HSF2BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)9.84851089
2regulation of female gonad development (GO:2000194)8.09215362
3multicellular organism reproduction (GO:0032504)5.94861520
4synapsis (GO:0007129)5.88139617
5oocyte development (GO:0048599)5.63547224
6regulation of acrosome reaction (GO:0060046)5.60617518
7retinal cone cell development (GO:0046549)5.42893562
8glycine transport (GO:0015816)5.33919683
9piRNA metabolic process (GO:0034587)5.13446866
10positive regulation of histone H3-K4 methylation (GO:0051571)5.04683746
11mitotic metaphase plate congression (GO:0007080)5.01377414
12protein K6-linked ubiquitination (GO:0085020)5.00352743
13gene silencing by RNA (GO:0031047)4.99509320
14regulation of cell maturation (GO:1903429)4.85203347
15centriole replication (GO:0007099)4.84604890
16male meiosis I (GO:0007141)4.73045869
17positive regulation of mitotic sister chromatid separation (GO:1901970)4.71797406
18positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.71797406
19positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.71797406
20regulation of steroid hormone secretion (GO:2000831)4.62766467
21DNA replication initiation (GO:0006270)4.45750630
22meiotic chromosome segregation (GO:0045132)4.42028756
23regulation of posttranscriptional gene silencing (GO:0060147)4.36975240
24regulation of gene silencing by miRNA (GO:0060964)4.36975240
25regulation of gene silencing by RNA (GO:0060966)4.36975240
26metaphase plate congression (GO:0051310)4.34299061
27nuclear pore organization (GO:0006999)4.31816386
28DNA replication-dependent nucleosome organization (GO:0034723)4.28368882
29DNA replication-dependent nucleosome assembly (GO:0006335)4.28368882
30regulation of meiosis (GO:0040020)4.27376939
31negative regulation of reproductive process (GO:2000242)4.19808335
32nuclear pore complex assembly (GO:0051292)4.14972108
33DNA replication checkpoint (GO:0000076)4.13444078
34chromatin remodeling at centromere (GO:0031055)4.12144414
35oogenesis (GO:0048477)4.10680607
36reproduction (GO:0000003)4.07717979
37positive regulation of gastrulation (GO:2000543)4.05989545
38regulation of meiosis I (GO:0060631)4.01558216
39regulation of helicase activity (GO:0051095)4.00822867
40binding of sperm to zona pellucida (GO:0007339)4.00526890
41establishment of chromosome localization (GO:0051303)3.95786862
42meiosis I (GO:0007127)3.95204180
43mitotic sister chromatid segregation (GO:0000070)3.95045465
44protein localization to kinetochore (GO:0034501)3.90296994
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.89643540
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.89643540
47attachment of spindle microtubules to kinetochore (GO:0008608)3.89571537
48kinetochore assembly (GO:0051382)3.88926762
49mitotic nuclear envelope disassembly (GO:0007077)3.88319480
50kinetochore organization (GO:0051383)3.88318865
51CENP-A containing nucleosome assembly (GO:0034080)3.86815285
52DNA methylation involved in gamete generation (GO:0043046)3.86303326
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.81314762
54histone exchange (GO:0043486)3.76809375
55male meiosis (GO:0007140)3.76705634
56fertilization (GO:0009566)3.76584938
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74096161
58chromosome condensation (GO:0030261)3.73203763
59synaptonemal complex assembly (GO:0007130)3.73009962
60protein localization to chromosome, centromeric region (GO:0071459)3.72911522
61translesion synthesis (GO:0019985)3.72699157
62DNA strand elongation involved in DNA replication (GO:0006271)3.71325251
63mitotic chromosome condensation (GO:0007076)3.66616848
64regulation of meiotic cell cycle (GO:0051445)3.64478062
65centriole assembly (GO:0098534)3.62450973
66regulation of spindle checkpoint (GO:0090231)3.58855214
67membrane disassembly (GO:0030397)3.58821633
68nuclear envelope disassembly (GO:0051081)3.58821633
69regulation of telomere maintenance via telomerase (GO:0032210)3.57346411
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.56815250
71reciprocal meiotic recombination (GO:0007131)3.56747137
72reciprocal DNA recombination (GO:0035825)3.56747137
73sperm-egg recognition (GO:0035036)3.55059111
74DNA replication-independent nucleosome assembly (GO:0006336)3.53056572
75DNA replication-independent nucleosome organization (GO:0034724)3.53056572
76negative regulation of meiosis (GO:0045835)3.53030283
77telomere maintenance via semi-conservative replication (GO:0032201)3.52368332
78DNA strand elongation (GO:0022616)3.52009975
79maturation of 5.8S rRNA (GO:0000460)3.51177589
80regulation of centriole replication (GO:0046599)3.50751962
81spermatid nucleus differentiation (GO:0007289)3.50254368
82L-amino acid import (GO:0043092)3.48688350
83ribosome assembly (GO:0042255)3.47401949
84protein kinase C signaling (GO:0070528)3.45417475
85mismatch repair (GO:0006298)3.44306454
86nucleus organization (GO:0006997)3.44186142
87meiotic nuclear division (GO:0007126)3.44103027
88nucleobase biosynthetic process (GO:0046112)3.42284779
89synaptonemal complex organization (GO:0070193)3.41061770
90regulation of histone H3-K9 methylation (GO:0051570)3.39939205
91microtubule depolymerization (GO:0007019)3.38653578
92regulation of chromosome segregation (GO:0051983)3.38340413
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.38224025
94purine nucleobase biosynthetic process (GO:0009113)3.37776590
95regulation of centrosome cycle (GO:0046605)3.36392871
96single fertilization (GO:0007338)3.36011074
97folic acid-containing compound biosynthetic process (GO:0009396)3.35394742
98chromosome organization involved in meiosis (GO:0070192)3.33658770
99telomere maintenance via recombination (GO:0000722)3.32762500
100DNA packaging (GO:0006323)3.32720242
101negative regulation of chromosome segregation (GO:0051985)3.31782896
102gene silencing (GO:0016458)3.30436319
103regulation of spindle organization (GO:0090224)3.30083603
104IMP biosynthetic process (GO:0006188)3.28426489
105spindle checkpoint (GO:0031577)3.27822770
106DNA alkylation (GO:0006305)3.27229227
107DNA methylation (GO:0006306)3.27229227
108meiotic cell cycle process (GO:1903046)3.27036555
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25800487
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25046373
111ribosome biogenesis (GO:0042254)3.24877788
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24778592
113positive regulation of chromosome segregation (GO:0051984)3.24545003
114positive regulation of histone methylation (GO:0031062)3.23958354
115negative regulation of mitotic sister chromatid separation (GO:2000816)3.23218998
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23218998
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23218998
118negative regulation of sister chromatid segregation (GO:0033046)3.23218998
119sister chromatid segregation (GO:0000819)3.23147072
120paraxial mesoderm development (GO:0048339)3.22898145
121relaxation of smooth muscle (GO:0044557)3.22040529
122pore complex assembly (GO:0046931)3.21668585
123microtubule severing (GO:0051013)3.21028736
124chromosome segregation (GO:0007059)3.20392877
125primitive streak formation (GO:0090009)3.18360427
126rRNA modification (GO:0000154)3.18048264
127regulation of mitotic spindle organization (GO:0060236)3.17450879
128telomere maintenance via telomere lengthening (GO:0010833)3.17001785
129mitotic spindle checkpoint (GO:0071174)3.15743839
130mitotic recombination (GO:0006312)3.15524289
131chromatin assembly or disassembly (GO:0006333)3.15309114
132negative regulation of androgen receptor signaling pathway (GO:0060766)3.14757053
133regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13865340
134meiotic cell cycle (GO:0051321)3.13325437
135histone H4-K12 acetylation (GO:0043983)3.12884736
136negative regulation of histone methylation (GO:0031061)3.12591648
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12279009
138nucleotide-excision repair, DNA gap filling (GO:0006297)3.11733462
139regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11606635
140histone H3-K9 demethylation (GO:0033169)3.11220850
141labyrinthine layer development (GO:0060711)3.09370559
142spindle assembly checkpoint (GO:0071173)3.07278854
143regulation of sister chromatid segregation (GO:0033045)3.06449311
144regulation of mitotic sister chromatid separation (GO:0010965)3.06449311
145regulation of mitotic sister chromatid segregation (GO:0033047)3.06449311
146positive regulation of uterine smooth muscle contraction (GO:0070474)3.06083640
147positive regulation of reproductive process (GO:2000243)3.05961963
148mitotic spindle assembly checkpoint (GO:0007094)3.05796500
149protein localization to chromosome (GO:0034502)3.05679906
150regulation of double-strand break repair (GO:2000779)3.03876051
151determination of adult lifespan (GO:0008340)3.03151294
152phosphorelay signal transduction system (GO:0000160)3.03076973
153proteasome assembly (GO:0043248)2.99547491
154germ cell development (GO:0007281)2.99003651
155female gamete generation (GO:0007292)2.98492578
156sister chromatid cohesion (GO:0007062)2.95198602
157regulation of histone H3-K4 methylation (GO:0051569)2.93876058
158DNA damage induced protein phosphorylation (GO:0006975)2.90739974
159oocyte maturation (GO:0001556)2.84677125
160positive regulation of meiosis (GO:0045836)2.82814339
161negative regulation of cAMP-mediated signaling (GO:0043951)2.82509025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89159428
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.88330040
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.48115051
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.31624662
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.73038950
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.69584928
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57526054
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.57190999
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27787302
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.09977283
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.09977283
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.09977283
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87528014
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.77007138
15NANOG_18555785_ChIP-Seq_MESCs_Mouse2.74309338
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.69404963
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57628899
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54634068
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52654983
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50161169
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45653130
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.44884409
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34133782
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31955917
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28598123
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22895524
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19842562
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.15976176
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.10546447
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09005043
31AR_21909140_ChIP-Seq_LNCAP_Human2.08361259
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06132526
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.04148581
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02015274
35EZH2_22144423_ChIP-Seq_EOC_Human11.3760875
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98438532
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98400442
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94981728
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94020655
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.93415638
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91183359
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.85758660
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.82255435
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82112045
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80778748
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.77552943
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76595203
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.76228133
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.76147059
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72897924
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.68475589
52SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.67932712
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67491382
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63702737
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62472044
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59057875
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58986304
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53424824
59VDR_23849224_ChIP-Seq_CD4+_Human1.47605828
60XRN2_22483619_ChIP-Seq_HELA_Human1.46154252
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.43528577
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.37090856
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35957709
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32235188
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32155568
66CBP_20019798_ChIP-Seq_JUKART_Human1.32155568
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.31282597
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31003756
69NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.29404349
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29241561
71FOXP3_21729870_ChIP-Seq_TREG_Human1.28408171
72DCP1A_22483619_ChIP-Seq_HELA_Human1.27221840
73NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26891193
74NANOG_18692474_ChIP-Seq_MESCs_Mouse1.25778367
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25507173
76SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24958299
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24260049
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23225919
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23213062
80TTF2_22483619_ChIP-Seq_HELA_Human1.21536563
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21402929
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21267043
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20435559
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20095365
85KAP1_27257070_Chip-Seq_ESCs_Mouse1.19567356
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19119602
87GBX2_23144817_ChIP-Seq_PC3_Human1.18984925
88GABP_19822575_ChIP-Seq_HepG2_Human1.17798136
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.16554490
90NANOG_20526341_ChIP-Seq_ESCs_Human1.16109006
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15747848
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14830141
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14083543
94POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12642478
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.12387228
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09863663
97TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06844479
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06301096
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04593913
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04009181
101KDM5A_27292631_Chip-Seq_BREAST_Human1.03479857
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01645281
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00881598
104ELK1_19687146_ChIP-ChIP_HELA_Human1.00713454
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.00680956
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95855037
107HTT_18923047_ChIP-ChIP_STHdh_Human0.95510176
108NANOG_16518401_ChIP-PET_MESCs_Mouse0.94548253
109SRF_21415370_ChIP-Seq_HL-1_Mouse0.94017245
110CBP_21632823_ChIP-Seq_H3396_Human0.93923313
111AR_25329375_ChIP-Seq_VCAP_Human0.93743523
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93730247
113ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92343723
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.92263495
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91300706
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91072743
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90723044
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.90599916
119* EP300_21415370_ChIP-Seq_HL-1_Mouse0.90317075
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88775661
121PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87546546
122FOXH1_21741376_ChIP-Seq_EPCs_Human0.87012609
123MYC_18940864_ChIP-ChIP_HL60_Human0.85638498
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.84647242
125SALL4_22934838_ChIP-ChIP_CD34+_Human0.84614590
126TCF4_23295773_ChIP-Seq_U87_Human0.83730457
127* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81896972
128HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80895748
129IRF1_19129219_ChIP-ChIP_H3396_Human0.79884693
130* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79830825
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79580217
132TFEB_21752829_ChIP-Seq_HELA_Human0.79281995
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79206242
134ERG_20517297_ChIP-Seq_VCAP_Human0.75218344
135GF1_26923725_Chip-Seq_HPCs_Mouse0.75159449
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74475208
137SMAD4_21799915_ChIP-Seq_A2780_Human0.74401218
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73143812
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72851364
140* RUNX2_22187159_ChIP-Seq_PCA_Human0.70597631
141TAL1_26923725_Chip-Seq_HPCs_Mouse0.67387297
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.66590935
143STAT3_23295773_ChIP-Seq_U87_Human0.66379639
144TP53_22573176_ChIP-Seq_HFKS_Human0.65157233
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65085300
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.64675345
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.64576715
148EWS_26573619_Chip-Seq_HEK293_Human0.64492090
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.60476055
150ELF5_23300383_ChIP-Seq_T47D_Human0.60463394
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60101548
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.57073965
153SMRT_27268052_Chip-Seq_Bcells_Human0.56678190
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.56623026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.75721015
2MP0010094_abnormal_chromosome_stability4.67470267
3MP0008057_abnormal_DNA_replication4.64488209
4MP0003111_abnormal_nucleus_morphology4.54532065
5MP0008789_abnormal_olfactory_epithelium4.07047951
6MP0004957_abnormal_blastocyst_morpholog3.93400521
7MP0003077_abnormal_cell_cycle3.75256554
8MP0008058_abnormal_DNA_repair3.64807772
9MP0005360_urolithiasis3.52024519
10MP0008877_abnormal_DNA_methylation3.46558826
11MP0005394_taste/olfaction_phenotype3.45704831
12MP0005499_abnormal_olfactory_system3.45704831
13MP0010234_abnormal_vibrissa_follicle3.09088571
14MP0003718_maternal_effect3.01674375
15MP0002234_abnormal_pharynx_morphology2.74691091
16MP0002653_abnormal_ependyma_morphology2.73179368
17MP0008007_abnormal_cellular_replicative2.56978380
18MP0006292_abnormal_olfactory_placode2.56959937
19MP0003806_abnormal_nucleotide_metabolis2.41776171
20MP0003879_abnormal_hair_cell2.41703466
21MP0002139_abnormal_hepatobiliary_system2.37710816
22MP0008932_abnormal_embryonic_tissue2.35572949
23MP0002210_abnormal_sex_determination2.35103768
24MP0003786_premature_aging2.30001883
25MP0003123_paternal_imprinting2.24167355
26MP0001929_abnormal_gametogenesis2.23695214
27MP0003183_abnormal_peptide_metabolism2.11630162
28MP0002138_abnormal_hepatobiliary_system2.05780236
29MP0003136_yellow_coat_color2.02289447
30MP0000350_abnormal_cell_proliferation1.98856465
31MP0001145_abnormal_male_reproductive1.97493107
32MP0003941_abnormal_skin_development1.96606636
33MP0001730_embryonic_growth_arrest1.93290136
34MP0004133_heterotaxia1.89941530
35MP0000653_abnormal_sex_gland1.83937132
36MP0000762_abnormal_tongue_morphology1.78217217
37MP0002102_abnormal_ear_morphology1.76342288
38MP0010352_gastrointestinal_tract_polyps1.76060680
39MP0005410_abnormal_fertilization1.74999647
40MP0003646_muscle_fatigue1.68041749
41MP0003698_abnormal_male_reproductive1.66152152
42MP0010307_abnormal_tumor_latency1.64700212
43MP0002085_abnormal_embryonic_tissue1.64547704
44MP0001672_abnormal_embryogenesis/_devel1.64489020
45MP0005380_embryogenesis_phenotype1.64489020
46MP0003890_abnormal_embryonic-extraembry1.62534595
47MP0001119_abnormal_female_reproductive1.56688863
48MP0002084_abnormal_developmental_patter1.50161319
49MP0001697_abnormal_embryo_size1.48675152
50MP0003315_abnormal_perineum_morphology1.45108510
51MP0000678_abnormal_parathyroid_gland1.42923463
52MP0000490_abnormal_crypts_of1.39392026
53MP0002160_abnormal_reproductive_system1.37993073
54MP0009840_abnormal_foam_cell1.36185407
55MP0002086_abnormal_extraembryonic_tissu1.28448431
56MP0003984_embryonic_growth_retardation1.27873983
57MP0005395_other_phenotype1.25910320
58MP0001293_anophthalmia1.24240404
59MP0002088_abnormal_embryonic_growth/wei1.23919924
60MP0002161_abnormal_fertility/fecundity1.22474595
61MP0005451_abnormal_body_composition1.20959219
62MP0003121_genomic_imprinting1.20872878
63MP0002080_prenatal_lethality1.19951285
64MP0005646_abnormal_pituitary_gland1.18739523
65MP0005389_reproductive_system_phenotype1.18458489
66MP0008995_early_reproductive_senescence1.16803865
67MP0004197_abnormal_fetal_growth/weight/1.14952619
68MP0000313_abnormal_cell_death1.12386243
69MP0003699_abnormal_female_reproductive1.12124138
70MP0002019_abnormal_tumor_incidence1.09545149
71MP0002233_abnormal_nose_morphology1.09519412
72MP0005670_abnormal_white_adipose1.05174563
73MP0003186_abnormal_redox_activity1.03934286
74MP0003119_abnormal_digestive_system1.03110200
75MP0010368_abnormal_lymphatic_system1.02290797
76MP0002796_impaired_skin_barrier1.01210389
77MP0003787_abnormal_imprinting0.97731033
78MP0010678_abnormal_skin_adnexa0.97262470
79MP0000427_abnormal_hair_cycle0.97052245
80MP0005076_abnormal_cell_differentiation0.96485250
81MP0004264_abnormal_extraembryonic_tissu0.96371721
82MP0003937_abnormal_limbs/digits/tail_de0.95514759
83MP0001986_abnormal_taste_sensitivity0.93939650
84MP0000631_abnormal_neuroendocrine_gland0.92606813
85MP0003252_abnormal_bile_duct0.91988835
86MP0002249_abnormal_larynx_morphology0.91047674
87MP0005501_abnormal_skin_physiology0.90351758
88MP0008260_abnormal_autophagy0.89916427
89MP0005266_abnormal_metabolism0.88704476
90MP0003950_abnormal_plasma_membrane0.88358405
91MP0001984_abnormal_olfaction0.86033695
92MP0001919_abnormal_reproductive_system0.84642205
93MP0000049_abnormal_middle_ear0.82390128
94MP0002277_abnormal_respiratory_mucosa0.81957452
95MP0003936_abnormal_reproductive_system0.80752561
96MP0001286_abnormal_eye_development0.78694989
97MP0004142_abnormal_muscle_tone0.73807466
98MP0005408_hypopigmentation0.73480304
99MP0000516_abnormal_urinary_system0.73381297
100MP0005367_renal/urinary_system_phenotyp0.73381297
101MP0003567_abnormal_fetal_cardiomyocyte0.72659518
102MP0001849_ear_inflammation0.70897565
103MP0000432_abnormal_head_morphology0.70588677
104MP0005621_abnormal_cell_physiology0.70049124
105MP0010030_abnormal_orbit_morphology0.69679841
106MP0005384_cellular_phenotype0.69679753
107MP0002396_abnormal_hematopoietic_system0.69097188
108MP0002075_abnormal_coat/hair_pigmentati0.67787440
109MP0001915_intracranial_hemorrhage0.66219655
110MP0006276_abnormal_autonomic_nervous0.64604607
111MP0000371_diluted_coat_color0.64388335
112MP0002111_abnormal_tail_morphology0.63916243
113MP0000733_abnormal_muscle_development0.63207422
114MP0001186_pigmentation_phenotype0.61879334
115MP0003755_abnormal_palate_morphology0.59293141
116MP0003283_abnormal_digestive_organ0.59107937
117MP0009379_abnormal_foot_pigmentation0.58644639
118MP0000358_abnormal_cell_content/0.58270947
119MP0002089_abnormal_postnatal_growth/wei0.58212118
120MP0003861_abnormal_nervous_system0.57699403
121MP0003448_altered_tumor_morphology0.56684649
122MP0001963_abnormal_hearing_physiology0.55405944
123MP0003935_abnormal_craniofacial_develop0.55310255
124MP0003566_abnormal_cell_adhesion0.55000218
125MP0002272_abnormal_nervous_system0.54826455
126MP0005397_hematopoietic_system_phenotyp0.53413640
127MP0001545_abnormal_hematopoietic_system0.53413640
128MP0005647_abnormal_sex_gland0.52904098
129MP0002127_abnormal_cardiovascular_syste0.52573121
130MP0000858_altered_metastatic_potential0.52019414
131MP0004233_abnormal_muscle_weight0.49606839
132MP0005085_abnormal_gallbladder_physiolo0.49332746
133MP0000627_abnormal_mammary_gland0.48478528
134MP0000566_synostosis0.48420334
135MP0005551_abnormal_eye_electrophysiolog0.48334348
136MP0001881_abnormal_mammary_gland0.47895818
137MP0000377_abnormal_hair_follicle0.47142158
138MP0005023_abnormal_wound_healing0.46324190
139MP0001502_abnormal_circadian_rhythm0.44349402
140MP0001324_abnormal_eye_pigmentation0.43767859
141MP0001664_abnormal_digestion0.43313817
142MP0002269_muscular_atrophy0.42731759
143MP0002098_abnormal_vibrissa_morphology0.41941330
144MP0009250_abnormal_appendicular_skeleto0.41576835
145MP0000026_abnormal_inner_ear0.39410283
146MP0005319_abnormal_enzyme/_coenzyme0.37736577
147MP0005197_abnormal_uvea_morphology0.37407665
148MP0001666_abnormal_nutrient_absorption0.35668023

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.68399831
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.64619708
3Birth length less than 3rd percentile (HP:0003561)5.01103423
4Osteomalacia (HP:0002749)4.99469385
5Cholecystitis (HP:0001082)4.56560815
6Abnormal gallbladder physiology (HP:0012438)4.56560815
7Lip pit (HP:0100267)4.56212041
8Breast hypoplasia (HP:0003187)4.41672368
9Abnormality of the labia minora (HP:0012880)4.36498058
10Hypophosphatemic rickets (HP:0004912)4.33840994
11Oligodactyly (hands) (HP:0001180)4.24962005
12Supernumerary spleens (HP:0009799)4.03470374
13Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.98257631
14Abnormality of chromosome stability (HP:0003220)3.84547449
15Meckel diverticulum (HP:0002245)3.83634656
16Infertility (HP:0000789)3.83088984
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.71530566
18Absent radius (HP:0003974)3.69628941
19Abnormality of the ileum (HP:0001549)3.68920230
20Ependymoma (HP:0002888)3.65432776
21Abnormality of the preputium (HP:0100587)3.63316262
22Agnosia (HP:0010524)3.50863361
23Patellar aplasia (HP:0006443)3.47322241
24Absent forearm bone (HP:0003953)3.47296731
25Aplasia involving forearm bones (HP:0009822)3.47296731
26Carpal bone hypoplasia (HP:0001498)3.44730372
27Gonadotropin excess (HP:0000837)3.44312799
28Papillary thyroid carcinoma (HP:0002895)3.42991939
29Malnutrition (HP:0004395)3.42055443
30Medulloblastoma (HP:0002885)3.33379836
31Short tibia (HP:0005736)3.33368707
32Generalized aminoaciduria (HP:0002909)3.33141958
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.28369366
34Hypoplasia of the fovea (HP:0007750)3.25568323
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.25568323
36Absent septum pellucidum (HP:0001331)3.25437163
37Impulsivity (HP:0100710)3.23382433
38Anterior segment dysgenesis (HP:0007700)3.22053059
39Aplasia/Hypoplasia of the patella (HP:0006498)3.18436792
40Hypokinesia (HP:0002375)3.07979817
41Conjunctival telangiectasia (HP:0000524)3.05605523
42Sensory axonal neuropathy (HP:0003390)3.05505362
43Oligodactyly (HP:0012165)3.04965032
44Proximal tubulopathy (HP:0000114)3.01698012
45Wrist flexion contracture (HP:0001239)2.95308518
46Duplicated collecting system (HP:0000081)2.94259916
47Rhabdomyosarcoma (HP:0002859)2.93334319
48Aplasia of the musculature (HP:0100854)2.91093151
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.90179849
50Duodenal stenosis (HP:0100867)2.89596320
51Small intestinal stenosis (HP:0012848)2.89596320
52Shawl scrotum (HP:0000049)2.88696861
53Neoplasm of the oral cavity (HP:0100649)2.87399421
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.86035023
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.85821906
56Absent thumb (HP:0009777)2.85487948
57Abnormality of the fovea (HP:0000493)2.82486066
58Ectopic kidney (HP:0000086)2.81808706
59Abnormality of abdominal situs (HP:0011620)2.77346239
60Abdominal situs inversus (HP:0003363)2.77346239
61Abnormality of the septum pellucidum (HP:0007375)2.75055487
62Septo-optic dysplasia (HP:0100842)2.72489666
63Rib fusion (HP:0000902)2.72445298
64Stillbirth (HP:0003826)2.71738451
65Spinal cord compression (HP:0002176)2.70605415
66Aplasia/hypoplasia of the humerus (HP:0006507)2.69963155
67Capillary hemangiomas (HP:0005306)2.66084851
68Abnormality of the phalanges of the hallux (HP:0010057)2.62985925
69Sloping forehead (HP:0000340)2.62345982
70Rectal fistula (HP:0100590)2.59798570
71Rectovaginal fistula (HP:0000143)2.59798570
72Popliteal pterygium (HP:0009756)2.59211380
73Premature ovarian failure (HP:0008209)2.56632277
74Muscle stiffness (HP:0003552)2.56598083
75Selective tooth agenesis (HP:0001592)2.54308556
76Clubbing of toes (HP:0100760)2.52185835
77Abnormality of the renal collecting system (HP:0004742)2.51302286
78Myelodysplasia (HP:0002863)2.50856169
79Oral leukoplakia (HP:0002745)2.49999479
80Congenital sensorineural hearing impairment (HP:0008527)2.49602122
81Bone marrow hypocellularity (HP:0005528)2.49595651
82Urethral obstruction (HP:0000796)2.46789346
83Astrocytoma (HP:0009592)2.46759239
84Abnormality of the astrocytes (HP:0100707)2.46759239
85Skin pits (HP:0100276)2.46419144
86Breast aplasia (HP:0100783)2.45194589
87Metaphyseal irregularity (HP:0003025)2.43273877
88Short humerus (HP:0005792)2.42436662
89Adrenal hypoplasia (HP:0000835)2.41309074
90Abnormality of the duodenum (HP:0002246)2.39877476
91Nephroblastoma (Wilms tumor) (HP:0002667)2.36741167
92Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36663558
93Hydroureter (HP:0000072)2.36329082
94Abnormality of the anterior horn cell (HP:0006802)2.36041742
95Degeneration of anterior horn cells (HP:0002398)2.36041742
96Enlarged penis (HP:0000040)2.35449725
97Abnormality of the carotid arteries (HP:0005344)2.33682231
98Tracheoesophageal fistula (HP:0002575)2.32561893
99Apathy (HP:0000741)2.32389795
100Microglossia (HP:0000171)2.32055214
101Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32028396
102Loss of speech (HP:0002371)2.30943703
103Diminished motivation (HP:0000745)2.29625011
104Rough bone trabeculation (HP:0100670)2.28333156
105Ankle contracture (HP:0006466)2.27169314
106Triphalangeal thumb (HP:0001199)2.25025771
107Short thumb (HP:0009778)2.24329399
108Aplasia/Hypoplasia of the breasts (HP:0010311)2.24182971
109Intestinal fistula (HP:0100819)2.23924146
110Male infertility (HP:0003251)2.23078353
111Horseshoe kidney (HP:0000085)2.22619636
112Intrahepatic cholestasis (HP:0001406)2.21201682
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21047010
114Abnormal ciliary motility (HP:0012262)2.19549189
115Glioma (HP:0009733)2.17299223
116Embryonal renal neoplasm (HP:0011794)2.15675066
117Abnormal spermatogenesis (HP:0008669)2.14036252
118Aplasia/Hypoplasia of the sternum (HP:0006714)2.13601818
119Median cleft lip (HP:0000161)2.11274772
120Nausea (HP:0002018)2.10731430
121Abnormality of pyrimidine metabolism (HP:0004353)2.10000235
122Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09308516
123Neoplasm of striated muscle (HP:0009728)2.08806969
124Truncal obesity (HP:0001956)2.07524558
125Maternal diabetes (HP:0009800)2.04442071
126Facial hemangioma (HP:0000329)2.03120545
127Abnormality of lateral ventricle (HP:0030047)2.02501404
128Vaginal fistula (HP:0004320)2.00342081
129Colon cancer (HP:0003003)2.00285214
130Aplasia/Hypoplasia of the tongue (HP:0010295)2.00130649
131Reticulocytopenia (HP:0001896)1.99319339
132Heterotopia (HP:0002282)1.99176545
133Fair hair (HP:0002286)1.97633831
134Rhinitis (HP:0012384)1.97480524
135Absent/shortened dynein arms (HP:0200106)1.96920360
136Dynein arm defect of respiratory motile cilia (HP:0012255)1.96920360
137Cerebral hypomyelination (HP:0006808)1.96425846
138Tongue fasciculations (HP:0001308)1.95976225
139Facial cleft (HP:0002006)1.94246650
140Abnormality of the salivary glands (HP:0010286)1.93317709
141Secondary amenorrhea (HP:0000869)1.92547702
142Posterior subcapsular cataract (HP:0007787)1.92219945
143Aplasia/Hypoplasia of the macula (HP:0008059)1.91685070
144Abnormal lung lobation (HP:0002101)1.91178929
145Abnormal respiratory motile cilium physiology (HP:0012261)1.90531691
146Abnormality of cochlea (HP:0000375)1.90360767
147Breech presentation (HP:0001623)1.90004814
148High anterior hairline (HP:0009890)1.88967885
149Lower limb hyperreflexia (HP:0002395)1.88635686
150Sex reversal (HP:0012245)1.87828140
151Abnormal sex determination (HP:0012244)1.87828140
152Abnormality of DNA repair (HP:0003254)1.86789445
153Azoospermia (HP:0000027)1.86731750
154Preauricular pit (HP:0004467)1.86454411
155Periauricular skin pits (HP:0100277)1.86454411
156Amaurosis fugax (HP:0100576)1.85860959
157Subcapsular cataract (HP:0000523)1.85211819
158Absent hand (HP:0004050)1.84912630
159Neoplasm of the pancreas (HP:0002894)1.84407804
160Rickets (HP:0002748)1.83946879
161Thyroid carcinoma (HP:0002890)1.81809711
162Premature graying of hair (HP:0002216)1.81662253
163Abnormality of calcium-phosphate metabolism (HP:0100530)1.80396519
164Abnormal trabecular bone morphology (HP:0100671)1.80007718
165Aplasia/Hypoplasia of the earlobes (HP:0009906)1.79525161
166Chronic bronchitis (HP:0004469)1.79345426
167Cafe-au-lait spot (HP:0000957)1.79316215
168Biliary tract neoplasm (HP:0100574)1.78340732
169Cortical dysplasia (HP:0002539)1.78283957
170Anhidrosis (HP:0000970)1.77246552
171Hypohidrosis (HP:0000966)1.76506235
172Supernumerary bones of the axial skeleton (HP:0009144)1.74773220
173Cleft eyelid (HP:0000625)1.73874945
174Abnormality of sulfur amino acid metabolism (HP:0004339)1.73796337
175Aplasia/Hypoplasia affecting the retina (HP:0008061)1.72142914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K135.34625403
2TTK3.95385757
3WEE13.82621952
4CDC73.71484850
5BUB13.55142681
6STK243.21120900
7PLK43.02929703
8EPHA23.00515230
9MET2.86808295
10NEK62.82210057
11CDK122.80300051
12STK38L2.77434936
13NEK22.75050272
14PLK12.46168265
15NEK12.40544093
16SRPK12.21227846
17EIF2AK12.17728140
18CHEK22.03824681
19AKT31.98221240
20PDK31.94242398
21PDK41.94242398
22TAOK31.94148047
23PDK21.89844231
24CDK71.84069903
25LATS21.82436587
26RPS6KB21.68830097
27ZAK1.66809680
28ATR1.65844607
29PLK31.63414804
30LATS11.55748633
31BRAF1.52625342
32TSSK61.51466922
33AURKB1.47417191
34PNCK1.47058088
35ACVR1B1.42173016
36AURKA1.39557100
37ERBB41.38922697
38CHEK11.35122615
39VRK11.28760042
40KSR11.28678551
41MAP3K61.24384841
42MAPKAPK31.23915245
43DYRK31.17365996
44ATM1.13697586
45EIF2AK31.11326960
46STK31.10463307
47MKNK21.08503705
48PTK21.08035365
49TRIM281.07937284
50DYRK21.07634282
51MAP3K81.07615934
52CDK41.03573381
53STK101.00776464
54BRSK21.00699182
55NTRK21.00335678
56MELK0.95786645
57NUAK10.94940143
58PIM10.94703150
59PASK0.93195114
60STK40.92993547
61TLK10.91479715
62STK160.91288755
63CDK190.89991346
64STK380.88516210
65EEF2K0.88244632
66PBK0.88115052
67CDK20.87842427
68NEK90.87538367
69BMPR20.86869617
70MKNK10.84749803
71PRKCI0.82468260
72PINK10.80015957
73MOS0.77073184
74ALK0.75510635
75IRAK30.74814534
76EIF2AK20.72477566
77MST40.72043716
78BRD40.71242288
79CDK10.69018217
80PAK40.67360060
81CDK80.66140975
82STK390.64353821
83CSNK2A10.58851402
84YES10.57647861
85BRSK10.55647157
86DMPK0.55516411
87CSNK2A20.54018407
88PAK10.51375736
89CSNK1G10.50478877
90CSNK1D0.50249822
91CDK90.49795575
92LMTK20.48843472
93MAP3K30.48501490
94BMPR1B0.47870757
95TNIK0.45655360
96MUSK0.45357745
97TESK20.44954285
98MST1R0.44900292
99NTRK30.44403986
100MAP3K90.42956062
101CSNK1E0.41990430
102PKN10.41011128
103TIE10.39451510
104RAF10.39416282
105KSR20.38793939
106VRK20.37857809
107CDK60.37668352
108ICK0.37262356
109LRRK20.36864501
110RPS6KA40.36013902
111CSNK1G30.35691600
112AKT20.35072542
113PRKG10.34769883
114PRKDC0.32167476
115WNK10.32032141
116PDPK10.31294212
117MAP2K10.31046912
118PDK10.30946603
119MAP3K50.30807389
120GRK10.30425498
121MAPK140.30154021
122MARK30.29398893
123TESK10.29176492
124MTOR0.28223867
125ILK0.27635267
126GSK3B0.26600017
127PRKD30.26176220
128OXSR10.25687121
129CAMK2A0.24106294
130WNK30.24012240
131ARAF0.23805974
132NME20.23654900
133AKT10.23316886
134MAPK10.23192558
135ABL20.22935520
136CCNB10.22617459
137RPS6KA50.21926383
138TGFBR10.21786021
139MAP3K120.19436718
140TNK20.18922574
141EGFR0.18398033
142CSNK1A1L0.17860489
143PRKACB0.16524325

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.50839287
2DNA replication_Homo sapiens_hsa030304.45807322
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07296115
4Homologous recombination_Homo sapiens_hsa034403.54583636
5Fanconi anemia pathway_Homo sapiens_hsa034603.39480605
6RNA transport_Homo sapiens_hsa030133.28363946
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.25399391
8RNA polymerase_Homo sapiens_hsa030203.15943710
9Cell cycle_Homo sapiens_hsa041103.07472464
10One carbon pool by folate_Homo sapiens_hsa006702.95484272
11Nucleotide excision repair_Homo sapiens_hsa034202.88240296
12Base excision repair_Homo sapiens_hsa034102.86966740
13Basal transcription factors_Homo sapiens_hsa030222.80933407
14Spliceosome_Homo sapiens_hsa030402.54813233
15Non-homologous end-joining_Homo sapiens_hsa034502.47305204
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43217054
17RNA degradation_Homo sapiens_hsa030182.40353699
18Caffeine metabolism_Homo sapiens_hsa002322.30242755
19Proteasome_Homo sapiens_hsa030502.30207755
20Pyrimidine metabolism_Homo sapiens_hsa002402.24077477
21mRNA surveillance pathway_Homo sapiens_hsa030151.85502324
22Vitamin B6 metabolism_Homo sapiens_hsa007501.80683460
23p53 signaling pathway_Homo sapiens_hsa041151.77923808
24Olfactory transduction_Homo sapiens_hsa047401.77347023
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76805639
26Ribosome_Homo sapiens_hsa030101.44592693
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36692415
28Purine metabolism_Homo sapiens_hsa002301.36182876
29Fatty acid elongation_Homo sapiens_hsa000621.29411347
30Oocyte meiosis_Homo sapiens_hsa041141.27031342
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08545708
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06744339
33Linoleic acid metabolism_Homo sapiens_hsa005911.02962018
34Epstein-Barr virus infection_Homo sapiens_hsa051691.02710918
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.98883572
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96705495
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.96288418
38TGF-beta signaling pathway_Homo sapiens_hsa043500.92086480
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91544467
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90129630
41Folate biosynthesis_Homo sapiens_hsa007900.89667514
42Biosynthesis of amino acids_Homo sapiens_hsa012300.87834513
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86493891
44Herpes simplex infection_Homo sapiens_hsa051680.85501638
45Selenocompound metabolism_Homo sapiens_hsa004500.85292196
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84751883
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83334879
48Gap junction_Homo sapiens_hsa045400.82612969
49Arachidonic acid metabolism_Homo sapiens_hsa005900.81048176
50Synaptic vesicle cycle_Homo sapiens_hsa047210.75891539
51Viral carcinogenesis_Homo sapiens_hsa052030.70324502
52Systemic lupus erythematosus_Homo sapiens_hsa053220.70286453
53Phototransduction_Homo sapiens_hsa047440.70181732
54Glutathione metabolism_Homo sapiens_hsa004800.69637001
55Fructose and mannose metabolism_Homo sapiens_hsa000510.69447371
56ABC transporters_Homo sapiens_hsa020100.64827607
57Sulfur metabolism_Homo sapiens_hsa009200.63802433
58Hippo signaling pathway_Homo sapiens_hsa043900.62931538
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.60696316
60Pentose phosphate pathway_Homo sapiens_hsa000300.60167301
61Other glycan degradation_Homo sapiens_hsa005110.59252184
62Sulfur relay system_Homo sapiens_hsa041220.58771478
63MicroRNAs in cancer_Homo sapiens_hsa052060.58333329
64Arginine biosynthesis_Homo sapiens_hsa002200.56348883
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55182525
66Morphine addiction_Homo sapiens_hsa050320.54980627
67Nicotine addiction_Homo sapiens_hsa050330.52165021
68Notch signaling pathway_Homo sapiens_hsa043300.51246847
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51220414
70HTLV-I infection_Homo sapiens_hsa051660.49680628
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48707411
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47763468
73GABAergic synapse_Homo sapiens_hsa047270.46918955
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44296469
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.44257317
76Ether lipid metabolism_Homo sapiens_hsa005650.43841210
77Arginine and proline metabolism_Homo sapiens_hsa003300.43765100
78Pyruvate metabolism_Homo sapiens_hsa006200.41718081
79Graft-versus-host disease_Homo sapiens_hsa053320.41250519
80Basal cell carcinoma_Homo sapiens_hsa052170.39848494
81Huntingtons disease_Homo sapiens_hsa050160.39755793
82Legionellosis_Homo sapiens_hsa051340.38966404
83Adherens junction_Homo sapiens_hsa045200.38769417
84Bile secretion_Homo sapiens_hsa049760.38378926
85Antigen processing and presentation_Homo sapiens_hsa046120.38110992
86Propanoate metabolism_Homo sapiens_hsa006400.38038912
87Taste transduction_Homo sapiens_hsa047420.36940423
88Regulation of autophagy_Homo sapiens_hsa041400.36816216
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36286067
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36110042
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35557075
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35440573
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35377216
94Vitamin digestion and absorption_Homo sapiens_hsa049770.31394076
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31243723
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.29624603
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28251555
98Colorectal cancer_Homo sapiens_hsa052100.27765313
99Thyroid cancer_Homo sapiens_hsa052160.27485847
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27341654
101Small cell lung cancer_Homo sapiens_hsa052220.27291503
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.26272498
103Influenza A_Homo sapiens_hsa051640.25939400
104Serotonergic synapse_Homo sapiens_hsa047260.25792900
105Hedgehog signaling pathway_Homo sapiens_hsa043400.25616245
106Carbon metabolism_Homo sapiens_hsa012000.24184673
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22873659
108Circadian rhythm_Homo sapiens_hsa047100.21522505
109Metabolic pathways_Homo sapiens_hsa011000.21041969
110Vibrio cholerae infection_Homo sapiens_hsa051100.20656074
111Apoptosis_Homo sapiens_hsa042100.20199376
112Tight junction_Homo sapiens_hsa045300.18930359
113Pathways in cancer_Homo sapiens_hsa052000.18411366
114ErbB signaling pathway_Homo sapiens_hsa040120.17378140
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17309057
116Collecting duct acid secretion_Homo sapiens_hsa049660.14234106
117mTOR signaling pathway_Homo sapiens_hsa041500.14234099
118Ovarian steroidogenesis_Homo sapiens_hsa049130.14144252
119Fatty acid biosynthesis_Homo sapiens_hsa000610.14054535
120HIF-1 signaling pathway_Homo sapiens_hsa040660.13352755
121Melanoma_Homo sapiens_hsa052180.13045441
122Long-term depression_Homo sapiens_hsa047300.12935020
123Wnt signaling pathway_Homo sapiens_hsa043100.12758174
124Prostate cancer_Homo sapiens_hsa052150.12256662
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10903922
126Sphingolipid metabolism_Homo sapiens_hsa006000.09292121
127Measles_Homo sapiens_hsa051620.08424532
128Endometrial cancer_Homo sapiens_hsa052130.08332295
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07945319
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07462581
131Type I diabetes mellitus_Homo sapiens_hsa049400.07231919
132Dorso-ventral axis formation_Homo sapiens_hsa043200.06635639
133Galactose metabolism_Homo sapiens_hsa000520.05068366
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04788569
135Alcoholism_Homo sapiens_hsa050340.04512017
136Steroid biosynthesis_Homo sapiens_hsa001000.04488228
137Allograft rejection_Homo sapiens_hsa053300.04128033
138FoxO signaling pathway_Homo sapiens_hsa040680.03961005
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.03656805
140Cardiac muscle contraction_Homo sapiens_hsa042600.03367170
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03189235
142Inositol phosphate metabolism_Homo sapiens_hsa005620.03172436

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