HSFX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycine transport (GO:0015816)5.01320433
2acrosome reaction (GO:0007340)4.34910460
3fusion of sperm to egg plasma membrane (GO:0007342)4.05262720
4microtubule severing (GO:0051013)4.01481146
5positive regulation of synapse maturation (GO:0090129)3.91977978
6sperm capacitation (GO:0048240)3.91218079
7sperm motility (GO:0030317)3.90320588
8regulation of synapse maturation (GO:0090128)3.78450087
9cellular ketone body metabolic process (GO:0046950)3.68011949
10synaptic vesicle exocytosis (GO:0016079)3.44724080
11growth hormone secretion (GO:0030252)3.40544715
12activation of protein kinase A activity (GO:0034199)3.38243780
13gamma-aminobutyric acid transport (GO:0015812)3.37268354
14regulation of ARF protein signal transduction (GO:0032012)3.26248200
15plasma membrane fusion (GO:0045026)3.24968316
16ketone body metabolic process (GO:1902224)3.19306632
17regulation of somitogenesis (GO:0014807)3.18717019
18neuronal ion channel clustering (GO:0045161)3.11142568
19response to pheromone (GO:0019236)3.10666489
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.07902074
21negative regulation of inclusion body assembly (GO:0090084)2.99944799
22cell-cell junction maintenance (GO:0045217)2.99870916
23positive regulation of insulin receptor signaling pathway (GO:0046628)2.99583973
24receptor recycling (GO:0001881)2.98850853
25retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98668750
26DNA topological change (GO:0006265)2.97553280
27regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.97146701
28positive regulation of Rab GTPase activity (GO:0032851)2.93797827
29regulation of Rab GTPase activity (GO:0032313)2.93797827
30protein targeting to Golgi (GO:0000042)2.93118312
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89422957
32positive regulation of cellular response to insulin stimulus (GO:1900078)2.88402093
33sexual reproduction (GO:0019953)2.84432784
34macroautophagy (GO:0016236)2.84214800
35regulation of glucose import in response to insulin stimulus (GO:2001273)2.84039963
36DNA integration (GO:0015074)2.82365857
37Golgi transport vesicle coating (GO:0048200)2.81000599
38COPI coating of Golgi vesicle (GO:0048205)2.81000599
39vocalization behavior (GO:0071625)2.73836620
40cardiac muscle hypertrophy in response to stress (GO:0014898)2.72822496
41muscle hypertrophy in response to stress (GO:0003299)2.72822496
42cardiac muscle adaptation (GO:0014887)2.72822496
43negative regulation of cell size (GO:0045792)2.72630795
44regulation of protein kinase A signaling (GO:0010738)2.69276582
45cell junction maintenance (GO:0034331)2.69235871
46calcium ion-dependent exocytosis (GO:0017156)2.68670885
47seminiferous tubule development (GO:0072520)2.64258540
48establishment of protein localization to Golgi (GO:0072600)2.63309025
49poly(A)+ mRNA export from nucleus (GO:0016973)2.62533465
50regulation of ARF GTPase activity (GO:0032312)2.62526538
51nerve growth factor signaling pathway (GO:0038180)2.58737835
52glomerular visceral epithelial cell development (GO:0072015)2.58536893
53spermatid development (GO:0007286)2.56463252
54leukotriene biosynthetic process (GO:0019370)2.55536565
55neuronal action potential propagation (GO:0019227)2.55491989
56regulation of NFAT protein import into nucleus (GO:0051532)2.54971377
57microtubule depolymerization (GO:0007019)2.53069124
58glomerular epithelial cell development (GO:0072310)2.52708675
59neurotransmitter-gated ion channel clustering (GO:0072578)2.51865606
60spermatid nucleus differentiation (GO:0007289)2.50672859
61RNA localization (GO:0006403)2.48894182
62establishment of apical/basal cell polarity (GO:0035089)2.46475330
63planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46441609
64chromosome condensation (GO:0030261)2.46104415
65cellular component maintenance (GO:0043954)2.45402141
66phosphatidylethanolamine biosynthetic process (GO:0006646)2.44886628
67reproduction (GO:0000003)2.42866950
68multicellular organism reproduction (GO:0032504)2.42280720
69protein retention in ER lumen (GO:0006621)2.40250044
70mitochondrial fusion (GO:0008053)2.39872017
71intracellular estrogen receptor signaling pathway (GO:0030520)2.34507969
72chromatin silencing (GO:0006342)2.34324758
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32915122
74negative regulation of actin filament depolymerization (GO:0030835)2.32784446
75stress fiber assembly (GO:0043149)2.32091967
76cell migration in hindbrain (GO:0021535)2.29590446
77neurotransmitter secretion (GO:0007269)2.29530370
78vesicle transport along microtubule (GO:0047496)2.28375426
79protein polyglutamylation (GO:0018095)2.27788828
80cardiac muscle hypertrophy (GO:0003300)2.26402061
81SMAD protein complex assembly (GO:0007183)2.26373285
82long-term memory (GO:0007616)2.24337409
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.23450792
84protein localization to endosome (GO:0036010)2.22611964
85barbed-end actin filament capping (GO:0051016)2.22453919
86peptidyl-proline hydroxylation (GO:0019511)2.22100043
87negative regulation of gene expression, epigenetic (GO:0045814)2.21877514
88striated muscle hypertrophy (GO:0014897)2.21230723
89protein localization to Golgi apparatus (GO:0034067)2.20890591
90myoblast fusion (GO:0007520)2.19472026
91syncytium formation by plasma membrane fusion (GO:0000768)2.19243400
92cellular response to nerve growth factor stimulus (GO:1990090)2.19092535
93response to nerve growth factor (GO:1990089)2.19092535
94neuron recognition (GO:0008038)2.18934506
95cilium or flagellum-dependent cell motility (GO:0001539)2.18721446
96cerebellar granule cell differentiation (GO:0021707)2.18644800
97nucleus organization (GO:0006997)2.18126467
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.17891893
99adherens junction assembly (GO:0034333)2.16818541
100DNA packaging (GO:0006323)2.16351249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.05370513
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02846965
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.69578663
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.55208026
5DROSHA_22980978_ChIP-Seq_HELA_Human2.54733557
6LXR_22292898_ChIP-Seq_THP-1_Human2.33240001
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30845414
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.27651392
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15017351
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03098394
11STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97093766
12KDM2B_26808549_Chip-Seq_K562_Human1.93120383
13CTCF_27219007_Chip-Seq_Bcells_Human1.90350646
14SMC4_20622854_ChIP-Seq_HELA_Human1.85917205
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77153356
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73093584
17EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72937189
18P68_20966046_ChIP-Seq_HELA_Human1.72339999
19DNAJC2_21179169_ChIP-ChIP_NT2_Human1.69299383
20KDM2B_26808549_Chip-Seq_DND41_Human1.68933213
21TP53_22127205_ChIP-Seq_IMR90_Human1.61867383
22SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60924395
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57130469
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53030555
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51697232
26TCF7_22412390_ChIP-Seq_EML_Mouse1.49705785
27EZH2_22144423_ChIP-Seq_EOC_Human1.49320449
28CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44404159
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.43901329
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.42859209
31TET1_21490601_ChIP-Seq_MESCs_Mouse1.41967668
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.37636095
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.37559571
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37482411
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35639265
36TP63_22573176_ChIP-Seq_HFKS_Human1.35575046
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33033585
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.32690294
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.32354238
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32149146
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31031226
42MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29662869
43RACK7_27058665_Chip-Seq_MCF-7_Human1.26941050
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26305463
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.25665535
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23878046
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23870070
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23239468
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.22983773
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.22927579
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20447461
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19029344
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18704089
54PHF8_20622854_ChIP-Seq_HELA_Human1.17013479
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.16429840
56BCOR_27268052_Chip-Seq_Bcells_Human1.15718236
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.14793840
58E2F1_20622854_ChIP-Seq_HELA_Human1.14719271
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.13461023
60GATA1_19941826_ChIP-Seq_K562_Human1.12968710
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11619311
62CREB1_26743006_Chip-Seq_LNCaP_Human1.10892531
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10581235
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10045863
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.09282996
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08195226
67OCT4_19829295_ChIP-Seq_ESCs_Human1.07588318
68SA1_27219007_Chip-Seq_Bcells_Human1.06825125
69RAC3_21632823_ChIP-Seq_H3396_Human1.06509178
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05803772
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05074242
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04902359
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04837629
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04345349
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01489028
76TP53_23651856_ChIP-Seq_MEFs_Mouse1.01030629
77BCL6_27268052_Chip-Seq_Bcells_Human1.00322324
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00149857
79KLF4_19829295_ChIP-Seq_ESCs_Human0.99700490
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99575234
81REST_18959480_ChIP-ChIP_MESCs_Mouse0.99216121
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.97634234
83EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97572053
84RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97572053
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97365892
86RNF2_27304074_Chip-Seq_ESCs_Mouse0.97031126
87RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96840835
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96440948
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96012550
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94646207
91CTCF_21964334_Chip-Seq_Bcells_Human0.94245137
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93660601
93EED_16625203_ChIP-ChIP_MESCs_Mouse0.93484149
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91989501
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91559844
96TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91071165
97TBX20_22328084_ChIP-Seq_HEART_Mouse0.90957650
98TBX20_22080862_ChIP-Seq_HEART_Mouse0.90957650
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89000456
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.88542562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.81299896
2MP0004859_abnormal_synaptic_plasticity4.39388593
3MP0000013_abnormal_adipose_tissue3.52862886
4MP0008995_early_reproductive_senescence3.38404860
5MP0005410_abnormal_fertilization3.37786993
6MP0001986_abnormal_taste_sensitivity3.28924257
7MP0009384_cardiac_valve_regurgitation3.25865432
8MP0001873_stomach_inflammation3.07540850
9MP0009840_abnormal_foam_cell2.72461531
10MP0005409_darkened_coat_color2.71195937
11MP0002735_abnormal_chemical_nociception2.61033573
12MP0008260_abnormal_autophagy2.39211189
13MP0005670_abnormal_white_adipose2.34851986
14MP0005451_abnormal_body_composition2.17969333
15MP0000751_myopathy2.06652234
16MP0000613_abnormal_salivary_gland1.93471079
17MP0001348_abnormal_lacrimal_gland1.84587810
18MP0000003_abnormal_adipose_tissue1.82460556
19MP0003279_aneurysm1.70770588
20MP0004270_analgesia1.59879676
21MP0004510_myositis1.58979236
22MP0003385_abnormal_body_wall1.57746643
23MP0003635_abnormal_synaptic_transmissio1.54600347
24MP0004233_abnormal_muscle_weight1.53618452
25MP0004858_abnormal_nervous_system1.53103340
26MP0001968_abnormal_touch/_nociception1.50482336
27MP0002249_abnormal_larynx_morphology1.49038078
28MP0000750_abnormal_muscle_regeneration1.47582530
29MP0000678_abnormal_parathyroid_gland1.42518496
30MP0003172_abnormal_lysosome_physiology1.41599792
31MP0001849_ear_inflammation1.40303070
32MP0003705_abnormal_hypodermis_morpholog1.39593009
33MP0005377_hearing/vestibular/ear_phenot1.36978725
34MP0003878_abnormal_ear_physiology1.36978725
35MP0005623_abnormal_meninges_morphology1.29490570
36MP0000733_abnormal_muscle_development1.27904993
37MP0005171_absent_coat_pigmentation1.25730784
38MP0003329_amyloid_beta_deposits1.24622799
39MP0005423_abnormal_somatic_nervous1.23435480
40MP0000759_abnormal_skeletal_muscle1.22815671
41MP0001958_emphysema1.20402693
42MP0005375_adipose_tissue_phenotype1.19336109
43MP0004272_abnormal_basement_membrane1.18360688
44MP0008438_abnormal_cutaneous_collagen1.08291398
45MP0003091_abnormal_cell_migration1.07782799
46MP0003698_abnormal_male_reproductive1.07176744
47MP0000681_abnormal_thyroid_gland1.04742491
48MP0000534_abnormal_ureter_morphology1.04055286
49MP0005248_abnormal_Harderian_gland1.03318180
50MP0001270_distended_abdomen0.99789847
51MP0002736_abnormal_nociception_after0.98934490
52MP0002877_abnormal_melanocyte_morpholog0.98549082
53MP0002127_abnormal_cardiovascular_syste0.92067481
54MP0002108_abnormal_muscle_morphology0.91275895
55MP0002269_muscular_atrophy0.90499964
56MP0005367_renal/urinary_system_phenotyp0.89869357
57MP0000516_abnormal_urinary_system0.89869357
58MP0005620_abnormal_muscle_contractility0.89137843
59MP0002063_abnormal_learning/memory/cond0.88271140
60MP0006138_congestive_heart_failure0.87883947
61MP0005076_abnormal_cell_differentiation0.85574857
62MP0004087_abnormal_muscle_fiber0.83952747
63MP0003828_pulmonary_edema0.82279711
64MP0004947_skin_inflammation0.82227698
65MP0003303_peritoneal_inflammation0.80774674
66MP0002733_abnormal_thermal_nociception0.80583836
67MP0005503_abnormal_tendon_morphology0.80139293
68MP0003935_abnormal_craniofacial_develop0.79192634
69MP0001502_abnormal_circadian_rhythm0.78505927
70MP0008874_decreased_physiological_sensi0.77580076
71MP0003566_abnormal_cell_adhesion0.77392678
72MP0004130_abnormal_muscle_cell0.76818294
73MP0004142_abnormal_muscle_tone0.76552422
74MP0003221_abnormal_cardiomyocyte_apopto0.76232148
75MP0001299_abnormal_eye_distance/0.73999059
76MP0003690_abnormal_glial_cell0.72734094
77MP0001929_abnormal_gametogenesis0.72467356
78MP0008569_lethality_at_weaning0.72349141
79MP0004036_abnormal_muscle_relaxation0.71410848
80MP0005369_muscle_phenotype0.70495565
81MP0002234_abnormal_pharynx_morphology0.69235898
82MP0002106_abnormal_muscle_physiology0.69036070
83MP0002896_abnormal_bone_mineralization0.68897469
84MP0004084_abnormal_cardiac_muscle0.68762847
85MP0002132_abnormal_respiratory_system0.68665252
86MP0002161_abnormal_fertility/fecundity0.68119536
87MP0001970_abnormal_pain_threshold0.67531149
88MP0005666_abnormal_adipose_tissue0.66521984
89MP0003137_abnormal_impulse_conducting0.66217503
90MP0000767_abnormal_smooth_muscle0.64008353
91MP0002972_abnormal_cardiac_muscle0.62188609
92MP0001175_abnormal_lung_morphology0.60542979
93MP0001486_abnormal_startle_reflex0.60070127
94MP0004811_abnormal_neuron_physiology0.59030906
95MP0000465_gastrointestinal_hemorrhage0.58776324
96MP0001664_abnormal_digestion0.57268839
97MP0005257_abnormal_intraocular_pressure0.55899109
98MP0000747_muscle_weakness0.55596571
99MP0000604_amyloidosis0.52887004
100MP0003634_abnormal_glial_cell0.52612698

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)4.84935708
2Termporal pattern (HP:0011008)4.07216533
3Insidious onset (HP:0003587)4.07216533
4Subaortic stenosis (HP:0001682)3.58661544
5Abnormality of the left ventricular outflow tract (HP:0011103)3.58661544
6Male infertility (HP:0003251)3.09912501
7Distal lower limb amyotrophy (HP:0008944)2.96784467
8Spastic gait (HP:0002064)2.94581522
9Ankle clonus (HP:0011448)2.83402703
10Hyperacusis (HP:0010780)2.80497528
11Lower limb amyotrophy (HP:0007210)2.68423116
12Asymmetric septal hypertrophy (HP:0001670)2.63323636
13Epidermoid cyst (HP:0200040)2.57683162
14Neoplasm of the heart (HP:0100544)2.56962086
15Obstructive sleep apnea (HP:0002870)2.52878778
16Exercise-induced myalgia (HP:0003738)2.52031176
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50315782
18Abnormality of the periventricular white matter (HP:0002518)2.44671708
19Hepatoblastoma (HP:0002884)2.43634289
20Hyperkalemia (HP:0002153)2.42128032
21Shallow orbits (HP:0000586)2.40648100
22Increased connective tissue (HP:0009025)2.36580686
23Renovascular hypertension (HP:0100817)2.35568415
24Centrally nucleated skeletal muscle fibers (HP:0003687)2.32940053
25Severe visual impairment (HP:0001141)2.32776989
26Lower limb muscle weakness (HP:0007340)2.24949977
27Intellectual disability, moderate (HP:0002342)2.22235537
28Progressive sensorineural hearing impairment (HP:0000408)2.20662297
29Distal upper limb amyotrophy (HP:0007149)2.18853413
30Upper limb amyotrophy (HP:0009129)2.18853413
31Myopathic facies (HP:0002058)2.18534580
32Increased variability in muscle fiber diameter (HP:0003557)2.16388280
33Mildly elevated creatine phosphokinase (HP:0008180)2.16207504
34Urinary bladder sphincter dysfunction (HP:0002839)2.11292933
35Chronic hepatic failure (HP:0100626)2.09243324
36Broad ribs (HP:0000885)2.08768868
37Spina bifida occulta (HP:0003298)2.05948712
38Aneurysm (HP:0002617)2.04679390
39Abnormality of the pubic bones (HP:0003172)2.04657447
40Broad face (HP:0000283)2.01211958
41Arterial tortuosity (HP:0005116)2.00814561
42Protrusio acetabuli (HP:0003179)1.96014715
43Hydroureter (HP:0000072)1.95662007
44Bowel incontinence (HP:0002607)1.92626750
45Type 1 muscle fiber predominance (HP:0003803)1.92259295
46Lymphangioma (HP:0100764)1.92210732
47Hand muscle atrophy (HP:0009130)1.92189006
48Vertebral clefting (HP:0008428)1.90848865
49Bundle branch block (HP:0011710)1.89017847
50Vascular tortuosity (HP:0004948)1.88926540
51Hemorrhage of the eye (HP:0011885)1.87835241
52Abnormality of skeletal muscle fiber size (HP:0012084)1.87044501
53Long toe (HP:0010511)1.86933449
54Rhizomelia (HP:0008905)1.86624708
55Ulnar bowing (HP:0003031)1.85498643
56Flat acetabular roof (HP:0003180)1.85215547
57Atrophic scars (HP:0001075)1.82410922
58Aplasia involving bones of the extremities (HP:0009825)1.82183600
59Aplasia involving bones of the upper limbs (HP:0009823)1.82183600
60Aplasia of the phalanges of the hand (HP:0009802)1.82183600
61Atrioventricular block (HP:0001678)1.81780028
62Back pain (HP:0003418)1.81249523
63Cervical subluxation (HP:0003308)1.81223929
64Open mouth (HP:0000194)1.80350187
65Abnormality of the aortic arch (HP:0012303)1.77341967
66Ventricular tachycardia (HP:0004756)1.76540477
67Cerebral aneurysm (HP:0004944)1.76387250
68Bladder diverticulum (HP:0000015)1.76253349
69Thin bony cortex (HP:0002753)1.76002150
70Papilledema (HP:0001085)1.75922455
71Long clavicles (HP:0000890)1.75916731
72Abnormal atrioventricular conduction (HP:0005150)1.75693379
73Absent speech (HP:0001344)1.75187437
74Abnormality of the corticospinal tract (HP:0002492)1.73358129
75Precocious puberty (HP:0000826)1.72811471
76Broad palm (HP:0001169)1.72495382
77Abnormal large intestine physiology (HP:0012700)1.71290034
78Heart block (HP:0012722)1.70667042
79Drooling (HP:0002307)1.66603888
80Nasal polyposis (HP:0100582)1.66071049
81Impaired vibration sensation in the lower limbs (HP:0002166)1.65953430
82Abnormality of the parathyroid morphology (HP:0011766)1.65622095
83Excessive salivation (HP:0003781)1.65439981
84Spinal canal stenosis (HP:0003416)1.64795053
85Complete atrioventricular canal defect (HP:0001674)1.64697996
86Deformed sella turcica (HP:0002681)1.64376557
87Exostoses (HP:0100777)1.62869098
88Hypopigmentation of the fundus (HP:0007894)1.62614009
89Infertility (HP:0000789)1.62265414
90Paraplegia (HP:0010550)1.61928859
91Distal lower limb muscle weakness (HP:0009053)1.59748888
92Atelectasis (HP:0100750)1.59082312
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.58798138
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58798138
95Spastic paraplegia (HP:0001258)1.58271201
96Abnormality of the phalanges of the hallux (HP:0010057)1.57744244
97Bell-shaped thorax (HP:0001591)1.53855121
98Trigonocephaly (HP:0000243)1.53149212
99Hypoalphalipoproteinemia (HP:0003233)1.52732793
100Premature rupture of membranes (HP:0001788)1.52346189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA33.63071103
2CASK3.23296288
3PRKD33.13047197
4ICK3.10129300
5MAP3K42.65646121
6PRPF4B2.59973344
7MAP2K72.52914451
8TRIB32.45254288
9TESK12.30618020
10KSR22.13927236
11DDR22.10532156
12DYRK1B1.97587803
13MAP2K41.79305106
14TTN1.74231508
15PAK61.71705272
16PDGFRA1.69714429
17SIK11.65137466
18MARK11.62075073
19BRD41.54933311
20SCYL21.49852886
21MAP3K61.40792063
22PKN21.31426944
23STK381.29769235
24RIPK11.27944133
25SIK21.25653060
26NEK61.23615188
27TAOK21.17379067
28TRIM281.14529744
29PDPK11.13137193
30EPHA21.07507285
31ARAF1.05085629
32MARK21.00199212
33MAP4K20.97572884
34CDK120.97330332
35RPS6KA20.96961553
36SIK30.95554858
37KSR10.95207991
38PRKD20.93508228
39RAF10.92880660
40UHMK10.92297111
41NTRK20.92239022
42PDK10.91733402
43EEF2K0.87002681
44MST1R0.84479276
45CAMK2B0.83914210
46CAMK2G0.83094465
47ERN10.79159832
48PLK40.77330753
49RET0.74710735
50CDK50.72525675
51PRKCH0.70556670
52RIPK40.70526791
53MTOR0.70455384
54DAPK20.68543210
55MOS0.67853634
56AKT30.67470043
57LMTK20.67358916
58MAP3K70.65427048
59OBSCN0.63129082
60MAPK120.62502560
61TAOK10.60732815
62MAP3K100.60065554
63RPS6KC10.59295338
64RPS6KL10.59295338
65PRKCZ0.59097085
66MAP3K110.58879404
67EPHA40.58099815
68NTRK10.55835870
69EPHB10.53913526
70GRK50.52701408
71MAPK150.52190783
72TESK20.52139508
73BRAF0.51467881
74PRKD10.51145161
75CAMKK10.48759735
76PRKAA10.46340570
77ERBB40.45251412
78MET0.45192979
79WNK10.44558118
80MAPK70.44318776
81LATS20.44100178
82MAP2K30.44085371
83PHKG20.43919362
84PHKG10.43919362
85MAP2K10.43460462
86PTK2B0.42314562
87SGK30.41959423
88MAPKAPK30.41863844
89FGFR40.41526068
90PRKCG0.41056060
91NTRK30.40136403
92CAMK40.40015359
93CDK60.39624884
94BLK0.39315950
95RPS6KA60.39143930
96MAPK110.37926035
97GRK60.37777959
98DYRK1A0.37663421
99JAK20.36509331
100CDC42BPA0.35234319

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57199276
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76175591
3Nicotine addiction_Homo sapiens_hsa050331.75770811
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60526778
5Synaptic vesicle cycle_Homo sapiens_hsa047211.57635552
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48755352
7GABAergic synapse_Homo sapiens_hsa047271.45398653
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44273228
9Morphine addiction_Homo sapiens_hsa050321.33435650
10Long-term potentiation_Homo sapiens_hsa047201.31256116
11Dilated cardiomyopathy_Homo sapiens_hsa054141.28203528
12Pancreatic secretion_Homo sapiens_hsa049721.24516021
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24072805
14Circadian entrainment_Homo sapiens_hsa047131.22230720
15ErbB signaling pathway_Homo sapiens_hsa040121.18979865
16Focal adhesion_Homo sapiens_hsa045101.18592222
17Endocytosis_Homo sapiens_hsa041441.16794858
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.15230045
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14403172
20GnRH signaling pathway_Homo sapiens_hsa049121.14057953
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12951062
22Sphingolipid metabolism_Homo sapiens_hsa006001.10517468
23Gap junction_Homo sapiens_hsa045401.07930767
24cAMP signaling pathway_Homo sapiens_hsa040241.07912679
25Insulin signaling pathway_Homo sapiens_hsa049101.06980400
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05710152
27Endometrial cancer_Homo sapiens_hsa052131.05424152
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.05403805
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.04508002
30Inositol phosphate metabolism_Homo sapiens_hsa005621.02624740
31Choline metabolism in cancer_Homo sapiens_hsa052311.01667179
32Melanogenesis_Homo sapiens_hsa049160.99725483
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99673326
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98805916
35ECM-receptor interaction_Homo sapiens_hsa045120.98140406
36Estrogen signaling pathway_Homo sapiens_hsa049150.98006816
37Sphingolipid signaling pathway_Homo sapiens_hsa040710.97370185
38Axon guidance_Homo sapiens_hsa043600.96780312
39Gastric acid secretion_Homo sapiens_hsa049710.96237298
40Glycosaminoglycan degradation_Homo sapiens_hsa005310.94925172
41VEGF signaling pathway_Homo sapiens_hsa043700.93788409
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93764080
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93254670
44Fatty acid biosynthesis_Homo sapiens_hsa000610.92404020
45Glutamatergic synapse_Homo sapiens_hsa047240.91819998
46Dorso-ventral axis formation_Homo sapiens_hsa043200.91469116
47Tight junction_Homo sapiens_hsa045300.90125178
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89490994
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.87170435
50Type II diabetes mellitus_Homo sapiens_hsa049300.84403361
51Glycerolipid metabolism_Homo sapiens_hsa005610.83928856
52Platelet activation_Homo sapiens_hsa046110.82569968
53Chronic myeloid leukemia_Homo sapiens_hsa052200.82464996
54Butanoate metabolism_Homo sapiens_hsa006500.82338772
55Acute myeloid leukemia_Homo sapiens_hsa052210.82194860
56Other glycan degradation_Homo sapiens_hsa005110.81631014
57Renal cell carcinoma_Homo sapiens_hsa052110.81441653
58Cholinergic synapse_Homo sapiens_hsa047250.80592303
59Dopaminergic synapse_Homo sapiens_hsa047280.80095993
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79332121
61Protein digestion and absorption_Homo sapiens_hsa049740.79223321
62Non-small cell lung cancer_Homo sapiens_hsa052230.79076406
63Fructose and mannose metabolism_Homo sapiens_hsa000510.78784733
64Caffeine metabolism_Homo sapiens_hsa002320.78202311
65Bile secretion_Homo sapiens_hsa049760.78151567
66Long-term depression_Homo sapiens_hsa047300.77978532
67Oxytocin signaling pathway_Homo sapiens_hsa049210.77912243
68Glioma_Homo sapiens_hsa052140.77454441
69Amphetamine addiction_Homo sapiens_hsa050310.76187740
70Insulin resistance_Homo sapiens_hsa049310.74115851
71mTOR signaling pathway_Homo sapiens_hsa041500.73286377
72Prolactin signaling pathway_Homo sapiens_hsa049170.72373734
73ABC transporters_Homo sapiens_hsa020100.72277388
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71591179
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71430762
76Notch signaling pathway_Homo sapiens_hsa043300.71304583
77Calcium signaling pathway_Homo sapiens_hsa040200.69079905
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68368721
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68175061
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.67820841
81Pancreatic cancer_Homo sapiens_hsa052120.64689865
82Taste transduction_Homo sapiens_hsa047420.63625929
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.63181440
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62507046
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62157853
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.61795630
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60674008
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60178363
89Olfactory transduction_Homo sapiens_hsa047400.59885159
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58832302
91Cocaine addiction_Homo sapiens_hsa050300.58770678
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58381403
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.57673973
94Hippo signaling pathway_Homo sapiens_hsa043900.57000696
95Proteoglycans in cancer_Homo sapiens_hsa052050.56884280
96Salivary secretion_Homo sapiens_hsa049700.55964687
97Rap1 signaling pathway_Homo sapiens_hsa040150.55946616
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55908509
99Hedgehog signaling pathway_Homo sapiens_hsa043400.55586382
100AMPK signaling pathway_Homo sapiens_hsa041520.55126524

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