabolism_Homo sapiens_hsa00830	0.64164818
73	Serotonergic synapse_Homo sapiens_hsa04726	0.63076369
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62862017
75	Cocaine addiction_Homo sapiens_hsa05030	0.61709610
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56441374
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56188082
78	Allograft rejection_Homo sapiens_hsa05330	0.55095483
79	Regulation of autophagy_Homo sapiens_hsa04140	0.54106384
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53315179
81	Fatty acid elongation_Homo sapiens_hsa00062	0.53010685
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52665020
83	Mismatch repair_Homo sapiens_hsa03430	0.52306498
84	Circadian entrainment_Homo sapiens_hsa04713	0.51950640
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51682600
86	Mineral absorption_Homo sapiens_hsa04978	0.49859677
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49462205
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49166598
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47368910
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.46354795
91	Dopaminergic synapse_Homo sapiens_hsa04728	0.45526113
92	Amphetamine addiction_Homo sapiens_hsa05031	0.39535367
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38363627
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.37660626
95	Axon guidance_Homo sapiens_hsa04360	0.37156888
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.36125820
97	ABC transporters_Homo sapiens_hsa02010	0.35903729
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.35813730
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33105503
100	Spliceosome_Homo sapiens_hsa03040	0.30370435

HSD17B7P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »