HSD3BP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1receptor catabolic process (GO:0032801)5.83067248
2proline biosynthetic process (GO:0006561)5.32539196
3CDP-diacylglycerol biosynthetic process (GO:0016024)5.28937693
4dorsal/ventral axis specification (GO:0009950)5.16913794
5righting reflex (GO:0060013)4.95914953
6positive regulation of respiratory burst (GO:0060267)4.88710829
7detection of calcium ion (GO:0005513)4.63635702
8CDP-diacylglycerol metabolic process (GO:0046341)4.59372168
9positive regulation of glycolytic process (GO:0045821)4.56826668
10iron ion import (GO:0097286)4.42502584
11inner mitochondrial membrane organization (GO:0007007)4.42235798
12brain morphogenesis (GO:0048854)4.31496329
13regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.23877089
14nonmotile primary cilium assembly (GO:0035058)4.16005550
15regulation of type B pancreatic cell apoptotic process (GO:2000674)4.15691712
16estrogen biosynthetic process (GO:0006703)4.15601927
17astrocyte differentiation (GO:0048708)4.11903112
18protein localization to Golgi apparatus (GO:0034067)4.10499465
19positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.10385202
20regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.10385202
21epithelial cell fate commitment (GO:0072148)4.06172088
22toxin metabolic process (GO:0009404)3.96657715
23peptidyl-cysteine modification (GO:0018198)3.85670275
24regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.84001734
25proline metabolic process (GO:0006560)3.80477987
26negative regulation of dendrite morphogenesis (GO:0050774)3.78719113
27organelle membrane fusion (GO:0090174)3.73310375
28melanosome transport (GO:0032402)3.70230713
29eye photoreceptor cell differentiation (GO:0001754)3.67785484
30photoreceptor cell differentiation (GO:0046530)3.67785484
31attachment of spindle microtubules to kinetochore (GO:0008608)3.65357412
32pigment granule transport (GO:0051904)3.60746326
33signal peptide processing (GO:0006465)3.57465821
34establishment of melanosome localization (GO:0032401)3.52511617
35vascular smooth muscle contraction (GO:0014829)3.49025102
36response to pheromone (GO:0019236)3.48753352
37glycosphingolipid biosynthetic process (GO:0006688)3.47742308
38morphogenesis of an epithelial sheet (GO:0002011)3.46199402
39establishment of pigment granule localization (GO:0051905)3.44209990
40renal tubule development (GO:0061326)3.43855275
41negative regulation of acute inflammatory response (GO:0002674)3.43540233
42tyrosine metabolic process (GO:0006570)3.43019639
43autophagic vacuole fusion (GO:0000046)3.40001679
44vesicle transport along microtubule (GO:0047496)3.38686458
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.38569976
46exocrine pancreas development (GO:0031017)3.25907091
47macroautophagy (GO:0016236)3.24878304
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.24376448
49dendritic spine morphogenesis (GO:0060997)3.23320743
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16752474
51positive regulation of growth hormone secretion (GO:0060124)3.14590848
52import into cell (GO:0098657)3.11152433
53negative regulation of dendrite development (GO:2000171)3.09732005
54histamine secretion (GO:0001821)3.08588383
55male sex determination (GO:0030238)3.05128675
56melanosome localization (GO:0032400)3.04524230
57long term synaptic depression (GO:0060292)3.00854089
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00771600
59L-phenylalanine catabolic process (GO:0006559)3.00771600
60pigment granule localization (GO:0051875)2.98806229
61type B pancreatic cell development (GO:0003323)2.97917319
62glycosylceramide metabolic process (GO:0006677)2.94918484
63glandular epithelial cell development (GO:0002068)2.92021424
64regulation of acyl-CoA biosynthetic process (GO:0050812)2.88766617
65early endosome to late endosome transport (GO:0045022)2.87505213
66ferric iron transport (GO:0015682)2.86827374
67trivalent inorganic cation transport (GO:0072512)2.86827374
68positive regulation of Rap GTPase activity (GO:0032854)2.85521888
69atrial cardiac muscle cell action potential (GO:0086014)2.84816003
70endosome to lysosome transport (GO:0008333)2.84064513
71ovulation from ovarian follicle (GO:0001542)2.83626284
72protein targeting to Golgi (GO:0000042)2.82441025
73vesicle localization (GO:0051648)2.82071082
74establishment of protein localization to Golgi (GO:0072600)2.81833665
75response to methylmercury (GO:0051597)2.77455001
76dendritic spine organization (GO:0097061)2.76992440
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76089360
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76089360
79positive regulation of mitotic sister chromatid separation (GO:1901970)2.76089360
80synaptic vesicle maturation (GO:0016188)2.74424853
81cellular response to gamma radiation (GO:0071480)2.73617803
82growth hormone secretion (GO:0030252)2.72683764
83peptidyl-tyrosine autophosphorylation (GO:0038083)2.72019478
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69262105
85transferrin transport (GO:0033572)2.68507459
86regulation of clathrin-mediated endocytosis (GO:2000369)2.61875246
87artery smooth muscle contraction (GO:0014824)2.60293934
88presynaptic membrane assembly (GO:0097105)2.60138615
89L-phenylalanine metabolic process (GO:0006558)2.59590113
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59590113
91metanephric tubule development (GO:0072170)2.58730740
92metanephric nephron tubule development (GO:0072234)2.58730740
93cellular ketone body metabolic process (GO:0046950)2.58571555
94negative regulation of focal adhesion assembly (GO:0051895)2.55311802
95negative regulation of cell junction assembly (GO:1901889)2.55311802
96negative regulation of adherens junction organization (GO:1903392)2.55311802
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55160878
98positive regulation of glycogen biosynthetic process (GO:0045725)2.54096709
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53382280
100regulation of cofactor metabolic process (GO:0051193)2.52147164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.26542124
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.42342909
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.15635809
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09513214
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66439189
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.62541445
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45059422
8AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.42380256
9GBX2_23144817_ChIP-Seq_PC3_Human2.37119435
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31819973
11IGF1R_20145208_ChIP-Seq_DFB_Human2.30456426
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.23671499
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14933164
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05318821
15TAF15_26573619_Chip-Seq_HEK293_Human2.02334335
16P300_19829295_ChIP-Seq_ESCs_Human2.01193367
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.94208206
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.91984684
19FUS_26573619_Chip-Seq_HEK293_Human1.87244725
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85162885
21ZNF274_21170338_ChIP-Seq_K562_Hela1.83858777
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79362663
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77688576
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.75773746
25BCAT_22108803_ChIP-Seq_LS180_Human1.75293790
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74850482
27AR_25329375_ChIP-Seq_VCAP_Human1.67863291
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67444427
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66686110
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60274855
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60136805
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58895063
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58693097
34SMAD4_21799915_ChIP-Seq_A2780_Human1.58179129
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56118678
36ER_23166858_ChIP-Seq_MCF-7_Human1.48463877
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.47756766
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.47481124
39VDR_22108803_ChIP-Seq_LS180_Human1.46532701
40STAT3_23295773_ChIP-Seq_U87_Human1.44765949
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42976207
42CBP_20019798_ChIP-Seq_JUKART_Human1.42976207
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41498172
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41425550
45CMYC_18555785_Chip-Seq_ESCs_Mouse1.40242167
46RXR_22108803_ChIP-Seq_LS180_Human1.39558895
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38920764
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37833654
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.36281941
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.35637304
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34780805
52TCF4_23295773_ChIP-Seq_U87_Human1.34240327
53CJUN_26792858_Chip-Seq_BT549_Human1.32931163
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.31705880
55CTCF_18555785_Chip-Seq_ESCs_Mouse1.30390531
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.29229636
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28293112
58TCF4_22108803_ChIP-Seq_LS180_Human1.28291719
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.26218123
60P53_22387025_ChIP-Seq_ESCs_Mouse1.25963775
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.24869603
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23442894
63AHR_22903824_ChIP-Seq_MCF-7_Human1.19904200
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.19828548
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17324256
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17324256
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17192987
68CDX2_22108803_ChIP-Seq_LS180_Human1.16697443
69P300_18555785_Chip-Seq_ESCs_Mouse1.15867284
70NMYC_18555785_Chip-Seq_ESCs_Mouse1.15758280
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15287893
72BRD4_25478319_ChIP-Seq_HGPS_Human1.12136957
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12105842
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11311261
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10935451
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10897870
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10022771
78SOX2_18555785_Chip-Seq_ESCs_Mouse1.08797147
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08667671
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07612883
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07612883
82RUNX2_22187159_ChIP-Seq_PCA_Human1.07330503
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06798560
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04780104
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04495046
86SOX2_19829295_ChIP-Seq_ESCs_Human1.03978537
87NANOG_19829295_ChIP-Seq_ESCs_Human1.03978537
88KLF4_18555785_Chip-Seq_ESCs_Mouse1.03749401
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03593768
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03523697
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.03333797
92SALL4_22934838_ChIP-ChIP_CD34+_Human1.02773219
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01704596
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.01053376
95TFEB_21752829_ChIP-Seq_HELA_Human0.98745819
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98120829
97TP63_23658742_ChIP-Seq_EP156T_Human0.96120881
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.96106966
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94513371
100ZFX_18555785_Chip-Seq_ESCs_Mouse0.93857471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.91450420
2MP0010678_abnormal_skin_adnexa4.13830146
3MP0002837_dystrophic_cardiac_calcinosis3.83640555
4MP0002638_abnormal_pupillary_reflex3.57982984
5MP0000383_abnormal_hair_follicle3.47295189
6MP0003283_abnormal_digestive_organ3.47147886
7MP0000427_abnormal_hair_cycle3.46274237
8MP0003195_calcinosis3.00293174
9MP0000569_abnormal_digit_pigmentation2.94175498
10MP0003011_delayed_dark_adaptation2.90855666
11MP0002877_abnormal_melanocyte_morpholog2.74643345
12MP0005365_abnormal_bile_salt2.65940115
13MP0009046_muscle_twitch2.48254217
14MP0005379_endocrine/exocrine_gland_phen2.34171222
15MP0005220_abnormal_exocrine_pancreas2.08050098
16MP0002163_abnormal_gland_morphology2.04885708
17MP0003787_abnormal_imprinting2.00217697
18MP0002254_reproductive_system_inflammat1.93241185
19MP0005645_abnormal_hypothalamus_physiol1.89167366
20MP0002090_abnormal_vision1.86981076
21MP0004043_abnormal_pH_regulation1.81894357
22MP0001984_abnormal_olfaction1.75505420
23MP0000013_abnormal_adipose_tissue1.72297177
24MP0002822_catalepsy1.65217655
25MP0005257_abnormal_intraocular_pressure1.64403848
26MP0003172_abnormal_lysosome_physiology1.59186651
27MP0000647_abnormal_sebaceous_gland1.55881003
28MP0005408_hypopigmentation1.53751828
29MP0003252_abnormal_bile_duct1.51614640
30MP0001944_abnormal_pancreas_morphology1.49115689
31MP0004885_abnormal_endolymph1.49103103
32MP0005084_abnormal_gallbladder_morpholo1.42838477
33MP0002876_abnormal_thyroid_physiology1.39291861
34MP0001727_abnormal_embryo_implantation1.38147005
35MP0001756_abnormal_urination1.35851461
36MP0002693_abnormal_pancreas_physiology1.35329197
37MP0003633_abnormal_nervous_system1.34468623
38MP0008775_abnormal_heart_ventricle1.33806074
39MP0010352_gastrointestinal_tract_polyps1.30903160
40MP0005171_absent_coat_pigmentation1.28844728
41MP0001501_abnormal_sleep_pattern1.27427142
42MP0010386_abnormal_urinary_bladder1.25294464
43MP0009745_abnormal_behavioral_response1.16709689
44MP0001440_abnormal_grooming_behavior1.15167604
45MP0008995_early_reproductive_senescence1.14176027
46MP0003828_pulmonary_edema1.10117989
47MP0002139_abnormal_hepatobiliary_system1.09812077
48MP0004134_abnormal_chest_morphology1.09458908
49MP0005174_abnormal_tail_pigmentation1.05910146
50MP0002078_abnormal_glucose_homeostasis1.03234618
51MP0006072_abnormal_retinal_apoptosis1.01385139
52MP0003300_gastrointestinal_ulcer1.00391303
53MP0002928_abnormal_bile_duct1.00140072
54MP0002909_abnormal_adrenal_gland0.97814561
55MP0004381_abnormal_hair_follicle0.97243811
56MP0004270_analgesia0.96361221
57MP0005058_abnormal_lysosome_morphology0.94037458
58MP0005535_abnormal_body_temperature0.91976390
59MP0000015_abnormal_ear_pigmentation0.90939954
60MP0010307_abnormal_tumor_latency0.90851259
61MP0005253_abnormal_eye_physiology0.90800996
62MP0000371_diluted_coat_color0.89117266
63MP0005310_abnormal_salivary_gland0.88229613
64MP0004036_abnormal_muscle_relaxation0.85825821
65MP0004084_abnormal_cardiac_muscle0.84993249
66MP0008877_abnormal_DNA_methylation0.84487761
67MP0006035_abnormal_mitochondrial_morpho0.83785792
68MP0000767_abnormal_smooth_muscle0.81021174
69MP0002064_seizures0.80434450
70MP0000003_abnormal_adipose_tissue0.78629194
71MP0000516_abnormal_urinary_system0.76986731
72MP0005367_renal/urinary_system_phenotyp0.76986731
73MP0009780_abnormal_chondrocyte_physiolo0.76324791
74MP0003122_maternal_imprinting0.75981027
75MP0002572_abnormal_emotion/affect_behav0.72142902
76MP0005448_abnormal_energy_balance0.69691453
77MP0003943_abnormal_hepatobiliary_system0.69445304
78MP0003631_nervous_system_phenotype0.69322009
79MP0005167_abnormal_blood-brain_barrier0.69251043
80MP0004510_myositis0.65628123
81MP0002938_white_spotting0.65592636
82MP0001765_abnormal_ion_homeostasis0.65273908
83MP0000613_abnormal_salivary_gland0.64972551
84MP0004085_abnormal_heartbeat0.64569354
85MP0002295_abnormal_pulmonary_circulatio0.61495070
86MP0001324_abnormal_eye_pigmentation0.60092397
87MP0001929_abnormal_gametogenesis0.59839135
88MP0002970_abnormal_white_adipose0.58249501
89MP0002118_abnormal_lipid_homeostasis0.58112101
90MP0001186_pigmentation_phenotype0.57975173
91MP0000465_gastrointestinal_hemorrhage0.57232576
92MP0005075_abnormal_melanosome_morpholog0.57097316
93MP0003045_fibrosis0.56708937
94MP0003953_abnormal_hormone_level0.56049144
95MP0002971_abnormal_brown_adipose0.54790917
96MP0002063_abnormal_learning/memory/cond0.53136069
97MP0000538_abnormal_urinary_bladder0.52902304
98MP0001485_abnormal_pinna_reflex0.52478385
99MP0005410_abnormal_fertilization0.52418413
100MP0000920_abnormal_myelination0.52412443

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic islet-cell hyperplasia (HP:0004510)6.49477157
2Abnormality of the pancreatic islet cells (HP:0006476)5.36848242
3Abnormality of endocrine pancreas physiology (HP:0012093)5.36848242
4Hypoglycemic seizures (HP:0002173)5.15686085
5Enlarged penis (HP:0000040)5.02660515
6Hyperinsulinemic hypoglycemia (HP:0000825)4.96458850
7Medial flaring of the eyebrow (HP:0010747)4.74121901
8Gaze-evoked nystagmus (HP:0000640)4.64137730
9Dysmetric saccades (HP:0000641)4.49535612
10Hypoglycemic coma (HP:0001325)3.98583036
11Hyperalaninemia (HP:0003348)3.79995060
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.79995060
13Abnormality of alanine metabolism (HP:0010916)3.79995060
14Large for gestational age (HP:0001520)3.73979569
15Hematochezia (HP:0002573)3.68919062
16Ketoacidosis (HP:0001993)3.68138390
17Insulin-resistant diabetes mellitus (HP:0000831)3.64087070
18Long foot (HP:0001833)3.45994724
19Sensorimotor neuropathy (HP:0007141)3.31100678
20Hydroureter (HP:0000072)3.31047024
21Hyperglycemia (HP:0003074)3.22124615
22Symptomatic seizures (HP:0011145)3.19108047
23Gait imbalance (HP:0002141)3.18693821
24Congenital primary aphakia (HP:0007707)3.14105610
25Male infertility (HP:0003251)3.00726511
26Congenital, generalized hypertrichosis (HP:0004540)2.97883910
27Thick nail (HP:0001805)2.96477229
28Increased intramyocellular lipid droplets (HP:0012240)2.89154620
29Hypomagnesemia (HP:0002917)2.71372513
30Zonular cataract (HP:0010920)2.70421651
31Renal Fanconi syndrome (HP:0001994)2.70386721
32Attenuation of retinal blood vessels (HP:0007843)2.68335365
33Nephrogenic diabetes insipidus (HP:0009806)2.62765175
34Hyperventilation (HP:0002883)2.57429648
35Urethral obstruction (HP:0000796)2.55328616
36Abnormal rod and cone electroretinograms (HP:0008323)2.51034349
37Neoplasm of the adrenal cortex (HP:0100641)2.46480457
38Intestinal atresia (HP:0011100)2.45475732
39Limb ataxia (HP:0002070)2.45297338
40Generalized hyperpigmentation (HP:0007440)2.43791602
41Spastic paraparesis (HP:0002313)2.41539517
42Increased muscle lipid content (HP:0009058)2.40761515
43Progressive hearing impairment (HP:0001730)2.37886252
44Aqueductal stenosis (HP:0002410)2.37365318
45Coronal craniosynostosis (HP:0004440)2.34933931
46Barrel-shaped chest (HP:0001552)2.33615685
47Thickened helices (HP:0000391)2.32375005
48Conjunctival hamartoma (HP:0100780)2.30147619
49Poor coordination (HP:0002370)2.24858748
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22165431
51Increased circulating renin level (HP:0000848)2.21739725
52Truncal ataxia (HP:0002078)2.17966356
53Progressive sensorineural hearing impairment (HP:0000408)2.16403718
54Oculomotor apraxia (HP:0000657)2.15327508
55Furrowed tongue (HP:0000221)2.14147283
56Short foot (HP:0001773)2.14068262
57Hypophosphatemic rickets (HP:0004912)2.13215818
58Nuclear cataract (HP:0100018)2.12852693
59Lower limb hyperreflexia (HP:0002395)2.12631102
60Vaginal atresia (HP:0000148)2.11644485
61Abnormality of saccadic eye movements (HP:0000570)2.11201055
62Volvulus (HP:0002580)2.07638894
63Aplasia/Hypoplasia of the lens (HP:0008063)2.07191166
64Mutism (HP:0002300)2.06602230
65Genital tract atresia (HP:0001827)2.06277891
66Tubulointerstitial fibrosis (HP:0005576)2.05549391
67Abnormality of magnesium homeostasis (HP:0004921)2.04572868
68Ketosis (HP:0001946)2.04349336
69Hamartoma of the eye (HP:0010568)2.01938864
70Testicular neoplasm (HP:0010788)2.00446502
71Tubulointerstitial abnormality (HP:0001969)1.99188396
72Polydipsia (HP:0001959)1.99172121
73Abnormal drinking behavior (HP:0030082)1.99172121
74Dysdiadochokinesis (HP:0002075)1.98575770
75Generalized myoclonic seizures (HP:0002123)1.97785814
76Abnormality of liposaccharide metabolism (HP:0010968)1.94881744
77Abnormality of glycosphingolipid metabolism (HP:0004343)1.94881744
78Abnormality of glycolipid metabolism (HP:0010969)1.94881744
79Hypoplasia of the fovea (HP:0007750)1.89904336
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.89904336
81Amblyopia (HP:0000646)1.89397959
82Large eyes (HP:0001090)1.88988080
83Disproportionate short-trunk short stature (HP:0003521)1.86597551
84Paraparesis (HP:0002385)1.84189307
85Stomatitis (HP:0010280)1.81378953
86Polycystic ovaries (HP:0000147)1.80238410
87Slow saccadic eye movements (HP:0000514)1.78563405
88J-shaped sella turcica (HP:0002680)1.77452287
89Increased density of long bones (HP:0006392)1.76897316
90Abnormality of renal resorption (HP:0011038)1.72602617
91EEG with generalized epileptiform discharges (HP:0011198)1.70038448
92Epileptiform EEG discharges (HP:0011182)1.69690949
93Bone cyst (HP:0012062)1.67057751
94Confusion (HP:0001289)1.66424117
95Cone-rod dystrophy (HP:0000548)1.66230426
96Large hands (HP:0001176)1.65246499
97Short chin (HP:0000331)1.63523596
98Cutaneous melanoma (HP:0012056)1.63000294
99Progressive external ophthalmoplegia (HP:0000590)1.62608270
100Neoplasm of the adrenal gland (HP:0100631)1.61814845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.25234313
2INSRR6.72683884
3TAF16.06029538
4ACVR1B5.39899956
5FGFR23.40922741
6BMPR22.28448132
7PTK2B2.09882655
8MAP3K132.01501489
9MAP3K41.94023921
10SGK21.92801444
11MAP3K91.86192624
12FGR1.84168098
13SGK31.75226811
14FGFR31.65845656
15ERBB31.55014999
16FER1.47809805
17ARAF1.28524742
18NTRK31.27805677
19SGK4941.27260410
20SGK2231.27260410
21SIK21.12935106
22DAPK21.11339183
23KSR21.05603396
24TIE10.95071235
25TRPM70.93801603
26CDK30.91240252
27ADRBK20.88665362
28NLK0.87181483
29CASK0.84424447
30MAP3K30.78396786
31MOS0.77470085
32MAPK110.76948543
33KSR10.73925419
34PRKCH0.73184782
35PLK20.71650428
36PTK20.69767022
37TAOK30.69735069
38STK390.69071652
39TAOK10.67106472
40IRAK30.65404468
41EPHA30.64736354
42RAF10.64523843
43CSNK1G10.62320733
44PINK10.61715314
45STK40.60856809
46MAP3K20.58812997
47ICK0.58067254
48PRKCE0.55643306
49GSK3A0.55559409
50MAP4K20.53671790
51SGK10.52579992
52HIPK20.51732980
53ABL20.50410698
54PRKAA20.50188655
55OXSR10.49101335
56DDR20.48049105
57BMPR1B0.44465910
58PRKD20.44312414
59MAP3K10.44016709
60EIF2AK30.42955127
61PRKCG0.40889744
62MAP3K70.40565601
63MAP2K10.39536040
64MAP2K70.39040060
65LIMK10.37923694
66PAK30.37663885
67STK38L0.37210101
68IRAK10.32974214
69STK380.32889416
70RPS6KA20.32276981
71AKT30.31507717
72STK110.31233284
73IKBKE0.29055097
74ITK0.28851239
75MAP3K120.27692391
76TEC0.25958015
77TESK10.25061724
78CAMK2D0.22868305
79GRK10.22059689
80PDPK10.19512446
81LYN0.19393779
82PHKG20.19121170
83PHKG10.19121170
84PRKACB0.19000489
85ABL10.18886969
86CAMKK20.18582914
87PRKG10.18580358
88PDK10.16977299
89BCR0.15364685
90ERBB40.15339077
91CAMK2A0.14434134
92PRKAA10.13522672
93RPS6KB10.13237005
94PDK20.13053717
95PDGFRB0.11940953
96PRKACA0.11874863
97BRAF0.11198955
98IKBKB0.10774910
99MST40.10723092
100NEK60.10517361

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.96793748
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.24577244
3Protein export_Homo sapiens_hsa030603.04439146
4Collecting duct acid secretion_Homo sapiens_hsa049662.92754234
5Insulin secretion_Homo sapiens_hsa049112.71796521
6Butanoate metabolism_Homo sapiens_hsa006502.39887463
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35409676
8Ether lipid metabolism_Homo sapiens_hsa005652.04481755
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.03953187
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.97004031
11Type II diabetes mellitus_Homo sapiens_hsa049301.90264023
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85377062
13Vibrio cholerae infection_Homo sapiens_hsa051101.84980419
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83828161
15Ovarian steroidogenesis_Homo sapiens_hsa049131.83496524
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73960178
17Synaptic vesicle cycle_Homo sapiens_hsa047211.68047275
18Inositol phosphate metabolism_Homo sapiens_hsa005621.62294081
19Regulation of autophagy_Homo sapiens_hsa041401.53749812
20Taste transduction_Homo sapiens_hsa047421.32144372
21Dorso-ventral axis formation_Homo sapiens_hsa043201.29038882
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27089213
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20752070
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.17783819
25Type I diabetes mellitus_Homo sapiens_hsa049401.15895590
26Mineral absorption_Homo sapiens_hsa049781.13968320
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09481857
28mTOR signaling pathway_Homo sapiens_hsa041501.04297262
29Basal transcription factors_Homo sapiens_hsa030221.03023741
30Sulfur metabolism_Homo sapiens_hsa009201.01883568
31Renin secretion_Homo sapiens_hsa049241.00019513
32Adherens junction_Homo sapiens_hsa045200.96912600
33Insulin resistance_Homo sapiens_hsa049310.96540153
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95904645
35beta-Alanine metabolism_Homo sapiens_hsa004100.95870797
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94304147
37Circadian rhythm_Homo sapiens_hsa047100.94298664
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93859478
39Rheumatoid arthritis_Homo sapiens_hsa053230.93075485
40N-Glycan biosynthesis_Homo sapiens_hsa005100.92854524
41ABC transporters_Homo sapiens_hsa020100.91670800
42Prion diseases_Homo sapiens_hsa050200.90978427
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90192511
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89716759
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87522443
46FoxO signaling pathway_Homo sapiens_hsa040680.85506014
47Lysosome_Homo sapiens_hsa041420.85013594
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84866322
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78774110
50Salivary secretion_Homo sapiens_hsa049700.77787243
51Sphingolipid metabolism_Homo sapiens_hsa006000.76376870
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75635103
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72727593
54Propanoate metabolism_Homo sapiens_hsa006400.72485127
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71931530
56Fructose and mannose metabolism_Homo sapiens_hsa000510.69464423
57Phototransduction_Homo sapiens_hsa047440.69113672
58Lysine degradation_Homo sapiens_hsa003100.68517732
59Circadian entrainment_Homo sapiens_hsa047130.64128160
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63198830
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62602942
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62392014
63Prolactin signaling pathway_Homo sapiens_hsa049170.61096329
64Serotonergic synapse_Homo sapiens_hsa047260.61086008
65Insulin signaling pathway_Homo sapiens_hsa049100.60149211
66Glycerolipid metabolism_Homo sapiens_hsa005610.59766270
67Pancreatic secretion_Homo sapiens_hsa049720.59334664
68Tryptophan metabolism_Homo sapiens_hsa003800.58930101
69Peroxisome_Homo sapiens_hsa041460.55347534
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.54300425
71Nicotine addiction_Homo sapiens_hsa050330.54150857
72GABAergic synapse_Homo sapiens_hsa047270.49685991
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47999270
74AMPK signaling pathway_Homo sapiens_hsa041520.46811823
75Hedgehog signaling pathway_Homo sapiens_hsa043400.46718898
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.45214795
77Glutamatergic synapse_Homo sapiens_hsa047240.45017839
78Ras signaling pathway_Homo sapiens_hsa040140.43949281
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43451714
80Endometrial cancer_Homo sapiens_hsa052130.43381079
81Bile secretion_Homo sapiens_hsa049760.42682085
82cAMP signaling pathway_Homo sapiens_hsa040240.42558984
83PPAR signaling pathway_Homo sapiens_hsa033200.42284131
84Melanoma_Homo sapiens_hsa052180.41992840
85Thyroid hormone synthesis_Homo sapiens_hsa049180.40139331
86HIF-1 signaling pathway_Homo sapiens_hsa040660.39455800
87Olfactory transduction_Homo sapiens_hsa047400.38574901
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.37506147
89Rap1 signaling pathway_Homo sapiens_hsa040150.37125111
90Sulfur relay system_Homo sapiens_hsa041220.37101208
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36340091
92Long-term depression_Homo sapiens_hsa047300.32338315
93Wnt signaling pathway_Homo sapiens_hsa043100.31538438
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31456607
95Retinol metabolism_Homo sapiens_hsa008300.31285312
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28376131
97Cholinergic synapse_Homo sapiens_hsa047250.28085789
98Cardiac muscle contraction_Homo sapiens_hsa042600.26969929
99Metabolic pathways_Homo sapiens_hsa011000.26896310
100Tyrosine metabolism_Homo sapiens_hsa003500.24563554

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