HSD3B7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.35476508
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35476508
3L-phenylalanine metabolic process (GO:0006558)7.03082966
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.03082966
5aromatic amino acid family catabolic process (GO:0009074)6.61193977
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.13423283
7tryptophan catabolic process (GO:0006569)6.01537509
8indole-containing compound catabolic process (GO:0042436)6.01537509
9indolalkylamine catabolic process (GO:0046218)6.01537509
10kynurenine metabolic process (GO:0070189)5.85615741
11* bile acid biosynthetic process (GO:0006699)5.71847989
12glyoxylate metabolic process (GO:0046487)5.66422429
13tryptophan metabolic process (GO:0006568)5.66407882
14alpha-linolenic acid metabolic process (GO:0036109)5.56315608
15urea cycle (GO:0000050)5.45056040
16urea metabolic process (GO:0019627)5.45056040
17cysteine metabolic process (GO:0006534)5.43214101
18negative regulation of fibrinolysis (GO:0051918)5.38156123
19high-density lipoprotein particle remodeling (GO:0034375)5.37365733
20complement activation, alternative pathway (GO:0006957)5.36003481
21sulfur amino acid catabolic process (GO:0000098)5.34745993
22peptidyl-glutamic acid carboxylation (GO:0017187)5.29262729
23protein carboxylation (GO:0018214)5.29262729
24regulation of protein activation cascade (GO:2000257)5.28964598
25regulation of fibrinolysis (GO:0051917)5.22280890
26nitrogen cycle metabolic process (GO:0071941)5.03500223
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98694836
28regulation of complement activation (GO:0030449)4.95744384
29serine family amino acid catabolic process (GO:0009071)4.90717756
30* bile acid metabolic process (GO:0008206)4.85137932
31regulation of cholesterol esterification (GO:0010872)4.78075585
32aromatic amino acid family metabolic process (GO:0009072)4.77560270
33oligosaccharide catabolic process (GO:0009313)4.77327631
34regulation of triglyceride catabolic process (GO:0010896)4.76571271
35reverse cholesterol transport (GO:0043691)4.70929024
36plasma lipoprotein particle remodeling (GO:0034369)4.64598929
37protein-lipid complex remodeling (GO:0034368)4.64598929
38macromolecular complex remodeling (GO:0034367)4.64598929
39homocysteine metabolic process (GO:0050667)4.58827260
40amino-acid betaine metabolic process (GO:0006577)4.58591869
41glycosphingolipid catabolic process (GO:0046479)4.57255292
42tyrosine metabolic process (GO:0006570)4.55660461
43phospholipid efflux (GO:0033700)4.51524458
44triglyceride homeostasis (GO:0070328)4.51096936
45acylglycerol homeostasis (GO:0055090)4.51096936
46alpha-amino acid catabolic process (GO:1901606)4.50544389
47lysine metabolic process (GO:0006553)4.45684929
48lysine catabolic process (GO:0006554)4.45684929
49glycine metabolic process (GO:0006544)4.36072442
50bile acid and bile salt transport (GO:0015721)4.35482062
51imidazole-containing compound metabolic process (GO:0052803)4.35133954
52fat-soluble vitamin biosynthetic process (GO:0042362)4.34805398
53negative regulation of sterol transport (GO:0032372)4.34750958
54negative regulation of cholesterol transport (GO:0032375)4.34750958
55coenzyme catabolic process (GO:0009109)4.32130670
56plasma lipoprotein particle clearance (GO:0034381)4.30547462
57indolalkylamine metabolic process (GO:0006586)4.24285217
58cellular ketone body metabolic process (GO:0046950)4.20358793
59cellular biogenic amine catabolic process (GO:0042402)4.19718413
60amine catabolic process (GO:0009310)4.19718413
61ethanol oxidation (GO:0006069)4.19652516
62glycolipid catabolic process (GO:0019377)4.15989460
63cellular amino acid catabolic process (GO:0009063)4.14966815
64serine family amino acid metabolic process (GO:0009069)4.11618429
65low-density lipoprotein particle remodeling (GO:0034374)4.06555554
66cholesterol efflux (GO:0033344)4.05881992
67blood coagulation, intrinsic pathway (GO:0007597)4.03014414
68glutamate metabolic process (GO:0006536)4.02727135
69serine family amino acid biosynthetic process (GO:0009070)4.00391672
70benzene-containing compound metabolic process (GO:0042537)3.97056204
71cellular modified amino acid catabolic process (GO:0042219)3.96620172
72cellular glucuronidation (GO:0052695)3.95217715
73fibrinolysis (GO:0042730)3.93056256
74aldehyde catabolic process (GO:0046185)3.91704984
75plasma lipoprotein particle assembly (GO:0034377)3.90024940
76arginine metabolic process (GO:0006525)3.87578762
77ceramide catabolic process (GO:0046514)3.81742725
78cofactor catabolic process (GO:0051187)3.77371638
79protein activation cascade (GO:0072376)3.77340278
80positive regulation of triglyceride lipase activity (GO:0061365)3.75508301
81positive regulation of lipoprotein lipase activity (GO:0051006)3.75508301
82complement activation, classical pathway (GO:0006958)3.74272842
83complement activation (GO:0006956)3.71795282
84organic acid catabolic process (GO:0016054)3.69206672
85carboxylic acid catabolic process (GO:0046395)3.69206672
86dicarboxylic acid biosynthetic process (GO:0043650)3.68301517
87cholesterol homeostasis (GO:0042632)3.66013061
88phospholipid homeostasis (GO:0055091)3.65266522
89opsonization (GO:0008228)3.65098310
90negative regulation of lipase activity (GO:0060192)3.63792167
91epoxygenase P450 pathway (GO:0019373)3.63276017
92ketone body metabolic process (GO:1902224)3.63009973
93cytolysis (GO:0019835)3.61723963
94drug catabolic process (GO:0042737)3.59941130
95NAD biosynthetic process (GO:0009435)3.59514345
96sterol homeostasis (GO:0055092)3.58938468
97short-chain fatty acid metabolic process (GO:0046459)3.58588147
98very-low-density lipoprotein particle assembly (GO:0034379)3.58254384
99pyridine nucleotide biosynthetic process (GO:0019363)3.57487077
100nicotinamide nucleotide biosynthetic process (GO:0019359)3.57487077
101acetyl-CoA metabolic process (GO:0006084)3.56085648
102positive regulation of lipid catabolic process (GO:0050996)3.55971779
103plasma lipoprotein particle organization (GO:0071827)3.55561206
104regulation of cholesterol homeostasis (GO:2000188)3.55180059
105exogenous drug catabolic process (GO:0042738)3.53805776
106regulation of cholesterol storage (GO:0010885)3.53407693
107barbed-end actin filament capping (GO:0051016)3.49878305
108amino sugar catabolic process (GO:0046348)3.48860013
109uronic acid metabolic process (GO:0006063)3.48742900
110glucuronate metabolic process (GO:0019585)3.48742900
111regulation of plasminogen activation (GO:0010755)3.46531068
112omega-hydroxylase P450 pathway (GO:0097267)3.42118138
113positive regulation of fatty acid biosynthetic process (GO:0045723)3.39872928
114adhesion of symbiont to host (GO:0044406)3.39827857
115adhesion of symbiont to host cell (GO:0044650)3.29769698
116virion attachment to host cell (GO:0019062)3.29769698
117negative regulation of blood coagulation (GO:0030195)3.25362870
118negative regulation of hemostasis (GO:1900047)3.25362870
119regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22325126
120membrane lipid catabolic process (GO:0046466)3.20765663
121positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.20225243
122sphingolipid catabolic process (GO:0030149)3.20082590
123negative regulation of coagulation (GO:0050819)3.19960357
124positive regulation of extracellular matrix organization (GO:1903055)3.05669258
125response to thyroid hormone (GO:0097066)3.04189121
126low-density lipoprotein particle clearance (GO:0034383)3.02848659
127acute-phase response (GO:0006953)3.00757032
128keratan sulfate catabolic process (GO:0042340)2.91336897
129protein-lipid complex assembly (GO:0065005)2.89890356
130protein-lipid complex subunit organization (GO:0071825)2.86373988
131apoptotic cell clearance (GO:0043277)2.82510230
132cellular response to thyroid hormone stimulus (GO:0097067)2.79892408
133lipoprotein metabolic process (GO:0042157)2.79805413
134negative regulation of wound healing (GO:0061045)2.79321433
135regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76008283
136fructose metabolic process (GO:0006000)2.73642211
137negative regulation of fatty acid biosynthetic process (GO:0045717)2.71744433
138positive regulation of triglyceride metabolic process (GO:0090208)2.69243124
139negative regulation of lipid transport (GO:0032369)2.68155867
140hyaluronan catabolic process (GO:0030214)2.67558326
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67244133
142eosinophil chemotaxis (GO:0048245)2.66548021
143mannose metabolic process (GO:0006013)2.66253349
144pinocytosis (GO:0006907)2.66146197
145regulation of mononuclear cell migration (GO:0071675)2.65117938
146negative regulation of nitric oxide biosynthetic process (GO:0045019)2.63698798
147amyloid precursor protein catabolic process (GO:0042987)2.63023026
148positive regulation of cholesterol efflux (GO:0010875)2.60689396
149negative regulation of protein activation cascade (GO:2000258)2.60348304
150negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57246661
151regulation of apoptotic cell clearance (GO:2000425)2.56283476
152regulation of cholesterol transport (GO:0032374)2.55894959
153regulation of sterol transport (GO:0032371)2.55894959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.10046348
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.97317132
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.91776282
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.18333904
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.19966130
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.08538753
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.02320296
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06448955
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63758758
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74187580
11GATA1_22025678_ChIP-Seq_K562_Human2.24253351
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16738611
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.05505904
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04853819
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.01444441
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6177618
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.97539749
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.93278207
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93170274
20RACK7_27058665_Chip-Seq_MCF-7_Human1.88290579
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.82900439
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.82339996
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73173027
24CLOCK_20551151_ChIP-Seq_293T_Human1.55590340
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51649466
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45468172
27* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45050207
28VDR_21846776_ChIP-Seq_THP-1_Human1.43447145
29HTT_18923047_ChIP-ChIP_STHdh_Human1.43412797
30* BCL6_27268052_Chip-Seq_Bcells_Human1.42907007
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.38518845
32* P68_20966046_ChIP-Seq_HELA_Human1.37305218
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.37239743
34* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35156804
35* ELF1_20517297_ChIP-Seq_JURKAT_Human1.33797698
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31109269
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29167354
38ATF3_27146783_Chip-Seq_COLON_Human1.29060785
39HNF4A_19822575_ChIP-Seq_HepG2_Human1.28216716
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26190019
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24019079
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23350368
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21924676
44JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21918775
45JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17288663
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15472432
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15301339
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15201799
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15069136
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14272478
51VDR_24763502_ChIP-Seq_THP-1_Human1.13927524
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13443178
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12394230
54SMC4_20622854_ChIP-Seq_HELA_Human1.10242281
55* E2F1_20622854_ChIP-Seq_HELA_Human1.09907744
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09611834
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08580957
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07422699
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06836343
60TFEB_21752829_ChIP-Seq_HELA_Human1.06426501
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05653602
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.05514539
63SOX2_20726797_ChIP-Seq_SW620_Human1.05229072
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04410650
65* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03030824
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02897188
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02714547
68TP53_22127205_ChIP-Seq_IMR90_Human1.01765487
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01004923
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99913455
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99595184
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99477097
73PHF8_20622854_ChIP-Seq_HELA_Human0.98552137
74KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98450341
75DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97982056
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97016900
77NCOR1_26117541_ChIP-Seq_K562_Human0.95320011
78* CTCF_20526341_ChIP-Seq_ESCs_Human0.95247830
79JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94806125
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94160886
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93318464
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92897433
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92897433
84RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92675762
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89438982
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88823658
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87706737
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87269819
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84605365
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84293501
91GATA4_25053715_ChIP-Seq_YYC3_Human0.84213789
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84180154
93SCL_19346495_ChIP-Seq_HPC-7_Human0.83546792
94ZNF263_19887448_ChIP-Seq_K562_Human0.82864272
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82053067
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79092682
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78783813
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74760407
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.73677239
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72027168
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70244883
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.69828504
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67457818
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.67086747
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.65996763
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.65070374
107* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65014494
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.62357513
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.61382812
110AR_20517297_ChIP-Seq_VCAP_Human0.60805888
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60565913
112* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60556425
113CEBPB_22108803_ChIP-Seq_LS180_Human0.60340678
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.59922177
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.59872355
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59795302
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.59497626
118* LXR_22292898_ChIP-Seq_THP-1_Human0.59065466
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58958099
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.58913069
121GATA1_19941826_ChIP-Seq_K562_Human0.57968301
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.55676103
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.54871416
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54307523
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.52761169
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52301155
127GATA2_19941826_ChIP-Seq_K562_Human0.51499845
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.51333706
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.51235794
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50681595
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50282570
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50282570
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50226549
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.49426714
135P53_21459846_ChIP-Seq_SAOS-2_Human0.49267469
136ESET_19884257_ChIP-Seq_ESCs_Mouse0.48604515
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.48603880
138CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.48436347
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.48408435
140EGR1_19032775_ChIP-ChIP_M12_Human0.48213085
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47103614
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.46622328
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.45856438
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45289352
145TAF2_19829295_ChIP-Seq_ESCs_Human0.45000375
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.44786518
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.44457788
148* MYC_19915707_ChIP-ChIP_AK7_Human0.44153113
149STAT1_17558387_ChIP-Seq_HELA_Human0.43436724
150* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42880769
151ERG_20517297_ChIP-Seq_VCAP_Human0.42843314
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.41683981
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.41673452
154* BCOR_27268052_Chip-Seq_Bcells_Human0.41403362
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.41178559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.93807184
2MP0005360_urolithiasis7.19533422
3MP0005085_abnormal_gallbladder_physiolo6.15439041
4* MP0005365_abnormal_bile_salt5.80288536
5MP0008875_abnormal_xenobiotic_pharmacok4.89025289
6MP0003806_abnormal_nucleotide_metabolis4.17801221
7MP0003252_abnormal_bile_duct3.75240551
8MP0010329_abnormal_lipoprotein_level3.54133498
9MP0009840_abnormal_foam_cell3.32726234
10MP0005083_abnormal_biliary_tract2.98823929
11MP0003172_abnormal_lysosome_physiology2.70714396
12MP0003195_calcinosis2.66665199
13MP0003191_abnormal_cellular_cholesterol2.62023331
14MP0005332_abnormal_amino_acid2.58465867
15MP0008438_abnormal_cutaneous_collagen2.51053890
16* MP0001666_abnormal_nutrient_absorption2.37180064
17* MP0000609_abnormal_liver_physiology2.15994296
18MP0005257_abnormal_intraocular_pressure2.05486429
19* MP0002118_abnormal_lipid_homeostasis2.05142285
20MP0002138_abnormal_hepatobiliary_system2.01110667
21MP0004019_abnormal_vitamin_homeostasis2.00036400
22MP0005319_abnormal_enzyme/_coenzyme1.86966343
23MP0003868_abnormal_feces_composition1.83323801
24MP0000343_altered_response_to1.78195380
25MP0001764_abnormal_homeostasis1.76365671
26MP0005584_abnormal_enzyme/coenzyme_acti1.60622414
27MP0009697_abnormal_copulation1.58256596
28MP0003186_abnormal_redox_activity1.48239618
29MP0003011_delayed_dark_adaptation1.44830712
30MP0003656_abnormal_erythrocyte_physiolo1.42579210
31MP0003950_abnormal_plasma_membrane1.41562293
32MP0002148_abnormal_hypersensitivity_rea1.40686274
33MP0002877_abnormal_melanocyte_morpholog1.37848057
34MP0005451_abnormal_body_composition1.36523558
35MP0010368_abnormal_lymphatic_system1.31623971
36MP0009643_abnormal_urine_homeostasis1.26594487
37MP0002998_abnormal_bone_remodeling1.25613241
38MP0000598_abnormal_liver_morphology1.24474947
39MP0002254_reproductive_system_inflammat1.22045432
40MP0001533_abnormal_skeleton_physiology1.21934281
41MP0005023_abnormal_wound_healing1.20625386
42MP0006054_spinal_hemorrhage1.18024059
43MP0005647_abnormal_sex_gland1.16868372
44MP0009764_decreased_sensitivity_to1.15001690
45MP0003279_aneurysm1.12569176
46MP0005164_abnormal_response_to1.11019255
47MP0009763_increased_sensitivity_to1.10233426
48MP0008469_abnormal_protein_level1.07345059
49MP0001958_emphysema1.07145761
50MP0003724_increased_susceptibility_to1.05387439
51MP0003705_abnormal_hypodermis_morpholog1.04732819
52MP0001542_abnormal_bone_strength1.04586672
53MP0000604_amyloidosis1.03983530
54MP0004272_abnormal_basement_membrane1.03403629
55MP0000858_altered_metastatic_potential1.02888164
56MP0005165_increased_susceptibility_to0.97329391
57MP0005636_abnormal_mineral_homeostasis0.96304714
58MP0005670_abnormal_white_adipose0.95752662
59MP0003453_abnormal_keratinocyte_physiol0.93868995
60MP0003303_peritoneal_inflammation0.92132555
61MP0003566_abnormal_cell_adhesion0.91420576
62MP0006036_abnormal_mitochondrial_physio0.91022573
63MP0005084_abnormal_gallbladder_morpholo0.90502798
64MP0002896_abnormal_bone_mineralization0.89547724
65* MP0009642_abnormal_blood_homeostasis0.89160946
66MP0004510_myositis0.87785645
67MP0001545_abnormal_hematopoietic_system0.87782975
68MP0005397_hematopoietic_system_phenotyp0.87782975
69MP0000371_diluted_coat_color0.87717495
70MP0005464_abnormal_platelet_physiology0.87467579
71MP0005220_abnormal_exocrine_pancreas0.84601378
72MP0005408_hypopigmentation0.83478069
73MP0004858_abnormal_nervous_system0.83399540
74MP0005376_homeostasis/metabolism_phenot0.83334318
75MP0005410_abnormal_fertilization0.79734365
76MP0004947_skin_inflammation0.79657770
77MP0009765_abnormal_xenobiotic_induced0.79631362
78MP0003879_abnormal_hair_cell0.78312197
79MP0002876_abnormal_thyroid_physiology0.76895194
80MP0002971_abnormal_brown_adipose0.76831078
81MP0003091_abnormal_cell_migration0.76209312
82MP0004130_abnormal_muscle_cell0.75428070
83MP0002078_abnormal_glucose_homeostasis0.75198902
84MP0003448_altered_tumor_morphology0.74727672
85MP0005595_abnormal_vascular_smooth0.74460212
86MP0003436_decreased_susceptibility_to0.74282277
87MP0004233_abnormal_muscle_weight0.73924288
88MP0005334_abnormal_fat_pad0.73770755
89MP0009333_abnormal_splenocyte_physiolog0.72456455
90MP0008260_abnormal_autophagy0.72084305
91MP0010234_abnormal_vibrissa_follicle0.71964135
92MP0009278_abnormal_bone_marrow0.71286667
93MP0005387_immune_system_phenotype0.70946957
94MP0001790_abnormal_immune_system0.70946957
95MP0002933_joint_inflammation0.70603781
96MP0001853_heart_inflammation0.68707515
97MP0005266_abnormal_metabolism0.68049873
98MP0005390_skeleton_phenotype0.66931251
99MP0003795_abnormal_bone_structure0.66099015
100MP0005535_abnormal_body_temperature0.64798632
101MP0002295_abnormal_pulmonary_circulatio0.64228128
102MP0005167_abnormal_blood-brain_barrier0.64137604
103MP0003300_gastrointestinal_ulcer0.63683972
104MP0005275_abnormal_skin_tensile0.62947056
105MP0001661_extended_life_span0.61064124
106MP0000639_abnormal_adrenal_gland0.58859469
107MP0003690_abnormal_glial_cell0.58802948
108MP0005058_abnormal_lysosome_morphology0.58492140
109MP0001756_abnormal_urination0.57549052
110MP0004782_abnormal_surfactant_physiolog0.57220926
111MP0003638_abnormal_response/metabolism_0.56138758
112MP0003075_altered_response_to0.55817771
113MP0005448_abnormal_energy_balance0.55749951
114MP0008873_increased_physiological_sensi0.51912717
115MP0002928_abnormal_bile_duct0.51266731
116MP0006035_abnormal_mitochondrial_morpho0.50865641
117MP0004381_abnormal_hair_follicle0.49249083
118MP0002136_abnormal_kidney_physiology0.48892435
119MP0009785_altered_susceptibility_to0.48422318
120MP0001845_abnormal_inflammatory_respons0.47609365
121MP0009379_abnormal_foot_pigmentation0.46848906
122MP0005666_abnormal_adipose_tissue0.45189206
123MP0005166_decreased_susceptibility_to0.45155900
124MP0000249_abnormal_blood_vessel0.44443712
125MP0005075_abnormal_melanosome_morpholog0.43937140
126MP0006082_CNS_inflammation0.43327450
127MP0003329_amyloid_beta_deposits0.43083166
128MP0004147_increased_porphyrin_level0.43063701
129MP0002132_abnormal_respiratory_system0.43026314
130MP0009115_abnormal_fat_cell0.42578167
131MP0003718_maternal_effect0.42463556
132MP0005395_other_phenotype0.42090464
133MP0005025_abnormal_response_to0.41394701
134MP0002419_abnormal_innate_immunity0.41308222
135MP0001835_abnormal_antigen_presentation0.39803733
136MP0002970_abnormal_white_adipose0.39479550
137MP0003953_abnormal_hormone_level0.39003712
138MP0008874_decreased_physiological_sensi0.38101097
139MP0000685_abnormal_immune_system0.37728159
140MP0009053_abnormal_anal_canal0.36241060
141MP0001243_abnormal_dermal_layer0.36017254
142MP0000230_abnormal_systemic_arterial0.34830285
143MP0002060_abnormal_skin_morphology0.34033510
144MP0002796_impaired_skin_barrier0.33299436
145MP0001881_abnormal_mammary_gland0.33204245
146MP0009384_cardiac_valve_regurgitation0.33178826
147MP0004883_abnormal_blood_vessel0.33130221

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.23534184
2Deep venous thrombosis (HP:0002625)7.03613486
3* Intrahepatic cholestasis (HP:0001406)6.79247863
4Abnormality of glycolipid metabolism (HP:0010969)6.56356044
5Abnormality of liposaccharide metabolism (HP:0010968)6.56356044
6Abnormality of glycosphingolipid metabolism (HP:0004343)6.56356044
7Prolonged partial thromboplastin time (HP:0003645)6.47042081
8Abnormality of monocarboxylic acid metabolism (HP:0010996)6.38694331
9Xanthomatosis (HP:0000991)6.12610260
10Hypobetalipoproteinemia (HP:0003563)6.03058551
11Hyperlipoproteinemia (HP:0010980)5.42030695
12Complement deficiency (HP:0004431)5.36612113
13Joint hemorrhage (HP:0005261)4.76603281
14Vacuolated lymphocytes (HP:0001922)4.64440228
15Hypolipoproteinemia (HP:0010981)4.53959469
16Hyperammonemia (HP:0001987)4.48731512
17Abnormality of the common coagulation pathway (HP:0010990)4.48520626
18Epidermoid cyst (HP:0200040)4.33417570
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.22623411
20Dysostosis multiplex (HP:0000943)4.22420978
21Hyperglycinemia (HP:0002154)4.18139441
22Abnormality of methionine metabolism (HP:0010901)4.11362938
23Ketosis (HP:0001946)4.11311016
24Abnormality of polysaccharide metabolism (HP:0011012)4.07515808
25Abnormality of glycosaminoglycan metabolism (HP:0004371)4.07515808
26Abnormality of mucopolysaccharide metabolism (HP:0011020)4.07515808
27Abnormality of sulfur amino acid metabolism (HP:0004339)4.04469224
28Hypoalphalipoproteinemia (HP:0003233)3.99673082
29Abnormality of complement system (HP:0005339)3.96084014
30Urinary glycosaminoglycan excretion (HP:0003541)3.94763050
31Mucopolysacchariduria (HP:0008155)3.94763050
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.94179141
33Hypoglycemic coma (HP:0001325)3.93699862
34Abnormality of the intrinsic pathway (HP:0010989)3.93457706
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91563392
36Hyperglycinuria (HP:0003108)3.81314246
37* Fat malabsorption (HP:0002630)3.75899858
38Abnormality of serine family amino acid metabolism (HP:0010894)3.75793976
39Abnormality of glycine metabolism (HP:0010895)3.75793976
40Hypercholesterolemia (HP:0003124)3.71398733
41Conjugated hyperbilirubinemia (HP:0002908)3.68544477
42Increased cerebral lipofuscin (HP:0011813)3.66665277
43Abnormality of pyrimidine metabolism (HP:0004353)3.61256538
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49762141
45Abnormality of fatty-acid metabolism (HP:0004359)3.45821775
46Vertebral compression fractures (HP:0002953)3.26218849
47* Hyperbilirubinemia (HP:0002904)3.20042890
48Increased neuronal autofluorescent lipopigment (HP:0002074)3.13830296
49Spontaneous abortion (HP:0005268)3.10984422
50Delayed CNS myelination (HP:0002188)3.03985859
51Myocardial infarction (HP:0001658)3.01962555
52Systemic lupus erythematosus (HP:0002725)2.96803622
53Abnormality of serum amino acid levels (HP:0003112)2.94633671
54Premature rupture of membranes (HP:0001788)2.94371324
55Abnormality of nucleobase metabolism (HP:0010932)2.93856235
56Axonal loss (HP:0003447)2.93231145
57Ketoacidosis (HP:0001993)2.91569641
58Loss of speech (HP:0002371)2.88241155
59Hepatocellular carcinoma (HP:0001402)2.83531440
60J-shaped sella turcica (HP:0002680)2.82988761
61Hypochromic microcytic anemia (HP:0004840)2.77680363
62Metabolic acidosis (HP:0001942)2.75214461
63Acanthocytosis (HP:0001927)2.74546970
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73170324
65Dicarboxylic aciduria (HP:0003215)2.73170324
66* Steatorrhea (HP:0002570)2.66077374
67Skin nodule (HP:0200036)2.64778159
68Purpura (HP:0000979)2.62946819
69Recurrent gram-negative bacterial infections (HP:0005420)2.61152577
70Abnormality of purine metabolism (HP:0004352)2.60156083
71Gingival bleeding (HP:0000225)2.54507117
72Lethargy (HP:0001254)2.54187237
73Prolonged neonatal jaundice (HP:0006579)2.53620069
74Joint stiffness (HP:0001387)2.50610620
75Hypoglycemic seizures (HP:0002173)2.47025885
76Spastic diplegia (HP:0001264)2.44913003
77Glomerulonephritis (HP:0000099)2.43047112
78Amyloidosis (HP:0011034)2.42780912
79Vascular calcification (HP:0004934)2.41078230
80Menorrhagia (HP:0000132)2.38676813
81Abnormal gallbladder morphology (HP:0012437)2.35790238
82Generalized aminoaciduria (HP:0002909)2.33451112
83Thin bony cortex (HP:0002753)2.33055061
84Nuclear cataract (HP:0100018)2.32992441
85Neurofibrillary tangles (HP:0002185)2.31514232
86Abnormality of macrophages (HP:0004311)2.31281010
87Cervical subluxation (HP:0003308)2.30387725
88Cholelithiasis (HP:0001081)2.29738086
89Mitral stenosis (HP:0001718)2.28771967
90Cerebral edema (HP:0002181)2.28749930
91Asymmetric septal hypertrophy (HP:0001670)2.27993937
92Protrusio acetabuli (HP:0003179)2.27683064
93Esophageal varix (HP:0002040)2.26660116
94Abnormal gallbladder physiology (HP:0012438)2.25249308
95Cholecystitis (HP:0001082)2.25249308
96Thrombophlebitis (HP:0004418)2.24941478
97Retinal atrophy (HP:0001105)2.24872103
98Pancreatitis (HP:0001733)2.23412988
99Metaphyseal irregularity (HP:0003025)2.23300480
100Brushfield spots (HP:0001088)2.22265915
101Gout (HP:0001997)2.22158274
102Irritability (HP:0000737)2.20503173
103Protuberant abdomen (HP:0001538)2.19460715
104Late onset (HP:0003584)2.15950643
105Abnormality of the Achilles tendon (HP:0005109)2.15652380
106Malnutrition (HP:0004395)2.15134074
107Abnormality of iron homeostasis (HP:0011031)2.13318758
108Ovoid vertebral bodies (HP:0003300)2.13061688
109Cardiomegaly (HP:0001640)2.12457324
110Cardiovascular calcification (HP:0011915)2.12394438
111Opisthotonus (HP:0002179)2.11182287
112Poikilocytosis (HP:0004447)2.10552539
113Progressive neurologic deterioration (HP:0002344)2.08044689
114Mesangial abnormality (HP:0001966)2.07764906
115Sensorimotor neuropathy (HP:0007141)2.07004473
116Hemorrhage of the eye (HP:0011885)2.06806225
117Abnormality of transition element cation homeostasis (HP:0011030)2.05271461
118Vomiting (HP:0002013)2.05232043
119Distal lower limb muscle weakness (HP:0009053)1.95793233
120Renal cortical cysts (HP:0000803)1.92909884
121Enlarged kidneys (HP:0000105)1.92854272
122Abnormality of the gallbladder (HP:0005264)1.92476393
123Upper limb amyotrophy (HP:0009129)1.92476203
124Distal upper limb amyotrophy (HP:0007149)1.92476203
125Hypertriglyceridemia (HP:0002155)1.91265679
126Hyperinsulinemic hypoglycemia (HP:0000825)1.88741852
127* Elevated hepatic transaminases (HP:0002910)1.88014205
128Esophageal neoplasm (HP:0100751)1.87469816
129Neoplasm of head and neck (HP:0012288)1.87469816
130Achilles tendon contracture (HP:0001771)1.85695036
131Abnormal cartilage morphology (HP:0002763)1.85525846
132* Neonatal onset (HP:0003623)1.84536616
133Epistaxis (HP:0000421)1.84220568
134Bone pain (HP:0002653)1.84090444
135Hydroxyprolinuria (HP:0003080)1.82239519
136Abnormality of proline metabolism (HP:0010907)1.82239519
137Increased serum ferritin (HP:0003281)1.81491027
138Nonimmune hydrops fetalis (HP:0001790)1.79687938
139Abnormal enzyme/coenzyme activity (HP:0012379)1.77293950
140Hand muscle atrophy (HP:0009130)1.75486657
141Nephritis (HP:0000123)1.75325250
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.74659847
143Osteolytic defects of the hand bones (HP:0009699)1.74659847
144Increased mean platelet volume (HP:0011877)1.74052427
145Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74008070
146Polycythemia (HP:0001901)1.73857009
147Rickets (HP:0002748)1.73193222
148Pathologic fracture (HP:0002756)1.72177058
149Cerebral inclusion bodies (HP:0100314)1.71793032
150Hypophosphatemia (HP:0002148)1.70568293
151Multiple lipomas (HP:0001012)1.66806893
152Upper motor neuron abnormality (HP:0002127)1.65497365
153Abnormality of the periventricular white matter (HP:0002518)1.64605945
154Abdominal distention (HP:0003270)1.63348837
155Hepatosplenomegaly (HP:0001433)1.61996428
156Elevated alkaline phosphatase (HP:0003155)1.61769799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.61413153
2ERN14.41282101
3FGFR44.12814545
4SIK13.92143674
5TAOK33.60642098
6TESK13.12655407
7EPHA23.09416688
8INSRR2.58195142
9LIMK12.41875404
10TESK22.33436189
11FLT32.30131414
12ERBB42.27281647
13TYK22.24025170
14KDR2.15932226
15DDR22.13574437
16TIE12.12304273
17MST1R1.90932749
18MAPK111.90094847
19PDK21.89386456
20PIK3CG1.81895478
21TBK11.81157193
22PKN21.74235783
23MAP2K31.68672651
24TGFBR21.66757859
25ARAF1.62294587
26MAP2K41.55463588
27NEK91.53774570
28PAK41.52134065
29LMTK21.48777816
30ABL21.45166457
31TRIB31.44662414
32KIT1.38338462
33JAK21.34214208
34ICK1.27432977
35PTK61.24810586
36MAPK151.22967248
37PRKAA21.14859754
38MAP3K141.13866951
39JAK11.13768188
40IKBKE1.13123193
41GRK71.11913477
42IRAK31.11218250
43MAPK41.07529829
44CSF1R1.06983666
45MUSK1.02587624
46PDGFRA1.01812199
47FRK1.00481444
48CAMK1D1.00242750
49MAP4K10.99963894
50MAP3K70.99520356
51MOS0.98923298
52MAP3K30.96871390
53TGFBR10.93164705
54PINK10.92007429
55CDC42BPA0.91548383
56ADRBK20.91472320
57STK160.85945690
58ERBB20.84973810
59EPHB10.84817271
60EPHB20.83178351
61CDK60.82915018
62DAPK20.82595621
63JAK30.79695674
64LATS10.78503128
65MAP3K110.78340825
66GRK60.76917104
67ACVR1B0.75912235
68FGFR20.75192844
69MAPK120.74210179
70MAP2K60.73668557
71BMX0.73598786
72CAMKK20.71385839
73NME20.71088293
74TEC0.70407047
75EPHA30.69997396
76BTK0.69376372
77FER0.67567394
78DYRK1B0.67247968
79RPS6KA20.67096948
80MAP3K100.64001227
81MAP3K60.63888126
82MAP3K120.62902010
83CSK0.61871712
84MAPKAPK30.61436507
85MAPKAPK20.59945397
86TRPM70.57905775
87MET0.57277175
88PRKACG0.56883883
89RIPK10.56580117
90IKBKB0.55531839
91MAP3K20.54901042
92ZAP700.54253711
93GRK10.54159072
94PIM20.53702401
95PRKCZ0.51235365
96FGFR30.50957063
97PRKD20.50621756
98TTN0.50512442
99MYLK0.50334519
100MAP3K130.48366449
101PRKAA10.48037093
102GSK3A0.47864772
103ILK0.46897797
104SMG10.46219188
105IGF1R0.45929830
106PDK10.45840605
107MATK0.45559770
108CDK40.43770309
109STK380.42957144
110VRK20.42899892
111HIPK20.42735672
112CAMK2G0.41893431
113PRKCI0.41819608
114PRPF4B0.41183949
115DAPK10.40748994
116EIF2AK10.40417289
117PAK20.38917277
118MTOR0.38560411
119PAK10.37590631
120MAP3K10.35279644
121MAP3K80.34523194
122MAP2K20.34294790
123BLK0.33975550
124MAPK70.33199876
125LYN0.32999808
126PTK20.31542608
127CSNK1G10.31225674
128IRAK10.31056048
129CAMK2D0.30416984
130PRKCQ0.29717675
131NLK0.29680278
132MAP3K50.29635235
133DAPK30.29400269
134IRAK20.29088778
135PRKG20.29054085
136ABL10.29041785
137EGFR0.28782982
138MAPK30.28587200
139IRAK40.28348021
140SRC0.28038009
141PDPK10.27735740
142RPS6KL10.27625547
143RPS6KC10.27625547
144LRRK20.27386093
145MAP2K10.27041042
146PIM10.26646170
147TAOK20.26535119
148CHUK0.26093935

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.43790316
2Nitrogen metabolism_Homo sapiens_hsa009103.51753833
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30551666
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07154419
5Arginine biosynthesis_Homo sapiens_hsa002202.92471524
6Complement and coagulation cascades_Homo sapiens_hsa046102.83282714
7Tryptophan metabolism_Homo sapiens_hsa003802.68122133
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64439597
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58590653
10Fatty acid degradation_Homo sapiens_hsa000712.55871161
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52098059
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45480588
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28969081
14Peroxisome_Homo sapiens_hsa041462.15593355
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10248192
16Butanoate metabolism_Homo sapiens_hsa006502.01471300
17Propanoate metabolism_Homo sapiens_hsa006401.98210435
18Histidine metabolism_Homo sapiens_hsa003401.96461288
19Chemical carcinogenesis_Homo sapiens_hsa052041.92338947
20PPAR signaling pathway_Homo sapiens_hsa033201.90241142
21Caffeine metabolism_Homo sapiens_hsa002321.88542801
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88180637
23Staphylococcus aureus infection_Homo sapiens_hsa051501.86670984
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.85681960
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.82634366
26Fatty acid metabolism_Homo sapiens_hsa012121.82397794
27beta-Alanine metabolism_Homo sapiens_hsa004101.74467624
28Retinol metabolism_Homo sapiens_hsa008301.68756400
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67294395
30Selenocompound metabolism_Homo sapiens_hsa004501.67262407
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64167196
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60487507
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59757117
34Phenylalanine metabolism_Homo sapiens_hsa003601.47434340
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45351008
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45234280
37Bile secretion_Homo sapiens_hsa049761.43211246
38Folate biosynthesis_Homo sapiens_hsa007901.40902805
39Tyrosine metabolism_Homo sapiens_hsa003501.40429813
40Fatty acid elongation_Homo sapiens_hsa000621.37903242
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.34404513
42Pyruvate metabolism_Homo sapiens_hsa006201.32075103
43Sulfur metabolism_Homo sapiens_hsa009201.32033502
44Starch and sucrose metabolism_Homo sapiens_hsa005001.28605026
45ABC transporters_Homo sapiens_hsa020101.28412813
46Fat digestion and absorption_Homo sapiens_hsa049751.16981723
47Biosynthesis of amino acids_Homo sapiens_hsa012301.16233730
48Steroid biosynthesis_Homo sapiens_hsa001001.12951393
49Carbon metabolism_Homo sapiens_hsa012001.11774909
50Sphingolipid metabolism_Homo sapiens_hsa006001.10980572
51Sulfur relay system_Homo sapiens_hsa041221.10702434
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05155201
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.03483790
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.01152400
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99486615
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99026132
57Mineral absorption_Homo sapiens_hsa049780.97250008
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96037130
59Rheumatoid arthritis_Homo sapiens_hsa053230.93586971
60Arginine and proline metabolism_Homo sapiens_hsa003300.93086481
61Vitamin digestion and absorption_Homo sapiens_hsa049770.91090113
62Vitamin B6 metabolism_Homo sapiens_hsa007500.89397848
63One carbon pool by folate_Homo sapiens_hsa006700.84609894
64Phagosome_Homo sapiens_hsa041450.84237382
65Vibrio cholerae infection_Homo sapiens_hsa051100.78283778
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76895861
67Lysine degradation_Homo sapiens_hsa003100.75890487
68Glutathione metabolism_Homo sapiens_hsa004800.69609580
69Glycerolipid metabolism_Homo sapiens_hsa005610.68994515
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67338150
71Pentose phosphate pathway_Homo sapiens_hsa000300.67176514
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61946820
73N-Glycan biosynthesis_Homo sapiens_hsa005100.56861721
74Tuberculosis_Homo sapiens_hsa051520.53929914
75Fatty acid biosynthesis_Homo sapiens_hsa000610.53421600
76Osteoclast differentiation_Homo sapiens_hsa043800.53376947
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53345855
78Collecting duct acid secretion_Homo sapiens_hsa049660.52442691
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49402468
80* Metabolic pathways_Homo sapiens_hsa011000.48851960
81TNF signaling pathway_Homo sapiens_hsa046680.48519419
82Bladder cancer_Homo sapiens_hsa052190.42307387
83Galactose metabolism_Homo sapiens_hsa000520.39848498
84Leishmaniasis_Homo sapiens_hsa051400.35061153
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.31738808
86Salmonella infection_Homo sapiens_hsa051320.30949107
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30899488
88Prion diseases_Homo sapiens_hsa050200.30073185
89Amoebiasis_Homo sapiens_hsa051460.27405338
90Linoleic acid metabolism_Homo sapiens_hsa005910.26472068
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.26274998
92Fructose and mannose metabolism_Homo sapiens_hsa000510.26184067
93Asthma_Homo sapiens_hsa053100.25807392
94Antigen processing and presentation_Homo sapiens_hsa046120.25187676
95Toxoplasmosis_Homo sapiens_hsa051450.24889639
96Insulin resistance_Homo sapiens_hsa049310.23315105
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21825117
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.20506241
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.15596135
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07541032
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07419732
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.06084030
103Glucagon signaling pathway_Homo sapiens_hsa049220.01747635
104Legionellosis_Homo sapiens_hsa05134-0.2241654
105Malaria_Homo sapiens_hsa05144-0.1933701
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1761657
107Lysosome_Homo sapiens_hsa04142-0.1744291
108Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1703494
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1588423
110Insulin signaling pathway_Homo sapiens_hsa04910-0.1422753
111Other glycan degradation_Homo sapiens_hsa00511-0.1398514
112Pyrimidine metabolism_Homo sapiens_hsa00240-0.1335482
113African trypanosomiasis_Homo sapiens_hsa05143-0.1302875
114Regulation of autophagy_Homo sapiens_hsa04140-0.1297370
115Pertussis_Homo sapiens_hsa05133-0.1252848
116Hepatitis C_Homo sapiens_hsa05160-0.1165652
117Renin-angiotensin system_Homo sapiens_hsa04614-0.1154788
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1053624
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0913614
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0607383
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0407185
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0168685
123AMPK signaling pathway_Homo sapiens_hsa04152-0.0089499

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