HSFX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)8.48540143
2positive regulation of male gonad development (GO:2000020)8.01485899
3parturition (GO:0007567)6.84407837
4regulation of female gonad development (GO:2000194)6.55671309
5skeletal muscle organ development (GO:0060538)6.43510003
6negative regulation of metanephros development (GO:0072217)6.42519062
7regulation of male gonad development (GO:2000018)6.26215057
8diaphragm development (GO:0060539)6.13092640
9metanephric mesenchyme development (GO:0072075)6.08348368
10cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.88537582
11cellular response to gonadotropin stimulus (GO:0071371)5.74575768
12negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.63415947
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.59416538
14protein prenylation (GO:0018342)5.50844039
15prenylation (GO:0097354)5.50844039
16atrioventricular valve morphogenesis (GO:0003181)5.45478439
17short-term memory (GO:0007614)5.39822378
18glomerulus development (GO:0032835)5.28590805
19epithelial cell fate commitment (GO:0072148)5.21266320
20fusion of sperm to egg plasma membrane (GO:0007342)5.17004298
21negative regulation of macrophage differentiation (GO:0045650)5.15166887
22kidney mesenchyme development (GO:0072074)5.12719222
23endocardial cushion development (GO:0003197)4.95404134
24mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.90629881
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.90629881
26epithelial cilium movement (GO:0003351)4.87306221
27regulation of cell proliferation involved in kidney development (GO:1901722)4.82881064
28mesonephros development (GO:0001823)4.72849672
29muscle cell fate commitment (GO:0042693)4.67509039
30regulation of glomerulus development (GO:0090192)4.66873333
31cardiac right ventricle morphogenesis (GO:0003215)4.61077453
32epithelial cell differentiation involved in kidney development (GO:0035850)4.57957809
33mitochondrion transport along microtubule (GO:0047497)4.48860165
34establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.48860165
35regulation of mesenchymal cell apoptotic process (GO:2001053)4.48633635
36response to follicle-stimulating hormone (GO:0032354)4.46583750
37regulation of gonadotropin secretion (GO:0032276)4.46540037
38sex determination (GO:0007530)4.32404692
39establishment of mitochondrion localization (GO:0051654)4.32346253
40positive regulation of heart growth (GO:0060421)4.30393524
41somatic diversification of immune receptors via somatic mutation (GO:0002566)4.17856388
42somatic hypermutation of immunoglobulin genes (GO:0016446)4.17856388
43response to gonadotropin (GO:0034698)4.06491937
44muscle hypertrophy in response to stress (GO:0003299)4.05809935
45cardiac muscle adaptation (GO:0014887)4.05809935
46cardiac muscle hypertrophy in response to stress (GO:0014898)4.05809935
47metanephric epithelium development (GO:0072207)4.03739993
48glomerular basement membrane development (GO:0032836)4.03621153
49regulation of cardioblast differentiation (GO:0051890)4.03544283
50cilium or flagellum-dependent cell motility (GO:0001539)3.90307419
51resolution of meiotic recombination intermediates (GO:0000712)3.89512623
52positive regulation of mitochondrial membrane permeability (GO:0035794)3.86301478
53plasma membrane fusion (GO:0045026)3.82592283
54response to pheromone (GO:0019236)3.81466528
55single strand break repair (GO:0000012)3.81106078
56mesenchymal to epithelial transition (GO:0060231)3.69561206
57cilium movement (GO:0003341)3.64251592
58ventricular septum development (GO:0003281)3.58363965
59sulfur amino acid catabolic process (GO:0000098)3.56486079
60spermatid development (GO:0007286)3.52751283
61positive regulation of metanephros development (GO:0072216)3.50264583
62atrial septum morphogenesis (GO:0060413)3.47032842
63embryonic foregut morphogenesis (GO:0048617)3.46855912
64myelin assembly (GO:0032288)3.45691057
65head development (GO:0060322)3.35794364
66regulation of cardiac muscle cell contraction (GO:0086004)3.35708500
67male genitalia development (GO:0030539)3.32371158
68sperm motility (GO:0030317)3.29274036
69negative regulation of kidney development (GO:0090185)3.27214871
70purine ribonucleotide transport (GO:0015868)3.23649375
71endoderm formation (GO:0001706)3.22516237
72base-excision repair, AP site formation (GO:0006285)3.18854123
73microtubule depolymerization (GO:0007019)3.15511449
74reproductive system development (GO:0061458)3.15477585
75positive regulation of neurological system process (GO:0031646)3.15249714
76acrosome reaction (GO:0007340)3.11344467
77anatomical structure regression (GO:0060033)3.07023234
78SMAD protein signal transduction (GO:0060395)3.06800999
79positive regulation of mesonephros development (GO:0061213)3.06539177
80cell-cell junction maintenance (GO:0045217)3.06435777
81somite development (GO:0061053)3.03632283
82sensory perception of smell (GO:0007608)3.01742060
83otic vesicle formation (GO:0030916)3.00386936
84positive regulation of guanylate cyclase activity (GO:0031284)2.98245932
85cardiac muscle hypertrophy (GO:0003300)2.89233295
86sex differentiation (GO:0007548)2.89217657
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88485487
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88485487
89positive regulation of organ growth (GO:0046622)2.87340280
90gastrulation with mouth forming second (GO:0001702)2.83003197
91piRNA metabolic process (GO:0034587)2.82691899
92calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76102428
93cardiac septum development (GO:0003279)2.76020613
94regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.75702047
95chemosensory behavior (GO:0007635)2.74311618
96microtubule severing (GO:0051013)2.72491710
97striated muscle hypertrophy (GO:0014897)2.72011357
98cellular ketone body metabolic process (GO:0046950)2.71664111
99microtubule polymerization or depolymerization (GO:0031109)2.70672958
100epithelial cell maturation (GO:0002070)2.68880223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.79067383
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32506437
3GATA1_26923725_Chip-Seq_HPCs_Mouse2.81535536
4ZNF274_21170338_ChIP-Seq_K562_Hela2.66088096
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.46819722
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39067755
7IGF1R_20145208_ChIP-Seq_DFB_Human2.32917130
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.16194984
9EZH2_22144423_ChIP-Seq_EOC_Human2.12689029
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08343634
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07827074
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02961726
13UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84430167
14CTCF_27219007_Chip-Seq_Bcells_Human1.81742555
15PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.70794692
16MYC_18940864_ChIP-ChIP_HL60_Human1.68247591
17ETV2_25802403_ChIP-Seq_MESCs_Mouse1.66518994
18RNF2_27304074_Chip-Seq_NSC_Mouse1.66434267
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.66065097
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.65115784
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60460141
22HTT_18923047_ChIP-ChIP_STHdh_Human1.58906922
23CBP_20019798_ChIP-Seq_JUKART_Human1.57887349
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57887349
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57628854
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57128750
27AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53567042
28TBL1_22424771_ChIP-Seq_293T_Human1.52663844
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46189236
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45328972
31EWS_26573619_Chip-Seq_HEK293_Human1.44472656
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42624288
33CBP_21632823_ChIP-Seq_H3396_Human1.42568149
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41029809
35ERA_21632823_ChIP-Seq_H3396_Human1.40820203
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.40762593
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40132503
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38882041
39PHF8_20622853_ChIP-Seq_HELA_Human1.38118261
40HNFA_21074721_ChIP-Seq_CACO-2_Human1.36854005
41TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35623198
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34777951
43GBX2_23144817_ChIP-Seq_PC3_Human1.34300396
44GATA6_21074721_ChIP-Seq_CACO-2_Human1.33487559
45NFYB_21822215_ChIP-Seq_K562_Human1.33027815
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.31095191
47EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31060738
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30579764
49NANOG_20526341_ChIP-Seq_ESCs_Human1.29530901
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28549033
51NFYA_21822215_ChIP-Seq_K562_Human1.27002148
52* OCT4_20526341_ChIP-Seq_ESCs_Human1.22278256
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22159180
54ER_23166858_ChIP-Seq_MCF-7_Human1.19767802
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19731825
56E2F1_17053090_ChIP-ChIP_MCF-7_Human1.16667450
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15681209
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.15663577
59P53_21459846_ChIP-Seq_SAOS-2_Human1.15439300
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14388790
61* BCL6_27268052_Chip-Seq_Bcells_Human1.13822889
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12838287
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.12019520
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12009963
65CIITA_25753668_ChIP-Seq_RAJI_Human1.11963766
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09837696
67NCOR_22424771_ChIP-Seq_293T_Human1.09820443
68RXR_22108803_ChIP-Seq_LS180_Human1.09664310
69SA1_27219007_Chip-Seq_Bcells_Human1.09031286
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08901402
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07879556
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07707672
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06916308
74NANOG_19829295_ChIP-Seq_ESCs_Human1.06204053
75SOX2_19829295_ChIP-Seq_ESCs_Human1.06204053
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05891118
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05820425
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04939336
79HOXB7_26014856_ChIP-Seq_BT474_Human1.04154627
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.03175687
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02943198
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00116428
83* BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.99238384
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.98220917
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98220917
86TAL1_26923725_Chip-Seq_HPCs_Mouse0.97804594
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97496080
88BCAT_22108803_ChIP-Seq_LS180_Human0.97395639
89FOXH1_21741376_ChIP-Seq_ESCs_Human0.97243385
90DROSHA_22980978_ChIP-Seq_HELA_Human0.96830785
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.95800630
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95708390
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94399452
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.93516328
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93435550
96* PHF8_20622854_ChIP-Seq_HELA_Human0.93327657
97TP53_22573176_ChIP-Seq_HFKS_Human0.92780420
98RUNX2_22187159_ChIP-Seq_PCA_Human0.92751273
99AR_25329375_ChIP-Seq_VCAP_Human0.92434453
100MYC_19829295_ChIP-Seq_ESCs_Human0.89356690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.38931211
2MP0009384_cardiac_valve_regurgitation4.02051574
3MP0003880_abnormal_central_pattern3.61870571
4MP0005410_abnormal_fertilization3.45669161
5MP0006292_abnormal_olfactory_placode3.33821573
6MP0003828_pulmonary_edema2.87065749
7MP0001485_abnormal_pinna_reflex2.78363455
8MP0004133_heterotaxia2.77331498
9MP0008995_early_reproductive_senescence2.70419490
10MP0003787_abnormal_imprinting2.59348045
11MP0002102_abnormal_ear_morphology2.58810556
12MP0005423_abnormal_somatic_nervous2.56880117
13MP0002837_dystrophic_cardiac_calcinosis2.41244127
14MP0004142_abnormal_muscle_tone2.20408319
15MP0004885_abnormal_endolymph2.15466167
16MP0010386_abnormal_urinary_bladder2.03308273
17MP0002132_abnormal_respiratory_system2.02090322
18MP0001661_extended_life_span1.91182927
19MP0003221_abnormal_cardiomyocyte_apopto1.87256648
20MP0006276_abnormal_autonomic_nervous1.87004384
21MP0003315_abnormal_perineum_morphology1.84981005
22MP0006138_congestive_heart_failure1.84444917
23MP0000013_abnormal_adipose_tissue1.83111291
24MP0003011_delayed_dark_adaptation1.78366286
25MP0000049_abnormal_middle_ear1.74979236
26MP0003646_muscle_fatigue1.72119184
27MP0005389_reproductive_system_phenotype1.69106175
28MP0001919_abnormal_reproductive_system1.64610664
29MP0003942_abnormal_urinary_system1.64111979
30MP0008775_abnormal_heart_ventricle1.61936050
31MP0000383_abnormal_hair_follicle1.61334092
32MP0002127_abnormal_cardiovascular_syste1.57974625
33MP0002938_white_spotting1.55812023
34MP0003698_abnormal_male_reproductive1.53105462
35MP0001986_abnormal_taste_sensitivity1.50026601
36MP0003115_abnormal_respiratory_system1.49401806
37MP0000639_abnormal_adrenal_gland1.44655108
38MP0001929_abnormal_gametogenesis1.44474414
39MP0005551_abnormal_eye_electrophysiolog1.43028916
40MP0004859_abnormal_synaptic_plasticity1.38071282
41MP0008789_abnormal_olfactory_epithelium1.37963980
42MP0002210_abnormal_sex_determination1.37582158
43MP0001145_abnormal_male_reproductive1.27389929
44MP0000230_abnormal_systemic_arterial1.27026206
45MP0001764_abnormal_homeostasis1.26959166
46MP0002735_abnormal_chemical_nociception1.25715588
47MP0005646_abnormal_pituitary_gland1.24626067
48MP0000653_abnormal_sex_gland1.23280937
49MP0008058_abnormal_DNA_repair1.22705362
50MP0001486_abnormal_startle_reflex1.20871673
51MP0003567_abnormal_fetal_cardiomyocyte1.15605553
52MP0001968_abnormal_touch/_nociception1.14999064
53MP0005394_taste/olfaction_phenotype1.14344492
54MP0005499_abnormal_olfactory_system1.14344492
55MP0002928_abnormal_bile_duct1.13826289
56MP0005310_abnormal_salivary_gland1.13594817
57MP0000678_abnormal_parathyroid_gland1.13458418
58MP0003119_abnormal_digestive_system1.01762285
59MP0002229_neurodegeneration1.00764236
60MP0008875_abnormal_xenobiotic_pharmacok0.99663459
61MP0003136_yellow_coat_color0.98626745
62MP0003938_abnormal_ear_development0.96683844
63MP0002272_abnormal_nervous_system0.96058459
64MP0008872_abnormal_physiological_respon0.95811063
65MP0003122_maternal_imprinting0.95729913
66MP0004742_abnormal_vestibular_system0.95191323
67MP0000778_abnormal_nervous_system0.94038692
68MP0003943_abnormal_hepatobiliary_system0.91285354
69MP0002733_abnormal_thermal_nociception0.90743766
70MP0004215_abnormal_myocardial_fiber0.90381225
71MP0000631_abnormal_neuroendocrine_gland0.90331114
72MP0002160_abnormal_reproductive_system0.85836747
73MP0004811_abnormal_neuron_physiology0.85495174
74MP0002161_abnormal_fertility/fecundity0.84770472
75MP0000026_abnormal_inner_ear0.84174885
76MP0004484_altered_response_of0.79876070
77MP0003121_genomic_imprinting0.78715864
78MP0002909_abnormal_adrenal_gland0.78614803
79MP0009745_abnormal_behavioral_response0.76372392
80MP0003936_abnormal_reproductive_system0.75913565
81MP0009046_muscle_twitch0.74559991
82MP0001119_abnormal_female_reproductive0.74080070
83MP0001529_abnormal_vocalization0.72963999
84MP0005266_abnormal_metabolism0.71672678
85MP0000358_abnormal_cell_content/0.71070407
86MP0004145_abnormal_muscle_electrophysio0.68868636
87MP0002084_abnormal_developmental_patter0.66696497
88MP0006036_abnormal_mitochondrial_physio0.66114019
89MP0005620_abnormal_muscle_contractility0.63731519
90MP0001286_abnormal_eye_development0.63294501
91MP0000538_abnormal_urinary_bladder0.62523681
92MP0002752_abnormal_somatic_nervous0.62475369
93MP0002882_abnormal_neuron_morphology0.61875364
94MP0009333_abnormal_splenocyte_physiolog0.61794273
95MP0001963_abnormal_hearing_physiology0.60823348
96MP0005376_homeostasis/metabolism_phenot0.60771590
97MP0002152_abnormal_brain_morphology0.60726776
98MP0001849_ear_inflammation0.60555639
99MP0003786_premature_aging0.60505575
100MP0002063_abnormal_learning/memory/cond0.59591094

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)8.53932121
2Testicular neoplasm (HP:0010788)7.14133073
3Anomalous pulmonary venous return (HP:0010772)6.64931926
4Mesangial abnormality (HP:0001966)6.14653647
5Hypoplastic left heart (HP:0004383)6.02730945
6Abnormality of the pulmonary veins (HP:0011718)5.75290834
7True hermaphroditism (HP:0010459)5.39728889
8Hypoplastic heart (HP:0001961)4.99530479
9Abnormal ventriculo-arterial connection (HP:0011563)4.56607180
10Transposition of the great arteries (HP:0001669)4.56607180
11Abnormal connection of the cardiac segments (HP:0011545)4.56607180
12Abnormal sex determination (HP:0012244)4.55781545
13Sex reversal (HP:0012245)4.55781545
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.50352307
15Degeneration of the lateral corticospinal tracts (HP:0002314)4.50352307
16Germ cell neoplasia (HP:0100728)4.38454263
17Chronic hepatic failure (HP:0100626)4.36640068
18Male pseudohermaphroditism (HP:0000037)4.18897617
19Abnormal lung lobation (HP:0002101)3.70443188
20Abnormality of the corticospinal tract (HP:0002492)3.56630922
21Male infertility (HP:0003251)3.27829562
22Nephroblastoma (Wilms tumor) (HP:0002667)3.21781823
23Volvulus (HP:0002580)2.99583931
24Embryonal renal neoplasm (HP:0011794)2.96814185
25Impaired vibration sensation in the lower limbs (HP:0002166)2.93431084
26Female pseudohermaphroditism (HP:0010458)2.72407107
27Pancreatic fibrosis (HP:0100732)2.69447393
28Flat capital femoral epiphysis (HP:0003370)2.66284998
29Molar tooth sign on MRI (HP:0002419)2.59729948
30Abnormality of midbrain morphology (HP:0002418)2.59729948
31Truncal obesity (HP:0001956)2.56693653
32Abnormality of incisor morphology (HP:0011063)2.47870245
33Ovarian neoplasm (HP:0100615)2.40645908
34Preauricular pit (HP:0004467)2.38506163
35Periauricular skin pits (HP:0100277)2.38506163
36Amyotrophic lateral sclerosis (HP:0007354)2.38084462
37Retinal dysplasia (HP:0007973)2.35405375
38Nephronophthisis (HP:0000090)2.33175085
39Hypoplasia of the uterus (HP:0000013)2.32611899
40Primary adrenal insufficiency (HP:0008207)2.31538545
41Hand muscle atrophy (HP:0009130)2.30684173
42Urinary bladder sphincter dysfunction (HP:0002839)2.29121966
43Abnormality of the lower motor neuron (HP:0002366)2.28736106
44Focal segmental glomerulosclerosis (HP:0000097)2.24721286
45Preaxial foot polydactyly (HP:0001841)2.20508613
46Abnormality of DNA repair (HP:0003254)2.19026749
47Rib fusion (HP:0000902)2.18368567
48Flattened epiphyses (HP:0003071)2.12931434
49Pancreatic cysts (HP:0001737)2.07951032
50Type II lissencephaly (HP:0007260)2.02483201
51Embryonal neoplasm (HP:0002898)2.01965644
52Abnormality of male internal genitalia (HP:0000022)2.01733822
53Hyperlipoproteinemia (HP:0010980)1.98625329
54Irregular vertebral endplates (HP:0003301)1.98323535
55Stage 5 chronic kidney disease (HP:0003774)1.97474513
56Abnormality of the incisor (HP:0000676)1.96577142
57Urinary urgency (HP:0000012)1.94007284
58Abnormality of the vocal cords (HP:0008777)1.88607370
59Upper motor neuron abnormality (HP:0002127)1.87904411
60Proximal placement of thumb (HP:0009623)1.86219119
61Hyperventilation (HP:0002883)1.85244139
62Congenital stationary night blindness (HP:0007642)1.84125684
63Glomerulosclerosis (HP:0000096)1.83644210
64Rhabdomyosarcoma (HP:0002859)1.83356040
65Aplasia/hypoplasia of the uterus (HP:0008684)1.82537029
66Deviation of the thumb (HP:0009603)1.82188756
67Osteomalacia (HP:0002749)1.78148652
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.78080552
69Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76337787
70Abnormal biliary tract physiology (HP:0012439)1.75830762
71Bile duct proliferation (HP:0001408)1.75830762
72Optic nerve hypoplasia (HP:0000609)1.73402435
73Growth hormone deficiency (HP:0000824)1.71451822
74Hydroureter (HP:0000072)1.71027693
75Abnormal number of incisors (HP:0011064)1.70462349
76Congenital diaphragmatic hernia (HP:0000776)1.69340102
77Abnormality of the renal medulla (HP:0100957)1.69317483
78Abnormality of the peritoneum (HP:0002585)1.68961255
79Urethral obstruction (HP:0000796)1.67535531
80Chromsome breakage (HP:0040012)1.67233096
81Abnormality of dental color (HP:0011073)1.66907155
82Medulloblastoma (HP:0002885)1.65515933
83Vacuolated lymphocytes (HP:0001922)1.64991154
84Epidermoid cyst (HP:0200040)1.64399390
85Spastic gait (HP:0002064)1.64010785
86Upper limb amyotrophy (HP:0009129)1.63651377
87Distal upper limb amyotrophy (HP:0007149)1.63651377
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.63448497
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63443339
90Infertility (HP:0000789)1.63330382
91Renal cortical cysts (HP:0000803)1.60801770
92Neoplasm of striated muscle (HP:0009728)1.58874139
93Tetralogy of Fallot (HP:0001636)1.57933461
94Narrow forehead (HP:0000341)1.57455248
95Hyperthyroidism (HP:0000836)1.57132741
96Optic nerve coloboma (HP:0000588)1.56487871
97Absent/shortened dynein arms (HP:0200106)1.56265644
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.56265644
99Skin pits (HP:0100276)1.55055207
100Sclerocornea (HP:0000647)1.54527575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K28.32171999
2TRIM285.04134906
3SIK33.16169153
4CDK192.64065795
5PDK22.40652723
6PLK42.26755231
7NUAK12.17959850
8PINK12.08212461
9CCNB11.88321449
10CDK41.87622739
11MINK11.84375322
12NTRK31.66494737
13SIK21.64587639
14EPHB21.62420967
15TNK21.51707857
16WNK31.49361063
17PLK21.24704985
18PRKD21.23524146
19WNK41.18242684
20MAP3K41.17833765
21NLK1.16742524
22DYRK21.13336518
23PAK11.12997497
24EPHA41.12271347
25MAP2K71.07811928
26MARK21.07697231
27OXSR11.05820175
28BCKDK1.04175195
29PNCK1.02417556
30MAPK130.99186352
31DYRK1A0.98251931
32NTRK20.97327576
33RIPK40.95810284
34MAPK120.95519241
35PRKCG0.92204539
36CSNK1G10.89536863
37MAP3K70.86118176
38BCR0.85888281
39GRK10.85778809
40MARK30.85166056
41MAP2K40.83720561
42PAK30.82238720
43SGK2230.80030804
44SGK4940.80030804
45SGK10.79874238
46MAP3K60.74393244
47CAMK1G0.73279908
48STK160.68982993
49ADRBK20.68140772
50SGK20.67793910
51MAP3K50.67446044
52PRKAA20.66602196
53FRK0.66600070
54NEK60.65261114
55PRKCZ0.64239165
56PRKACG0.61843313
57INSRR0.61256778
58MELK0.59633708
59PHKG10.58032480
60PHKG20.58032480
61IKBKE0.56827509
62CHEK10.56238380
63ADRBK10.56123621
64SGK30.56052765
65ACVR1B0.55944270
66PRKACA0.55503657
67CDC70.52957084
68SRPK10.49174669
69MAP3K10.48793419
70AURKA0.48206703
71CAMK10.46879097
72PRKG10.46409836
73RPS6KA30.46340431
74CHEK20.45635892
75PLK10.45263273
76MAP3K110.45092869
77CSNK1G30.45067720
78MARK10.43081424
79STK380.42968834
80CDK11A0.41966539
81PTK60.41925405
82PKN10.41895126
83RPS6KA60.41338028
84MYLK0.41042517
85MAPK100.40246668
86MAP3K120.40131956
87RPS6KA10.39772307
88CDK10.37688720
89MAPK90.37580177
90PRKCI0.37312508
91DYRK1B0.36478868
92TEC0.35701526
93TIE10.35402467
94CDK50.34619070
95PRKACB0.34495328
96BMPR1B0.33601287
97GSK3B0.33094461
98PRKCA0.32526710
99MAP2K20.32361373
100PRKCE0.31814996

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.80406448
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.31277244
3Hedgehog signaling pathway_Homo sapiens_hsa043402.95697457
4Phototransduction_Homo sapiens_hsa047442.81723067
5Fanconi anemia pathway_Homo sapiens_hsa034602.78654841
6Mismatch repair_Homo sapiens_hsa034302.27079462
7Base excision repair_Homo sapiens_hsa034102.20127904
8Chemical carcinogenesis_Homo sapiens_hsa052041.94065625
9Butanoate metabolism_Homo sapiens_hsa006501.93003953
10Lysine degradation_Homo sapiens_hsa003101.90291155
11Steroid biosynthesis_Homo sapiens_hsa001001.87893633
12Folate biosynthesis_Homo sapiens_hsa007901.79001039
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74453416
14Glutathione metabolism_Homo sapiens_hsa004801.70032456
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69875996
16Nitrogen metabolism_Homo sapiens_hsa009101.68346004
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62983127
18Salivary secretion_Homo sapiens_hsa049701.57194516
19Olfactory transduction_Homo sapiens_hsa047401.50934190
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44340880
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43564757
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38546771
23Homologous recombination_Homo sapiens_hsa034401.37929431
24Fatty acid elongation_Homo sapiens_hsa000621.35242891
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34930884
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34529822
27Peroxisome_Homo sapiens_hsa041461.28978078
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28333039
29Non-homologous end-joining_Homo sapiens_hsa034501.27641532
30Protein export_Homo sapiens_hsa030601.20479260
31Cardiac muscle contraction_Homo sapiens_hsa042601.12209422
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11445277
33Linoleic acid metabolism_Homo sapiens_hsa005911.10880171
34Basal transcription factors_Homo sapiens_hsa030221.09834540
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09086478
36Nicotine addiction_Homo sapiens_hsa050331.07489367
37Oocyte meiosis_Homo sapiens_hsa041141.03833007
38Fat digestion and absorption_Homo sapiens_hsa049751.02859377
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02773370
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.01836505
41Morphine addiction_Homo sapiens_hsa050320.98869415
42Glycerolipid metabolism_Homo sapiens_hsa005610.97367833
43Regulation of autophagy_Homo sapiens_hsa041400.96381355
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94219594
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93712051
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93466197
47Arginine and proline metabolism_Homo sapiens_hsa003300.93449757
48RNA polymerase_Homo sapiens_hsa030200.90365350
49Insulin secretion_Homo sapiens_hsa049110.90273304
50Purine metabolism_Homo sapiens_hsa002300.87524258
51Parkinsons disease_Homo sapiens_hsa050120.85260880
52Hippo signaling pathway_Homo sapiens_hsa043900.82627380
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82074438
54Arachidonic acid metabolism_Homo sapiens_hsa005900.80789520
55Vitamin B6 metabolism_Homo sapiens_hsa007500.80438640
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.79439380
57mRNA surveillance pathway_Homo sapiens_hsa030150.79178528
58Pyruvate metabolism_Homo sapiens_hsa006200.79168048
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.76143630
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75886395
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75880853
62Basal cell carcinoma_Homo sapiens_hsa052170.73906417
63Retinol metabolism_Homo sapiens_hsa008300.73299393
64Nucleotide excision repair_Homo sapiens_hsa034200.72146351
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70844382
66Fatty acid degradation_Homo sapiens_hsa000710.70843606
67Caffeine metabolism_Homo sapiens_hsa002320.70089879
68Calcium signaling pathway_Homo sapiens_hsa040200.68092886
69TGF-beta signaling pathway_Homo sapiens_hsa043500.66582607
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65891126
71Dorso-ventral axis formation_Homo sapiens_hsa043200.64659992
72ABC transporters_Homo sapiens_hsa020100.64316747
73Dopaminergic synapse_Homo sapiens_hsa047280.64020632
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62262291
75beta-Alanine metabolism_Homo sapiens_hsa004100.61457890
76Cocaine addiction_Homo sapiens_hsa050300.61364396
77Sulfur relay system_Homo sapiens_hsa041220.59881923
78Arginine biosynthesis_Homo sapiens_hsa002200.59811041
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59521833
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59014229
81Axon guidance_Homo sapiens_hsa043600.57660879
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54654084
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54371124
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53797624
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52627847
86Pancreatic secretion_Homo sapiens_hsa049720.52163064
87Propanoate metabolism_Homo sapiens_hsa006400.50698410
88Tight junction_Homo sapiens_hsa045300.49870237
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.49525749
90Tyrosine metabolism_Homo sapiens_hsa003500.49370315
91Circadian entrainment_Homo sapiens_hsa047130.49048934
92Metabolic pathways_Homo sapiens_hsa011000.46981474
93Gastric acid secretion_Homo sapiens_hsa049710.45848307
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.43794199
95Oxidative phosphorylation_Homo sapiens_hsa001900.43568696
96cAMP signaling pathway_Homo sapiens_hsa040240.43168787
97GABAergic synapse_Homo sapiens_hsa047270.41834852
98Huntingtons disease_Homo sapiens_hsa050160.40287469
99Taste transduction_Homo sapiens_hsa047420.40075695
100MAPK signaling pathway_Homo sapiens_hsa040100.39436850

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »