ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glycine transport (GO:0015816)	5.01320433
2	acrosome reaction (GO:0007340)	4.34910460
3	fusion of sperm to egg plasma membrane (GO:0007342)	4.05262720
4	microtubule severing (GO:0051013)	4.01481146
5	positive regulation of synapse maturation (GO:0090129)	3.91977978
6	sperm capacitation (GO:0048240)	3.91218079
7	sperm motility (GO:0030317)	3.90320588
8	regulation of synapse maturation (GO:0090128)	3.78450087
9	cellular ketone body metabolic process (GO:0046950)	3.68011949
10	synaptic vesicle exocytosis (GO:0016079)	3.44724080
11	growth hormone secretion (GO:0030252)	3.40544715
12	activation of protein kinase A activity (GO:0034199)	3.38243780
13	gamma-aminobutyric acid transport (GO:0015812)	3.37268354
14	regulation of ARF protein signal transduction (GO:0032012)	3.26248200
15	plasma membrane fusion (GO:0045026)	3.24968316
16	ketone body metabolic process (GO:1902224)	3.19306632
17	regulation of somitogenesis (GO:0014807)	3.18717019
18	neuronal ion channel clustering (GO:0045161)	3.11142568
19	response to pheromone (GO:0019236)	3.10666489
20	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.07902074
21	negative regulation of inclusion body assembly (GO:0090084)	2.99944799
22	cell-cell junction maintenance (GO:0045217)	2.99870916
23	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.99583973
24	receptor recycling (GO:0001881)	2.98850853
25	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.98668750
26	DNA topological change (GO:0006265)	2.97553280
27	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.97146701
28	positive regulation of Rab GTPase activity (GO:0032851)	2.93797827
29	regulation of Rab GTPase activity (GO:0032313)	2.93797827
30	protein targeting to Golgi (GO:0000042)	2.93118312
31	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.89422957
32	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.88402093
33	sexual reproduction (GO:0019953)	2.84432784
34	macroautophagy (GO:0016236)	2.84214800
35	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.84039963
36	DNA integration (GO:0015074)	2.82365857
37	Golgi transport vesicle coating (GO:0048200)	2.81000599
38	COPI coating of Golgi vesicle (GO:0048205)	2.81000599
39	vocalization behavior (GO:0071625)	2.73836620
40	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.72822496
41	muscle hypertrophy in response to stress (GO:0003299)	2.72822496
42	cardiac muscle adaptation (GO:0014887)	2.72822496
43	negative regulation of cell size (GO:0045792)	2.72630795
44	regulation of protein kinase A signaling (GO:0010738)	2.69276582
45	cell junction maintenance (GO:0034331)	2.69235871
46	calcium ion-dependent exocytosis (GO:0017156)	2.68670885
47	seminiferous tubule development (GO:0072520)	2.64258540
48	establishment of protein localization to Golgi (GO:0072600)	2.63309025
49	poly(A)+ mRNA export from nucleus (GO:0016973)	2.62533465
50	regulation of ARF GTPase activity (GO:0032312)	2.62526538
51	nerve growth factor signaling pathway (GO:0038180)	2.58737835
52	glomerular visceral epithelial cell development (GO:0072015)	2.58536893
53	spermatid development (GO:0007286)	2.56463252
54	leukotriene biosynthetic process (GO:0019370)	2.55536565
55	neuronal action potential propagation (GO:0019227)	2.55491989
56	regulation of NFAT protein import into nucleus (GO:0051532)	2.54971377
57	microtubule depolymerization (GO:0007019)	2.53069124
58	glomerular epithelial cell development (GO:0072310)	2.52708675
59	neurotransmitter-gated ion channel clustering (GO:0072578)	2.51865606
60	spermatid nucleus differentiation (GO:0007289)	2.50672859
61	RNA localization (GO:0006403)	2.48894182
62	establishment of apical/basal cell polarity (GO:0035089)	2.46475330
63	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.46441609
64	chromosome condensation (GO:0030261)	2.46104415
65	cellular component maintenance (GO:0043954)	2.45402141
66	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.44886628
67	reproduction (GO:0000003)	2.42866950
68	multicellular organism reproduction (GO:0032504)	2.42280720
69	protein retention in ER lumen (GO:0006621)	2.40250044
70	mitochondrial fusion (GO:0008053)	2.39872017
71	intracellular estrogen receptor signaling pathway (GO:0030520)	2.34507969
72	chromatin silencing (GO:0006342)	2.34324758
73	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.32915122
74	negative regulation of actin filament depolymerization (GO:0030835)	2.32784446
75	stress fiber assembly (GO:0043149)	2.32091967
76	cell migration in hindbrain (GO:0021535)	2.29590446
77	neurotransmitter secretion (GO:0007269)	2.29530370
78	vesicle transport along microtubule (GO:0047496)	2.28375426
79	protein polyglutamylation (GO:0018095)	2.27788828
80	cardiac muscle hypertrophy (GO:0003300)	2.26402061
81	SMAD protein complex assembly (GO:0007183)	2.26373285
82	long-term memory (GO:0007616)	2.24337409
83	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.23450792
84	protein localization to endosome (GO:0036010)	2.22611964
85	barbed-end actin filament capping (GO:0051016)	2.22453919
86	peptidyl-proline hydroxylation (GO:0019511)	2.22100043
87	negative regulation of gene expression, epigenetic (GO:0045814)	2.21877514
88	striated muscle hypertrophy (GO:0014897)	2.21230723
89	protein localization to Golgi apparatus (GO:0034067)	2.20890591
90	myoblast fusion (GO:0007520)	2.19472026
91	syncytium formation by plasma membrane fusion (GO:0000768)	2.19243400
92	cellular response to nerve growth factor stimulus (GO:1990090)	2.19092535
93	response to nerve growth factor (GO:1990089)	2.19092535
94	neuron recognition (GO:0008038)	2.18934506
95	cilium or flagellum-dependent cell motility (GO:0001539)	2.18721446
96	cerebellar granule cell differentiation (GO:0021707)	2.18644800
97	nucleus organization (GO:0006997)	2.18126467
98	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.17891893
99	adherens junction assembly (GO:0034333)	2.16818541
100	DNA packaging (GO:0006323)	2.16351249

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.05370513
2	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.02846965
3	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.69578663
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.55208026
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.54733557
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.33240001
7	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.30845414
8	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.27651392
9	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.15017351
10	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.03098394
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.97093766
12	KDM2B_26808549_Chip-Seq_K562_Human	1.93120383
13	CTCF_27219007_Chip-Seq_Bcells_Human	1.90350646
14	SMC4_20622854_ChIP-Seq_HELA_Human	1.85917205
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.77153356
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.73093584
17	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.72937189
18	P68_20966046_ChIP-Seq_HELA_Human	1.72339999
19	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.69299383
20	KDM2B_26808549_Chip-Seq_DND41_Human	1.68933213
21	TP53_22127205_ChIP-Seq_IMR90_Human	1.61867383
22	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.60924395
23	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.57130469
24	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.53030555
25	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.51697232
26	TCF7_22412390_ChIP-Seq_EML_Mouse	1.49705785
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.49320449
28	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.44404159
29	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.43901329
30	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.42859209
31	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.41967668
32	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.37636095
33	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.37559571
34	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.37482411
35	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.35639265
36	TP63_22573176_ChIP-Seq_HFKS_Human	1.35575046
37	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33033585
38	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.32690294
39	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.32354238
40	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.32149146
41	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.31031226
42	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.29662869
43	RACK7_27058665_Chip-Seq_MCF-7_Human	1.26941050
44	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.26305463
45	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.25665535
46	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.23878046
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23870070
48	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.23239468
49	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.22983773
50	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.22927579
51	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.20447461
52	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.19029344
53	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.18704089
54	PHF8_20622854_ChIP-Seq_HELA_Human	1.17013479
55	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.16429840
56	BCOR_27268052_Chip-Seq_Bcells_Human	1.15718236
57	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.14793840
58	E2F1_20622854_ChIP-Seq_HELA_Human	1.14719271
59	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.13461023
60	GATA1_19941826_ChIP-Seq_K562_Human	1.12968710
61	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11619311
62	CREB1_26743006_Chip-Seq_LNCaP_Human	1.10892531
63	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.10581235
64	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.10045863
65	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.09282996
66	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.08195226
67	OCT4_19829295_ChIP-Seq_ESCs_Human	1.07588318
68	SA1_27219007_Chip-Seq_Bcells_Human	1.06825125
69	RAC3_21632823_ChIP-Seq_H3396_Human	1.06509178
70	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05803772
71	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.05074242
72	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.04902359
73	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.04837629
74	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.04345349
75	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.01489028
76	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.01030629
77	BCL6_27268052_Chip-Seq_Bcells_Human	1.00322324
78	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.00149857
79	KLF4_19829295_ChIP-Seq_ESCs_Human	0.99700490
80	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.99575234
81	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99216121
82	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.97634234
83	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.97572053
84	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.97572053
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.97365892
86	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97031126
87	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.96840835
88	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.96440948
89	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.96012550
90	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.94646207
91	CTCF_21964334_Chip-Seq_Bcells_Human	0.94245137
92	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.93660601
93	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.93484149
94	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91989501
95	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.91559844
96	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.91071165
97	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.90957650
98	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.90957650
99	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.89000456
100	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.88542562

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	6.81299896
2	MP0004859_abnormal_synaptic_plasticity	4.39388593
3	MP0000013_abnormal_adipose_tissue	3.52862886
4	MP0008995_early_reproductive_senescence	3.38404860
5	MP0005410_abnormal_fertilization	3.37786993
6	MP0001986_abnormal_taste_sensitivity	3.28924257
7	MP0009384_cardiac_valve_regurgitation	3.25865432
8	MP0001873_stomach_inflammation	3.07540850
9	MP0009840_abnormal_foam_cell	2.72461531
10	MP0005409_darkened_coat_color	2.71195937
11	MP0002735_abnormal_chemical_nociception	2.61033573
12	MP0008260_abnormal_autophagy	2.39211189
13	MP0005670_abnormal_white_adipose	2.34851986
14	MP0005451_abnormal_body_composition	2.17969333
15	MP0000751_myopathy	2.06652234
16	MP0000613_abnormal_salivary_gland	1.93471079
17	MP0001348_abnormal_lacrimal_gland	1.84587810
18	MP0000003_abnormal_adipose_tissue	1.82460556
19	MP0003279_aneurysm	1.70770588
20	MP0004270_analgesia	1.59879676
21	MP0004510_myositis	1.58979236
22	MP0003385_abnormal_body_wall	1.57746643
23	MP0003635_abnormal_synaptic_transmissio	1.54600347
24	MP0004233_abnormal_muscle_weight	1.53618452
25	MP0004858_abnormal_nervous_system	1.53103340
26	MP0001968_abnormal_touch/_nociception	1.50482336
27	MP0002249_abnormal_larynx_morphology	1.49038078
28	MP0000750_abnormal_muscle_regeneration	1.47582530
29	MP0000678_abnormal_parathyroid_gland	1.42518496
30	MP0003172_abnormal_lysosome_physiology	1.41599792
31	MP0001849_ear_inflammation	1.40303070
32	MP0003705_abnormal_hypodermis_morpholog	1.39593009
33	MP0005377_hearing/vestibular/ear_phenot	1.36978725
34	MP0003878_abnormal_ear_physiology	1.36978725
35	MP0005623_abnormal_meninges_morphology	1.29490570
36	MP0000733_abnormal_muscle_development	1.27904993
37	MP0005171_absent_coat_pigmentation	1.25730784
38	MP0003329_amyloid_beta_deposits	1.24622799
39	MP0005423_abnormal_somatic_nervous	1.23435480
40	MP0000759_abnormal_skeletal_muscle	1.22815671
41	MP0001958_emphysema	1.20402693
42	MP0005375_adipose_tissue_phenotype	1.19336109
43	MP0004272_abnormal_basement_membrane	1.18360688
44	MP0008438_abnormal_cutaneous_collagen	1.08291398
45	MP0003091_abnormal_cell_migration	1.07782799
46	MP0003698_abnormal_male_reproductive	1.07176744
47	MP0000681_abnormal_thyroid_gland	1.04742491
48	MP0000534_abnormal_ureter_morphology	1.04055286
49	MP0005248_abnormal_Harderian_gland	1.03318180
50	MP0001270_distended_abdomen	0.99789847
51	MP0002736_abnormal_nociception_after	0.98934490
52	MP0002877_abnormal_melanocyte_morpholog	0.98549082
53	MP0002127_abnormal_cardiovascular_syste	0.92067481
54	MP0002108_abnormal_muscle_morphology	0.91275895
55	MP0002269_muscular_atrophy	0.90499964
56	MP0005367_renal/urinary_system_phenotyp	0.89869357
57	MP0000516_abnormal_urinary_system	0.89869357
58	MP0005620_abnormal_muscle_contractility	0.89137843
59	MP0002063_abnormal_learning/memory/cond	0.88271140
60	MP0006138_congestive_heart_failure	0.87883947
61	MP0005076_abnormal_cell_differentiation	0.85574857
62	MP0004087_abnormal_muscle_fiber	0.83952747
63	MP0003828_pulmonary_edema	0.82279711
64	MP0004947_skin_inflammation	0.82227698
65	MP0003303_peritoneal_inflammation	0.80774674
66	MP0002733_abnormal_thermal_nociception	0.80583836
67	MP0005503_abnormal_tendon_morphology	0.80139293
68	MP0003935_abnormal_craniofacial_develop	0.79192634
69	MP0001502_abnormal_circadian_rhythm	0.78505927
70	MP0008874_decreased_physiological_sensi	0.77580076
71	MP0003566_abnormal_cell_adhesion	0.77392678
72	MP0004130_abnormal_muscle_cell	0.76818294
73	MP0004142_abnormal_muscle_tone	0.76552422
74	MP0003221_abnormal_cardiomyocyte_apopto	0.76232148
75	MP0001299_abnormal_eye_distance/	0.73999059
76	MP0003690_abnormal_glial_cell	0.72734094
77	MP0001929_abnormal_gametogenesis	0.72467356
78	MP0008569_lethality_at_weaning	0.72349141
79	MP0004036_abnormal_muscle_relaxation	0.71410848
80	MP0005369_muscle_phenotype	0.70495565
81	MP0002234_abnormal_pharynx_morphology	0.69235898
82	MP0002106_abnormal_muscle_physiology	0.69036070
83	MP0002896_abnormal_bone_mineralization	0.68897469
84	MP0004084_abnormal_cardiac_muscle	0.68762847
85	MP0002132_abnormal_respiratory_system	0.68665252
86	MP0002161_abnormal_fertility/fecundity	0.68119536
87	MP0001970_abnormal_pain_threshold	0.67531149
88	MP0005666_abnormal_adipose_tissue	0.66521984
89	MP0003137_abnormal_impulse_conducting	0.66217503
90	MP0000767_abnormal_smooth_muscle	0.64008353
91	MP0002972_abnormal_cardiac_muscle	0.62188609
92	MP0001175_abnormal_lung_morphology	0.60542979
93	MP0001486_abnormal_startle_reflex	0.60070127
94	MP0004811_abnormal_neuron_physiology	0.59030906
95	MP0000465_gastrointestinal_hemorrhage	0.58776324
96	MP0001664_abnormal_digestion	0.57268839
97	MP0005257_abnormal_intraocular_pressure	0.55899109
98	MP0000747_muscle_weakness	0.55596571
99	MP0000604_amyloidosis	0.52887004
100	MP0003634_abnormal_glial_cell	0.52612698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Unilateral renal agenesis (HP:0000122)	4.84935708
2	Termporal pattern (HP:0011008)	4.07216533
3	Insidious onset (HP:0003587)	4.07216533
4	Subaortic stenosis (HP:0001682)	3.58661544
5	Abnormality of the left ventricular outflow tract (HP:0011103)	3.58661544
6	Male infertility (HP:0003251)	3.09912501
7	Distal lower limb amyotrophy (HP:0008944)	2.96784467
8	Spastic gait (HP:0002064)	2.94581522
9	Ankle clonus (HP:0011448)	2.83402703
10	Hyperacusis (HP:0010780)	2.80497528
11	Lower limb amyotrophy (HP:0007210)	2.68423116
12	Asymmetric septal hypertrophy (HP:0001670)	2.63323636
13	Epidermoid cyst (HP:0200040)	2.57683162
14	Neoplasm of the heart (HP:0100544)	2.56962086
15	Obstructive sleep apnea (HP:0002870)	2.52878778
16	Exercise-induced myalgia (HP:0003738)	2.52031176
17	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.50315782
18	Abnormality of the periventricular white matter (HP:0002518)	2.44671708
19	Hepatoblastoma (HP:0002884)	2.43634289
20	Hyperkalemia (HP:0002153)	2.42128032
21	Shallow orbits (HP:0000586)	2.40648100
22	Increased connective tissue (HP:0009025)	2.36580686
23	Renovascular hypertension (HP:0100817)	2.35568415
24	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.32940053
25	Severe visual impairment (HP:0001141)	2.32776989
26	Lower limb muscle weakness (HP:0007340)	2.24949977
27	Intellectual disability, moderate (HP:0002342)	2.22235537
28	Progressive sensorineural hearing impairment (HP:0000408)	2.20662297
29	Distal upper limb amyotrophy (HP:0007149)	2.18853413
30	Upper limb amyotrophy (HP:0009129)	2.18853413
31	Myopathic facies (HP:0002058)	2.18534580
32	Increased variability in muscle fiber diameter (HP:0003557)	2.16388280
33	Mildly elevated creatine phosphokinase (HP:0008180)	2.16207504
34	Urinary bladder sphincter dysfunction (HP:0002839)	2.11292933
35	Chronic hepatic failure (HP:0100626)	2.09243324
36	Broad ribs (HP:0000885)	2.08768868
37	Spina bifida occulta (HP:0003298)	2.05948712
38	Aneurysm (HP:0002617)	2.04679390
39	Abnormality of the pubic bones (HP:0003172)	2.04657447
40	Broad face (HP:0000283)	2.01211958
41	Arterial tortuosity (HP:0005116)	2.00814561
42	Protrusio acetabuli (HP:0003179)	1.96014715
43	Hydroureter (HP:0000072)	1.95662007
44	Bowel incontinence (HP:0002607)	1.92626750
45	Type 1 muscle fiber predominance (HP:0003803)	1.92259295
46	Lymphangioma (HP:0100764)	1.92210732
47	Hand muscle atrophy (HP:0009130)	1.92189006
48	Vertebral clefting (HP:0008428)	1.90848865
49	Bundle branch block (HP:0011710)	1.89017847
50	Vascular tortuosity (HP:0004948)	1.88926540
51	Hemorrhage of the eye (HP:0011885)	1.87835241
52	Abnormality of skeletal muscle fiber size (HP:0012084)	1.87044501
53	Long toe (HP:0010511)	1.86933449
54	Rhizomelia (HP:0008905)	1.86624708
55	Ulnar bowing (HP:0003031)	1.85498643
56	Flat acetabular roof (HP:0003180)	1.85215547
57	Atrophic scars (HP:0001075)	1.82410922
58	Aplasia involving bones of the extremities (HP:0009825)	1.82183600
59	Aplasia involving bones of the upper limbs (HP:0009823)	1.82183600
60	Aplasia of the phalanges of the hand (HP:0009802)	1.82183600
61	Atrioventricular block (HP:0001678)	1.81780028
62	Back pain (HP:0003418)	1.81249523
63	Cervical subluxation (HP:0003308)	1.81223929
64	Open mouth (HP:0000194)	1.80350187
65	Abnormality of the aortic arch (HP:0012303)	1.77341967
66	Ventricular tachycardia (HP:0004756)	1.76540477
67	Cerebral aneurysm (HP:0004944)	1.76387250
68	Bladder diverticulum (HP:0000015)	1.76253349
69	Thin bony cortex (HP:0002753)	1.76002150
70	Papilledema (HP:0001085)	1.75922455
71	Long clavicles (HP:0000890)	1.75916731
72	Abnormal atrioventricular conduction (HP:0005150)	1.75693379
73	Absent speech (HP:0001344)	1.75187437
74	Abnormality of the corticospinal tract (HP:0002492)	1.73358129
75	Precocious puberty (HP:0000826)	1.72811471
76	Broad palm (HP:0001169)	1.72495382
77	Abnormal large intestine physiology (HP:0012700)	1.71290034
78	Heart block (HP:0012722)	1.70667042
79	Drooling (HP:0002307)	1.66603888
80	Nasal polyposis (HP:0100582)	1.66071049
81	Impaired vibration sensation in the lower limbs (HP:0002166)	1.65953430
82	Abnormality of the parathyroid morphology (HP:0011766)	1.65622095
83	Excessive salivation (HP:0003781)	1.65439981
84	Spinal canal stenosis (HP:0003416)	1.64795053
85	Complete atrioventricular canal defect (HP:0001674)	1.64697996
86	Deformed sella turcica (HP:0002681)	1.64376557
87	Exostoses (HP:0100777)	1.62869098
88	Hypopigmentation of the fundus (HP:0007894)	1.62614009
89	Infertility (HP:0000789)	1.62265414
90	Paraplegia (HP:0010550)	1.61928859
91	Distal lower limb muscle weakness (HP:0009053)	1.59748888
92	Atelectasis (HP:0100750)	1.59082312
93	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.58798138
94	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.58798138
95	Spastic paraplegia (HP:0001258)	1.58271201
96	Abnormality of the phalanges of the hallux (HP:0010057)	1.57744244
97	Bell-shaped thorax (HP:0001591)	1.53855121
98	Trigonocephaly (HP:0000243)	1.53149212
99	Hypoalphalipoproteinemia (HP:0003233)	1.52732793
100	Premature rupture of membranes (HP:0001788)	1.52346189

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA3	3.63071103
2	CASK	3.23296288
3	PRKD3	3.13047197
4	ICK	3.10129300
5	MAP3K4	2.65646121
6	PRPF4B	2.59973344
7	MAP2K7	2.52914451
8	TRIB3	2.45254288
9	TESK1	2.30618020
10	KSR2	2.13927236
11	DDR2	2.10532156
12	DYRK1B	1.97587803
13	MAP2K4	1.79305106
14	TTN	1.74231508
15	PAK6	1.71705272
16	PDGFRA	1.69714429
17	SIK1	1.65137466
18	MARK1	1.62075073
19	BRD4	1.54933311
20	SCYL2	1.49852886
21	MAP3K6	1.40792063
22	PKN2	1.31426944
23	STK38	1.29769235
24	RIPK1	1.27944133
25	SIK2	1.25653060
26	NEK6	1.23615188
27	TAOK2	1.17379067
28	TRIM28	1.14529744
29	PDPK1	1.13137193
30	EPHA2	1.07507285
31	ARAF	1.05085629
32	MARK2	1.00199212
33	MAP4K2	0.97572884
34	CDK12	0.97330332
35	RPS6KA2	0.96961553
36	SIK3	0.95554858
37	KSR1	0.95207991
38	PRKD2	0.93508228
39	RAF1	0.92880660
40	UHMK1	0.92297111
41	NTRK2	0.92239022
42	PDK1	0.91733402
43	EEF2K	0.87002681
44	MST1R	0.84479276
45	CAMK2B	0.83914210
46	CAMK2G	0.83094465
47	ERN1	0.79159832
48	PLK4	0.77330753
49	RET	0.74710735
50	CDK5	0.72525675
51	PRKCH	0.70556670
52	RIPK4	0.70526791
53	MTOR	0.70455384
54	DAPK2	0.68543210
55	MOS	0.67853634
56	AKT3	0.67470043
57	LMTK2	0.67358916
58	MAP3K7	0.65427048
59	OBSCN	0.63129082
60	MAPK12	0.62502560
61	TAOK1	0.60732815
62	MAP3K10	0.60065554
63	RPS6KC1	0.59295338
64	RPS6KL1	0.59295338
65	PRKCZ	0.59097085
66	MAP3K11	0.58879404
67	EPHA4	0.58099815
68	NTRK1	0.55835870
69	EPHB1	0.53913526
70	GRK5	0.52701408
71	MAPK15	0.52190783
72	TESK2	0.52139508
73	BRAF	0.51467881
74	PRKD1	0.51145161
75	CAMKK1	0.48759735
76	PRKAA1	0.46340570
77	ERBB4	0.45251412
78	MET	0.45192979
79	WNK1	0.44558118
80	MAPK7	0.44318776
81	LATS2	0.44100178
82	MAP2K3	0.44085371
83	PHKG2	0.43919362
84	PHKG1	0.43919362
85	MAP2K1	0.43460462
86	PTK2B	0.42314562
87	SGK3	0.41959423
88	MAPKAPK3	0.41863844
89	FGFR4	0.41526068
90	PRKCG	0.41056060
91	NTRK3	0.40136403
92	CAMK4	0.40015359
93	CDK6	0.39624884
94	BLK	0.39315950
95	RPS6KA6	0.39143930
96	MAPK11	0.37926035
97	GRK6	0.37777959
98	DYRK1A	0.37663421
99	JAK2	0.36509331
100	CDC42BPA	0.35234319

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.57199276
2	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.76175591
3	Nicotine addiction_Homo sapiens_hsa05033	1.75770811
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60526778
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.57635552
6	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.48755352
7	GABAergic synapse_Homo sapiens_hsa04727	1.45398653
8	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.44273228
9	Morphine addiction_Homo sapiens_hsa05032	1.33435650
10	Long-term potentiation_Homo sapiens_hsa04720	1.31256116
11	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.28203528
12	Pancreatic secretion_Homo sapiens_hsa04972	1.24516021
13	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.24072805
14	Circadian entrainment_Homo sapiens_hsa04713	1.22230720
15	ErbB signaling pathway_Homo sapiens_hsa04012	1.18979865
16	Focal adhesion_Homo sapiens_hsa04510	1.18592222
17	Endocytosis_Homo sapiens_hsa04144	1.16794858
18	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.15230045
19	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.14403172
20	GnRH signaling pathway_Homo sapiens_hsa04912	1.14057953
21	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.12951062
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.10517468
23	Gap junction_Homo sapiens_hsa04540	1.07930767
24	cAMP signaling pathway_Homo sapiens_hsa04024	1.07912679
25	Insulin signaling pathway_Homo sapiens_hsa04910	1.06980400
26	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.05710152
27	Endometrial cancer_Homo sapiens_hsa05213	1.05424152
28	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.05403805
29	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.04508002
30	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.02624740
31	Choline metabolism in cancer_Homo sapiens_hsa05231	1.01667179
32	Melanogenesis_Homo sapiens_hsa04916	0.99725483
33	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.99673326
34	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.98805916
35	ECM-receptor interaction_Homo sapiens_hsa04512	0.98140406
36	Estrogen signaling pathway_Homo sapiens_hsa04915	0.98006816
37	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.97370185
38	Axon guidance_Homo sapiens_hsa04360	0.96780312
39	Gastric acid secretion_Homo sapiens_hsa04971	0.96237298
40	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.94925172
41	VEGF signaling pathway_Homo sapiens_hsa04370	0.93788409
42	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.93764080
43	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.93254670
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.92404020
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.91819998
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91469116
47	Tight junction_Homo sapiens_hsa04530	0.90125178
48	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.89490994
49	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.87170435
50	Type II diabetes mellitus_Homo sapiens_hsa04930	0.84403361
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.83928856
52	Platelet activation_Homo sapiens_hsa04611	0.82569968
53	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.82464996
54	Butanoate metabolism_Homo sapiens_hsa00650	0.82338772
55	Acute myeloid leukemia_Homo sapiens_hsa05221	0.82194860
56	Other glycan degradation_Homo sapiens_hsa00511	0.81631014
57	Renal cell carcinoma_Homo sapiens_hsa05211	0.81441653
58	Cholinergic synapse_Homo sapiens_hsa04725	0.80592303
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.80095993
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79332121
61	Protein digestion and absorption_Homo sapiens_hsa04974	0.79223321
62	Non-small cell lung cancer_Homo sapiens_hsa05223	0.79076406
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.78784733
64	Caffeine metabolism_Homo sapiens_hsa00232	0.78202311
65	Bile secretion_Homo sapiens_hsa04976	0.78151567
66	Long-term depression_Homo sapiens_hsa04730	0.77978532
67	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.77912243
68	Glioma_Homo sapiens_hsa05214	0.77454441
69	Amphetamine addiction_Homo sapiens_hsa05031	0.76187740
70	Insulin resistance_Homo sapiens_hsa04931	0.74115851
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.73286377
72	Prolactin signaling pathway_Homo sapiens_hsa04917	0.72373734
73	ABC transporters_Homo sapiens_hsa02010	0.72277388
74	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71591179
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.71430762
76	Notch signaling pathway_Homo sapiens_hsa04330	0.71304583
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.69079905
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.68368721
79	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.68175061
80	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.67820841
81	Pancreatic cancer_Homo sapiens_hsa05212	0.64689865
82	Taste transduction_Homo sapiens_hsa04742	0.63625929
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.63181440
84	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.62507046
85	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.62157853
86	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.61795630
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60674008
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60178363
89	Olfactory transduction_Homo sapiens_hsa04740	0.59885159
90	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.58832302
91	Cocaine addiction_Homo sapiens_hsa05030	0.58770678
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58381403
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57673973
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.57000696
95	Proteoglycans in cancer_Homo sapiens_hsa05205	0.56884280
96	Salivary secretion_Homo sapiens_hsa04970	0.55964687
97	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55946616
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55908509
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55586382
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.55126524

HSFX1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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