HSD3B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate gland growth (GO:0060736)9.81396700
2* estrogen metabolic process (GO:0008210)9.04165723
3ketone biosynthetic process (GO:0042181)8.84208152
4cellular response to antibiotic (GO:0071236)8.71510914
5cellular response to gonadotropin stimulus (GO:0071371)8.57513747
6* glucocorticoid biosynthetic process (GO:0006704)8.34729299
7regulation of gonadotropin secretion (GO:0032276)8.33571683
8* hormone biosynthetic process (GO:0042446)8.20731519
9mating behavior (GO:0007617)8.05634846
10multi-multicellular organism process (GO:0044706)8.00687589
11* glucocorticoid metabolic process (GO:0008211)7.91950179
12* androgen metabolic process (GO:0008209)7.72943611
13cellular response to interferon-alpha (GO:0035457)7.34766056
14multi-organism reproductive process (GO:0044703)6.99166203
15response to insecticide (GO:0017085)6.87323848
16positive regulation of growth hormone secretion (GO:0060124)6.68503654
17adhesion of symbiont to host (GO:0044406)6.35224482
18cellular response to toxic substance (GO:0097237)6.15751776
19response to gonadotropin (GO:0034698)6.10203593
20vitamin transmembrane transport (GO:0035461)6.10141105
21response to phenylpropanoid (GO:0080184)6.01972979
22cellular response to growth hormone stimulus (GO:0071378)5.89125976
23Leydig cell differentiation (GO:0033327)5.84897642
24vitamin D metabolic process (GO:0042359)5.79554037
25negative regulation of macrophage differentiation (GO:0045650)5.64980152
26response to leptin (GO:0044321)5.61920315
27response to vitamin E (GO:0033197)5.48782762
28cellular response to zinc ion (GO:0071294)5.42146328
29positive regulation of male gonad development (GO:2000020)5.36825013
30regulation of male gonad development (GO:2000018)5.20150630
31endocrine hormone secretion (GO:0060986)5.10833235
32benzene-containing compound metabolic process (GO:0042537)5.09308030
33hemoglobin metabolic process (GO:0020027)5.02846904
34cytokine metabolic process (GO:0042107)5.01112110
35epoxygenase P450 pathway (GO:0019373)4.90125923
36sex determination (GO:0007530)4.81911987
37myoblast fusion (GO:0007520)4.78694780
38positive regulation of protein kinase C signaling (GO:0090037)4.74413074
39toxin metabolic process (GO:0009404)4.74279635
40syncytium formation (GO:0006949)4.70736143
41regulation of growth hormone secretion (GO:0060123)4.68113933
42response to corticosterone (GO:0051412)4.67756919
43diacylglycerol metabolic process (GO:0046339)4.50322749
44JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.42366705
45regulation of sequestering of triglyceride (GO:0010889)4.31675665
46cellular response to epinephrine stimulus (GO:0071872)4.30644623
47low-density lipoprotein particle clearance (GO:0034383)4.30060621
48collecting duct development (GO:0072044)4.28332293
49sphingoid metabolic process (GO:0046519)4.19911937
50syncytium formation by plasma membrane fusion (GO:0000768)4.19777331
51response to lead ion (GO:0010288)4.17693008
52cellular ketone metabolic process (GO:0042180)4.08270798
53positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.03234682
54regulation of female gonad development (GO:2000194)4.01181346
55lymphangiogenesis (GO:0001946)3.94133082
56* steroid biosynthetic process (GO:0006694)3.82245801
57phagocytosis, recognition (GO:0006910)3.80933868
58seminiferous tubule development (GO:0072520)3.79099568
59response to cadmium ion (GO:0046686)3.78063968
60response to mineralocorticoid (GO:0051385)3.77210678
61bundle of His cell to Purkinje myocyte communication (GO:0086069)3.73568580
62NADP metabolic process (GO:0006739)3.71506316
63vascular endothelial growth factor signaling pathway (GO:0038084)3.68532497
64phospholipid homeostasis (GO:0055091)3.67922047
65ovarian follicle development (GO:0001541)3.65101253
66* cellular hormone metabolic process (GO:0034754)3.62186577
67fatty-acyl-CoA metabolic process (GO:0035337)3.53485296
68positive regulation of triglyceride biosynthetic process (GO:0010867)3.50463870
69negative regulation of activin receptor signaling pathway (GO:0032926)3.49138071
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47022245
71biotin metabolic process (GO:0006768)3.46168546
72triglyceride catabolic process (GO:0019433)3.45622011
73thioester biosynthetic process (GO:0035384)3.43043221
74acyl-CoA biosynthetic process (GO:0071616)3.43043221
75renal system process involved in regulation of blood volume (GO:0001977)3.41363897
76response to epinephrine (GO:0071871)3.39301040
77positive regulation of nitric-oxide synthase activity (GO:0051000)3.33744023
78triglyceride biosynthetic process (GO:0019432)3.33288038
79response to interferon-alpha (GO:0035455)3.32503748
80intracellular lipid transport (GO:0032365)3.32030342
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.30195355
82regulation of phospholipase A2 activity (GO:0032429)3.28416996
83myelin maintenance (GO:0043217)3.26957249
84regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.26303130
85brown fat cell differentiation (GO:0050873)3.25567923
86acylglycerol biosynthetic process (GO:0046463)3.25245297
87neutral lipid biosynthetic process (GO:0046460)3.25245297
88long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.24249209
89glyoxylate metabolic process (GO:0046487)3.23037377
90keratinocyte development (GO:0003334)3.20888775
91lipid storage (GO:0019915)3.19666058
92fatty acid homeostasis (GO:0055089)3.19563074
93bone morphogenesis (GO:0060349)3.18356490
94acylglycerol catabolic process (GO:0046464)3.17991762
95neutral lipid catabolic process (GO:0046461)3.17991762
96gonadal mesoderm development (GO:0007506)3.17826541
97uterus development (GO:0060065)3.17343440
98sterol catabolic process (GO:0016127)3.17147104
99cholesterol catabolic process (GO:0006707)3.17147104
100sterol metabolic process (GO:0016125)3.16162504
101glycerol metabolic process (GO:0006071)3.14997922
102fatty-acyl-CoA biosynthetic process (GO:0046949)3.14180817
103white fat cell differentiation (GO:0050872)3.08288036
104peroxisome fission (GO:0016559)3.07992282
105polarized epithelial cell differentiation (GO:0030859)3.07728070
106transcytosis (GO:0045056)3.07169915
107renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.05969547
108response to growth hormone (GO:0060416)3.04609361
109negative regulation of lipase activity (GO:0060192)3.03749571
110fatty acid transmembrane transport (GO:1902001)3.02827867
111* estrogen biosynthetic process (GO:0006703)20.8360627
112carnitine shuttle (GO:0006853)2.99511268
113regulation of steroid hormone biosynthetic process (GO:0090030)2.95934483
114regulation of cholesterol homeostasis (GO:2000188)2.95299641
115positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94651916
116high-density lipoprotein particle remodeling (GO:0034375)2.93845962
117basement membrane organization (GO:0071711)2.93633377
118apoptotic cell clearance (GO:0043277)2.91818185
119L-serine transport (GO:0015825)2.91378324
120ovulation cycle process (GO:0022602)2.90943698
121alditol metabolic process (GO:0019400)2.90595954
122parturition (GO:0007567)2.90402006
123regulation of cholesterol storage (GO:0010885)2.89921372
124cellular response to dexamethasone stimulus (GO:0071549)2.89116954
125regulation of steroid biosynthetic process (GO:0050810)2.87097369
126reverse cholesterol transport (GO:0043691)2.86114948
127multi-organism reproductive behavior (GO:0044705)2.82571806
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81886118
129heme transport (GO:0015886)2.81780768
130cholesterol metabolic process (GO:0008203)2.81528842
131lymph vessel development (GO:0001945)2.81280208
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80888384
133phospholipid efflux (GO:0033700)2.79563613
134very long-chain fatty acid metabolic process (GO:0000038)2.79466133
135desmosome organization (GO:0002934)2.79077469
136vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.74112654
137response to dexamethasone (GO:0071548)2.72792717
138amino-acid betaine transport (GO:0015838)2.71933222
139carnitine transport (GO:0015879)2.71933222
140lipoprotein metabolic process (GO:0042157)2.70507510
141urea cycle (GO:0000050)2.69848220
142L-alpha-amino acid transmembrane transport (GO:1902475)2.69188887
143cellular response to lithium ion (GO:0071285)2.68440020
144reproductive behavior (GO:0019098)2.67229649
145regulation of cholesterol esterification (GO:0010872)2.65782479
146carnitine transmembrane transport (GO:1902603)2.65680886
147NADPH regeneration (GO:0006740)2.64014851
148sterol transport (GO:0015918)2.62216461
149cholesterol transport (GO:0030301)2.62216461
150* hormone metabolic process (GO:0042445)2.62209903
151NADH metabolic process (GO:0006734)2.62146477
152negative regulation of fatty acid transport (GO:2000192)2.61866387
153plasma lipoprotein particle clearance (GO:0034381)2.61474335
154negative regulation of smooth muscle cell differentiation (GO:0051151)2.60574311
155detection of molecule of bacterial origin (GO:0032490)2.59967719
156response to salt stress (GO:0009651)2.58954605
157multicellular organismal aging (GO:0010259)2.58521894
158regulation of interferon-gamma biosynthetic process (GO:0045072)2.58478163
159maternal process involved in female pregnancy (GO:0060135)2.58401287
160positive regulation of cholesterol efflux (GO:0010875)2.57966956
161T-helper 1 type immune response (GO:0042088)2.57469993
162protein neddylation (GO:0045116)2.57288592
163positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.55040407
164sprouting angiogenesis (GO:0002040)2.54573579
165positive regulation of reproductive process (GO:2000243)2.53644657
166cellular response to cAMP (GO:0071320)2.52285613
167male gonad development (GO:0008584)2.50495887
168alpha-linolenic acid metabolic process (GO:0036109)2.48988175
169phenylpropanoid metabolic process (GO:0009698)2.46992109
170tricarboxylic acid metabolic process (GO:0072350)2.46068760
171bile acid biosynthetic process (GO:0006699)2.45938064
172cellular response to metal ion (GO:0071248)2.45865172
173female gonad development (GO:0008585)2.45202418
174cholesterol efflux (GO:0033344)2.44025249
175embryonic eye morphogenesis (GO:0048048)2.41732448
176C21-steroid hormone biosynthetic process (GO:0006700)17.3210749
177cellular response to cadmium ion (GO:0071276)15.4768511
178* androgen biosynthetic process (GO:0006702)14.8845973
179cellular response to follicle-stimulating hormone stimulus (GO:0071372)14.7542694
180progesterone metabolic process (GO:0042448)11.4321669
181C21-steroid hormone metabolic process (GO:0008207)11.2041983
182female pregnancy (GO:0007565)10.9680383
183response to follicle-stimulating hormone (GO:0032354)10.8742161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human9.07927675
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.75625050
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.27661765
4CLOCK_20551151_ChIP-Seq_293T_Human4.97435750
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.85797577
6ESR1_15608294_ChIP-ChIP_MCF-7_Human4.50943660
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.68431567
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.44866151
9SRY_22984422_ChIP-ChIP_TESTIS_Rat3.39598900
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.88532754
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.75527852
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.63887168
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57599149
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.55132334
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.50018849
16AHR_22903824_ChIP-Seq_MCF-7_Human2.43386414
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39272423
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.38139866
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.36361068
20TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.32293899
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19699077
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.17063291
23* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.05219245
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99930976
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94333215
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92229619
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.86676001
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86659151
29TP53_18474530_ChIP-ChIP_U2OS_Human1.83961783
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83914695
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83467132
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.78999038
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77823773
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76891882
35* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.75001545
36GATA3_24758297_ChIP-Seq_MCF-7_Human1.74949130
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74750263
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69376683
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67879273
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65224866
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64342122
42PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.62900003
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58504343
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58504343
45LXR_22292898_ChIP-Seq_THP-1_Human1.54874947
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53252421
47* GATA4_25053715_ChIP-Seq_YYC3_Human1.52559894
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.52372044
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50001950
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45894919
51KDM2B_26808549_Chip-Seq_DND41_Human1.44654615
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43915400
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43508385
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.43348312
55STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.41728908
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37603896
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.36188402
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35567537
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35320923
60KDM2B_26808549_Chip-Seq_K562_Human1.32683454
61BRD4_25478319_ChIP-Seq_HGPS_Human1.30073133
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28819205
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28587676
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26158765
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25965881
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23480756
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.22805961
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19890937
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19366335
70SCL_19346495_ChIP-Seq_HPC-7_Human1.18940867
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.17000386
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.16853382
73GATA1_19941826_ChIP-Seq_K562_Human1.15752247
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14955289
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14341131
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.12939312
77* TP63_23658742_ChIP-Seq_EP156T_Human1.12869681
78CJUN_26792858_Chip-Seq_BT549_Human1.11788544
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11639936
80VDR_24787735_ChIP-Seq_THP-1_Human1.10981204
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10872740
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10742472
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10652549
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10430972
85ZNF263_19887448_ChIP-Seq_K562_Human1.09364836
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.08210375
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.08055160
88TBX20_22080862_ChIP-Seq_HEART_Mouse1.06761295
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.06761295
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05777728
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04574502
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04567886
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04567886
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04283346
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03918329
96* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03768667
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03592274
98ERG_20517297_ChIP-Seq_VCAP_Human1.03359747
99CBP_20019798_ChIP-Seq_JUKART_Human1.03102894
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03102894
101ISL1_27105846_Chip-Seq_CPCs_Mouse1.02666165
102P300_19829295_ChIP-Seq_ESCs_Human1.02543412
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02486430
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01298633
105RACK7_27058665_Chip-Seq_MCF-7_Human1.00798715
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00784702
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99811622
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.99725050
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98762689
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98528869
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97875811
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97192704
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96818438
114FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95737995
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95203341
116SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94830104
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.94661472
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94654544
119TP63_22573176_ChIP-Seq_HFKS_Human0.93676701
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93626975
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93588736
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91785913
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91529827
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91529827
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91500027
126ZNF274_21170338_ChIP-Seq_K562_Hela0.90681482
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90192130
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89303323
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89022643
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88461982
131EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88431611
132* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88262036
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88166345
134EGR1_19032775_ChIP-ChIP_M12_Human0.87998322
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85999451
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85832383
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.85311381
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.85157512
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84982729
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84425726
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.84213665
142AR_21572438_ChIP-Seq_LNCaP_Human0.83810260
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.83459079
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82860879
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.82428221
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80822334
147* GATA6_25053715_ChIP-Seq_YYC3_Human0.80424167
148RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80303985
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79954651
150PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79142500
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79085114
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78722868
153* SOX2_20726797_ChIP-Seq_SW620_Human0.77867745
154AR_21909140_ChIP-Seq_LNCAP_Human0.77815611
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.77676966
156CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77543598
157KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77375539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland8.87687701
2MP0009697_abnormal_copulation8.73167126
3MP0000639_abnormal_adrenal_gland7.28887171
4MP0005647_abnormal_sex_gland4.97989188
5MP0002163_abnormal_gland_morphology4.54815717
6MP0001661_extended_life_span4.30384320
7MP0003195_calcinosis4.05400381
8MP0005379_endocrine/exocrine_gland_phen3.74996104
9MP0006276_abnormal_autonomic_nervous3.40395405
10MP0002971_abnormal_brown_adipose3.22214624
11MP0001919_abnormal_reproductive_system3.16726271
12MP0005670_abnormal_white_adipose3.03316417
13MP0003315_abnormal_perineum_morphology3.02429934
14MP0002876_abnormal_thyroid_physiology3.01814959
15MP0005187_abnormal_penis_morphology2.96028856
16MP0003941_abnormal_skin_development2.84880484
17MP0004019_abnormal_vitamin_homeostasis2.84182646
18MP0001765_abnormal_ion_homeostasis2.81382454
19MP0004185_abnormal_adipocyte_glucose2.73274567
20MP0005666_abnormal_adipose_tissue2.67296496
21MP0005389_reproductive_system_phenotype2.63325293
22MP0001666_abnormal_nutrient_absorption2.43948169
23MP0005375_adipose_tissue_phenotype2.42125931
24MP0009115_abnormal_fat_cell2.35114912
25MP0000003_abnormal_adipose_tissue2.34658433
26MP0003959_abnormal_lean_body2.31207680
27MP0008995_early_reproductive_senescence2.21503526
28MP0000013_abnormal_adipose_tissue2.21380655
29MP0010329_abnormal_lipoprotein_level2.15143647
30MP0000647_abnormal_sebaceous_gland2.11133342
31MP0005636_abnormal_mineral_homeostasis2.10360162
32MP0001440_abnormal_grooming_behavior2.04576250
33MP0010368_abnormal_lymphatic_system2.02644326
34MP0008438_abnormal_cutaneous_collagen2.01303475
35MP0009384_cardiac_valve_regurgitation2.00504201
36MP0000230_abnormal_systemic_arterial1.89592470
37MP0008875_abnormal_xenobiotic_pharmacok1.83879777
38MP0009840_abnormal_foam_cell1.83453479
39MP0004883_abnormal_blood_vessel1.78254527
40MP0006035_abnormal_mitochondrial_morpho1.68976318
41MP0003953_abnormal_hormone_level1.66739051
42MP0002139_abnormal_hepatobiliary_system1.61272218
43MP0001119_abnormal_female_reproductive1.61199479
44MP0000631_abnormal_neuroendocrine_gland1.59814098
45MP0009703_decreased_birth_body1.49438058
46MP0004782_abnormal_surfactant_physiolog1.47501501
47MP0004264_abnormal_extraembryonic_tissu1.43410857
48MP0004084_abnormal_cardiac_muscle1.36864283
49MP0000538_abnormal_urinary_bladder1.32807422
50MP0002254_reproductive_system_inflammat1.30486738
51MP0005503_abnormal_tendon_morphology1.28723228
52MP0009278_abnormal_bone_marrow1.27827565
53MP0010234_abnormal_vibrissa_follicle1.27063545
54MP0009780_abnormal_chondrocyte_physiolo1.25499071
55MP0002160_abnormal_reproductive_system1.24377671
56MP0002098_abnormal_vibrissa_morphology1.23517290
57MP0005319_abnormal_enzyme/_coenzyme1.22560733
58MP0005409_darkened_coat_color1.21832406
59MP0002269_muscular_atrophy1.21758181
60MP0005248_abnormal_Harderian_gland1.21721415
61MP0003283_abnormal_digestive_organ1.20839682
62MP0003699_abnormal_female_reproductive1.18082187
63MP0003453_abnormal_keratinocyte_physiol1.16719034
64MP0001881_abnormal_mammary_gland1.15059409
65MP0002822_catalepsy1.14542464
66MP0003011_delayed_dark_adaptation1.10001637
67MP0000653_abnormal_sex_gland1.08084354
68MP0003868_abnormal_feces_composition1.05958306
69MP0005452_abnormal_adipose_tissue1.04879617
70MP0005365_abnormal_bile_salt1.01887049
71MP0003300_gastrointestinal_ulcer1.01703395
72MP0005584_abnormal_enzyme/coenzyme_acti1.01286645
73MP0001340_abnormal_eyelid_morphology1.00141088
74MP0004036_abnormal_muscle_relaxation0.99938183
75MP0006054_spinal_hemorrhage0.98144910
76MP0002118_abnormal_lipid_homeostasis0.98106800
77MP0000613_abnormal_salivary_gland0.97160386
78MP0002210_abnormal_sex_determination0.96131964
79MP0009053_abnormal_anal_canal0.95359371
80MP0003638_abnormal_response/metabolism_0.95235606
81MP0002075_abnormal_coat/hair_pigmentati0.95174859
82MP0002970_abnormal_white_adipose0.94984791
83MP0004947_skin_inflammation0.93105415
84MP0001145_abnormal_male_reproductive0.92769401
85MP0003191_abnormal_cellular_cholesterol0.92575532
86MP0002796_impaired_skin_barrier0.90469625
87MP0005164_abnormal_response_to0.90414194
88MP0005535_abnormal_body_temperature0.89563642
89MP0002998_abnormal_bone_remodeling0.88518605
90MP0010386_abnormal_urinary_bladder0.88367954
91MP0000537_abnormal_urethra_morphology0.88287032
92MP0009672_abnormal_birth_weight0.87396137
93MP0003705_abnormal_hypodermis_morpholog0.83945414
94MP0009643_abnormal_urine_homeostasis0.83233167
95MP0002168_other_aberrant_phenotype0.82957455
96MP0003123_paternal_imprinting0.82606264
97MP0004272_abnormal_basement_membrane0.82318676
98MP0001851_eye_inflammation0.81850589
99MP0005332_abnormal_amino_acid0.81016686
100MP0000751_myopathy0.80673350
101MP0005023_abnormal_wound_healing0.80598302
102MP0003828_pulmonary_edema0.80093177
103MP0005623_abnormal_meninges_morphology0.77726622
104MP0001879_abnormal_lymphatic_vessel0.77111099
105MP0005058_abnormal_lysosome_morphology0.76627382
106MP0003936_abnormal_reproductive_system0.76131491
107MP0002896_abnormal_bone_mineralization0.75191571
108MP0003186_abnormal_redox_activity0.74742436
109MP0002078_abnormal_glucose_homeostasis0.74719670
110MP0005451_abnormal_body_composition0.74522578
111MP0010630_abnormal_cardiac_muscle0.73999307
112MP0004085_abnormal_heartbeat0.73418194
113MP0002009_preneoplasia0.72961832
114MP0006138_congestive_heart_failure0.72776078
115MP0010352_gastrointestinal_tract_polyps0.72522522
116MP0003115_abnormal_respiratory_system0.72206290
117MP0002972_abnormal_cardiac_muscle0.72029639
118MP0001756_abnormal_urination0.71927593
119MP0000367_abnormal_coat/_hair0.70477455
120MP0009642_abnormal_blood_homeostasis0.69993993
121MP0004147_increased_porphyrin_level0.69751429
122MP0002295_abnormal_pulmonary_circulatio0.69604084
123MP0003950_abnormal_plasma_membrane0.69557822
124MP0008004_abnormal_stomach_pH0.69387301
125MP0005085_abnormal_gallbladder_physiolo0.67410157
126MP0003279_aneurysm0.67387667
127MP0004381_abnormal_hair_follicle0.66992035
128MP0005334_abnormal_fat_pad0.65805449
129MP0000609_abnormal_liver_physiology0.64978181
130MP0003329_amyloid_beta_deposits0.64976623
131MP0001958_emphysema0.64659498
132MP0001186_pigmentation_phenotype0.64465055
133MP0000377_abnormal_hair_follicle0.63926437
134MP0001529_abnormal_vocalization0.63653402
135MP0003566_abnormal_cell_adhesion0.63261958
136MP0000343_altered_response_to0.63209306
137MP0004043_abnormal_pH_regulation0.62875465
138MP0004145_abnormal_muscle_electrophysio0.62860420
139MP0005385_cardiovascular_system_phenoty0.61855837
140MP0001544_abnormal_cardiovascular_syste0.61855837
141MP0001929_abnormal_gametogenesis0.61643793
142MP0005448_abnormal_energy_balance0.61606874
143MP0000383_abnormal_hair_follicle0.59977108
144MP0000604_amyloidosis0.59843551
145MP0002557_abnormal_social/conspecific_i0.59337746
146MP0005330_cardiomyopathy0.59142093
147MP0010678_abnormal_skin_adnexa0.59130222
148MP0000358_abnormal_cell_content/0.58581742
149MP0004130_abnormal_muscle_cell0.58039919
150MP0005275_abnormal_skin_tensile0.57826284
151MP0002128_abnormal_blood_circulation0.57434625
152MP0005646_abnormal_pituitary_gland0.56839997
153MP0002086_abnormal_extraembryonic_tissu0.56781510
154MP0000750_abnormal_muscle_regeneration0.54715397
155MP0000627_abnormal_mammary_gland0.54699249
156MP0008770_decreased_survivor_rate0.53167719
157MP0004087_abnormal_muscle_fiber0.52979007
158MP0001346_abnormal_lacrimal_gland0.51342348
159MP0009250_abnormal_appendicular_skeleto0.49637234
160MP0000598_abnormal_liver_morphology0.49472090
161MP0003385_abnormal_body_wall0.48621860
162MP0003091_abnormal_cell_migration0.48148783
163MP0002166_altered_tumor_susceptibility0.46172143
164MP0003567_abnormal_fetal_cardiomyocyte0.46126937
165MP0003122_maternal_imprinting0.46083210
166MP0004858_abnormal_nervous_system0.45011414
167MP0003942_abnormal_urinary_system0.44888206

Predicted human phenotypes

RankGene SetZ-score
1Hyperaldosteronism (HP:0000859)8.28366110
2Hyperpituitarism (HP:0010514)6.92700998
3Menstrual irregularities (HP:0000858)6.55195856
4Capillary hemangiomas (HP:0005306)6.18640930
5Premature ovarian failure (HP:0008209)5.99196339
6Decreased circulating renin level (HP:0003351)5.57148276
7Gonadal dysgenesis (HP:0000133)5.37467167
8Testicular neoplasm (HP:0010788)5.12748423
9Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.12014097
10Hypoplasia of the uterus (HP:0000013)4.87977349
11Upper limb muscle weakness (HP:0003484)4.77012668
12Muscle fibrillation (HP:0010546)4.68890462
13Tongue fasciculations (HP:0001308)4.63438106
14Adrenal overactivity (HP:0002717)4.53455671
15Abnormality of renin-angiotensin system (HP:0000847)4.31892215
16Azoospermia (HP:0000027)4.15039492
17Abnormal pupillary function (HP:0007686)4.09500276
18Bilateral sensorineural hearing impairment (HP:0008619)4.04768588
19Right ventricular cardiomyopathy (HP:0011663)4.04261656
20Abnormal auditory evoked potentials (HP:0006958)3.94591521
21Malnutrition (HP:0004395)3.91630726
22Macroorchidism (HP:0000053)3.89091850
23Aplasia/hypoplasia of the uterus (HP:0008684)3.87751942
24Neonatal onset (HP:0003623)3.79023380
25Multiple enchondromatosis (HP:0005701)3.77094205
26Increased circulating renin level (HP:0000848)3.76475570
27Lymphangioma (HP:0100764)3.63896749
28Proximal tubulopathy (HP:0000114)3.49895010
29Abnormality of the ischium (HP:0003174)3.47620540
30Rhabdomyolysis (HP:0003201)3.44494372
31Nonimmune hydrops fetalis (HP:0001790)3.43508016
32Accelerated skeletal maturation (HP:0005616)3.43381254
33Orthostatic hypotension (HP:0001278)3.18727453
34Abnormality of the common coagulation pathway (HP:0010990)3.17649113
35Spontaneous abortion (HP:0005268)3.16215729
36Secondary amenorrhea (HP:0000869)3.11851359
37Hypoglycemic coma (HP:0001325)2.94926819
38Abnormal spermatogenesis (HP:0008669)2.91931635
39Vacuolated lymphocytes (HP:0001922)2.88730865
40Anosmia (HP:0000458)2.85595330
41Congenital ichthyosiform erythroderma (HP:0007431)2.83778095
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80382844
43Myocardial infarction (HP:0001658)2.77443133
44Hyporeflexia of lower limbs (HP:0002600)2.76409304
45Precocious puberty (HP:0000826)2.76357836
46Abnormal pancreas size (HP:0012094)2.74353118
47Retinal atrophy (HP:0001105)2.69322961
48Gynecomastia (HP:0000771)2.61434781
49Bicornuate uterus (HP:0000813)2.59523952
50Disproportionate tall stature (HP:0001519)2.56099553
51Myoglobinuria (HP:0002913)2.55596937
52Absent eyebrow (HP:0002223)2.53501789
53Absent eyelashes (HP:0000561)2.49412776
54Pulmonary fibrosis (HP:0002206)2.48992300
55Hypoplasia of the iris (HP:0007676)2.47817855
56Subcapsular cataract (HP:0000523)2.45612775
57Infertility (HP:0000789)2.42295834
58Bilateral microphthalmos (HP:0007633)2.40256235
59Confusion (HP:0001289)2.38561507
60Growth hormone excess (HP:0000845)2.34974249
61Woolly hair (HP:0002224)2.34926212
62Neoplasm of the adrenal gland (HP:0100631)2.34768281
63Male pseudohermaphroditism (HP:0000037)2.31108873
64Impulsivity (HP:0100710)2.25675012
65Hyperlipoproteinemia (HP:0010980)2.24863381
66Abnormal cartilage morphology (HP:0002763)2.24845740
67Abnormality of pyrimidine metabolism (HP:0004353)2.23696419
68Hypoalphalipoproteinemia (HP:0003233)2.21359303
69Abnormality of fatty-acid metabolism (HP:0004359)2.21165154
70Abnormality of the parathyroid morphology (HP:0011766)2.19415775
71Exercise-induced myalgia (HP:0003738)2.13353295
72Abnormal hemoglobin (HP:0011902)2.12624858
73Abnormality of potassium homeostasis (HP:0011042)2.11988913
74Nausea (HP:0002018)2.11299154
75Difficulty walking (HP:0002355)2.11211948
76Visceral angiomatosis (HP:0100761)2.11135892
77Pigmentary retinal degeneration (HP:0001146)2.09734332
78Abnormality of the axillary hair (HP:0100134)2.09241461
79Abnormality of secondary sexual hair (HP:0009888)2.09241461
80Osteomalacia (HP:0002749)2.07571312
81Peripheral demyelination (HP:0011096)2.07275720
82Cardiovascular calcification (HP:0011915)2.07052689
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06237139
84Tetraparesis (HP:0002273)2.05379940
85Hyperammonemia (HP:0001987)2.03195170
86Wormian bones (HP:0002645)2.02714652
87Areflexia of lower limbs (HP:0002522)2.01288143
88Genu valgum (HP:0002857)2.01009763
89Exostoses (HP:0100777)2.00790189
90Ovarian neoplasm (HP:0100615)2.00214544
91Gonadotropin excess (HP:0000837)14.0626355
92Renal salt wasting (HP:0000127)11.0232236
93Abnormal sex determination (HP:0012244)10.8818168
94Sex reversal (HP:0012245)10.8818168
95Enlarged penis (HP:0000040)10.8765450
96Long palpebral fissure (HP:0000637)1.99597408
97Knee flexion contracture (HP:0006380)1.97175154
98Pili torti (HP:0003777)1.96371067
99Esophageal varix (HP:0002040)1.95423478
100Primary adrenal insufficiency (HP:0008207)1.94931093
101Aplasia of the musculature (HP:0100854)1.94769515
102Broad alveolar ridges (HP:0000187)1.94401863
103Hemangiomatosis (HP:0007461)1.94365987
104Aplasia involving bones of the extremities (HP:0009825)1.93456047
105Aplasia involving bones of the upper limbs (HP:0009823)1.93456047
106Aplasia of the phalanges of the hand (HP:0009802)1.93456047
107Epidermoid cyst (HP:0200040)1.93452700
108Hyperkalemia (HP:0002153)1.92779784
109Cupped ear (HP:0000378)1.91499204
110Clitoromegaly (HP:0000057)1.89879216
111Facial shape deformation (HP:0011334)1.88986796
112Potter facies (HP:0002009)1.88986796
113Rectal prolapse (HP:0002035)1.88968479
114Hypokalemia (HP:0002900)1.88560613
115Pancreatic islet-cell hyperplasia (HP:0004510)1.88228244
116Abnormality of the pupil (HP:0000615)1.87057747
117Hypoglycemic seizures (HP:0002173)1.86611176
118Abnormality of urine glucose concentration (HP:0011016)1.85043081
119Glycosuria (HP:0003076)1.85043081
120Vascular calcification (HP:0004934)1.84363863
121Mitral stenosis (HP:0001718)1.83556057
122Hydroxyprolinuria (HP:0003080)1.82821342
123Abnormality of proline metabolism (HP:0010907)1.82821342
124Palmoplantar hyperkeratosis (HP:0000972)1.80168830
125Long clavicles (HP:0000890)1.79889021
126Hypogonadotrophic hypogonadism (HP:0000044)1.79477371
127Morphological abnormality of the middle ear (HP:0008609)1.77970588
128Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77873974
129Asymmetric growth (HP:0100555)1.76837467
130Ileus (HP:0002595)1.76763307
131Onion bulb formation (HP:0003383)1.76227571
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75143112
133Ankle contracture (HP:0006466)1.74695447
134Osteoporosis (HP:0000939)1.74486544
135Cervical subluxation (HP:0003308)1.73348572
136Acanthosis nigricans (HP:0000956)1.72049338
137Skin nodule (HP:0200036)1.71805609
138Hypolipoproteinemia (HP:0010981)1.71532998
139Long foot (HP:0001833)1.71238311
140Absent hair (HP:0002298)1.70808420
141Short tibia (HP:0005736)1.68938415
142Bifid scrotum (HP:0000048)1.66203236
143Neonatal hypoglycemia (HP:0001998)1.64063246
144Episodic fever (HP:0001954)1.63845691
145Broad metatarsal (HP:0001783)1.63072456
146Protrusio acetabuli (HP:0003179)1.60133524
147Buphthalmos (HP:0000557)1.56586072
148Xanthomatosis (HP:0000991)1.54863211
149Lower limb asymmetry (HP:0100559)1.53725258
150Cavernous hemangioma (HP:0001048)1.52828893
151Arachnodactyly (HP:0001166)1.50478041
152Cerebral palsy (HP:0100021)1.47926775
153Female pseudohermaphroditism (HP:0010458)1.45907850
154Decreased testicular size (HP:0008734)1.45633245
155Multifactorial inheritance (HP:0001426)1.44380595
156Increased number of teeth (HP:0011069)1.44352511
157Short hallux (HP:0010109)1.43288642
158Cerebral aneurysm (HP:0004944)1.42237622
159Oligomenorrhea (HP:0000876)1.41050902
160Premature rupture of membranes (HP:0001788)1.40424346
161Aplasia/Hypoplasia of the hallux (HP:0008362)1.33000228
162Complement deficiency (HP:0004431)1.26584506
163Short middle phalanx of the 5th finger (HP:0004220)1.26522446
164Selective tooth agenesis (HP:0001592)1.26339900
165Male infertility (HP:0003251)1.24811351
166Abnormality of the alveolar ridges (HP:0006477)1.22850650
167Primary amenorrhea (HP:0000786)1.22813541
168Acne (HP:0001061)1.20215621
169Abnormal autonomic nervous system physiology (HP:0012332)1.20214815
170Hyponatremia (HP:0002902)1.19790330
171Hypergonadotropic hypogonadism (HP:0000815)1.18751325
172Breech presentation (HP:0001623)1.17226915
173Hypospadias (HP:0000047)1.16244468
174Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.14904076
175Atrioventricular block (HP:0001678)1.14542974
176Atrioventricular canal defect (HP:0006695)1.14031184
177Nephritis (HP:0000123)1.13238832
178Abnormality of glutamine family amino acid metabolism (HP:0010902)1.11950203
179Aortic aneurysm (HP:0004942)1.11889494
180Abnormality of the clitoris (HP:0000056)1.10886761
181Coronal craniosynostosis (HP:0004440)1.10083284
182Hypotension (HP:0002615)1.09932601
183Shallow orbits (HP:0000586)1.07690699
184Shawl scrotum (HP:0000049)1.07365030
185Back pain (HP:0003418)1.06709097
186Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.06207678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.05461504
2PIK3CG5.34955231
3AKT35.09665887
4CDK73.15521523
5ERN13.06033038
6PKN22.71749640
7MST42.68997505
8LRRK22.33596605
9PTK62.13052585
10PINK12.09018236
11FER2.06472458
12PAK11.90113651
13MAP3K121.89146214
14KSR21.87011911
15TGFBR21.74347671
16PDGFRA1.62485124
17TAOK31.61552209
18BLK1.61367551
19PAK31.57358338
20FGFR21.57151343
21ACVR1B1.48807407
22SIK11.42215613
23CAMK1G1.40985569
24PRKAA21.39764227
25STK381.38715159
26ILK1.33327616
27EPHB21.31364490
28EPHA21.28291714
29MYLK1.28083855
30TTN1.27439966
31RIPK11.25395262
32DAPK31.24869340
33PDK21.23726220
34FGFR41.15072166
35MAPK121.12449802
36DAPK11.11949901
37PIK3CA1.11588923
38EEF2K1.10038089
39LATS11.08312864
40MAP3K21.05451291
41BCKDK1.04850274
42JAK21.03776284
43FGFR11.01333797
44STK38L1.00102141
45CSNK1A1L0.99546581
46INSR0.98625917
47MAPK30.97313612
48CSNK1G10.97201385
49WNK40.96405195
50PRKG20.95929906
51LMTK20.94936291
52RIPK40.93645862
53TESK10.92709969
54SGK2230.88270107
55SGK4940.88270107
56PKN10.88208495
57PRKAA10.88056065
58PAK40.86742693
59UHMK10.86557445
60ICK0.85866217
61EGFR0.84781347
62STK390.83337261
63TAOK10.83243193
64RET0.82628061
65AKT20.82625390
66CAMK1D0.81553880
67CDK60.79030856
68NEK90.77491449
69KDR0.75645975
70NTRK10.75075105
71TNK20.73271892
72MAP2K10.73146447
73LATS20.72234024
74TIE10.71642568
75SCYL20.71406358
76ERBB40.70733769
77PTK2B0.69799208
78NLK0.68374118
79MAPK40.67498995
80MET0.65405021
81PNCK0.64541212
82LIMK10.64244959
83PAK20.63891885
84STK30.62869647
85PRKCH0.62268501
86OBSCN0.62156872
87RPS6KA20.61846432
88PDPK10.61655769
89OXSR10.61486567
90PRKD10.60554397
91MTOR0.60060759
92SGK30.59598697
93MAPK70.58407211
94TRPM70.58383875
95RPS6KA30.57894555
96TGFBR10.57402813
97KSR10.56561162
98PTK20.55803276
99SGK20.55243608
100NEK10.54984094
101MAP3K30.54294745
102CAMK10.53340975
103EIF2AK30.52926100
104DYRK1B0.52678843
105CAMKK10.50648526
106FGFR30.50179692
107GSK3A0.48485011
108DMPK0.47684072
109YES10.47637778
110DDR20.47193996
111PRKCZ0.45760724
112MAPK10.45309894
113WNK10.45038202
114IGF1R0.44871113
115MST1R0.43756392
116CASK0.43161341
117TYRO30.43087950
118MELK0.42274291
119PRKCG0.41356560
120CDK40.41174393
121JAK30.40701710
122ABL20.39633737
123SRC0.39275288
124PDGFRB0.39060960
125MAP3K90.38787077
126PRKACG0.38437570
127PDK10.38434949
128FRK0.37534325
129CSNK1G30.37463734
130EPHA30.37452450
131NTRK30.36007669
132MARK20.35694579
133CSNK1G20.34967740
134ROCK10.34789794
135CDC42BPA0.34675534
136DAPK20.34544040
137PRKCQ0.34050328
138TYK20.33758008
139ALK0.33281965
140MAP3K70.32636629
141INSRR0.32462639
142NME10.32207581
143PRKCA0.32121015
144BMPR1B0.32001967
145PRKCE0.31568418
146RPS6KL10.31019505
147RPS6KC10.31019505
148MAP3K10.30990415
149ERBB30.30807115
150BCR0.30175968
151RPS6KA60.28867740
152ERBB20.26644589
153PRKD20.26592748
154STK100.26123701

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ovarian steroidogenesis_Homo sapiens_hsa049137.93918848
2* Steroid hormone biosynthesis_Homo sapiens_hsa001407.63763228
3* Aldosterone synthesis and secretion_Homo sapiens_hsa049254.76778582
4Fatty acid metabolism_Homo sapiens_hsa012122.84891522
5Fatty acid biosynthesis_Homo sapiens_hsa000612.79750660
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.75451248
7Fatty acid degradation_Homo sapiens_hsa000712.66724544
8Steroid biosynthesis_Homo sapiens_hsa001002.51843493
9Renin-angiotensin system_Homo sapiens_hsa046142.35471911
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32876852
11Mineral absorption_Homo sapiens_hsa049782.30005878
12Folate biosynthesis_Homo sapiens_hsa007902.25668891
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20345516
14Jak-STAT signaling pathway_Homo sapiens_hsa046302.14949023
15Sphingolipid metabolism_Homo sapiens_hsa006002.12753546
16PPAR signaling pathway_Homo sapiens_hsa033201.80346280
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80158775
18Tyrosine metabolism_Homo sapiens_hsa003501.73013929
19N-Glycan biosynthesis_Homo sapiens_hsa005101.64338828
20Pyruvate metabolism_Homo sapiens_hsa006201.55205157
21Vitamin digestion and absorption_Homo sapiens_hsa049771.49923224
22Fat digestion and absorption_Homo sapiens_hsa049751.47282750
23Propanoate metabolism_Homo sapiens_hsa006401.31344924
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27211082
25Other glycan degradation_Homo sapiens_hsa005111.27137041
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18160475
27Carbon metabolism_Homo sapiens_hsa012001.17640214
28Fatty acid elongation_Homo sapiens_hsa000621.17470003
29Bile secretion_Homo sapiens_hsa049761.09561963
30Protein digestion and absorption_Homo sapiens_hsa049741.04866313
31Sulfur relay system_Homo sapiens_hsa041221.03369919
32Nitrogen metabolism_Homo sapiens_hsa009100.95103346
33Starch and sucrose metabolism_Homo sapiens_hsa005000.92016596
34Peroxisome_Homo sapiens_hsa041460.87936288
35Retinol metabolism_Homo sapiens_hsa008300.86121895
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85572107
37Inositol phosphate metabolism_Homo sapiens_hsa005620.83861633
38Prolactin signaling pathway_Homo sapiens_hsa049170.82972530
39Butanoate metabolism_Homo sapiens_hsa006500.82939595
40TGF-beta signaling pathway_Homo sapiens_hsa043500.82254259
41Galactose metabolism_Homo sapiens_hsa000520.76874189
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.75780924
43Lysine degradation_Homo sapiens_hsa003100.72351111
44Tryptophan metabolism_Homo sapiens_hsa003800.72137228
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65354105
46Tight junction_Homo sapiens_hsa045300.63951479
47Glutathione metabolism_Homo sapiens_hsa004800.63456800
48Estrogen signaling pathway_Homo sapiens_hsa049150.60105056
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.59730579
50Renin secretion_Homo sapiens_hsa049240.58735888
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56776403
52beta-Alanine metabolism_Homo sapiens_hsa004100.56729193
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55954211
54Complement and coagulation cascades_Homo sapiens_hsa046100.55917496
55Salivary secretion_Homo sapiens_hsa049700.54715377
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.54698235
57ECM-receptor interaction_Homo sapiens_hsa045120.53418200
58cAMP signaling pathway_Homo sapiens_hsa040240.51395806
59Arginine and proline metabolism_Homo sapiens_hsa003300.51118887
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51100425
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50902938
62Biosynthesis of amino acids_Homo sapiens_hsa012300.48115517
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47672961
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47429433
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46984390
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46566683
67Insulin resistance_Homo sapiens_hsa049310.43252397
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.42778451
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.41986476
70Focal adhesion_Homo sapiens_hsa045100.41953509
71Adherens junction_Homo sapiens_hsa045200.41306590
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.40215524
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40036662
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.39232308
75Glycerolipid metabolism_Homo sapiens_hsa005610.38675625
76Prostate cancer_Homo sapiens_hsa052150.38040301
77Chemical carcinogenesis_Homo sapiens_hsa052040.35922731
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35072478
79Axon guidance_Homo sapiens_hsa043600.35071005
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34742014
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34675836
82Proteoglycans in cancer_Homo sapiens_hsa052050.34484769
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32488407
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32319883
85Staphylococcus aureus infection_Homo sapiens_hsa051500.32307582
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32303625
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.32049133
88Vibrio cholerae infection_Homo sapiens_hsa051100.31103974
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30917515
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30387759
91Hedgehog signaling pathway_Homo sapiens_hsa043400.30286342
92Thyroid hormone synthesis_Homo sapiens_hsa049180.29331058
93Sulfur metabolism_Homo sapiens_hsa009200.29278511
94ABC transporters_Homo sapiens_hsa020100.29178620
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27938593
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27677872
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.27104797
98Vitamin B6 metabolism_Homo sapiens_hsa007500.26624124
99Ras signaling pathway_Homo sapiens_hsa040140.26577747
100Small cell lung cancer_Homo sapiens_hsa052220.26232878
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23864991
102Glucagon signaling pathway_Homo sapiens_hsa049220.23737952
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23260130
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22768217
105Linoleic acid metabolism_Homo sapiens_hsa005910.21633626
106Oxytocin signaling pathway_Homo sapiens_hsa049210.21514388
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21268538
108Calcium signaling pathway_Homo sapiens_hsa040200.21244163
109Histidine metabolism_Homo sapiens_hsa003400.20827252
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20467918
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20265231
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20194398
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19457289
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.19173866
115Gastric acid secretion_Homo sapiens_hsa049710.18371056
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18223219
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18122619
118Wnt signaling pathway_Homo sapiens_hsa043100.17544266
119Amoebiasis_Homo sapiens_hsa051460.16145370
120Dopaminergic synapse_Homo sapiens_hsa047280.16054858
121Arginine biosynthesis_Homo sapiens_hsa002200.15738811
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14611888
123Dilated cardiomyopathy_Homo sapiens_hsa054140.14552860
124Prion diseases_Homo sapiens_hsa050200.14158072
125Lysosome_Homo sapiens_hsa041420.13743958
126Phagosome_Homo sapiens_hsa041450.12962611
127Cocaine addiction_Homo sapiens_hsa050300.12160389
128Amphetamine addiction_Homo sapiens_hsa050310.11640726
129Long-term potentiation_Homo sapiens_hsa047200.10972569
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10753311
131AMPK signaling pathway_Homo sapiens_hsa041520.10684697
132Circadian entrainment_Homo sapiens_hsa047130.10646955
133Phenylalanine metabolism_Homo sapiens_hsa003600.10443066
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09669348
135Melanogenesis_Homo sapiens_hsa049160.09607129
136* Metabolic pathways_Homo sapiens_hsa011000.09431474
137Renal cell carcinoma_Homo sapiens_hsa052110.07901927
138Gap junction_Homo sapiens_hsa045400.07569577
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.06234102
140Insulin signaling pathway_Homo sapiens_hsa049100.05814785

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