ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proline transport (GO:0015824)	6.39888291
2	synaptic vesicle maturation (GO:0016188)	6.17566889
3	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.08799091
4	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.97362037
5	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.84436133
6	alanine transport (GO:0032328)	4.68735341
7	estrogen biosynthetic process (GO:0006703)	4.38620980
8	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.37109938
9	cellular potassium ion homeostasis (GO:0030007)	4.36883753
10	cellular ketone body metabolic process (GO:0046950)	4.26797349
11	glutamate secretion (GO:0014047)	4.15930968
12	synaptic vesicle exocytosis (GO:0016079)	4.09929352
13	glycine transport (GO:0015816)	4.05772829
14	detection of calcium ion (GO:0005513)	4.02174862
15	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.00601650
16	long-term synaptic potentiation (GO:0060291)	3.95409612
17	neurotransmitter secretion (GO:0007269)	3.94905111
18	ketone body metabolic process (GO:1902224)	3.78583034
19	sodium ion export (GO:0071436)	3.74529412
20	gamma-aminobutyric acid transport (GO:0015812)	3.71670607
21	signal peptide processing (GO:0006465)	3.66861946
22	negative regulation of receptor-mediated endocytosis (GO:0048261)	3.64714999
23	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.58831870
24	C4-dicarboxylate transport (GO:0015740)	3.54957514
25	regulation of synaptic vesicle exocytosis (GO:2000300)	3.44600639
26	potassium ion homeostasis (GO:0055075)	3.40926464
27	L-amino acid import (GO:0043092)	3.40340842
28	potassium ion import (GO:0010107)	3.40021200
29	neurotransmitter uptake (GO:0001504)	3.38852386
30	neurotransmitter transport (GO:0006836)	3.38240536
31	cell communication involved in cardiac conduction (GO:0086065)	3.37055710
32	photoreceptor cell differentiation (GO:0046530)	3.34282402
33	eye photoreceptor cell differentiation (GO:0001754)	3.34282402
34	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.30125793
35	long term synaptic depression (GO:0060292)	3.23558464
36	brain morphogenesis (GO:0048854)	3.18636274
37	regulation of synaptic vesicle transport (GO:1902803)	3.17532624
38	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.10231914
39	regulation of vesicle fusion (GO:0031338)	3.09878283
40	ATP hydrolysis coupled proton transport (GO:0015991)	3.08146296
41	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.08146296
42	establishment of melanosome localization (GO:0032401)	3.06493884
43	regulation of neurotransmitter levels (GO:0001505)	3.06046287
44	membrane depolarization during action potential (GO:0086010)	3.05663009
45	cellular sodium ion homeostasis (GO:0006883)	3.04178404
46	presynaptic membrane assembly (GO:0097105)	3.01838313
47	startle response (GO:0001964)	3.01343539
48	melanosome transport (GO:0032402)	2.99642694
49	nonmotile primary cilium assembly (GO:0035058)	2.99238674
50	L-serine transport (GO:0015825)	2.98650278
51	locomotory exploration behavior (GO:0035641)	2.97775265
52	regulation of heart rate by cardiac conduction (GO:0086091)	2.97182016
53	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.93595732
54	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.93595732
55	transferrin transport (GO:0033572)	2.92697651
56	trivalent inorganic cation transport (GO:0072512)	2.90541385
57	ferric iron transport (GO:0015682)	2.90541385
58	dendritic spine morphogenesis (GO:0060997)	2.90265943
59	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.89959633
60	establishment of pigment granule localization (GO:0051905)	2.88270854
61	response to dietary excess (GO:0002021)	2.86564052
62	neuron-neuron synaptic transmission (GO:0007270)	2.86055375
63	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.84113801
64	serotonin metabolic process (GO:0042428)	2.83701493
65	neuronal action potential propagation (GO:0019227)	2.82831172
66	pigment granule transport (GO:0051904)	2.80902762
67	cell wall macromolecule catabolic process (GO:0016998)	2.80226077
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.79194949
69	cell communication by electrical coupling (GO:0010644)	2.75291312
70	regulation of gonadotropin secretion (GO:0032276)	2.72941606
71	neuromuscular process controlling posture (GO:0050884)	2.68021823
72	vesicle transport along microtubule (GO:0047496)	2.66019869
73	regulation of glucokinase activity (GO:0033131)	2.65655007
74	regulation of hexokinase activity (GO:1903299)	2.65655007
75	glutamate receptor signaling pathway (GO:0007215)	2.65638219
76	chemosensory behavior (GO:0007635)	2.65367889
77	regulation of neuronal synaptic plasticity (GO:0048168)	2.62168286
78	amino acid import (GO:0043090)	2.61697565
79	succinate metabolic process (GO:0006105)	2.61597762
80	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.60562319
81	dendritic spine organization (GO:0097061)	2.60480973
82	presynaptic membrane organization (GO:0097090)	2.58720181
83	positive regulation of meiosis (GO:0045836)	2.56225670
84	epithelial cell fate commitment (GO:0072148)	2.55571316
85	positive regulation of meiotic cell cycle (GO:0051446)	2.55158211
86	response to insecticide (GO:0017085)	2.53816427
87	vesicle localization (GO:0051648)	2.53778137
88	estrogen metabolic process (GO:0008210)	2.53731514
89	exploration behavior (GO:0035640)	2.53055566
90	regulation of receptor internalization (GO:0002090)	2.52581737
91	melanosome localization (GO:0032400)	2.51548717
92	signal release (GO:0023061)	2.49359721
93	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.49293767
94	neuronal action potential (GO:0019228)	2.49095595
95	cardiac conduction (GO:0061337)	2.49062478
96	glucocorticoid biosynthetic process (GO:0006704)	2.47233928
97	lactate metabolic process (GO:0006089)	2.46815142
98	neurotransmitter biosynthetic process (GO:0042136)	2.45162811
99	cellular potassium ion transport (GO:0071804)	2.44829143
100	potassium ion transmembrane transport (GO:0071805)	2.44829143

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.07493578
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.07352106
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.87042931
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75361291
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.66252352
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.57015843
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.33428645
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.23760720
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13960440
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08676580
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.06167352
12	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.02131946
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.98203395
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90652628
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89352212
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.87726076
17	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.86183421
18	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.86138755
19	P300_19829295_ChIP-Seq_ESCs_Human	1.84658753
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.81312758
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79918817
22	REST_21632747_ChIP-Seq_MESCs_Mouse	1.79729389
23	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.76166167
24	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.76002712
25	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.72173675
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.71402613
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71004840
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67162948
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.66172197
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66172197
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.65666751
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65629000
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65365606
34	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.65278355
35	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.58690797
36	AR_25329375_ChIP-Seq_VCAP_Human	1.55571235
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53120569
38	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.52390266
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49847066
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49106223
41	STAT3_23295773_ChIP-Seq_U87_Human	1.48479412
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47909790
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43881296
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.43576067
45	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.41918637
46	TCF4_23295773_ChIP-Seq_U87_Human	1.40728404
47	FUS_26573619_Chip-Seq_HEK293_Human	1.40326123
48	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.38506416
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34801699
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33831238
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32757054
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31506155
53	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.30675883
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29893281
55	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.28413069
56	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.27809730
57	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.24014734
58	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.22932449
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22801787
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21210046
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20693572
62	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.20149692
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.20075709
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19688014
65	AHR_22903824_ChIP-Seq_MCF-7_Human	1.19167976
66	VDR_22108803_ChIP-Seq_LS180_Human	1.19042730
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18363037
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17430023
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.17312056
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.16393389
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14756170
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.14748318
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14261072
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14237869
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12569271
76	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11862533
77	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11395111
78	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10543884
79	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10477670
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.10349052
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09225792
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09225792
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.09201787
84	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08991084
85	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.07920265
86	JUN_21703547_ChIP-Seq_K562_Human	1.07632978
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07075656
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07075656
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04983388
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.03982232
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03859901
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03214293
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03038768
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01317797
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00757486
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00169456
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99763637
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99500030
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99228505
100	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98637618

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	3.67307173
2	MP0009046_muscle_twitch	3.55615469
3	MP0000013_abnormal_adipose_tissue	3.20116375
4	MP0004270_analgesia	3.14581632
5	MP0009745_abnormal_behavioral_response	2.98453799
6	MP0002064_seizures	2.84526634
7	MP0001984_abnormal_olfaction	2.57700193
8	MP0003880_abnormal_central_pattern	2.55339600
9	MP0001501_abnormal_sleep_pattern	2.50922229
10	MP0002822_catalepsy	2.34224951
11	MP0002837_dystrophic_cardiac_calcinosis	2.32582052
12	MP0004859_abnormal_synaptic_plasticity	2.29990663
13	MP0003123_paternal_imprinting	2.23006412
14	MP0003635_abnormal_synaptic_transmissio	2.18674625
15	MP0005379_endocrine/exocrine_gland_phen	2.14114359
16	MP0002272_abnormal_nervous_system	2.09636729
17	MP0002638_abnormal_pupillary_reflex	2.08538197
18	MP0002909_abnormal_adrenal_gland	1.99559412
19	MP0005423_abnormal_somatic_nervous	1.96681914
20	MP0003122_maternal_imprinting	1.94444118
21	MP0001486_abnormal_startle_reflex	1.82334936
22	MP0005645_abnormal_hypothalamus_physiol	1.79858535
23	MP0002063_abnormal_learning/memory/cond	1.78422467
24	MP0005187_abnormal_penis_morphology	1.77663088
25	MP0001756_abnormal_urination	1.77152730
26	MP0000427_abnormal_hair_cycle	1.74881607
27	MP0002876_abnormal_thyroid_physiology	1.73381539
28	MP0002734_abnormal_mechanical_nocicepti	1.72291185
29	MP0002572_abnormal_emotion/affect_behav	1.72222264
30	MP0002733_abnormal_thermal_nociception	1.71193076
31	MP0001968_abnormal_touch/_nociception	1.70544554
32	MP0006276_abnormal_autonomic_nervous	1.70496946
33	MP0003195_calcinosis	1.70069197
34	MP0002163_abnormal_gland_morphology	1.69027692
35	MP0005386_behavior/neurological_phenoty	1.66975958
36	MP0004924_abnormal_behavior	1.66975958
37	MP0003121_genomic_imprinting	1.66973941
38	MP0004147_increased_porphyrin_level	1.64058035
39	MP0003633_abnormal_nervous_system	1.63943647
40	MP0003787_abnormal_imprinting	1.63634563
41	MP0004043_abnormal_pH_regulation	1.63085095
42	MP0008877_abnormal_DNA_methylation	1.61581067
43	MP0010234_abnormal_vibrissa_follicle	1.58654177
44	MP0010678_abnormal_skin_adnexa	1.51952872
45	MP0008875_abnormal_xenobiotic_pharmacok	1.49370970
46	MP0002067_abnormal_sensory_capabilities	1.48329502
47	MP0002735_abnormal_chemical_nociception	1.47535045
48	MP0000383_abnormal_hair_follicle	1.44620148
49	MP0008872_abnormal_physiological_respon	1.44380123
50	MP0002557_abnormal_social/conspecific_i	1.38949523
51	MP0001502_abnormal_circadian_rhythm	1.36815527
52	MP0005646_abnormal_pituitary_gland	1.34496958
53	MP0004019_abnormal_vitamin_homeostasis	1.32056675
54	MP0001970_abnormal_pain_threshold	1.31715791
55	MP0008995_early_reproductive_senescence	1.29521497
56	MP0005365_abnormal_bile_salt	1.27556909
57	MP0009780_abnormal_chondrocyte_physiolo	1.24248270
58	MP0001440_abnormal_grooming_behavior	1.23157623
59	MP0002254_reproductive_system_inflammat	1.22017165
60	MP0003631_nervous_system_phenotype	1.19398785
61	MP0010386_abnormal_urinary_bladder	1.19207232
62	MP0000647_abnormal_sebaceous_gland	1.18018570
63	MP0001986_abnormal_taste_sensitivity	1.16709216
64	MP0004085_abnormal_heartbeat	1.13576651
65	MP0002295_abnormal_pulmonary_circulatio	1.09864575
66	MP0004885_abnormal_endolymph	1.07016271
67	MP0010329_abnormal_lipoprotein_level	1.06798994
68	MP0000516_abnormal_urinary_system	1.06443482
69	MP0005367_renal/urinary_system_phenotyp	1.06443482
70	MP0002736_abnormal_nociception_after	1.06402396
71	MP0004215_abnormal_myocardial_fiber	1.03778504
72	MP0001765_abnormal_ion_homeostasis	1.02285238
73	MP0005551_abnormal_eye_electrophysiolog	1.00859786
74	MP0005253_abnormal_eye_physiology	0.99847514
75	MP0000538_abnormal_urinary_bladder	0.98769277
76	MP0005535_abnormal_body_temperature	0.97342479
77	MP0001905_abnormal_dopamine_level	0.95537494
78	MP0000639_abnormal_adrenal_gland	0.94684752
79	MP0002066_abnormal_motor_capabilities/c	0.93890678
80	MP0003283_abnormal_digestive_organ	0.93034561
81	MP0000003_abnormal_adipose_tissue	0.92909172
82	MP0002069_abnormal_eating/drinking_beha	0.92641756
83	MP0001529_abnormal_vocalization	0.91741639
84	MP0002229_neurodegeneration	0.90573925
85	MP0000569_abnormal_digit_pigmentation	0.88208349
86	MP0004811_abnormal_neuron_physiology	0.86918412
87	MP0006035_abnormal_mitochondrial_morpho	0.86112398
88	MP0006054_spinal_hemorrhage	0.85903684
89	MP0001944_abnormal_pancreas_morphology	0.85264279
90	MP0002078_abnormal_glucose_homeostasis	0.84486040
91	MP0003879_abnormal_hair_cell	0.83658434
92	MP0004142_abnormal_muscle_tone	0.82496618
93	MP0003690_abnormal_glial_cell	0.80575843
94	MP0008775_abnormal_heart_ventricle	0.77891147
95	MP0002693_abnormal_pancreas_physiology	0.76361652
96	MP0006072_abnormal_retinal_apoptosis	0.72446755
97	MP0003136_yellow_coat_color	0.71318069
98	MP0005448_abnormal_energy_balance	0.70937939
99	MP0000920_abnormal_myelination	0.70148376
100	MP0003632_abnormal_nervous_system	0.70094148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Atonic seizures (HP:0010819)	4.85068322
2	Hyperventilation (HP:0002883)	3.82984504
3	Focal motor seizures (HP:0011153)	3.70610965
4	Mutism (HP:0002300)	3.68186041
5	Febrile seizures (HP:0002373)	3.65084201
6	Progressive macrocephaly (HP:0004481)	3.55372063
7	Absence seizures (HP:0002121)	3.40793248
8	Acute necrotizing encephalopathy (HP:0006965)	3.39781235
9	Medial flaring of the eyebrow (HP:0010747)	3.38997165
10	Epileptiform EEG discharges (HP:0011182)	3.34914865
11	Pheochromocytoma (HP:0002666)	3.34608233
12	Generalized tonic-clonic seizures (HP:0002069)	3.29581533
13	Retinal atrophy (HP:0001105)	3.25046303
14	Neuroendocrine neoplasm (HP:0100634)	3.10377198
15	EEG with generalized epileptiform discharges (HP:0011198)	3.10338841
16	Gaze-evoked nystagmus (HP:0000640)	3.08374487
17	Dialeptic seizures (HP:0011146)	3.06824228
18	Hypsarrhythmia (HP:0002521)	3.00276538
19	Mitral stenosis (HP:0001718)	2.94558521
20	Testicular neoplasm (HP:0010788)	2.93651828
21	Inappropriate behavior (HP:0000719)	2.92726608
22	Acute encephalopathy (HP:0006846)	2.86719358
23	Myokymia (HP:0002411)	2.86298462
24	Drooling (HP:0002307)	2.84896208
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.84503481
26	Focal seizures (HP:0007359)	2.79923136
27	Gait imbalance (HP:0002141)	2.72655261
28	Growth hormone excess (HP:0000845)	2.66834685
29	Excessive salivation (HP:0003781)	2.61779564
30	Inability to walk (HP:0002540)	2.61414004
31	Attenuation of retinal blood vessels (HP:0007843)	2.61071140
32	Congenital primary aphakia (HP:0007707)	2.57655647
33	Hypothermia (HP:0002045)	2.53506314
34	Hemiparesis (HP:0001269)	2.51548134
35	Papillary thyroid carcinoma (HP:0002895)	2.50070414
36	Epileptic encephalopathy (HP:0200134)	2.47777927
37	Hypomagnesemia (HP:0002917)	2.41771698
38	Agitation (HP:0000713)	2.41723079
39	Increased circulating renin level (HP:0000848)	2.40155310
40	Syncope (HP:0001279)	2.39381439
41	Generalized myoclonic seizures (HP:0002123)	2.38345059
42	Amblyopia (HP:0000646)	2.28888768
43	Intention tremor (HP:0002080)	2.28114760
44	Tongue fasciculations (HP:0001308)	2.27679914
45	Ketoacidosis (HP:0001993)	2.26971871
46	Thyroid carcinoma (HP:0002890)	2.26868678
47	Anxiety (HP:0000739)	2.25448375
48	Ankle clonus (HP:0011448)	2.18534838
49	Mitochondrial inheritance (HP:0001427)	2.18338805
50	Nephrogenic diabetes insipidus (HP:0009806)	2.18067371
51	Supranuclear gaze palsy (HP:0000605)	2.16034352
52	Abnormality of the fovea (HP:0000493)	2.15579777
53	Male infertility (HP:0003251)	2.15080167
54	Postural instability (HP:0002172)	2.13354029
55	Depression (HP:0000716)	2.13034377
56	Abnormality of midbrain morphology (HP:0002418)	2.12756499
57	Molar tooth sign on MRI (HP:0002419)	2.12756499
58	Aqueductal stenosis (HP:0002410)	2.11111979
59	Fair hair (HP:0002286)	2.08570095
60	Spastic gait (HP:0002064)	2.08418273
61	Abnormal EKG (HP:0003115)	2.01386546
62	Intestinal atresia (HP:0011100)	1.99406308
63	Polydipsia (HP:0001959)	1.98390860
64	Abnormal drinking behavior (HP:0030082)	1.98390860
65	Tetraplegia (HP:0002445)	1.97988454
66	Protruding tongue (HP:0010808)	1.97279030
67	Muscular hypotonia of the trunk (HP:0008936)	1.96396663
68	Central scotoma (HP:0000603)	1.96220474
69	Zonular cataract (HP:0010920)	1.95454727
70	Muscle fibrillation (HP:0010546)	1.92604608
71	Hemiplegia (HP:0002301)	1.91470928
72	Prolonged QT interval (HP:0001657)	1.90908901
73	Urinary urgency (HP:0000012)	1.90679347
74	Bradykinesia (HP:0002067)	1.89326642
75	Dyskinesia (HP:0100660)	1.88038626
76	Apathy (HP:0000741)	1.84506857
77	Pancreatic fibrosis (HP:0100732)	1.84309969
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.83805408
79	Cerebral edema (HP:0002181)	1.83762951
80	Broad-based gait (HP:0002136)	1.83171591
81	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.82045566
82	Blue irides (HP:0000635)	1.81332612
83	Widely spaced teeth (HP:0000687)	1.81256334
84	Generalized hypopigmentation of hair (HP:0011358)	1.81238421
85	Abnormality of magnesium homeostasis (HP:0004921)	1.80685773
86	Scotoma (HP:0000575)	1.80656107
87	Neoplasm of the peripheral nervous system (HP:0100007)	1.79931897
88	Right ventricular cardiomyopathy (HP:0011663)	1.78927797
89	Sensorimotor neuropathy (HP:0007141)	1.78674142
90	Lower limb muscle weakness (HP:0007340)	1.78041250
91	Truncal ataxia (HP:0002078)	1.77790443
92	True hermaphroditism (HP:0010459)	1.77125835
93	Hamartoma of the eye (HP:0010568)	1.76829105
94	Absent speech (HP:0001344)	1.76532415
95	Spastic tetraplegia (HP:0002510)	1.74764495
96	Vaginal atresia (HP:0000148)	1.73483103
97	Abnormality of saccadic eye movements (HP:0000570)	1.72969045
98	Abnormal eating behavior (HP:0100738)	1.72940383
99	Optic disc pallor (HP:0000543)	1.72574014
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.72018734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.72749191
2	PDK2	3.15920253
3	CASK	3.04562339
4	MAP3K9	2.92030858
5	MAP3K4	2.59885398
6	FGFR2	2.59722118
7	LMTK2	2.35683720
8	NTRK3	2.24305293
9	EPHA4	2.10245534
10	ACVR1B	1.86797677
11	NME1	1.74143754
12	MAP2K7	1.70126478
13	MAP3K12	1.66185190
14	PHKG2	1.62774921
15	PHKG1	1.62774921
16	PINK1	1.62507890
17	MARK1	1.51853913
18	BMPR2	1.50668633
19	FGR	1.47501083
20	PAK3	1.42691727
21	SGK2	1.37262510
22	STK38L	1.29830127
23	MAP4K2	1.26760143
24	STK16	1.26617374
25	NEK6	1.24530202
26	MAPK13	1.21667796
27	PRKCE	1.19431088
28	DAPK2	1.19091729
29	FER	1.16775052
30	PRKCG	1.05542158
31	TAF1	1.04847310
32	PTK2B	1.03185486
33	CAMKK2	0.98221013
34	AKT3	0.97041332
35	PIK3CA	0.96228523
36	BCKDK	0.95097671
37	FGFR3	0.94361082
38	SGK223	0.91980838
39	SGK494	0.91980838
40	PAK6	0.91774562
41	CAMK1	0.91010052
42	CAMK2A	0.90639501
43	EPHA3	0.90119176
44	DDR2	0.89200915
45	NTRK2	0.88980759
46	PRKD3	0.88706332
47	CAMK4	0.85345135
48	CDK5	0.84595290
49	EPHB1	0.84535660
50	IRAK1	0.79292827
51	MAP3K13	0.79290950
52	STK38	0.78034489
53	NLK	0.77029358
54	STK11	0.76922193
55	SGK3	0.76847074
56	CSNK1G2	0.76050398
57	CAMK2D	0.75039369
58	TSSK6	0.72570918
59	UHMK1	0.72217795
60	CSNK1G1	0.71487439
61	MAP2K4	0.70144338
62	CDK3	0.68217657
63	CAMK2B	0.68057639
64	GRK1	0.67617790
65	PRKCH	0.65953849
66	PLK2	0.65008899
67	RIPK4	0.61769173
68	RPS6KA5	0.60894156
69	PRKAA2	0.60801611
70	ADRBK2	0.59973514
71	MAP3K7	0.59931880
72	SGK1	0.59136422
73	CSNK1G3	0.59048158
74	CSNK1A1	0.58490598
75	MINK1	0.56972496
76	RPS6KA4	0.51780129
77	TAOK1	0.51345957
78	PRKACB	0.50199936
79	PRKG1	0.49193553
80	CSNK1A1L	0.48843685
81	TAOK3	0.48837263
82	MAPK7	0.48512811
83	PRKAA1	0.47819273
84	NUAK1	0.47705855
85	PRKD2	0.47680648
86	OXSR1	0.46665107
87	PRKCA	0.46589289
88	PRKACA	0.46282561
89	ALK	0.45865872
90	TNIK	0.45147778
91	INSRR	0.45110032
92	BCR	0.44842740
93	PRKG2	0.43405071
94	CSNK1D	0.37802132
95	RPS6KA3	0.37440403
96	NEK1	0.36080514
97	PTK2	0.34306399
98	PIK3CG	0.33941916
99	AKT2	0.33886743
100	MATK	0.31634564

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.53886603
2	Butanoate metabolism_Homo sapiens_hsa00650	3.27953220
3	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.22258326
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.82967761
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.72158110
6	GABAergic synapse_Homo sapiens_hsa04727	2.60206699
7	Insulin secretion_Homo sapiens_hsa04911	2.57557435
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43002939
9	Protein export_Homo sapiens_hsa03060	2.34208193
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.11036826
11	Taste transduction_Homo sapiens_hsa04742	2.08204911
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.05749017
13	Circadian entrainment_Homo sapiens_hsa04713	1.93567967
14	Vibrio cholerae infection_Homo sapiens_hsa05110	1.90869710
15	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.88663772
16	Morphine addiction_Homo sapiens_hsa05032	1.84165824
17	Circadian rhythm_Homo sapiens_hsa04710	1.82380000
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.74385076
19	Mineral absorption_Homo sapiens_hsa04978	1.73452307
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.73029710
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.53482823
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.48223394
23	Amphetamine addiction_Homo sapiens_hsa05031	1.38852842
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.38745274
25	Sulfur metabolism_Homo sapiens_hsa00920	1.33361236
26	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.32400048
27	Bile secretion_Homo sapiens_hsa04976	1.31261266
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.30435256
29	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.27929225
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.27390181
31	Salivary secretion_Homo sapiens_hsa04970	1.24271940
32	Regulation of autophagy_Homo sapiens_hsa04140	1.23020228
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.22734283
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.17449894
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12813443
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12479357
37	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.10751809
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08756320
39	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06837761
40	Cocaine addiction_Homo sapiens_hsa05030	1.05396729
41	Olfactory transduction_Homo sapiens_hsa04740	1.03594274
42	Oxidative phosphorylation_Homo sapiens_hsa00190	1.01386162
43	Renin secretion_Homo sapiens_hsa04924	1.00207902
44	Propanoate metabolism_Homo sapiens_hsa00640	0.99759933
45	Gastric acid secretion_Homo sapiens_hsa04971	0.98308070
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98232447
47	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.93372834
48	Pancreatic secretion_Homo sapiens_hsa04972	0.89424639
49	Sphingolipid metabolism_Homo sapiens_hsa00600	0.88816456
50	Fatty acid elongation_Homo sapiens_hsa00062	0.87191667
51	Serotonergic synapse_Homo sapiens_hsa04726	0.83052409
52	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.82580945
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82188953
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.81108668
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.81020914
56	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.80474743
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.80418340
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79835813
59	Long-term potentiation_Homo sapiens_hsa04720	0.73611657
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73086051
61	Phototransduction_Homo sapiens_hsa04744	0.71314074
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68762015
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66222838
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66011213
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.65679139
66	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.65181464
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.63632768
68	ABC transporters_Homo sapiens_hsa02010	0.62275495
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60617279
70	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.57850341
71	Peroxisome_Homo sapiens_hsa04146	0.57383856
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.55381800
73	Folate biosynthesis_Homo sapiens_hsa00790	0.55375877
74	Lysosome_Homo sapiens_hsa04142	0.54190865
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50253161
76	Cholinergic synapse_Homo sapiens_hsa04725	0.49776612
77	Parkinsons disease_Homo sapiens_hsa05012	0.49151540
78	Long-term depression_Homo sapiens_hsa04730	0.48106362
79	Complement and coagulation cascades_Homo sapiens_hsa04610	0.46993042
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.46625167
81	PPAR signaling pathway_Homo sapiens_hsa03320	0.41813167
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41685817
83	Sulfur relay system_Homo sapiens_hsa04122	0.40668996
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39240926
85	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38330377
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37877461
87	Retinol metabolism_Homo sapiens_hsa00830	0.36982079
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.34964151
89	Tight junction_Homo sapiens_hsa04530	0.34879081
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34704237
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.33303906
92	Metabolic pathways_Homo sapiens_hsa01100	0.32122442
93	Gap junction_Homo sapiens_hsa04540	0.31347106
94	Fatty acid degradation_Homo sapiens_hsa00071	0.31273094
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.30687662
96	Protein digestion and absorption_Homo sapiens_hsa04974	0.30590972
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30308552
98	Phagosome_Homo sapiens_hsa04145	0.30144688
99	Caffeine metabolism_Homo sapiens_hsa00232	0.28784635
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28241744

HSD3BP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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