HSFY1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein targeting to Golgi (GO:0000042)9.01827481
2chromosome condensation (GO:0030261)8.98422293
3DNA packaging (GO:0006323)8.67179400
4establishment of protein localization to Golgi (GO:0072600)8.66680719
5sperm capacitation (GO:0048240)8.52455542
6retrograde transport, vesicle recycling within Golgi (GO:0000301)8.43553927
7plasma membrane fusion (GO:0045026)8.30482618
8microtubule depolymerization (GO:0007019)8.24880625
9protein polyglutamylation (GO:0018095)7.93490084
10spermatid development (GO:0007286)7.64223554
11microtubule polymerization or depolymerization (GO:0031109)7.60935837
12rRNA methylation (GO:0031167)7.56384863
13centriole replication (GO:0007099)7.32419356
14single strand break repair (GO:0000012)7.18758064
15sperm-egg recognition (GO:0035036)6.96074872
16spermatid nucleus differentiation (GO:0007289)6.78560913
17response to pheromone (GO:0019236)6.67824811
18spermatogenesis (GO:0007283)6.54494616
19male gamete generation (GO:0048232)6.52325251
20multicellular organism reproduction (GO:0032504)6.50331744
21protein localization to Golgi apparatus (GO:0034067)6.49419949
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.47192492
23centriole assembly (GO:0098534)6.41085594
24rRNA modification (GO:0000154)6.38499884
25seminiferous tubule development (GO:0072520)6.26936910
26regulation of centriole replication (GO:0046599)6.26818927
27calcium ion-dependent exocytosis (GO:0017156)6.19442358
28binding of sperm to zona pellucida (GO:0007339)6.17235556
29reproduction (GO:0000003)6.02275302
30gamete generation (GO:0007276)6.00462512
31axonemal dynein complex assembly (GO:0070286)6.00338225
32phosphatidylethanolamine metabolic process (GO:0046337)5.97384790
33cell-cell recognition (GO:0009988)5.72109918
34microtubule severing (GO:0051013)5.69872409
35negative regulation of inclusion body assembly (GO:0090084)5.56029860
36sexual reproduction (GO:0019953)5.55264502
37RNA destabilization (GO:0050779)5.39795205
38single fertilization (GO:0007338)5.13304487
39regulation of cilium movement (GO:0003352)5.07724730
40cilium or flagellum-dependent cell motility (GO:0001539)5.06566413
41glomerular visceral epithelial cell development (GO:0072015)4.97513771
42motile cilium assembly (GO:0044458)4.93356128
43positive regulation of Rab GTPase activity (GO:0032851)4.90189038
44regulation of Rab GTPase activity (GO:0032313)4.90189038
45multicellular organismal reproductive process (GO:0048609)4.79978055
46microtubule nucleation (GO:0007020)4.73618184
47cell wall macromolecule catabolic process (GO:0016998)4.70527816
48glomerular epithelial cell development (GO:0072310)4.64526943
49fertilization (GO:0009566)4.60831305
50musculoskeletal movement (GO:0050881)4.58823209
51multicellular organismal movement (GO:0050879)4.58823209
52cell wall macromolecule metabolic process (GO:0044036)4.53779220
53epithelial cilium movement (GO:0003351)4.53658483
54nuclear pore complex assembly (GO:0051292)4.53210346
55germ cell development (GO:0007281)4.42542325
56nucleus organization (GO:0006997)4.33358119
57regulation of transcription involved in cell fate commitment (GO:0060850)4.32070003
58cellular process involved in reproduction in multicellular organism (GO:0022412)4.25605458
59cilium movement (GO:0003341)3.95481069
60regulation of inclusion body assembly (GO:0090083)3.94164369
61cellular ketone body metabolic process (GO:0046950)3.83632383
62glycerol ether metabolic process (GO:0006662)3.75520017
63chromatin silencing (GO:0006342)3.66564372
64membrane protein intracellular domain proteolysis (GO:0031293)3.59939977
65pore complex assembly (GO:0046931)3.51626214
66intra-Golgi vesicle-mediated transport (GO:0006891)3.50666900
67organic cation transport (GO:0015695)3.47891819
68regulation of microtubule-based movement (GO:0060632)3.47303218
69ether metabolic process (GO:0018904)3.46356142
70Golgi to endosome transport (GO:0006895)3.42388937
71nuclear pore organization (GO:0006999)3.40371515
72ketone body metabolic process (GO:1902224)3.37407541
73RNA localization (GO:0006403)3.21102179
74negative regulation of Rho protein signal transduction (GO:0035024)3.19909547
75ventricular system development (GO:0021591)3.18945923
76protein depolymerization (GO:0051261)3.13829193
77multicellular organismal development (GO:0007275)3.04927641
78regulation of interleukin-13 production (GO:0032656)3.04632749
79homeostasis of number of cells within a tissue (GO:0048873)3.03473720
80polyamine biosynthetic process (GO:0006596)3.03235128
81axoneme assembly (GO:0035082)3.02926382
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.98246633
83cellular response to pH (GO:0071467)2.98196344
84centrosome duplication (GO:0051298)2.94262654
85positive regulation of guanylate cyclase activity (GO:0031284)2.94116629
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93590573
87vesicle transport along microtubule (GO:0047496)2.93003743
88mitotic G1 DNA damage checkpoint (GO:0031571)2.89916922
89cerebral cortex neuron differentiation (GO:0021895)2.89084376
90histone H3-K9 demethylation (GO:0033169)2.88719661
91regulation of somitogenesis (GO:0014807)2.87146731
92receptor recycling (GO:0001881)2.85578013
93response to acidic pH (GO:0010447)2.84797188
94coenzyme catabolic process (GO:0009109)2.80125190
95RNA methylation (GO:0001510)2.78507746
96DNA conformation change (GO:0071103)2.78295120
97regulation of phosphoprotein phosphatase activity (GO:0043666)2.77841346
98sperm motility (GO:0030317)12.0307508
99fusion of sperm to egg plasma membrane (GO:0007342)10.9616566
100acrosome reaction (GO:0007340)10.7814574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.47691528
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02280765
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.43199105
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07420226
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52174089
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.52174089
7EZH2_22144423_ChIP-Seq_EOC_Human2.44367109
8FUS_26573619_Chip-Seq_HEK293_Human2.31963000
9CBP_20019798_ChIP-Seq_JUKART_Human2.31858711
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.31858711
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20177442
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15859153
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12290663
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.04624045
15DROSHA_22980978_ChIP-Seq_HELA_Human1.88043037
16RAC3_21632823_ChIP-Seq_H3396_Human1.86097528
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.73712005
18ERA_21632823_ChIP-Seq_H3396_Human1.72316935
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68975289
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68154794
21EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.66481221
22MYC_19829295_ChIP-Seq_ESCs_Human1.63128352
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.61821772
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61757270
25NANOG_20526341_ChIP-Seq_ESCs_Human1.61119460
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.60855419
27ER_23166858_ChIP-Seq_MCF-7_Human1.60266332
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.57839574
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.57676175
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.57170444
31TAF2_19829295_ChIP-Seq_ESCs_Human1.56159417
32CBX2_22325352_ChIP-Seq_293T-Rex_Human1.54650076
33RBPJ_21746931_ChIP-Seq_IB4_Human1.52290211
34HNFA_21074721_ChIP-Seq_CACO-2_Human1.52277865
35CTCF_27219007_Chip-Seq_Bcells_Human1.50899899
36PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47763285
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47718314
38CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.46204757
39ETV1_20927104_ChIP-Seq_GIST48_Human1.44311022
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.40931598
41BCL6_27268052_Chip-Seq_Bcells_Human1.40665063
42ERG_20517297_ChIP-Seq_VCAP_Human1.38903912
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.38643639
44SMC4_20622854_ChIP-Seq_HELA_Human1.38444397
45NFYB_21822215_ChIP-Seq_K562_Human1.37229734
46TP53_18474530_ChIP-ChIP_U2OS_Human1.36354040
47AR_25329375_ChIP-Seq_VCAP_Human1.34567123
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33387770
49P300_19829295_ChIP-Seq_ESCs_Human1.33375068
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32966358
51OCT4_20526341_ChIP-Seq_ESCs_Human1.32942077
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32882787
53TBL1_22424771_ChIP-Seq_293T_Human1.32224146
54CTCF_20526341_ChIP-Seq_ESCs_Human1.31517316
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31293293
56TP63_22573176_ChIP-Seq_HFKS_Human1.30030605
57PHF8_20622853_ChIP-Seq_HELA_Human1.28839737
58CEBPB_22108803_ChIP-Seq_LS180_Human1.28760393
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.28175097
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.27717833
61BCOR_27268052_Chip-Seq_Bcells_Human1.27583120
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26584922
63P68_20966046_ChIP-Seq_HELA_Human1.25539272
64PHF8_20622854_ChIP-Seq_HELA_Human1.25039110
65E2F1_20622854_ChIP-Seq_HELA_Human1.23827515
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.23597421
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.23576460
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23078371
69SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22433369
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22204267
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21602841
72PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18916477
73ZNF274_21170338_ChIP-Seq_K562_Hela1.18675109
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18477258
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17430975
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15328100
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.14542939
78STAT3_23295773_ChIP-Seq_U87_Human1.13943057
79NFYA_21822215_ChIP-Seq_K562_Human1.12999238
80P300_27268052_Chip-Seq_Bcells_Human1.12942072
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11471554
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10815435
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10157054
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07772365
85SMAD4_21799915_ChIP-Seq_A2780_Human1.07572253
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06910195
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.06612531
88RUNX2_22187159_ChIP-Seq_PCA_Human1.06597057
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06210747
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05710541
91P53_21459846_ChIP-Seq_SAOS-2_Human1.05626276
92SA1_27219007_Chip-Seq_Bcells_Human1.03777386
93LXR_22292898_ChIP-Seq_THP-1_Human1.03054712
94TAF15_26573619_Chip-Seq_HEK293_Human1.02014359
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01984766
96RUNX_20019798_ChIP-Seq_JUKART_Human1.01713092
97KLF5_25053715_ChIP-Seq_YYC3_Human1.01688799
98NANOG_19829295_ChIP-Seq_ESCs_Human1.00699329
99SOX2_19829295_ChIP-Seq_ESCs_Human1.00699329
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00457429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology6.16328931
2MP0005377_hearing/vestibular/ear_phenot6.16328931
3MP0005670_abnormal_white_adipose4.87423365
4MP0003698_abnormal_male_reproductive4.27394579
5MP0001929_abnormal_gametogenesis3.77828241
6MP0001348_abnormal_lacrimal_gland3.32865590
7MP0005451_abnormal_body_composition2.38978926
8MP0002161_abnormal_fertility/fecundity2.38053882
9MP0003646_muscle_fatigue2.27980979
10MP0003718_maternal_effect2.24303670
11MP0001485_abnormal_pinna_reflex2.07772864
12MP0005410_abnormal_fertilization11.5863073
13MP0005310_abnormal_salivary_gland1.91214999
14MP0000678_abnormal_parathyroid_gland1.89932322
15MP0005379_endocrine/exocrine_gland_phen1.80175606
16MP0001486_abnormal_startle_reflex1.74819806
17MP0002210_abnormal_sex_determination1.74144403
18MP0003879_abnormal_hair_cell1.71212503
19MP0005423_abnormal_somatic_nervous1.65923116
20MP0003011_delayed_dark_adaptation1.57447271
21MP0002132_abnormal_respiratory_system1.56827916
22MP0004742_abnormal_vestibular_system1.49898195
23MP0001145_abnormal_male_reproductive1.42411614
24MP0000653_abnormal_sex_gland1.33744061
25MP0002282_abnormal_trachea_morphology1.31300203
26MP0004859_abnormal_synaptic_plasticity1.26195219
27MP0001963_abnormal_hearing_physiology1.23031546
28MP0002234_abnormal_pharynx_morphology1.21526321
29MP0001765_abnormal_ion_homeostasis1.13165196
30MP0009115_abnormal_fat_cell1.12301271
31MP0009053_abnormal_anal_canal1.11320615
32MP0002249_abnormal_larynx_morphology1.06133448
33MP0002138_abnormal_hepatobiliary_system1.05913191
34MP0004510_myositis1.04305327
35MP0002822_catalepsy0.99460276
36MP0005551_abnormal_eye_electrophysiolog0.98488197
37MP0000026_abnormal_inner_ear0.98390742
38MP0005395_other_phenotype0.96994204
39MP0000534_abnormal_ureter_morphology0.96611572
40MP0005666_abnormal_adipose_tissue0.94438920
41MP0002127_abnormal_cardiovascular_syste0.91827279
42MP0005253_abnormal_eye_physiology0.89614769
43MP0009697_abnormal_copulation0.89552582
44MP0002735_abnormal_chemical_nociception0.88538475
45MP0002229_neurodegeneration0.86467040
46MP0001984_abnormal_olfaction0.85812124
47MP0001968_abnormal_touch/_nociception0.85119512
48MP0008877_abnormal_DNA_methylation0.84886872
49MP0000955_abnormal_spinal_cord0.82991020
50MP0005167_abnormal_blood-brain_barrier0.79572419
51MP0005248_abnormal_Harderian_gland0.79463790
52MP0002067_abnormal_sensory_capabilities0.76534086
53MP0005083_abnormal_biliary_tract0.70120407
54MP0005375_adipose_tissue_phenotype0.68585759
55MP0008569_lethality_at_weaning0.66837697
56MP0004233_abnormal_muscle_weight0.66562331
57MP0002557_abnormal_social/conspecific_i0.65361996
58MP0004085_abnormal_heartbeat0.64531274
59MP0008995_early_reproductive_senescence0.63540175
60MP0005397_hematopoietic_system_phenotyp0.61099900
61MP0001545_abnormal_hematopoietic_system0.61099900
62MP0001905_abnormal_dopamine_level0.60551193
63MP0005636_abnormal_mineral_homeostasis0.60466951
64MP0000230_abnormal_systemic_arterial0.60183550
65MP0002572_abnormal_emotion/affect_behav0.57991124
66MP0003077_abnormal_cell_cycle0.57297236
67MP0002733_abnormal_thermal_nociception0.56234963
68MP0001666_abnormal_nutrient_absorption0.56016875
69MP0010329_abnormal_lipoprotein_level0.54022555
70MP0004484_altered_response_of0.53136722
71MP0004036_abnormal_muscle_relaxation0.51502096
72MP0001440_abnormal_grooming_behavior0.51051708
73MP0003137_abnormal_impulse_conducting0.50888066
74MP0000681_abnormal_thyroid_gland0.50609591
75MP0004084_abnormal_cardiac_muscle0.49041381
76MP0005332_abnormal_amino_acid0.48674341
77MP0000003_abnormal_adipose_tissue0.48437621
78MP0005535_abnormal_body_temperature0.47560472
79MP0005645_abnormal_hypothalamus_physiol0.46816338
80MP0005084_abnormal_gallbladder_morpholo0.46496378
81MP0005367_renal/urinary_system_phenotyp0.45026839
82MP0000516_abnormal_urinary_system0.45026839
83MP0000049_abnormal_middle_ear0.44986144
84MP0002272_abnormal_nervous_system0.44742303
85MP0005408_hypopigmentation0.43995722
86MP0009745_abnormal_behavioral_response0.41451994
87MP0002928_abnormal_bile_duct0.41094729
88MP0009764_decreased_sensitivity_to0.40480887
89MP0001501_abnormal_sleep_pattern0.40161346
90MP0005391_vision/eye_phenotype0.39821985
91MP0008961_abnormal_basal_metabolism0.38793117
92MP0001879_abnormal_lymphatic_vessel0.38560543
93MP0000249_abnormal_blood_vessel0.38057080
94MP0003631_nervous_system_phenotype0.37323992
95MP0002734_abnormal_mechanical_nocicepti0.37285070
96MP0005595_abnormal_vascular_smooth0.36574586
97MP0002653_abnormal_ependyma_morphology0.35869986
98MP0001970_abnormal_pain_threshold0.35866373
99MP0004782_abnormal_surfactant_physiolog0.34914589
100MP0004957_abnormal_blastocyst_morpholog0.34906419

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.21781903
2Tubulointerstitial nephritis (HP:0001970)6.86213854
3Chronic hepatic failure (HP:0100626)6.61205772
4Asymmetric septal hypertrophy (HP:0001670)6.29434528
5Absent/shortened dynein arms (HP:0200106)6.07552210
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.07552210
7Cone-rod dystrophy (HP:0000548)4.85441155
8Male infertility (HP:0003251)4.78626178
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.59074540
10Hyperkalemia (HP:0002153)4.53359041
11Resting tremor (HP:0002322)4.50730385
12Abnormal ciliary motility (HP:0012262)4.43943039
13Abnormal respiratory motile cilium physiology (HP:0012261)4.43789289
14Abnormality of macular pigmentation (HP:0008002)4.41141514
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.35395995
16Attenuation of retinal blood vessels (HP:0007843)4.26695050
17Nasal polyposis (HP:0100582)4.24885592
18Bony spicule pigmentary retinopathy (HP:0007737)4.17862170
19Hypoalphalipoproteinemia (HP:0003233)4.15320565
20Abnormal respiratory epithelium morphology (HP:0012253)4.05545799
21Abnormal respiratory motile cilium morphology (HP:0005938)4.05545799
22Menstrual irregularities (HP:0000858)3.96757054
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.94288919
24Infertility (HP:0000789)3.91395781
25Progressive sensorineural hearing impairment (HP:0000408)3.89372071
26Amelogenesis imperfecta (HP:0000705)3.86995233
27Hypoplasia of the thymus (HP:0000778)3.77273035
28Impulsivity (HP:0100710)3.61192698
29Renovascular hypertension (HP:0100817)3.51366258
30Abnormality of the nasal mucosa (HP:0000433)3.47392006
31Abnormality of dental color (HP:0011073)3.45965836
32Facial shape deformation (HP:0011334)3.32478153
33Potter facies (HP:0002009)3.32478153
34Bell-shaped thorax (HP:0001591)3.28936621
35Insulin-resistant diabetes mellitus (HP:0000831)3.26843054
36Portal hypertension (HP:0001409)3.24513129
37Truncal obesity (HP:0001956)3.22187298
38Stage 5 chronic kidney disease (HP:0003774)3.14741980
39Progressive cerebellar ataxia (HP:0002073)3.14317126
40Tubulointerstitial abnormality (HP:0001969)3.13702608
41Postural instability (HP:0002172)3.10625641
42Abnormality of the hepatic vasculature (HP:0006707)2.98386037
43Enlarged epiphyses (HP:0010580)2.92595367
44Nephronophthisis (HP:0000090)2.90446333
45Abnormal rod and cone electroretinograms (HP:0008323)2.84760203
46Abnormal spermatogenesis (HP:0008669)2.76969085
47Hypoplastic ischia (HP:0003175)2.71953996
48Increased purine levels (HP:0004368)2.64896861
49Hyperuricemia (HP:0002149)2.64896861
50Abnormality of the costochondral junction (HP:0000919)2.63592697
51Rhinitis (HP:0012384)2.63244403
52Subcapsular cataract (HP:0000523)2.60540479
53Intellectual disability, moderate (HP:0002342)2.57208407
54Progressive hearing impairment (HP:0001730)2.56567832
55Abnormal urine output (HP:0012590)2.53016222
56Ventricular tachycardia (HP:0004756)2.51438352
57Focal segmental glomerulosclerosis (HP:0000097)2.46761766
58Abnormality of the ischium (HP:0003174)2.46551488
59Abnormality of the renal medulla (HP:0100957)2.46380751
60Abnormality of potassium homeostasis (HP:0011042)2.45085837
61Abnormal drinking behavior (HP:0030082)2.41676298
62Polydipsia (HP:0001959)2.41676298
63Generalized aminoaciduria (HP:0002909)2.40791891
64Chronic bronchitis (HP:0004469)2.30552138
65Azoospermia (HP:0000027)2.20930808
66Abnormality of renal excretion (HP:0011036)2.18868759
67Osteomalacia (HP:0002749)2.17985261
68Unilateral renal agenesis (HP:0000122)2.17712339
69Abnormality of the aortic arch (HP:0012303)2.16862253
70Myokymia (HP:0002411)2.11191092
71Hypolipoproteinemia (HP:0010981)2.09943622
72Hypophosphatemic rickets (HP:0004912)2.09403453
73Bradycardia (HP:0001662)2.06949426
74Polyuria (HP:0000103)2.04823822
75Recurrent pneumonia (HP:0006532)2.04282963
76Glomerulosclerosis (HP:0000096)2.02928825
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02700474
78Renal Fanconi syndrome (HP:0001994)1.93863853
79Sandal gap (HP:0001852)1.93471040
80Insulin resistance (HP:0000855)1.92449184
81Double outlet right ventricle (HP:0001719)1.92356666
82Congenital malformation of the right heart (HP:0011723)1.92356666
83Flattened epiphyses (HP:0003071)1.89069772
84Renal dysplasia (HP:0000110)1.88574922
85Bronchiectasis (HP:0002110)1.87697612
86Abnormal albumin level (HP:0012116)1.87495547
87Hypoalbuminemia (HP:0003073)1.87495547
88Hyponatremia (HP:0002902)1.86505807
89Recurrent corneal erosions (HP:0000495)1.86360684
90Decreased central vision (HP:0007663)1.85466710
91Tubular atrophy (HP:0000092)1.84755767
92Abnormality of purine metabolism (HP:0004352)1.83732539
93Widely patent fontanelles and sutures (HP:0004492)1.83304197
94Horizontal nystagmus (HP:0000666)1.75448660
95Optic nerve hypoplasia (HP:0000609)1.73466110
96Convex nasal ridge (HP:0000444)1.71090967
97Abnormality of the parathyroid morphology (HP:0011766)1.70064538
98Abnormality of the epiphysis of the femoral head (HP:0010574)1.69586416
99Photophobia (HP:0000613)1.69032816
100Gingivitis (HP:0000230)1.68464975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.65961167
2TESK14.57385932
3BRD44.36231248
4PLK23.75815883
5MAP4K23.49186669
6PNCK3.32251014
7DDR23.27193817
8CAMK1G2.56613061
9PIK3CG2.50980098
10STK382.30186273
11PRKD32.10221379
12PLK410.0017139
13STK38L1.90360221
14MAPK151.86438290
15TYRO31.78259769
16PDK11.52411830
17CDK121.51728828
18NEK61.49524388
19PDPK11.48628911
20MST1R1.33300257
21WNK11.27745110
22PTK2B1.18876174
23DYRK1B1.18740773
24AKT30.96728568
25CDK70.96553570
26CAMK1D0.95155504
27PRKG20.82972866
28TIE10.81025157
29MAP3K110.75405650
30KSR20.70327152
31SIK20.69366330
32BRAF0.59298295
33WNK40.58347132
34CAMK10.55022547
35PRKG10.55018904
36MAP3K90.52524136
37MARK10.50040299
38MAP2K20.49729165
39RPS6KA20.49322082
40SGK4940.46738778
41SGK2230.46738778
42PRKAA20.45935776
43LATS20.45671492
44CDK30.43923012
45RPS6KA10.43738831
46STK390.43048942
47MAP3K20.40187840
48CDK20.39830142
49BRSK10.39091519
50MAPK10.38280722
51CDK10.37295032
52NTRK30.36659826
53GSK3B0.36497125
54ROCK10.35110073
55UHMK10.34398192
56JAK30.33295985
57LATS10.29433138
58PRKCG0.28753265
59CAMK40.28487797
60MAP3K80.27907994
61MAPK80.27264672
62MAP3K10.27200895
63SGK10.26582253
64BMPR1B0.26267111
65MTOR0.25257980
66PRKCZ0.24516681
67SGK20.23613690
68MAP3K40.23310431
69RPS6KC10.22430011
70RPS6KL10.22430011
71MUSK0.22319546
72CHEK10.22031982
73CDK40.21499032
74PRKCB0.20235321
75BRSK20.19801495
76MAPK140.19482868
77RPS6KA60.19237503
78TNIK0.19150210
79TESK20.17376143
80MARK20.16309498
81BLK0.15753641
82MAPK100.15478100
83DYRK30.14728130
84OXSR10.13527230
85AKT10.11890051
86MAPK110.10430177
87PRKACB0.09975658
88MET0.09689498
89SGK30.09544223
90PKN10.09218778
91NEK20.07272981
92ZAK0.06961849
93ARAF0.06878196
94PRKACA0.06860226
95MAPK90.05295469
96RIPK40.04435339
97MAP3K70.03574755
98CSNK1A10.03387321
99CAMK2A0.02630368
100PRKAA10.02377349

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000617.56920752
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.69723842
3Olfactory transduction_Homo sapiens_hsa047404.04761988
4RNA transport_Homo sapiens_hsa030132.23052259
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.17739344
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16358126
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12562826
8Butanoate metabolism_Homo sapiens_hsa006501.94408754
9Fatty acid degradation_Homo sapiens_hsa000711.90519310
10Taste transduction_Homo sapiens_hsa047421.88383207
11Dorso-ventral axis formation_Homo sapiens_hsa043201.85893554
12Fatty acid metabolism_Homo sapiens_hsa012121.71960536
13Phenylalanine metabolism_Homo sapiens_hsa003601.67931632
14Type II diabetes mellitus_Homo sapiens_hsa049301.57831664
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55255645
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.38125779
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32412205
18Type I diabetes mellitus_Homo sapiens_hsa049401.22527229
19Phototransduction_Homo sapiens_hsa047441.19971759
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.15536480
21Salivary secretion_Homo sapiens_hsa049701.15051131
22Protein digestion and absorption_Homo sapiens_hsa049741.14812168
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13852358
24Synaptic vesicle cycle_Homo sapiens_hsa047211.13160012
25Antigen processing and presentation_Homo sapiens_hsa046121.13053211
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10853553
27PPAR signaling pathway_Homo sapiens_hsa033201.07062997
28Autoimmune thyroid disease_Homo sapiens_hsa053201.05111389
29Inositol phosphate metabolism_Homo sapiens_hsa005621.04746650
30Allograft rejection_Homo sapiens_hsa053301.04700770
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98865697
32Arginine biosynthesis_Homo sapiens_hsa002200.98332866
33ABC transporters_Homo sapiens_hsa020100.96605798
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95357880
35Morphine addiction_Homo sapiens_hsa050320.95097117
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94432812
37Calcium signaling pathway_Homo sapiens_hsa040200.94397378
38Endocytosis_Homo sapiens_hsa041440.93608218
39Graft-versus-host disease_Homo sapiens_hsa053320.90694089
40Nicotine addiction_Homo sapiens_hsa050330.90342682
41Glutamatergic synapse_Homo sapiens_hsa047240.89023416
42Cardiac muscle contraction_Homo sapiens_hsa042600.88513485
43cAMP signaling pathway_Homo sapiens_hsa040240.88406351
44Arginine and proline metabolism_Homo sapiens_hsa003300.85617565
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84316610
46Viral myocarditis_Homo sapiens_hsa054160.84298544
47Glycerolipid metabolism_Homo sapiens_hsa005610.82947191
48Influenza A_Homo sapiens_hsa051640.82607302
49Fat digestion and absorption_Homo sapiens_hsa049750.82082522
50Oocyte meiosis_Homo sapiens_hsa041140.77277551
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76678011
52Circadian entrainment_Homo sapiens_hsa047130.76375210
53Renin secretion_Homo sapiens_hsa049240.73848611
54VEGF signaling pathway_Homo sapiens_hsa043700.71637862
55Tyrosine metabolism_Homo sapiens_hsa003500.71110583
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68257622
57Renin-angiotensin system_Homo sapiens_hsa046140.66962449
58Pancreatic secretion_Homo sapiens_hsa049720.65466856
59Serotonergic synapse_Homo sapiens_hsa047260.62815844
60Hedgehog signaling pathway_Homo sapiens_hsa043400.61345734
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59888167
62Nitrogen metabolism_Homo sapiens_hsa009100.59058743
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58883081
64Bile secretion_Homo sapiens_hsa049760.57163016
65Gastric acid secretion_Homo sapiens_hsa049710.55372424
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.54955192
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54456566
68Retinol metabolism_Homo sapiens_hsa008300.53905005
69Long-term potentiation_Homo sapiens_hsa047200.53689685
70Estrogen signaling pathway_Homo sapiens_hsa049150.52347665
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51404005
72Acute myeloid leukemia_Homo sapiens_hsa052210.49240501
73Fanconi anemia pathway_Homo sapiens_hsa034600.47000891
74Insulin secretion_Homo sapiens_hsa049110.46641964
75MAPK signaling pathway_Homo sapiens_hsa040100.43764267
76Biosynthesis of amino acids_Homo sapiens_hsa012300.43651778
77mRNA surveillance pathway_Homo sapiens_hsa030150.42224588
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.39972373
79Purine metabolism_Homo sapiens_hsa002300.39720293
80Cholinergic synapse_Homo sapiens_hsa047250.38959518
81ECM-receptor interaction_Homo sapiens_hsa045120.38504568
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38164793
83GABAergic synapse_Homo sapiens_hsa047270.38019709
84Amphetamine addiction_Homo sapiens_hsa050310.36995798
85Tight junction_Homo sapiens_hsa045300.32592192
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31075674
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30915852
88Huntingtons disease_Homo sapiens_hsa050160.30345074
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.29183049
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28756867
91Oxytocin signaling pathway_Homo sapiens_hsa049210.28671924
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26539623
93Vitamin B6 metabolism_Homo sapiens_hsa007500.26384121
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23609449
95Selenocompound metabolism_Homo sapiens_hsa004500.23194085
96Prolactin signaling pathway_Homo sapiens_hsa049170.21767101
97Sulfur relay system_Homo sapiens_hsa041220.20114007
98Herpes simplex infection_Homo sapiens_hsa051680.15285277
99Base excision repair_Homo sapiens_hsa034100.13561465
100Carbon metabolism_Homo sapiens_hsa012000.13216681

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