HSF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.97029874
2piRNA metabolic process (GO:0034587)5.39255047
3presynaptic membrane organization (GO:0097090)5.23531492
4postsynaptic membrane organization (GO:0001941)5.11376806
5synapsis (GO:0007129)5.07707617
6resolution of meiotic recombination intermediates (GO:0000712)4.31972424
7pyrimidine nucleobase catabolic process (GO:0006208)4.21963890
8sympathetic nervous system development (GO:0048485)4.14349082
9regulation of timing of cell differentiation (GO:0048505)4.09469240
10regulation of development, heterochronic (GO:0040034)4.01004658
11short-term memory (GO:0007614)3.91953412
12chromosome organization involved in meiosis (GO:0070192)3.90070853
13limb bud formation (GO:0060174)3.87173729
14protein heterotetramerization (GO:0051290)3.79151426
15male meiosis I (GO:0007141)3.78446816
16DNA ligation (GO:0006266)3.78388588
17cerebral cortex radially oriented cell migration (GO:0021799)3.61199805
18male meiosis (GO:0007140)3.57784672
19negative regulation of execution phase of apoptosis (GO:1900118)3.56760139
20histone H2A acetylation (GO:0043968)3.56201602
21neuron cell-cell adhesion (GO:0007158)3.52123517
22DNA double-strand break processing (GO:0000729)3.41687512
23response to folic acid (GO:0051593)3.41076473
24meiotic chromosome segregation (GO:0045132)3.40202242
25GTP biosynthetic process (GO:0006183)3.38439356
26synaptonemal complex assembly (GO:0007130)3.36096692
27omega-hydroxylase P450 pathway (GO:0097267)3.29340095
28nonmotile primary cilium assembly (GO:0035058)3.24749293
29positive regulation of mitochondrial fission (GO:0090141)3.23031933
30nucleobase catabolic process (GO:0046113)3.21196122
31central nervous system myelination (GO:0022010)3.19942230
32axon ensheathment in central nervous system (GO:0032291)3.19942230
33reciprocal meiotic recombination (GO:0007131)3.18938137
34reciprocal DNA recombination (GO:0035825)3.18938137
35synaptonemal complex organization (GO:0070193)3.15593501
36generation of neurons (GO:0048699)3.13626092
37meiosis I (GO:0007127)3.12827684
38facial nerve structural organization (GO:0021612)3.09736913
39negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.08010343
40positive regulation of protein kinase C signaling (GO:0090037)3.07809889
41epithelial cilium movement (GO:0003351)3.06430976
42neural tube formation (GO:0001841)3.04536818
43proteasome assembly (GO:0043248)3.04020891
44negative regulation of keratinocyte proliferation (GO:0010839)3.03287848
45regulation of pigment cell differentiation (GO:0050932)3.00749164
46DNA synthesis involved in DNA repair (GO:0000731)2.99521692
47cullin deneddylation (GO:0010388)2.98902162
48negative regulation of DNA recombination (GO:0045910)2.98454642
49spinal cord association neuron differentiation (GO:0021527)2.98039729
50cranial nerve morphogenesis (GO:0021602)2.94337057
51protein neddylation (GO:0045116)2.93804270
52deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.89183821
53protein localization to chromosome (GO:0034502)2.87831072
54cilium movement (GO:0003341)2.86567330
55retina layer formation (GO:0010842)2.85792283
56meiotic nuclear division (GO:0007126)2.85756445
57photoreceptor cell maintenance (GO:0045494)2.85284130
58keratinocyte development (GO:0003334)2.84907761
59intraciliary transport (GO:0042073)2.84838227
60chromatin remodeling at centromere (GO:0031055)2.82948807
61protein localization to cilium (GO:0061512)2.82638093
62positive regulation of synapse assembly (GO:0051965)2.82581802
63positive regulation of amino acid transport (GO:0051957)2.81282563
64mesonephros development (GO:0001823)2.79533148
65axonal fasciculation (GO:0007413)2.78456162
66regulation of meiosis I (GO:0060631)2.77477171
67mesenchymal cell differentiation involved in renal system development (GO:2001012)2.75515598
68mesenchymal cell differentiation involved in kidney development (GO:0072161)2.75515598
69meiotic cell cycle process (GO:1903046)2.75023289
70GMP metabolic process (GO:0046037)2.73536758
71DNA integration (GO:0015074)2.73099825
72startle response (GO:0001964)2.72836435
73establishment of mitochondrion localization (GO:0051654)2.70572645
74centriole assembly (GO:0098534)2.69138141
75centriole replication (GO:0007099)2.68748625
76axoneme assembly (GO:0035082)2.68742333
77CENP-A containing nucleosome assembly (GO:0034080)2.68377828
78regulation of cilium movement (GO:0003352)2.68075495
79spermatid nucleus differentiation (GO:0007289)2.67287864
80microtubule depolymerization (GO:0007019)2.66471635
81axonemal dynein complex assembly (GO:0070286)2.63419150
82cornea development in camera-type eye (GO:0061303)2.63296490
83nucleoside diphosphate phosphorylation (GO:0006165)2.62886559
84interkinetic nuclear migration (GO:0022027)2.62463780
85protein deneddylation (GO:0000338)2.61755438
86regulation of DNA endoreduplication (GO:0032875)2.60304685
87DNA damage response, detection of DNA damage (GO:0042769)2.60162559
88somite development (GO:0061053)2.59385137
89long-chain fatty acid biosynthetic process (GO:0042759)2.58895996
90positive regulation of cellular amine metabolic process (GO:0033240)2.58340713
91ribonucleoprotein complex disassembly (GO:0032988)2.57994459
92microtubule anchoring (GO:0034453)2.57509517
93lymphoid progenitor cell differentiation (GO:0002320)2.56123034
94organelle disassembly (GO:1903008)2.55832922
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55338456
96gene silencing by RNA (GO:0031047)2.55052071
97regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.55040601
98UTP biosynthetic process (GO:0006228)2.54839701
99neuronal stem cell maintenance (GO:0097150)2.54399245
100mitotic sister chromatid cohesion (GO:0007064)2.54143290
101cranial nerve development (GO:0021545)2.53808783
102attachment of spindle microtubules to kinetochore (GO:0008608)2.53556862
103cranial nerve structural organization (GO:0021604)2.53529760
104regulation of mitotic spindle checkpoint (GO:1903504)2.53064819
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53064819
106negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51748674
107cell differentiation in spinal cord (GO:0021515)2.51686419
108kidney morphogenesis (GO:0060993)2.51565073
109retinal ganglion cell axon guidance (GO:0031290)2.50910741
110head development (GO:0060322)2.50653895
111DNA methylation involved in gamete generation (GO:0043046)2.50202359
112histone exchange (GO:0043486)2.49588154
113guanosine-containing compound biosynthetic process (GO:1901070)2.49110062
114neuron fate specification (GO:0048665)2.48663427
115regulation of activation of Janus kinase activity (GO:0010533)2.47804386
116sister chromatid cohesion (GO:0007062)2.47781104
117hippocampus development (GO:0021766)2.47486109
118response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.46318016
119ganglion development (GO:0061548)2.46284341
120spinal cord motor neuron differentiation (GO:0021522)2.44433285
121developmental pigmentation (GO:0048066)2.40865165
122regulation of memory T cell differentiation (GO:0043380)2.40513581
123regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40252186
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.39761053
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39761053
126mannosylation (GO:0097502)2.39561340
127transmission of nerve impulse (GO:0019226)2.39537116
128ubiquinone metabolic process (GO:0006743)2.39077534
129cell differentiation involved in kidney development (GO:0061005)2.38554210
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.38157589
131termination of RNA polymerase III transcription (GO:0006386)2.38157589
132cilium morphogenesis (GO:0060271)2.37740488
133isoprenoid biosynthetic process (GO:0008299)2.37608290
134regulation of respiratory system process (GO:0044065)2.37407539
135cilium assembly (GO:0042384)2.36366898
136neuron recognition (GO:0008038)2.35731407
137cell differentiation involved in metanephros development (GO:0072202)2.35175782
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.34063255
139righting reflex (GO:0060013)2.33131126
140gamma-aminobutyric acid transport (GO:0015812)2.31455244
141deoxyribose phosphate biosynthetic process (GO:0046385)2.30695097
1422-deoxyribonucleotide biosynthetic process (GO:0009265)2.30695097
143forebrain neuron differentiation (GO:0021879)2.30693148
144protein-cofactor linkage (GO:0018065)2.30527352
145regulation of rhodopsin mediated signaling pathway (GO:0022400)2.30099446
146regulation of synapse assembly (GO:0051963)2.30026713
147positive regulation of protein homodimerization activity (GO:0090073)2.29953580
148mitotic spindle checkpoint (GO:0071174)2.29876853
149protein K11-linked ubiquitination (GO:0070979)2.29034045
150melanin metabolic process (GO:0006582)2.28920597
151dendritic cell chemotaxis (GO:0002407)2.28795994
152negative regulation of astrocyte differentiation (GO:0048712)2.28702491
153membrane assembly (GO:0071709)2.28459785
154spindle checkpoint (GO:0031577)2.28063345
155eyelid development in camera-type eye (GO:0061029)2.26667521
156negative regulation of myoblast differentiation (GO:0045662)2.26522006
157ubiquinone biosynthetic process (GO:0006744)2.26119526
158spindle assembly checkpoint (GO:0071173)2.26059697
159kinetochore organization (GO:0051383)2.26010646
160eye photoreceptor cell differentiation (GO:0001754)2.25658817
161photoreceptor cell differentiation (GO:0046530)2.25658817
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.25620737
163NADH dehydrogenase complex assembly (GO:0010257)2.25620737
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.25620737
165behavioral response to nicotine (GO:0035095)2.25488180
166olfactory bulb development (GO:0021772)2.25453586
167cilium organization (GO:0044782)2.25401440
168neuronal action potential propagation (GO:0019227)2.25389376
169positive regulation of meiosis (GO:0045836)2.25339804
170mitotic spindle assembly checkpoint (GO:0007094)2.24203710
171Sertoli cell development (GO:0060009)2.24170408
172pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.23536767
173response to pheromone (GO:0019236)2.20925350
174negative regulation of mitotic sister chromatid separation (GO:2000816)2.20203014
175negative regulation of sister chromatid segregation (GO:0033046)2.20203014
176negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.20203014
177negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.20203014
178negative regulation of mitotic sister chromatid segregation (GO:0033048)2.20203014
179regulation of mRNA splicing, via spliceosome (GO:0048024)2.18945700
180regulation of double-strand break repair via homologous recombination (GO:0010569)2.18327607
181establishment of protein localization to mitochondrial membrane (GO:0090151)2.17214798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.60975065
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.53374649
3GBX2_23144817_ChIP-Seq_PC3_Human3.07013704
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.01752729
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88475520
6ZNF274_21170338_ChIP-Seq_K562_Hela2.85520675
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83944535
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79756067
9TAF15_26573619_Chip-Seq_HEK293_Human2.70803906
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.70728379
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69687404
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.68190099
13IGF1R_20145208_ChIP-Seq_DFB_Human2.66220916
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65631504
15* CBX2_27304074_Chip-Seq_ESCs_Mouse2.61886401
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.49823469
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32699903
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30127936
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28276318
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26341310
21* RNF2_27304074_Chip-Seq_NSC_Mouse2.24913612
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.21642745
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16601707
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15578988
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.13644316
26IRF1_19129219_ChIP-ChIP_H3396_Human2.12147063
27VDR_22108803_ChIP-Seq_LS180_Human2.11450750
28POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09890372
29SUZ12_27294783_Chip-Seq_NPCs_Mouse2.04694436
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04624847
31ELK1_19687146_ChIP-ChIP_HELA_Human2.01987001
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.96487387
33* P300_19829295_ChIP-Seq_ESCs_Human1.94088413
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.91569053
35FUS_26573619_Chip-Seq_HEK293_Human1.88993856
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85701729
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85643924
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85073745
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.84424842
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83257046
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.79561512
42* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77376545
43EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.74671503
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74501459
45* EZH2_27294783_Chip-Seq_NPCs_Mouse1.74274712
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74135560
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73540775
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.73391591
49P53_22387025_ChIP-Seq_ESCs_Mouse1.72779356
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71464273
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71329224
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71050664
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70452721
54P300_18555785_Chip-Seq_ESCs_Mouse1.67686639
55VDR_23849224_ChIP-Seq_CD4+_Human1.67550230
56ER_23166858_ChIP-Seq_MCF-7_Human1.67153848
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63626769
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.63504000
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.62687614
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61963482
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.61259497
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60829512
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.60291770
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59309905
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59217488
66RUNX1_27457419_Chip-Seq_LIVER_Mouse1.58046857
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50687440
68MYC_18940864_ChIP-ChIP_HL60_Human1.50215897
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.49768266
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47933845
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.47040128
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46517644
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.46383826
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.45666967
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.45401902
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42889954
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41530315
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41430352
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41195277
80EWS_26573619_Chip-Seq_HEK293_Human1.40748039
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.40308076
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.39916866
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38975031
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37721516
85KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37721516
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37721516
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36799360
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36799360
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36645151
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35831678
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35715608
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35237864
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35001665
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34844826
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34510296
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33755237
97PU1_27457419_Chip-Seq_LIVER_Mouse1.33416383
98ZFX_18555785_Chip-Seq_ESCs_Mouse1.33119898
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32092074
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.32005349
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30939029
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.30513028
103SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28170970
104* CRX_20693478_ChIP-Seq_RETINA_Mouse1.27905841
105ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26491187
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26169745
107FOXP3_21729870_ChIP-Seq_TREG_Human1.25851983
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25627145
109CBP_20019798_ChIP-Seq_JUKART_Human1.25627145
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.25491285
111AR_21572438_ChIP-Seq_LNCaP_Human1.25352499
112RNF2_27304074_Chip-Seq_ESCs_Mouse1.24872608
113SMAD4_21799915_ChIP-Seq_A2780_Human1.22152014
114DCP1A_22483619_ChIP-Seq_HELA_Human1.21110473
115* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20979060
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19504935
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19504935
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18021488
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16622186
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16519670
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14904011
122* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14889642
123GABP_19822575_ChIP-Seq_HepG2_Human1.14448723
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12921944
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.11336828
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11110097
127TTF2_22483619_ChIP-Seq_HELA_Human1.10968561
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10789601
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10549754
130SOX2_16153702_ChIP-ChIP_HESCs_Human1.10178350
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08307028
132* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06566259
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05923303
134TP53_22573176_ChIP-Seq_HFKS_Human1.05624594
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05525289
136TP53_18474530_ChIP-ChIP_U2OS_Human1.04425069
137* STAT3_23295773_ChIP-Seq_U87_Human1.03653408
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03065312
139* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02975722
140KDM2B_26808549_Chip-Seq_REH_Human1.02381165
141* RUNX2_22187159_ChIP-Seq_PCA_Human1.02329370
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02052118
143AR_25329375_ChIP-Seq_VCAP_Human1.01901609
144SOX9_26525672_Chip-Seq_HEART_Mouse1.01627301
145FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99347397
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99281689
147TCF4_23295773_ChIP-Seq_U87_Human0.99015825
148REST_21632747_ChIP-Seq_MESCs_Mouse0.96269294
149MYC_18555785_ChIP-Seq_MESCs_Mouse0.95588773
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94664414
151* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93917713
152HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92636489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.18086263
2MP0006292_abnormal_olfactory_placode4.04331943
3MP0001188_hyperpigmentation3.79228852
4MP0003880_abnormal_central_pattern3.66995473
5MP0009379_abnormal_foot_pigmentation3.20326587
6MP0000566_synostosis2.98787008
7MP0005409_darkened_coat_color2.95181896
8MP0002009_preneoplasia2.82383840
9MP0004381_abnormal_hair_follicle2.79080319
10MP0001529_abnormal_vocalization2.45588332
11MP0002277_abnormal_respiratory_mucosa2.26066898
12MP0002163_abnormal_gland_morphology2.19891035
13MP0000015_abnormal_ear_pigmentation2.18416335
14MP0006276_abnormal_autonomic_nervous2.15068247
15MP0008995_early_reproductive_senescence2.07172839
16MP0003121_genomic_imprinting2.04092698
17MP0003122_maternal_imprinting2.03919672
18MP0002102_abnormal_ear_morphology1.99505453
19MP0008789_abnormal_olfactory_epithelium1.98081080
20MP0002751_abnormal_autonomic_nervous1.96856784
21MP0003941_abnormal_skin_development1.87622050
22MP0003938_abnormal_ear_development1.87209268
23MP0000372_irregular_coat_pigmentation1.77905372
24MP0001346_abnormal_lacrimal_gland1.73019971
25MP0005645_abnormal_hypothalamus_physiol1.71371171
26MP0002638_abnormal_pupillary_reflex1.71284025
27MP0004145_abnormal_muscle_electrophysio1.68870722
28MP0000049_abnormal_middle_ear1.67829048
29MP0000778_abnormal_nervous_system1.67583095
30MP0002876_abnormal_thyroid_physiology1.65914408
31MP0005379_endocrine/exocrine_gland_phen1.63469110
32MP0001986_abnormal_taste_sensitivity1.63159498
33MP0005171_absent_coat_pigmentation1.62762327
34* MP0002210_abnormal_sex_determination1.62486956
35MP0005646_abnormal_pituitary_gland1.62251799
36MP0001984_abnormal_olfaction1.61687573
37MP0000026_abnormal_inner_ear1.61153542
38MP0004142_abnormal_muscle_tone1.56976025
39MP0002822_catalepsy1.55498877
40MP0003315_abnormal_perineum_morphology1.54626453
41MP0000631_abnormal_neuroendocrine_gland1.53450081
42MP0010094_abnormal_chromosome_stability1.52130238
43MP0004742_abnormal_vestibular_system1.51099601
44MP0002177_abnormal_outer_ear1.50705773
45MP0005394_taste/olfaction_phenotype1.47588886
46MP0005499_abnormal_olfactory_system1.47588886
47MP0005174_abnormal_tail_pigmentation1.42312183
48* MP0001929_abnormal_gametogenesis1.42027191
49MP0003890_abnormal_embryonic-extraembry1.39295901
50MP0003567_abnormal_fetal_cardiomyocyte1.38318280
51MP0005423_abnormal_somatic_nervous1.38186113
52MP0005187_abnormal_penis_morphology1.36523398
53MP0002234_abnormal_pharynx_morphology1.35922477
54MP0006035_abnormal_mitochondrial_morpho1.35374702
55MP0008057_abnormal_DNA_replication1.32737837
56* MP0003698_abnormal_male_reproductive1.30996701
57MP0008260_abnormal_autophagy1.30716191
58* MP0001145_abnormal_male_reproductive1.27888225
59MP0003937_abnormal_limbs/digits/tail_de1.27691681
60MP0002184_abnormal_innervation1.26839445
61* MP0000653_abnormal_sex_gland1.25845317
62MP0002837_dystrophic_cardiac_calcinosis1.24524908
63MP0002735_abnormal_chemical_nociception1.24424207
64MP0002249_abnormal_larynx_morphology1.23763937
65MP0001299_abnormal_eye_distance/1.22855978
66MP0004859_abnormal_synaptic_plasticity1.22788121
67MP0003646_muscle_fatigue1.20305325
68MP0001293_anophthalmia1.20219980
69MP0006072_abnormal_retinal_apoptosis1.19581927
70MP0002938_white_spotting1.18831948
71MP0001348_abnormal_lacrimal_gland1.18684478
72MP0003635_abnormal_synaptic_transmissio1.18628096
73MP0003787_abnormal_imprinting1.17996208
74MP0001485_abnormal_pinna_reflex1.17412331
75MP0002095_abnormal_skin_pigmentation1.17215513
76MP0002752_abnormal_somatic_nervous1.16912332
77MP0000569_abnormal_digit_pigmentation1.16290818
78MP0001486_abnormal_startle_reflex1.15747942
79MP0009250_abnormal_appendicular_skeleto1.15544329
80MP0002653_abnormal_ependyma_morphology1.15390167
81MP0005551_abnormal_eye_electrophysiolog1.15265789
82MP0001963_abnormal_hearing_physiology1.15101370
83MP0005075_abnormal_melanosome_morpholog1.14153711
84MP0004215_abnormal_myocardial_fiber1.13765045
85MP0003693_abnormal_embryo_hatching1.13097330
86MP0003221_abnormal_cardiomyocyte_apopto1.12099050
87MP0000751_myopathy1.11899962
88MP0009697_abnormal_copulation1.11762921
89MP0004811_abnormal_neuron_physiology1.10376668
90MP0002736_abnormal_nociception_after1.09660539
91MP0008058_abnormal_DNA_repair1.08200558
92MP0004924_abnormal_behavior1.07611273
93MP0005386_behavior/neurological_phenoty1.07611273
94MP0003119_abnormal_digestive_system1.07158658
95MP0002063_abnormal_learning/memory/cond1.06983094
96MP0001919_abnormal_reproductive_system1.05250673
97MP0002067_abnormal_sensory_capabilities1.03569909
98MP0004147_increased_porphyrin_level1.03469012
99MP0005253_abnormal_eye_physiology1.02463610
100MP0001286_abnormal_eye_development1.01802276
101MP0003123_paternal_imprinting1.00800901
102MP0004133_heterotaxia1.00439442
103MP0002572_abnormal_emotion/affect_behav1.00000689
104MP0005408_hypopigmentation0.99228727
105MP0002160_abnormal_reproductive_system0.98617091
106MP0001968_abnormal_touch/_nociception0.98074209
107MP0003385_abnormal_body_wall0.96569097
108MP0002557_abnormal_social/conspecific_i0.96172396
109MP0000681_abnormal_thyroid_gland0.96089272
110MP0006036_abnormal_mitochondrial_physio0.92940792
111* MP0002152_abnormal_brain_morphology0.91459756
112MP0005391_vision/eye_phenotype0.90688848
113MP0003755_abnormal_palate_morphology0.88575689
114MP0003111_abnormal_nucleus_morphology0.88171665
115MP0009046_muscle_twitch0.88104691
116MP0003011_delayed_dark_adaptation0.87939790
117MP0004270_analgesia0.87047405
118MP0002233_abnormal_nose_morphology0.86993209
119MP0002272_abnormal_nervous_system0.83562694
120MP0001502_abnormal_circadian_rhythm0.83425288
121MP0005389_reproductive_system_phenotype0.82384948
122MP0003786_premature_aging0.82050475
123MP0002064_seizures0.81842262
124MP0004782_abnormal_surfactant_physiolog0.81528474
125MP0009745_abnormal_behavioral_response0.80992902
126MP0003137_abnormal_impulse_conducting0.80941991
127MP0002882_abnormal_neuron_morphology0.80218139
128MP0005084_abnormal_gallbladder_morpholo0.79634678
129MP0002148_abnormal_hypersensitivity_rea0.78984877
130MP0005195_abnormal_posterior_eye0.78261862
131MP0001340_abnormal_eyelid_morphology0.78192380
132MP0001905_abnormal_dopamine_level0.75872803
133MP0005410_abnormal_fertilization0.75663048
134MP0002734_abnormal_mechanical_nocicepti0.75146492
135MP0000613_abnormal_salivary_gland0.73724453
136MP0008877_abnormal_DNA_methylation0.71242877
137MP0005248_abnormal_Harderian_gland0.71210683
138MP0002138_abnormal_hepatobiliary_system0.70998178
139MP0005257_abnormal_intraocular_pressure0.68506529
140MP0000516_abnormal_urinary_system0.68443711
141MP0005367_renal/urinary_system_phenotyp0.68443711
142MP0000647_abnormal_sebaceous_gland0.68435522
143MP0003861_abnormal_nervous_system0.67863172
144MP0001177_atelectasis0.67128974
145MP0000955_abnormal_spinal_cord0.66874027
146MP0008932_abnormal_embryonic_tissue0.65595914

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)3.44544365
2Septo-optic dysplasia (HP:0100842)3.40881645
3Parakeratosis (HP:0001036)3.32562181
4Shoulder girdle muscle weakness (HP:0003547)3.29695315
5Optic nerve hypoplasia (HP:0000609)3.27361282
6Volvulus (HP:0002580)3.25471674
7Abnormal ciliary motility (HP:0012262)3.20257254
8Abnormality of the labia minora (HP:0012880)3.13917352
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.10952217
10Rimmed vacuoles (HP:0003805)3.08718735
11Absent/shortened dynein arms (HP:0200106)3.07199735
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.07199735
13Abnormality of secondary sexual hair (HP:0009888)2.99626894
14Abnormality of the axillary hair (HP:0100134)2.99626894
15Supernumerary spleens (HP:0009799)2.86956230
16Abnormality of the septum pellucidum (HP:0007375)2.84460176
17Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.83585314
18Absent septum pellucidum (HP:0001331)2.83368540
19Abnormal respiratory motile cilium physiology (HP:0012261)2.77890801
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77784792
21Drooling (HP:0002307)2.74247999
22Abnormal respiratory epithelium morphology (HP:0012253)2.73647085
23Abnormal respiratory motile cilium morphology (HP:0005938)2.73647085
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73388399
25Type I transferrin isoform profile (HP:0003642)2.66870855
26Medial flaring of the eyebrow (HP:0010747)2.65795177
27Oligodactyly (hands) (HP:0001180)2.62570138
28Molar tooth sign on MRI (HP:0002419)2.59596954
29Abnormality of midbrain morphology (HP:0002418)2.59596954
30True hermaphroditism (HP:0010459)2.51311990
31Colon cancer (HP:0003003)2.49360940
32Retinal dysplasia (HP:0007973)2.48120869
33Excessive salivation (HP:0003781)2.46144650
34Cortical dysplasia (HP:0002539)2.44963517
35Chromsome breakage (HP:0040012)2.39352756
36Gonadotropin excess (HP:0000837)2.38951335
37Optic disc pallor (HP:0000543)2.38297271
38Abnormality of the hip-girdle musculature (HP:0001445)2.33734228
39Abnormality of the musculature of the pelvis (HP:0001469)2.33734228
40Intestinal atresia (HP:0011100)2.32977800
41Osteomalacia (HP:0002749)2.32810146
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30550815
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.30550815
44Poor coordination (HP:0002370)2.30356246
45Attenuation of retinal blood vessels (HP:0007843)2.28997566
46Lissencephaly (HP:0001339)2.28873561
47Amyotrophic lateral sclerosis (HP:0007354)2.27442067
48Gait imbalance (HP:0002141)2.26721782
49Sex reversal (HP:0012245)2.26501840
50Abnormal sex determination (HP:0012244)2.26501840
513-Methylglutaconic aciduria (HP:0003535)2.25254481
52Type II lissencephaly (HP:0007260)2.22311755
53Congenital primary aphakia (HP:0007707)2.22292178
54Chronic hepatic failure (HP:0100626)2.21719381
55Preaxial hand polydactyly (HP:0001177)2.21665656
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21111808
57Ulnar claw (HP:0001178)2.16730104
58Nephrogenic diabetes insipidus (HP:0009806)2.16485416
59Hypoplasia of the fovea (HP:0007750)2.15613462
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.15613462
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15125047
62Pancreatic cysts (HP:0001737)2.13637826
63Pancreatic fibrosis (HP:0100732)2.12527482
64Anhidrosis (HP:0000970)2.11248320
65Nonprogressive disorder (HP:0003680)2.10406463
66Atrophy/Degeneration involving motor neurons (HP:0007373)2.09530695
67Abnormality of the corticospinal tract (HP:0002492)2.07260879
68Male pseudohermaphroditism (HP:0000037)2.06809565
69Increased IgM level (HP:0003496)2.02363051
70Abnormality of the renal medulla (HP:0100957)2.01347818
71Pelvic girdle muscle weakness (HP:0003749)2.00269571
72Oligodactyly (HP:0012165)2.00133654
73Thyroid-stimulating hormone excess (HP:0002925)1.99528433
74Genital tract atresia (HP:0001827)1.99477101
75Vaginal atresia (HP:0000148)1.98783470
76Renal Fanconi syndrome (HP:0001994)1.98517546
77Amelogenesis imperfecta (HP:0000705)1.98423108
78Median cleft lip (HP:0000161)1.97226249
79Decreased central vision (HP:0007663)1.97202499
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.95897941
81Methylmalonic acidemia (HP:0002912)1.95527003
82Abnormal lung lobation (HP:0002101)1.95447759
83Urinary urgency (HP:0000012)1.95186945
84Aplasia/Hypoplasia of the lens (HP:0008063)1.94874177
85Occipital encephalocele (HP:0002085)1.93680295
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93513101
87Aplasia cutis congenita (HP:0001057)1.92486451
88Anomalous pulmonary venous return (HP:0010772)1.91120694
89Abnormality of the metopic suture (HP:0005556)1.90554334
90Postaxial hand polydactyly (HP:0001162)1.90411529
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89722809
92Adrenal hypoplasia (HP:0000835)1.88912863
93Concave nail (HP:0001598)1.88622014
94Tubulointerstitial nephritis (HP:0001970)1.88619602
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88285265
96Abnormality of alanine metabolism (HP:0010916)1.88285265
97Hyperalaninemia (HP:0003348)1.88285265
98Anencephaly (HP:0002323)1.88145281
99Hepatoblastoma (HP:0002884)1.88058130
100Acute necrotizing encephalopathy (HP:0006965)1.86851930
101Cutaneous finger syndactyly (HP:0010554)1.86689390
102Abnormality of the lacrimal duct (HP:0011481)1.86478920
103Specific learning disability (HP:0001328)1.85892120
104Congenital sensorineural hearing impairment (HP:0008527)1.85655776
105Patchy hypopigmentation of hair (HP:0011365)1.85221088
106Febrile seizures (HP:0002373)1.84676733
107Abnormality of the lower motor neuron (HP:0002366)1.84491240
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.82849115
109Lip pit (HP:0100267)1.82413010
110Reduced antithrombin III activity (HP:0001976)1.81697096
111Abnormality of the nasolacrimal system (HP:0000614)1.81181326
112Broad-based gait (HP:0002136)1.80483410
113Narrow forehead (HP:0000341)1.80247994
114Postaxial foot polydactyly (HP:0001830)1.79925418
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.79680366
116Exercise-induced muscle cramps (HP:0003710)1.79367913
117Nephroblastoma (Wilms tumor) (HP:0002667)1.79231432
118Abnormal hair whorl (HP:0010721)1.78786604
119Popliteal pterygium (HP:0009756)1.78392594
120Split foot (HP:0001839)1.78127057
121Absent speech (HP:0001344)1.77701322
122Nasolacrimal duct obstruction (HP:0000579)1.77449821
123Aplasia/hypoplasia of the uterus (HP:0008684)1.76977618
124Medulloblastoma (HP:0002885)1.76888547
125Hypoplastic heart (HP:0001961)1.76863485
126Hypoplastic left heart (HP:0004383)1.75664135
127Broad foot (HP:0001769)1.75232173
128Nephronophthisis (HP:0000090)1.74996668
129Dry hair (HP:0011359)1.74618785
130White forelock (HP:0002211)1.74552139
131Short tibia (HP:0005736)1.74180219
132Cupped ear (HP:0000378)1.73955574
133Aganglionic megacolon (HP:0002251)1.73927557
134Triphalangeal thumb (HP:0001199)1.73916219
135Abnormality of the ileum (HP:0001549)1.72461521
136Multicystic kidney dysplasia (HP:0000003)1.71941465
137Anophthalmia (HP:0000528)1.71097819
138Embryonal renal neoplasm (HP:0011794)1.70725942
139Conical tooth (HP:0000698)1.70570241
140Hyperglycinemia (HP:0002154)1.70254678
141Congenital ichthyosiform erythroderma (HP:0007431)1.69610360
142Pachygyria (HP:0001302)1.69504838
143Decreased testicular size (HP:0008734)1.69479787
144Abnormality of incisor morphology (HP:0011063)1.69236842
145Increased CSF lactate (HP:0002490)1.68862456
146Meckel diverticulum (HP:0002245)1.68687748
147Increased hepatocellular lipid droplets (HP:0006565)1.68529970
148Abnormality of the pulmonary veins (HP:0011718)1.68206625
149Midline defect of the nose (HP:0004122)1.67740356
150Abnormality of the renal cortex (HP:0011035)1.67519961
151Sclerocornea (HP:0000647)1.67385610
152Abnormality of the fovea (HP:0000493)1.67212375
153Renal dysplasia (HP:0000110)1.66994728
154Astigmatism (HP:0000483)1.66724063
155Duplicated collecting system (HP:0000081)1.66646014
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.66516972
157Papillary thyroid carcinoma (HP:0002895)1.66264126
158Abnormality of the phalanges of the hallux (HP:0010057)1.65916818
159Impaired vibration sensation in the lower limbs (HP:0002166)1.65688544
160Progressive macrocephaly (HP:0004481)1.65615229
161Abnormal mitochondria in muscle tissue (HP:0008316)1.64562532
162Sloping forehead (HP:0000340)1.64366297
163Micropenis (HP:0000054)1.64193810
164Hyperventilation (HP:0002883)1.64156841
165Cerebellar dysplasia (HP:0007033)1.62139890
166Progressive inability to walk (HP:0002505)1.61695563
167Acute encephalopathy (HP:0006846)1.61523875
168Abnormality of chromosome stability (HP:0003220)1.59458940
169Short foot (HP:0001773)1.59426921
170Prominent nasal bridge (HP:0000426)1.59403730
171Duodenal stenosis (HP:0100867)1.58919520
172Small intestinal stenosis (HP:0012848)1.58919520
173Polyphagia (HP:0002591)1.58165109
174Inability to walk (HP:0002540)1.57982086
175Gastrointestinal atresia (HP:0002589)1.57959056
176Failure to thrive in infancy (HP:0001531)1.57844580
177Ependymoma (HP:0002888)1.57349569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.51454148
2MKNK23.48272934
3MAP3K43.23300117
4TRIM283.06666293
5SRPK12.59930375
6TNIK2.51853352
7WNK32.49956991
8YES12.49341714
9MKNK12.45613848
10MUSK2.42413477
11EPHA42.25526464
12PRPF4B2.12333088
13CDK192.05918430
14MAP4K22.04599020
15TLK11.94757835
16STK161.89330320
17BMPR1B1.84538344
18CSNK1G21.78541451
19AKT31.73507973
20BCR1.69762169
21MAP2K71.67998278
22EIF2AK21.66948856
23MAP3K141.64748232
24IRAK41.61488251
25WEE11.53754203
26GRK71.51768576
27MAPK131.51669341
28PBK1.49620028
29ZAK1.48188701
30BMPR21.45216034
31IRAK21.41279130
32FRK1.39652034
33DYRK21.38126374
34IRAK31.36812669
35VRK11.36811324
36NEK11.34426189
37MAPK151.33272567
38IRAK11.31836170
39ADRBK21.31556236
40EIF2AK31.21311912
41PDK21.20906481
42BUB11.19484490
43MINK11.19243351
44MAP2K41.18809708
45CCNB11.18622126
46PKN11.15032958
47RPS6KA41.14592127
48NLK1.12193023
49BLK1.10993210
50MARK11.07713999
51SGK21.06949800
52STK391.06298165
53MST41.03249166
54CDC71.03039856
55PLK11.01798639
56STK241.00823095
57TTK0.98714840
58ERBB30.96556756
59INSRR0.95437717
60PRKD20.95282835
61CDK30.93124398
62PNCK0.92786796
63BRSK20.92401842
64SGK2230.87832991
65SGK4940.87832991
66TXK0.84534397
67NUAK10.84464785
68STK38L0.84315220
69PAK30.83346945
70NEK60.82743404
71BRAF0.82010091
72PRKCG0.81162808
73PLK40.77825445
74GRK10.77776431
75CLK10.77713567
76NME10.76847337
77ATR0.75722107
78KSR10.75502308
79FGR0.73996064
80PLK30.72958933
81UHMK10.72521683
82ATM0.72085123
83TAF10.71903995
84PHKG10.70599719
85PHKG20.70599719
86DYRK1B0.66981806
87LIMK10.65350123
88BCKDK0.64310040
89ACVR1B0.62216772
90CDK140.61089218
91CSNK1E0.60978477
92CAMK2B0.60667526
93OXSR10.60413942
94PRKCE0.59996838
95RPS6KA50.59993662
96IKBKB0.58068994
97PLK20.56555333
98CSNK1G10.55151990
99CDK180.55017140
100OBSCN0.54295803
101DYRK1A0.52961470
102WNK10.52790769
103BRSK10.51992679
104NTRK30.51866367
105CAMKK20.51219544
106PINK10.50795839
107EIF2AK10.50686892
108CAMK40.50268175
109TNK20.49628962
110CHEK10.48656598
111CSNK1G30.47966562
112CDK50.47687686
113CHEK20.47071177
114CDK11A0.46553138
115CDK150.45381796
116ADRBK10.44807760
117LATS10.44635303
118CAMK2A0.44517149
119BRD40.42182079
120AURKA0.41330383
121PIM20.41085845
122PRKACB0.39749618
123CSNK1D0.38968673
124CSNK1A1L0.38779478
125CDK20.38680638
126CDK80.38524934
127CDK10.38356066
128PASK0.38310014
129EPHA30.38121192
130SIK30.37837356
131PRKDC0.37409898
132CHUK0.36637027
133PIK3CG0.35752985
134DYRK30.34296740
135CSNK2A10.34196066
136PRKG10.33337987
137ERBB40.32259151
138EPHB20.31525584
139CAMK2D0.31281377
140FES0.30203993
141HIPK20.29870797
142TSSK60.29332343
143PRKACA0.29298701
144IKBKE0.27396716
145CAMK2G0.26809634
146PRKAA20.25810004
147NTRK20.25797969

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.87955301
2Fanconi anemia pathway_Homo sapiens_hsa034602.41967090
3Allograft rejection_Homo sapiens_hsa053302.33681367
4Protein export_Homo sapiens_hsa030602.30758564
5Autoimmune thyroid disease_Homo sapiens_hsa053202.30517591
6Propanoate metabolism_Homo sapiens_hsa006402.19916359
7Graft-versus-host disease_Homo sapiens_hsa053322.15726139
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13997408
9Ribosome_Homo sapiens_hsa030102.09831331
10Basal transcription factors_Homo sapiens_hsa030222.05315848
11Steroid biosynthesis_Homo sapiens_hsa001002.04904261
12Oxidative phosphorylation_Homo sapiens_hsa001902.03274672
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02001165
14Ether lipid metabolism_Homo sapiens_hsa005651.96374613
15RNA transport_Homo sapiens_hsa030131.95142711
16RNA polymerase_Homo sapiens_hsa030201.90997437
17Homologous recombination_Homo sapiens_hsa034401.90424408
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86795604
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82889804
20Proteasome_Homo sapiens_hsa030501.79197478
21Nicotine addiction_Homo sapiens_hsa050331.71792288
22Circadian rhythm_Homo sapiens_hsa047101.65324241
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63337597
24Arachidonic acid metabolism_Homo sapiens_hsa005901.60915057
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58725332
26Butanoate metabolism_Homo sapiens_hsa006501.57114485
27Oocyte meiosis_Homo sapiens_hsa041141.56688785
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56143889
29Fatty acid elongation_Homo sapiens_hsa000621.55431167
30Non-homologous end-joining_Homo sapiens_hsa034501.54120677
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50546328
32mRNA surveillance pathway_Homo sapiens_hsa030151.49308982
33Cell cycle_Homo sapiens_hsa041101.48930020
34Sphingolipid metabolism_Homo sapiens_hsa006001.46307747
35Parkinsons disease_Homo sapiens_hsa050121.46106515
36Huntingtons disease_Homo sapiens_hsa050161.45951666
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43751197
38Spliceosome_Homo sapiens_hsa030401.36924577
39Serotonergic synapse_Homo sapiens_hsa047261.36695808
40Selenocompound metabolism_Homo sapiens_hsa004501.35032247
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.31641263
42Axon guidance_Homo sapiens_hsa043601.29951420
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26555724
44Linoleic acid metabolism_Homo sapiens_hsa005911.21149044
45Pyruvate metabolism_Homo sapiens_hsa006201.18510881
46Nucleotide excision repair_Homo sapiens_hsa034201.16001895
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14386396
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14252406
49Alzheimers disease_Homo sapiens_hsa050101.14062291
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11601342
51Taste transduction_Homo sapiens_hsa047421.11191758
52One carbon pool by folate_Homo sapiens_hsa006701.10672693
53Pyrimidine metabolism_Homo sapiens_hsa002401.10008467
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09365085
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.06857719
56Type I diabetes mellitus_Homo sapiens_hsa049401.05555301
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05394025
58Asthma_Homo sapiens_hsa053101.03428229
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02690032
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.02689348
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01345241
62Collecting duct acid secretion_Homo sapiens_hsa049660.97640011
63Basal cell carcinoma_Homo sapiens_hsa052170.95662494
64Dopaminergic synapse_Homo sapiens_hsa047280.94079551
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93068560
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.92244285
67Purine metabolism_Homo sapiens_hsa002300.90274150
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.88928688
69Mismatch repair_Homo sapiens_hsa034300.88864933
70Wnt signaling pathway_Homo sapiens_hsa043100.88080778
71beta-Alanine metabolism_Homo sapiens_hsa004100.86569276
72Synaptic vesicle cycle_Homo sapiens_hsa047210.85982835
73Measles_Homo sapiens_hsa051620.84459138
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83813192
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83446589
76Peroxisome_Homo sapiens_hsa041460.83181401
77Retinol metabolism_Homo sapiens_hsa008300.82921373
78RNA degradation_Homo sapiens_hsa030180.82036600
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80756251
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80006642
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79451349
82Rheumatoid arthritis_Homo sapiens_hsa053230.78750067
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77956932
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77750572
85DNA replication_Homo sapiens_hsa030300.77545110
86Morphine addiction_Homo sapiens_hsa050320.77369038
87Circadian entrainment_Homo sapiens_hsa047130.76180160
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75250741
89Hedgehog signaling pathway_Homo sapiens_hsa043400.74778539
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73826579
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70807962
92Cocaine addiction_Homo sapiens_hsa050300.68339259
93Hippo signaling pathway_Homo sapiens_hsa043900.67223549
94Glutamatergic synapse_Homo sapiens_hsa047240.66578482
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66533566
96Systemic lupus erythematosus_Homo sapiens_hsa053220.65022117
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63876022
98Fatty acid metabolism_Homo sapiens_hsa012120.61411242
99Carbon metabolism_Homo sapiens_hsa012000.60448072
100Arginine and proline metabolism_Homo sapiens_hsa003300.60312689
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60201347
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59627585
103Amphetamine addiction_Homo sapiens_hsa050310.57282689
104Prostate cancer_Homo sapiens_hsa052150.56133843
105Herpes simplex infection_Homo sapiens_hsa051680.55150369
106p53 signaling pathway_Homo sapiens_hsa041150.54017685
107Base excision repair_Homo sapiens_hsa034100.53087846
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52980719
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51573616
110Regulation of autophagy_Homo sapiens_hsa041400.49244446
111GABAergic synapse_Homo sapiens_hsa047270.48788004
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48765434
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48409307
114Cardiac muscle contraction_Homo sapiens_hsa042600.47888561
115Melanoma_Homo sapiens_hsa052180.47664575
116Histidine metabolism_Homo sapiens_hsa003400.47187620
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46668759
118Epstein-Barr virus infection_Homo sapiens_hsa051690.46411603
119TGF-beta signaling pathway_Homo sapiens_hsa043500.46093919
120Long-term depression_Homo sapiens_hsa047300.45129566
121Alcoholism_Homo sapiens_hsa050340.43445715
122Lysine degradation_Homo sapiens_hsa003100.43145335
123Olfactory transduction_Homo sapiens_hsa047400.41623134
124Tryptophan metabolism_Homo sapiens_hsa003800.40683285
125Insulin secretion_Homo sapiens_hsa049110.40668489
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40262015
127Metabolic pathways_Homo sapiens_hsa011000.39335125
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39040294
129Melanogenesis_Homo sapiens_hsa049160.38580173
130Sulfur relay system_Homo sapiens_hsa041220.38564132
131Biosynthesis of amino acids_Homo sapiens_hsa012300.38373276
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37855018
133Sulfur metabolism_Homo sapiens_hsa009200.37507617
134Ras signaling pathway_Homo sapiens_hsa040140.35894197
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35054990
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.34661988
137Other glycan degradation_Homo sapiens_hsa005110.34566453
138Folate biosynthesis_Homo sapiens_hsa007900.33490877
139Tyrosine metabolism_Homo sapiens_hsa003500.33217655
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33010619
141AMPK signaling pathway_Homo sapiens_hsa041520.32789398
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31739413
143Prion diseases_Homo sapiens_hsa050200.26948984
144ErbB signaling pathway_Homo sapiens_hsa040120.24790606
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24663275

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